{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66245", "l": "ATP + H(+) + IC-asc-C9 => diphosphate + IC-asc-C9-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646468", "l": "mTORC1 binds RHEB:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392831", "l": "Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917841", "l": "Acidification of Tf:TfR1 containing endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21842", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47910", "l": "6-deoxy-6-sulfo-D-gluconate + H(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67531", "l": "(6Z)-octenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62325", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36845", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73180", "l": "S-adenosyl-L-methionine + scutellarein => H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29800", "l": "ATP + D-allose(out) + H2O => ADP + D-allose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15657", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.68", "l": "\"1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20743", "l": "H2O + trans-2,3-epoxysuccinate <=> (2R,3S)-tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103082", "l": "2-(4'-methylthio)butylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O = H+ + 2-(4'-methylthio)butylmalate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68937", "l": "ATP + H(+) + NADPH + nonanoate => AMP + diphosphate + NADP(+) + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14848", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53330", "l": "2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2,3-diacyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66000", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.378", "l": "\"[methyl-Co(III) glycine betaine-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9749197", "l": "ORC1 binds to H4K20me2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008823", "l": "cupric reductase activity", "d": ["Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130151", "l": "Dimerization of DAP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55730", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789208", "l": "HOCl-induced glycosaminoglycan fragmentation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627072", "l": "RHOQ binds GOPC:CFTR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59822", "l": "adenosine 3'-diphosphate,5'-triphosphate + AMP => 2 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37922", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59369", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000327", "l": "PLK1 phosphorylates BORA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611721", "l": "β1-agonists bind ADRB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989751", "l": "Expression of FABP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74219", "l": "H2O + L-seryl-tRNA(Thr) = L-serine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56105", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 => 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13569", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.165", "l": "\"N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47799", "l": "an aralkylamine + H2O + 2 oxidized [azurin] <=> an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684352", "l": "nsp3-4 cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.65", "l": "\"peptidase 1 (mite)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68201", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA => 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46943", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] <=> ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430190", "l": "p-SLP-76 binds NCK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49019", "l": "aurachin C epoxide <=> 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73577", "l": "CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15368", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005212", "l": "structural constituent of eye lens", "d": ["The action of a molecule that contributes to the structural integrity of the lens of an eye."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69927", "l": "adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71302", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) <=> chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50106", "l": "CoA + H(+) + N-tetradecanoyl-taurine => taurine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.726079367374183", "identifiers": [{"i": "GO:0098960", "l": "postsynaptic neurotransmitter receptor activity", "d": ["Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.921857375477728", "identifiers": [{"i": "GO:0004521", "l": "RNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17578", "l": "ADP-D-glycero-beta-D-manno-heptose => ADP-L-glycero-beta-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669870", "l": "Regorafenib-resistant KIT mutants do not bind regorafenib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024785", "l": "RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44258", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77271", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112434", "l": "Formation of DSIF complex  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624131", "l": "UNC119B binds myristoylated proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428273", "l": "SPHK1 phosphorylates sphingoid (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388503", "l": "Oxytocin receptor bind oxytocin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0017153", "l": "sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73560", "l": "dGTP(out) + UTP(in) => dGTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54015", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65153", "l": "(2S)-naringenin + UDP-alpha-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49315", "l": "2-trans,4-trans-xanthoxin + NAD(+) <=> 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008427", "l": "calcium-dependent protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19338", "l": "2 hydroxylamine + 2 NAD(+) => 2 H(+) + hyponitrous acid + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52381", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674019", "l": "BRAP binds KSR1:MARK3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29036", "l": "ATP + H2O + L-glutamate(out) => ADP + H(+) + L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14073", "l": "3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.16", "l": "\"hydroxyglutamate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168445", "l": "PTP1B binds the GH receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018764", "l": "N-isopropylammelide isopropylaminohydrolase activity", "d": ["Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700154", "l": "Active ALK binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51192", "l": "(R)-2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682718", "l": "nsp15 forms a hexamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994148", "l": "LRRC16A binds F-actin capping protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33575", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose = a mannosylinositol-1-phosphophytoceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688838", "l": "RIPK3 binds STUB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.7", "l": "\"aldehyde dehydrogenase (FAD-independent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64817", "l": "5-aminolevulinate(in) => 5-aminolevulinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40295", "l": "ATP + CoA + hexadecanedioate = AMP + diphosphate + hexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001066", "l": "plastid single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705323", "l": "Phosphorylation of TBK1/IKBKE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963864", "l": "CUBN dissociates from 25(OH)D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696183", "l": "AOC3 deaminates BZAM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853317", "l": "FGFR3 fusions dimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66123", "l": "2-oxobutanoate + L-methionine <=> (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64325", "l": "(11Z)-octadecenoyl-CoA + cholesterol => cholesteryl (11Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18037", "l": "agmatine + H2O = N-carbamoylputrescine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.12", "l": "\"agmatine deiminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639286", "l": "RRAGC,D exchanges GTP for GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811427", "l": "COPI vesicle uncoating at the ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65901", "l": "3-hydroxy-L-kynurenine + glyoxylate => glycine + H2O + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102461", "l": "kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose = kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026901", "l": "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034784", "l": "pivalyl-CoA mutase activity", "d": ["Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964475", "l": "DREAM complex binds the TOP2A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0005507", "l": "copper ion binding", "d": ["Binding to a copper (Cu) ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037612", "l": "H antigen-sec translocates from Golgi lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14995", "l": "a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420365", "l": "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202703", "l": "CD47 binds SIRP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098623", "l": "selenite reductase activity", "d": ["Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O."], "t": []}, {"i": "REACT:R-HSA-2408558", "l": "SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41839", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205286", "l": "GRB2:SOS interacts with p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755572", "l": "Defective SRD5A3 does not reduce pPNOL to DCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36617", "l": "CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine => 2-hydroxyoctadecanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656244", "l": "DRD2 binds DA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033420", "l": "CUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39686", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64642", "l": "lactose + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615249", "l": "ARBs bind AGRT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68480", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) = CO2 + H2O + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32244", "l": "alpha-D-ribose 1,5-bisphosphate => D-ribulose 1,5-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840401", "l": "DELE1(143-515) is released into the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340226", "l": "CYGB dioxygenates NO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15271", "l": "H(+) + L-ascorbate => L-xylo-hex-3-ulonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37473", "l": "CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine => 3-methylbutanoyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592278", "l": "Autocatalytic activation of proMMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70702", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160931", "l": "Disassembly of tight junctions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26321", "l": "resorcinol + S-adenosyl-L-methionine = 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.n1", "l": "\"resorcinol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61231", "l": "H2O + L-histidine + O2 <=> 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376149", "l": "Proteolytic processing of SLIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14065", "l": "scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.44", "l": "\"myo-inosose-2 dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694583", "l": "ABHD4 hydrolyses NAPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805730", "l": "SETD9 methylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54915", "l": "11-cis-retinol + NADP(+) <=> 11-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021357", "l": "PRKCI phosphorylates ELF3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086038", "l": "calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52486", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.51", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.60", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417908", "l": "P2RY1 binds ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204500", "l": "CyP60 chaperones Basigin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18501", "l": "ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.71", "l": "\"Delta(24(24(1)))-sterol reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68917", "l": "ATP + butanoate + H(+) + NADPH => AMP + butanal + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71044", "l": "L-alanine(in) + L-phenylalanine(out) => L-alanine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59672", "l": "D-maltotriose + O2 = D-maltotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11862", "l": "ADP + H(+) + N(tele)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32550", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-sabinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "55.20033635754347", "identifiers": [{"i": "GO:0016788", "l": "hydrolase activity, acting on ester bonds", "d": ["Catalysis of the hydrolysis of any ester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.87", "l": "\"aralkylamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39559", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA = (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20465", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48055", "l": "n 3'-phosphoadenylyl sulfate + dermatan <=> n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26480", "l": "a 2-demethylmenaquinol + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54734", "l": "H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44620", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17993", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine = ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.23", "l": "\"homoglutathione synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034582", "l": "3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate <=> alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198314", "l": "DAG stimulates protein kinase C-delta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68211", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45643", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74375", "l": "H2O2(out) = H2O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14194", "l": "3-hydroxybenzoate + AH2 + O2 => 2,3-dihydroxybenzoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73791", "l": "dimethylallyl diphosphate + neoechinulin A = diphosphate + variecolorin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40532", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674385", "l": "p-T,Y MAPKs dimerize (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21520", "l": "2 Fe(III)-[cytochrome b1] + formate = CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": [], "t": []}, {"i": "EC:1.2.2.1", "l": "\"formate dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534359", "l": "CatSper Channel Mediated Calcium Transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49783", "l": "docosanoyl-CoA + glycine <=> CoA + H(+) + N-docosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38715", "l": "ATP + choline(out) + H2O = ADP + choline(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842656", "l": "ALK binds ALKAL ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68764", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32931", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol = a cardiolipin + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.41", "l": "\"cardiolipin synthase (CMP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35117", "l": "(4-coumaroyl)acetyl-CoA + CO2 + CoA => 4-coumaroyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166215", "l": "FA spontaneously flip-flops back to the matrix side (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27700", "l": "beta-L-galactose 1-phosphate + GDP + H(+) => GDP-beta-L-galactose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070041", "l": "rRNA (uridine-C5-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106158", "l": "glycero-3-phosphocholine acyltransferase activity", "d": ["Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine."], "t": []}, {"i": "RHEA:58476", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18991", "l": "2-methylpropan-1-amine + CO2 => H(+) + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202164", "l": "Translocation of PDK1 to Plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373087", "l": "Receptor CCR6 binds CCL20 ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047570", "l": "3-oxoadipate enol-lactonase activity", "d": ["Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21030", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] => acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32734", "l": "a diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250930", "l": "B-WICH recruits histone acetyltransferases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74915", "l": "a (2E)-enoyl fatty acid + ATP + H(+) = a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047357", "l": "UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H+ + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.72", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696958", "l": "USP44 deubiquitinates CDC20 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63899", "l": "aspulvinone E + hnu <=> isoaspulvinone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68151", "l": "2-octanone + H(+) + NADPH <=> (2R)-octan-2-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879674", "l": "CD97 binds CD55 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11554", "l": "1-O-alkyl-sn-glycerol + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71471", "l": "H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047347", "l": "aldose-1-phosphate nucleotidyltransferase activity", "d": ["Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38238", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol <=> 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60192", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11962", "l": "(S)-2-succinylamino-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50456", "l": "prostaglandin H3 = prostaglandin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24415", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) <=> 4-formylbenzenesulfonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36223", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420661", "l": "Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63348", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] = (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57540", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57118", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41787", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) <=> CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804402", "l": "TP53 binds POU4F1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619838", "l": "ARC binds DNM2 and SH3GL3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9660192", "l": "VDR agonists bind VDR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22201", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14672", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611721", "l": "β1-agonists bind ADRB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202709", "l": "JAM2 dimerises (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951676", "l": "RUNX3 binds TEADs and YAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61835", "l": "sitosterol + UDP-alpha-D-glucose <=> H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39604", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730886", "l": "Phosphorylation of SHC by SYK kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19010", "l": "a 3-acylpyruvate + H2O => a carboxylate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454928", "l": "ABCG4 may mediate cholesterol efflux (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15676", "l": "acetoacetyl-CoA + H2O <=> acetoacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29658", "l": "L-cysteine(in) <=> L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140978", "l": "mitochondrial large ribosomal subunit binding", "d": ["Binding to a mitochondrial large ribosomal subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51263", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592246", "l": "Expression of TFAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28120", "l": "D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP => di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25245", "l": "(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28349", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 7,8-dihydromonapterin 3'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74376", "l": "H2O2(out) => H2O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48122", "l": "a ganglioside GM3 + N-acetylneuraminate => a ganglioside GD3 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18700", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) <=> (4-hydroxyphenyl)acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23715", "l": "NADP(+) + pregnan-21-ol <=> H(+) + NADPH + pregnan-21-al", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36391", "l": "cholesterol + NADP(+) = desmosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688786", "l": "ATXN3 binds RAD23 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68547", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.1.-", "l": "\"Other oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.48", "l": "\"staphopain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37887", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": [], "t": []}, {"i": "EC:2.1.1.386", "l": "\"small RNA 2'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52020", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = A + H2O + resolvin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698924", "l": "B Nucleocapsid Assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32768", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371582", "l": "HSBP1 binds HSF1 trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24905", "l": "3',3'-c-di-GMP + H2O <=> 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674022", "l": "BRAP autoubiquitinates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102145", "l": "(3R)-(E)-nerolidol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58472", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20983", "l": "2 bilirubin IXalpha + O2 <=> 2 biliverdin IXalpha + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17660", "l": "an acyl-CoA + dihydroxyacetone phosphate <=> a 1-acylglycerone 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28086", "l": "2 H2O2 + Reactive Blue 5 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": [], "t": []}, {"i": "EC:1.11.1.19", "l": "\"dye decolorizing peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954056", "l": "E2F6 binds TFDP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334827", "l": "SUMO-CRABP2 binds atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68424", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 = (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428625", "l": "Vesicular inhibitory amino acid transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869568", "l": "NPM1 binds TFAP2A homodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813740", "l": "GDE1 hydrolyzes GroPIns (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21106", "l": "25-hydroxycholesterol + A + H2O => AH2 + cholesterol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11386", "l": "2-oxooctadecanoate + H(+) + NADH => (S)-2-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193786", "l": "3,7,24THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39106", "l": "ATP + H2O + sitosterol(in) <=> ADP + H(+) + phosphate + sitosterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684351", "l": "pp1a cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65502", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40914", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029690", "l": "Caspase-6 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60620", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine = choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067667", "l": "IL6 binds IL6R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055054", "l": "fructose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73437", "l": "H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase] => apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20873", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose => (20S)-ginsenoside Rb1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63780", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14263", "l": "6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA => (E)-sinapoyl-CoA + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40963", "l": "4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O", "d": [], "t": []}, {"i": "EC:1.10.3.4", "l": "\"o-aminophenol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29672", "l": "Ca(2+)(in) => Ca(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47548", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate = 3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66032", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42629", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA => 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416358", "l": "G alpha (q) inhibits PI3K alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51512", "l": "H2O + oxamate = NH4(+) + oxalate", "d": [], "t": []}, {"i": "EC:3.5.1.126", "l": "\"oxamate amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20089", "l": "acetyl-CoA + L-leucine = CoA + H(+) + N-acetyl-L-leucine", "d": [], "t": []}, {"i": "EC:2.3.1.66", "l": "\"leucine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50183", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794356", "l": "BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57063", "l": "2''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0099085", "l": "DIF dechlorinase activity", "d": ["Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32739", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75320", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) => chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018769", "l": "2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11718", "l": "a dicarboxylate + NH4(+) => a monoamide of a dicarboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937856", "l": "p-Y-YAP1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030059", "l": "aralkylamine dehydrogenase (azurin) activity", "d": ["Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14366", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate => CO2 + L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58722", "l": "H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide => (S)-nicotine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005134", "l": "interleukin-2 receptor binding", "d": ["Binding to an interleukin-2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53095", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044730", "l": "bone sialoprotein binding", "d": ["Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21885", "l": "H2O + trithionate => H(+) + sulfate + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50646", "l": "3-(3-methylsulfanyl)propylmalate => 2-(3-methylsulfanyl)propylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22720", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.13.1", "l": "\"protein-histidine pros-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26113", "l": "H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69413", "l": "2 glutathione + tert-butyl hydroperoxide => glutathione disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64399", "l": "glycyl-sarcosine(out) + H(+)(out) <=> glycyl-sarcosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58400", "l": "heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77097", "l": "5-S-cysteinyldopaquinone + L-dopa => 5-S-cysteinyldopa + L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995388", "l": "PP2A dephosphorylates BANF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22776", "l": "2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70982", "l": "Fumarate + H2O <=> (S)-Malate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203553", "l": "eNOS binds NOSIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381644", "l": "ER calcium channels open in response to activated PKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49213", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72753", "l": "L-phenylalanine + ochratoxin alpha => H2O + ochratoxin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2471842", "l": "Collagen type XXV ectomain shedding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37189", "l": "1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38808", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15209", "l": "(2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65499", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH <=> 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034941", "l": "pyrrole-2-carboxylate decarboxylase activity", "d": ["Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11897", "l": "7alpha-hydroxycholesterol + NAD(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47758", "l": "2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209215", "l": "CI activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51233", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41737", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) => adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33925", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+) => (1R,4R)-5-oxo-1,2-campholide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49687", "l": "H(+) + NADH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16566", "l": "2-oxoglutarate + L-histidine => 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.314", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004712", "l": "protein serine/threonine/tyrosine kinase activity", "d": ["Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42790", "l": "2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55037", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60664", "l": "H2O + NADPH = NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160072", "l": "ubiquitin ligase complex scaffold activity", "d": ["The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654571", "l": "Activated FGFR1 binds FRS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59466", "l": "H(+) + NADPH + octadecanal => NADP(+) + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69127", "l": "glyoxylate + L-tryptophan <=> glycine + indole-3-pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32507", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22387", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O <=> 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21604", "l": "styrene oxide = 2-phenylacetaldehyde", "d": [], "t": []}, {"i": "EC:5.3.99.7", "l": "\"styrene-oxide isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170978", "l": "p-FRS2:CRKL binds C3G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534096", "l": "METAP1/2 demethylates GNAT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050591", "l": "quinine 3-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + quinine = 3-hydroxyquinine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37004", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47486", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => deoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38906", "l": "a sphingomyelin(in) + ATP + H2O <=> a sphingomyelin(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803425", "l": "TP53 binds ZNF385A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005223", "l": "intracellular cGMP-activated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015137", "l": "citrate transmembrane transporter activity", "d": ["Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390598", "l": "Myosin Binds ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28392", "l": "N(6)-(D-fructosyl)-L-lysine => N(6)-(D-psicosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36750", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46322", "l": "3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2 => 3beta-hydroxy-chol-5-ene-24-oyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2429719", "l": "MCPH1 sequesters condensin II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63187", "l": "NADH + 2 O2 <=> H(+) + NAD(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31130", "l": "3-O-methylgallate + O2 <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22053", "l": "A + H2O + NH4(+) => AH2 + H(+) + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928591", "l": "EPH:EFN tetramers oligomerise (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40290", "l": "ATP + CoA + decanedioate <=> AMP + decanedioyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15881", "l": "ATP + L-seryl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28374", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11687", "l": "methylarsonous acid + S-adenosyl-L-methionine <=> dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.65", "l": "\"sugiol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53249", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68283", "l": "L-seryl-[protein] + pentanoyl-CoA <=> CoA + O-pentanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944232", "l": "Association of procollagen type XII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28730", "l": "Cu(2+)(in) + H(+)(in) <=> Cu(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67406", "l": "carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59723", "l": "D-maltohexaono-1,5-lactone + H2O <=> D-maltohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454916", "l": "The ABCC family mediates organic anion transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35933", "l": "3''-deamino-3''-hydroxykanamycin X + H(+) + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50847", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61622", "l": "[(1->2)-beta-D-mannosyl](n+1) + GDP + H(+) => [(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.6", "l": "\"dipeptidyl-dipeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52454", "l": "16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159250", "l": "ATF7IP binds SETDB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16641", "l": "a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.67", "l": "\"fatty-acyl-ethyl-ester synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878679", "l": "Expression of KLF15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30960", "l": "9,9'-di-cis-zeta-carotene + a quinone => 7,9,9'-tri-cis-neurosporene + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68584", "l": "ATP + H2O + L-tryptophan(out) = ADP + H(+) + L-tryptophan(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018785", "l": "RHOBTB2 binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419197", "l": "Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62243", "l": "a thymidine(6-4)cytidine in DNA <=> a thymine-cytidine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11950", "l": "4-hydroxybenzoate + CoA + H(+) => 4-hydroxybenzoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46261", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036310", "l": "ATP-dependent DNA/DNA annealing activity", "d": ["An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47032", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:2.8.1.13", "l": "\"tRNA-uridine 2-sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030248", "l": "cellulose binding", "d": ["Binding to cellulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24600", "l": "H2O + O2 + sulfite = H2O2 + sulfate", "d": [], "t": []}, {"i": "EC:1.8.3.1", "l": "\"sulfite oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035486", "l": "cytosine/cytosine mispair binding", "d": ["Binding to a double-stranded DNA region containing a C/C mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49948", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9706837", "l": "AR binds AR antagonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114254", "l": "CYCS binds to APAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33682", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.58", "l": "\"longifolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40319", "l": "O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71747", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) = 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34764", "l": "(S,S)-tartrate(out) + succinate(in) => (S,S)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76105", "l": "(11R)-methyl carlactonoate + S-adenosyl-L-homocysteine => (11R)-carlactonoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45570", "l": "[acharan](n) => [heparosan](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58814", "l": "AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48036", "l": "a globoside Gb4Cer (d18:1(4E)) + H2O = a globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003861", "l": "3-isopropylmalate dehydratase activity", "d": ["Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54808", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 = H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12370", "l": "2,5-didehydro-D-gluconate + AH2 => 2-dehydro-D-gluconate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48626", "l": "(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112755", "l": "SOCS3 binds IL6ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18046", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O => alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68872", "l": "(E)-cinnamate + ATP + H(+) + NADPH = (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56019", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31380", "l": "H2O + pyrrole-2-carboxylate => 1H-pyrrole + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58594", "l": "1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938108", "l": "SERPINB13 binds cathepsin L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27304", "l": "3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloro-L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41339", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017447", "l": "MECP2 binds PPARG gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62467", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11518", "l": "CoA + H(+) + succinate => H2O + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33526", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O <=> acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3878123", "l": "Initiation of SAHF formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32554", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-alpha-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63668", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005326", "l": "neurotransmitter transmembrane transporter activity", "d": ["Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63072", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912627", "l": "CBL ubiquitinates PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421482", "l": "hydroxymethylbilane => uroporphyrinogen III + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74726", "l": "Dissociation of insulin from insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40175", "l": "O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18005", "l": "D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.162", "l": "\"erythrulose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40044", "l": "ATP + citrate + L-glutamate => ADP + beta-citrylglutamate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015558", "l": "secondary active p-aminobenzoyl-glutamate transmembrane transporter activity", "d": ["Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid."], "t": []}, {"i": "RHEA:35043", "l": "N-(4-aminobenzoyl)-L-glutamate(in) = N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60371", "l": "urate(out) <=> urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102031", "l": "4-acetamido-4,6-dideoxy-D-galactose transferase activity", "d": ["Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol = H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32952", "l": "sucrose => trehalulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75825", "l": "5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase] => (5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674022", "l": "BRAP autoubiquitinates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27361", "l": "chloride + S-adenosyl-L-methionine = chloromethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40070", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035797", "l": "tellurite methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67787", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65578", "l": "an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30672", "l": "H2O + N,N'-diacetylchitobiose => 2 N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448744", "l": "IL20RA binds IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008673", "l": "2-dehydro-3-deoxygluconokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33853", "l": "GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine => GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15851", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate => 2 Fe(III)-[cytochrome c] + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45696", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) = N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57376", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.166", "l": "\"(S)-N-methylcanadine 1-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60449", "l": "an S-substituted glutathione + H2O => glycine + S-substituted gamma-glutamyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902485", "l": "L-cysteine binding", "d": ["Binding to L-cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559439", "l": "CD14:LPS binds CR3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170120", "l": "Translocation of Cdc25B to the cytoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10810", "l": "(1R,2S)-epoxypropylphosphonate + 2 H2O => (S)-2-hydroxypropylphosphonate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29025", "l": "H(+)(out) + L-fucose(out) => H(+)(in) + L-fucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033740", "l": "hydroxylamine oxidoreductase activity", "d": ["Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427570", "l": "Group 3 - Selective Cl- transport (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031726", "l": "CCR1 chemokine receptor binding", "d": ["Binding to a CCR1 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31524", "l": "2-oxoglutarate + 2 H(+) + O2 => 3 CO2 + ethene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22526", "l": "a carotenoid phi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26086", "l": "(4S)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38353", "l": "3-phenylpyruvate + H(+) + NADH => (R)-3-phenyllactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855187", "l": "IP6 transports from the nucleus to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48360", "l": "a 1,2-saturated fatty acid + H2O2 = a 2-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794347", "l": "Homer1,2,3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68242", "l": "L-methionine(out) + Na(+)(out) => L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210662", "l": "Phosphorylated HOP is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68645", "l": "(2E)-geranyl diphosphate => alpha-thujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051747", "l": "cytosine C-5 DNA demethylase activity", "d": ["Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35511", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202722", "l": "CD48 binds CD244 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62242", "l": "a thymine-cytidine dinucleotide in DNA => a thymidine(6-4)cytidine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53480", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74022", "l": "glycine(out) + L-alanine(in) <=> glycine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37769", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193641", "l": "IKK-beta is recruited (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102633", "l": "flaviolin monooxygenase activity", "d": ["Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 = mompain + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30173", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => hexadecanoyl-[ACP] + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39786", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429767", "l": "Passive I- efflux mediated by SMCT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45266", "l": "(9Z,12Z)-octadecadienoate(in) => (9Z,12Z)-octadecadienoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40157", "l": "22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52111", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000433", "l": "SUMOylation of PML with SUMO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70519", "l": "(R)-octopamine + S-adenosyl-L-methionine = (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627775", "l": "Autophosphorylation of PAK1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29651", "l": "agmatine(in) + L-arginine(out) = agmatine(out) + L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31262", "l": "but-3-ynal + H2O + NAD(+) <=> 3-butynoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735179", "l": "GATA4 and LEF1:CTNNB1 bind the ISL1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77295", "l": "a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26305", "l": "2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde", "d": [], "t": []}, {"i": "EC:1.13.11.74", "l": "\"2-aminophenol 1,6-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20334", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] => ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106386", "l": "(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008926", "l": "mannitol-1-phosphate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59402", "l": "D-2-aminohexanoate => L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60296", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.369", "l": "\"[histone H3]-lysine(27) N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483170", "l": "PS transports from the ER membrane to the IM membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28712", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) => H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674532", "l": "AAMP gene expression is positively regulated by VEGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60135", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41232", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664879", "l": "ATM:PEX5 binds ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72231", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) = chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75281", "l": "an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665989", "l": "DIAPH1 binds RHOA:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67426", "l": "a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22949", "l": "D-tagatofuranose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42501", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24469", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 => H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850797", "l": "SPINK6 binds KLK13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702849", "l": "CALCR binds gepants (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432121", "l": "LDL binds to LRP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40569", "l": "A + dTDP-beta-L-evernitrose + H2O => AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77719", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668714", "l": "RAC1:GTP binds NOX1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24538", "l": "N-formyl-L-kynurenine => L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022871", "l": "protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65830", "l": "diphosphate + nerol => H2O + neryl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193641", "l": "IKK-beta is recruited (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27900", "l": "adenosine + phosphate => 3'-AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65695", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine <=> a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624798", "l": "LBR binds KPNB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804099", "l": "HMGB1 binds LTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22308", "l": "O2 + xylitol = D-xylose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.14", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30705", "l": "CO2 + phenol => H(+) + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622415", "l": "RIP2 binds NEMO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696670", "l": "CHD1L is recruited to GG-NER site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006850", "l": "IL21 receptor JAK phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17294", "l": "2 H(+) + NADH + O2 + precorrin-3A => H2O + NAD(+) + precorrin-3B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650858", "l": "Meglitinides bind ABCC8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32618", "l": "(6E)-8-oxogeraniol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45891", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33680", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70673", "l": "CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] => N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11280", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": [], "t": []}, {"i": "EC:2.1.2.8", "l": "\"deoxycytidylate 5-hydroxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-874087", "l": "SGT1 binds HSP90 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688797", "l": "ATXN3 family cleave Ub chains (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54755", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) <=> dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70306", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76858", "l": "2-aminopentane + H2O + NAD(+) <=> H(+) + NADH + NH4(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827870", "l": "SOX17 and TFAP2C bind the TFAP2C gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351207", "l": "Spermine  => N-acetylated spermine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20992", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.94", "l": "\"tabersonine 16-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20673", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696547", "l": "STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647746", "l": "EML4 trimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12313", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179410", "l": "Association of Nek2A with MCC:APC/C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102569", "l": "FR-33289 synthase activity", "d": ["Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 = FR-33289 + succinate(2-) + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696266", "l": "RND2 binds effectors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050445", "l": "asparagusate reductase activity", "d": ["Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22231", "l": "H(+) + NADH + presqualene diphosphate <=> diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48228", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": [], "t": []}, {"i": "EC:2.3.1.269", "l": "\"apolipoprotein N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12847", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46397", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014456", "l": "GDIs block activation of RHOG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351894", "l": "Caspase mediated cleavage of BAP31 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687625", "l": "ATP binds MLKL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55591", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67741", "l": "N-acetyl-beta-neuraminate => aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40194", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.3", "l": "\"histidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18344", "l": "D-xylono-1,4-lactone + H2O <=> D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25277", "l": "3',5'-cyclic AMP + H2O = AMP + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.53", "l": "\"3',5'-cyclic-AMP phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655142", "l": "RCHY1 binds POLH (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004134", "l": "4-alpha-glucanotransferase activity", "d": ["Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047785", "l": "cortisol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45467", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69907", "l": "2 Na(+)(out) + uridine(out) = 2 Na(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62837", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64674", "l": "butyl 2-(methylsulfanyl)acetate + CoA => 2-(methylsulfanyl)acetyl-CoA + butan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29908", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69628", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461993", "l": "pro-HD5 is cleaved by trypsin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0044683", "l": "methylthiol:coenzyme M methyltransferase activity", "d": ["Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374173", "l": "AGT(34-41) binds to AGTR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799431", "l": "TP53 binds HIPK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875558", "l": "RAPGEF1 binds CRK,CRKL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44190", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14473", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.93", "l": "\"very-long-chain enoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12521", "l": "L-dopa => (E)-caffeate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59940", "l": "2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60685", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) => (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112436", "l": "Formation of Elongin complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.22", "l": "\"4-hydroxyproline betaine 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68928", "l": "ATP + H(+) + heptanoate + NADPH = AMP + diphosphate + heptanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195304", "l": "Association of beta-catenin with the destruction complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.22", "l": "\"coagulation factor IXa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42499", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate <=> 10-deacetyl-2-debenzoylbaccatin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21954", "l": "H(+) + NADPH + progesterone => 5alpha-pregnane-3,20-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749977", "l": "UGT1A6 glucuronates ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44388", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001165", "l": "RNA polymerase I cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69173", "l": "Joining of adjacent Okazaki fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088322", "l": "Defective GNE does not phosphorylate ManNAc to ManNAc-6-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694390", "l": "nsp15 binds RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67317", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine => (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470010", "l": "Dimerization of STATs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050334", "l": "thiaminase activity", "d": ["Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8863727", "l": "STON2 is neddylated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18334", "l": "ATP + oleandomycin => ADP + H(+) + oleandomycin 2'-O-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55142", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + H(+) => D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10501", "l": "butanoyl-CoA + glyoxylate + H2O => 3-ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13848", "l": "dihydroxyfumarate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005436", "l": "sodium:phosphate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093329", "l": "EFNBs bind SDCBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61273", "l": "H2O + L-2-aminopentanoate + O2 => 2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58122", "l": "3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate => ATP + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69816", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51221", "l": "1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22224", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": [], "t": []}, {"i": "EC:2.3.1.159", "l": "\"acridone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51883", "l": "3,4,6-trichlorocatechol + O2 <=> (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46273", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102360", "l": "daphnetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin = UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005124", "l": "scavenger receptor binding", "d": ["Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141000", "l": "histone H4K91 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 4 at the lysine-91 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66208", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 = (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60210", "l": "3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate => 3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035237", "l": "corazonin receptor activity", "d": ["Combining with the neuropeptide corazonin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938108", "l": "SERPINB13 binds cathepsin L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62260", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.213", "l": "\"cytidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757574", "l": "ALB binds PREDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13057", "l": "an N-acylneuraminate 9-phosphate + H2O = an N-acylneuraminate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.29", "l": "\"N-acylneuraminate-9-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102990", "l": "5-n-alk(en)ylresorcinol O-methyltransferase activity", "d": ["Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714580", "l": "SLC6A3 binds DRIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031856", "l": "parathyroid hormone receptor binding", "d": ["Binding to a parathyroid hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874082", "l": "MET phosphorylates PTK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201443", "l": "Type II receptor phosphorylates type I receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047706", "l": "biochanin-A reductase activity", "d": ["Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41414", "l": "1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38497", "l": "a 1,3-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69685", "l": "CHEK2 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694455", "l": "SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170706", "l": "Phosphorylation of  NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74650", "l": "GTP + N-acetyl-D-glucosamine <=> GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37162", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851888", "l": "MET binds SHC1-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50460", "l": "a medium chain fatty acid + ATP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.47", "l": "\"medium-chain-fatty-acid--[acyl-carrier-protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40471", "l": "(2S)-methylpentadecanoyl-CoA + O2 = 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23988", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.83", "l": "\"LL-diaminopimelate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430347", "l": "MigFilin associates with Filamin and F-actin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48405", "l": "apo-[aryl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64616", "l": "(E)-coniferol + acetyl-CoA = (E)-coniferyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863007", "l": "p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49395", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33394", "l": "C20 sphinganine 1-phosphate + H2O <=> C20 sphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20023", "l": "amidinoproclavaminate + CO2 + succinate => 2-oxoglutarate + deoxyamidinoproclavaminate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44001", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 => 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17425", "l": "CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.51", "l": "\"pyruvate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655248", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804383", "l": "PRMT5 methylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467775", "l": "Autocleavage of ESPL1 (Separase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65257", "l": "AH2 + O2 + verruculide C => A + H2O + verruculide C epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29042", "l": "ATP + H2O + L-aspartate(out) <=> ADP + H(+) + L-aspartate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18110", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10229", "l": "citrate => cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62392", "l": "levoglucosan + NAD(+) = 3-dehydrolevoglucosan + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.425", "l": "\"levoglucosan dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2059926", "l": "NPHP4 protein binds LATS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27314", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 = 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": [], "t": []}, {"i": "EC:1.13.12.17", "l": "\"dichloroarcyriaflavin A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606349", "l": "Mis18 complex binds the centromere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070139", "l": "SUMO-specific endopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34784", "l": "a 3alpha-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549129", "l": "OCT1 transports organic cations into hepatic cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73289", "l": "(2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67181", "l": "ATP + glycine + L-glutamyl-[protein] => ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201521", "l": "ALK autophosphorylation  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15405", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) = [(3R)-hydroxybutanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177922", "l": "EGFR dimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921155", "l": "p-STAT5 dissociates from the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380203", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58365", "l": "a medium-chain primary fatty alcohol + NADP(+) => a medium-chain fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69474", "l": "a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9828175", "l": "Formation of the NSL complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.158", "l": "\"alpha-agarase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77403", "l": "2-methylpropanal + hydrogen cyanide = (2S)-2-hydroxy-3-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031869", "l": "prostacyclin receptor binding", "d": ["Binding to a prostacyclin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21967", "l": "an acylcholine + H2O <=> a carboxylate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18305", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate", "d": [], "t": []}, {"i": "EC:2.3.1.44", "l": "\"N-acetylneuraminate 4-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939204", "l": "ESTG binds ESR1:chaperone complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050148", "l": "nucleotide diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.175", "l": "\"glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23239", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O <=> H(+) + L-glutamyl-[protein] + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222546", "l": "AP-1 complex stimulates KDM6B transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11705", "l": "2 H(+) + N-(carboxyaminomethyl)urea => CO2 + N-(aminomethyl)urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72213", "l": "(1S,4S)-camphor + H(+) + NADH => (+)-isoborneol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76144", "l": "picrinine + S-adenosyl-L-methionine => ervincine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20312", "l": "2 H2O2 <=> 2 H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11411", "l": "H(+) + H2O + riboflavin <=> lumichrome + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684321", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430180", "l": "NCK recruits WASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090612", "l": "cAMP deaminase activity", "d": ["Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120242", "l": "2-iminobutanoate deaminase activity", "d": ["Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15255", "l": "CO2 + itaconate => cis-aconitate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700164", "l": "Active ALK phosphorylates FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55626", "l": "3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42726", "l": "2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60974", "l": "H(+) + hexanal + NADH => hexan-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59516", "l": "acetylsalicylate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41879", "l": "(3R)-hydroxydodecanoyl-[ACP] <=> (2E)-dodecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40170", "l": "hexadecanoyl-CoA + O2 <=> (2E)-hexadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73608", "l": "CTP(out) + dCTP(in) => CTP(in) + dCTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53646", "l": "(+)-corvol ether B + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990080", "l": "2-phenylethylamine receptor activity", "d": ["Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30914", "l": "a sphingomyelin + H2O <=> a carboxylate + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60023", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65311", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28874", "l": "D-fructuronate(in) + H(+)(in) <=> D-fructuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51671", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77283", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75833", "l": "5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228408", "l": "Retrograde transport of internalized tetX HC:LC:gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36422", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58901", "l": "1-carboxybiuret + H2O => NH4(+) + urea-1,3-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390674", "l": "ADRB1 bind ADR,NAd (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50288", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18054", "l": "H2O + paraoxon => 4-nitrophenol + diethylphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21033", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate => acceptor beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.12", "l": "\"dihydrolipoyllysine-residue acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36185", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33600", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25633", "l": "laricitrin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45650", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18149", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47933", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) => (2S)-3-sulfolactate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0097599", "l": "xylanase activity", "d": ["Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45445", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40544", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603784", "l": "PEX19:class I PMP binds PEX3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25366", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) <=> H(+) + momilactone A + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18168", "l": "biphenyl + H(+) + NADH + O2 <=> (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47178", "l": "(2E)-butenoyl-CoA + H2O => (2R)-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14051", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45791", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol <=> 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43647", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042010", "l": "interleukin-15 receptor activity", "d": ["Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12139", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) <=> a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72740", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12332", "l": "ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.7", "l": "\"ABC-type Fe(3+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67133", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051995", "l": "Se-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13674", "l": "[protein-PII]-L-tyrosine + UTP => [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67523", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734730", "l": "ORC1 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050635", "l": "acridone synthase activity", "d": ["Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H+ + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46472", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38805", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822539", "l": "VWF multimer binds to collagen type I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22696", "l": "AH2 + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone", "d": [], "t": []}, {"i": "EC:1.14.99.12", "l": "\"androst-4-ene-3,17-dione monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014296", "l": "RAC2 GEFs activate RAC2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193700", "l": "p75NTR ICD signals to NF-kB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381612", "l": "GLP1R binds GLP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0019842", "l": "vitamin binding", "d": ["Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56120", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791144", "l": "Expression of EXTL3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007447", "l": "E2F6 forms the PRC1L4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250264", "l": "TXNIP binds reduced thioredoxin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49040", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine = (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.330", "l": "\"5'-demethylyatein 5'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167983", "l": "C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76770", "l": "emodin + S-adenosyl-L-methionine <=> physcion + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836449", "l": "p-PKR dimer phosphorylates HIV tat (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007647", "l": "E2F6 binds CBX5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805126", "l": "AURKB phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847977", "l": "FRK phosphorylates PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16784", "l": "a fatty acyl-CoA + H2O <=> a fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54164", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202233", "l": "Inactivation of Lck by Csk (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76383", "l": "carnosine(out) + n H(+)(out) = carnosine(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032532", "l": "NTRK2-bound FYN autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63221", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine => 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65616", "l": "A + cholest-4-en-3-one + H2O = 25-hydroxycholest-4-en-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29100", "l": "a menaquinone + 5 H(+)(in) + NADH => a menaquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706837", "l": "AR binds AR antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29669", "l": "H2O(out) => H2O(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76465", "l": "4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2 => 4-O-(beta-D-glucosyl)-(E)-coniferol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47788", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62320", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-isomalbrancheamide B + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981355", "l": "RASA1 binds RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61344", "l": "H2O + L-serine + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008140", "l": "cAMP response element binding protein binding", "d": ["Binding to a cAMP response element binding protein (a CREB protein)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10181", "l": "(6R)-10-formyltetrahydrofolate + H2O + NADP(+) => (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004481", "l": "methylene-fatty-acyl-phospholipid synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654603", "l": "Activated FGFR2 binds FRS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12184", "l": "(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.76", "l": "\"(S,S)-butanediol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005113", "l": "patched binding", "d": ["Binding to a patched (ptc) protein, a receptor for hedgehog proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035243", "l": "protein-arginine omega-N symmetric methyltransferase activity", "d": ["Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27919", "l": "H2O + NADP(+) + propanal => 2 H(+) + NADPH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139941", "l": "Binding of IP3 to IP3 receptor (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58097", "l": "1-tetracosanoylglycerol + H2O => glycerol + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48330", "l": "GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E)) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046538", "l": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction mechanism uses 2,3-bisphosphoglycerate as a phosphate donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31557", "l": "(3S)-3-aminobutanoyl-CoA + acetoacetate => (5S)-5-amino-3-oxohexanoate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16644", "l": "a long-chain fatty acyl ethyl ester + H2O <=> a long-chain fatty acid + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75482", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) <=> S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62923", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol <=> 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051449", "l": "thyrotropin-releasing hormone binding", "d": ["Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9846477", "l": "A4GALT transfers galactose to LacCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68451", "l": "13-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.5", "l": "\"apyrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46000", "l": "adenosine + H(+) + tuberculosinyl diphosphate = 1-tuberculosinyladenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37300", "l": "H2O + L-alanyl-L-threonine => L-alanine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68980", "l": "NADP(+) + tauroursodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033240", "l": "PEX5L binds PEX7:Cargo protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034931", "l": "1-hydroxypyrene methyltransferase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40641", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247569", "l": "PADI4 deiminates Histones (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65753", "l": "2-oxoglutarate + L-glutamate + O2 => (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67307", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> H2O2 + myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71351", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050469", "l": "sabinene-hydrate synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = diphosphate + sabinene hydrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48336", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44696", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034917", "l": "2-methylhex-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299297", "l": "Activation of THIK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29826", "l": "chloride(in) <=> chloride(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65099", "l": "a 2-acylglycerol + hexadecanoyl-CoA <=> a 1-hexadecanoyl-2-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003912", "l": "DNA nucleotidylexotransferase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60688", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) = (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.103", "l": "\"phosphoethanolamine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19416", "l": "ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786190", "l": "CMBL hydrolyses OM to OLMS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10025", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001406", "l": "glycerophosphodiester transmembrane transporter activity", "d": ["Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57700", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661419", "l": "ALB binds extracellular heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809663", "l": "Formation of hair keratin fibres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10202", "l": "(2E)-2-butenoate + H(+) + NADH => butanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928657", "l": "MMP2,9 cleave EPHB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35482", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57176", "l": "L-arginyl-[protein] + methylglyoxal = N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648268", "l": "HTR1A binds HTR1A antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40681", "l": "1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419490", "l": "Binding of ATP to P2X receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67099", "l": "2-oxoglutarate + asnovolin A + 2 O2 <=> CO2 + fumigatonoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51543", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34468", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + valerena-4,7(11)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909738", "l": "SHP1 and SHP2 bind the common beta chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68467", "l": "2-butyloctyl sulfate + H2O <=> 2-butyloctan-1-ol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209823", "l": "Tyrosine is hydroxylated to dopa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50294", "l": "all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009374", "l": "biotin binding", "d": ["Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032577", "l": "phosphatidylcholine:cardiolipin O-linoleoyltransferase activity", "d": ["Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987120", "l": "JAK1 binds IFNLR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395801", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199169", "l": "MHC Class I interacts with CD160 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16206", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46308", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67071", "l": "AH2 + chermesin D methyl ester <=> A + asnovolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63826", "l": "aspulvinone E + H2O => 2 3-(4-hydroxyphenyl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49417", "l": "ADP + alpha-D-ribose 1-phosphate => alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66983", "l": "2-methylbutanoyl-CoA + H2O <=> 2-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68113", "l": "H2O + propanamide => NH4(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404134", "l": "RBP4:atROL binds TTR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483219", "l": "PC is exchanged with PI by PITPNB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508282", "l": "SYK is a substrate for JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24240", "l": "A + AMP + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + AH2", "d": [], "t": []}, {"i": "EC:1.8.99.2", "l": "\"adenylyl-sulfate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73693", "l": "3'-AMP(in) + phosphate(out) => 3'-AMP(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169394", "l": "ISGylation of IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19754", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23246", "l": "H(+) + norspermidine + S-methyl-5'-thioadenosine => propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.242", "l": "\"3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.14", "l": "\"chlorophyllase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047241", "l": "lipopolysaccharide N-acetylmannosaminouronosyltransferase activity", "d": ["Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34327", "l": "4-nitrophenol + H(+) + NADPH + O2 = 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.14.13.167", "l": "\"4-nitrophenol 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004312", "l": "fatty acid synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050002", "l": "D-proline reductase (dithiol) activity", "d": ["Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0140102", "l": "catalytic activity, acting on a rRNA", "d": ["Catalytic activity that acts to modify a ribosomal RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45163", "l": "3-oxopropanoate + H(+) <=> acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40840", "l": "FAD + H(+) + nonanoyl-CoA => (2E)-nonenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64766", "l": "2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol => S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18992", "l": "H(+) + L-valine <=> 2-methylpropan-1-amine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42198", "l": "(9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34210", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate <=> beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27816", "l": "acetate(out) + Na(+)(out) => acetate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72733", "l": "UDP-alpha-D-glucose(out) + UMP(in) => UDP-alpha-D-glucose(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48851", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54916", "l": "9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062158", "l": "chloride:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61109", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64811", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine <=> CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789042", "l": "Hydroxyl-initiated lipid peroxidation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76609", "l": "(12Z,15Z)-10-hydroxyoctadecadienoate => (9Z,12Z,15Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56810", "l": "adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810376", "l": "ING2 binds PI5P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003998", "l": "acylphosphatase activity", "d": ["Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022141", "l": "Prolysyl oxidase activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76153", "l": "18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53914", "l": "CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein] => butanoyl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49879", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70139", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51092", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160046", "l": "oxalate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + oxalate(in) = chloride(in) + oxalate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65243", "l": "(11Z)-octadecenoyl-CoA + H2O <=> (11Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55304", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58749", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine => H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070967", "l": "coenzyme F420 binding", "d": ["Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444661", "l": "HCAR2 binds HCAR2 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795473", "l": "PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186771", "l": "RNF111 binds SMAD7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944218", "l": "Association of procollagen type VIII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61530", "l": "a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24074", "l": "12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034563", "l": "2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227695", "l": "NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13132", "l": "cis-4-coumarate + UDP-alpha-D-glucose <=> 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12167", "l": "3'-phosphoadenylyl sulfate + a phenol <=> adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669854", "l": "KIT binds type II TKIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62478", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749609", "l": "BCHE hydrolyzes ASA- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928578", "l": "EPH receptors autophosphorylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12868", "l": "1-methyladenosine + H2O <=> 1-methyladenine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296326", "l": "HCAR1 binds LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32544", "l": "(2E)-geranyl diphosphate + H2O => 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16827", "l": "ADP + H(+) + UMP => ATP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21588", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.38", "l": "\"N-acetyl-gamma-glutamyl-phosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694421", "l": "PP6 dephosphorylates SEC24 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71143", "l": "3-hydroxyhispidin + O2 = (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12106", "l": "7,8-dihydrofolate + dTMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158860", "l": "SULT1A1 dimer sulfonates NHABP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033784", "l": "senecionine N-oxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + senecionine = H2O + NADP+ + senecionine N-oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380316", "l": "Association of NuMA with microtubules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39000", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28339", "l": "(R)-carnitinyl-CoA => crotonobetainyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25748", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008822", "l": "PPM1D dephosphorylates RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72576", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172666", "l": "RB1 binds condensin II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30490", "l": "H(+) + N,N-dihydroxy-L-isoleucine <=> (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69005", "l": "Cdc6 protein is phosphorylated by CDK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73970", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015313", "l": "fluconazole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905057", "l": "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73243", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether = cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42549", "l": "uridine(746) in 23S rRNA => pseudouridine(746) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340214", "l": "CYGB binds O2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13876", "l": "(+)-copalyl diphosphate <=> abieta-7,13-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38729", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70383", "l": "3-oxosphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635845", "l": "GLI proteins bind CDC73 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54769", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48757", "l": "erythritol + NAD(+) => D-erythrulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419011", "l": "Transhomodimerization of Nectins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40220", "l": "H2O + malonyl-CoA => CoA + H(+) + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420977", "l": "Ca permeable AMPA receptor ligand binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20310", "l": "2 H2O2 => 2 H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52759", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36724", "l": "2-phenylethylamine + A + H2O => 2-phenylacetaldehyde + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106328", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334794", "l": "FABPs bind LCFAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63011", "l": "(6Z)-octadecenamide + H2O <=> (6Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102529", "l": "apigenin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate = S-adenosyl-L-homocysteine + genkwanin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032558", "l": "adenyl deoxyribonucleotide binding", "d": ["Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71854", "l": "glycocholate(out) <=> glycocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097365", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209221", "l": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611852", "l": "ADRB3 bind ADR,NAd (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429441", "l": "SYK activation by SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13403", "l": "(2Z,6E)-farnesol => (2E,6E)-farnesol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52431", "l": "12-oxo-leukotriene B4 + H(+) + NADH <=> 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21358", "l": "H(+) + L-ribulose + NADH => L-arabinitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71048", "l": "glycine(in) + L-phenylalanine(out) => glycine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46250", "l": "(14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57997", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39532", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641134", "l": "SMURF2 binds AXIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102469", "l": "naringenin 2-hydroxylase activity", "d": ["Catalysis of the reaction: (S)-naringenin + NADPH + O2 = 2-hydroxynaringenin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69496", "l": "decan-1-ol + O2 = decanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653974", "l": "Ragulator binds Rag dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46287", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64802", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+) => NAD(+) + S-(2-aminoethyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654159", "l": "Activated FGFR2 binds PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51335", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005213", "l": "structural constituent of egg chorion", "d": ["The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49324", "l": "(5R,6S)-5,6-epoxi-capsanthin = all-trans-capsorubin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710354", "l": "GSDME (1-270) binds cardiolipin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0000977", "l": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11251", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27812", "l": "(2Z,6Z)-farnesyl diphosphate + 2 diphosphate => dimethylallyl diphosphate + 2 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36553", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034057", "l": "RNA strand-exchange activity", "d": ["Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68084", "l": "GTP + L-histidyl-[RNA ligase] = diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.26", "l": "\"4-phytase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34560", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) => 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38480", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392870", "l": "Gs activation by prostacyclin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53244", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57319", "l": "ATP + cytidine 5'-diphosphoramidate <=> ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64480", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050264", "l": "rifamycin-B oxidase activity", "d": ["Catalysis of the reaction: 2 H+ + O2 + rifamycin B = H2O2 + rifamycin O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46003", "l": "adenosine + H(+) + tuberculosinyl diphosphate <=> 1-tuberculosinyladenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39502", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008118", "l": "N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62245", "l": "a cytidine(6-4)thymidine in DNA => a cytidine-thymine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611851", "l": "ADRB2 bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937728", "l": "SRC phosphorylates RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786190", "l": "CMBL hydrolyses OM to OLMS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237129", "l": "Acireductone is created (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25437", "l": "(2E,6E)-farnesyl diphosphate => (E,R)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68595", "l": "ORC2 binds ORC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30258", "l": "2 a ubiquinol + O2 <=> 2 a ubiquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59198", "l": "AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114683", "l": "Phosphorylation of Platelet Sec-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351948", "l": "Mitochondrial recruitment of Drp1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52302", "l": "(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839772", "l": "YME1L1 binds mitochondrial intermembrane space proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41518", "l": "H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase] => O2 + phylloquinone + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65472", "l": "2-methylbutanoyl-CoA + ethanol = CoA + ethyl 2-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797803", "l": "PTPRD binds SLITRK1-6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47281", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757574", "l": "ALB binds PREDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41310", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.198", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634850", "l": "NPAS4 binds ARNT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60345", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20520", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63527", "l": "2-propylphenol + H(+) + NADH + O2 <=> 3-propylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669250", "l": "PAK1 phosphorylates FLNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77390", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9828175", "l": "Formation of the NSL complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602473", "l": "Autocatalytic activation of MMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29070", "l": "formate + H(+) + menaquinone-8 <=> CO2 + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44639", "l": "2,4-dinitroanisole + H2O <=> 2,4-dinitrophenol + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77081", "l": "Formation of the CE:GMP intermediate complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322429", "l": "XIAP monoubiquinates TLE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.139", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939204", "l": "ESTG binds ESR1:chaperone complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12234", "l": "[thioredoxin]-dithiol + glycine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635842", "l": "ULK3 phosphorylates GLI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13511", "l": "diphosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390649", "l": "CHRM1,3,5 bind acetylcholine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617485", "l": "HOXB2 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22941", "l": "ATP + L-arginine => ADP + H(+) + N(omega)-phospho-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689861", "l": "Recruitment of XPA and release of CAK  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49312", "l": "2-trans,4-trans-xanthoxin + NAD(+) = 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654569", "l": "Activated FGFR1 binds FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23019", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) <=> (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102671", "l": "6a-hydroxymaackiain-3-O-methyltransferase activity", "d": ["Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = H+ + (+)-pisatin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202724", "l": "P-selectin binds P-selectin ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.-.-", "l": "\"Acting on the CH-CH group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35615", "l": "hydroxyacetone + NAD(+) = H(+) + methylglyoxal + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14412", "l": "cysteamine + O2 <=> H(+) + hypotaurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28841", "l": "H(+)(in) + Zn(2+)(out) => H(+)(out) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67890", "l": "3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58435", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) <=> (E)-4-oxonon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70371", "l": "3-oxosphinganine + decanoyl-CoA = CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56020", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69911", "l": "adenosine(out) + 2 Na(+)(out) = adenosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65792", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64366", "l": "(15S)-15-hydroperoxy-prostaglandin E2 => prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74297", "l": "n H(+)(in) + serotonin(out) => n H(+)(out) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804741", "l": "MDM2 forms homo- or heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50401", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA => CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374662", "l": "Translocation of Ezrin to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51693", "l": "prephenate + S-adenosyl-L-methionine => 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47115", "l": "chenodeoxycholate + glycine <=> glycochenodeoxycholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14080", "l": "3-oxopropanoate + L-alanine <=> beta-alanine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783530", "l": "gp130:JAKs bind CNTFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28110", "l": "chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.94", "l": "\"adenosyl-chloride synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938930", "l": "RUNX1 binds ELF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70838", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) <=> L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52765", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008297", "l": "single-stranded DNA exodeoxyribonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41654", "l": "2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+) => aclacinomycin S + dTDP-2-deoxy-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159771", "l": "Furin cleaves pro-protein C to protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37831", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534365", "l": "Slo3 Potassium Transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11406", "l": "UDP-alpha-D-galacturonate => UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29951", "l": "H(+)(in) + uridine(in) = H(+)(out) + uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12540", "l": "ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": [], "t": []}, {"i": "EC:6.1.1.7", "l": "\"alanine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047179", "l": "platelet-activating factor acetyltransferase activity", "d": ["Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047089", "l": "dihydrochelirubine 12-monooxygenase activity", "d": ["Catalysis of the reaction: dihydrochelirubine + H+ + NADPH + O2 = 12-hydroxydihydrochelirubine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46270", "l": "a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168038", "l": "Collagen type XV restin release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611751", "l": "β1,2-agonists bind ADRB1,2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430308", "l": "PARVB interacts with Alpha-actinin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2430535", "l": "MASTL phosphorylates ENSA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35701", "l": "(2S-3S)-versiconal hemiacetal + H(+) + NADPH => (S)-versiconol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62714", "l": "H2O + NADP(+) + stemphyloxin I => betaenone C + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45377", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953037", "l": "E2F8 forms homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40902", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41063", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196964", "l": "RFK:Mg2+ phosphorylates RIB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10050", "l": "acetate + H(+) + L-methionine => methanethiol + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35702", "l": "(S)-versiconol + NADP(+) <=> (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.3.-", "l": "\"Oximinotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23969", "l": "(E)-coniferaldehyde + H2O + NAD(+) => (E)-ferulate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64586", "l": "2-hydroxyethane-1-sulfonate(in) + Na(+)(in) => 2-hydroxyethane-1-sulfonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54362", "l": "3-methylbutanal + CO2 => 4-methyl-2-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042925", "l": "benzoate transmembrane transporter activity", "d": ["Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other."], "t": []}, {"i": "RHEA:32811", "l": "benzoate(in) = benzoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009028", "l": "tartronate-semialdehyde synthase activity", "d": ["Catalysis of the reaction: 2 glyoxylate + H+ = 2-hydroxy-3-oxopropanoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008266", "l": "poly(U) RNA binding", "d": ["Binding to a sequence of uracil residues in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76374", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) <=> n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46711", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] <=> AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004451", "l": "isocitrate lyase activity", "d": ["Catalysis of the reaction: isocitrate = glyoxylate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57055", "l": "3-oxoisoapionate + H(+) <=> CO2 + L-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000327", "l": "PLK1 phosphorylates BORA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75942", "l": "4-aminobutanoate + L-arginine <=> 4-guanidinobutanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61484", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20460", "l": "D-arabinose + NAD(+) <=> D-arabinono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54954", "l": "AMP + diphosphate + nonanoyl-CoA => ATP + CoA + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42350", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706319", "l": "Active FLT3 binds to SLA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72061", "l": "glycochenodeoxycholate(in) + 2 Na(+)(in) => glycochenodeoxycholate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873850", "l": "STARD5 binds DCA, LCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013145", "l": "RAC1 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624952", "l": "Assembly of the retrograde IFT train (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58152", "l": "H2O + NAD(+) + phosphonoacetaldehyde = 2 H(+) + NADH + phosphonoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015052", "l": "beta3-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604499", "l": "Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45900", "l": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48199", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37072", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73050", "l": "guanidinoacetate(in) <=> guanidinoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12943", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76236", "l": "a tRNA with a 3' CCA end + ATP + 2 CTP => a tRNA with a 3' CCACCA end + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62394", "l": "3-dehydrolevoglucosan + H(+) + NADH => levoglucosan + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16410", "l": "1,2-dihydrovomilenine + NADP(+) => H(+) + NADPH + vomilenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58532", "l": "15alpha-stemmadenine intermediate I + H2O = akuammicine + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21029", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.92", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52516", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045015", "l": "HDEL sequence binding", "d": ["Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52890", "l": "H(+) + NADPH + nitrosobenzene => N-phenylhydroxylamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43568", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140587", "l": "chromatin loop anchoring activity", "d": ["Bridging together two DNA loop anchors together, maintaining a chromatin loop."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67676", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52429", "l": "12-oxo-leukotriene B4 + H(+) + NADH => 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34930", "l": "H(+) + NADPH + selenodiglutathione <=> glutathione + glutathioselenol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909732", "l": "Phosphorylation of STAT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75083", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034928", "l": "1-hydroxypyrene 6,7-monooxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74130", "l": "peonidin + UDP-alpha-D-galactose <=> peonidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13763", "l": "S-adenosyl-L-homocysteine + S-methyl-L-methionine => L-methionine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47050", "l": "3-dehydroshikimate + a quinol => a quinone + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0003913", "l": "DNA photolyase activity", "d": ["Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140853", "l": "cholesterol-protein transferase activity", "d": ["Catalysis of the transfer of a cholesterol to an acceptor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15269", "l": "L-xylo-hex-3-ulonolactone = H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20954", "l": "beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44146", "l": "CoA + H(+) + N(alpha)-acetyl-L-methionine => acetyl-CoA + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19823", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103102", "l": "UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate = H+ + 7-methylthioheptyldesulfoglucosinolate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672170", "l": "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220952", "l": "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114552", "l": "Thrombin-activated PARs activate G12/13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48245", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48996", "l": "3-methylcatechol + O2 = 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20628", "l": "2 Fe(III)-[cytochrome c3] + H2 <=> 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849908", "l": "SALM4 binds flotillin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24484", "l": "NAD(+) + sulcatol = H(+) + NADH + sulcatone", "d": [], "t": []}, {"i": "EC:1.1.1.260", "l": "\"sulcatone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14912", "l": "L-gulonate + NADP(+) <=> aldehydo-D-glucuronate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36234", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52562", "l": "3-dehydro-D-erythronate => 2-dehydro-D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004668", "l": "protein-arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805740", "l": "SETD8 methylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51364", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.353", "l": "\"versiconal hemiacetal acetate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51896", "l": "H2O + N(1)-acetylspermine = acetate + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68580", "l": "ATP + H2O + L-kynurenine(out) = ADP + H(+) + L-kynurenine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770141", "l": "Formation of the Spliceosomal C* complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40622", "l": "H2O + tridodecanoylglycerol <=> 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29011", "l": "2-oxoglutarate(in) + H(+)(in) = 2-oxoglutarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32662", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) <=> (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58482", "l": "ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate => a cytidine in mRNA + acetyl-CoA + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008849", "l": "enterochelin esterase activity", "d": ["Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46857", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198621", "l": "AKT phosphorylates caspase-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659554", "l": "KCNQ4 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77555", "l": "a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638006", "l": "ARL3 hydrolyzes GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654404", "l": "Activated FGFR2 binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15180", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52938", "l": "(3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP] => 3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450325", "l": "c-FOS activation by phospho ERK1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61100", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102100", "l": "mycothiol-arsenate ligase activity", "d": ["Catalysis of the reaction: arsenate + mycothiol = mycothiol-arsenate conjugate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56673", "l": "dihydro-4-coumaroyl-CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60794", "l": "3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A53 + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62760", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090499", "l": "pimelyl-[acyl-carrier protein] methyl ester esterase activity", "d": ["Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41426", "l": "formate + grixazone A + H(+) + 3 H2O => 2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75828", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14461", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.193", "l": "\"sarsapogenin 3beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74342", "l": "O-3-methylbutanoyl-(R)-carnitine(in) <=> O-3-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788622", "l": "p-Y-STATs dimerize (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27834", "l": "a menaquinone + succinate = a menaquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47044", "l": "3-dehydrocarnitine + acetyl-CoA = acetoacetate + N,N,N-trimethylglycyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71274", "l": "H(+)(in) + thiamine(out) <=> H(+)(out) + thiamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411373", "l": "NLK translocates to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33368", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874685", "l": "CBL binds MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60306", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24013", "l": "gamma-tocopherol + S-adenosyl-L-methionine => (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55533", "l": "H(+) + H2O + L-phenylalanine + O2 => 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68138", "l": "(R)-1-phenylethanol + NADP(+) => acetophenone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10836", "l": "NADPH + O2 + questin = demethylsulochrin + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.43", "l": "\"questin monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17043", "l": "AMP + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57511", "l": "H2O + NADP(+) + staphylopine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54701", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382057", "l": "Release of novel PDGFs as latent factors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684273", "l": "3CLp cleaves pp1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250220", "l": "Homodimerization of ERBB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55298", "l": "13-cis-retinyl hexadecanoate + CoA => 13-cis-retinol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950342", "l": "EBI3:CANX binds IL27 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0047023", "l": "androsterone dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60904", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47765", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA => 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10870", "l": "a triacyl-sn-glycerol + CoA => a 1,2-diacyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377640", "l": "Autophosphorylation of SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508292", "l": "SYK binds IL2RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005122", "l": "torso binding", "d": ["Binding to a torso (tor) protein, a receptor tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23136", "l": "a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879459", "l": "F-actin capping protein is a heterodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090704", "l": "nicotinate-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65219", "l": "3-oxododecanoyl-CoA + H2O <=> 3-oxododecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45658", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29368", "l": "CMP + H2O => cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63772", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016316", "l": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0035514", "l": "DNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68743", "l": "7-oxocholesterol + H(+) + NADPH <=> 7alpha-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10167", "l": "(2R)-2-phosphoglycerate <=> H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12870", "l": "(2E)-geranyl diphosphate => (4S)-limonene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23191", "l": "NAD(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008774", "l": "acetaldehyde dehydrogenase (acetylating) activity", "d": ["Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2467775", "l": "Autocleavage of ESPL1 (Separase) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17716", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18493", "l": "benzoyl-CoA + glycine = CoA + H(+) + N-benzoylglycine", "d": [], "t": []}, {"i": "EC:2.3.1.71", "l": "\"glycine N-benzoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32764", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine => (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352059", "l": "SLC6A15-mediated amino acid uptake (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12619", "l": "ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => ATP + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55140", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102858", "l": "1-18:2-2-18:3-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61883", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47430", "l": "3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59813", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033935", "l": "oligoxyloglucan beta-glycosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781009", "l": "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001565", "l": "phorbol ester receptor activity", "d": ["Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430311", "l": "Rsu-1 interacts with Pinch1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797554", "l": "ABP1 binds SHANK proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602466", "l": "Activation of MT-MMPs by FURIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42657", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O => diphthine-[translation elongation factor 2] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34446", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018591", "l": "methyl tertiary butyl ether 3-monooxygenase activity", "d": ["Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086410", "l": "CDK1 phosphorylates BORA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9689680", "l": "IFNG dimer binds IFNG inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37939", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27670", "l": "1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912727", "l": "CBL binds VAV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63124", "l": "H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46881", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47357", "l": "an octanoate ester + H2O => an aliphatic alcohol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990955", "l": "G-rich single-stranded DNA binding", "d": ["Binding to G-rich, single-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42808", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) = 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite", "d": [], "t": []}, {"i": "EC:1.8.98.3", "l": "\"sulfite reductase (coenzyme F420)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73219", "l": "L-xylopyranose(out) + 2 Na(+)(out) = L-xylopyranose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18317", "l": "an L-alpha-amino acid = a D-alpha-amino acid", "d": [], "t": []}, {"i": "EC:5.1.1.10", "l": "\"amino-acid racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32050", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032090", "l": "Pyrin domain binding", "d": ["Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61832", "l": "sitosterol + UDP-alpha-D-glucose = H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47958", "l": "H(+) + maleate + pyruvate => 3-maleylpyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16955", "l": "L-glutamate + N-succinyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-succinyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46487", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25925", "l": "A + H2O + quinolin-8-ol => 8-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102572", "l": "N-glutamylanilide hydrolase activity", "d": ["Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981353", "l": "RASA1 stimulates RAS GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0036374", "l": "glutathione hydrolase activity", "d": ["Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18819", "l": "acetate + malonyl-CoA => acetyl-CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62102", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42691", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide <=> A + ergothioneine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047747", "l": "cholate-CoA ligase activity", "d": ["Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13542", "l": "H2O + tetrathionate => H(+) + sulfate + sulfur + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35110", "l": "3-nitrotyramine + H2O + O2 <=> 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13109", "l": "2-acetamidofluorene + H2O + NAD(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39267", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70063", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12559", "l": "6-phospho-D-glucono-1,5-lactone + H2O <=> 6-phospho-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28655", "l": "glutathione S,S-dioxide + H2O = glutathione + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39746", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68761", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13094", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193656", "l": "p75NTR interacts with RIP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59030", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => (Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16818", "l": "6-phospho-D-gluconate + NADP(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39315", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA = (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.-", "l": "\"In P-halide compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448673", "l": "Formation of caspase-1 p10/p20 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937814", "l": "RUNX3 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856189", "l": "TNFSF8 binds TNFRSF8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50054", "l": "ADP + H(+) + phosphate + taurocholate(out) => ATP + H2O + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404200", "l": "IGF1,2 binds IGF1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63213", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal => 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15562", "l": "S-adenosyl-L-methionine + sterigmatocystin => 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018763", "l": "hydroxydechloroatrazine ethylaminohydrolase activity", "d": ["Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64054", "l": "CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine => (13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.82", "l": "\"glutamyl endopeptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25026", "l": "H(+) + H2O + S-methyl-5'-thioadenosine => NH4(+) + S-methyl-5'-thioinosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10816", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside", "d": [], "t": []}, {"i": "EC:3.2.1.63", "l": "\"1,2-alpha-L-fucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46420", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49000", "l": "aurachin C + H(+) + NADH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74462", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047930", "l": "glucosaminate ammonia-lyase activity", "d": ["Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018688", "l": "DDT 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197690", "l": "Detachment of WASP/WAVE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686483", "l": "Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41423", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 <=> CO2 + grixazone B + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55483", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26478", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11633", "l": "AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51832", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65940", "l": "(R)-glycerate + GDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38758", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140585", "l": "promoter-enhancer loop anchoring activity", "d": ["Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419334", "l": "Melatonin receptors can bind melatonin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624624", "l": "FBXO32 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16657", "l": "H2O + inosine = D-ribose + hypoxanthine", "d": [], "t": []}, {"i": "EC:3.2.2.2", "l": "\"inosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76200", "l": "oxalate(in) => oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76732", "l": "a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione => a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169406", "l": "ISGylation of host proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050032", "l": "L-rhamnonate dehydratase activity", "d": ["Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9736953", "l": "FURIN translocates to the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507875", "l": "Aquaporins passively transport urea into cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56484", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] = gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044024", "l": "histone H2AS1 kinase activity", "d": ["Catalysis of the reaction: histone H2A-serine (position 1) + ATP = histone H2A-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211948", "l": "CYP3A4 can N-demethylate loperamide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41264", "l": "NAD(+) + prostaglandin A1 => 15-oxo-prostaglandin A1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58812", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}, {"i": "EC:5.1.1.23", "l": "\"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879942", "l": "The receptor is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73558", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69366", "l": "CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine => 6-diazo-5-oxo-L-norleucine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189406", "l": "4 PBGs bind to form HMB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59979", "l": "2-phenylacetate + H(+) <=> CO2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59909", "l": "H2O + hexanal + NADP(+) => 2 H(+) + hexanoate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624951", "l": "TNPO1 binds KIF17 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035185", "l": "NR1H2,3 binds the NR1H3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602484", "l": "Activation of proMMP11 by FURIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10660", "l": "L-seryl-[protein] = D-seryl-[protein]", "d": [], "t": []}, {"i": "EC:5.1.1.16", "l": "\"protein-serine epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163320", "l": "Association of mTERF with the termination sequence (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25463", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sibirene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71818", "l": "3,3',5'-triiodo-L-thyronine(out) <=> 3,3',5'-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102573", "l": "aminodeoxyfutalosine synthase activity", "d": ["Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O = aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.15940764878269", "identifiers": [{"i": "GO:0004536", "l": "DNA nuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391934", "l": "DP2 receptor can bind PGD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102252", "l": "cellulose 1,4-beta-cellobiosidase activity (reducing end)", "d": ["Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051393", "l": "alpha-actinin binding", "d": ["Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174963", "l": "NAT1 acetylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685950", "l": "Endocytosis of protein 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950456", "l": "IL12B dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45459", "l": "H2O + N-dodecanoylethanolamine <=> dodecanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047941", "l": "glucuronolactone reductase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68628", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}, {"i": "EC:4.4.1.40", "l": "\"C-phycoerythrin beta-cysteine-48/59 phycoerythrobilin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41995", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018530", "l": "(R)-6-hydroxynicotine oxidase activity", "d": ["Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64148", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GalNAc-R + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53636", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14725", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46364", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25898", "l": "acetate + CO2 => H(+) + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.30", "l": "\"NAD(+) ADP-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102451", "l": "kaempferide 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine = 3,4'-dimethylkaempferol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002440", "l": "Removal of fibrillar collagen C-propeptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62715", "l": "betaenone C + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381109", "l": "IRE1 binds IRE1 forming dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39922", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60787", "l": "2-oxoglutarate + gibberellin A24 + O2 <=> CO2 + gibberellin A25 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24355", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35597", "l": "2 H(+) + maleylacetate => benzene-1,2,4-triol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42026", "l": "3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH => 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44459", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74885", "l": "GUCYs converts GTP to cGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38103", "l": "L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.146", "l": "\"L-galactonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63272", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72244", "l": "catechol + S-adenosyl-L-methionine => guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202453", "l": "Auto-ubiquitination of TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40040", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate => 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112121", "l": "Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59743", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61458", "l": "(1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+) => 7-chlorotetracycline + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62230", "l": "AH2 + patulin => (E)-ascladiol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411365", "l": "Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36500", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34941", "l": "menaquinol-8 + selenate => H2O + menaquinone-8 + selenite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30224", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide => 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805059", "l": "CK2:FACT phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297354", "l": "Acrosin Cleavage (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24275", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 <=> H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692315", "l": "OX40L binds OX40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689111", "l": "PARK2 autoubiquitinates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38951", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47424", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O = (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70669", "l": "H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein] => a fatty acyl-[ACP] + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30204", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22596", "l": "cephalosporin C + H2O = acetate + deacetylcephalosporin C + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.41", "l": "\"cephalosporin-C deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70102", "l": "H(+) + o-quinone methide + peniphenone D <=> penilactone A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043872", "l": "lysine:cadaverine antiporter activity", "d": ["Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63512", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 = biphenyl-2,2',3-triol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380930", "l": "Phosphorylated AMPK binds AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848370", "l": "IL18 binds IL18R1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22517", "l": "ATP + taurocyamine => ADP + H(+) + N-phosphotaurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20876", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.3", "l": "\"(R)-benzylsuccinyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60442", "l": "acetate + H(+) + methanol => H2O + methyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166869", "l": "TRAF6 binds MEKK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50036", "l": "choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31145", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237129", "l": "Acireductone is created (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35629", "l": "delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP => delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42148", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64412", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23747", "l": "2-oxoglutarate + L-histidinol phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817269", "l": "DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264865", "l": "Caspase-mediated cleavage of Lamin A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211874", "l": "CYP2S1 4-hydroxylates atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36002", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668605", "l": "RAC2:GTP binds NOX2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26500", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32044", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => 2 ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28998", "l": "H(+)(out) + L-threonine(in) <=> H(+)(in) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21205", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol => a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9652264", "l": "ERBB2 binds TKIs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71990", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004447", "l": "iodide peroxidase activity", "d": ["Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862300", "l": "LYZ binds bacterial peptidoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052692", "l": "raffinose alpha-galactosidase activity", "d": ["Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27323", "l": "6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23444", "l": "(S)-lactate + NAD(+) = H(+) + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.1.27", "l": "\"L-lactate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879930", "l": "STAT5 is recruited by JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59777", "l": "D-arabinitol + O2 => D-arabinose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095889", "l": "MMACHC dealkylates RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24146", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48006", "l": "3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O => 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65220", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624014", "l": "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67792", "l": "ribonucleotidyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51186", "l": "H(+) + octadecanoate + sn-glycero-3-phospho-L-serine => 1-octadecanoyl-sn-glycero-3-phosphoserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001512", "l": "dihydronicotinamide riboside quinone reductase activity", "d": ["Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047999", "l": "hyponitrite reductase activity", "d": ["Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = 2 H+ + hyponitrous acid + 2 NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389532", "l": "PP2A binds CTLA4 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39845", "l": "a triacyl-sn-glycerol + CoA => a 1,3-diacyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110311", "l": "POLZ extends translesion synthesis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31190", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16162", "l": "2 Fe(III)-[leghemoglobin] + NADH => 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264458", "l": "Proteasome mediated degradation of COP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008316", "l": "structural constituent of vitelline membrane", "d": ["The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805103", "l": "AURKA phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22456", "l": "creatine + H2O = sarcosine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.3", "l": "\"creatinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38013", "l": "chlorophyllide a + H(+) + phytol => chlorophyll a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449829", "l": "IL11 binds IL11RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12400", "l": "beta-nicotinamide D-ribonucleotide + H2O = NH4(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}, {"i": "EC:3.5.1.42", "l": "\"nicotinamide-nucleotide amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749494", "l": "IKBIP binds IKBKB and CHUK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.857986167591278", "identifiers": [{"i": "GO:0005179", "l": "hormone activity", "d": ["The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12835", "l": "a carboxylate + D-glutamate => an N-acyl-D-glutamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71856", "l": "taurochenodeoxycholate(out) => taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76132", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) => 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70777", "l": "6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite => 6-sulfo-D-quinovose + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612073", "l": "NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75573", "l": "11-O-acetylcyathin A3 + CoA => acetyl-CoA + cyathin A3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191656", "l": "Closure of gap junction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941895", "l": "Formation of CDK4/6:CCND complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12273", "l": "H(+) + L-dopa => CO2 + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2167942", "l": "Collagen type XIII ectodomain shedding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71180", "l": "L-histidine(out) + L-tryptophan(in) => L-histidine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983158", "l": "Trimming of peptides in ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350058", "l": "Formation of CSL NCOR corepressor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59139", "l": "ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38245", "l": "1-O-eicosanyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + eicosan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140232", "l": "intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73445", "l": "CO2 + formaldehyde + H(+) + nevadensin + succinate => 2-oxoglutarate + gardenin B + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42480", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76559", "l": "1-(ergostan-3beta-yl)-L-aspartate + H2O = ergosterol + H(+) + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102655", "l": "1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944225", "l": "Association of procollagen type XVII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41873", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63399", "l": "A + Fe(II)-heme i + H2O <=> AH2 + Fe(II)-hydroxyheme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158357", "l": "factor XIIa binds SERPING1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102093", "l": "acrylate:acyl-coA CoA transferase activity", "d": ["Catalysis of the reaction: acryloyl-CoA + H2O = acrylate + coenzyme A + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004971", "l": "AMPA glutamate receptor activity", "d": ["An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42175", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 <=> (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26299", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O => 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44212", "l": "3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044548", "l": "S100 protein binding", "d": ["Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16628", "l": "acetyl-CoA + hydrogen sulfide <=> CoA + thioacetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11877", "l": "NAD(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68217", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56742", "l": "a globoside GalGb3Cer + H(+) + UDP => a globoside Gb3Cer + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18903", "l": "benzyl alcohol + CO2 + L-leucine => H(+) + H2O + N-benzyloxycarbonyl-L-leucine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63597", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665998", "l": "MKL1 binds SRF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55734", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811427", "l": "COPI vesicle uncoating at the ER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718360", "l": "GNRHR binds GNRHR peptide agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31797", "l": "(+)-caryolan-1-ol => (+)-(E)-beta-caryophyllene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66657", "l": "Cu(2+)(out) + L-ascorbate(in) => Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74734", "l": "Re-integration of insulin receptor into plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66942", "l": "12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B => acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63434", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24895", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine => isopimpinellin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866858", "l": "CFTR F508del is degraded by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619669", "l": "L-PRX dimer binds DRP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69067", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22120", "l": "CoA + GTP + succinate = GDP + phosphate + succinyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.4", "l": "\"succinate--CoA ligase (GDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66756", "l": "ATP + domoate(in) + H2O = ADP + domoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727288", "l": "7a localizes to the ERGIC membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62358", "l": "8-oxo-GMP + H(+) + phosphate => 8-oxo-GDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33243", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69684", "l": "daidzein 7-O-beta-D-glucoside + H2O => beta-D-glucose + daidzein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2317314", "l": "AKT binds PDPK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47234", "l": "(2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358460", "l": "HPE SHH variants don't undergo autoproteolytic cleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805059", "l": "CK2:FACT phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75515", "l": "H2O + N-acetyl-L-cysteine = acetate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296309", "l": "HCAR3 binds HCAR3 ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004677", "l": "DNA-dependent protein kinase activity", "d": ["DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429441", "l": "SYK activation by SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912790", "l": "CBL binds CRK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004815", "l": "aspartate-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52358", "l": "adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate => 3'-phosphoadenylyl sulfate + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72311", "l": "glutathione(in) + taurocholate(out) = glutathione(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029270", "l": "Recruitment of PLCgamma to membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57584", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.162", "l": "\"flavanone 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54598", "l": "2-hydroxyhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10894", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH => (2R,3S)-3-isopropylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16293", "l": "2-isopropylmaleate + H2O = (2S)-2-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42219", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434650", "l": "MATEs mediate extrusion of xenobiotics (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33111", "l": "(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.127", "l": "\"beta-copaene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034277", "l": "ent-cassa-12,15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0016859", "l": "cis-trans isomerase activity", "d": ["Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers."], "t": []}, {"i": "EC:5.2.-.-", "l": "\"Cis-trans-isomerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74862", "l": "dopamine + formaldehyde <=> H2O + norsalsolinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45923", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63601", "l": "H2O + neocasomorphin => L-isoleucine + neocasomorphin-(1-5)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52008", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59976", "l": "2-phenylacetate + H(+) = CO2 + toluene", "d": [], "t": []}, {"i": "EC:4.1.1.119", "l": "\"phenylacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28847", "l": "Li(+)(in) + melibiose(in) = Li(+)(out) + melibiose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57664", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.27", "l": "\"cathepsin S\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944218", "l": "Association of procollagen type VIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72942", "l": "2 Na(+)(out) + propanoate(out) <=> 2 Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13820", "l": "[protein]-disulfide + H2O + phylloquinone <=> 2,3-epoxyphylloquinone + [protein]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53066", "l": "2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70760", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39096", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) => 3-oxodecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70624", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0016901", "l": "oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule."], "t": []}, {"i": "EC:1.1.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67637", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate => dZMP + fumarate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374173", "l": "AGT(34-41) binds to AGTR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75121", "l": "all-trans-13,14-dihydroretinoate + 2 H(+) + NADH => all-trans-13,14-dihydroretinal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790987", "l": "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66775", "l": "ATP + H2O + uroporphyrin I(in) <=> ADP + H(+) + phosphate + uroporphyrin I(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003959", "l": "NADPH dehydrogenase activity", "d": ["Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11450", "l": "H(+) + NADH + pregnan-21-al => NAD(+) + pregnan-21-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28695", "l": "hydrogencarbonate(in) = hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36800", "l": "a ribonucleoside 5'-diphosphate + H2O => a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755303", "l": "26S proteasome degrades HIFalpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218804", "l": "p38 MAPK activation by VEGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32113", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-resveratrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097246", "l": "catechin binding", "d": ["Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54944", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59286", "l": "D-glucose + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156930", "l": "GTP-binding activates eEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71112", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) => L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28307", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026907", "l": "GGT hydrolyses PCTR2 to PCTR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24985", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10609", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] => (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60128", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202604", "l": "Formation of a heteromeric BMP receptor complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102673", "l": "fatty aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde = NADH(2-) + 2 H+ + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29336", "l": "H2O + L-alanyl-L-glutamate => L-alanine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30183", "l": "L-galactonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.414", "l": "\"L-galactonate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870469", "l": "RGGT geranylgeranylates RAB proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52161", "l": "(E)-phenylacetaldehyde oxime => (Z)-phenylacetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20143", "l": "2-aminoprop-2-enoate + an S-alkyl sulfenate => an S-alkyl-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59319", "l": "D-cellobiose + O2 <=> D-cellobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42732", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.170", "l": "\"16S rRNA (guanine(527)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004578", "l": "chitobiosyldiphosphodolichol beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55861", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683488", "l": "ACE2 is glycosylated to glycosylated-ACE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635839", "l": "ULK3:SUFU dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47542", "l": "NADP(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28585", "l": "ATP + dUDP <=> ADP + dUTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013438", "l": "RHOD binds effectors at the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15223", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+) => a CDP-1,2-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430190", "l": "p-SLP-76 binds NCK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912734", "l": "CBL:CRKL binds RAPGEF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.80", "l": "\"acetylajmaline esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46938", "l": "ATP + H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69047", "l": "2-nitrobutanedioate <=> fumarate + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21351", "l": "8 H(+) + 10 malonyl-CoA <=> 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56681", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425861", "l": "Activation of Protein Kinase C novel isoforms (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34251", "l": "1-deoxysphinganine + NADP(+) = 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10446", "l": "(S)-laudanine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59992", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate = (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50130", "l": "17-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66373", "l": "H2O + sn-glycerol 3-phosphate => glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442749", "l": "CaMKK autophosphorylates in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57950", "l": "3-methylcatechol + H2O + NAD(+) => 2-hydroxytoluene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734274", "l": "Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297444", "l": "Binding of cAMP to HCN channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654224", "l": "Activated FGFR3 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47519", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isochenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63612", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761027", "l": "ZEB2 binds SP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66730", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71310", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) <=> chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38159", "l": "(2S,3S)-hydroxyarginine = (2S,3R)-capreomycidine + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.145", "l": "\"capreomycidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46523", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801666", "l": "PLK2 phosphorylates CENPJ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983424", "l": "Budding of COPII coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602458", "l": "Activation of proMMP10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944232", "l": "Association of procollagen type XII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15592", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine <=> 4-hydroxyphenylglyoxylate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424485", "l": "Release of p-PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54115", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + selina-4(15),7(11)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30727", "l": "dATP + pyruvate = dADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.88", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73554", "l": "GDP(out) + UTP(in) <=> GDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37521", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15348", "l": "ATP + L-arginine + L-tyrosine <=> AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36381", "l": "4alpha-methylzymosterol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047830", "l": "D-octopine dehydrogenase activity", "d": ["Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042286", "l": "glutamate-1-semialdehyde 2,1-aminomutase activity", "d": ["Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13886", "l": "H2O + stipitatonate => CO2 + stipitatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43709", "l": "ATP + H(+) + hexadecanoate => diphosphate + hexadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0003727", "l": "single-stranded RNA binding", "d": ["Binding to single-stranded RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40924", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66492", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53790", "l": "allodeoxycholate + beta-muricholoyl-CoA => allodeoxycholoyl-CoA + beta-muricholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086061", "l": "voltage-gated sodium channel activity involved in bundle of His cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44731", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222597", "l": "Loaded mycobactin gets imported (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27748", "l": "CO2 + cysteamine => H(+) + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48882", "l": "a quinol + CO2 => a quinone + CO + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140912", "l": "membrane destabilizing activity", "d": ["Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60217", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814094", "l": "ARL1:GTP binds ARFIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33949", "l": "2'-N-acetylparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69427", "l": "2-hydroxyisobutanoyl-CoA <=> acetone + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190662", "l": "Connexin oligomerization in Trans-Golgi Network (TGN) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68887", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH <=> 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49363", "l": "2',2'-dihydroxy-2-oxospirilloxanthin <=> 2,2'-dioxospirilloxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686663", "l": "Completion of SSA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61055", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60450", "l": "glycine + S-substituted gamma-glutamyl-L-cysteine => an S-substituted glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785607", "l": "FANCM binds FAAP24 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706287", "l": "Active FLT3 binds to ABL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41539", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30182", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070300", "l": "phosphatidic acid binding", "d": ["Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928624", "l": "EPHBs bind EFNBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71788", "l": "2-oxoadipate + O2 => (R)-2-hydroxyglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420688", "l": "GABAB heterodimeric receptor binds GABA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0043404", "l": "corticotropin-releasing hormone receptor activity", "d": ["Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134532", "l": "TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837354", "l": "NUDT8 hydrolyzes CoA-SH to PPANT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44601", "l": "a fatty acid + ATP + H(+) => a fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051506", "l": "ergosterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15187", "l": "CoA + H(+) + N(2)-succinyl-L-arginine => L-arginine + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29671", "l": "Ca(2+)(in) = Ca(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22362", "l": "5-oxo-D-proline + H2O => D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605717", "l": "GM2A binds and mobilizes ligands (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71802", "l": "Ca(2+)(in) + H(+)(out) <=> Ca(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30675", "l": "tetrahymanol = H2O + squalene", "d": [], "t": []}, {"i": "EC:4.2.1.123", "l": "\"tetrahymanol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34514", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102634", "l": "1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity", "d": ["Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 = flaviolin-2-olate + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64602", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35525", "l": "N-ethylsuccinimide + NADP(+) => H(+) + N-ethylmaleimide + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211164", "l": "AKT phosphorylates FOXO1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48892", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20445", "l": "L-arogenate + oxaloacetate = L-aspartate + prephenate", "d": [], "t": []}, {"i": "EC:2.6.1.78", "l": "\"aspartate--prephenate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70899", "l": "histidine => urocanate + NH4+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36311", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15640", "l": "[alginate](n) + GDP-alpha-D-mannuronate <=> [alginate](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52468", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102965", "l": "alcohol-forming long-chain fatty acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13770", "l": "glycerol + NAD(+) => dihydroxyacetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18848", "l": "(R)-glycerate + NAD(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030794", "l": "(S)-coclaurine-N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71473", "l": "L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6) => H2O + substance P", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682983", "l": "ATM phosphorylates WHSC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31010", "l": "(S)-2,3-epoxysqualene <=> beta-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592387", "l": "Fibulin binds elastic fibres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58430", "l": "(E,E)-2,4-hexadienal + H(+) + NADPH => (E,E)-2,4-hexadien-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45544", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24909", "l": "L-tyrosine <=> (E)-4-coumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71050", "l": "Trimerization of the FASL:FAS receptor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26244", "l": "geranylgeranyl diphosphate <=> diphosphate + elisabethatriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005297", "l": "proline:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51762", "l": "a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62789", "l": "2 fonsecin B + H(+) + NADPH + O2 => aurasperone B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008979", "l": "prophage integrase activity", "d": ["Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68264", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63976", "l": "A + dihydropyriculariol = AH2 + pyriculariol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683593", "l": "ATG7:ATG3:LC3 dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39013", "l": "a triacyl-sn-glycerol(out) => a triacyl-sn-glycerol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41535", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40859", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) = (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68633", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70596", "l": "GOT2 dimer deaminates L-Asp (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.39", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811412", "l": "Active ARF recruits coatomer to the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10543", "l": "7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9844955", "l": "CLN3 transports GalCer to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52272", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine = gramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.45786467499596", "identifiers": [{"i": "GO:0019955", "l": "cytokine binding", "d": ["Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220816", "l": "NOTCH2 binds CNTN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24006", "l": "(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761841", "l": "AcK-NFE2L2-dependent SLC7A11 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857686", "l": "FITM1, FITM2 bind TAGs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669874", "l": "Sorafenib-resistant KIT mutants do not bind sorafenib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044198", "l": "zf-TRAF domain binding", "d": ["Binding to a TRAF-type zinc finger domain of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44284", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA = 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62137", "l": "dGMP + GTP => dGDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39062", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37938", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674385", "l": "p-T,Y MAPKs dimerize (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39952", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72798", "l": "bilirubin-bisglucuronoside(out) <=> bilirubin-bisglucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66016", "l": "bromide + H2O2 = H2O + hypobromite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71783", "l": "MDH2 reduces OA to MAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18000", "l": "Co-precorrin-2 + S-adenosyl-L-methionine <=> Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75267", "l": "D-arabinose + NADP(+) = D-arabinono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53841", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380272", "l": "Plk1-mediated phosphorylation of Nlp (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624798", "l": "LBR binds KPNB1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31621", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797090", "l": "CCNK binds CDK12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799431", "l": "TP53 binds HIPK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17643", "l": "agmatine + CO2 => H(+) + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030144", "l": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196929", "l": "FLAD1 phosphorylates FMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33678", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) <=> H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20458", "l": "D-arabinose + NAD(+) => D-arabinono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37057", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate => 3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801195", "l": "STEAP3 binds BNIP3L (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32582", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22893", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) => (6R)-5,10-methenyltetrahydrofolate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754964", "l": "ADA deamidates RBV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35555", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": [], "t": []}, {"i": "EC:1.14.15.13", "l": "\"pulcherriminic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37653", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68635", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23242", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.-", "l": "\"Hydroxylases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20784", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23122", "l": "a dipeptide(in) + ADP + H(+) + phosphate => a dipeptide(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15300", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818682", "l": "MEN1 binds MLL2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41548", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.307", "l": "\"8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)-tetracenomycin-C 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050118", "l": "N-acetyldiaminopimelate deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + acetate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11505", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68553", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37709", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56472", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74028", "l": "L-alanine(in) + L-threonine(out) => L-alanine(out) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804193", "l": "TP53 stimulates PRDM1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654625", "l": "Activated FGFR3 binds SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12097", "l": "H2O + N-benzylformamide => benzylamine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028724", "l": "AMOT proteins bind YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610735", "l": "NUMB binds ITCH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25223", "l": "CO2 + taurine => H(+) + L-cysteate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70874", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) <=> L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940554", "l": "MMP2 cleaves OPTC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20832", "l": "ATP + guanine(out) + H2O = ADP + guanine(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.6", "l": "\"ABC-type guanine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006992", "l": "MECP2 is phosphorylated at S423 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913451", "l": "IL3RB is phosphorylated on Ser-585 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013009", "l": "RHOA binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875568", "l": "RAPGEF1 activates RAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20253", "l": "(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.85", "l": "\"dimethylmaleate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474196", "l": "Collagen type II degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858475", "l": "TNFSF9 binds TNFRSF9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169719", "l": "Secreted CD14 binds LPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77073", "l": "(1R,4R,5S)-acoradiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090488", "l": "polo box domain specific binding", "d": ["Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26017", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate <=> 3-dehydroquinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174119", "l": "Free APC/C phosphorylated by Plk1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74899", "l": "(2E)-2-butenoate + ATP + holo-[ACP] = (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1364044", "l": "PRLR:JAK2 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015018", "l": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29343", "l": "L-aspartate(in) + succinate(out) = L-aspartate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75167", "l": "CTP + NAD(+) = CDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395517", "l": "NADPH transfers electrons to FDXR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53485", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH => 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64932", "l": "dGTP + 2 H2O = dGMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20181", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.19", "l": "\"UDP-glucose--glycoprotein glucose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73525", "l": "TTP(in) + UTP(out) => TTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49805", "l": "2-methylpropan-1-amine + FMNH2 + O2 => FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24951", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62641", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide => [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56076", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019155", "l": "3-(imidazol-5-yl)lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12814", "l": "L-glutamate => D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52188", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695949", "l": "SPHK2 phosphorylates sphingoid (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75530", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 <=> benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.28", "l": "\"S-methyl-5'-thioadenosine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57523", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21611", "l": "isoliquiritigenin + S-adenosyl-L-methionine <=> 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12484", "l": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.5", "l": "\"5'-nucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204813", "l": "Interaction of Tie2 and Grb14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33413", "l": "(S)-malyl alpha-D-glucosaminide + acetate => (S)-malyl N-acetyl-alpha-D-glucosaminide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44586", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20885", "l": "H2O + L-serine + NAD(+) => 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21421", "l": "NADP(+) + prostaglandin I2 => 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16633", "l": "guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA", "d": [], "t": []}, {"i": "EC:2.4.2.64", "l": "\"tRNA-guanosine(34) queuine transglycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40834", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018537", "l": "coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H+ = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41886", "l": "3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP] => dodecanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139918", "l": "Phosphorylation of BIM by JNK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31067", "l": "6-amino-2-oxohexanoate = Delta(1)-piperideine-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784598", "l": "NPPA(124-151) binds NPR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11180", "l": "ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": [], "t": []}, {"i": "EC:6.1.1.22", "l": "\"asparagine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.1", "l": "\"rubredoxin--NAD(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675194", "l": "Activated MAPK phosphorylates RAF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59084", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865994", "l": "GAB1 binds PTPN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63408", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 = 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17897", "l": "A + ethylbenzene + H2O = (S)-1-phenylethanol + AH2", "d": [], "t": []}, {"i": "EC:1.17.99.2", "l": "\"ethylbenzene hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190258", "l": "FGFR2c binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420052", "l": "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeraniol + diphosphate", "d": [], "t": []}, {"i": "EC:3.1.7.5", "l": "\"geranylgeranyl diphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40888", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65455", "l": "ethanol + hexanoyl-CoA <=> CoA + ethyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043911", "l": "D-lysine transaminase activity", "d": ["Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944262", "l": "Association of procollagen type X (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23589", "l": "oxalate + succinyl-CoA => oxalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49094", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31245", "l": "(4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH => H2O + L-4-hydroxyglutamate semialdehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106331", "l": "sialate 4-O-acetylesterase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate."], "t": []}, {"i": "RHEA:25564", "l": "H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428909", "l": "Activated TP receptor binds G-protein  G13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362386", "l": "Glycosylation of Hh (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77282", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17816", "l": "D-altronate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213241", "l": "Formation of nonameric complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73016", "l": "D-leucine(in) => D-leucine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190256", "l": "FGFR1c binds to FGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602147", "l": "Defective CYP2R1 does not 25-hydroxylate vitamin D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019970", "l": "interleukin-11 binding", "d": ["Binding to interleukin-11."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35217", "l": "H(+) + phosphate + XMP => H2O + XDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043522", "l": "leucine zipper domain binding", "d": ["Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902118", "l": "calcidiol binding", "d": ["Binding to calcidiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72524", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205132", "l": "NRAGE activates JNK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23402", "l": "5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+) => 7,8-dihydroxykynurenate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702623", "l": "sorafenib-resistant FLT3 mutants don't bind sorafenib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63842", "l": "[thioredoxin]-disulfide + H2O + tert-butanol => [thioredoxin]-dithiol + tert-butyl hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47955", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O <=> [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050007", "l": "isonocardicin synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H+ + isonocardicin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693598", "l": "ATM phosphorylates NBN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31803", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose = 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": [], "t": []}, {"i": "EC:3.6.1.57", "l": "\"UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57293", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O => a guanosine in RNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089971", "l": "Secretion of collagens (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67421", "l": "a glycerophospholipid + H2O => a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22509", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) => diphosphate + DNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32276", "l": "4-(phosphooxy)-L-threonine + NAD(+) => 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947535", "l": "Cyclisation of GTP to precursor Z (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14792", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951499", "l": "Loading of antigenic peptides on to class I MHC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624956", "l": "PDE6D binds INPP5E (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.25", "l": "\"shikimate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51317", "l": "(9Z)-octadecenoate + glycine => H2O + N-(9Z-octadecenoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29822", "l": "ATP + H2O + L-isoleucine(out) <=> ADP + H(+) + L-isoleucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64774", "l": "2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol => S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682311", "l": "Defective ABCA12 does not transport lipids from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.18", "l": "\"carboxypeptidase T\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22743", "l": "ATP + D-hexose <=> ADP + D-hexose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42259", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69199", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140394", "l": "ABC-type azole transporter activity", "d": ["Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out)."], "t": []}, {"i": "RHEA:33503", "l": "ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44013", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53889", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38602", "l": "NADP(+) + nicotinate <=> nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73381", "l": "(R)-lipoate(in) + 2 Na(+)(in) => (R)-lipoate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36855", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S-substituted L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59109", "l": "chenodeoxycholate + octyl beta-D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708457", "l": "HM13 cleaves HMOX1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21558", "l": "[calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine => [calmodulin]-L-lysine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63029", "l": "(15Z)-tetracosenamide + H2O => (15Z)-tetracosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57533", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191636", "l": "Phosphorylation of Cx43 by c-src (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54113", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + selina-4(15),7(11)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72220", "l": "3 hydrogencarbonate(out) + Na(+)(out) => 3 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607736", "l": "MALT1 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451033", "l": "(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696323", "l": "CNRs bind CNR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16190", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030353", "l": "fibroblast growth factor receptor antagonist activity", "d": ["Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66575", "l": "2-naphthol + 3'-phosphoadenylyl sulfate <=> 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140864", "l": "histone H2AK129 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-129 residue."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73181", "l": "H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether => S-adenosyl-L-methionine + scutellarein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20160", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] <=> an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29574", "l": "H(+)(in) + L-idonate(in) <=> H(+)(out) + L-idonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782820", "l": "USP17 deubiquitinates SUDS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44536", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21529", "l": "[phosphate](n) + H2O => [phosphate](n-1) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45062", "l": "(9Z)-octadecenoate + ethanolamine => H2O + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874209", "l": "CREB3L4 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26507", "l": "(9Z)-octadecenamide + H2O => (9Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40984", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32158", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine <=> adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66612", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA = methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989773", "l": "Expression of CPT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16741", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.22", "l": "\"2-acylglycerol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49285", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP => CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781941", "l": "WNTs are secreted in exosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848930", "l": "PTK6 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748991", "l": "XDH oxidises 6MP to 6TU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24549", "l": "an N(6)-acyl-L-lysine + H2O => a carboxylate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375151", "l": "Interaction of NCAM1 with collagens (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878023", "l": "SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698265", "l": "Enhanced autophagosome formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71751", "l": "2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30568", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate => 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604731", "l": "Autocatalytic activation of MMP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769394", "l": "AKT phosphorylates CBY1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76771", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,3-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026918", "l": "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39820", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60646", "l": "adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+) => 3'-phosphoadenylyl sulfate + androsterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174446", "l": "Removal of remaining Flap from the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391168", "l": "SIRP gamma binds CD47 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20576", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39607", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH = (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13208", "l": "a monosaccharide 1-phosphate + H(+) + UTP <=> a UDP-monosaccharide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47828", "l": "a ganglioside GT1b + H2O = a ganglioside GD1b + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617758", "l": "EP300,CREBBP acetylate FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733960", "l": "Bile salts and acids dissociate from ALB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036136", "l": "kynurenine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57626", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61345", "l": "H2O + L-serine + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31981", "l": "H2O + NADP(+) + trimethylamine N-oxide => NADPH + O2 + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39019", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.95", "l": "\"phosphatidylinositol-3,5-bisphosphate 3-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17789", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.116", "l": "\"3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692749", "l": "CDC14A,B bind MAPK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033984", "l": "indole-3-glycerol-phosphate lyase activity", "d": ["Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.74", "l": "\"methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase [NAD(P)H-oxidizing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75400", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) => 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419645", "l": "Dimerization of LIMK1 by Hsp90 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052772", "l": "brefeldin A esterase activity", "d": ["Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54077", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + stellata-2,6,19-triene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050628", "l": "2-oxopropyl-CoM reductase (carboxylating) activity", "d": ["Catalysis of the reaction: acetoacetate + coenzyme M + NADP+ = 2-oxopropyl-coenzyme M + CO2 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55707", "l": "glycine + hydrogen sulfide + NAD(+) <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10296", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19025", "l": "H2O + L-aspartate + O2 = H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62393", "l": "levoglucosan + NAD(+) => 3-dehydrolevoglucosan + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032500", "l": "muramyl dipeptide binding", "d": ["Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0033765", "l": "steroid dehydrogenase activity, acting on the CH-CH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874162", "l": "ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22831", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688834", "l": "ATXN3 binds VCP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13527", "l": "(1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33769", "l": "a (2E)-enoyl-CoA + H2O => a 3-hydroxy-fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20799", "l": "aldehydo-D-ribose <=> D-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72401", "l": "2-oxoglutarate(in) + estrone 3-sulfate(out) => 2-oxoglutarate(out) + estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42188", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433395", "l": "Dimerization of sSCF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19913", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) = a 3-oxoacyl-[ACP] + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.212", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19762", "l": "FMN-N(5)-oxide + H(+) + NADH => FMN + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36268", "l": "caffeine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12818", "l": "2,3-dihydrobiochanin A + NADP(+) => biochanin A + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734730", "l": "ORC1 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418866", "l": "PITPalpha binds DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48240", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48316", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12688", "l": "2 mycothiol + NADP(+) <=> H(+) + mycothione + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015541", "l": "secondary active cyanate transmembrane transporter activity", "d": ["Enables the transfer of cyanate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43617", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65605", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76605", "l": "10,13-dihydroxyoctadecanoate => (12Z)-10-hydroxyoctadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66684", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018462", "l": "4-(hydroxymethyl)benzenesulfonate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781905", "l": "ZRANB1 binds APC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46637", "l": "5beta-dihydrotestosterone + NADP(+) => H(+) + NADPH + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48703", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33608", "l": "(9Z)-octadecenoate + ATP + CoA => (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944227", "l": "Association of procollagen type XXII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39241", "l": "NADP(+) + triacontanoyl-CoA => (2E)-triacontenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69926", "l": "castasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60615", "l": "1-octanoyl-sn-glycero-3-phosphocholine <=> 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41109", "l": "2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191763", "l": "snRNP:Snurportin complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71299", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) = chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12475", "l": "H2O + N-ethylglycine + O2 <=> ethylamine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48292", "l": "a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051675", "l": "isopullulanase activity", "d": ["Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549304", "l": "OCT3 mediates renal clearance of organic cations (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41924", "l": "(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47140", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44854", "l": "CoA + O-(5Z)-tetradecenoyl-(R)-carnitine => (5Z)-tetradecenoyl-CoA + (R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36113", "l": "O-methyl gibberellin A1 + S-adenosyl-L-homocysteine => gibberellin A1 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41094", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0043515", "l": "kinetochore binding", "d": ["Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69289", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => sulfate + sulforaphane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42426", "l": "(2R,3S)-3-methylmalate => 2-methylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33313", "l": "2 AH2 + H(+) + H2O + N2 => 2 A + hydroxylamine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59051", "l": "D-ornithine + H(+) <=> CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174119", "l": "Free APC/C phosphorylated by Plk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48918", "l": "a ganglioside GD1c + CMP + H(+) => a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13609", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.150", "l": "\"1-phosphatidylinositol-3-phosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31639", "l": "mycinamicin III + S-adenosyl-L-methionine = H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.237", "l": "\"mycinamicin III 3''-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18930", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66316", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O = alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015128", "l": "gluconate transmembrane transporter activity", "d": ["Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.68", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71341", "l": "chloride(in) + L-tyrosine(in) + 2 Na(+)(in) => chloride(out) + L-tyrosine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74691", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73336", "l": "ATP + beta-alanine + tryptamine => AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19687", "l": "CoA + H(+) + N-[(E)-feruloyl]tyramine => (E)-feruloyl-CoA + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030272", "l": "5-formyltetrahydrofolate cyclo-ligase activity", "d": ["Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53362", "l": "H(+) + NADPH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76072", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097257", "l": "leukotriene B4 12-hydroxy dehydrogenase activity", "d": ["Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29280", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide => H2O + menaquinone-8 + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668148", "l": "F8 variant is not sulfonated at Y1699 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40176", "l": "O2 + octanoyl-CoA => (2E)-octenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018500", "l": "trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity", "d": ["Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31178", "l": "(2E)-2-methylpropenoyl-CoA + H2O <=> (S)-3-hydroxyisobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102119", "l": "gibberellin A20 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191402", "l": "Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111264", "l": "Addition of nucleotides between position +11 and +30 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38985", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55873", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) => 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53875", "l": "CTP + D-ribose 5-phosphate + H(+) <=> CDP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388832", "l": "PI3K binds CD28 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51921", "l": "a quinone + AH2 => A + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048273", "l": "mitogen-activated protein kinase p38 binding", "d": ["Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28372", "l": "hydrogencarbonate + phosphoenolpyruvate => oxaloacetate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14986", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008200", "l": "NFE2 binds the beta globin locus control region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615638", "l": "EGR2 and SOX10 bind the MBP gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004417", "l": "hydroxyethylthiazole kinase activity", "d": ["Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655263", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37718", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine <=> 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696960", "l": "USP49 deubiquitinates H2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080101", "l": "phosphatidyl-N-dimethylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015420", "l": "ABC-type vitamin B12 transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044748", "l": "3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59796", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981728", "l": "Factor H binds to membrane-associated C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42627", "l": "(Z)-3-ureidoacrylate + H(+) + H2O <=> (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647660", "l": "GSDME (1-270) binds PIPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30684", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-D-mannosamine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665009", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021050", "l": "HSBP1 oligomer binds ESRs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19660", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202216", "l": "Phosphorylation of SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681987", "l": "LC3 is cleaved by ATG4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57554", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445714", "l": "Aquaporin-3 passively transports water out of cell (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37198", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36614", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045439", "l": "isopenicillin-N epimerase activity", "d": ["Catalysis of the reaction: isopenicillin N = penicillin N."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51720", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18133", "l": "ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.4", "l": "\"sulfate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57819", "l": "dGMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17482", "l": "2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22722", "l": "ADP + H(+) + N(pros)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73168", "l": "CoA(out) + NAD(+)(in) => CoA(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60393", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853890", "l": "VENTX binds the IL6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47009", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951644", "l": "Release of mature NEDD8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833973", "l": "ISGylation of PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141125", "l": "tRNA-queuosine(34) galactosyltransferase activity", "d": ["Catalysis of the reaction: queuosine34 in tRNA + UDP-alpha-D-galactose = H+ + O-5''-beta-D-galactosylqueuosine34 in tRNATyr + UDP. Substrates include tRNA(Tyr) and tRNA(Asp)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10252", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine = L-cysteine + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.65", "l": "\"O-phosphoserine sulfhydrylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008900", "l": "P-type potassium:proton transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31964", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41727", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11713", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74155", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine = formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852324", "l": "GTSE1 binds PLK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29743", "l": "2-phenylethylamine(in) = 2-phenylethylamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619376", "l": "CAMK1 binds calmodulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32341", "l": "(+)-thujan-3-one + H(+) + NADPH => (+)-thujan-3-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045520", "l": "interleukin-24 receptor binding", "d": ["Binding to an interleukin-24 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43096", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.209", "l": "\"23S rRNA (guanine(2535)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.186", "l": "\"glycogenin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656459", "l": "Defective KHK does not phosphorylate beta-D-fructose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10726", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-6-deoxy-alpha-D-talose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37670", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57582", "l": "S-methyl-1-thiol-D-ribulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59392", "l": "acetyl-CoA + L-seryl-[protein] = CoA + O-acetyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.202", "l": "\"multisite-specific tRNA:(cytosine-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47183", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) <=> (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56744", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.73", "l": "\"[protein]-arginine 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954208", "l": "ERBB4s80:ESR1 binds PGR gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176517", "l": "SULTs transfer (SO4)2- group to PREG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10949", "l": "ATP + D-glucosamine => ADP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810643", "l": "EPPIN protein complex binds bacteria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39614", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43209", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine => 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76538", "l": "FAD(in) <=> FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34563", "l": "CDP-alpha-D-abequose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.341", "l": "\"CDP-abequose synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43732", "l": "a triacyl-sn-glycerol + H2O = a 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67961", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine => 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670673", "l": "FIX is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42154", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686088", "l": "CASP3 cleaves GSDMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57247", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP <=> dGTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21432", "l": "(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54995", "l": "3 A + FMN + H2O + L-glutamate + O2 <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30746", "l": "beta-nicotinamide D-riboside + H2O <=> D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45297", "l": "a sphingosylphosphocholine + H2O => a sphingoid base + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33660", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57199", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] <=> glycolate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938887", "l": "PML binds RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76181", "l": "a dipeptide(in) + 2 H(+)(in) => a dipeptide(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70723", "l": "sitosterol(out) = sitosterol(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28408", "l": "H(+) + phosphate + XDP => H2O + XTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10730", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-6-deoxy-alpha-D-talose + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23631", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62585", "l": "ATP + H2O + L-tyrosine(out) => ADP + H(+) + L-tyrosine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48956", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11085", "l": "3-dehydro-L-gulonate + H(+) => CO2 + L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1170539", "l": "Prolactin receptor is internalized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508292", "l": "SYK binds IL2RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63560", "l": "angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine", "d": [], "t": []}, {"i": "EC:3.4.15.1", "l": "\"peptidyl-dipeptidase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698844", "l": "MLKL binds HSP90:CDC37 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11540", "l": "an N-acyl-D-mannosamine + NAD(+) = an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.233", "l": "\"N-acylmannosamine 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73183", "l": "ADP(in) + FAD(out) = ADP(out) + FAD(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392530", "l": "p-S400-Cot phosphorylates NIK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782820", "l": "USP17 deubiquitinates SUDS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222690", "l": "DlaT reactivates AhpD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022870", "l": "MOBP gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210444", "l": "L-Glutamate loading of synaptic vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37384", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19942", "l": "norcoclaurine + S-adenosyl-L-methionine => coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372359", "l": "pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0071791", "l": "chemokine (C-C motif) ligand 5 binding", "d": ["Binding to chemokine (C-C motif) ligand 5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000773", "l": "phosphatidyl-N-methylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38529", "l": "(9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106389", "l": "ecdysteroid 22-kinase activity", "d": ["Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20919", "l": "L-cysteine + sulfite <=> hydrogen sulfide + L-cysteate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31774", "l": "an all-trans-retinyl ester + H2O <=> 11-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14424", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide <=> 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070883", "l": "pre-miRNA binding", "d": ["Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25851", "l": "(1S,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11476", "l": "glycerol 1-phosphate + H2O = glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56816", "l": "a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36634", "l": "D-ribulose 1,5-bisphosphate + O2 <=> (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62517", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GA2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389463", "l": "Proteinase-activated receptors can bind thrombin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22835", "l": "H2O + N-formimidoyl-L-glutamate <=> N-formyl-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37602", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033509", "l": "USP9X binds Ub:PEX5L (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69142", "l": "Recruitment of Dna2 endonuclease (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17613", "l": "NAD(+) + scyllo-inositol = H(+) + NADH + scyllo-inosose", "d": [], "t": []}, {"i": "EC:1.1.1.370", "l": "\"scyllo-inositol 2-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64078", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004486", "l": "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614605", "l": "Persulfide sulfur is dioxygenated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34770", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70964", "l": "D-phenylalanine + H2O + O2 => 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429101", "l": "HMIT co-transports myo-inositol with a proton (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75462", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40802", "l": "2-methylpropanoyl-CoA + H2O <=> 2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67826", "l": "a lipid X + 2 H(+) + UMP => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836702", "l": "PKR inhibitors bind PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60012", "l": "a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429036", "l": "SLC2A9 transports Fru, Glc, urate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781953", "l": "YOD1 binds VCP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684008", "l": "NBN binds KPNA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22222", "l": "diphosphate + ent-kaur-16-ene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14988", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102139", "l": "2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity", "d": ["Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374723", "l": "Nociceptin receptor binds to nociceptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004139", "l": "deoxyribose-phosphate aldolase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805479", "l": "TP53RK phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67585", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432164", "l": "Ca2+ influx into the post-synaptic cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815510", "l": "MIB2 binds CYLD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11404", "l": "UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate", "d": [], "t": []}, {"i": "EC:5.1.3.6", "l": "\"UDP-glucuronate 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30416", "l": "H(+) + 2 NADPH + O2 + octadecanal => formate + H2O + heptadecane + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43252", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68239", "l": "L-glutamine(in) + Na(+)(in) <=> L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53126", "l": "delta-carotene => all-trans-lycopene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.20", "l": "\"alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59210", "l": "diphosphate + octadecanoyl-AMP => ATP + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44757", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34888", "l": "selenate(in) => selenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71783", "l": "MDH2 reduces OA to MAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65776", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67537", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702849", "l": "CALCR binds gepants (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54628", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 = 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013143", "l": "RAC1 GEFs activate RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265940", "l": "Rad51 assembly at the DNA-damage sites on the chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20655", "l": "cucurbitacin B + H(+) + NADH => 23,24-dihydrocucurbitacin B + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.7", "l": "\"3'(2'),5'-bisphosphate nucleotidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202203", "l": "Recruitment of PI3K to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24794", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71849", "l": "LDH tetramer reduces PYR to LACT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371422", "l": "ATP hydrolysis by HSP70 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17419", "l": "ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate => ATP + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21670", "l": "ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in) => ATP + H2O + sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35109", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+) => 3-nitrotyramine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31496", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67350", "l": "apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => apigenin 7-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.80", "l": "\"methylcytosine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56231", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60579", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] <=> Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050363", "l": "tryptophan dehydrogenase activity", "d": ["Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070635", "l": "nicotinamide riboside hydrolase activity", "d": ["Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28224", "l": "3-dehydro-L-gulonate 6-phosphate + ADP + H(+) => 3-dehydro-L-gulonate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18990", "l": "H(+) + L-valine => 2-methylpropan-1-amine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0009922", "l": "fatty acid elongase activity", "d": ["Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857555", "l": "EGFR phosphorylates GPNMB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199298", "l": "AKT phosphorylates CREB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40304", "l": "A + dodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174235", "l": "Association of Emi1 with Cdc20 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16659", "l": "D-ribose + hypoxanthine => H2O + inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047972", "l": "guanidinopropionase activity", "d": ["Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40518", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate <=> (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625913", "l": "Hypochlorous acid (HOCL) reacts with Lys-monochloramine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696947", "l": "USP47 deubiquitinates POLB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791235", "l": "GADD45A binds AURKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614461", "l": "Tetramerization of procollagen VI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47690", "l": "Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH => cis-4-hydroxy-L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47299", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23248", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.129", "l": "\"inositol 4-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74474", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 <=> (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59149", "l": "ATP + CoA + marinolate C => AMP + diphosphate + marinoloyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35126", "l": "H(+)(out) + L-alanyl-D-glutamate(out) <=> H(+)(in) + L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689000", "l": "AADAC deacetylates PHEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70384", "l": "3-oxosphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67008", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.56", "l": "\"mRNA (guanine-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64949", "l": "dCTP + H2O => dCDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62200", "l": "ethanol + 2 Fe(III)-[cytochrome c] = acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102970", "l": "7-deoxyloganetic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate = H+ + 7-deoxyloganate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40025", "l": "diphosphate + syn-copalol => 9alpha-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18354", "l": "ATP + H2O + K(+)(out) + Na(+)(in) => ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635841", "l": "GLI proteins are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549334", "l": "Defective DPAGT1 does not transfer GlcNAc to DOLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828175", "l": "Formation of the NSL complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378952", "l": "Thyrotropin is a heterodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26049", "l": "glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139842", "l": "Binding of Syk tyrosine kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694527", "l": "Loss of SAR1B GTPase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63728", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164520", "l": "Minus strand DNA synthesis resumes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74682", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) <=> UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75653", "l": "12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate => (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58737", "l": "H2O + TTP => 5-methyl-UMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48508", "l": "cholate + NADP(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25886", "l": "H(+) + N(2)-succinyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-succinyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047093", "l": "4-hydroxyquinoline 3-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17602", "l": "ATP + D-ribulose => ADP + D-ribulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035485", "l": "adenine/guanine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/G mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0140784", "l": "metal ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74723", "l": "Endosome acidification (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71025", "l": "L-leucine(out) + L-phenylalanine(in) => L-leucine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45171", "l": "2 (E)-sinapoyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67901", "l": "glutarate + succinyl-CoA => glutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35544", "l": "3-phosphooxypyruvate + H2O => 3-hydroxypyruvate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35337", "l": "3-oxoisoheptadecanoyl-CoA + CO2 + CoA => H(+) + isopentadecanoyl-CoA + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51674", "l": "glycolate + H(+) => glyoxal + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865482", "l": "KMT2A (MLL) binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22913", "l": "L-valine + pyruvate => 3-methyl-2-oxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047186", "l": "N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180885", "l": "Rev multimer-bound HIV mRNA associates with Crm1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62486", "l": "2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016166", "l": "phytoene dehydrogenase activity", "d": ["Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42551", "l": "uridine(746) in 23S rRNA <=> pseudouridine(746) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853792", "l": "RET tyrosine phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20600", "l": "2 L-cysteine + NAD(+) <=> H(+) + L-cystine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24740", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173626", "l": "Activation of C1r (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047282", "l": "dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944457", "l": "MAF1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36155", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine = A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.272", "l": "\"cobalt-factor III methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982792", "l": "Growth hormone receptor binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030156", "l": "benzodiazepine receptor binding", "d": ["Binding to a peripheral benzodiazepine receptor (PBR)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483087", "l": "PI is exchanged with PC by PITPNB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050603", "l": "thiophene-2-carbonyl-CoA monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45614", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine => H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376122", "l": "DSCAM/DSCAML1 homodimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50575", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177942", "l": "EGFR binds EGF ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654511", "l": "FGFRL1 dimer binds FGFs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008821", "l": "crossover junction DNA endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76777", "l": "1,7-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14138", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine => 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089702", "l": "undecaprenyl-phosphate glucose phosphotransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972966", "l": "POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14302", "l": "4-pyridoxolactone + H2O => 4-pyridoxate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76642", "l": "cytosine(out) <=> cytosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928604", "l": "SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59017", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) => CO2 + cycloeucalenone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698043", "l": "FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012209", "l": "Estrogen-responsive KPNA2 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481044", "l": "Surface deployment of platelet alpha granule membrane components (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45885", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852010", "l": "BTNL2 binds activated T cells surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2245218", "l": "CDK1 phosphorylates PHF8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852019", "l": "MET bound PI3K generates PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12904", "l": "D-arginine + H2O <=> D-ornithine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69736", "l": "phenylsuccinate + succinyl-CoA => 2-phenylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72495", "l": "glutarate(in) + prostaglandin E2(out) = glutarate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13364", "l": "CTP + H(+) + sn-glycerol 3-phosphate <=> CDP-glycerol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754191", "l": "LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.33144287441435", "identifiers": [{"i": "GO:0016708", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0016248", "l": "channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47698", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693347", "l": "CRYM reduces P2C to PPCA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.140", "l": "\"alternansucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210444", "l": "L-Glutamate loading of synaptic vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691211", "l": "NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16713", "l": "H2O + S-succinylglutathione = glutathione + H(+) + succinate", "d": [], "t": []}, {"i": "EC:3.1.2.13", "l": "\"S-succinylglutathione hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050183", "l": "phosphatidylcholine 12-monooxygenase activity", "d": ["Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H+ + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332235", "l": "CBL binds TGFBR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15760", "l": "L-homoserine + NAD(+) <=> H(+) + L-aspartate 4-semialdehyde + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37768", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61126", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin => kaempferol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77186", "l": "L-threonine + uridine-5'-aldehyde <=> (5'S,6'R)-C-glycyluridine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016232", "l": "HNK-1 sulfotransferase activity", "d": ["Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)."], "t": []}, {"i": "REACT:R-HSA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004239", "l": "initiator methionyl aminopeptidase activity", "d": ["Catalysis of the release of N-terminal initiator methionine from peptides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317314", "l": "AKT binds PDPK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15577", "l": "H2O + uridine = D-ribose + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4647593", "l": "EP400 binds CDKN1A promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52038", "l": "L-isoleucine + tuberonate => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3076905", "l": "Extracellular BTD hydrolyses BCTN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987039", "l": "JAK1 binds IL20RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76871", "l": "(S)-1-phenylethylamine + H2O + NAD(+) = acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55434", "l": "carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44767", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450466", "l": "AUF1:mRNA complex is destroyed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003842", "l": "1-pyrroline-5-carboxylate dehydrogenase activity", "d": ["H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379865", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67240", "l": "(R)-S-adenosyl-L-methionine + H2O = adenosine + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:3.13.2.3", "l": "\"(R)-S-adenosyl-L-methionine hydrolase (adenosine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15695", "l": "(R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034722", "l": "gamma-glutamyl-peptidase activity", "d": ["Catalysis of the cleavage of a gamma-linked glutamate bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204871", "l": "Interaction of Tie2 and Grb2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41987", "l": "NAD(+) + propan-2-ol <=> acetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705458", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42469", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20185", "l": "a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.40", "l": "\"CMP-N-acylneuraminate phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834807", "l": "ILF3 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14708", "l": "2 CoA + NADP(+) <=> CoA-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22582", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H2O => (S)-4-hydroxy-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390674", "l": "ADRB1 bind ADR,NAd (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39384", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141437", "l": "Formation of the MCC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44860", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797090", "l": "CCNK binds CDK12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40449", "l": "(2S)-pristanoyl-CoA => (2R)-pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419841", "l": "Light stimulates opsin receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11167", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60457", "l": "ATP + UTP => 3',3'-cUAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34796", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912413", "l": "NOTCH2 mRNA translation controlled by miRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11352", "l": "acetate + ATP = acetyl phosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.2.1", "l": "\"acetate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000403", "l": "Y-form DNA binding", "d": ["Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76710", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50414", "l": "H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661157", "l": "USP9X binds Ub-SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29180", "l": "a menaquinol + 2 O2 => a menaquinone + 2 H(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21219", "l": "ATP + D-ribose 5-phosphate <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823959", "l": "SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785607", "l": "FANCM binds FAAP24 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64080", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938108", "l": "SERPINB13 binds cathepsin L (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63373", "l": "an acyl-CoA + L-cysteinyl-[protein] => an S-acyl-L-cysteinyl-[protein] + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15666", "l": "aldehydo-D-glucose + L-lysyl-[protein] => H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1266684", "l": "IL7 binds HGF(495-728) to form PPBSF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35061", "l": "chloramphenicol(out) + H(+)(in) => chloramphenicol(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37449", "l": "H(+) + H2O + tetracenomycin D3 => O2 + tetracenomycin F1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49818", "l": "3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + H2O + hydrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139919", "l": "Translocation of BIM to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18413", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.179", "l": "\"lactosylceramide beta-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21265", "l": "A + glycolate => AH2 + glyoxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33697", "l": "3-oxoeicosasphinganine + H(+) + NADPH => C20 sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48729", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607744", "l": "MALT1 binds BCL10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11455", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149432", "l": "Transport of VPU to Plasma Membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018594", "l": "MECP2 binds LBR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805546", "l": "Keratin type I binds keratin type II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55706", "l": "ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide => glycine + hydrogen sulfide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33746", "l": "an N-acylsphing-4-enine 1-phosphate + H2O <=> an N-acylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31440", "l": "(2E,6E)-farnesyl diphosphate => alpha-longipinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64937", "l": "dGTP + H2O => dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57022", "l": "ADP + apulose 4-phosphate + H(+) => apulose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984733", "l": "Kinesin-3 is a dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709366", "l": "CO translocates from cytosol to mitochondrial inner membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25578", "l": "3 H2O2 + protoporphyrin IX => 3 O2 + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23696", "l": "myo-inositol + O2 = D-glucuronate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.13.99.1", "l": "\"inositol oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855201", "l": "I(1,3,4,6)P4 transports from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002114", "l": "interleukin-33 receptor activity", "d": ["Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388596", "l": "Melanocortin receptors bind melanocortins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244402", "l": "botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14125", "l": "2 raffinose = 1(F)-alpha-D-galactosylraffinose + sucrose", "d": [], "t": []}, {"i": "EC:2.4.1.166", "l": "\"raffinose--raffinose alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004378", "l": "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28404", "l": "ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10076", "l": "H2O + lactose = beta-D-galactose + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.108", "l": "\"lactase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43109", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38944", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382053", "l": "Translocation of PDGF from ER to Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61570", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine => an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647594", "l": "SAHF formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72334", "l": "3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418865", "l": "Recruitment of ABLIM to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046919", "l": "pyruvyltransferase activity", "d": ["Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36537", "l": "CoA + H(+) + N-docosanoylsphinganine => docosanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034535", "l": "1,2-dihydroxy-8-methylnaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031733", "l": "CCR8 chemokine receptor binding", "d": ["Binding to a CCR8 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140956", "l": "histone H3K79 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68611", "l": "Formation of ORC(1-5) complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34591", "l": "Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.289", "l": "\"cobalt-precorrin-7 (C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204850", "l": "Interaction of Tie2 and Dok-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019186", "l": "acyl-CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16951", "l": "H(+) + NADH + scyllo-inosose => myo-inositol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613490", "l": "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61398", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204798", "l": "Interaction of Tie2 and p85 of PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0031821", "l": "G protein-coupled serotonin receptor binding", "d": ["Binding to a metabotropic serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60284", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52069", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20884", "l": "H2O + L-serine + NAD(+) = 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.7", "l": "\"serine 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49892", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162657", "l": "Inactivation of Myt1 kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15192", "l": "2 Fe(III)-[cytochrome c553] + formate <=> CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67642", "l": "ADP + dZDP => ATP + dZMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46275", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0017128", "l": "phospholipid scramblase activity", "d": ["Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60673", "l": "NAD(+) + nerol => H(+) + NADH + neral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28918", "l": "4-aminobutanoate(in) + H(+)(in) <=> 4-aminobutanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32416", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63676", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73577", "l": "CAD hexamer transforms L-Gln to CAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23990", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate => (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25184", "l": "acetyl-CoA + putrescine <=> CoA + H(+) + N-acetylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735439", "l": "Expression of MYOCD in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866321", "l": "VLDL binds APOC1 and APOC4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42278", "l": "(4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => (2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424484", "l": "Phosphorylation of BTK by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67719", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] <=> H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35305", "l": "3-oxoisopentadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisopentadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29344", "l": "L-aspartate(in) + succinate(out) => L-aspartate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40061", "l": "CoA + decanoate + H(+) => decanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442749", "l": "CaMKK autophosphorylates in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50442", "l": "prostaglandin D1 => prostaglandin H1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65516", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O = NH4(+) + pre-mycofactocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038121", "l": "C-C motif chemokine 21 receptor activity", "d": ["Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71849", "l": "LDH tetramer reduces PYR to LACT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22909", "l": "3',5'-cyclic AMP + H(+) + H2O => 3',5'-cyclic IMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37134", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24476", "l": "H2O + maleimide = H(+) + maleamate", "d": [], "t": []}, {"i": "EC:3.5.2.16", "l": "\"maleimide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47160", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) = 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624611", "l": "FOXO1,FOXO3,(FOXO4) bind FBXO32 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433506", "l": "Phosphorylation of APS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16606", "l": "dodecanoyl-CoA + H2O + oxaloacetate => (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66155", "l": "acetyl-CoA + noradrenaline <=> CoA + H(+) + N-acetylnoradrenaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043856", "l": "anti-sigma factor antagonist activity", "d": ["The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77425", "l": "(2S)-2-cyclohexyl-2-hydroxyacetonitrile => cyclohexanecarbaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43631", "l": "L-serine + NAD(+) <=> aminoacetaldehyde + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001862", "l": "collectin binding", "d": ["Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58042", "l": "(9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+) => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903231", "l": "mRNA base-pairing translational repressor activity", "d": ["A translation repressor activity that acts by base-pairing with an mRNA. The binding can result in targeting the mRNA for degradation or interfering with mRNA translation, hence resulting in posttranscriptional gene silencing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168136", "l": "NOTCH3 binds DLL4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31002", "l": "(S)-2,3-epoxysqualene <=> cucurbitadienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51413", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12552", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = (E)-pinosylvin + 4 CO2 + 4 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.146", "l": "\"pinosylvin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042586", "l": "peptide deformylase activity", "d": ["Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21760", "l": "(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA", "d": [], "t": []}, {"i": "EC:5.1.2.3", "l": "\"3-hydroxybutyryl-CoA epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018562", "l": "3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047678", "l": "arginine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25183", "l": "CoA + H(+) + N-acetylputrescine => acetyl-CoA + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37329", "l": "ADP + H(+) + L-methionyl-L-alanine(in) + phosphate => ATP + H2O + L-methionyl-L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70003", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] = cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23889", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine => [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57557", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70692", "l": "ornithine => putrescine + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51442", "l": "(11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243937", "l": "PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56404", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192851", "l": "vRNA Extension (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193964", "l": "CYP21A2 21-hydroxylates PROG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45720", "l": "N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804425", "l": "TP53 binds POU4F2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38737", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53200", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017042", "l": "glycosylceramidase activity", "d": ["Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174202", "l": "Degradation of multiubiquitinated Securin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39335", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28294", "l": "(2E,6E)-farnesyl diphosphate = (-)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.57", "l": "\"(-)-beta-caryophyllene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76997", "l": "NADPH + 2 oxidized [4Fe-4S]-[ferredoxin] => H(+) + NADP(+) + 2 reduced [4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030562", "l": "rRNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68081", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O => a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375131", "l": "Basigin binds CD98 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61700", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] = AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40130", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28748", "l": "NH4(+)(in) => NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13563", "l": "(S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+) => H2O + meso-2,6-diaminoheptanedioate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75891", "l": "Abortive Initiation After Second Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351412", "l": "Association of MRE11 and NBS1 leads to nuclear localization of MRN complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47084", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10953", "l": "(E)-sinapoyl-CoA + hydroxymalonate => (E)-sinapoyltartronate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948623", "l": "miR-20 microRNAs bind CNOT6L mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328145", "l": "Laminin-111 binds collagen type IV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77011", "l": "(2S)-2-amino-3-methylbutan-1-ol + H2O + NAD(+) = 1-hydroxy-3-methylbutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62336", "l": "AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59180", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.60", "l": "\"pApA phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724745", "l": "PLG(20-810) binds aprotinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052884", "l": "all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity", "d": ["Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614933", "l": "ACEIs bind ACE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23706", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate => GTP + 4 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951966", "l": "EP300 acetylates RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3788061", "l": "Fibronectin degradation by ADAM8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692941", "l": "BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43462", "l": "4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA => dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.755473255981116", "identifiers": [{"i": "GO:0050664", "l": "oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule."], "t": []}, {"i": "EC:1.6.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25667", "l": "(2E)-geranyl diphosphate => beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37043", "l": "ATP + H2O + L-alanyl-L-glutamate(out) = ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39709", "l": "a long-chain fatty acyl-CoA(in) => a long-chain fatty acyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850786", "l": "SPINK6 binds KLK12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10648", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 = 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0043022", "l": "ribosome binding", "d": ["Binding to a ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928597", "l": "EPH:EFN dimers tetramerise (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72864", "l": "3',3',3'-cAAG + H2O => G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20661", "l": "D-alanyl-D-alanine + H2O = 2 D-alanine", "d": [], "t": []}, {"i": "EC:3.4.13.22", "l": "\"D-Ala-D-Ala dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58153", "l": "H2O + NAD(+) + phosphonoacetaldehyde => 2 H(+) + NADH + phosphonoacetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848436", "l": "PTK6 phosphorylates CDKN1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694520", "l": "nsp16 binds VHL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388830", "l": "PI3K binds ICOS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10230", "l": "cis-aconitate + H2O => citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76996", "l": "H(+) + NADP(+) + 2 reduced [4Fe-4S]-[ferredoxin] => NADPH + 2 oxidized [4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166726", "l": "Activation of MASPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72205", "l": "2 chloride(in) + hydrogencarbonate(out) => 2 chloride(out) + hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55334", "l": "a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 3'-hydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76234", "l": "2-oxoglutarate(in) <=> 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45208", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] = Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}, {"i": "EC:2.1.1.246", "l": "\"[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56563", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21775", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O <=> NH4(+) + uridine(6666) in apoB mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10063", "l": "acetyl-CoA + D-tryptophan <=> CoA + H(+) + N-acetyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48975", "l": "ATP + H2O + phosphite(out) <=> ADP + H(+) + phosphate + phosphite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0042162", "l": "telomeric DNA binding", "d": ["Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210935", "l": "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52009", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052876", "l": "methylamine dehydrogenase (amicyanin) activity", "d": ["Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52508", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68701", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41172", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O => 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625421", "l": "The anterograde IFT train dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944229", "l": "Association of procollagen type IX (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44641", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP => a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54333", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13731", "l": "AMP + H(+) + riboflavin cyclic-4',5'-phosphate => FAD", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44347", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67422", "l": "a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "74.58909006025462", "identifiers": [{"i": "GO:0003899", "l": "DNA-directed 5'-3' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66079", "l": "2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52966", "l": "H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429157", "l": "ABCC4 accumulation of dense granule contents (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080042", "l": "ADP-glucose pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375141", "l": "Neogenin:Netrin-3 binds CDO complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983158", "l": "Trimming of peptides in ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675947", "l": "TNFSF18 binds TNFRSF18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018463", "l": "6-hydroxyhexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + H+ + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53443", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938022", "l": "RUNX1:CBFB binds the NR4A3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29236", "l": "a menaquinone + H(+) + NADH => a menaquinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785594", "l": "FANCD2 binds FANCI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213466", "l": "RIPK3 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624954", "l": "INPP5E translocates to the primary cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52336", "l": "a long-chain fatty acid + ATP + H(+) = a long-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840564", "l": "OMA1 hydrolyzes YME1L1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74907", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] = (2E)-butenoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71106", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) <=> L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000433", "l": "SUMOylation of PML with SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15325", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.15", "l": "\"glycerol-3-phosphate 1-O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16091", "l": "ethanolamine + phosphate => H2O + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209336", "l": "Activated HOP is autophosphorylated and/or transphosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62656", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate = 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44941", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30286", "l": "(-)-trans-permethrin + H2O <=> (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140995", "l": "histone H2A kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728664", "l": "GLP1R binds GLP1R agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610954", "l": "HCMV Final Envelopment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18951", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949580", "l": "F1Fo ATP synthase dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618328", "l": "ATAT acetylates microtubules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73865", "l": "dopamine(in) => dopamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62817", "l": "4 monapinone E + O2 => 2 dinapinone E + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12438", "l": "CoA + H(+) + N-caffeoylputrescine => (E)-caffeoyl-CoA + putrescine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37868", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670114", "l": "Histone H3.3 deposition at telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14317", "l": "morphine + NAD(+) = H(+) + morphinone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44105", "l": "decanal + H2O + NAD(+) => decanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034010", "l": "sulfolactate sulfo-lyase activity", "d": ["Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63382", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30927", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:3.2.1.172", "l": "\"unsaturated rhamnogalacturonyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54835", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65970", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59164", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37646", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58280", "l": "4 ATP = cyclic tetraadenylate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60667", "l": "H2O + NADPH <=> NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222341", "l": "H2O2 gets scavenged by unsaturated lipid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029460", "l": "PAK1 phosphorylates LIMK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205306", "l": "Interaction of SHP1 and KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28722", "l": "adenine(in) + H(+)(in) <=> adenine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193665", "l": "MYD88 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63205", "l": "H2O + octadecanoyl-[ACP] => H(+) + holo-[ACP] + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70182", "l": "2 D-maltotetraose <=> alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050438", "l": "2-ethylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64474", "l": "(2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16396", "l": "H2O + juvenile hormone II <=> H(+) + juvenile hormone II carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8957241", "l": "TP73 tetramer translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140816", "l": "NAD+-histone H2BS6 serine ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33261", "l": "N-formimidoylglycine + NH4(+) => 4-aminoimidazole + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34493", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP => H2O + UDP-N,N'-diacetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70189", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035731", "l": "dinitrosyl-iron complex binding", "d": ["Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912385", "l": "Phosphorylated NICD1 binds FBXW7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33047", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.10", "l": "\"(+)-camphor 6-endo-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10831", "l": "anthranilate + ATP + CoA <=> AMP + anthraniloyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655440", "l": "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28300", "l": "(E)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004644", "l": "phosphoribosylglycinamide formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52565", "l": "2-dehydro-L-erythronate => 3-dehydro-L-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198621", "l": "AKT phosphorylates caspase-9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34703", "l": "(2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.137", "l": "\"(E)-2-epi-beta-caryophyllene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43011", "l": "D-serine <=> 2-aminoprop-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63588", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53319", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42208", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 = a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.237", "l": "\"aliphatic glucosinolate S-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047957", "l": "4'-methoxyisoflavone 2'-hydroxylase activity", "d": ["Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32408", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050128", "l": "N-feruloylglycine deacylase activity", "d": ["Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14805", "l": "ATP + D-allose = ADP + D-allose 6-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.55", "l": "\"allose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784735", "l": "PCSK9:LDLR bind to Clathrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38670", "l": "sphing-4-enine 1-phosphate(in) <=> sphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10037", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 => H2O2 + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40098", "l": "26-oxohexacosanoate + H2O + NAD(+) <=> 2 H(+) + hexacosanedioate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.110", "l": "\"aldos-2-ulose dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006332", "l": "JAK2 transphosphorylates and is activated in response to Erythropoietin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102556", "l": "dammarenediol 12-hydroxylase activity", "d": ["Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 = (20S)-protopanaxadiol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032407", "l": "MutSalpha complex binding", "d": ["Binding to a MutSalpha mismatch repair complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20454", "l": "scopoletin + UDP-alpha-D-glucose => H(+) + scopolin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37574", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030746", "l": "isoflavone 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75625", "l": "14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449818", "l": "IL13 binds IL13RA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11482", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 3-hydroxybenzoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75600", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => ectocarpin A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40994", "l": "(E)-4-coumaroyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51525", "l": "(S)-corytuberine + S-adenosyl-L-methionine => magnoflorine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38801", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140399", "l": "aflatoxin B synthase activity", "d": ["Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 = aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048270", "l": "methionine adenosyltransferase regulator activity", "d": ["Binds to and modulates the activity of methionine adenosyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48050", "l": "a ganglioside GM2 (d18:1(4E)) + D-galactose => a ganglioside GM1 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74599", "l": "AMP(out) + UDP-alpha-D-galactose(in) = AMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45262", "l": "tetracosanoate(in) => tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72671", "l": "eIF5B:GTP is hydrolyzed and released (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222346", "l": "AhpC reduces H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11976", "l": "anhydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.38", "l": "\"anhydrotetracycline 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30303", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.95", "l": "\"germacrene A hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004411", "l": "homogentisate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63759", "l": "flavokermesate + UDP-alpha-D-glucose <=> flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10721", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33530", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol <=> CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080081", "l": "4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45080", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine = ADP + dapdiamide E + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25036", "l": "all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218811", "l": "DOCK180:ELMO binds CRK (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626817", "l": "PKC phosphorylates NCF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19482", "l": "acetyl-CoA + succinyl-CoA => 3-oxoadipyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53835", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 <=> a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32060", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O => (R)-glycerate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194025", "l": "11-deoxycortisol translocates to the mitochondrion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53384", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211272", "l": "FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205238", "l": "SHP2 interacts with p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69673", "l": "(2S)-naringenin + beta-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44970", "l": "NADP(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59779", "l": "D-arabinitol + O2 <=> D-arabinose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733292", "l": "AMY1-3 bind pramlintide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35353", "l": "(2E)-octadecenoyl-CoA + H(+) + NADPH => NADP(+) + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170986", "l": "Ral-GDS binds to Ras-GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61912", "l": "ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607002", "l": "Activated protein C cleaves factor VIIIa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004371", "l": "glycerone kinase activity", "d": ["Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.104", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034939", "l": "5-hydroxypyrrole-2-carboxylate tautomerase activity", "d": ["Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61044", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864569", "l": "WWOX binds TFAP2C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52855", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69882", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692867", "l": "HRH3 binds pitosilant (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73423", "l": "L-asparagine(out) = L-asparagine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247840", "l": "WLS binds WNT ligands in the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58458", "l": "(R)-glycerate + D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64312", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin = dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59440", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH = (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381109", "l": "IRE1 binds IRE1 forming dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48428", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043185", "l": "vascular endothelial growth factor receptor 3 binding", "d": ["Binding to a vascular endothelial growth factor receptor 3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854222", "l": "TBC1D3 associates with RAB5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.56", "l": "\"gamma-humulene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71064", "l": "L-arginine(in) + L-histidine(out) => L-arginine(out) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106379", "l": "8-oxo-(d)RTP hydrolase activity", "d": ["Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+."], "t": []}, {"i": "REACT:R-HSA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36748", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694583", "l": "ABHD4 hydrolyses NAPE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0050840", "l": "extracellular matrix binding", "d": ["Binding to a component of the extracellular matrix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33419", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.38", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.52481937437345", "identifiers": [{"i": "GO:0016741", "l": "transferase activity, transferring one-carbon groups", "d": ["Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.1.-.-", "l": "\"Transferring one-carbon groups\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40372", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47927", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate <=> (2S)-3-sulfolactaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31048", "l": "(S)-2-methyl-3-oxopropanoate + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27461", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": [], "t": []}, {"i": "EC:2.7.7.71", "l": "\"D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003881", "l": "CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011346", "l": "MSI1 binds ROBO3.1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75665", "l": "10,11-epoxy-12-hydroxy-(14Z)-eicosenoate => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19016", "l": "dTTP + H2O <=> dTDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395320", "l": "Latent TGF-beta-1 binds integrins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43898", "l": "3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13832", "l": "GDP-alpha-D-rhamnose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52102", "l": "(9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018785", "l": "RHOBTB2 binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641111", "l": "Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58968", "l": "1-naphthaldehyde + H2O + O2 = 1-naphthoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036467", "l": "5-hydroxy-L-tryptophan decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin."], "t": []}, {"i": "RHEA:18533", "l": "5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019211", "l": "phosphatase activator activity", "d": ["Binds to and increases the activity of a phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0003916", "l": "DNA topoisomerase activity", "d": ["Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031865", "l": "EP2 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP2 subtype prostaglandin E2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71032", "l": "L-cysteine(in) + L-phenylalanine(out) => L-cysteine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102828", "l": "stachyose galactinol:verbascose galactosyltransferase activity", "d": ["Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol = verbascose + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061542", "l": "3-demethylubiquinol-n 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53709", "l": "(2E)-decenoyl-CoA + NADP(+) => (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18577", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.302", "l": "\"3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445448", "l": "HHIP binds Hedgehog (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69256", "l": "H2O + progoitrin = (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357472", "l": "PAK1-3 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56039", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74920", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] => a (2E)-enoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47705", "l": "H(+) + iso-precytochalasin + NADPH + O2 => cytochalasin Z16 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64592", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419645", "l": "Dimerization of LIMK1 by Hsp90 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990932", "l": "5.8S rRNA binding", "d": ["Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41229", "l": "4-hydroxyphenylglyoxylate + H2O2 => (S)-4-hydroxymandelate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10701", "l": "H2O + limonene 1,2-epoxide => limonene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166041", "l": "Transfer of LPS onto TLR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70656", "l": "H(+)(in) + sarcosine(in) => H(+)(out) + sarcosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.19", "l": "\"taxifolin 8-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30457", "l": "(-)-geosmin => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614605", "l": "Persulfide sulfur is dioxygenated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28641", "l": "(-)-gamma-cadinene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66323", "l": "2',3'-cGAMP(out) <=> 2',3'-cGAMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033796", "l": "sulfur reductase activity", "d": ["Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877308", "l": "Dephosphorylation of JAKs by PTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67812", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11340", "l": "5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.75", "l": "\"5-guanidino-2-oxopentanoate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102615", "l": "ent-cassadiene-C2-hydroxylase activity", "d": ["Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ = 2alpha-hydroxy-ent-cassadiene + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72193", "l": "(16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73355", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine = carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46818", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226979", "l": "ADD1:ADD2 binds DMTN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43162", "l": "H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine => adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48575", "l": "3,5-dichlorocatechol + O2 <=> (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030733", "l": "fatty acid O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395764", "l": "atREs binds to nascent CM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654514", "l": "KAL1 binds FGFR1c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944263", "l": "Association of procollagen type II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67408", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296301", "l": "CCRL2 binds CCL19 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66283", "l": "solanidine + UDP-alpha-D-glucose <=> H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58314", "l": "25-substituted-cholesterol + D-glucose => 25-substituted-cholesteryl beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424254", "l": "LDLR transports extracellular CR:atREs to cytosol  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209792", "l": "N-acetylation of serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102471", "l": "2-hydroxynaringenin-6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin = isovitexin-7-olate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73364", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine => beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68286", "l": "CoA + O-hexanoyl-L-seryl-[protein] => hexanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802919", "l": "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354060", "l": "Translocation of RIAM to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64231", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59644", "l": "D-xylobiono-1,5-lactone + H2O = D-xylobionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45355", "l": "9,10-epoxyoctadecanoate + H2O <=> 9,10-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32920", "l": "H2O + methyl (indol-3-yl)acetate => (indol-3-yl)acetate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24217", "l": "(2E,6E)-farnesal + H2O + NAD(+) => (2E,6E)-farnesoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52093", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77093", "l": "AMP + diphosphate + H(+) + isochorismoyl-L-glutamate => ATP + isochorismate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64387", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine <=> alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047247", "l": "luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044547", "l": "DNA topoisomerase binding", "d": ["Binding to a DNA topoisomerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44846", "l": "CoA + O-eicosanoyl-(R)-carnitine => (R)-carnitine + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388831", "l": "Phosphorylation of CD28 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14055", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate => D-arabinose 5-phosphate + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019768", "l": "high-affinity IgE receptor activity", "d": ["Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62786", "l": "bifonsecin B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63291", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939204", "l": "ESTG binds ESR1:chaperone complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316347", "l": "RAB4A:GTP binds KIF3 and activates KIF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71942", "l": "2-oxoglutarate(out) + 3 Na(+)(out) <=> 2-oxoglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51269", "l": "norbelladine + S-adenosyl-L-methionine => 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54560", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP = a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781905", "l": "ZRANB1 binds APC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40648", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203774", "l": "Interaction of Csk with PAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64704", "l": "diphenylmethanol + NAD(+) = benzophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015612", "l": "ABC-type L-arabinose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32640", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033933", "l": "branched-dextran exo-1,2-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32788", "l": "ATP + H2O + L-ectoine(out) => ADP + H(+) + L-ectoine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49503", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31676", "l": "NADP(+) + raucaffrinoline => H(+) + NADPH + perakine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44998", "l": "CoA + O-3-oxobutanoyl-(R)-carnitine => (R)-carnitine + acetoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665416", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035034", "l": "histone acetyltransferase regulator activity", "d": ["Binds to and modulates the activity of histone acetyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14034", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31468", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-glucosyl) crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019002", "l": "GMP binding", "d": ["Binding to GMP, guanosine monophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19134", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine => 3,5,3'-triiodothyropyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13857", "l": "a dolichyl beta-D-glucosyl phosphate + H2O = a dolichyl phosphate + D-glucose + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.48", "l": "\"dolichylphosphate-glucose phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61511", "l": "peonidin + UDP-alpha-D-glucose <=> peonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102004", "l": "2-octaprenyl-6-hydroxyphenol methylase activity", "d": ["Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706336", "l": "Active FLT3 binds to SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202702", "l": "CD177 binds PECAM-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67488", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000405", "l": "bubble DNA binding", "d": ["Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987120", "l": "JAK1 binds IFNLR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41801", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358789", "l": "Self-ubiquitination of RNF41 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177937", "l": "Phosphorylation of EGFR by SRC kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37063", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46758", "l": "a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61657", "l": "(2E,6E)-farnesol + ATP => (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694409", "l": "Nucleotide exchange on RAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35041", "l": "spermidine(out) => spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32491", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.113", "l": "\"alpha-humulene 10-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004788", "l": "thiamine diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709179", "l": "DPP4 binds DPP4 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11116", "l": "acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70215", "l": "cortisol + H(+) + NADPH = 20beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56475", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36429", "l": "diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19832", "l": "a primary alcohol + O2 <=> an aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50137", "l": "ethyl (9Z)-octadecenoate + H2O => (9Z)-octadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55072", "l": "2-oxobutanoate + H(+) = CO2 + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015390", "l": "purine-specific nucleoside:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0061578", "l": "K63-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19704", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose <=> a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12375", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O <=> 4-oxohex-2-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18689", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.32", "l": "\"phospholipase A1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67046", "l": "AH2 + chermesin D => A + asnovolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209960", "l": "Diiodinated tyrosine can be deiodinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45441", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69574", "l": "2'-deoxyinosine + IMP => dIMP + inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71326", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) <=> chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.60", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015210", "l": "uracil transmembrane transporter activity", "d": ["Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070338", "l": "5'-flap-structured DNA binding", "d": ["Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840401", "l": "DELE1(143-515) is released into the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51777", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate => deoxycohumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173705", "l": "C5b binds C6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69053", "l": "RFC binding displaces Pol Alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58033", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18440", "l": "4-CDP-2-C-methyl-D-erythritol + ATP <=> 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938930", "l": "RUNX1 binds ELF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610723", "l": "GLI proteins bind SUFU (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090711", "l": "FMN hydrolase activity", "d": ["Catalysis of the reaction: FMN + H2O = riboflavin + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75147", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-cyatha-3,12-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.206", "l": "\"(-)-cyatha-3,12-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944232", "l": "Association of procollagen type XII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73395", "l": "L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53945", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) => (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047163", "l": "3,4-dichloroaniline N-malonyltransferase activity", "d": ["Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26537", "l": "3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19069", "l": "(R)-S-lactoylglutathione = glutathione + methylglyoxal", "d": [], "t": []}, {"i": "EC:4.4.1.5", "l": "\"lactoylglutathione lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12928", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198295", "l": "TRKA phosphorylates IRS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28806", "l": "H2O + L-ascorbate 6-phosphate <=> 3-dehydro-L-gulonate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29192", "l": "L-aspartate + menaquinone-8 => iminosuccinate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74836", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) => UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68273", "l": "a fatty acyl-CoA + L-seryl-[protein] => CoA + O-fatty acyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13334", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381644", "l": "ER calcium channels open in response to activated PKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174446", "l": "Removal of remaining Flap from the C-strand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396029", "l": "Latent TGF-beta-3 binds integrins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002401", "l": "Association of procollagen type XVIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33412", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O => (S)-malyl alpha-D-glucosaminide + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58444", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44927", "l": "2-oxoadipate + acetyl-CoA + H2O <=> (R)-dihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483219", "l": "PC is exchanged with PI by PITPNB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45127", "l": "acarbose + ATP <=> acarbose 7(IV)-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373342", "l": "CX3CR1 binds CX3CL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75486", "l": "estrone 3-sulfate(out) + n H(+)(out) <=> estrone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53806", "l": "allodeoxycholate + ursodeoxycholoyl-CoA => allodeoxycholoyl-CoA + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028724", "l": "AMOT proteins bind YAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25509", "l": "(2E)-geranyl diphosphate => (1S,5S)-sabinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46710", "l": "AMP + H(+) + salicyl-[non-ribosomal peptide synthase] => 2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56392", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.2", "l": "\"hydrogen dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70036", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37790", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399711", "l": "Activation of Ca impermeable AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37687", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050269", "l": "coniferyl-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956568", "l": "RUNX1 binds the core TAL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873946", "l": "OTUD3 deubiquitinates PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73093", "l": "AMP(in) + FMN(out) => AMP(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18148", "l": "ATP + beta-D-fructose <=> ADP + beta-D-fructose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24977", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416358", "l": "G alpha (q) inhibits PI3K alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038177", "l": "death receptor agonist activity", "d": ["Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28135", "l": "(2S)-hesperidin + H2O => (2S)-hesperetin + rutinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74575", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] = N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430183", "l": "NCK binds PAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32338", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) <=> (1S,4R)-fenchone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57901", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 => adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64960", "l": "dTDP + H2O = dTMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429714", "l": "CSNK1G2 phosphorylates p-CERT1-2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23269", "l": "guanidinoacetate + H2O => glycine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0019187", "l": "beta-1,4-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709360", "l": "H2O2 reduces MetHb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74137", "l": "petunidin 3-O-beta-D-galactoside + UDP => petunidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0016907", "l": "G protein-coupled acetylcholine receptor activity", "d": ["Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690461", "l": "FKBP1A binds tacrolimus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45278", "l": "12-hydroxy-(9E)-octadecenoate + phosphate => 12-phosphooxy-(9E)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46334", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33967", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.91", "l": "\"2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69652", "l": "cumene hydroperoxide + 2 glutathione => 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38794", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202726", "l": "F11R dimerises (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58648", "l": "rifamycin SV hemiaminal = H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21005", "l": "(R)-pantolactone + A => 2-dehydropantolactone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72102", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) <=> Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11949", "l": "4-hydroxybenzoyl-CoA + H2O => 4-hydroxybenzoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64682", "l": "CoA + ethyl benzoate => benzoyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67872", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68611", "l": "H(+) + isatin + NADPH <=> 3-hydroxyindolin-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52001", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76775", "l": "decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,7-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.43", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41206", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611721", "l": "β1-agonists bind ADRB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690023", "l": "NUBPL binds 4Fe-4S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15039", "l": "H(+) + N-methylputrescine + S-adenosyl-L-homocysteine => putrescine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23047", "l": "H(+) + N,N-dihydroxy-L-tyrosine <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57994", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside C-K + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51581", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) => a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48083", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] <=> ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932037", "l": "RUNX1 and ESR1 bind the KCTD6 gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21929", "l": "3-dehydro-L-gulonate + NADP(+) => 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42152", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10591", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH <=> 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159250", "l": "ATF7IP binds SETDB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168640", "l": "Ubiquitinated IkB is degraded (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73044", "l": "creatine(in) => creatine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296309", "l": "HCAR3 binds HCAR3 ligands (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876472", "l": "NPC2 binds CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37888", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide => H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0009884", "l": "cytokinin receptor activity", "d": ["Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44157", "l": "1D-myo-inositol 5-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655315", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74984", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] => (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64854", "l": "CoA + octyl benzoate => benzoyl-CoA + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71892", "l": "dGMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56829", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide => 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60869", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928645", "l": "EPHB:NMDAR binds TIAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008741", "l": "ribulokinase activity", "d": ["Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55122", "l": "(3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+) => 4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77589", "l": "1-dodecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41409", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50655", "l": "2-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20047", "l": "2 H(+) + malonate + NADH => 3-oxopropanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201521", "l": "ALK autophosphorylation  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617941", "l": "Expression of superoxide dismutase 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35064", "l": "H2O + pyrazinamide => NH4(+) + pyrazine-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45592", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607747", "l": "TRAF6 binds MALT1 oligomers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77447", "l": "4-methoxybenzaldehyde + hydrogen cyanide = (2S)-2-hydroxy-2-(4-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41530", "l": "NAD(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21980", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}, {"i": "EC:2.8.2.8", "l": "\"[heparan sulfate]-glucosamine N-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098919", "l": "structural constituent of postsynaptic density", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic density."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11579", "l": "ATP + thiamine <=> AMP + H(+) + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928641", "l": "PAK binds RAC and bPIX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43459", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28282", "l": "(S)-beta-bisabolene = (S)-beta-macrocarpene", "d": [], "t": []}, {"i": "EC:5.5.1.17", "l": "\"(S)-beta-macrocarpene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75490", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) <=> dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690873", "l": "ACO1 binds 4Fe-4S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52573", "l": "butanoyl-CoA + NAD(+) => (2E)-butenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036081", "l": "extracellular ammonia-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63315", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031861", "l": "prolactin-releasing peptide receptor binding", "d": ["Binding to a prolactin-releasing peptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60722", "l": "(E)-hept-2-enoate + 2 H(+) + NADPH => (E)-hept-2-enal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55111", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606162", "l": "Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432378", "l": "Nuclear JET binds CRY, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110219", "l": "Cleavage of thymine by TDG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14381", "l": "4-guanidinobutanal + H2O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.54", "l": "\"gamma-guanidinobutyraldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37983", "l": "gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5220959", "l": "TDG excises 5-formylcytosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120147", "l": "formylglycine-generating oxidase activity", "d": ["Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102439", "l": "3',4',5'-trimethylmyricetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73494", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) <=> Co(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55296", "l": "13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10031", "l": "D-glutamate + H2O + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667563", "l": "AVPR2 bind desmopressin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13586", "l": "ATP + butanoate => ADP + butanoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15258", "l": "D-threonine => acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65566", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine => (9Z)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640862", "l": "Tankyrase binds AXIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64319", "l": "2 dihydrogeodin + 2 H(+) + O2 <=> 2 (+)-geodin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34643", "l": "2 S-adenosyl-L-methionine + squalene = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.262", "l": "\"squalene methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17812", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine <=> Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35663", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39313", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21661", "l": "benzaldehyde + H2O + NADP(+) => benzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696131", "l": "AOC1 deaminates Hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9680443", "l": "ROCK1,2 bind ROCKi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55317", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) => 4 H(+) + 3 NADH + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13851", "l": "D-ribulose => D-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70240", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69158", "l": "acrolein + N-(4-aminobutyl)-3-aminopropanal => spermine dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33977", "l": "D-glucose + DIMBOA => DIMBOA beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68678", "l": "adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+) => 3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12411", "l": "L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74994", "l": "deoxyerythrostominone(in) <=> deoxyerythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453358", "l": "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106364", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity", "d": ["4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]."], "t": []}, {"i": "RHEA:20361", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912627", "l": "CBL ubiquitinates PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.419", "l": "\"nepetalactol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205136", "l": "GTP-bound RAC contributes to JNK activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54402", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11485", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) => a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26190", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP => 1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.49", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209738", "l": "VD3 binds GC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15419", "l": "CO2 + L-tyrosine + NADPH => L-arogenate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59134", "l": "AMP + diphosphate + H(+) + staphyloferrin B => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002162", "l": "dystroglycan binding", "d": ["Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69068", "l": "RFC dissociates after sliding clamp formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21539", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39176", "l": "(3R)-hydroxyeicosanoyl-CoA => (2E)-eicosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004461", "l": "lactose synthase activity", "d": ["Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981657", "l": "IL34 dimer binds PTPRZ1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37529", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177942", "l": "EGFR binds EGF ligand (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13657", "l": "acetyl-[citrate lyase ACP] + H2O = acetate + H(+) + holo-[citrate lyase ACP]", "d": [], "t": []}, {"i": "EC:3.1.2.16", "l": "\"citrate-lyase deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029454", "l": "Autophosphorylation of PAK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64106", "l": "1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein] => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507719", "l": "p62:MEKK3 binds to TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77404", "l": "2-methylpropanal + hydrogen cyanide => (2S)-2-hydroxy-3-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73918", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA <=> 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65428", "l": "deamido-NAD(+)(in) + NAD(+)(out) = deamido-NAD(+)(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54368", "l": "acetaldehyde + H(+) + pyruvate = acetoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419003", "l": "Interaction of Nectins with Afadin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47049", "l": "a quinone + shikimate => 3-dehydroshikimate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49653", "l": "H(+) + NADH + O2 + protoviolaceinate => H2O + NAD(+) + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29393", "l": "diphosphate + GMP + H(+) => GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62688", "l": "4 norrubrofusarin + O2 = 2 H2O + 2 ustilaginoidin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62004", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57925", "l": "H2O + mutildienyl diphosphate => diphosphate + premutilin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0005549", "l": "odorant binding", "d": ["Binding to an odorant, any substance capable of stimulating the sense of smell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706336", "l": "Active FLT3 binds to SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21778", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33025", "l": "CO2 + D-ribulose 5-phosphate + NADH => 6-phospho-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37694", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53627", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + tsukubadiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53546", "l": "7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983194", "l": "Kinesin-1 is a heterotetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45019", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine <=> L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71035", "l": "L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392133", "l": "G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46948", "l": "GTP + S-adenosyl-L-methionine = N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51550", "l": "(S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine => (S)-tetrahydropapaverine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20958", "l": "AMP + diphosphate + phenylacetyl-CoA => 2-phenylacetate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030697", "l": "tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + uridine54 in tRNA = 5-methyluridine54 in tRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11887", "l": "3'-phosphoadenylyl sulfate + cortisol <=> adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35842", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> a cardiolipin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70804", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27963", "l": "myo-inositol + pyrroloquinoline quinone => H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400434", "l": "FFAR1 binds fatty acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247843", "l": "secretion of WNT ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.47", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16149", "l": "beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.12", "l": "\"nicotinamide phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60402", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52012", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008678", "l": "2-deoxy-D-gluconate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21065", "l": "[protein]-disulfide + 2 glutathione => [protein]-dithiol + glutathione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63691", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878117", "l": "RUNX3 binds ZFHX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22030", "l": "CoA + taxa-4(20),11-dien-5alpha-yl acetate => acetyl-CoA + taxa-4(20),11-dien-5alpha-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27958", "l": "cytidine + H2O = cytosine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24140", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.185", "l": "\"23S rRNA (guanosine(2251)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33760", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH => a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67297", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24803", "l": "(S)-3-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856951", "l": "PP2A demethylation by PPME1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61171", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35591", "l": "H2 + n sulfur = H(+) + hydrogen sulfide + (n-1) sulfur", "d": [], "t": []}, {"i": "EC:1.12.98.4", "l": "\"sulfhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14321", "l": "morphine + NADP(+) = H(+) + morphinone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30518", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661625", "l": "FVIII is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58621", "l": "N-decanoyl-(2S)-hydroxyglycine => decanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57771", "l": "2-nitrotoluene + NADH + O2 <=> 3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047157", "l": "myelin-proteolipid O-palmitoyltransferase activity", "d": ["Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043779", "l": "cobalt-precorrin-5A acetaldehyde-lyase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39237", "l": "(2E)-triacontenoyl-CoA + H2O => (3R)-hydroxytriacontanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858475", "l": "ppDVL recruits RAC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37720", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980051", "l": "DLL4 binds NOTCH2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22540", "l": "5'-dehydroadenosine + H2O + O2 = 9-riburonosyladenine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050450", "l": "citrate (Re)-synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19812", "l": "(S)-ureidoglycolate + 2 H(+) + H2O <=> CO2 + glyoxylate + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62442", "l": "4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1) => [(1->4)-alpha-D-galacturonosyl methyl ester](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682598", "l": "ATM phosphorylates HERC2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62490", "l": "2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015382", "l": "sodium:sulfate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43655", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30766", "l": "H2O + L-valine + NAD(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59337", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A => AH2 + demethylspheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68510", "l": "(Z)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36384", "l": "carbamoyl adenylate + tobramycin => AMP + H(+) + nebramycin 5'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68627", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39745", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77579", "l": "(9Z)-octadecenoyl-CoA + 1-octanoylglycerol = 1-octanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68134", "l": "CoA + tetradecanoate phytyl ester => phytol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17682", "l": "3-hydroxy-2-methylpropanoate + NAD(+) => 2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28416", "l": "4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+) => gamma-L-glutamylputrescine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30785", "l": "(R)-glycerate + 2 H(+) + NADH => D-glyceraldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44443", "l": "a 1,3-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22192", "l": "(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}, {"i": "EC:2.1.2.3", "l": "\"phosphoribosylaminoimidazolecarboxamide formyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48098", "l": "2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30688", "l": "(4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380574", "l": "Dopamine synaptic vesicle docking and priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.1", "l": "\"deoxyribonuclease II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75933", "l": "taurine + urea => H2O + taurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676168", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785768", "l": "MRN complex binds DNA double strand breaks (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42638", "l": "A + H2O + L-alanine + thio-Mo-molybdopterin => AH2 + L-cysteine + Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797974", "l": "LRRTMs bind NRXNs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388828", "l": "PD-1 binds B7DC and B7H1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73439", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19197", "l": "adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": [], "t": []}, {"i": "EC:2.7.7.51", "l": "\"adenylylsulfate--ammonia adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54853", "l": "H(+) + heptan-4-one + NADPH + O2 => H2O + NADP(+) + propyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23411", "l": "NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72653", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+) => 1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56058", "l": "genistein 7-O-beta-D-glucoside + H(+) + UDP => genistein + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26157", "l": "D-mannose + NADP(+) => D-glucosone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39683", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29900", "l": "ATP + D-xylose(out) + H2O => ADP + D-xylose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17520", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate <=> a long-chain fatty acid + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640316", "l": "DeHA hydrolyses to threonate and oxalate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004837", "l": "tyrosine decarboxylase activity", "d": ["Catalysis of the reaction: L-tyrosine = tyramine + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45946", "l": "4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617820", "l": "Assembly of IFT B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16866", "l": "choloyl-CoA + propanoyl-CoA => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49954", "l": "5,10-dihydrophenazine 1-carboxylate => (10aS)-10,10a-dihydrophenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17346", "l": "(S)-methylmalonyl-CoA + H2O => CoA + H(+) + methylmalonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43580", "l": "A + D-arginine = AH2 + iminoarginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41875", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57799", "l": "4-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481007", "l": "Exocytosis of platelet alpha granule contents (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604712", "l": "Initial activation of proMMP7 by trypsin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74579", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] = N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68996", "l": "2-oxoglutarate + gibberellin A9 + O2 = CO2 + gibberellin A4 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30349", "l": "ADP + ITP => ATP + IDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32773", "l": "2,6-dioxo-6-phenylhexa-3-enoate => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111879", "l": "PIP2 hydrolysis (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805740", "l": "SETD8 methylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953356", "l": "Expression of EXTL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54344", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11578", "l": "AMP + H(+) + thiamine diphosphate => ATP + thiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664850", "l": "ATM binds PEX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38552", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 => (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62400", "l": "(1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75969", "l": "(6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+) => (6-hydroxyhexanoyl)n + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170149", "l": "Translocation of active Cdc25C to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417122", "l": "Elongation and translocation of the telomeric chromosome end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683669", "l": "E protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395764", "l": "atREs binds to nascent CM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033296", "l": "rhamnose binding", "d": ["Binding to the D- or L-enantiomer of rhamnose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047358", "l": "UDP-glucose-glycoprotein glucose phosphotransferase activity", "d": ["Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660980", "l": "p-S276-RELA binds RELB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53084", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74132", "l": "malvidin + UDP-alpha-D-galactose => H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27561", "l": "all-trans-hexaprenyl diphosphate + 3 diphosphate => (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21527", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39418", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58459", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28546", "l": "alpha-D-glucose = alpha-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672980", "l": "Dissociation of RAS:RAF complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53105", "l": "4-hydroxyestrone + S-adenosyl-L-methionine => 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60419", "l": "diglucosyl-enterobactin + H2O <=> H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995330", "l": "COX10 transforms heme to heme O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12173", "l": "alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15312", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57444", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": [], "t": []}, {"i": "EC:3.4.17.17", "l": "\"tubulinyl-Tyr carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4608855", "l": "PRICKLE1 is degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19207", "l": "diphosphate + dUMP + NH4(+) => dCTP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097030", "l": "CENP-A containing nucleosome binding", "d": ["Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009936", "l": "RNASEL cleaves cellular ssRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10991", "l": "H2O + nitrous oxide <=> 2 e(-) + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37309", "l": "glycine + L-asparagine => glycyl-L-asparagine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77608", "l": "Binding of A1CF to stem-looped RNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29772", "l": "arsenate(in) + ATP + H2O => ADP + arsenate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61226", "l": "2-oxosuccinamate + H2O2 + NH4(+) => H2O + L-asparagine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635428", "l": "FadD26, FadD28 transfer LCFA adenylate ester to Pks5 (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213464", "l": "RIPK1 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670412", "l": "Phosphorylation of STATs downstream of KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11108", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.17", "l": "\"chondroitin 6-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.121", "l": "\"aldose 1-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804955", "l": "ATM phosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46717", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757686", "l": "SERPINA6 binds PREDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382096", "l": "Formation of NR-NCOR Corepressor Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044016", "l": "histone H3K4 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51288", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750942", "l": "USP14 deubiquitinates NLRC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72608", "l": "(E)-sinapoyl-AMP + CoA => (E)-sinapoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16500", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41901", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] => 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64730", "l": "(7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38253", "l": "CoA + hexadecanyl octadecanoate => hexadecan-1-ol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714483", "l": "RAC2 translocates to the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68632", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:7.1.1.11", "l": "\"ferredoxin--NAD(+) oxidoreductase (H(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39238", "l": "(3R)-hydroxytriacontanoyl-CoA <=> (2E)-triacontenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53611", "l": "4-hydroxyestrone + O2 <=> (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35202", "l": "(S,S)-tartrate(out) <=> (S,S)-tartrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62809", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106421", "l": "L-glutamate:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59928", "l": "erythritol + NADP(+) = D-erythrose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696323", "l": "CNRs bind CNR agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51701", "l": "S-adenosyl-L-methionine + xanthogalenol => 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693092", "l": "Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047396", "l": "glycosylphosphatidylinositol diacylglycerol-lyase activity", "d": ["Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29212", "l": "H(+)(out) + inosine(in) => H(+)(in) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007686", "l": "RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110307", "l": "REV1 binds AP-dsDNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57384", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.285", "l": "\"(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718020", "l": "PTGFR binds PTGFR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614271", "l": "Autocleavage of ADGRG6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43954", "l": "H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate => 3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65892", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = H2O + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848339", "l": "PNPLA5 hydrolyzes TAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186765", "l": "PLC-gamma binds to the active receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52959", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866269", "l": "ARRB bind GPCRs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696271", "l": "RND1 binds effectors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626938", "l": "Beta-catenin binds SOX proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635839", "l": "ULK3:SUFU dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56008", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149519", "l": "MMACHC decyanates CNCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050320", "l": "tartrate epimerase activity", "d": ["Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61130", "l": "H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase] => O2 + quercetin + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24435", "l": "H2O + oxaloacetate <=> acetate + H(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57262", "l": "GDP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71483", "l": "H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57421", "l": "NADH + 2 oxidized [cytochrome P450] => H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17456", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine <=> ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874979", "l": "ACBD3 binds GOLGB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629917", "l": "NEIL1 Q282TER does not translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390846", "l": "D2D3,4 bind to DA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862380", "l": "HSD17B13 binds lipid droplets (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29520", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63666", "l": "H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20137", "l": "10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.167", "l": "\"10-deacetylbaccatin III 10-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61020", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:2.3.1.311", "l": "\"tRNA carboxymethyluridine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682983", "l": "ATM phosphorylates WHSC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17278", "l": "6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734687", "l": "ORC6 is phosphorylated on T195 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62305", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine => (+)-premalbrancheamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204303", "l": "MRE11 binds cytosolic DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2984226", "l": "PLK1 phosphorylates NEK9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37115", "l": "sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25909", "l": "an alditol + O2 => an aldose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604752", "l": "Initial activation of proMMP13 by MMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047612", "l": "acid-CoA ligase (GDP-forming) activity", "d": ["Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H+ + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047634", "l": "agmatine N4-coumaroyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41773", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GQ1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73929", "l": "griseophenone C + S-adenosyl-L-homocysteine => griseophenone D + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.16", "l": "\"protein-serine/threonine phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047356", "l": "CDP-ribitol ribitolphosphotransferase activity", "d": ["Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676589", "l": "RANKL,sRANKL trimer binds RANK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50901", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O => (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47248", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65672", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15970", "l": "2 glutathione + H(+) + methylarsonate => glutathione disulfide + H2O + methylarsonous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15346", "l": "ATP + L-arginine + L-tyrosine => AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57839", "l": "H2O + O2 + thermospermine <=> 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15311", "l": "biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin] => (2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32107", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine = H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22745", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19858", "l": "a 16alpha-hydroxysteroid + NADP(+) => a 16-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166038", "l": "GPI-bound CD14 binds LPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40204", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103062", "l": "cis-keto-C60-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] = diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964280", "l": "Active Gq binds BTK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39352", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59949", "l": "H2O + prostaglandin F2alpha-CoA => CoA + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018679", "l": "dibenzothiophene-5,5-dioxide monooxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683618", "l": "mRNA3 is translated to protein 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57898", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45724", "l": "(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12659", "l": "a (2R)-2-methylacyl-CoA => a (2S)-2-methylacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730841", "l": "Phosphorylation and activation of VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61224", "l": "H2O + L-asparagine + O2 = 2-oxosuccinamate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63154", "l": "a fatty acid + taurine => an N-fatty acyl-taurine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44306", "l": "a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780979", "l": "CCS transfers Cu to SOD1 (mitochondrial) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64637", "l": "benzoyl-CoA + butan-1-ol => butyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867047", "l": "PTPN3 dephosphorylates EPS15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683792", "l": "p-T68-CHEK2 autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428625", "l": "Vesicular inhibitory amino acid transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001591", "l": "dopamine neurotransmitter receptor activity, coupled via Gi/Go", "d": ["Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297354", "l": "Acrosin Cleavage (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785213", "l": "LIPC dimer binds heparin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051430", "l": "corticotropin-releasing hormone receptor 1 binding", "d": ["Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16897", "l": "a 3beta-hydroxysteroid + a triacylglycerol = a 3beta-hydroxysteroid ester + a diacylglycerol", "d": [], "t": []}, {"i": "EC:2.3.1.77", "l": "\"triacylglycerol--sterol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66418", "l": "ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48628", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341072", "l": "SUMOylation of RARA with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299338", "l": "Activation of TRESK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36608", "l": "2-oxoglutarate + L-arginine + O2 => (2S,3S)-hydroxyarginine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16444", "l": "H2O + L-glutaminyl-[protein] <=> L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481009", "l": "Exocytosis of platelet dense granule content (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112727", "l": "Serine phosphorylation of STATs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16775", "l": "a ganglioside GM1 (d18:1(4E)) + H(+) + UDP => a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53337", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) => H(+) + NADPH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102318", "l": "2-deoxystreptamine glucosyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209815", "l": "Tyrosine is monoiodinated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43555", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794336", "l": "NMDAR binds PSD-95 subfamily members (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27763", "l": "CTP + H2O => CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76048", "l": "(S)-tetrahydropalmatine + S-adenosyl-L-methionine => (S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14602", "l": "L-lysine + O2 => 5-aminopentanamide + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55585", "l": "an adenosine in mRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38696", "l": "a cardiolipin(in) => a cardiolipin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036134", "l": "12-hydroxyheptadecatrienoic acid synthase activity", "d": ["Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696547", "l": "STAMBPL1 is a deubiquitinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72203", "l": "2 chloride(out) + hydrogencarbonate(in) = 2 chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47053", "l": "(2E,6E)-farnesyl diphosphate => alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388560", "l": "EDNRA,EDNRB bind EDNs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74553", "l": "L-serine + tRNA(Ser) => H2O + L-seryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662613", "l": "MT3 exchanges zinc for copper (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22445", "l": "(E)-coniferol + NADP(+) => (E)-coniferaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.137", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25233", "l": "N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate", "d": [], "t": []}, {"i": "EC:5.1.3.24", "l": "\"N-acetylneuraminate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875374", "l": "MET binds LRIG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45786", "l": "3-phenylpropanoate + NH4(+) => 2 H2O + phenylpropanonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050491", "l": "sulcatone reductase activity", "d": ["Catalysis of the reaction: NAD+ + sulcatol = H+ + NADH + sulcatone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64425", "l": "H(+)(out) + L-leucyl-L-proline(out) => H(+)(in) + L-leucyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69613", "l": "beta-D-glucose + D-glucose => H2O + kojibiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39046", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39329", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45892", "l": "an N-acylsphing-4-enine + CDP-ethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56515", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74712", "l": "Dissociation of IRS-P from insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855375", "l": "PTPN22 dissociates from CSK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061658", "l": "URM1 conjugating enzyme activity", "d": ["Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043530", "l": "adenosine 5'-monophosphoramidase activity", "d": ["Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester."], "t": []}, {"i": "RHEA:67916", "l": "adenosine 5'-phosphoramidate + H2O = AMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57639", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10900", "l": "an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine", "d": [], "t": []}, {"i": "EC:2.6.1.60", "l": "\"aromatic-amino-acid--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49789", "l": "chenodeoxycholoyl-CoA + glycine => CoA + glycochenodeoxycholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48335", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57899", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730862", "l": "Autophosphorylation of LYN kinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61048", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54213", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10030", "l": "2-oxoglutarate + H2O2 + NH4(+) => D-glutamate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204311", "l": "AOX1 oxidises PXL to PDXate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805640", "l": "AKT phosphorylates KAT6A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.16", "l": "\"oxazoline dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353500", "l": "Nuclear focus formation by interaction of chSNM1A with PIAS1 upon DNA lesion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32069", "l": "NH4(+) + urate => 8-oxoguanine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58606", "l": "FADH2-C4alpha-hydroperoxide + NAD(+) => FAD + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12063", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52871", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26564", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 2-succinylbenzoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12800", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + scopolamine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54017", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25257", "l": "N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5220959", "l": "TDG excises 5-formylcytosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52132", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390912", "l": "HRH1 binds hist (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44692", "l": "a fatty acyl-CoA + hexadecasphinganine = CoA + H(+) + N-acylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55938", "l": "all-trans-4-hydroxyretinal + H(+) + NADH => all-trans-4-hydroxyretinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53568", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33601", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36755", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.305", "l": "\"UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64239", "l": "atrochrysone carboxyl-[ACP] + H2O <=> atrochrysone carboxylate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807565", "l": "GNLY is transferred to the phagosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047245", "l": "N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944232", "l": "Association of procollagen type XII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634228", "l": "TRAF1 is cleaved by caspases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64767", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18516", "l": "D-mannitol + O2 <=> D-mannose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48076", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65085", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48045", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O => D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694441", "l": "CSNK1D phosphorylates SEC23 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47953", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38959", "l": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.6", "l": "\"acyl-CoA oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161666", "l": "PGA2 is isomerised to PGC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033987", "l": "2-hydroxyisoflavanone dehydratase activity", "d": ["Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70470", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466846", "l": "atRAL can spontaneously react with PE to form NRPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73855", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose = 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15516", "l": "ATP + keto-D-tagatose <=> ADP + H(+) + keto-D-tagatose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31751", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44940", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004958", "l": "prostaglandin F receptor activity", "d": ["Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22047", "l": "ATP + H(+)(in) + H2O + K(+)(out) <=> ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72346", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44322", "l": "decanoate + glycerol + H(+) => 1-decanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33208", "l": "ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48825", "l": "GDP-beta-L-fucose + Lc4Cer => a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811454", "l": "MAPKs phosphorylate PP2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67011", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47211", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14442", "l": "acetyl-CoA + gentamicin C => CoA + H(+) + N(3)-acetylgentamycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047916", "l": "GDP-6-deoxy-D-talose 4-dehydrogenase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709109", "l": "DHFR dimer binds DHFR inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034597", "l": "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50906", "l": "H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine => L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012074", "l": "FGFR3c P250R mutant binds to ligand with enhanced affinity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660192", "l": "VDR agonists bind VDR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981539", "l": "C3b binds to cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832782", "l": "p-S232-S237-P is further phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202969", "l": "Caspase mediated cleavage of beta-catenin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22384", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34920", "l": "thiamine(in) => thiamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61416", "l": "(S)-8-oxocitronellyl enol = cis-trans-nepetalactol", "d": [], "t": []}, {"i": "EC:5.5.1.34", "l": "\"(+)-cis,trans-nepetalactol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83677", "l": "C4 deamination of cytidine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669240", "l": "FLNA binds PAK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46893", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41598", "l": "(5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50179", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190260", "l": "FGFR2b binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36056", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O => a 2,4-dihydroxypteridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60398", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628807", "l": "Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60829", "l": "a 5'-end triphospho-adenosine in mRNA + H2O => a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.12", "l": "\"ABC-type capsular-polysaccharide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31802", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77270", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol <=> 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29159", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56775", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 <=> 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52876", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20533", "l": "H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48618", "l": "glycine + leukotriene E4 => H2O + leukotriene D4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19690", "l": "L-rhamnulose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48841", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50639", "l": "a 3-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444100", "l": "PROT mediates L-proline uptake (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662647", "l": "MT4 binds copper (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170159", "l": "Translocation of Cdc25 to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20401", "l": "a beta-lactam + H2O = a substituted beta-amino acid", "d": [], "t": []}, {"i": "EC:3.5.2.6", "l": "\"beta-lactamase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13638", "l": "H(+) + methane + NADH + O2 => H2O + methanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186780", "l": "PI3-kinase binds to the active receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59005", "l": "dodecanal + H2O + O2 => dodecanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74975", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10339", "l": "citrate <=> D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76379", "l": "n H(+)(out) + L-histidine(out) = n H(+)(in) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164510", "l": "Conformational change in gp120 of Env oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726580", "l": "PGR binds PGR agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52036", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate = L-isoleucine + tuberonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696358", "l": "TREM,CD300 binds lipids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28651", "l": "inosine + O2 = 9-riburonosylhypoxanthine + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.1.3.28", "l": "\"nucleoside oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016464", "l": "chloroplast protein-transporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047194", "l": "indoleacetylglucose-inositol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35085", "l": "acetate + N'-monoacetylchitobiose-6'-phosphate => diacetylchitobiose-6'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62701", "l": "H2O + naphtopyrone YWA1 => acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73514", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 <=> CO2 + formaldehyde + pilosin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16738", "l": "H(+) + NADH + O2 + toluene => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981926", "l": "RAC1 and CDC42 activate PAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694304", "l": "nsp14 binds nsp12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76417", "l": "3',3'-cGAMP(in) + n H(+)(in) => 3',3'-cGAMP(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76881", "l": "acetoin + H(+) + NADH + NH4(+) => 3-aminobutan-2-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13027", "l": "3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => 3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29535", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.260", "l": "\"dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451310", "l": "Activation of Edited Kainate receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096538", "l": "Defective LFNG does not transfer GlcNAc to Pre-NOTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25510", "l": "(1S,5S)-sabinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40158", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58733", "l": "5-methyl-CTP + H2O => 5-methyl-CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40207", "l": "(2E)-tetradecenedioyl-CoA + H2O = (3S)-hydroxytetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013159", "l": "CDC42 GEFs activate CDC42 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62390", "l": "[(1->2)-beta-D-glucosyl](n-2) + sophorose => [(1->2)-beta-D-glucosyl](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0080161", "l": "auxin transmembrane transporter activity", "d": ["Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10913", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48005", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71737", "l": "formate + succinyl-CoA => formyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0003688", "l": "DNA replication origin binding", "d": ["Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11267", "l": "H(+) + NADH + O2 <=> H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17173", "l": "glutathionylspermidine + H2O = glutathione + spermidine", "d": [], "t": []}, {"i": "EC:3.5.1.78", "l": "\"glutathionylspermidine amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134962", "l": "DHX36 binds DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4167511", "l": "HLCS biotinylates ACACB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67242", "l": "adenosine + H(+) + L-methionine => (R)-S-adenosyl-L-methionine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428990", "l": "Arachidonate diffuses across the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65701", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64734", "l": "(11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26213", "l": "9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.42", "l": "\"aphidicolan-16beta-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047348", "l": "glycerol-3-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28279", "l": "3-sulfino-L-alanine + H2O => H(+) + L-alanine + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193646", "l": "NGF binding to p75NTR inactivates RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62853", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45044", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 = 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626817", "l": "PKC phosphorylates NCF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111970", "l": "PKC phosphorylates GRK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428918", "l": "Dissociation of the TP:G13 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23893", "l": "3-nitropropanoate + NADP(+) => 3-nitroacrylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52010", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26402", "l": "all-trans-10'-apo-beta-carotenal + O2 => (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33291", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51704", "l": "S-adenosyl-L-methionine + xanthohumol = 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.339", "l": "\"xanthohumol 4-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.9", "l": "\"dihydroxy-acid dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39114", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788999", "l": "HV1-mediated H+ transfer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11728", "l": "cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.163", "l": "\"cyclopentanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11893", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine => H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70742", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202245", "l": "Phosphorylation of TBSMs in LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59489", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635480", "l": "FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004315", "l": "3-oxoacyl-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18983", "l": "2-dehydropantolactone + H(+) + NADPH => (R)-pantolactone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62758", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102378", "l": "steviolmonoside glucosyltransferase activity", "d": ["Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15645", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] = 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": [], "t": []}, {"i": "EC:1.19.6.1", "l": "\"nitrogenase (flavodoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14376", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694575", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71103", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) = L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471314", "l": "HNP1-3 bind CD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74336", "l": "O-2-methylbutanoyl-(R)-carnitine(in) => O-2-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36856", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53495", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) <=> 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757688", "l": "SERPINA6 binds PREDN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56126", "l": "AH2 + diphosphate + nonaflavuxanthin => A + all-trans-lycopene + dimethylallyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61440", "l": "acetyl-CoA + S-(2-succino)-L-cysteine = CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37982", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28155", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399981", "l": "AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051429", "l": "corticotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045522", "l": "interleukin-26 receptor binding", "d": ["Binding to an interleukin-26 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160152", "l": "tRNA pseudouridine(31) synthase activity", "d": ["Catalysis of the reaction: uridine(31) in tRNA = pseudouridine(31) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192704", "l": "Synthesis of PB1-F2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13501", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.14", "l": "\"biotin carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:1902248", "l": "5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding", "d": ["Binding to 5-O-phosphono-alpha-D-ribofuranosyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977605", "l": "Factor H displaces Bb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71004", "l": "L-histidine(in) + L-phenylalanine(out) => L-histidine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19157", "l": "D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.82", "l": "\"xylonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21843", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48547", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine <=> [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749647", "l": "CES2 hydrolyzes ASA- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29086", "l": "(S)-malate + ubiquinone-8 <=> oxaloacetate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209295", "l": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54756", "l": "deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": [], "t": []}, {"i": "EC:2.5.1.143", "l": "\"pyridinium-3,5-biscarboxylic acid mononucleotide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450975", "l": "isocitrate <=> citrate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69127", "l": "Formation of the Flap Intermediate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426489", "l": "RISC binds inexactly matching target RNAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49097", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64791", "l": "(E)-cinnamate + ATP + CoA <=> (E)-cinnamoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18576", "l": "dihydrochelirubine + H(+) + O2 <=> chelirubine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008923", "l": "lysine decarboxylase activity", "d": ["Catalysis of the reaction: L-lysine + H+ = cadaverine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030986", "l": "low molecular weight kininogen binding", "d": ["Binding to a kininogen of low molecular mass."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42671", "l": "L-rhamnofuranose + NADP(+) <=> H(+) + L-rhamnono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864569", "l": "WWOX binds TFAP2C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.29", "l": "\"N-acylhexosamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390593", "l": "ATP Hydrolysis By Myosin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657642", "l": "ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73722", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38286", "l": "itaconate + succinyl-CoA <=> itaconyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047708", "l": "biotinidase activity", "d": ["Catalysis of the reaction: biotin amide + H2O = biotin + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000121", "l": "glycerol-1-phosphatase activity", "d": ["Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679044", "l": "FKBP1A binds sirolimus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175258", "l": "2-LTR formation due to circularization of viral DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197187", "l": "ACS transforms to QUIN non-enzymatically (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610720", "l": "PKA phosphorylates GLI3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55426", "l": "(3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59648", "l": "D-xylotriono-1,5-lactone + H2O = D-xylotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13202", "l": "glycine + L-arginine => guanidinoacetate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0000332", "l": "template for synthesis of G-rich strand of telomere DNA activity", "d": ["Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700156", "l": "Active ALK dimer binds IRS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36378", "l": "ATP + carbamoyl phosphate + H2O <=> carbamoyl adenylate + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11807", "l": "an aromatic aldehyde + H2O + NAD(+) <=> an aromatic carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033855", "l": "nicotianamine aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73758", "l": "2 H(+)(out) + histamine(in) <=> 2 H(+)(in) + histamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57316", "l": "ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.224", "l": "\"cytidine diphosphoramidate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27305", "l": "7-chloro-L-tryptophan + O2 <=> 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110468", "l": "Activation of DAkt1 by DPDK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48404", "l": "apo-[aryl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70444", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11858", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390593", "l": "ATP Hydrolysis By Myosin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.178", "l": "\"beta-porphyranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55874", "l": "2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH => anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26503", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35651", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA = an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871226", "l": "RET binds GFRA1,GFRA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214324", "l": "Collagen type VII dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21208", "l": "H2O + O-phospho-L-serine = L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001084", "l": "L-arabinofuranose binding", "d": ["Binding to L-arabinofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29014", "l": "2-oxoglutarate(in) + H(+)(in) <=> 2-oxoglutarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40877", "l": "(2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2 => (9Z,12Z)-octadecadienoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67511", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38657", "l": "D-glucose + tulipalin B => 6-tuliposide B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.109", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15861", "l": "3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.28", "l": "\"ADP-phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46690", "l": "3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2 => (25S)-3-oxocholest-4-en-26-oyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428750", "l": "Gq activation by TP receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35513", "l": "glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35267", "l": "ethanol(in) = ethanol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52204", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.23", "l": "\"chloroacetanilide N-alkylformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15743", "l": "2,5-dichlorohydroquinone + H(+) + NADH => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64530", "l": "2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61641", "l": "H(+) + isophthalyl-CoA => benzoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209096", "l": "E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785181", "l": "LMF1,2 bind LIPC dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28542", "l": "fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.29", "l": "\"fluoroacetyl-CoA thioesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754964", "l": "ADA deamidates RBV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75954", "l": "2-oxoglutarate + O2 + oripavine <=> CO2 + formaldehyde + neomorphinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712195", "l": "ANO2 dimer binds Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58432", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54047", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 7-epi-alpha-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59636", "l": "D-xylotriose + O2 = D-xylotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32859", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20448", "l": "L-arogenate + oxaloacetate <=> L-aspartate + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35964", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A => fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016767", "l": "geranylgeranyl-diphosphate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672969", "l": "Phosphorylation of RAF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15427", "l": "2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX => coproporphyrinogen III + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70765", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74679", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) = UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30193", "l": "15,9'-di-cis-phytofluene + plastoquinol-9 => 15-cis-phytoene + plastoquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602712", "l": "TICAM1 deficiency blocks TLR3 pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48683", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031741", "l": "type B gastrin/cholecystokinin receptor binding", "d": ["Binding to a type B gastrin/cholecystokinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77339", "l": "(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38843", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043899", "l": "phosphoserine:homoserine phosphotransferase activity", "d": ["Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30394", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine <=> 2-oxoglutaramate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64253", "l": "glycine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21913", "l": "CoA + H(+) + O2 + pyruvate => acetyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48909", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59019", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) <=> CO2 + cycloeucalenone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031770", "l": "growth hormone-releasing hormone receptor binding", "d": ["Binding to a growth hormone-releasing hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54735", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093330", "l": "EPHB binds p120-RasGAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74395", "l": "2 (S)-lactate(in) + prostaglandin E1(out) = 2 (S)-lactate(out) + prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56818", "l": "a pyrimidine nucleobase + D-ribose => a pyrimidine ribonucleoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085318", "l": "SUMOylation of NCOA2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009977", "l": "proton motive force dependent protein transmembrane transporter activity", "d": ["Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64168", "l": "2-ethyl-L-serine = (2S)-2-aminobutanoate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36406", "l": "a cholesterol ester + H2O <=> a fatty acid + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033794", "l": "sarcosine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77161", "l": "H(+) + N-acetyl-1-seleno-beta-D-glucosamine + phosphate + UDP => H2O + selenophosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56628", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O = chloride + 2 H(+) + maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69727", "l": "2-phenylacetate + ATP + H(+) = diphosphate + phenylacetyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679775", "l": "COMT binds COMT Inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29751", "l": "acetoacetate(in) = acetoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10145", "l": "a ribonucleoside 3'-phosphate + H2O => a ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.8", "l": "\"Fas-activated serine/threonine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48930", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869590", "l": "The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16136", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044025", "l": "histone H2BS14 kinase activity", "d": ["Catalysis of the reaction: histone H2B-serine (position 14) + ATP = histone H2B-phosphoserine (position 14) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 14 of histone H2B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005222", "l": "intracellular cAMP-activated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30339", "l": "H(+) + L-tryptophan = CO2 + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014433", "l": "RHOG GEFs activate RHOG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49860", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047125", "l": "delta1-piperideine-2-carboxylate reductase activity", "d": ["Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71831", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) = chloride(in) + creatine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114671", "l": "vWF binds to collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69037", "l": "5beta-androstane-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25491", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102479", "l": "quercetin 3-O-beta:-D-galactosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose = quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852317", "l": "PLK1 phosphorylates GTSE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29829", "l": "Mg(2+)(out) => Mg(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22131", "l": "(1S,2R,4S)-borneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0004559", "l": "alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005131", "l": "growth hormone receptor binding", "d": ["Binding to a growth hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199518", "l": "C3d-complexed antigen binds to complement receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0005343", "l": "organic acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)."], "t": []}, {"i": "REACT:R-HSA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26032", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.160", "l": "\"caffeine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17758", "l": "H(+) + L-methionine => 3-(methylsulfanyl)propanamine + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20024", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18688", "l": "H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41289", "l": "sphing-4-enine + tetradecanoate => H2O + N-tetradecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66277", "l": "tigogenin + UDP-alpha-D-glucose => H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392749", "l": "Transport of L1 into endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050621", "l": "tryptophan alpha,beta-oxidase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913446", "l": "Interleukin-5 is a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60364", "l": "H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31608", "l": "rhodopin => all-trans-lycopene + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15458", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => catechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033221", "l": "ATPase-coupled urea transmembrane transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)."], "t": []}, {"i": "RHEA:32803", "l": "ATP + H2O + urea(out) = ADP + H(+) + phosphate + urea(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29051", "l": "2 H(+)(in) + H2 + menaquinone-8 = 2 H(+)(out) + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30828", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.15", "l": "\"succinyl-CoA:(R)-benzylsuccinate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29382", "l": "dGMP + H2O <=> 2'-deoxyguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619756", "l": "NR1H2 binds ABCA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70573", "l": "argininosuccinate <=> fumarate + arginine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17703", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate => ATP + geranoyl-CoA + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69238", "l": "4-hydroxybutylnitrile + sulfate + sulfur => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0061920", "l": "protein propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide."], "t": []}, {"i": "RHEA:54020", "l": "L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794523", "l": "SLC22A1 transports Cipro into renal cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848110", "l": "SOCS3 binds activated PTK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52715", "l": "dTMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19457", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 = catechol + H2O + 2 NADP(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.14.13.31", "l": "\"2-nitrophenol 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25164", "l": "A + butanoyl-CoA = (2E)-butenoyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58460", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61793", "l": "ATP + L-tryptophan => diphosphate + L-tryptophyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53530", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67487", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032502", "l": "Activated NTRK2 binds FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31435", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.82", "l": "\"alpha-santalene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37227", "l": "(E,E)-sorbate + H(+) = (E)-1,3-pentadiene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76421", "l": "(8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50917", "l": "a carboxylate + ATP + H(+) + NADPH => AMP + an aldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984689", "l": "Kinesin-7 is a dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22534", "l": "(3S)-hydroxyoctanedioyl-CoA => (2E)-octenedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17382", "l": "(9Z,12Z)-octadecadienoate => (9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54651", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46915", "l": "H2O + juvenile hormone III <=> H(+) + juvenile hormone III carboxylate + methanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68322", "l": "1D-myo-inositol 2,5-bisphosphate + phosphate => 1D-myo-inositol 2,4,5-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34201", "l": "bracteatin 6-O-beta-glucoside + H2O => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38004", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate => 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1006143", "l": "CD46 binds C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62887", "l": "O2 + 4 semiviriditoxin <=> 2 (M)-viriditoxin + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61034", "l": "5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75202", "l": "H2O + triuret <=> 1-carboxybiuret + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018560", "l": "protocatechuate 3,4-dioxygenase type II activity", "d": ["Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32164", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine => AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41241", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]-acylsphin-4-enine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990882", "l": "CDK1 phosphorylates NUP98 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299487", "l": "Precursor proteins enter TIMM23 SORT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.25", "l": "\"4-alpha-glucanotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10093", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42318", "l": "an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034793", "l": "cyclopropanecarboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61584", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48671", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72103", "l": "Formation of pre-mRNPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73770", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate <=> diphosphate + preechinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25860", "l": "GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.4.39", "l": "\"GTP cyclohydrolase IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37930", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68679", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66359", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) <=> (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434053", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050423", "l": "thiamine oxidase activity", "d": ["Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54969", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010420", "l": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392263", "l": "AVP(20-28) binds AVPR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70095", "l": "(R)-5-methyl-tetronate + o-quinone methide = peniphenone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111879", "l": "PIP2 hydrolysis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69922", "l": "inosine(out) + 2 Na(+)(out) <=> inosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674095", "l": "PDGFRs bind type II TKI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805638", "l": "KAT6A acetylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810376", "l": "ING2 binds PI5P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77106", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O <=> 2-(9Z-octadecenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45213", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) => CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40442", "l": "6-sulfo-beta-D-quinovose <=> 6-deoxy-6-sulfo-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37220", "l": "A + D-valine + H2O => 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54603", "l": "2-oxoglutarate + O2 + octanoyl-CoA <=> 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69894", "l": "Na(+)(out) + thymidine(out) <=> Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042972", "l": "licheninase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168136", "l": "NOTCH3 binds DLL4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35048", "l": "adenylyl-molybdopterin + H(+) + molybdate => AMP + H2O + Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445124", "l": "Patched binds Smoothened (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435244", "l": "PECAM1 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921145", "l": "Activated chicken TAK1 dissociates from the activated TLR3 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218821", "l": "PDK1 phosphorylates PKC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482772", "l": "Release of platelet cytosolic components (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390425", "l": "FAR1 reduces PalmCoA to HXOL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40478", "l": "1,2,3-tributanoylglycerol + H2O <=> butanoate + dibutanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050096", "l": "methylaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77539", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62149", "l": "dGTP + dTMP => dGDP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031709", "l": "gastrin-releasing peptide receptor binding", "d": ["Binding to a gastrin-releasing peptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70828", "l": "L-arginine(in) + L-lysine(out) => L-arginine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12401", "l": "beta-nicotinamide D-ribonucleotide + H2O => NH4(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73376", "l": "biotin(out) + 2 Na(+)(out) => biotin(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.45", "l": "\"complement factor I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53688", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.243", "l": "\"toluene 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659989", "l": "Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444523", "l": "CXCR5 binds CXCL13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77101", "l": "2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil => 5-hydroxymethyl-dUMP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647660", "l": "GSDME (1-270) binds PIPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097244", "l": "flavonol binding", "d": ["Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55149", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202947", "l": "Caspase mediated cleavage of APC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665413", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73365", "l": "beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029473", "l": "Branching and elongation of mother and daughter filaments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25145", "l": "3-hydroxyanthranilate + H(+) + L-alanine => 3-hydroxy-L-kynurenine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451310", "l": "Activation of Edited Kainate receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36695", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.302", "l": "\"L-demethylnoviosyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252133", "l": "ATP6AP1 binds V-ATPase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28185", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate <=> (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102366", "l": "7-beta-hydroxytaxusin 2-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27387", "l": "maleate + NH4(+) => H2O + maleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15026", "l": "S-adenosyl-L-methionine + xanthosine => 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46510", "l": "catechol + NAD(+) + nitrite => NADH + nitrobenzene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22440", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.18", "l": "\"UDP-galactose--UDP-N-acetylglucosamine galactose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36806", "l": "2-hydroxy-2,3-dihydrogenistein <=> genistein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634861", "l": "NPAS4 binds ARNT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25803", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015638", "l": "microcin transmembrane transporter activity", "d": ["Enables the transfer of a microcin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15023", "l": "4-O-feruloyl-D-quinate + CoA => (E)-feruloyl-CoA + L-quinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855648", "l": "SALM3 binds LAR-RPTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0120241", "l": "2-iminobutanoate/2-iminopropanoate deaminase", "d": ["Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17."], "t": []}, {"i": "EC:3.5.99.10", "l": "\"2-iminobutanoate/2-iminopropanoate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19432", "l": "[beta-adrenergic receptor] + ATP <=> [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33031", "l": "H(+) + keto-D-fructose + NADH = D-sorbitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.56", "l": "\"7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43107", "l": "AH2 + an N-acyleicosasphinganine + O2 <=> A + an N-acyleicosasphing-4-enine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77255", "l": "beta-D-glucosylceramide(in) = beta-D-glucosylceramide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19277", "l": "ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": [], "t": []}, {"i": "EC:6.1.1.26", "l": "\"pyrrolysine--tRNA(Pyl) ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70665", "l": "4-hydroxy-L-proline(out) + H(+)(out) => 4-hydroxy-L-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38192", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone => 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014433", "l": "RHOG GEFs activate RHOG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13049", "l": "D-glucuronate = D-fructuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950354", "l": "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70807", "l": "4-deoxy-4-sulfo-D-erythrose = 4-deoxy-4-sulfo-D-erythrulose", "d": [], "t": []}, {"i": "EC:5.3.1.37", "l": "\"4-deoxy-4-sulfo-D-erythrose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089971", "l": "Secretion of collagens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046526", "l": "D-xylulose reductase activity", "d": ["Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53783", "l": "beta-muricholate + lithocholoyl-CoA <=> beta-muricholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222376", "l": "NOX2 generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15184", "l": "an acyl-CoA(out) + ATP + H2O <=> ADP + an acyl-CoA(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33877", "l": "(9Z)-octadecenoate + cholesterol + H(+) => cholesteryl (9Z-octadecenoate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029460", "l": "PAK1 phosphorylates LIMK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65147", "l": "2-oxoglutarate + berkeleyone A + O2 <=> CO2 + H2O + preaustinoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784861", "l": "HSPG binds LPL dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28577", "l": "H(+)(in) + sulfate(in) <=> H(+)(out) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74747", "l": "myricetin + S-adenosyl-L-methionine = 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662615", "l": "MT1X binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205118", "l": "TRAF6 polyubiquitinates NRIF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798372", "l": "ATM phosphorylates DYRK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20191", "l": "H(+) + NADH + uracil => 5,6-dihydrouracil + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183072", "l": "EGFR non-clathrin mediated endocytosis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35414", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside <=> an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351901", "l": "Caspase-mediated cleavage of MST3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617182", "l": "PRKACA phosphorylates PLN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50105", "l": "taurine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32826", "l": "phosphate(in) <=> phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835949", "l": "HIV Tat72 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29129", "l": "a menaquinone + H2O + nitrite => a menaquinol + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32493", "l": "10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200646", "l": "Cytosolic folate export across the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804100", "l": "HMGB1 binds LPS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67276", "l": "H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20990", "l": "AMP + 2 H(+) + 2 phosphate => ATP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051022", "l": "Rho GDP-dissociation inhibitor binding", "d": ["Binding to a Rho GDP-dissociation inhibitor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035595", "l": "N-acetylglucosaminylinositol deacetylase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701147", "l": "TRPV1 binds TRPV1 blockers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039556", "l": "MDA-5 binding", "d": ["Binding to MDA-5, a cytoplasmic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12388", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67615", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047988", "l": "hydroxyacid-oxoacid transhydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15559", "l": "ADP + H(+) + Ni(2+)(in) + phosphate => ATP + H2O + Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17101", "l": "H2O + O-acyl-(R)-carnitine = (R)-carnitine + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.28", "l": "\"acylcarnitine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68671", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033858", "l": "N-acetylgalactosamine kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0038064", "l": "collagen receptor activity", "d": ["Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31347", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O = 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": [], "t": []}, {"i": "EC:3.2.1.175", "l": "\"beta-D-glucopyranosyl abscisate beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47511", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isolithocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51653", "l": "D-mannonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191636", "l": "Phosphorylation of Cx43 by c-src (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835121", "l": "Heparin binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0015114", "l": "phosphate ion transmembrane transporter activity", "d": ["Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other."], "t": []}, {"i": "RHEA:32823", "l": "phosphate(in) = phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667563", "l": "AVPR2 bind desmopressin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61336", "l": "ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28012", "l": "propanoate + succinyl-CoA => propanoyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913446", "l": "Interleukin-5 is a homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186798", "l": "GAP binds to PDGF-beta receptors only (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20284", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate <=> (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30657", "l": "ADP + dUDP => ATP + dUMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54982", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685597", "l": "RTC binds SARS-CoV-1 genomic RNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734697", "l": "Expression of SMYD1 (BOP) in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9680443", "l": "ROCK1,2 bind ROCKi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36496", "l": "alpha-D-glucose + ATP => ADP + alpha-D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46832", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42894", "l": "5'-deoxyinosine + NH4(+) => 5'-deoxyadenosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25819", "l": "H2O + norspermine + O2 <=> 3-aminopropanal + H2O2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52911", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 <=> 3-dimethylallyl-4-hydroxymandelate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3240957", "l": "Formation of PRC2-EZH2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40477", "l": "butanoate + dibutanoylglycerol + H(+) => 1,2,3-tributanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793901", "l": "Expression of DLL3 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57633", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28848", "l": "Li(+)(in) + melibiose(in) => Li(+)(out) + melibiose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21667", "l": "4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28771", "l": "(2E)-hexadecenoyl-CoA = (9Z)-hexadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56530", "l": "6-chloro-D-tryptophan + FAD + 2 H2O => chloride + D-tryptophan + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47295", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36165", "l": "ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047370", "l": "succinate-citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11060", "l": "ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": [], "t": []}, {"i": "EC:6.1.1.5", "l": "\"isoleucine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37927", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029268", "l": "Phosphorylation and activation of PLCG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008693", "l": "(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58748", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine = H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626816", "l": "PIN1 binds p-S345-NCF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754964", "l": "ADA deamidates RBV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14591", "l": "chrysoeriol + H(+) + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15575", "l": "H(+) + melatonin + S-adenosyl-L-homocysteine => N-acetylserotonin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25994", "l": "(+)-epi-isozizaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59692", "l": "D-cellotriono-1,5-lactone + H2O = D-cellotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21166", "l": "a carboxylate + an alcohol + H(+) => a carboxylic ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380008", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726621", "l": "PGR binds PGR antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602458", "l": "Activation of proMMP10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480204", "l": "POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47006", "l": "L-threonyl-[protein] + phosphate => H2O + O-phospho-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75187", "l": "2,5-dihydroxybenzoyl-CoA + H2O = 2,5-dihydroxybenzoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65191", "l": "2-oxoglutarate + berkeleyone B + O2 <=> berkeleydione + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381109", "l": "IRE1 binds IRE1 forming dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247839", "l": "Retromer associates with WLS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655240", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010301", "l": "xanthoxin dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + xanthoxin = (+)-abscisic aldehyde + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16585", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:2.8.1.8", "l": "\"lipoyl synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432148", "l": "Fgr may phosphorylate p38 MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614544", "l": "Sulfite is oxidized to sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28255", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA => (3Z)-hex-3-en-1-yl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56233", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66341", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73729", "l": "Formation of SL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43509", "l": "2,5-diformylfuran + H2O => 2-(dihydroxymethyl)-5-formylfuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788628", "l": "p-Y-STATs dissociate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35169", "l": "minocycline(out) => minocycline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351936", "l": "Caspase-mediated cleavage of claspin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432513", "l": "CLK is phosphorylated by DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106439", "l": "L-lysine:L-arginine antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)."], "t": []}, {"i": "RHEA:70827", "l": "L-arginine(in) + L-lysine(out) = L-arginine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61571", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940134", "l": "FOLR2 binds FOLA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12367", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) <=> a quinol + beta-nicotinamide D-riboside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681596", "l": "3CLp dimer binds α-Ketoamides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69708", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-galactose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381668", "l": "cAMP activates EPAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61035", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine <=> 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40594", "l": "decanedioyl-CoA + H2O <=> CoA + decanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69393", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50318", "l": "ethanol + H(+) + octadecanoate => ethyl octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015129", "l": "lactate transmembrane transporter activity", "d": ["Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33461", "l": "NADP(+) + zymosterol => H(+) + NADPH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863727", "l": "STON2 is neddylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65723", "l": "2-oxoglutarate + butyl sulfate + O2 <=> butanal + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.40", "l": "\"serralysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052850", "l": "NADPH-dependent dihydrocurcumin reductase activity", "d": ["Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017835", "l": "NOTCH1 coactivator complex binds NOTCH3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74565", "l": "aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP => aldosterone hemiacetal + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.4", "l": "\"rubredoxin--NAD(P)(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17704", "l": "ATP + geranoyl-CoA + hydrogencarbonate <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56978", "l": "4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin] => 4-methylphenol + H2O + 2 oxidized [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25519", "l": "an acyl-CoA + tropine <=> CoA + H(+) + O-acyltropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30443", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}, {"i": "EC:2.3.2.18", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37614", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56253", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28070", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o", "d": [], "t": []}, {"i": "EC:2.5.1.141", "l": "\"heme o synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57326", "l": "CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12398", "l": "dTDP-D-galacturonate + 3 H(+) + 2 NADPH => dTDP-D-galactose + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034839", "l": "menth-2-enone hydratase activity", "d": ["Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173631", "l": "Activation of C1s (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50325", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388833", "l": "Phosphorylation of CTLA-4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22688", "l": "D-alanine + H2O + O2 = H2O2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55325", "l": "11-cis-retinol + hexadecanoyl-CoA => 11-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74730", "l": "Insulin degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77345", "l": "5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate => N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823958", "l": "EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604752", "l": "Initial activation of proMMP13 by MMP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13608", "l": "2 L-ascorbate + O2 <=> 2 H2O + 2 L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.115", "l": "\"anthocyanidin 3-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35930", "l": "paromamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685208", "l": "CCDC59:TTF1 binds SFTPB gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54307", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate <=> n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102352", "l": "phosphatidate kinase activity", "d": ["Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010308", "l": "acireductone dioxygenase (Ni2+-requiring) activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + CO + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909729", "l": "Activation of JAK kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67227", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73299", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) = (S)-malate(in) + H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050224", "l": "prunasin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29518", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30947", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.84", "l": "\"10-epi-gamma-eudesmol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801101", "l": "RABGGTA binds RABGGTB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963851", "l": "VD3 dissociates from GC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71447", "l": "D-alanine(in) + Na(+)(in) = D-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692146", "l": "Expression of DHH in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858489", "l": "ppDVL binds DAAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74390", "l": "formamide(out) <=> formamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420206", "l": "Phosphorylation of SRC-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46333", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47321", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate => 3-oxo-3-phenylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140214", "l": "TP53 stimulates PMAIP1 (NOXA) expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784189", "l": "JAKs bind LIFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399930", "l": "Activation of PAK by Rac1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60790", "l": "CO2 + gibberellin A9 + H2O => gibberellin A24 + H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088134", "l": "PLK1 phosphorylates FOXM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-874087", "l": "SGT1 binds HSP90 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22373", "l": "H2O + O2 + propionate 3-nitronate => 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-844438", "l": "NLRP1 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005119", "l": "smoothened binding", "d": ["Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867041", "l": "EGFR phosphorylates EPS15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33033", "l": "D-sorbitol + NAD(+) => H(+) + keto-D-fructose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56136", "l": "2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.7", "l": "\"peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14540", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O <=> 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58081", "l": "1-docosanoylglycerol + H2O => docosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949580", "l": "F1Fo ATP synthase dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132248", "l": "C4b binds to target cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39597", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53934", "l": "19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30948", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-gamma-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43468", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47310", "l": "6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60441", "l": "H2O + methyl acetate => acetate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015653", "l": "glycine betaine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42833", "l": "(2E)-octenal + H(+) + pyruvate => (S)-3-acetyloctanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52393", "l": "ATP + D-erythronate => 4-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40777", "l": "D-alpha-phenylglycine + NH4(+) => 2-amino-2-phenylacetonitrile + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31831", "l": "(2E,6E)-farnesyl diphosphate = delta-guaiene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.93", "l": "\"delta-guaiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18504", "l": "ergosterol + NADP(+) <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49734", "l": "CO2 + H2O + violacein => H(+) + O2 + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25908", "l": "an alditol + O2 = an aldose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696958", "l": "USP44 deubiquitinates CDC20 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106432", "l": "queuosine nucleosidase activity", "d": ["Catalysis of the reaction: a N-D-queuosine + H2O = queuine + D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9822532", "l": "ADAMTS13 cleaves VWF multimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23124", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": [], "t": []}, {"i": "EC:4.1.1.39", "l": "\"ribulose-bisphosphate carboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57192", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430201", "l": "p-SLP-76:ADAP binds Ena/VASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77157", "l": "1D-myo-inositol 1,4,5-trisphosphate + phosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60727", "l": "dodecanal + H2O + NADP(+) <=> dodecanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797712", "l": "CDK12 stimulates expression of DNA repair genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73354", "l": "ATP + beta-alanine + histamine <=> AMP + carcinine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43906", "l": "all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19118", "l": "dopamine + 2 L-ascorbate + O2 => (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54652", "l": "peregrinol diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.174", "l": "\"peregrinol diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72451", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) = a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166726", "l": "Activation of MASPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44124", "l": "hexadecanoyl-CoA + tetradecan-1-ol = CoA + tetradecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72876", "l": "anthocyanin A7 + malonyl-CoA => anthocyanin A9 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19559", "l": "9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O => AH2 + O2 + pregna-4,9(11)-diene-3,20-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51547", "l": "D-ribulose <=> D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034572", "l": "monodemethylisoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73408", "l": "(S,S)-tartrate(in) + sulfate(out) => (S,S)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19106", "l": "4-aminobutanal + H2O + NAD(+) => 4-aminobutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63784", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16986", "l": "3-oxoadipate + NADP(+) => H(+) + maleylacetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57668", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785898", "l": "IL4R binds JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432825", "l": "HMGB1 binds TLR4:LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481044", "l": "Surface deployment of platelet alpha granule membrane components (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706319", "l": "Active FLT3 binds to SLA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004991", "l": "parathyroid hormone receptor activity", "d": ["Combining with parathyroid hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46018", "l": "H(+) + NADH + progesterone => (20R)-20-hydroxypregn-4-en-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374896", "l": "Uptake of Noradrenaline (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38746", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31094", "l": "acetyl-CoA + dodecanoyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5444516", "l": "Formation of MSH2:MSH6 Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222128", "l": "NOC2L binds TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27697", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030793", "l": "3'-demethylstaurosporine O-methyltransferase activity", "d": ["Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H+ + staurosporine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32477", "l": "glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine => glycine + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60680", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) = (+)-artemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44565", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate => 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166015", "l": "Association of LBP with LPS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21944", "l": "ATP + D-cellobiose = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.85", "l": "\"beta-glucoside kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380586", "l": "loading of Serotonin in synaptic vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167429", "l": "The receptor:G-protein complex  binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696267", "l": "RND3 binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202692", "l": "PIP3 binds to RhoA and activates it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20721", "l": "H2O + isopenicillin N + phenylacetyl-CoA => CoA + H(+) + L-2-aminoadipate + penicillin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13531", "l": "H2O + mesaconate => (3S)-citramalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72923", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40245", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71615", "l": "(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34494", "l": "H2O + UDP-N,N'-diacetylbacillosamine <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60043", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate <=> (2E)-3-methylhex-2-enoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0072544", "l": "L-DOPA binding", "d": ["Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13141", "l": "2-methylpropanoyl-CoA = butanoyl-CoA", "d": [], "t": []}, {"i": "EC:5.4.99.13", "l": "\"isobutyryl-CoA mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24845", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O => 2 isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012835", "l": "GDIs block activation of RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080079", "l": "cellobiose glucosidase activity", "d": ["Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26060", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine => methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11829", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33826", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH <=> NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975594", "l": "PLB1 hydrolyses RPALM to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62544", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin = dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58025", "l": "oleanolate + UDP-alpha-D-glucose => H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12632", "l": "2-oxoglutarate + L-hyoscyamine + O2 <=> (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047359", "l": "1-alkenyl-2-acylglycerol choline phosphotransferase activity", "d": ["Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.50", "l": "\"V-cath endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29762", "l": "octanoate(in) <=> octanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.24", "l": "\"gelatinase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683772", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35901", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051408", "l": "glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11565", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate => alpha-D-glucose 1-phosphate + D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202212", "l": "Recruitment of PLC-gamma1 to LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65156", "l": "2-oxoglutarate + O2 + preaustinoid A2 = CO2 + H2O + preaustinoid A3 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14936", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12867", "l": "1-methyladenine + D-ribose => 1-methyladenosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.34", "l": "\"acyl-lipid (9+3)-(E)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849094", "l": "ARHGAP35 binds RASA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61984", "l": "H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40023", "l": "9alpha-copalyl diphosphate + H2O = diphosphate + syn-copalol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58644", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46309", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629499", "l": "NEIL3 cleaves thymine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351894", "l": "Caspase mediated cleavage of BAP31 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76926", "l": "2-methylcyclopentanamine + H2O + NADP(+) <=> 2-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18411", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46461", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419049", "l": "ROCK activation by RHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39259", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA = (2E,13Z)-docosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57430", "l": "formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol => anisole + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800315", "l": "MST1 binds MST1R (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34673", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43633", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) => an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19830", "l": "a primary alcohol + O2 => an aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004603", "l": "phenylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41533", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369052", "l": "ABCAs mediate lipid influx (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140806", "l": "SERPINC1 binds SERPINC1 activators (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047140", "l": "glutathione-CoA-glutathione transhydrogenase activity", "d": ["Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11750", "l": "4-fluoro-L-threonine + acetaldehyde => fluoroacetaldehyde + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20951", "l": "3-sulfopyruvate + H(+) <=> CO2 + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197963", "l": "DHFR2 reduces FOLA to DHF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399982", "l": "AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33129", "l": "beta-D-glucose 6-phosphate + salicyl alcohol => H2O + salicin-6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62986", "l": "hexadecanoate + NH4(+) => H2O + hexadecanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15487", "l": "cis-homoaconitate + H2O => (2R,3S)-homoisocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47861", "l": "a ganglioside GT1b (d18:1(4E)) + H2O => a ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49502", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71050", "l": "Trimerization of the FASL:FAS receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42238", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14554", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate => 2-oxoglutarate + cephalosporin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17249", "l": "2 Fe(2+) + 2 H2O + H2O2 = 6 H(+) + 2 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20946", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41556", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.47", "l": "\"[50S ribosomal protein L16]-arginine 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46432", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.38", "l": "\"FMN reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851933", "l": "MET phosphorylates GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62114", "l": "H2O + iminosuccinate => (3S)-3-hydroxy-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11839", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16013", "l": "ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)", "d": [], "t": []}, {"i": "EC:6.1.1.14", "l": "\"glycine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75595", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16070", "l": "cytidine + H(+) + H2O => NH4(+) + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371435", "l": "Constitutive phosphorylation by GSK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17793", "l": "H2O + L-alanyl-tRNA(Thr) = H(+) + L-alanine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61686", "l": "glycerol + H(+) + phosphocholine => glycero-2-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140670", "l": "cohesin unloader activity", "d": ["Facilitating a conformational change to unload a cohesin complex from sister chromatids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297444", "l": "Binding of cAMP to HCN channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606287", "l": "RSF complex binds the centromere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698029", "l": "p-STAT5 dissociates from mutant FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77367", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + CMP-N-acetyl-beta-neuraminate = [N-acetyl-alpha-D-neuraminosyl-(2->8)](n+1) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26295", "l": "1'-hydroxyversicolorone + H2O + NADP(+) => (1'S,5'S)-averufin + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57946", "l": "CO2 + 2 H2O + heme b => H(+) + H2O2 + harderoheme III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51465", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.41", "l": "\"pullulanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809680", "l": "MTMR12 binds MTM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61746", "l": "stevioside + UDP => steviolbioside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44943", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65942", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611839", "l": "β3-agonists bind ADRB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994148", "l": "LRRC16A binds F-actin capping protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140769", "l": "factor VII -> factor VIIa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22366", "l": "3-dehydroquinate + H(+) + NADH => L-quinate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19150", "l": "L-arginyl-[protein] + NAD(+) => H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004160", "l": "dihydroxy-acid dehydratase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53675", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047337", "l": "dolichyl-diphosphate-polyphosphate phosphotransferase activity", "d": ["Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13317", "l": "(2R,3R)-tartrate + H(+) = (R)-glycerate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.73", "l": "\"tartrate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39557", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.097525820927416", "identifiers": [{"i": "GO:0004674", "l": "protein serine/threonine kinase activity", "d": ["Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43161", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050555", "l": "2-hydroxypropyl-CoM lyase activity", "d": ["Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50529", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203712", "l": "eNOS associates with Caveolin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44132", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.128", "l": "\"N(4)-bis(aminopropyl)spermidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031370", "l": "eukaryotic initiation factor 4G binding", "d": ["Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994169", "l": "F-actin capping protein binds to the barbed end of elongating F-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72415", "l": "Li(+)(in) + Na(+)(out) = Li(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170674", "l": "Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59700", "l": "D-cellopentaono-1,5-lactone + H2O = D-cellopentaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56763", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76092", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13476", "l": "H2O + L-tryptophan + NAD(+) <=> H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102086", "l": "N-vanillate-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP = H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665121", "l": "ERBB2 KD mutants bind TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45482", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+) => gamma-hexachlorocyclohexane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17271", "l": "H(+) + S-adenosyl-L-homocysteine + tylosin => macrocin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60065", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45434", "l": "H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate => H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12500", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25879", "l": "L-aspartate + O2 <=> H2O2 + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047059", "l": "polyvinyl alcohol dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49460", "l": "(2Z,4E)-2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.11", "l": "\"2-aminomuconate deaminase (2-hydroxymuconate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50216", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383190", "l": "HCO3- transport through ion channel (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11477", "l": "glycerol 1-phosphate + H2O => glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3221982", "l": "BANP binds TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51792", "l": "H(+) + NADH + O2 + salicylate = 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029473", "l": "Branching and elongation of mother and daughter filaments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66340", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047568", "l": "3-oxo-5-beta-steroid 4-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52705", "l": "H2O + UMP => D-ribose 5-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48062", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029454", "l": "Autophosphorylation of PAK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10865", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 => 2-(acetamidomethylene)succinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624800", "l": "CDK1 phosphorylates LBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70427", "l": "H2O + phenylacetyl-CoA = 2-phenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50795", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374662", "l": "Translocation of Ezrin to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29769", "l": "ADP + D-methionine(in) + H(+) + phosphate => ATP + D-methionine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.69", "l": "\"8-oxo-(d)GTP phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45873", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814695", "l": "PERP binds desmosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33011", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.10", "l": "\"acrosin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102098", "l": "D-galacturonate reductase activity", "d": ["Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51591", "l": "isopyridoxal + NAD(+) <=> 5-pyridoxolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21127", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61913", "l": "ATP + H2O + voriconazole(in) => ADP + H(+) + phosphate + voriconazole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14147", "l": "ADP + H(+) + phosphoguanidinoacetate => ATP + guanidinoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54108", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + guaia-4,6-diene", "d": [], "t": []}, {"i": "EC:4.2.3.179", "l": "\"guaia-4,6-diene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044318", "l": "L-aspartate:fumarate oxidoreductase activity", "d": ["Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710353", "l": "GSDMD (1-275) binds cardiolipin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37255", "l": "A + D-asparagine + H2O = 2-oxosuccinamate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018680", "l": "deethylatrazine monooxygenase activity", "d": ["Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.271", "l": "\"crocetin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73089", "l": "AMP(in) + FAD(out) => AMP(out) + FAD(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190245", "l": "FGFR1b binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67356", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA = (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213207", "l": "Formation of collagen networks (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72300", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) => 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11136", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.3", "l": "\"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76127", "l": "3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44727", "l": "2,3-saturated fatty aldehyde + NADP(+) <=> (2E)-fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.-", "l": "\"Aminopeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682769", "l": "LGI2 binds ADAM22,23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74715", "l": "Autophosphorylation of insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31279", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389919", "l": "Grb2 binds pBTLA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38085", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73867", "l": "serotonin(out) = serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25373", "l": "3-(1-carboxyvinyloxy)anthranilate + FMNH2 => (2S)-2-amino-4-deoxychorismate + FMN", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69299", "l": "CDT1 binds geminin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114361", "l": "SMAC binds XIAP within apoptosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68167", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36560", "l": "A + cis-4-hydroxy-D-proline => 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31269", "l": "6-oxohexanoate + H(+) + NADPH => 6-hydroxyhexanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975633", "l": "atROL binds to RBP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51047", "l": "indole-3-pyruvate imine dimer <=> CO2 + NH4(+) + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77111", "l": "1D-myo-inositol 1,2,3,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71432", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210274", "l": "SIRP beta binds TYROBP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23431", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49846", "l": "(-)-dehydrodiconiferyl acid ketone + a quinol => (-)-dehydrodiconiferyl acid + a quinone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69598", "l": "adenosine + IMP => AMP + inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730858", "l": "Autophosphorylation of BTK/ITK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647660", "l": "GSDME (1-270) binds PIPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44435", "l": "2 a 1-acylglycerol <=> a 1,2-diacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62554", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP => beta-D-glucosylceramide + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035639", "l": "purine ribonucleoside triphosphate binding", "d": ["Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879459", "l": "F-actin capping protein is a heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72374", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) <=> dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20610", "l": "2-dehydro-3-deoxy-D-arabinonate => glycolaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655270", "l": "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11822", "l": "H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide => diphthamide-[translation elongation factor 2] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0050734", "l": "hydroxycinnamoyltransferase activity", "d": ["Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74469", "l": "a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73958", "l": "3,4-dihydroxystyrene + H(+) + NADH <=> 4-ethylcatechol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38068", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37065", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59521", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008695", "l": "3-phenylpropionate dioxygenase activity", "d": ["Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22704", "l": "2 H2O + ricinine = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.5.2", "l": "\"ricinine nitrilase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12580", "l": "H2O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine", "d": [], "t": []}, {"i": "EC:1.5.1.23", "l": "\"tauropine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58988", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 = (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49582", "l": "cyclic pyranopterin phosphate + diphosphate => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186773", "l": "PDGF dimer binds two receptors simultaneously (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12873", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) = 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44560", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate = 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005292", "l": "high-affinity lysine transmembrane transporter activity", "d": ["Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21709", "l": "H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17241", "l": "an alpha-amino acid ester + H2O = an alcohol + an alpha-amino acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.43", "l": "\"alpha-amino-acid esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55641", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164500", "l": "Conformational changes in gp120 exposes gp41 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391936", "l": "EP1 receptor can bind PGE2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76659", "l": "butanal + H2O + NADP(+) = butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18927", "l": "D-glucurono-3,6-lactone + H(+) + NADPH => L-gulono-1,4-lactone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16632", "l": "(S)-malyl-CoA <=> acetyl-CoA + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60053", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050638", "l": "taxadien-5-alpha-ol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1629787", "l": "Synthesis of Cx26 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183052", "l": "CBL binds to GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43966", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17528", "l": "biuret + H2O <=> NH4(+) + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73480", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) => D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60471", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76759", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,5-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749197", "l": "ORC1 binds to H4K20me2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194808", "l": "botF LC cleaves target cell VAMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19276", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate <=> N-acetylneuraminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17245", "l": "3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": [], "t": []}, {"i": "EC:1.10.3.5", "l": "\"3-hydroxyanthranilate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12612", "l": "mercaptopurine + S-adenosyl-L-methionine <=> 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797554", "l": "ABP1 binds SHANK proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35362", "l": "3-hydroxyisoheptadecanoyl-CoA <=> (2E)-15-methylhexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381727", "l": "RAP1A exchanges GDP for GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034903", "l": "endosulfan ether monooxygenase activity", "d": ["Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45458", "l": "dodecanoate + ethanolamine => H2O + N-dodecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47443", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) <=> 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38333", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639567", "l": "NPAS4 gene transcription is repressed by KCNIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60875", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12640", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13078", "l": "an acyl phosphate + D-hexose => a carboxylate + D-hexose phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.182", "l": "\"taxoid 7beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28213", "l": "H2O + L-saccharopine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36582", "l": "dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59871", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine <=> 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33881", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH => 2-deoxy-scyllo-inosamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21935", "l": "S-adenosyl-L-methionine <=> L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59090", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => D-histidine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76702", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45332", "l": "7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.81", "l": "\"7,8-dihydroneopterin oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.1", "l": "\"asparaginase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140417", "l": "ATP-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72151", "l": "estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050221", "l": "prostaglandin-E2 9-reductase activity", "d": ["Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158357", "l": "factor XIIa binds SERPING1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433374", "l": "Processing of SCF isoform 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072590", "l": "N-acetyl-L-aspartate-L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate."], "t": []}, {"i": "REACT:R-HSA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59146", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate => 10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50812", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35157", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one => (S)-4,5-dihydroxypentane-2,3-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59069", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine => deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980123", "l": "DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69350", "l": "(E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate => S-1-propenyl-L-cysteine sulfoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218806", "l": "FYN autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39208", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928624", "l": "EPHBs bind EFNBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32410", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37971", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.19.n4", "l": "\"stearoyl-CoA 9-desaturase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31317", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24022", "l": "fumarate + L-arginine => 2-(N(omega)-L-arginino)succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51316", "l": "(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50764", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48121", "l": "a ganglioside GD3 + H2O => a ganglioside GM3 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55850", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.2", "l": "\"glucokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72268", "l": "chloride(out) + formate(in) => chloride(in) + formate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16755", "l": "3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+) => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35303", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) = 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54114", "l": "diphosphate + selina-4(15),7(11)-diene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52439", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39797", "l": "7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate => 7beta-hydroxycholesterol(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40779", "l": "2-aminopentanenitrile + H(+) + 2 H2O = L-2-aminopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12480", "l": "5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.43", "l": "\"aminolevulinate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852552", "l": "MST1R autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75589", "l": "erinacine Q2 + H(+) + UDP => 11-O-acetylcyathatriol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.5.1.-", "l": "\"Carbon-halide lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671993", "l": "CIT-3 binds DLG4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27951", "l": "L-phenylalanine(in) => L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687107", "l": "MAPK4,6 translocate to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47591", "l": "a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716913", "l": "ESR1 binds ESR1 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034834", "l": "2-mercaptobenzothiazole dioxygenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34680", "l": "ATP + methylphosphonate => adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804379", "l": "PRMT5 binds TTC5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58147", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) <=> AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134954", "l": "DHX9 binds DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140952", "l": "histone H3K27 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75289", "l": "glyoxylate(out) + sulfate(in) => glyoxylate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47975", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41554", "l": "diphosphate + ophiobolin F => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0052744", "l": "phosphatidylinositol monophosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050066", "l": "lysine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27916", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676161", "l": "PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52335", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] <=> 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012087", "l": "Autocatalytic phosphorylation of FGFR4 Y367C mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28563", "l": "D-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0015407", "l": "ABC-type monosaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15211", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3R)-tartrate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51039", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> 2 H2O + indole-3-pyruvate imine dimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23293", "l": "ATP + L-lombricine => ADP + H(+) + N-phospho-L-lombricine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325546", "l": "Defective CD320 does not transport extracellular TCII:Cbl to endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62592", "l": "(S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17536", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173642", "l": "Disintegration of matrix layer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4837364", "l": "Secretion of SOD3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001639", "l": "PLC activating G protein-coupled glutamate receptor activity", "d": ["A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050317", "l": "tagatose kinase activity", "d": ["Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16184", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15990", "l": "(R)-mevalonate + CoA + 2 NADP(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0016884", "l": "carbon-nitrogen ligase activity, with glutamine as amido-N-donor", "d": ["Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen."], "t": []}, {"i": "EC:6.3.5.-", "l": "\"Carbon--nitrogen ligases with glutamine as amido-N-donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38779", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35573", "l": "(1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726509", "l": "NR3C2 binds fludrocortisone (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52644", "l": "D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030751", "l": "licodione 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75835", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione = (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725206", "l": "IgE binds FCERI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205321", "l": "Interaction of KIT and sSCF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "52.631795878319934", "identifiers": [{"i": "GO:0140096", "l": "catalytic activity, acting on a protein", "d": ["Catalytic activity that acts to modify a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77170", "l": "AH2 + hercynyl-SeGlcNAc selenoxide <=> 2-acetamidoglucal + A + H2O + selenoneine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35302", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874979", "l": "ACBD3 binds GOLGB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11000", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O = a D-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.77", "l": "\"N-carbamoyl-D-amino-acid hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51554", "l": "H(+) + L-xylo-3-hexulose + NADPH => D-sorbitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33938", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16369", "l": "(R)-lactate + NAD(+) = H(+) + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.1.28", "l": "\"D-lactate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44799", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine <=> H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75687", "l": "ATP(in) = ATP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69196", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-167415", "l": "G-protein alpha subunit is inactivated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65164", "l": "benzoyl-CoA + hexan-3-ol = CoA + hexan-3-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046565", "l": "3-dehydroshikimate dehydratase activity", "d": ["Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47743", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate <=> CO2 + demethylphylloquinone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65295", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate <=> 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004319", "l": "enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31223", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O = beta-D-glucose + cis-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46511", "l": "NADH + nitrobenzene + O2 <=> catechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018581", "l": "hydroxyquinol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726875", "l": "HCNs:cAMP bind SNIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682020", "l": "MRN complex binds shortened telomeres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61563", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928627", "l": "EPHB phosphorylates TIAM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44778", "l": "H(+) + menaquinol-6 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-6 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17430", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate => 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61474", "l": "an N-hexadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25980", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102593", "l": "UDP-glucose: N-methylanthranilate glucosyltransferase activity", "d": ["Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989759", "l": "Expression of G0S2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22237", "l": "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44657", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706330", "l": "Active FLT3 binds to SOCS6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55532", "l": "H(+) + H2O + L-phenylalanine + O2 = 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:4.1.1.109", "l": "\"phenylacetaldehyde synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264622", "l": "Cho is acetylated to AcCho by CHAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.57", "l": "\"isopullulanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990593", "l": "nascent polypeptide-associated complex binding", "d": ["Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13582", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69160", "l": "agmatine + H2O + O2 = H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654603", "l": "Activated FGFR2 binds FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45512", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68296", "l": "dodecanoyl-CoA + L-seryl-[protein] = CoA + O-dodecanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036383", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43987", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706350", "l": "FLT3 phosphorylates CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749609", "l": "BCHE hydrolyzes ASA- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14391", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12379", "l": "ATP + L-fuculose <=> ADP + H(+) + L-fuculose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32330", "l": "10-hydroxy-alpha-humulene + NAD(+) <=> H(+) + NADH + zerumbone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19184", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3899291", "l": "SUMOylation of EP300 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55934", "l": "AMP + H(+) + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58911", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034576", "l": "N-isopropylacetanilide amidohydrolase activity", "d": ["Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63351", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] <=> (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29292", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77440", "l": "a ganglioside GQ1c + H2O => a ganglioside GT1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221982", "l": "BANP binds TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29886", "l": "ATP + H2O + L-ornithine(out) <=> ADP + H(+) + L-ornithine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825340", "l": "N protein coats hRSV genomic (-)ssRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858475", "l": "ppDVL recruits RAC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12230", "l": "AMP + diphosphate + H(+) + L-asparagine + L-glutamate => ATP + H2O + L-aspartate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43390", "l": "1D-myo-inositol 3-phosphate + phosphate => 1D-myo-inositol 3,4-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198270", "l": "PDPK1 phosphorylates AKT at T308 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28791", "l": "5,6-dihydrothymine + NAD(+) = H(+) + NADH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009309", "l": "RUNX2 binds STUB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003851", "l": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.40", "l": "\"phytepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55759", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 <=> a 2-hydroxyornithine lipid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17905", "l": "(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047032", "l": "3-alpha-hydroxyglycyrrhetinate dehydrogenase activity", "d": ["Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74232", "l": "H2O + L-threonyl-tRNA(Val) => L-threonine + tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186780", "l": "Degradation of Ub-SMAD7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111237", "l": "Formation of ADAR1 homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74780", "l": "laricitrin + S-adenosyl-L-methionine => 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013004", "l": "RHOA binds effectors at the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877192", "l": "RUNX1 binds FOXP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50840", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51354", "l": "(9Z)-octadecenoate + L-serine => H2O + N-(9Z-octadecenoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70609", "l": "4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-ethylphenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59275", "l": "L-cysteine <=> D-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341294", "l": "Superoxide reduces cytochrome c (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0004707", "l": "MAP kinase activity", "d": ["Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70573", "l": "argininosuccinate <=> fumarate + arginine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51625", "l": "formate + GTP + H(+) => CO2 + dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73041", "l": "H(+)(in) + Ni(2+)(in) => H(+)(out) + Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23384", "l": "D-cellobiose = beta-D-glucosyl-(1->4)-D-mannopyranose", "d": [], "t": []}, {"i": "EC:5.1.3.11", "l": "\"cellobiose epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31719", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000100", "l": "S-methylmethionine transmembrane transporter activity", "d": ["Enables the transfer of S-methylmethionine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036729", "l": "Defective GAA does not hydrolyze lysosomal glycogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164381", "l": "G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21325", "l": "2 H(+) + reduced [rubredoxin] + superoxide => H2O2 + oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351849", "l": "Caspase-mediated cleavage of Etk (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62546", "l": "dihydroouabagenin + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805546", "l": "Keratin type I binds keratin type II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19525", "l": "(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.13", "l": "\"(+)-delta-cadinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55277", "l": "9-cis-retinol + tetradecanoyl-CoA => 9-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140605", "l": "proton motive force-driven motor activity", "d": ["A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545196", "l": "FN1 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13693", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.19", "l": "\"trimethylsulfonium--tetrahydrofolate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.182", "l": "\"lipid-A-disaccharide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678925", "l": "NR3C1 binds NR3C1 agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047420", "l": "N-acyl-D-amino-acid deacylase activity", "d": ["Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140867", "l": "NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-18 residue of histone H2B (or an equivalent residue)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10555", "l": "D-glucose + O2 <=> 2-dehydro-D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35485", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266557", "l": "Factor I cleaves iC3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67832", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912627", "l": "CBL ubiquitinates PI3K (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68772", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.5", "l": "\"exodeoxyribonuclease V\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63022", "l": "(9Z,12Z)-octadecadienoate + NH4(+) => (9Z,12Z)-octadecadienamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72663", "l": "De novo formation of eIF2:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73566", "l": "dGDP(out) + UTP(in) <=> dGDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16497", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.181", "l": "\"23S rRNA (adenine(1618)-N(6))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016594", "l": "glycine binding", "d": ["Binding to glycine, aminoethanoic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56178", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+) => 8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29676", "l": "glycerol(in) => glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66328", "l": "taurine(out) = taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297354", "l": "Acrosin Cleavage (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46962", "l": "(2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429815", "l": "Formation Of Bloc-1 Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49463", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177922", "l": "EGFR dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39844", "l": "a 1,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58267", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12766", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76349", "l": "(2R,3S)-3-isopropylmalate(out) + sulfate(in) => (2R,3S)-3-isopropylmalate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60434", "l": "AH2 + cannabichromenate => A + cannabigerolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64790", "l": "(E)-cinnamoyl-CoA + AMP + diphosphate => (E)-cinnamate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53296", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61260", "l": "H2O + L-glutamine + O2 = 2-oxoglutaramate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58771", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73932", "l": "Resynthesis of excised residue by POLB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27526", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate", "d": [], "t": []}, {"i": "EC:3.1.7.6", "l": "\"farnesyl diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71953", "l": "3 Na(+)(in) + sulfate(in) => 3 Na(+)(out) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22510", "l": "diphosphate + DNA(n+1) => a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70643", "l": "D-proline(out) + H(+)(out) = D-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209891", "l": "Dopamine is oxidised to noradrenaline (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12324", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = L-asparagine + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:3.2.2.11", "l": "\"beta-aspartyl-N-acetylglucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26408", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) <=> H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75772", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O => (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68127", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] <=> a triacylglycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.25", "l": "\"glycyl endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.12", "l": "\"cGMP-dependent protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.29", "l": "\"sulfinoalanine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37532", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53103", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42832", "l": "(2E)-octenal + H(+) + pyruvate = (S)-3-acetyloctanal + CO2", "d": [], "t": []}, {"i": "EC:2.2.1.12", "l": "\"3-acetyloctanal synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138432", "l": "DVL2 is phosphorylated by PKC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13304", "l": "a 1,2-diacyl-sn-glycerol + a sterol <=> a 1-acyl-sn-glycerol + a sterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72655", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 = 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019782", "l": "ISG15 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32774", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate <=> 2,6-dioxo-6-phenylhexa-3-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015141", "l": "succinate transmembrane transporter activity", "d": ["Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55663", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 <=> 2 A + echinenone + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11159", "l": "H2O + L-valine + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73517", "l": "UDP(in) + UTP(out) => UDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73960", "l": "2-methoxy-4-vinylphenol + H(+) + NADH => 4-ethyl-2-methoxyphenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40408", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.108", "l": "\"protein adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951727", "l": "cAMP binds PKA tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76870", "l": "(R)-1-phenylethylamine + H2O + NAD(+) <=> acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67532", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102707", "l": "S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66743", "l": "ATP + H2O + N-acetyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75891", "l": "Abortive Initiation After Second Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047699", "l": "beta-diketone hydrolase activity", "d": ["Catalysis of the reaction: H2O + nonane-4,6-dione = butanoate + H+ + pentan-2-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69573", "l": "dIMP + inosine => 2'-deoxyinosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.19", "l": "\"C-19 steroid 1alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004826", "l": "phenylalanine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529020", "l": "CK2 phosphorylates condensin I subunits (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58099", "l": "1-tetracosanoylglycerol + H2O <=> glycerol + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50702", "l": "calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0008188", "l": "neuropeptide receptor activity", "d": ["Combining with a neuropeptide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41908", "l": "(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68046", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.-", "l": "\"Methyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66462", "l": "14betaH-scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25160", "l": "2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23162", "l": "L-rhamnulose => L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45006", "l": "CoA + O-2,6-dimethylheptanoyl-(R)-carnitine => (R)-carnitine + 2,6-dimethylheptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684350", "l": "pp1a forms a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947499", "l": "Exchange of oxygen with sulfur in MoCo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12372", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.45", "l": "\"carboxymethylenebutenolidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31358", "l": "dimethyl sulfide + H(+) + NADH + O2 <=> formaldehyde + H2O + methanethiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32427", "l": "(1R,4S)-isodihydrocarvone + A = (S)-carvone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19984", "l": "NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11527", "l": "5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68670", "l": "16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53810", "l": "(24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445085", "l": "Phosphorylation of VAV2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62740", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32522", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine <=> (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52537", "l": "adenosine + dGTP => AMP + dGDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022141", "l": "Prolysyl oxidase activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688834", "l": "ATXN3 binds VCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69116", "l": "Formation of Okazaki fragments (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45071", "l": "(R)-carnitine + an acyl-CoA <=> CoA + O-acyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071209", "l": "U7 snRNA binding", "d": ["Binding to a U7 small nuclear RNA (U7 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26243", "l": "diphosphate + elisabethatriene => geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32707", "l": "(2E)-geranyl diphosphate = (2R,4S)-bornyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.22", "l": "\"(-)-bornyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41597", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH => (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424476", "l": "Activation of RAC1 by VAV2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714580", "l": "SLC6A3 binds DRIs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32951", "l": "sucrose = trehalulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.43", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24182", "l": "CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32352", "l": "3 S-adenosyl-L-methionine + tricetin => 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612593", "l": "ERBB4 binds DLG4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33400", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) => L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28431", "l": "D-allose 6-phosphate => D-allulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432464", "l": "Phosphorylated TIM:PER heterodimer dissociate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004534", "l": "5'-3' RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429157", "l": "ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54484", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473184", "l": "Follistatin (FST) binds Activin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848726", "l": "PTK6 phosphorylates BCAR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15337", "l": "H2O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate", "d": [], "t": []}, {"i": "EC:3.1.2.25", "l": "\"phenylacetyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213208", "l": "Type X collagen associates with collagen type II fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17138", "l": "prostaglandin H2 => thromboxane A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11475", "l": "an N-methyl-L-amino acid + H2O + O2 <=> an L-alpha-amino acid + formaldehyde + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662606", "l": "MT3 binds zinc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11970", "l": "7,8-dihydro-7,8-dihydroxykynurenate + A => AH2 + kynurenate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14408", "l": "D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796626", "l": "MIB2 ubiquitinates CFLAR  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036143", "l": "kringle domain binding", "d": ["Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14446", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75481", "l": "S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out) => S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21855", "l": "(R)-10-hydroxyoctadecanoate <=> (9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15399", "l": "2 chloride + formaldehyde + 2 H(+) => dichloromethane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73944", "l": "dehydrogriseofulvin + H(+) + NADPH => griseofulvin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56442", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001077", "l": "(1->3),(1->4)-beta-glucan binding", "d": ["Binding to (1->3),(1->4)-beta-glucan."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47983", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41740", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.219", "l": "\"tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798748", "l": "Exocytosis of secretory granule lumen proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449687", "l": "Corticosteroids bind to CBG in blood (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23596", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": [], "t": []}, {"i": "EC:1.1.1.22", "l": "\"UDP-glucose 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.73", "l": "\"inosine/xanthosine triphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77449", "l": "(2S)-2-hydroxy-2-(4-methoxyphenyl)acetonitrile => 4-methoxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010292", "l": "GTP:GDP antiporter activity", "d": ["Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032137", "l": "guanine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a G/T mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57475", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.350", "l": "\"ureidoglycolate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662851", "l": "Defective DCXR does not reduce L-xylulose to xylitol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27484", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692315", "l": "OX40L binds OX40 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67365", "l": "H2O + L-threonyl-L-serine => L-serine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612509", "l": "SGK phosphorylates SRF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17749", "l": "A + H2O + quinoline = AH2 + quinolin-2(1H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647994", "l": "RAS proteins are depalmitoylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64198", "l": "a fatty acid + L-lysine => an N-(fatty acyl)-L-lysine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59309", "l": "D-galactono-1,5-lactone + H2O => D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54175", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69667", "l": "H2O + luteolin 4'-O-beta-D-glucoside = beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47377", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62414", "l": "acetyl-CoA + vanillin => (E)-feruloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061503", "l": "tRNA threonylcarbamoyladenosine dehydratase", "d": ["Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140953", "l": "histone H3K27 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695415", "l": "glycosylated-ACE2 binds ACE2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10087", "l": "3,4-dihydroxybenzoate + O2 <=> 3-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802837", "l": "Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.44", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71764", "l": "2-oxoglutarate(out) + citrate(in) => 2-oxoglutarate(in) + citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75804", "l": "butanoate(out) + Na(+)(out) => butanoate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43441", "l": "hexadecanoate + sphinganine => H2O + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15711", "l": "H(+) + kaempferol 3-O-beta-D-galactoside + UDP => kaempferol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047143", "l": "chlorate reductase activity", "d": ["Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14089", "l": "2-oxoglutarate + glycine = glyoxylate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.4", "l": "\"glycine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12270", "l": "1-pyrroline + H2O + L-glutamate => 2-oxoglutarate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377644", "l": "Release of CSK from SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866854", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419645", "l": "Dimerization of LIMK1 by Hsp90 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787820", "l": "IL34 dimer binds CSF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708557", "l": "FBXL17 binds BACH1:MAFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64887", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67059", "l": "chermesin D + S-adenosyl-L-methionine <=> chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11407", "l": "UDP-alpha-D-glucuronate <=> UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72890", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] <=> ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388832", "l": "PI3K binds CD28 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35584", "l": "2-dehydro-3-deoxy-D-gluconate => D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10084", "l": "3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.3", "l": "\"protocatechuate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49600", "l": "ATP + CoA + octanedioate = AMP + diphosphate + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399941", "l": "AKT1 E17K mutant phosphorylates BAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047436", "l": "arylmalonate decarboxylase activity", "d": ["Catalysis of the reaction: 2-aryl-2-methylmalonate + H+ = 2-arylpropionate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836275", "l": "TFAP2A binds TFAP2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69062", "l": "H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+) => N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65835", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019982", "l": "interleukin-7 binding", "d": ["Binding to interleukin-7."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019153", "l": "protein-disulfide reductase (glutathione) activity", "d": ["Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952081", "l": "RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69330", "l": "5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004306", "l": "ethanolamine-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71436", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) => an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044535", "l": "very-long-chain fatty acyl-CoA oxidase activity", "d": ["Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102669", "l": "isoflavone-7-O-glucoside beta-glucosidase activity", "d": ["Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O = daidzein + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445699", "l": "ATP Hydrolysis By Myosin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932284", "l": "PKC phosphorylates NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850534", "l": "PDCL promotes G-protein beta 5 folding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24591", "l": "ATP + D-arabinose <=> ADP + D-arabinose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617595", "l": "SGTA binds mislocalized membrane protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52899", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16254", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) => H(+) + NADH + phenanthrene-3,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19423", "l": "(R)-1,2-epoxypropane + coenzyme M => (R)-2-hydroxypropyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67432", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770063", "l": "S1,S2 Dissociate from S1:ACE2:S2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68507", "l": "(2Z,6Z)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730872", "l": "Activation of Calcineurin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664850", "l": "ATM binds PEX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71909", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide => GDP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71269", "l": "chloride(in) + L-pipecolate(in) + 2 Na(+)(in) => chloride(out) + L-pipecolate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110307", "l": "REV1 binds AP-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57354", "l": "H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391939", "l": "TP receptor can bind thromboxane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37736", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27873", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36485", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389381", "l": "Gads binds CD28 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873794", "l": "PCTP binds PC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46164", "l": "a quinone + H(+) + NADPH = a quinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61489", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13162", "l": "L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69634", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633044", "l": "ESR binds STRN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218642", "l": "PTK2 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74225", "l": "L-serine + tRNA(Ala) => H2O + L-seryl-tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500804", "l": "Peroxynitrite is reduced by AhpE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22924", "l": "dCMP + H(+) + H2O = dUMP + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.12", "l": "\"dCMP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45897", "l": "an N-acyl-sphingoid base + CDP-ethanolamine => an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.170170386724372", "identifiers": [{"i": "GO:0017111", "l": "ribonucleoside triphosphate phosphatase activity", "d": ["Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18180", "l": "a 2,3-saturated acyl-CoA + NAD(+) <=> a (2E)-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341048", "l": "SUMOylation of RXRA with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49975", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76835", "l": "ethylamine + H2O + NAD(+) = acetaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65722", "l": "butanal + CO2 + H(+) + succinate + sulfate => 2-oxoglutarate + butyl sulfate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809309", "l": "MTMR6 binds MTMR9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295632", "l": "PPA2A dephosphorylates SPRY2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202248", "l": "Phosphorylation of PLC-gamma1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807872", "l": "Active ARF recruits coatomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74528", "l": "H(+) + N(6),N(6)-dimethyl-L-lysine => CO2 + N,N-dimethyl-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62735", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48019", "l": "4-methyl-5-nitrocatechol + NADH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76371", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102917", "l": "(S)-reticuline 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine = H+ + laudanine(1+) + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43155", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015229", "l": "L-ascorbic acid transmembrane transporter activity", "d": ["Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species."], "t": []}, {"i": "REACT:R-HSA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15795", "l": "biliverdin IXalpha + H(+) + NADPH => bilirubin IXalpha + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140835", "l": "RNA polymerase II CTD heptapeptide repeat T4 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphothreonine (position 4)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375384", "l": "Bombesin-like receptors bind bombesin homologues (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53572", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23996", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16838", "l": "5'-acylphosphoadenosine + H2O => a carboxylate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014834", "l": "ROBO1,ROBO2 bind SLIT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14001", "l": "choloyl-CoA + glycine = CoA + glycocholate + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.65", "l": "\"bile acid-CoA:amino acid N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794444", "l": "ALB binds Cipro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32512", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27934", "l": "(3S)-3-hydroxy-D-aspartate = glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15749", "l": "(S)-mandelate + A = AH2 + phenylglyoxylate", "d": [], "t": []}, {"i": "EC:1.1.99.31", "l": "\"(S)-mandelate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28174", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25069", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034024", "l": "glutamate-putrescine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106258", "l": "L-serine-phosphatidylcholine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline."], "t": []}, {"i": "RHEA:45088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30865", "l": "L-tyrosine + phosphate => 4-O-phospho-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791108", "l": "Expression of SULT1A3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32236", "l": "(6S)-NADPHX + ADP => AMP + H(+) + NADPH + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72373", "l": "dehydroepiandrosterone 3-sulfate(in) + succinate(out) => dehydroepiandrosterone 3-sulfate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36397", "l": "7-dehydrodesmosterol + H(+) + NADPH => 7-dehydrocholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132264", "l": "Formation of alternate C5 convertase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23172", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371582", "l": "HSBP1 binds HSF1 trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388829", "l": "SHP2 phosphatase binds CTLA-4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49480", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) = H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75265", "l": "3'-dehydroisovitexin + H2O2 => isovitexin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69594", "l": "cytidine + IMP => CMP + inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168423", "l": "JAK2 phosphorylation of IRS-1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20281", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate = (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19720", "l": "H(+) + L-phenylalanine <=> 2-phenylethylamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15885", "l": "NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.55", "l": "\"lactaldehyde reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56134", "l": "a thymidine dimer in DNA => (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0009784", "l": "transmembrane receptor histidine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17678", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O => 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58909", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH => C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45135", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53383", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) <=> H(+) + NADH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.-", "l": "\"Other intramolecular oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31511", "l": "chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13219", "l": "2 H(+) + NADH + succinate => H2O + NAD(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215144", "l": "TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050578", "l": "(R)-2-hydroxyacid dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50085", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) => ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936851", "l": "AHRR binds ARNT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20459", "l": "D-arabinono-1,4-lactone + H(+) + NADH => D-arabinose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15075", "l": "D-glucuronate + N(2),6-disulfo-D-glucosamine => 3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70712", "l": "D-alanine(in) => D-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004969", "l": "histamine receptor activity", "d": ["Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141439", "l": "Release of activated MAD2 from kinetochores (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29498", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> beta-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836702", "l": "PKR inhibitors bind PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75333", "l": "chloride(in) + D-methionine(in) + 2 Na(+)(in) => chloride(out) + D-methionine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57295", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O <=> a guanosine in RNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32967", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49398", "l": "20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70693", "l": "chloride(in) + glycine(in) + 2 Na(+)(in) => chloride(out) + glycine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21400", "l": "2-oxoglutarate + CoA + NADP(+) = CO2 + NADPH + succinyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.1.52", "l": "\"oxoglutarate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25532", "l": "ent-copalyl diphosphate = diphosphate + ent-cassa-12,15-diene", "d": [], "t": []}, {"i": "EC:4.2.3.28", "l": "\"ent-cassa-12,15-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13475", "l": "H(+) + indole-3-pyruvate + NADH + NH4(+) => H2O + L-tryptophan + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090422", "l": "thiamine pyrophosphate transmembrane transporter activity", "d": ["Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70234", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) <=> (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40736", "l": "(20S)-ginsenoside Rb1 + 2 H2O => 2 D-glucose + gypenoside LXXV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166220", "l": "FA anion diffuses laterally to UCP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28365", "l": "dGTP + H2O <=> dGMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25698", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64059", "l": "(1S,2R)-ephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40922", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17400", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46840", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76255", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16848", "l": "acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50607", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052687", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."], "t": []}, {"i": "KEGG.REACTION:R06396", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432946", "l": "PARVB/Affixin interacts with alpha PIX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004985", "l": "G protein-coupled opioid receptor activity", "d": ["Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17377", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617217", "l": "Phospho-CREB1 binds the promoter of the CEBPB gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58676", "l": "NADPH + O2 + rifamycin SV = H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180597", "l": "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9834807", "l": "ILF3 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59559", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone <=> H(+) + N,N'-diacetylchitobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.37", "l": "\"cis-2-enoyl-CoA reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671737", "l": "p-T774-PKN1 binds CDC25C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373015", "l": "citrate <=> isocitrate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32802", "l": "urea(in) <=> urea(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0034594", "l": "phosphatidylinositol trisphosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66127", "l": "2-oxobutanoate + L-histidine <=> (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60773", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 => 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.11", "l": "\"phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11231", "l": "(2S)-flavan-4-ol + NADP(+) <=> (2S)-flavanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16377", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.4", "l": "\"phytochromobilin:ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507868", "l": "Aquaporins passively transport water into cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047776", "l": "citramalate lyase activity", "d": ["Catalysis of the reaction: S-citramalate = acetate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75725", "l": "(10S)-hydroxy-(12Z)-octadecenoate => (9Z,12Z)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25158", "l": "AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + ATP + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008870", "l": "galactoside O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32571", "l": "(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.118", "l": "\"2-methylisoborneol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952232", "l": "BCL2L11 (BIM) gene transcription is stimulated by RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070404", "l": "NADH binding", "d": ["Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0050542", "l": "icosanoid binding", "d": ["Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46423", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66362", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40237", "l": "coenzyme M-coenzyme B heterodisulfide + succinate => coenzyme B + coenzyme M + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29146", "l": "a ubiquinol + 2 H(+)(in) + nitrate <=> a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74473", "l": "(Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate => (-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36572", "l": "sphinganine + tetradecanoyl-CoA => CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632182", "l": "PRMT1 methylates ESRs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450422", "l": "KSRP recruits RNA degradation activities (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005151", "l": "interleukin-1, type II receptor binding", "d": ["Binding to a Type II interleukin-1 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047423", "l": "N-methylhydantoinase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: N-methylhydantoin + ATP + 2 H2O = N-carbamoylsarcosine + ADP + 3 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928597", "l": "EPH:EFN dimers tetramerise (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376419", "l": "Formation of NR-MED1 Coactivator Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60816", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 = CO2 + gibberellin A14 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.166", "l": "\"3-deoxy-D-manno-octulosonic acid kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660665", "l": "Caspase-8 binds MALT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16730", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20123", "l": "AMP + diphosphate + L-glutaminyl-tRNA(Gln) => ATP + L-glutamine + tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19781", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.24", "l": "\"diiodotyrosine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42494", "l": "3'-N-debenzoyltaxol + A + H2O => 3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23499", "l": "5-hydroxypentanoate + acetyl-CoA <=> 5-hydroxy-pentanoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64928", "l": "dADP + H2O = dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625482", "l": "PTK2 binds activated EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15636", "l": "3,4-dihydroxyphenylacetate + O2 <=> 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30445", "l": "2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => 2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26012", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47089", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70751", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29124", "l": "nitrate(out) + ubiquinol-8(in) => H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102007", "l": "acyl-L-homoserine-lactone lactonohydrolase activity", "d": ["Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone = H+ + an N-acyl-L-homoserine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69693", "l": "a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP => a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609274", "l": "Active FLT3 binds HCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047296", "l": "homospermidine synthase activity", "d": ["Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759709", "l": "CNBP binds SARS-CoV-2 G-rich RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19084", "l": "1-haloalkane + H2O <=> a halide anion + a primary alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18333", "l": "ATP + oleandomycin = ADP + H(+) + oleandomycin 2'-O-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.136", "l": "\"macrolide 2'-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693540", "l": "MRN activates ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46130", "l": "4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32396", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003855", "l": "3-dehydroquinate dehydratase activity", "d": ["Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64675", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol <=> butyl 2-(methylsulfanyl)acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17476", "l": "GTP + H2O <=> 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166220", "l": "FA anion diffuses laterally to UCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017130", "l": "poly(C) RNA binding", "d": ["Binding to a sequence of cytosine residues in an RNA molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047763", "l": "caffeate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27974", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.99.3", "l": "\"7-carboxy-7-deazaguanine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15672", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015626", "l": "L-diaminopimelate transmembrane transporter activity", "d": ["Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70722", "l": "L-alanine(in) <=> L-alanine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40923", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18929", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.35", "l": "\"thiophene-2-carbonyl-CoA monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76753", "l": "delta-dodecalactone + H2O => 5-hydroxydodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32909", "l": "2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168376", "l": "STIM1 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20437", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.142", "l": "\"D-pinitol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28977", "l": "H(+)(in) + L-asparagine(out) => H(+)(out) + L-asparagine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29293", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate => (25S)-3-oxocholest-4-en-26-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222384", "l": "Glutathione scavenges nitrosyl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12513", "l": "D-aspartate + H2O + O2 => H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34486", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50734", "l": "(S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640321", "l": "2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226999", "l": "ADD1:ADD3 binds DMTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50628", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.139", "l": "\"pterocarpan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26509", "l": "(9Z)-octadecenamide + H2O <=> (9Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43756", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": [], "t": []}, {"i": "EC:2.3.1.266", "l": "\"[ribosomal protein bS18]-alanine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468040", "l": "Cohesin binds PDS5 and WAPAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26497", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031824", "l": "type 1E serotonin receptor binding", "d": ["Binding to a type 1E serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174058", "l": "Degradation of multiubiquitinated Cdh1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693243", "l": "RHOD translocates to the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033940", "l": "glucuronoarabinoxylan endo-1,4-beta-xylanase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809680", "l": "MTMR12 binds MTM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32548", "l": "(2E)-geranyl diphosphate => (1R,5R)-sabinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19989", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.23", "l": "\"S-methyl-5-thioribose-1-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40211", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) = 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833672", "l": "CDH11 forms heterotypic trans dimer with CDH8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60933", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088307", "l": "FOXM1 binds CCNB1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64418", "l": "D-xylono-1,4-lactone + H(+) + NADPH => D-xylofuranose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209921", "l": "Monoiodinated tyrosine can be deiodinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865275", "l": "PDGF-BB clevage by Furin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140769", "l": "factor VII -> factor VIIa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41124", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18382", "l": "dihydroxyacetone + phosphoenolpyruvate => dihydroxyacetone phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191299", "l": "Squalene is oxidized to its epoxide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44793", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine => H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55639", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49595", "l": "2-hydroxyisobutanoyl-CoA <=> (3S)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805811", "l": "Release of SEPT4 from mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67187", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine <=> (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56836", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:1.21.98.4", "l": "\"PqqA peptide cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43461", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097657", "l": "3',5'-nucleotide bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102695", "l": "UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + cis-zeatin-7-N-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350604", "l": "Agmatine + H2O <=> putrescine + urea (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001876", "l": "lipoarabinomannan binding", "d": ["Binding to lipoarabinomannan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912386", "l": "Ubiquitination of NOTCH1 by ITCH in the absence of ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176116", "l": "Recruitment and activation of Chk1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33890", "l": "(-)-secoisolariciresinol + 2 NAD(+) <=> (-)-matairesinol + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0141107", "l": "methyltransferase regulator activity", "d": ["Binds to and modulates the activity of a methyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848370", "l": "IL18 binds IL18R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77108", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40200", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019806", "l": "bromide peroxidase activity", "d": ["Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide."], "t": []}, {"i": "EC:1.11.1.18", "l": "\"bromide peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60137", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64909", "l": "CTP + 2 H2O => CMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0097603", "l": "temperature-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51969", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13103", "l": "H2O + trans-urocanate => 4-imidazolone-5-propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38683", "l": "ATP + H2O + sphing-4-enine(in) = ADP + H(+) + phosphate + sphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700175", "l": "Active ALK phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031895", "l": "V1B vasopressin receptor binding", "d": ["Binding to a V1B vasopressin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.691787587221924", "identifiers": [{"i": "GO:0016627", "l": "oxidoreductase activity, acting on the CH-CH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1170539", "l": "Prolactin receptor is internalized (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52224", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 = 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016501", "l": "prostacyclin receptor activity", "d": ["Combining with prostacyclin (PGI(2)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69912", "l": "adenosine(out) + 2 Na(+)(out) => adenosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139905", "l": "Translocation of activated BAD protein to mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57544", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}, {"i": "EC:1.14.14.160", "l": "\"zealexin A1 synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54732", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72340", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) => catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396113", "l": "Dystroglycan binds AGRN and HSPG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66154", "l": "CoA + H(+) + N-acetylnoradrenaline => acetyl-CoA + noradrenaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602466", "l": "Activation of MT-MMPs by FURIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33128", "l": "H2O + salicin-6-phosphate => beta-D-glucose 6-phosphate + salicyl alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858489", "l": "ppDVL binds DAAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29334", "l": "fumarate(in) + 2 H(+)(in) <=> fumarate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66135", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31118", "l": "ATP + biotin + H(+) <=> biotinyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70779", "l": "D-glucose + NADP(+) = 6-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.432", "l": "\"6-dehydroglucose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56972", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) = (R)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45260", "l": "tetracosanoate(out) = tetracosanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12071", "l": "apo-[ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936412", "l": "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72557", "l": "estrone 3-sulfate(in) + propanoate(out) => estrone 3-sulfate(out) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0010844", "l": "recombination hotspot binding", "d": ["Binding to a genomic region which promotes recombination."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66764", "l": "ATP + folate(in) + H2O = ADP + folate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45283", "l": "12-(phosphooxy)octadecanoate + H2O <=> 12-hydroxyoctadecanoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67755", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77412", "l": "acrolein + hydrogen cyanide => (2S)-2-hydroxybut-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679045", "l": "C-ter TLR9 dimer binds HCQ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619666", "l": "L-PRX:DRP2 binds dystroglycan and laminin-211 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222583", "l": "MscR reduces nitrosomycothiol to ammonia (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446694", "l": "IRAK4 phosphorylates IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17097", "l": "3-phenylpyruvate = enol-phenylpyruvate", "d": [], "t": []}, {"i": "EC:5.3.2.1", "l": "\"phenylpyruvate tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592278", "l": "Autocatalytic activation of proMMP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73590", "l": "CTP(out) + UMP(in) <=> CTP(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57151", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39650", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73076", "l": "luteolin + S-adenosyl-L-methionine => H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238691", "l": "N-linked glycosylation of WNTs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56510", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45342", "l": "(9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+) => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28732", "l": "H(+)(out) + L-leucine(in) => H(+)(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183052", "l": "CBL binds to GRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008145", "l": "phenylalkylamine binding", "d": ["Binding to phenylalkylamine or one of its derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042292", "l": "URM1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71161", "l": "H(+)(out) + L-serine(in) + Na(+)(in) => H(+)(in) + L-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45562", "l": "D-allo-isoleucine => L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19948", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.-.-", "l": "\"Catalysing the translocation amino acids and peptides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077424", "l": "Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030762", "l": "tetrahydrocolumbamine 2-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H+ + tetrahydropalmatine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990412", "l": "hercynylselenocysteine lyase activity (selenoneine-forming)", "d": ["Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium."], "t": []}, {"i": "RHEA:42696", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43045", "l": "hexadecasphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139895", "l": "tBID activates BAK protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39165", "l": "(3R)-hydroxyhexadecanoyl-CoA + NADP(+) => 3-oxohexadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754964", "l": "ADA deamidates RBV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16304", "l": "H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801101", "l": "RABGGTA binds RABGGTB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4791278", "l": "APC truncation mutants have impaired AXIN binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22376", "l": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.12", "l": "\"tRNA pseudouridine(38-40) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21417", "l": "NADP(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12655", "l": "CO2 + NADH + pyruvate => (S)-malate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669240", "l": "FLNA binds PAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74723", "l": "Endosome acidification (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57987", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31049", "l": "CO2 + NADH + propanoyl-CoA => (S)-2-methyl-3-oxopropanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45031", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74276", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A => a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102780", "l": "sitosterol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + sitosterol + O2 + NADPH = (22alpha)-hydroxy-sitosterol + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33969", "l": "3-maleylpyruvate + H(+) => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693081", "l": "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033989", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10522", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75585", "l": "erinacine Q + H(+) + UDP => 11-O-acetylcyathatriol + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944215", "l": "Association of procollagen type XX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799431", "l": "TP53 binds HIPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73643", "l": "CTP(out) + IDP(in) = CTP(in) + IDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214324", "l": "Collagen type VII dimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034795", "l": "cyclohexane monooxygenase activity", "d": ["Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18111", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54382", "l": "5-hydroxy-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11515", "l": "salicyl alcohol + UDP-alpha-D-glucose <=> H(+) + salicin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60953", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine => (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080032", "l": "methyl jasmonate esterase activity", "d": ["Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10942", "l": "(4R)-limonene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733973", "l": "Bile salts bind FABP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57009", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 => 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46469", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O => ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610752", "l": "GLI3R translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23497", "l": "5-hydroxypentanoate + acetyl-CoA => 5-hydroxy-pentanoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31767", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}, {"i": "EC:2.6.1.92", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19597", "l": "H2O + L-arginine = L-citrulline + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.6", "l": "\"arginine deiminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109860", "l": "MAP2K1 phosphorylates MAPK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42465", "l": "biphenyl-2,2',3-triol + O2 => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48152", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O = ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31515", "l": "4'-apo-beta-carotenal + H2O + NAD(+) = 2 H(+) + NADH + neurosporaxanthin", "d": [], "t": []}, {"i": "EC:1.2.1.82", "l": "\"beta-apo-4'-carotenal dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59873", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11230", "l": "(2S)-flavanone + H(+) + NADPH => (2S)-flavan-4-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60392", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O = Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10033", "l": "[protein]-C-terminal-L-glutamine + H2O => [protein]-C-terminal-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14666", "l": "guanine + H(+) + H2O => NH4(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58350", "l": "2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034797", "l": "fosfomycin 2-glutathione ligase activity", "d": ["Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51070", "l": "(3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25253", "l": "ATP + N-acetyl-D-mannosamine = ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74716", "l": "Insulin binds the insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51736", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449058", "l": "Interleukin-1 family are secreted (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41267", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)-tetracosenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381091", "l": "IRE1 dimer autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28747", "l": "NH4(+)(in) = NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54412", "l": "a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141100", "l": "tRNA (guanine(18)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 18 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 18 in tRNA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49427", "l": "ATP + validone <=> ADP + H(+) + validone 7-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72913", "l": "atranorin + S-adenosyl-L-homocysteine => proatranorin III + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46024", "l": "H2O2 + tetradecanoate = (3R)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55307", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76725", "l": "5-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40392", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA => 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31564", "l": "H2O + leukotriene C4 => L-glutamate + leukotriene D4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33409", "l": "diphosphate + glycyl-5'-AMP => ATP + glycine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710959", "l": "p-STAT1 dimer binds KPNA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30208", "l": "H2O + methylamine + 2 oxidized [amicyanin] => formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11165", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.46", "l": "\"glycerophosphodiester phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0098633", "l": "collagen fibril binding", "d": ["Binding to a collagen fibril."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29349", "l": "2 H(+)(out) + orotate(out) => 2 H(+)(in) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27340", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] <=> 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47067", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.50", "l": "\"tabersonine 3-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9646468", "l": "mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534096", "l": "METAP1/2 demethylates GNAT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41551", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980691", "l": "RHOA GEFs activate RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64688", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47474", "l": "(3E)-tetradecenoyl-CoA + NADP(+) => (2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095889", "l": "MMACHC dealkylates RCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68818", "l": "(E)-alpha-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76671", "l": "furfural + H2O + NADP(+) = 2-furoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65338", "l": "chrodrimanin A + H2O + NADP(+) => chrodrimanin T + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.3", "l": "\"lysine 5,6-aminomutase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28833", "l": "D-gluconate(out) + H(+)(out) => D-gluconate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0033695", "l": "oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule."], "t": []}, {"i": "EC:1.17.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40983", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.34", "l": "\"neutrophil collagenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32602", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> 3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848250", "l": "ACBD6 binds LCFA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047514", "l": "1,3-beta-D-glucan phosphorylase activity", "d": ["Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109858", "l": "MAP2K2 binds MAPK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981355", "l": "RASA1 binds RAS:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72741", "l": "chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25224", "l": "H(+) + L-cysteate <=> CO2 + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17962", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28666", "l": "H2O + melibiose <=> D-galactose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34204", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => aureusidin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0106075", "l": "peptide N-succinyltransferase activity", "d": ["Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65663", "l": "A + calciol + H2O <=> AH2 + calcidiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10629", "l": "phosphate + tRNA(n+1) => a ribonucleoside 5'-diphosphate + tRNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16772", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31320", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66878", "l": "12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19371", "l": "H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49054", "l": "asperlicin E + H2O + NAD(+) => asperlicin C + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71119", "l": "H(+) + hispidin + NADPH + O2 = 3-hydroxyhispidin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805059", "l": "CK2:FACT phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61101", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69475", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68583", "l": "ATP + H2O + L-kynurenine(out) <=> ADP + H(+) + L-kynurenine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25844", "l": "(1S,5R)-carveol + NAD(+) = (R)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24500", "l": "adenosine 5'-tetraphosphate + H2O = ATP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.14", "l": "\"adenosine-tetraphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67666", "l": "1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46064", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016793", "l": "triphosphoric monoester hydrolase activity", "d": ["Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050067", "l": "lysine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66246", "l": "diphosphate + IC-asc-C9-AMP => ATP + H(+) + IC-asc-C9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55489", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070337", "l": "3'-flap-structured DNA binding", "d": ["Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956676", "l": "YAP1 binds TP73 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65908", "l": "3-hydroxy-L-kynurenine + pyruvate = H2O + L-alanine + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17697", "l": "pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": [], "t": []}, {"i": "EC:2.5.1.2", "l": "\"thiamine pyridinylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46323", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A <=> 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202164", "l": "Translocation of PDK1 to Plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34281", "l": "di-trans,cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55560", "l": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047633", "l": "agmatine kinase activity", "d": ["Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196753", "l": "2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65973", "l": "a peptide antigen(in) + ATP + H2O => a peptide antigen(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59405", "l": "L-homoserine => D-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71442", "l": "L-dopa(out) + L-phenylalanine(in) <=> L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46862", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840795", "l": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645598", "l": "RRAGC,D hydrolyzes GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0004629", "l": "phospholipase C activity", "d": ["Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19248", "l": "N-phenylhydroxylamine <=> 2-aminophenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44107", "l": "decanal + H2O + NAD(+) <=> decanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209925", "l": "DIT and MIT combine to form triiodothyronine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995330", "l": "COX10 transforms heme to heme O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39751", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33701", "l": "(4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O => C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71609", "l": "(S)-malate(out) + phosphate(in) => (S)-malate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20987", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047162", "l": "17-O-deacetylvindoline O-acetyltransferase activity", "d": ["Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204779", "l": "Interaction of Tie2 with Ang1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.57655971136198", "identifiers": [{"i": "GO:0016769", "l": "transferase activity, transferring nitrogenous groups", "d": ["Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.6.-.-", "l": "\"Transferring nitrogenous groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180016", "l": "SUMO ligase regulator activity", "d": ["Binds to and modulates the activity of a SUMO ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404193", "l": "IGF1R phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29665", "l": "H(+)(out) + xanthine(out) => H(+)(in) + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382057", "l": "Release of novel PDGFs as latent factors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25161", "l": "2-oxoglutarate + L-ornithine => L-glutamate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835385", "l": "DUS2 binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354087", "l": "Recruitment of GRB2 to p-PTK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65317", "l": "2-oxoglutarate + chrodrimanin H + O2 => chrodrimanin E + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183051", "l": "CBL ubiquitinates Sprouty (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28128", "l": "alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55479", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981892", "l": "Active G alpha (z) binds RGS proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74444", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75989", "l": "a dicarboxylate(out) + indoxyl sulfate(in) => a dicarboxylate(in) + indoxyl sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102301", "l": "gamma-linolenate elongase activity", "d": ["Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70393", "l": "CoA + H(+) + N-eicosanoyl-3-oxosphinganine => 3-oxosphinganine + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450325", "l": "c-FOS activation by phospho ERK1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67958", "l": "(R)-lactate + chloride + H(+) => (S)-2-chloropropanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57146", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928591", "l": "EPH:EFN tetramers oligomerise (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864569", "l": "WWOX binds TFAP2C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448632", "l": "IL34 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52969", "l": "hyocholate + UDP-alpha-D-glucuronate => H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368069", "l": "NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49766", "l": "ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O => ethylenediaminetriacetate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24408", "l": "adenosine + H(+) + H2O = inosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672978", "l": "RAF phosphorylates MAP2K dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20224", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate <=> (6R)-10-formyltetrahydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008898", "l": "S-adenosylmethionine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31975", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46561", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156699", "l": "Inactivation of Wee1 kinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102733", "l": "typhasterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178208", "l": "SMAD7 binds to SMURF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30934", "l": "L-cysteine + O-acetyl-L-homoserine <=> acetate + H(+) + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39603", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA = (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71689", "l": "glycyl-L-aspartate(in) + 2 H(+)(in) => glycyl-L-aspartate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57434", "l": "1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34156", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61991", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37443", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41951", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62759", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034016", "l": "polyenoic fatty acid isomerase activity", "d": ["Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22958", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201515", "l": "Active ALK recruits PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72059", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) = glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.20", "l": "\"long-chain-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350578", "l": "NQO1 interaction with ODC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20674", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140741", "l": "WNT5A binds FZD and ROR receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10754", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.58", "l": "\"caspase-5\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.1", "l": "\"cathepsin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202709", "l": "JAM2 dimerises (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51265", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626928", "l": "CREBBP binds FOXO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22806", "l": "(6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH => (6S,9R)-vomifoliol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59315", "l": "D-galactose + O2 <=> D-galactono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74310", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052902", "l": "spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68308", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34879", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate = 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5195402", "l": "CDK1 phosphorylates LPIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727908", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PSMC6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102635", "l": "11-deoxycorticosterone reductase activity", "d": ["Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ = 4-pregnen-20,21-diol-3-one + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296043", "l": "Activation of HCN channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72866", "l": "3',3',3'-cAAG + H2O <=> G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77416", "l": "(2E)-but-2-enal + hydrogen cyanide => (2S,3E)-2-hydroxypent-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20755", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O <=> AH2 + 2 aquacob(III)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15836", "l": "(S)-4-hydroxymandelate + H(+) + O2 <=> 4-hydroxybenzaldehyde + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29571", "l": "H(+)(in) + L-idonate(in) = H(+)(out) + L-idonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015387", "l": "potassium:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)."], "t": []}, {"i": "RHEA:28490", "l": "H(+)(in) + K(+)(in) = H(+)(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28085", "l": "(2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64832", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA = 3-hydroxy-benzyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16677", "l": "fluoroacetaldehyde + H2O + NAD(+) = fluoroacetate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.69", "l": "\"fluoroacetaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170159", "l": "Translocation of Cdc25 to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031837", "l": "substance K receptor binding", "d": ["Binding to a substance K receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112434", "l": "Formation of DSIF complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73967", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937034", "l": "IRAK1 phosphorylates Pellino (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944254", "l": "Association of procollagen type XXVI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16533", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.94", "l": "\"protein N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22184", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.10.1.1", "l": "\"trans-acenaphthene-1,2-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445144", "l": "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429441", "l": "SYK activation by SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57412", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) = ATP + H(+) + L-tyrosine + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.101", "l": "\"L-tyrosine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57348", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O = 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202325", "l": "Recruitment of Gads to LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53677", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19609", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.182", "l": "\"16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67763", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66920", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate = (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32677", "l": "alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83788", "l": "Binding of TFIIIC to Type 2 promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55563", "l": "a hydroperoxyeicosatetraenoate <=> a hydroxy-epoxy-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24898", "l": "2 GTP = 3',3'-c-di-GMP + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.65", "l": "\"diguanylate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451347", "l": "Activation of JNK by DSCAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30869", "l": "(indol-3-yl)acetate + 2 H(+) + NADH => H2O + indole-3-acetaldehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39931", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39674", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18540", "l": "H2O + NAD(+) + salicylaldehyde <=> 2 H(+) + NADH + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23820", "l": "GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.47", "l": "\"GDP-mannose 4,6-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36660", "l": "carbamoyl phosphate + descarbamoylnovobiocin => novobiocin + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390044", "l": "YKI is phosphorylated by and then dissociates from phosphorylated WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16024", "l": "oxaloacetate <=> enol-oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36182", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395517", "l": "NADPH transfers electrons to FDXR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19481", "l": "acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.174", "l": "\"3-oxoadipyl-CoA thiolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034016", "l": "NTF3 binds NTRK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0046920", "l": "alpha-(1->3)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70594", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34943", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) = arbutin 6-phosphate(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37853", "l": "13-dihydrodaunorubicin + H2O + NADP(+) => 13-deoxydaunorubicin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202164", "l": "Translocation of PDK1 to Plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209944", "l": "25(OH)D binds GC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071861", "l": "tachykinin receptor binding", "d": ["Binding to a tachykinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30736", "l": "1D-myo-inositol 4-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000310", "l": "AURKA phosphorylates PLK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824219", "l": "Expression of NOTCH1 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198508", "l": "MDH1 oxidizes MAL to OA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45559", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65816", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444516", "l": "Formation of MSH2:MSH6 Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40707", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015083", "l": "aluminum ion transmembrane transporter activity", "d": ["Enables the transfer of aluminum (Al) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374686", "l": "L1 interaction with Integrins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19143", "l": "11-cis-retinol => all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13804", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) <=> 4 H(+) + 3 NADPH + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50352", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH = 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24957", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate => (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74678", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205286", "l": "GRB2:SOS interacts with p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3311014", "l": "SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10259", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202328", "l": "Translocation of PKC theta to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12376", "l": "ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.51", "l": "\"L-fuculokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46197", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647746", "l": "EML4 trimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22248", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.18", "l": "\"kynurenate-7,8-dihydrodiol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46306", "l": "16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37432", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989749", "l": "Expression of ACOX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0003872", "l": "6-phosphofructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654510", "l": "FGFRL1 binds SPRED1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36696", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid => desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200406", "l": "CPT1A,B transfers PALM to CAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685607", "l": "Sialic acid binds SIGLEC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322434", "l": "XIAP dissociates from ub-TLE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53370", "l": "H(+) + NADPH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0003934", "l": "GTP cyclohydrolase I activity", "d": ["Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12469", "l": "avenacoside A + H2O => 26-desgluco-avenacoside A + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32269", "l": "glycine + succinate semialdehyde => 4-aminobutanoate + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63268", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62713", "l": "betaenone C + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72485", "l": "(S)-malate(out) + citrate(in) => (S)-malate(in) + citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75113", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664332", "l": "CREB1 binds IL-10 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49968", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11512", "l": "salicyl alcohol + UDP-alpha-D-glucose = H(+) + salicin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.172", "l": "\"salicyl-alcohol beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043721", "l": "4-hydroxybutanoyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72858", "l": "ADP(out) + dADP(in) <=> ADP(in) + dADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097600", "l": "exoxylanase activity", "d": ["A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420206", "l": "Phosphorylation of SRC-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46688", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A = 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43767", "l": "ATP + chenodeoxycholate + CoA <=> AMP + chenodeoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58836", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029680", "l": "Caspase-7 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017056", "l": "structural constituent of nuclear pore", "d": ["The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193650", "l": "p75NTR binds to NADE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045295", "l": "gamma-catenin binding", "d": ["Binding to catenin complex gamma subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68156", "l": "(2E)-geranyl diphosphate + L-glutamate = diphosphate + N-geranyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74716", "l": "Insulin binds the insulin receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033449", "l": "GUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37472", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11019", "l": "allantoate + H2O <=> (S)-ureidoglycolate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65914", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine => 3-hydroxy-L-kynurenine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64432", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) = H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444527", "l": "FPR is a receptor for formyl peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855648", "l": "SALM3 binds LAR-RPTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26430", "l": "(+)-copalyl diphosphate + H2O = diphosphate + phyllocladan-16alpha-ol", "d": [], "t": []}, {"i": "EC:4.2.3.45", "l": "\"phyllocladan-16alpha-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222342", "l": "Hydroperoxyl enters the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730882", "l": "Phosphorylation of PKC-theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40848", "l": "eicosanoyl-CoA + FAD + H(+) => (2E)-eicosenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58148", "l": "ethyl acetate + H2O = acetate + ethanol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.113", "l": "\"ethyl acetate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53343", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64394", "l": "a dipeptide(in) + H(+)(in) => a dipeptide(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61724", "l": "a D-glucoside + NAD(+) = a 3-dehydro-D-glucoside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195304", "l": "Association of beta-catenin with the destruction complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72007", "l": "succinate(in) + urate(out) = succinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102049", "l": "indole-3-acetyl-methionine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) = H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047722", "l": "indolelactate dehydrogenase (NADH) activity", "d": ["Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD+ = 3-(indol-3-yl)pyruvate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203613", "l": "depalmitoylation of eNOS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67573", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate => adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844955", "l": "CLN3 transports GalCer to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55773", "l": "a jasmonate + an L-alpha-amino acid + ATP => a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679029", "l": "C-ter TLR7 dimer binds HCQ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55121", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69633", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50190", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69031", "l": "5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23827", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) <=> 2,3-dihydroxybenzoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53425", "l": "a fatty acyl-CoA + a sphingoid base => an N-acyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102025", "l": "ABC-type thiosulfate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67933", "l": "ATP + desmosterol(in) + H2O => ADP + desmosterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76972", "l": "1-(9Z-octadecenoyl)-2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O => (9Z)-octadecenoate + 2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37624", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035987", "l": "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39317", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51596", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369028", "l": "ABCAs mediate lipid efflux (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854466", "l": "VLDLR binds RELN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161506", "l": "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186780", "l": "PI3-kinase binds to the active receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428287", "l": "IGF2BP3 binds specific RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76965", "l": "2-hexyl-5-(7-hydroxyheptyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hexyl-5-heptylresorcinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254392", "l": "PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19169", "l": "L-serine = NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.3.1.17", "l": "\"L-serine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66979", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35896", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53466", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate => 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018807", "l": "RAC3 GDIs block activation of RAC3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35872", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39629", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72326", "l": "3 Na(+)(out) + thiosulfate(out) <=> 3 Na(+)(in) + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030343", "l": "vitamin D3 25-hydroxylase activity", "d": ["Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706287", "l": "Active FLT3 binds to ABL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46051", "l": "D-galactosamine 6-phosphate <=> alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696271", "l": "RND1 binds effectors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008445", "l": "D-aspartate oxidase activity", "d": ["Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59114", "l": "ADP + H(+) + O-phospho-L-serine => ATP + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34263", "l": "dimethylallyl diphosphate + fumigaclavine A = diphosphate + fumigaclavine C", "d": [], "t": []}, {"i": "EC:2.5.1.100", "l": "\"fumigaclavine A dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793852", "l": "DLL3 binds NOTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51159", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61926", "l": "(2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate => (2S,4R)-ketoconazole(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004159", "l": "dihydropyrimidine dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51120", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 = (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381091", "l": "IRE1 dimer autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70977", "l": "3-sulfino-L-alanine(in) + L-aspartate(out) => 3-sulfino-L-alanine(out) + L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29265", "l": "L-leucine(out) + Na(+)(out) => L-leucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41760", "l": "a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29340", "l": "(S)-malate(in) + 2 H(+)(in) => (S)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031719", "l": "type 2 cannabinoid receptor binding", "d": ["Binding to a type 2 cannabinoid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097216", "l": "guanosine tetraphosphate binding", "d": ["Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43697", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate => diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55340", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106219", "l": "zinc ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42626", "l": "(Z)-3-aminoacrylate + CO2 + NH4(+) => (Z)-3-ureidoacrylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.20", "l": "\"methylenetetrahydrofolate reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.2", "l": "\"acid phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68689", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) => 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193641", "l": "IKK-beta is recruited (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16504", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21896", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25717", "l": "H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950782", "l": "p-STAT1 binds p-STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25786", "l": "(S)-lactaldehyde + pyruvate => 2-dehydro-3-deoxy-L-rhamnonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209135", "l": "GISH further phosphorylates ARR in the receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473584", "l": "Collagen type III degradation by MMP15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202966", "l": "Caspase mediated cleavage of HIP-55 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809521", "l": "BPIF binds bacteria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47520", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isolithocholate + NADP(+)", "d": [], "t": []}, {"i": "EC:1.1.1.393", "l": "\"3beta-hydroxycholanate 3-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41104", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32109", "l": "H(+) + pterostilbene + S-adenosyl-L-homocysteine => 3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102600", "l": "cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity", "d": ["Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030791", "l": "arsenite methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72921", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II => 4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16881", "l": "hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate", "d": [], "t": []}, {"i": "EC:2.8.1.1", "l": "\"thiosulfate sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034920", "l": "pyrene dioxygenase activity", "d": ["Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41771", "l": "a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74626", "l": "AMP(in) + UMP(out) <=> AMP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690701", "l": "SHP1 binds p-CD22 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70205", "l": "5,6-dihydroxyindole-N-methyl => N-methyldopaminechrome", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28511", "l": "arbutin 6-phosphate + H2O => beta-D-glucose 6-phosphate + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41562", "l": "(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O => (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159771", "l": "Furin cleaves pro-protein C to protein C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.1", "l": "\"nitrate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23766", "l": "H(+) + O-phospho-L-serine + phosphate => diphosphate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392513", "l": "Rap1 signal termination by Rap1GAPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710959", "l": "p-STAT1 dimer binds KPNA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781941", "l": "WNTs are secreted in exosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617829", "l": "Assembly of IFT A complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48009", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 => 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15931", "l": "CO2 + N-(hydroxymethyl)urea + 2 NH4(+) => 2 H(+) + 2 H2O + methylenediurea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102147", "l": "3'-O-methyltricetin O methyl transferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48073", "l": "a ganglioside GM1 (d18:1(4E)) + H2O => a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004550", "l": "nucleoside diphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009034", "l": "tryptophanase activity", "d": ["Catalysis of the reaction: L-tryptophan + H2O = indole + NH4 + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24145", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650165", "l": "ASIC trimers bind H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70268", "l": "hydrogencarbonate(in) + Na(+)(in) => hydrogencarbonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0061594", "l": "6-deoxy-6-sulfofructose kinase activity", "d": ["Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218847", "l": "PAK2 binds NCK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62347", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate <=> diphosphate + notoamide S", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35879", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443780", "l": "Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28226", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.149", "l": "\"5-epiaristolochene 1,3-dihydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674140", "l": "PAQR3 binds inactive RAFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77646", "l": "adenosine 2',5'-bisphosphate + H2O <=> AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36097", "l": "methyl salicylate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15213", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = CoA + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2]", "d": [], "t": []}, {"i": "EC:2.3.1.61", "l": "\"dihydrolipoyllysine-residue succinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39219", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH = (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103042", "l": "4-hydroxy-L-threonine aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-threonine = glycolaldehyde + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33122", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-sativene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41724", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71933", "l": "fumarate(in) + 3 Na(+)(in) => fumarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928607", "l": "p-EPHs bind VAV2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57778", "l": "4-chloro-3-methylcatechol + NAD(+) + nitrite => 2-chloro-6-nitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.38", "l": "\"coagulation factor XIIa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031818", "l": "P2Y9 nucleotide receptor binding", "d": ["Binding to a P2Y9 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46810", "l": "[trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine => [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.20", "l": "\"beta-Ala-His dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20560", "l": "2 H(+) + H2O + urea <=> CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20495", "l": "an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634850", "l": "NPAS4 binds ARNT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62497", "l": "ATP + H(+) + L-arginine => diphosphate + L-arginyl-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40761", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665286", "l": "Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61901", "l": "AH2 + betaenone C => A + betaenone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70619", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52045", "l": "mogrol + UDP-alpha-D-glucose => H(+) + mogroside IE + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38218", "l": "D-glucose 6-phosphate + NAD(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19959", "l": "2 9-riburonosylhypoxanthine + 2 H(+) => 2 5'-dehydroinosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11612", "l": "H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74495", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694521", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990473", "l": "ciliary targeting signal binding", "d": ["Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917693", "l": "ESCRT Disassembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21648", "l": "H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.51", "l": "\"prephenate dehydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47791", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35823", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) = 7,8-dihydromethanopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16948", "l": "(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14882", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) => asparagusate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57693", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197770", "l": "STAB1 (FEEL-1) binds ligands (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376122", "l": "DSCAM/DSCAML1 homodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73301", "l": "(S)-malate(in) + H(+)(out) + phosphate(out) => (S)-malate(out) + H(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43497", "l": "L-gulonate + NAD(+) => H(+) + keto-D-fructuronate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102760", "l": "6-deoxocathasterone hydroxylase activity", "d": ["Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor = 6-deoxoteasterone + H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16108", "l": "a (3S)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047636", "l": "alanopine dehydrogenase activity", "d": ["Catalysis of the reaction: 2,2'-iminodipropanoate + H2O + NAD+ = L-alanine + H+ + NADH + pyruvate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430308", "l": "PARVB interacts with Alpha-actinin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5227009", "l": "ABCF1 binds EIF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63837", "l": "hexadecanoate + O2 => (2R)-2-hydroperoxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50972", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13764", "l": "L-methionine + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69074", "l": "Formation of Processive Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61256", "l": "H2O + L-cysteine + O2 = 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27576", "l": "(3R)-piperidine-3-carboxylate + NH4(+) => (3R)-piperidine-3-carboxamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480509", "l": "Expression of EPHA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43972", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16359", "l": "AH2 + fumarate => A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72882", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate <=> NH4(+) + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32399", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51835", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50858", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56916", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56717", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33707", "l": "ATP + L-threonine = ADP + H(+) + O-phospho-L-threonine", "d": [], "t": []}, {"i": "EC:2.7.1.177", "l": "\"L-threonine kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218814", "l": "PAK2 autophorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71062", "l": "L-arginine(in) + L-leucine(out) <=> L-arginine(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28253", "l": "acetyl-CoA + H(+) + malonyl-CoA <=> acetoacetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205286", "l": "GRB2:SOS interacts with p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950183", "l": "IL12B binds IL23A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70278", "l": "H2O + raffinose <=> D-galactose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014454", "l": "RHOG translocates to the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647978", "l": "pro-RAS proteins are farnesylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53874", "l": "CDP-D-ribose + diphosphate => CTP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47324", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate = 3-oxo-3-phenylpropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56611", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O <=> L-serine + tetrahydrosulfopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16125", "l": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49415", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose <=> alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017129", "l": "triglyceride binding", "d": ["Binding to a triester of glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54062", "l": "(2Z,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13355", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16501", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": [], "t": []}, {"i": "EC:3.1.4.44", "l": "\"glycerophosphoinositol glycerophosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47780", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621370", "l": "SYK autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50056", "l": "ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047833", "l": "D-sorbitol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9793472", "l": "RIPK3 binds p-S9-PRKN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73391", "l": "H(+)(in) + phosphate(in) + sulfate(out) = H(+)(out) + phosphate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004325", "l": "ferrochelatase activity", "d": ["Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043774", "l": "coenzyme F420-2 alpha-glutamyl ligase activity", "d": ["Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033957", "l": "lambda-carrageenase activity", "d": ["Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40088", "l": "22-hydroxydocosanoate + NAD(+) => 22-oxodocosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050122", "l": "N-acylhexosamine oxidase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + O2 = N-acetyl-D-glucosaminate + H2O2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448673", "l": "Formation of caspase-1 p10/p20 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39862", "l": "a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51071", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate <=> (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28273", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(8)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420977", "l": "Ca permeable AMPA receptor ligand binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350467", "l": "GUG binds to FT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25188", "l": "1,2-dichloroethane + H2O <=> 2-chloroethanol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42173", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 => (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75453", "l": "(13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615348", "l": "AGT(34-41) binds to AGTR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48888", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13324", "l": "(R)-3,3-dimethylmalate + NAD(+) <=> 3-methyl-2-oxobutanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40552", "l": "demethylphylloquinol + S-adenosyl-L-methionine => H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33586", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate <=> 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30842", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose <=> UDP-N-acetyl-beta-L-fucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810937", "l": "Lamellar bodies bind the early cornified envelope (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788611", "l": "HYKK phosphorylates 5HLYS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047790", "l": "creatinine deaminase activity", "d": ["Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73562", "l": "dGTP(out) + UTP(in) <=> dGTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74987", "l": "TTF-I binds to the Sal Box (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202969", "l": "Caspase mediated cleavage of beta-catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28325", "l": "UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64010", "l": "CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44905", "l": "alpha-D-glucose 6-phosphate + H2O => alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17933", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.150", "l": "\"isoflavone 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52002", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64933", "l": "dGTP + 2 H2O => dGMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48079", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51562", "l": "(S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine => (S)-bulbocapnine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11601", "l": "ATP + CMP => ADP + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443774", "l": "Trans-homodimerization of Neurofascin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58553", "l": "15alpha-stemmadenine intermediate II + H2O => (16R)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14524", "l": "(2E)-geraniol + NADP(+) <=> (2E)-geranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24982", "l": "3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate => 3-hydroxy-4-methylanthranilate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050341", "l": "thymine dioxygenase activity", "d": ["Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17017", "l": "acetyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = CoA + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.80", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612501", "l": "SGK phosphorylates CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047248", "l": "nuatigenin 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: nuatigenin + UDP-D-glucose = H+ + nuatigenin 3-beta-D-glucopyranoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52962", "l": "hyocholoyl-24-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26015", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate => 3-dehydroquinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45256", "l": "hexadecanoate(out) = hexadecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46377", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22733", "l": "4-hydroxyphenylacetate + H(+) => 4-methylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18737", "l": "ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate", "d": [], "t": []}, {"i": "EC:2.7.9.3", "l": "\"selenide, water dikinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72165", "l": "chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in) => chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23871", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA <=> acetyl-CoA + cyclohexanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651828", "l": "PARG dePARylates PARP1,PARP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70020", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol => 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70933", "l": "chloride(in) + dopamine(in) + 2 Na(+)(in) => chloride(out) + dopamine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795147", "l": "Apical excretion of sulfo-Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53833", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 => a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50388", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.234", "l": "\"12-dehydrotetracycline 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043337", "l": "cardiolipin synthase (CMP-forming)", "d": ["Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32806", "l": "ATP + H2O + urea(out) <=> ADP + H(+) + phosphate + urea(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607736", "l": "MALT1 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74822", "l": "glutathione(in) <=> glutathione(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111966", "l": "GRK2 binds CALM1:4Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928641", "l": "PAK binds RAC and bPIX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33869", "l": "glycine + N-carbamoyl-2-oxoglycine => (S)-2-ureidoglycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.130", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22029", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol => CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.239663535624402", "identifiers": [{"i": "GO:0004519", "l": "endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796053", "l": "PRKCI phosphorylates NFE2L2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56956", "l": "ITP + pyruvate = H(+) + IDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28505", "l": "NAD(+) + S-(hydroxymethyl)mycothiol <=> H(+) + NADH + S-formylmycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944214", "l": "Association of procollagen type I (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72781", "l": "FAD + 2 H2O + ochratoxin A => chloride + FADH2 + O2 + ochratoxin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72215", "l": "2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22470", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate => GTP + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23357", "l": "ATP + L-seryl-[rhodopsin] => ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34609", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22918", "l": "4-acetoxyphenol + H2O + NADP(+) => 4'-hydroxyacetophenone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374298", "l": "Opioid receptors bind opioid peptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55939", "l": "all-trans-4-hydroxyretinol + NAD(+) <=> all-trans-4-hydroxyretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62009", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51595", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene <=> benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59531", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172405", "l": "Collagen type XXIII ectodomain shedding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111930", "l": "Adenylate cyclase produces cAMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57596", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22215", "l": "(2R,3R)-tartrate <=> (2R,3S)-tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934742", "l": "RUNX1 binds PRMT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9623384", "l": "α1-agonists bind ADRA1A,B,D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661419", "l": "ALB binds extracellular heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420688", "l": "GABAB heterodimeric receptor binds GABA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11882", "l": "6-hydroxypseudooxynicotine + H2O2 => (S)-6-hydroxynicotine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781941", "l": "WNTs are secreted in exosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186780", "l": "Degradation of Ub-SMAD7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45016", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine = L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49749", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NADP(+) + proviolacein", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52594", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH => deoxycholoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60054", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39985", "l": "a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O => a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.55", "l": "\"pitrilysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34376", "l": "4-guanidinobutanamide + H2O => 4-guanidinobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58241", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => ADP-D-ribose + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211650", "l": "Autophosphorylation of PAK-2p34 in the activation loop (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082356", "l": "HSF1-mediated gene expression (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48041", "l": "a globoside Gb4Cer + H2O => a globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29898", "l": "ATP + H2O + L-glutamine(out) <=> ADP + H(+) + L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47863", "l": "a ganglioside GT1b (d18:1(4E)) + H2O <=> a ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71142", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH <=> 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62608", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 = S-sulfanylglutathione + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58071", "l": "(E)-isoeugenol + O2 <=> acetaldehyde + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41467", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16936", "l": "1-aminocyclopropane-1-carboxylate + H2O <=> 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810392", "l": "TMEM55B translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30523", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.34", "l": "\"coenzyme F420-1:gamma-L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694441", "l": "CSNK1D phosphorylates SEC23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74494", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> yaequinolone D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033785", "l": "heptose 7-phosphate kinase activity", "d": ["Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42796", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70778", "l": "6-sulfo-D-quinovose + FMNH2 + O2 <=> 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428609", "l": "Type I Na+-coupled phosphate co-transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72043", "l": "L-glutamate(in) + orotate(out) = L-glutamate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382057", "l": "Release of novel PDGFs as latent factors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18079", "l": "H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide => L-arginyl-[dinitrogen reductase] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41442", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate => (2-aminoethyl)phosphonate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928576", "l": "RHOA:GTP binds ROCK, activating it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68103", "l": "NAD(+) + xylitol <=> H(+) + L-xylulose + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56860", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.277", "l": "\"2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24265", "l": "D-xylulose 5-phosphate + formaldehyde => D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618559", "l": "EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176175", "l": "Stalling of DNA replication fork and RPA binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58011", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357445", "l": "PAK1-3 dimer disassociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59846", "l": "(R)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (+)-dehydrodiconiferyl alcohol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004756", "l": "selenide, water dikinase activity", "d": ["Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55409", "l": "[phosphate](n) + CTP => [phosphate](n+1) + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71222", "l": "2 Na(+)(out) + nitrate(out) <=> 2 Na(+)(in) + nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31379", "l": "H2O + pyrrole-2-carboxylate = 1H-pyrrole + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47682", "l": "D-tagatopyranose 1-phosphate + NH4(+) => D-galactosamine 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57177", "l": "L-arginyl-[protein] + methylglyoxal => N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33179", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.11", "l": "\"phosphoinositide phospholipase C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18806", "l": "[DsbA protein]-disulfide + [protein]-dithiol => [DsbA protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36249", "l": "(E)-anethole + H(+) + S-adenosyl-L-homocysteine => (E)-anol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52390", "l": "4-O-phospho-D-threonate + ADP + H(+) => ATP + D-threonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28097", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O <=> di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10737", "l": "a primary alcohol + NAD(+) => an aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19443", "l": "3-hydroxy-cis,cis-muconate + 2 H(+) => benzene-1,2,4-triol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22299", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30317", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => 1,7-dimethylxanthine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60293", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65920", "l": "L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10461", "l": "prostaglandin A1 => prostaglandin C1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.134", "l": "\"beta-amyrin 24-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46742", "l": "desmosterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14683", "l": "2-aminophenoxazin-3-one + AH2 + 2 H2O => 2 2-aminophenol + A + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240957", "l": "Formation of PRC2-EZH2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168638", "l": "Activated IKK phosphorylates I-kappaB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65450", "l": "CoA + ethyl butanoate => butanoyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982645", "l": "GRKs bind ADRB2:Catecholamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73896", "l": "ATP + L-glutamate + spermine => ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47080", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65599", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010951", "l": "ROBO1 binds NRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35178", "l": "novobiocin(in) <=> novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76726", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854462", "l": "VLDLR binds VLDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27899", "l": "3'-AMP + H2O => adenosine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372529", "l": "Release of acetylcholine at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446634", "l": "IRAK4 is activated by autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63981", "l": "4-thiouridine + ATP => 4-thiouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29816", "l": "ATP + H2O + L-proline(out) => ADP + H(+) + L-proline(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10756", "l": "ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43142", "l": "2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(26) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048101", "l": "calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity", "d": ["Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71155", "l": "(E)-caffeoylpyruvate + H2O = (E)-caffeate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37131", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416516", "l": "GRK2 sequesters activated Gq (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202325", "l": "Recruitment of Gads to LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070052", "l": "collagen V binding", "d": ["Binding to a type V collagen trimer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75674", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate <=> 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56353", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26218", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48818", "l": "17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716913", "l": "ESR1 binds ESR1 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67883", "l": "3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48053", "l": "n 3'-phosphoadenylyl sulfate + dermatan => n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0022855", "l": "protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199425", "l": "PHLPP dephosphorylates S473 in AKT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050540", "l": "2-aminomuconate deaminase activity", "d": ["Catalysis of the reaction: 2-aminomuconate + H2O + H+ = (Z)-5-oxohex-2-enedioate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69537", "l": "alpha-D-tagatopyranose 1-phosphate + ATP => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26458", "l": "ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22536", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.89", "l": "\"tetrahydrocolumbamine 2-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33231", "l": "H2O2 + heme b = heme d cis-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52068", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16067", "l": "2-hydroxyphytanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + phytanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.48", "l": "\"ruberlysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.806983861220772", "identifiers": [{"i": "GO:0016878", "l": "acid-thiol ligase activity", "d": ["Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669854", "l": "KIT binds type II TKIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22951", "l": "D-tagatofuranose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31151", "l": "H2O + L-selenocystathionine = 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53638", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10439", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62092", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007546", "l": "E2F6 binds RAD51 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680388", "l": "CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.48", "l": "\"plasminogen activator Pla\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805507", "l": "APAF1 binds AVEN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-350769", "l": "trans-Golgi Network Coat Activation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12236", "l": "H2O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.17.1.5", "l": "\"nicotinate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49358", "l": "2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42820", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 = H2O + 2 NADP(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016618", "l": "hydroxypyruvate reductase activity", "d": ["Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72187", "l": "H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50378", "l": "a ceramide(out) + ADP + H(+) + phosphate => a ceramide(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047443", "l": "4-hydroxy-4-methyl-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23368", "l": "H(+) + phenylglyoxylate = benzaldehyde + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.7", "l": "\"benzoylformate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13754", "l": "2 L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047756", "l": "chondroitin 4-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54555", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57334", "l": "3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite => H2O + 3 O2 + 3 propionate 3-nitronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004581", "l": "dolichyl-phosphate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28457", "l": "N(6)-(D-fructosyl)-L-lysine(in) <=> N(6)-(D-fructosyl)-L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0097157", "l": "pre-mRNA intronic binding", "d": ["Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60696", "l": "(R)-lavandulyl diphosphate + H2O = (R)-lavandulol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821486", "l": "HCFC1 binds SET1A complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43784", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.286", "l": "\"25S rRNA (adenine(2142)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74808", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0035014", "l": "phosphatidylinositol 3-kinase regulator activity", "d": ["Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38832", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205231", "l": "Dimerization of KIT upon SCF binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013895", "l": "Caspase-8 processing within TLR3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27784", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-octaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76536", "l": "FAD(in) => FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990446", "l": "U1 snRNP binding", "d": ["Binding to a U1 small nuclear ribonucleoprotein particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29533", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56686", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine => dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44090", "l": "AMP + diphosphate + heptanoyl-CoA => ATP + CoA + heptanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450466", "l": "AUF1:mRNA complex is destroyed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15430", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615682", "l": "Complexed PIWIL1 binds pre-piRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32426", "l": "(1R,4R)-dihydrocarvone + A <=> (R)-carvone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16075", "l": "CO2 + dialkyl ketone + L-alanine => 2,2-dialkylglycine + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790038", "l": "Expression of HSP90B1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16904", "l": "acetyl-CoA + L-2,4-diaminobutanoate <=> (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15307", "l": "glycine betaine + 2 H(+) + NADH => betaine aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14769", "l": "(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943728", "l": "SALL4 binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10294", "l": "CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate => acetyl-CoA + D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102721", "l": "ubiquinol:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215295", "l": "USP7 deubiquitinates MDM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30096", "l": "(S)-malate + a menaquinone => a menaquinol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754130", "l": "CDK4 inhibitors bind CDK4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636397", "l": "PtpA binds ATP6V1H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37123", "l": "sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12495", "l": "L-methionine <=> D-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29851", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine = 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693125", "l": "RHOF binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69059", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770141", "l": "Formation of the Spliceosomal C* complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2167942", "l": "Collagen type XIII ectodomain shedding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17559", "l": "CoA + N-malonylanthranilate => anthranilate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28395", "l": "L-alanyl-L-glutamate => L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140442", "l": "peroxide sensor activity", "d": ["Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047826", "l": "D-lysine 5,6-aminomutase activity", "d": ["Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53537", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.14", "l": "\"2-hydroxy-6-oxonona-2,4-dienedioate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420724", "l": "CASR binds Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42545", "l": "uridine(32) in tRNA => pseudouridine(32) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109858", "l": "MAP2K2 binds MAPK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752118", "l": "SPP1 (osteopontin) binds Integrin alpha4beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004135", "l": "amylo-alpha-1,6-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58087", "l": "1-(13Z-docosenoyl)-glycerol + H2O <=> (13Z)-docosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49352", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004360", "l": "glutamine-fructose-6-phosphate transaminase (isomerizing) activity", "d": ["Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693347", "l": "HTR1A binds 5HT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012835", "l": "GDIs block activation of RHOA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60622", "l": "choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate => N-hexanoyl-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31957", "l": "9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50185", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333051", "l": "RPA1 binds HSF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58840", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038149", "l": "C-C motif chemokine 2 receptor activity", "d": ["Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47095", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) <=> dipicolinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73702", "l": "ADP(in) + dATP(out) <=> ADP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418858", "l": "RhoGTPase GEF's recruited to DCC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835411", "l": "FA core complex:HSP70s binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65521", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64647", "l": "butan-1-ol + propanoyl-CoA <=> butyl propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42484", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.198", "l": "\"protein-N(pi)-phosphohistidine--D-sorbitol phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26053", "l": "glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40830", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11629", "l": "a 2-oxocarboxylate + H(+) => an aldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72437", "l": "(E)-caffeoyl-CoA + AMP + H(+) => (E)-caffeoyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53381", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) => H(+) + NADH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0052890", "l": "oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin."], "t": []}, {"i": "EC:1.3.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.63", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60071", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36383", "l": "carbamoyl adenylate + tobramycin = AMP + H(+) + nebramycin 5'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111879", "l": "PIP2 hydrolysis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33178", "l": "4-hydroxyphenylacetate(in) <=> 4-hydroxyphenylacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12636", "l": "benzoate + H(+) + NADH + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73903", "l": "ATP + ethanolamine + L-glutamate = ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46544", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.17", "l": "\"sphingolipid 4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111238", "l": "Formation of ADAR2  homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193695", "l": "IRAK interacts with TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730872", "l": "Activation of Calcineurin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23555", "l": "2-methylpropane-1,2-diol + NAD(+) <=> 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63191", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine <=> A + H2O + norbelladine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46235", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634850", "l": "NPAS4 binds ARNT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.44", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66457", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76213", "l": "GMP(out) => GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51640", "l": "(9Z,12Z)-octadecadienoate + O2 = (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656244", "l": "DRD2 binds DA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74498", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> yaequinolone C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37041", "l": "5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193636", "l": "p75NTR interacts with the NOGO receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21560", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": [], "t": []}, {"i": "EC:1.17.4.5", "l": "\"vitamin-K-epoxide reductase (warfarin-insensitive)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654511", "l": "FGFRL1 dimer binds FGFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47436", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O = (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617815", "l": "BBSome binds RAB3IP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16570", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 => (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53882", "l": "ADP + alpha,alpha-trehalose 6-phosphate + H(+) => ADP-alpha-D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018768", "l": "RHOU auto-activates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67503", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40146", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O <=> (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.44", "l": "\"atrolysin E\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57033", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O => CO2 + formate + methylamine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16354", "l": "2-oxoglutarate + taurine => L-glutamate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44263", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624272", "l": "MMPs cleave HB-EGF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34200", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => bracteatin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17637", "l": "squalene = hop-22(29)-ene", "d": [], "t": []}, {"i": "EC:5.4.99.17", "l": "\"squalene--hopene cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34597", "l": "3-dehydro-15-methylhexadecasphinganine + CO2 + CoA => H(+) + isopentadecanoyl-CoA + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797554", "l": "ABP1 binds SHANK proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38635", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69674", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O <=> (2S)-naringenin + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730902", "l": "Oligomerization of p-CARMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990651", "l": "inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004339", "l": "glucan 1,4-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170964", "l": "FRS2 binds to active TrkA receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75606", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> plasmodiophorol A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73311", "l": "L-thyroxine sulfate(out) = L-thyroxine sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46999", "l": "6-hydroxy-N-methylmyosmine + H2O <=> 6-hydroxypseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45250", "l": "butanoate(in) => butanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75293", "l": "glyoxylate(out) + oxalate(in) => glyoxylate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646468", "l": "mTORC1 binds RHEB:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29842", "l": "L-idonate + NADP(+) <=> 2-dehydro-L-idonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35920", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose => H(+) + kanamycin D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25073", "l": "3-hydroxybenzoate + ATP + CoA <=> 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55672", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}, {"i": "EC:2.4.1.355", "l": "\"poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57858", "l": "(E)-6-hydroxyferuloyl-CoA + CO2 + succinate => (E)-feruloyl-CoA + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204861", "l": "Interaction of Tie2 and Shc1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71797", "l": "(R)-3-hydroxybutanoate(in) + H(+)(in) => (R)-3-hydroxybutanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754964", "l": "ADA deamidates RBV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604360", "l": "Initial activation of proMMP2 by MMP14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13941", "l": "ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.28", "l": "\"triokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77453", "l": "(2S)-2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyacetonitrile => hydrogen cyanide + piperonal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66027", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17957", "l": "3-oxopropanoate = H2O + propynoate", "d": [], "t": []}, {"i": "EC:4.2.1.27", "l": "\"acetylenecarboxylate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27658", "l": "2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9769235", "l": "MAGED1 binds NPAS4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72200", "l": "Ca(2+)(in) + 2 H(+)(out) => Ca(2+)(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76056", "l": "norreticuline + S-adenosyl-L-methionine => H(+) + reticuline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69336", "l": "(E)-alk-1-en-1-SO-peroxol = (Z)-alkanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351604", "l": "Noradrenaline translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009032", "l": "thymidine phosphorylase activity", "d": ["Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.129", "l": "\"endo-alpha-sialidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55517", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31539", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.232", "l": "\"naringenin 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733207", "l": "p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0051880", "l": "G-quadruplex DNA binding", "d": ["Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018706", "l": "pyrogallol hydroxytransferase activity", "d": ["Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.217", "l": "\"exo-acting protein-alpha-N-acetylgalactosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34928", "l": "H(+) + NADPH + selenodiglutathione => glutathione + glutathioselenol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669013", "l": "EDA-3 binds EDA2R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784734", "l": "PCSK9 binds LDLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69074", "l": "Formation of Processive Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928624", "l": "EPHBs bind EFNBs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37941", "l": "(8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61095", "l": "H2O + N(2)-acetyl-L-citrulline <=> acetate + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112379", "l": "Recruitment of elongation factors to form elongation complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30916", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57986", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside Rg3 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211340", "l": "Anthrax lef cleaves target cell MAP2K1 (MEK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33796", "l": "H2O + sucrose => alpha-D-glucose + beta-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55556", "l": "a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69140", "l": "RPA binds to the Flap (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74563", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate = aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45644", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070909", "l": "glutamate:gamma-aminobutyric acid antiporter activity", "d": ["Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009309", "l": "RUNX2 binds STUB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856808", "l": "Recruitment of AP-2 complex and clathrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0043548", "l": "phosphatidylinositol 3-kinase binding", "d": ["Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62618", "l": "a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+) => a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74502", "l": "H(+) + NADPH + yaequinolone D <=> H2O + NADP(+) + penigequinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656891", "l": "OPN1SW binds 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71736", "l": "formyl-CoA + succinate => formate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451309", "l": "Edited Kainate Receptor binds glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66468", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = (17E)-cheilanthenediol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73747", "l": "(R)-noradrenaline(in) + 2 H(+)(out) = (R)-noradrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9834821", "l": "p-PRKRA dimer binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21191", "l": "ATP + deamido-NAD(+) + NH4(+) <=> AMP + diphosphate + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62684", "l": "norrubrofusarin + S-adenosyl-L-methionine = H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10686", "l": "L-tyrosyl-[protein] + phosphate => H2O + O-phospho-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619376", "l": "CAMK1 binds calmodulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034618", "l": "arginine binding", "d": ["Binding to 2-amino-5-(carbamimidamido)pentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31342", "l": "acetate + ATP + holo-[ACP] <=> acetyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72526", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159771", "l": "Furin cleaves pro-protein C to protein C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62168", "l": "H2O + N,N'-diacetylchitobiose = acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:3.5.1.136", "l": "\"N,N'-diacetylchitobiose non-reducing end deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6794346", "l": "NRXNs bind NLGNs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52017", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13753", "l": "2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": [], "t": []}, {"i": "EC:1.4.1.14", "l": "\"glutamate synthase (NADH)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61825", "l": "pregnenolone + UDP-alpha-D-glucose => H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59314", "l": "D-galactono-1,5-lactone + H2O2 => D-galactose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26420", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70696", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) => chloride(in) + glycine(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810724", "l": "PI3 binds the bacterial surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61186", "l": "H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP => quercitrin + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39873", "l": "a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 3-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467794", "l": "Resolution of sister chromatids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139895", "l": "tBID activates BAK protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39600", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67370", "l": "acetate + L-glutamine => H2O + N-acetyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71607", "l": "(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047622", "l": "adenosine nucleosidase activity", "d": ["Catalysis of the reaction: adenosine + H2O = D-ribose + adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69888", "l": "Na(+)(out) + uridine(out) => Na(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67471", "l": "H2O + malonyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33939", "l": "H(+) + L-arginine + NADH + O2 = H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63658", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420202", "l": "Secretin receptor binds secretin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55954", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52768", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O = 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30817", "l": "beta-nicotinamide D-riboside + phosphate => beta-nicotinamide D-ribonucleotide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990465", "l": "aldehyde oxygenase (deformylating) activity", "d": ["Catalysis of the reaction a long-chain aldehyde + O2 + 2 NADPH = an alkane + formate + H2O + 2 NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17200", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 <=> 2 4-hydroxyphenylacetate + 2 CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65617", "l": "A + cholest-4-en-3-one + H2O => 25-hydroxycholest-4-en-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004465", "l": "lipoprotein lipase activity", "d": ["Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72090", "l": "2 Na(+)(out) + taurodeoxycholate(out) <=> 2 Na(+)(in) + taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63172", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA = (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49020", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70572", "l": "D-glucose(out) + Na(+)(out) => D-glucose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46970", "l": "AH2 + isopentenyldehydrorhodopin => A + dihydroisopentenyldehydrorhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445700", "l": "Myosin Binds ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14441", "l": "acetyl-CoA + gentamicin C = CoA + H(+) + N(3)-acetylgentamycin C", "d": [], "t": []}, {"i": "EC:2.3.1.60", "l": "\"gentamicin 3-N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45334", "l": "7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+) => 7,8-dihydroneopterin + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102056", "l": "11-hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60221", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30216", "l": "a menaquinol + 2 nitric oxide => a menaquinone + H2O + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.2", "l": "\"glutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58714", "l": "H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide => NADH + O2 + rifampicin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65405", "l": "butan-1-ol + hexanoyl-CoA => butyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981926", "l": "RAC1 and CDC42 activate PAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68157", "l": "(2E)-geranyl diphosphate + L-glutamate => diphosphate + N-geranyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17690", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate => adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210271", "l": "Interaction of DAP12 and MDL-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29254", "l": "2 H(+)(out) + Na(+)(in) <=> 2 H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65497", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH => 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019148", "l": "D-cysteine desulfhydrase activity", "d": ["Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3221982", "l": "BANP binds TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48448", "l": "a ganglioside GA2 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209921", "l": "Monoiodinated tyrosine can be deiodinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75107", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.204", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75850", "l": "Addition of the third nucleotide on the nascent transcript (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201717", "l": "CSNK2-mediated phosphorylation of DVL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63769", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48165", "l": "epoxypheophorbide a + H2O => H(+) + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77565", "l": "1-(9Z-octadecenoyl)-3-hexadecanoylglycerol + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876472", "l": "NPC2 binds CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22818", "l": "alpha-D-xylulofuranose => alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362386", "l": "Glycosylation of Hh (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373745", "l": "SDK1 homophillic interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38285", "l": "itaconyl-CoA + succinate => itaconate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865774", "l": "TTLLs polyglutamylate tubulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46311", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050559", "l": "copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37807", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63449", "l": "(2-aminoethyl)phosphonate + CTP => CMP-(2-aminoethyl)phosphonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41602", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76366", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72615", "l": "H(+)(out) + L-alanyl-L-valine(out) = H(+)(in) + L-alanyl-L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052634", "l": "C-19 gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66275", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675417", "l": "PEBP1 binds activated RAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66116", "l": "2-oxobutanoate + L-glutamine = (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54073", "l": "(2E)-geranyl diphosphate => beta-thujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22542", "l": "9-riburonosyladenine + H(+) + H2O2 => 5'-dehydroadenosine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015119", "l": "hexose phosphate transmembrane transporter activity", "d": ["Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102396", "l": "9-cis-10'-apo-beta-carotenal cleavage oxygenase activity", "d": ["Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 = carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66858", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate => (2E)-geranyl diphosphate + 3 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39256", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32556", "l": "(2E)-geranyl diphosphate + H2O => (R)-alpha-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66305", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75334", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) <=> chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64070", "l": "1-phenyl-1,2-propanedione + H(+) + NADH => (R)-phenylacetylcarbinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17563", "l": "acetate + choline + H(+) => acetylcholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60201", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39248", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA => (2E,11Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004814", "l": "arginine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31475", "l": "soyasapogenol B + UDP-alpha-D-glucuronate = H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20363", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017151", "l": "DEAD/H-box RNA helicase binding", "d": ["Binding to a DEAD/H-box RNA helicase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44301", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA => 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004151", "l": "dihydroorotase activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71071", "l": "L-arginine(in) + L-cysteine(out) = L-arginine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64069", "l": "(R)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23202", "l": "formaldehyde + H2O2 + L-lysine => H2O + N(6)-methyl-L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43932", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052840", "l": "inositol diphosphate tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53026", "l": "5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+) => a plastoquinone + H2O + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60460", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254291", "l": "ERBB4s80 binds STAT5A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617462", "l": "HOXD1 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610735", "l": "NUMB binds ITCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24289", "l": "5-formimidoyltetrahydrofolate + glycine => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252133", "l": "ATP6AP1 binds V-ATPase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73298", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507870", "l": "Aquaporins passively transport water out of cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40589", "l": "CoA + H(+) + octanedioate => H2O + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350651", "l": "Caspase-mediated cleavage of MASK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13084", "l": "biotin amide + H2O <=> biotin + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211968", "l": "CYP2W1 oxidises INDOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832908", "l": "ZNF521 binds the SOX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36184", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733766", "l": "MESP1 binds the GATA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30142", "l": "H2O + octadecanoyl-CoA <=> CoA + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75892", "l": "holothin + pseudomonoyl-CoA C => CoA + pseudomonic acid C--holothin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168888", "l": "Alpha1-Microglobulin binds heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45866", "l": "4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418925", "l": "ADORA2A,B bind Ade-Rib (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54457", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46774", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12606", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate => 1-deoxy-D-xylulose 5-phosphate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76456", "l": "O-atom dealkylation of dextromethorphan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76077", "l": "a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in) => a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.16", "l": "\"geosmin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72981", "l": "asterriquinone C1 + diphosphate => didemethylasterriquinone D + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42700", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.85", "l": "\"pimeloyl-[acyl-carrier protein] methyl ester esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043890", "l": "N-acetylgalactosamine-6-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39389", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15224", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799350", "l": "Exocytosis of specific granule membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52955", "l": "lithocholate + UDP-alpha-D-glucuronate <=> lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52130", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55008", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 = (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047628", "l": "ADP-thymidine kinase activity", "d": ["Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54538", "l": "a very long-chain fatty acyl-CoA + AMP + diphosphate => a very long-chain fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68664", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662613", "l": "MT3 exchanges zinc for copper (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68999", "l": "2-oxoglutarate + gibberellin A9 + O2 <=> CO2 + gibberellin A4 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11255", "l": "H(+) + hydroxylamine + L-asparagine <=> beta-L-aspartylhydroxamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46603", "l": "[HPr protein]-L-serine + ATP <=> [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65240", "l": "(11Z)-octadecenoyl-CoA + H2O = (11Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20593", "l": "H2O + N-acetyl-D-glucosamine = acetate + D-glucosamine", "d": [], "t": []}, {"i": "EC:3.5.1.33", "l": "\"N-acetylglucosamine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32985", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48915", "l": "a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51878", "l": "desmethylxanthohumol + diphosphate => 2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19547", "l": "glycerol + H(+) + phosphocholine => H2O + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944047", "l": "JUN binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33851", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) = GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857555", "l": "EGFR phosphorylates GPNMB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047285", "l": "flavonol-3-O-glycoside xylosyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44792", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine = H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451439", "l": "Activated TLR7 or 21 recruits MyD88 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61156", "l": "3'-dephospho-CoA + GTP = CoA + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.237", "l": "\"GTP-dependent dephospho-CoA kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380176", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13149", "l": "A + H(+) + NADPH = AH2 + NADP(+)", "d": [], "t": []}, {"i": "EC:1.6.99.1", "l": "\"NADPH dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66188", "l": "3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52076", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72912", "l": "proatranorin III + S-adenosyl-L-methionine => atranorin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047894", "l": "flavonol 3-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954082", "l": "E2F6 binds the PRC1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58896", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.2.1.56", "l": "\"4-hydroxybutyrate--CoA ligase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30503", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde = acetate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20359", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-phenylpropanoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168848", "l": "tBID binds to inactive BAK protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19177", "l": "L-lysine = (3S)-3,6-diaminohexanoate", "d": [], "t": []}, {"i": "EC:5.4.3.2", "l": "\"lysine 2,3-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72206", "l": "2 chloride(out) + hydrogencarbonate(in) <=> 2 chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66918", "l": "9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687625", "l": "ATP binds MLKL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63720", "l": "losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030305", "l": "heparanase activity", "d": ["Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains."], "t": []}, {"i": "REACT:R-HSA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75575", "l": "11-O-acetylcyathatriol + A = 11-O-acetylcyathin A3 + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71851", "l": "glycocholate(out) = glycocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810843", "l": "Envoplakin binds periplakin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46330", "l": "3-phenylpyruvate + NH4(+) => L-threo-3-phenylserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917696", "l": "Cargo Sequestration (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28564", "l": "pyridoxamine 5'-phosphate + pyruvate => D-alanine + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757256", "l": "MCM3 binds MCM5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62843", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63149", "l": "H2O + N-(9Z-octadecenoyl)-taurine => (9Z)-octadecenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65866", "l": "5alpha-androstan-1,3,17-trione + AH2 => 5alpha-androst-1-ene-3,17-dione + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408542", "l": "GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38589", "l": "devancoaminyl-vancomycin + UDP => UDP-alpha-D-glucose + vancomycin aglycone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11150", "l": "4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51945", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine => 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30851", "l": "beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72386", "l": "Na(+)(out) + urate(in) <=> Na(+)(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61311", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46299", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11040", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.19", "l": "\"imidazoleglycerol-phosphate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68851", "l": "(2Z,6E)-farnesyl diphosphate <=> diphosphate + gamma-cadinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61090", "l": "(2R,3R)-dihydroquercetin + CO2 + succinate => (S)-eriodictyol + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68092", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA = a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050040", "l": "lactate 2-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849463", "l": "PTK6 phosphorylates SFPQ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11693", "l": "NAD(+) + NADPH => NADH + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797553", "l": "Protein 4.1 binds CASK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732629", "l": "PPARG binds PPARG agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617595", "l": "SGTA binds mislocalized membrane protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800798", "l": "The PIDDosome binds CASP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31745", "l": "a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyflavanone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62665", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine => deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428749", "l": "Activated TP receptor binds G-proten Gq (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052730", "l": "sarcosine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50555", "l": "prostaglandin C1 <=> prostaglandin B1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421197", "l": "adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983266", "l": "Kinesins bind microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001785", "l": "prostaglandin J receptor activity", "d": ["Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48230", "l": "a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.57655971136198", "identifiers": [{"i": "GO:0140375", "l": "immune receptor activity", "d": ["Receiving a signal and transmitting it in a cell to initiate an immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72486", "l": "(S)-malate(in) + citrate(out) <=> (S)-malate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033910", "l": "glucan 1,4-alpha-maltotetraohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72572", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) => dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11322", "l": "UDP-alpha-D-xylose => UDP-beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72508", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) => 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194678", "l": "CYP51A1 demethylates LNSOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696997", "l": "USP24 deubiquitinates DDB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13849", "l": "D-arabinose = D-ribulose", "d": [], "t": []}, {"i": "EC:5.3.1.3", "l": "\"D-arabinose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10410", "l": "3-oxopristanoyl-CoA + CoA => 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35723", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380311", "l": "Recruitment of Plk1 to centrosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199043", "l": "LILRs interact with MHC Class I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38784", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26296", "l": "(1'S,5'S)-averufin + NADPH + O2 <=> 1'-hydroxyversicolorone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12587", "l": "16alpha-hydroxyprogesterone <=> 16,17-didehydroprogesterone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140663", "l": "ATP-dependent FeS chaperone activity", "d": ["Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29160", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444171", "l": "Receptor FFAR2 binds carboxylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102729", "l": "6-oxocampestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19337", "l": "2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH", "d": [], "t": []}, {"i": "EC:1.7.1.5", "l": "\"hyponitrite reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69279", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> but-3-enenitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141409", "l": "Mad1 binds kinetochore (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0016435", "l": "rRNA (guanine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450741", "l": "VANG, IN, FY, and FRTZ colocalise at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51689", "l": "galactitol + NAD(+) => H(+) + keto-L-tagatose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65410", "l": "NAD(+)(out) => NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77068", "l": "Activation of GT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879245", "l": "mycothiol binds formaldehyde and is dehydrogenated (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38865", "l": "alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate => phosphate + sucrose 6(F)-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15614", "l": "NAD(+) + precorrin-2 => 2 H(+) + NADH + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0031420", "l": "alkali metal ion binding", "d": ["Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102661", "l": "homogentisate solanyltransferase activity", "d": ["Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ = 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750660", "l": "Glycine conjugates translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.9", "l": "\"enteropeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51409", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14483", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76426", "l": "N-atom dealkylation of caffeine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1169192", "l": "PTP1B dephosphorylates GHR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375160", "l": "NCAM1 binds to ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15951", "l": "2-oxooctadecanoate + H(+) + NADH => (R)-2-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75714", "l": "a rhodoquinone + succinate <=> a rhodoquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168883", "l": "Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.9", "l": "\"photosystem II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54166", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38409", "l": "(9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38687", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O = (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814555", "l": "Integrator complex processes the 3' end of snRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40249", "l": "10-carboxy-13-deoxycarminomycin + H(+) + methanol => H2O + rhodomycin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048257", "l": "3'-flap endonuclease activity", "d": ["Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65651", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine <=> a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22889", "l": "(R)-methylmalonyl-CoA => succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350403", "l": "DGO binds to PK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45645", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27755", "l": "H2O + methylglyoxal => (R)-lactate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59834", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => ATP + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72019", "l": "2-oxoglutarate + H(+) + O2 + trihazone A = 2 CO2 + H2O + succinate + trihazone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21550", "l": "acetate + L-lysyl-[alpha-tubulin] => H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10618", "l": "(2R,3S,4S)-leucocyanidin + H(+) + NADPH => (2R,3S)-catechin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0017080", "l": "sodium channel regulator activity", "d": ["Binds to and modulates the activity of a sodium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73032", "l": "Cd(2+)(out) + H(+)(out) => Cd(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043727", "l": "5-amino-4-imidazole carboxylate lyase activity", "d": ["Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164508", "l": "N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25121", "l": "(S)-2-amino-6-oxohexanoate = H(+) + H2O + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45630", "l": "holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein] => holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18031", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + phosphate => 2 ATP + hydrogencarbonate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032561", "l": "guanyl ribonucleotide binding", "d": ["Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10872", "l": "H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.1.15", "l": "\"aspartoacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53056", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009485", "l": "IL34:CSF1 binds CSF1R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033288", "l": "ATPase-coupled hydroxyectoine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874079", "l": "PTK2 binds activated MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102978", "l": "furaneol oxidoreductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP = 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15799", "l": "biliverdin IXalpha + H(+) + NADH => bilirubin IXalpha + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33248", "l": "O2 + putrescine => 1-pyrroline + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18241", "l": "D-lysine = (2R,5S)-2,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668605", "l": "RAC2:GTP binds NOX2 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38283", "l": "itaconate + succinyl-CoA = itaconyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052756", "l": "chitobiose phosphorylase activity", "d": ["Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38275", "l": "(3R)-citramalyl-CoA = acetyl-CoA + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.46", "l": "\"(R)-citramalyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45604", "l": "D-glucaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102154", "l": "8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose = 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004755", "l": "saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NADP+ = L-allysine + L-glutamate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031815", "l": "P2Y5 nucleotide receptor binding", "d": ["Binding to a P2Y5 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179421", "l": "Degradation of multiubiquitinated Nek2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635843", "l": "GLI translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23463", "l": "benzyl cetraxate + H2O <=> benzyl alcohol + cetraxate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70001", "l": "L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51041", "l": "indole-3-pyruvate imine dimer => chromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201622", "l": "Caspase-mediated cleavage of gelsolin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008948", "l": "oxaloacetate decarboxylase activity", "d": ["Catalysis of the reaction: oxaloacetate = pyruvate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376419", "l": "Formation of NR-MED1 Coactivator Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40428", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983158", "l": "Trimming of peptides in ER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31228", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine => di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28711", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) = H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805109", "l": "CDK2 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12522", "l": "(E)-caffeate + NH4(+) => L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44123", "l": "hexadecanoyl-CoA + octadecan-1-ol <=> CoA + octadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21383", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694421", "l": "PP6 dephosphorylates SEC24 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56582", "l": "6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine => 6-thioguanine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14601", "l": "L-lysine + O2 = 5-aminopentanamide + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.13.12.2", "l": "\"lysine 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602892", "l": "Defective GCLC does not ligate L-Glu to L-Cys (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52606", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791095", "l": "Expression of HERPUD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46949", "l": "GTP + S-adenosyl-L-methionine => N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33667", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009072", "l": "STAT3 phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66345", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047351", "l": "GTP guanylyltransferase activity", "d": ["Catalysis of the reaction: 2 GTP + H+ = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40857", "l": "FADH2 + trans-2-undecenoyl-CoA => FAD + H(+) + undecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106320", "l": "(R)-limonene 1,2-monooxygenase NADPH activity", "d": ["Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847880", "l": "CYTH proteins bind ARF1:GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68906", "l": "3-phenylpropanal + AMP + diphosphate + NADP(+) => 3-phenylpropanoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11189", "l": "3-cyano-L-alanine + 2 H2O => L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102767", "l": "flavanone 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44423", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66210", "l": "(2E,8R)-8-hydroxynonenoyl-CoA + H2O2 => (8R)-8-hydroxynonanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35653", "l": "an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+) => (4R)-hydroxysphinganine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13684", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33731", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450533", "l": "PKCdelta phosphorylates HuR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48735", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O <=> [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604328", "l": "AKT1 phosphorylates NOTCH4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202127", "l": "eNOS synthesizes NO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849055", "l": "PTK6 binds ARHGAP35 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508513", "l": "PTK2B binds JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218806", "l": "FYN autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35054", "l": "N,N'-diacetylchitobiose(out) <=> N,N'-diacetylchitobiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610722", "l": "CK1 phosphorylates p-GLI3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35370", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH <=> isoheptadecanoyl-coA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757574", "l": "ALB binds PREDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18280", "l": "a thiol + S-adenosyl-L-methionine <=> a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604712", "l": "Initial activation of proMMP7 by trypsin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47450", "l": "(2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735335", "l": "Expression of HAND2 in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173542", "l": "SMURF2 ubiquitinates SMAD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112514", "l": "JAK activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35443", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose = an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.51", "l": "\"anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354273", "l": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635845", "l": "GLI proteins bind CDC73 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74785", "l": "tyramine(out) => tyramine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694549", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63518", "l": "biphenyl-2,2',3,3'-tetraol + H2O + NAD(+) => biphenyl-2,2',3-triol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43029", "l": "L-cysteate => 2-aminoprop-2-enoate + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19558", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione => 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48480", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30832", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21619", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69345", "l": "(E)-but-1-en-1-SO-peroxol => (Z)-butanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640195", "l": "RRAGA,B hydrolyzes GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20038", "l": "D-sorbitol 6-phosphate + NADP(+) => aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73844", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose => a sterol 27-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12900", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69091", "l": "butanal + H2O + NAD(+) <=> butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733292", "l": "AMY1-3 bind pramlintide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30747", "l": "FAD + H(+) + hexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018633", "l": "dimethyl sulfide monooxygenase activity", "d": ["Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211959", "l": "CYP3A43 6b-hydroxylates TEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933532", "l": "Processing of caspases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39788", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70686", "l": "(R)-normetanephrine + S-adenosyl-L-methionine <=> (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73811", "l": "L-proline(in) = L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050081", "l": "maltose-6'-phosphate glucosidase activity", "d": ["Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25974", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(8)-acetylspermidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14350", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20431", "l": "acacetin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026377", "l": "NTF4-bound NTRK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689000", "l": "AADAC deacetylates PHEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33294", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877922", "l": "BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.45", "l": "\"UDP-sugar diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810076", "l": "DDO oxidizes D-Asp to OA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693198", "l": "RHOD binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10468", "l": "D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": [], "t": []}, {"i": "EC:4.1.2.9", "l": "\"phosphoketolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199910", "l": "MSK1 activates ATF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983424", "l": "Budding of COPII coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102251", "l": "all-trans-beta-apo-10'-carotenal cleavage oxygenase activity", "d": ["Catalysis of the reaction: 10'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-708349", "l": "Activated NOD2 oligomerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795460", "l": "SGK1 phosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45621", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57518", "l": "15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dolabradiene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015539", "l": "hexuronate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692376", "l": "BCL2 binds BCL2 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74720", "l": "myricetin + S-adenosyl-L-methionine => 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017441", "l": "PPARG gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676599", "l": "sBAFF trimer binds BAFFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74185", "l": "H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether => S-adenosyl-L-methionine + taxifolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036382", "l": "flavin reductase (NADH) activity", "d": ["Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39663", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.1.98.4", "l": "\"F420H2:quinone oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874080", "l": "SRC phosphorylates PTK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22961", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22785", "l": "(2R)-O-phospho-3-sulfolactate => H(+) + phosphoenolpyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52895", "l": "H2O + NADP(+) + nitrosobenzene <=> H(+) + NADPH + nitrobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632677", "l": "PTCH is internalized (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63602", "l": "L-isoleucine + neocasomorphin-(1-5) => H2O + neocasomorphin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917841", "l": "Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419861", "l": "Melanospin is stimulated by light (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46066", "l": "(6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211206", "l": "Translocation of DFF to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222491", "l": "Lactoferrin scavenges iron ions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23796", "l": "17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59886", "l": "4-chloro-L-lysine + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75538", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 <=> (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019780", "l": "FAT10 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627369", "l": "SEPT4 binds XIAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73596", "l": "dCMP + H2O => dUMP + NH4+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23963", "l": "H(+) + 2 H2O2 + hexadecanoate <=> CO2 + 3 H2O + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008760", "l": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15823", "l": "2 AH2 + CO2 + hydrogen cyanide => 2 A + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36991", "l": "phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24631", "l": "2 H2O + 3 NAD(+) + NH4(+) <=> 5 H(+) + 3 NADH + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140947", "l": "histone H3K9me2 methyltransferase activity", "d": ["Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77717", "l": "a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62503", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP <=> AMP + H(+) + L-arginyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623643", "l": "RDH13 reduces atRAL to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27518", "l": "H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362549", "l": "Hh-Np traffics to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015111", "l": "Factor Xa inhibitors binds Xa (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69189", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35403", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) = (3R)-vestitone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37477", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9749197", "l": "ORC1 binds to H4K20me2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35832", "l": "2-oxoglutarate + kanamycin B + O2 => 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012597", "l": "GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40243", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65658", "l": "25-hydroxycholest-1,4-dien-3-one + AH2 => A + cholest-1,4-dien-3-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380782", "l": "STAT binds to the active receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443439", "l": "c-Src binds Raf1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25739", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448958", "l": "Nuclear translocation of p38 MAPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097023", "l": "fructose 6-phosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate."], "t": []}, {"i": "RHEA:28002", "l": "beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209823", "l": "Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47309", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56558", "l": "delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62816", "l": "4 monapinone E + O2 = 2 dinapinone E + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.20", "l": "\"trans-1,2-dihydrobenzene-1,2-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76473", "l": "A + cob(I)alamin + 2 H(+) => AH2 + cob(III)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30823", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}, {"i": "EC:4.2.1.135", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24707", "l": "(6R)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose => (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15812", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-linalool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214410", "l": "Monomeric PGN binds to PGRP-LE in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130627", "l": "MHC class II antigen internalization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174367", "l": "GCL ligates L-Glu to L-Cys (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50439", "l": "prostaglandin H1 <=> prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022141", "l": "Prolysyl oxidase activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11932", "l": "2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161619", "l": "PGI2 is hydrolysed to 6k-PGF1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75684", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 => (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31275", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) = (S)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35080", "l": "doxorubicin(in) => doxorubicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390912", "l": "HRH1 binds hist (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050511", "l": "undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38444", "l": "a fatty acyl-CoA + a long chain fatty alcohol => a wax ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72853", "l": "ADP(in) + AMP(out) => ADP(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62553", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050366", "l": "tyramine N-feruloyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70898", "l": "N-terminal L-cysteinyl-[protein] + O2 <=> H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14267", "l": "5-aminolevulinate => (S)-4-amino-5-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75998", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) <=> 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694633", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.56", "l": "\"caspase-3\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66450", "l": "(E)-2-pentenal + H(+) + NADPH => (E)-pent-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937369", "l": "ATAD2 binds ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416516", "l": "GRK2 sequesters activated Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31812", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + viridiflorene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995334", "l": "COX15 transforms heme O to heme A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418456", "l": "cGMP is degraded by PDEs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65096", "l": "a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53418", "l": "8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009309", "l": "RUNX2 binds STUB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937682", "l": "RUNX1 binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604712", "l": "Initial activation of proMMP7 by trypsin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0071714", "l": "icosanoid transmembrane transporter activity", "d": ["Enables the transfer of icosanoids from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31394", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) <=> all-trans-4,4'-diapolycopene + 4 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14817", "l": "4-maleylacetoacetate = 4-fumarylacetoacetate", "d": [], "t": []}, {"i": "EC:5.2.1.2", "l": "\"maleylacetoacetate isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74504", "l": "H(+) + NADPH + yaequinolone D => H2O + NADP(+) + penigequinolone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635854", "l": "GLI2,3 are degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32797", "l": "ADP + H(+) + L-cysteine(in) + phosphate => ATP + H2O + L-cysteine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601887", "l": "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2870221", "l": "E-selectin binds E-selectin ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40885", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74992", "l": "deoxyerythrostominone(in) => deoxyerythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229283", "l": "LCNs bind lipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36575", "l": "(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61275", "l": "H2O + L-2-aminopentanoate + O2 <=> 2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089971", "l": "Secretion of collagens (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69671", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O = (2S)-naringenin + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42953", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42740", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.173", "l": "\"23S rRNA (guanine(2445)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53464", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47774", "l": "a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a guanosine in 21S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55636", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981610", "l": "Neuroglobin binds oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74098", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008930", "l": "methylthioadenosine nucleosidase activity", "d": ["Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166726", "l": "Activation of MASPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788611", "l": "HYKK phosphorylates 5HLYS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727349", "l": "XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002466", "l": "Formation of allysine by LOX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66070", "l": "H2O + kynurenate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23869", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA => acetyl-CoA + cyclohexanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004582", "l": "dolichyl-phosphate beta-D-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44490", "l": "3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75865", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14589", "l": "luteolin + S-adenosyl-L-methionine = chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70005", "l": "cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11206", "l": "AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.19", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16339", "l": "a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60916", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35163", "l": "H(+)(out) + minocycline(in) = H(+)(in) + minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870466", "l": "RGGT:CHM binds RABs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700171", "l": "Active ALK phosphorylates PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15052", "l": "GDP-alpha-D-glucose + H2O <=> D-glucose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41314", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38185", "l": "19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47815", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55801", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40281", "l": "CoA + O-dodecanoyl-R-carnitine => (R)-carnitine + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034847", "l": "naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61432", "l": "(R)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.123", "l": "\"7-epi-iridoid synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.21", "l": "\"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41830", "l": "(2E)-hexenoyl-[ACP] + H2O => (3R)-hydroxyhexanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.219", "l": "\"demethoxycurcumin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615571", "l": "PTEN mRNA translation is inhibited by miR-137 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656893", "l": "OPN1MW binds 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944215", "l": "Association of procollagen type XX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58377", "l": "decan-1-ol + NADP(+) => decanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12382", "l": "L-alanine + L-aspartate 4-semialdehyde => L-2,4-diaminobutanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48345", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose => a D-galactosylceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865320", "l": "CBFB binds RUNX1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724685", "l": "IgE binds omalizumab (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35122", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35224", "l": "2-oxo-dADP + H2O => 2-oxo-dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75956", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + oripavine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38092", "l": "delta-tocotrienol + S-adenosyl-L-methionine => beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615910", "l": "SUMOylation of PCNA with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19940", "l": "glycine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797974", "l": "LRRTMs bind NRXNs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74251", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74921", "l": "a (2E)-enoyl-[ACP] + AMP + H(+) => a (2E)-2-fatty-enoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102163", "l": "3-hydroxyacyl-CoA-acyl carrier protein transferase activity", "d": ["Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66876", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26514", "l": "cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.11", "l": "\"cyclohexane-1,2-dione hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193669", "l": "TRAF6 binds to p75NTR:NRIF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68349", "l": "ATP + GTP => diphosphate + pppA(2'-5')pG", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013023", "l": "RHOB GEFs activate RHOB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047934", "l": "glucose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36146", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH <=> hexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19717", "l": "H(+) + L-phenylalanine = 2-phenylethylamine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.53", "l": "\"phenylalanine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700120", "l": "PTN and MDK bind to PTPRZ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65275", "l": "chrodrimanin C + H(+) + NADPH + O2 <=> chrodrimanin H + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31006", "l": "(S)-2,3-epoxysqualene <=> germanicol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034577", "l": "N-isopropylacetaniline monooxygenase activity", "d": ["Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15109", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.126", "l": "\"2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54209", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55033", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine => an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62129", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP => a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004932", "l": "mating-type factor pheromone receptor activity", "d": ["Combining with a mating-type factor pheromone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65688", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56169", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28946", "l": "glycine betaine(in) <=> glycine betaine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59620", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine = 4-aminobutanoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187506", "l": "Translocation of p27 to the nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0000026", "l": "alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57713", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211960", "l": "CYP2U1 19-hydroxylates ARA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33734", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18871", "l": "ADP + H(+) + L-xylulose 5-phosphate => ATP + L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43040", "l": "hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0044374", "l": "sequence-specific DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36861", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611852", "l": "ADRB3 bind ADR,NAd (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964759", "l": "Alternative endo-mannosidase I route (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103111", "l": "D-glucosamine PTS permease activity", "d": ["Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine = D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467794", "l": "Resolution of sister chromatids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47588", "l": "a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613497", "l": "Unwinding DNA for the nascent transcript (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11372", "l": "ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine", "d": [], "t": []}, {"i": "EC:6.3.1.1", "l": "\"aspartate--ammonia ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36722", "l": "hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosenoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.683039265630129", "identifiers": [{"i": "GO:0071855", "l": "neuropeptide receptor binding", "d": ["Binding to a neuropeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20953", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052618", "l": "coenzyme F420-0:L-glutamate ligase activity", "d": ["Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73384", "l": "thiamine diphosphate(in) + thiamine phosphate(out) => thiamine diphosphate(out) + thiamine phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013567", "l": "HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.3", "l": "\"dephospho-[reductase kinase] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46873", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162715", "l": "Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028526", "l": "NR1H2 or NR1H3, NRIP1 bind the SCD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10361", "l": "3,4-dihydrocoumarin + H2O => 3-(2-hydroxyphenyl)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956568", "l": "RUNX1 binds the core TAL1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64690", "l": "3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77373", "l": "[alpha-N-acetylneuraminyl-(2->8)](n+1)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+) => [alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.534762107606241", "identifiers": [{"i": "GO:0004714", "l": "transmembrane receptor protein tyrosine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48022", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose => a globoside Gb3Cer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27594", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.85", "l": "\"all-trans-nonaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44358", "l": "methyl nogalonate => nogalaviketone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62095", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955844", "l": "RBKS phosphorylates ribose to R5P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371422", "l": "ATP hydrolysis by HSP70 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22672", "l": "2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.103", "l": "\"presqualene diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75815", "l": "ATP + H2O + K(+)(in) = ADP + H(+) + K(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592240", "l": "Formation of NRF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247922", "l": "GGCT transforms gGluCys to OPRO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74693", "l": "4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine => 2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61653", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0047606", "l": "hydroxynitrilase activity", "d": ["Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70831", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40010", "l": "(+)-copalyl diphosphate + H2O <=> (+)-copalol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102415", "l": "quercetin gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose = quercetin-3-gentiotrioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14878", "l": "ATP + L-glutamate => ADP + L-glutamyl 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106166", "l": "spindle pole body-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047534", "l": "2-acetolactate mutase activity", "d": ["Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447030", "l": "NrCAM binds Ankyrin-G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37717", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58732", "l": "5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33423", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.196", "l": "\"protein-N(pi)-phosphohistidine--N,N'-diacetylchitobiose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371527", "l": "HSF1 trimer translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700171", "l": "Active ALK phosphorylates PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56713", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] => H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47691", "l": "cis-4-hydroxy-L-proline + NADP(+) <=> Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59989", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) => cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944078", "l": "EGR1 binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873946", "l": "OTUD3 deubiquitinates PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44365", "l": "2-epi-5-epi-valiolone + ATP => 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58694", "l": "FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75180", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-axinyssene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37183", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29729", "l": "acetaldehyde + FMN + 2 H(+) + H2O + sulfite => ethane-1-sulfonate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835189", "l": "NCK1 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417820", "l": "P2Y9 receptor can bind to LPA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75081", "l": "Formation of AT-AC B Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24747", "l": "L-methionine => 2-aminobut-2-enoate + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57169", "l": "(R)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163090", "l": "Elongation Of The Telomeric Chromosome End (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186786", "l": "Autophosphorylation of PDGF beta receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982775", "l": "Growth hormone receptor dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420131", "l": "The PACAP receptor binds PACAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55965", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434004", "l": "viral dsRNA binds the toll-like receptor 3 (TLR3) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62206", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + propanal => 1-propanol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69033", "l": "N,N-dihydroxy-L-aspartate => (2S)-2-nitrosobutanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13601", "l": "cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.104", "l": "\"4-oxoproline reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22902", "l": "diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38678", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.-.-", "l": "\"Nitrogen-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102517", "l": "oleate 12-hydroxylase activity", "d": ["Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52812", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56727", "l": "AH2 + all-trans-beta-carotene + O2 <=> 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55676", "l": "chorismate + NH4(+) = (2S)-2-amino-4-deoxychorismate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38116", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol => 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73840", "l": "ATP + H2O + phenol => AMP + 2 H(+) + phenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866851", "l": "CFTR transits to the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45410", "l": "dodecanoyl-CoA + NAD(+) => (2E)-dodecenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688456", "l": "MLKL binds FLOT1, FLOT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50417", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] => H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24076", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61074", "l": "(-)-(R)-19-O-acetyltabersonine + CoA => (-)-(R)-19-hydroxytabersonine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76705", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470010", "l": "Dimerization of STATs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034522", "l": "cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070907", "l": "histidine:histamine antiporter activity", "d": ["Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193656", "l": "p75NTR interacts with RIP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61586", "l": "5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27410", "l": "3 a menaquinone + protoporphyrinogen IX => 3 a menaquinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019964", "l": "type II interferon binding", "d": ["Binding to type II interferon, also known as interferon-gamma."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111930", "l": "Adenylate cyclase produces cAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51555", "l": "D-sorbitol + NADP(+) <=> H(+) + L-xylo-3-hexulose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69731", "l": "CoA + phenylacetyl-AMP = AMP + H(+) + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63587", "l": "2-deoxyecdysone 22-phosphate + H2O <=> 2-deoxyecdysone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944220", "l": "Association of procollagen type XXIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18622", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 => a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26217", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.144", "l": "\"abieta-7,13-diene hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191303", "l": "FDPS dimer transfers IPPP to GPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669158", "l": "NF2 binds PAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.115", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170986", "l": "Ral-GDS binds to Ras-GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10472", "l": "(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.32", "l": "\"2,3-dimethylmalate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295622", "l": "SPRY2 binds CBL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35586", "l": "2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40487", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339713", "l": "Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030507", "l": "spectrin binding", "d": ["Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54706", "l": "H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39024", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58934", "l": "5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+) => 4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16751", "l": "acetate + H(+) + phosphate => H2O + phosphonoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023173", "l": "Insulin secretory granule docks at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690494", "l": "RHOB translocates to the endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429497", "l": "SLP-76 stimulates PLC gamma 2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944497", "l": "PTEN mRNA translation is negatively regulated by microRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549322", "l": "OCT1 transports organic cations out of hepatic cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48691", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine <=> D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35422", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72103", "l": "Formation of pre-mRNPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68685", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374663", "l": "DCC interaction with Ezrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31589", "l": "(Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022897", "l": "proton-dependent peptide secondary active transmembrane transporter activity", "d": ["Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203700", "l": "eNOS translocation from Golgi to Caveolae (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20615", "l": "adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => 3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689000", "l": "AADAC deacetylates PHEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051021", "l": "GDP-dissociation inhibitor binding", "d": ["Binding to a GDP-dissociation inhibitor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42846", "l": "7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide => 6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22294", "l": "biphenyl-3,5-diol + 4 CO2 + 4 CoA => benzoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77360", "l": "2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine => 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40773", "l": "(20S)-ginsenoside F1 + D-glucose => (20S)-ginsenoside Rg1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11783", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.1", "l": "\"dipeptidyl-peptidase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047566", "l": "3-ketovalidoxylamine C-N-lyase activity", "d": ["Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23335", "l": "(2R)-3-phosphoglycerate + GTP <=> (2R)-3-phospho-glyceroyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49786", "l": "CoA + H(+) + taurochenodeoxycholate => chenodeoxycholoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027562", "l": "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19759", "l": "NH4(+) + oxaloacetate => (3R)-3-hydroxy-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849055", "l": "PTK6 binds ARHGAP35 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13725", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.157", "l": "\"glucosamine-1-phosphate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28452", "l": "N(6)-(D-psicosyl)-L-lysine(out) => N(6)-(D-psicosyl)-L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60389", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21523", "l": "2 Fe(III)-[cytochrome b1] + formate <=> CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31132", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56783", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76385", "l": "carnosine(in) + n H(+)(in) => carnosine(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37018", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74734", "l": "Re-integration of insulin receptor into plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27806", "l": "acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29163", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) = 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28754", "l": "sn-glycerol 3-phosphate + ubiquinone-8 <=> dihydroxyacetone phosphate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.9", "l": "\"nucleotide diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13968", "l": "H2O + L,L-cystathionine <=> L-homocysteine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59695", "l": "D-cellotriono-1,5-lactone + H2O <=> D-cellotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769014", "l": "NPAS4 stimulates GEM gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250880", "l": "botF HC:LC binds SV2A or B or C and GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014293", "l": "RAC2 GDIs block activation of RAC2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37328", "l": "ATP + H2O + L-methionyl-L-alanine(out) => ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029272", "l": "Release of PLCG from FCGR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806610", "l": "Keratin filament formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59833", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11277", "l": "4 hydroquinone + O2 => 4 benzosemiquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41952", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.118", "l": "\"[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47841", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine => (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21357", "l": "L-arabinitol + NAD(+) => H(+) + L-ribulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59073", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52176", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74319", "l": "O-acetyl-(R)-carnitine(in) = O-acetyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10901", "l": "an aromatic L-alpha-amino acid + glyoxylate => an aromatic oxo-acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35186", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O <=> 4-carboxy-2-thioxobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28643", "l": "(2E,6E)-farnesyl diphosphate = alpha-zingiberene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.65", "l": "\"zingiberene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625416", "l": "Anterograde IFT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63300", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36542", "l": "hexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22070", "l": "(2S)-2-acetolactate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24502", "l": "ATP + H(+) + phosphate => adenosine 5'-tetraphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39668", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53074", "l": "2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46545", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420724", "l": "CASR binds Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32198", "l": "abieta-7,13-dien-18,18-diol <=> abieta-7,13-dien-18-al + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19767", "l": "3-hydroxypropanal + H2O => glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805470", "l": "AMPK phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60609", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68515", "l": "(2Z,6Z)-farnesyl diphosphate <=> alpha-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12995", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51724", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57833", "l": "5-oxopentanoate + H2O + NADP(+) => glutarate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163069", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216061", "l": "SPP1 (osteopontin) binds integrin alpha8beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69316", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694428", "l": "LMAN family proteins bind glycosylated cargo (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70976", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) => 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701064", "l": "TRPV1 binds TRPV1 agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68587", "l": "ATP + H2O + L-tryptophan(out) <=> ADP + H(+) + L-tryptophan(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140897", "l": "mechanoreceptor activity", "d": ["Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31257", "l": "3-hydroxy-3-methyl-2-oxobutanoate => (2S)-2-acetolactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404142", "l": "atROL binds RBP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77363", "l": "2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106363", "l": "protein-cysteine methyltransferase activity", "d": ["Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:66544", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981622", "l": "Myoglobin:oxygen dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29223", "l": "menaquinone-8 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31003", "l": "(S)-2,3-epoxysqualene = germanicol", "d": [], "t": []}, {"i": "EC:5.4.99.34", "l": "\"germanicol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28141", "l": "H2O + streptothricin F <=> streptothricin F acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718360", "l": "GNRHR binds GNRHR peptide agonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390886", "l": "HRH4 binds Hist (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517846", "l": "TLR2-1 :TLR1-1 binds to triacyl lipopeptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57985", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730483", "l": "SARS-CoV-2 nsp16 binds to U1 snRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222485", "l": "TrxB reactivates TrxA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030763", "l": "isobutyraldoxime O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27380", "l": "(R)-glycerate + ATP <=> (2R)-2-phosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75720", "l": "CoA-disulfide + H2O => 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41678", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220967", "l": "p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0099530", "l": "G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential", "d": ["A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51151", "l": "a primary alcohol + 2 oxidized [azurin] <=> an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.202", "l": "\"2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195726", "l": "Association of  NA into rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008115", "l": "sarcosine oxidase activity", "d": ["Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047026", "l": "androsterone dehydrogenase (A-specific) activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47822", "l": "9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372819", "l": "PCK2 phosphorylates OA to yield PEP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707659", "l": "Hemes:LY96 activates TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72749", "l": "leukotriene E4(in) => leukotriene E4(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070326", "l": "very-low-density lipoprotein particle receptor binding", "d": ["Binding to a very-low-density lipoprotein receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103056", "l": "gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate = gibberellin A44 diacid + carbon dioxide + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29415", "l": "(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73718", "l": "UBF-1 Binds rDNA Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5246478", "l": "APOM binds retinoids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71650", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA <=> a medium-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48323", "l": "a ganglioside GA1 + GDP-beta-L-fucose <=> a ganglioside Fuc-GA1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63193", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 => glycine betaine + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49190", "l": "a 3-vinylbacteriochlorophyllide d + H2O => a bacteriochlorophyllide d", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707594", "l": "Hemes bind LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163418", "l": "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114284", "l": "Release of Cytochrome c from mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33209", "l": "ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate => ATP + H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10147", "l": "a ribonucleoside 3'-phosphate + H2O <=> a ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57310", "l": "diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => CTP + H(+) + N(5)-phospho-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700658", "l": "ceritinib-resistant ALK mutants don't bind ceritinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688456", "l": "MLKL binds FLOT1, FLOT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55492", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54466", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77068", "l": "H2O + NADP(+) + pentylamine => H(+) + NADPH + NH4(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700981", "l": "TP53 family members bind the BAX promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016159", "l": "muconolactone delta-isomerase activity", "d": ["Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016422", "l": "mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60721", "l": "(E)-hept-2-enal + H2O + NADP(+) => (E)-hept-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690152", "l": "USP5 cleaves polyubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12673", "l": "an aliphatic amide = a nitrile + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.84", "l": "\"nitrile hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427570", "l": "Group 3 - Selective Cl- transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008871", "l": "aminoglycoside 2''-nucleotidyltransferase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68862", "l": "7beta-25-dihydroxycholesterol + NADP(+) => 7-oxo-25-hydroxycholesterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047505", "l": "(-)-menthol monooxygenase activity", "d": ["Catalysis of the reaction: (-)-menthol + H+ + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71144", "l": "3-hydroxyhispidin + O2 => (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74901", "l": "(2E)-butenoyl-[ACP] + AMP + diphosphate => (2E)-2-butenoate + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.7.-.-", "l": "\"Carbon-phosphorus lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003743", "l": "translation initiation factor activity", "d": ["Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672948", "l": "MARK3 phosphorylates KSR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30229", "l": "dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+) => dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45312", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018828", "l": "halohydrin hydrogen-halide-lyase A activity", "d": ["Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005146", "l": "leukemia inhibitory factor receptor binding", "d": ["Binding to an leukemia inhibitory factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10243", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34608", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine => a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211247", "l": "Cleavage of DNA by DFF40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694287", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59628", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine = 4-aminobutanoate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532678", "l": "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034039", "l": "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity", "d": ["Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106356", "l": "4-hydroxybenzoate 3-monooxygenase [NADPH] activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+."], "t": []}, {"i": "RHEA:19477", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420128", "l": "SRC-1 phosphorylates SHB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56317", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA => 3-acetylamino-4-hydroxybenzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65736", "l": "2-oxoglutarate + O2 + octyl sulfate = CO2 + H(+) + octanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018785", "l": "RHOBTB2 binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57907", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013020", "l": "Activation of GIRK/Kir3 Channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4411373", "l": "NLK translocates to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53899", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59957", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate => a nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000901", "l": "translation repressor activity, non-nucleic acid binding", "d": ["Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40739", "l": "(20S)-ginsenoside Rb2 + 2 H2O = (20S)-ginsenoside C-Y + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58440", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008754", "l": "O antigen ligase activity", "d": ["Catalysis of the reaction: Lipid A-core + colanic acid = MLPS."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37931", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866277", "l": "AP-2 directly binds some endocytic cargo (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56395", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821486", "l": "HCFC1 binds SET1A complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44136", "l": "dodecanoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22367", "l": "L-quinate + NAD(+) <=> 3-dehydroquinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52423", "l": "O-phospho-L-serine + thiosulfate <=> phosphate + S-sulfo-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15250", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose => 1-O-galloyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396347", "l": "NOTCH1 Coactivator Complex binds HES1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840488", "l": "PSAP(195-273) forms a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106266", "l": "3-chloro THPH synthase activity", "d": ["Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O."], "t": []}, {"i": "RHEA:64356", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169719", "l": "Secreted CD14 binds LPS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56901", "l": "a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine => a globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.13", "l": "\"IgA-specific metalloendopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53133", "l": "A + a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(1,4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70641", "l": "2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29066", "l": "a menaquinone + formate + H(+) <=> a menaquinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34293", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13234", "l": "guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43992", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 = 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72594", "l": "D-glucuronate(out) + H(+)(out) <=> D-glucuronate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507871", "l": "Aquaporins passively transport glycerol out of cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109639", "l": "Formation of the closed pre-initiation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73736", "l": "O2 + trans-resveratrol => 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24675", "l": "ATP + cytidine => ADP + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362522", "l": "ALDHs oxidise atRAL to atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0008381", "l": "mechanosensitive monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress."], "t": []}, {"i": "TCDB:1.A.23.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095889", "l": "MMACHC dealkylates RCbl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58390", "l": "4-amino-3-all-trans-hexaprenylbenzoate + diphosphate => 4-aminobenzoate + all-trans-hexaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46605", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate => [HPr protein]-L-serine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102901", "l": "isopimaradienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 = isopimaradiene-diol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77506", "l": "3-phenylpropanal + hydrogen cyanide <=> (2S)-2-hydroxy-4-phenylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39708", "l": "a long-chain fatty acyl-CoA(out) => a long-chain fatty acyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.-.-", "l": "\"Isomerases altering macromolecular conformation\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58980", "l": "citral + H2O + O2 = 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647632", "l": "CASP3 cleaves GSDME (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050342", "l": "tocopherol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035804", "l": "structural constituent of egg coat", "d": ["The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45010", "l": "octadecanoate + sphinganine => H2O + N-(octadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23209", "l": "acetyl-CoA + trans-glutaconate => (2E)-glutaconyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734730", "l": "ORC1 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75520", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 => (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112437", "l": "Formation of NELF complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005415", "l": "nucleoside:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741411", "l": "CYLD deubiquitinates NEMO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434003", "l": "LPS binding to CD14 co-receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663511", "l": "BIL binds GSTA1, FABP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50633", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30486", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47179", "l": "(2R)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39140", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70721", "l": "L-alanine(out) => L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47258", "l": "6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696457", "l": "BDH2 dehydrogenates 3HBA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016710", "l": "trans-cinnamate 4-monooxygenase activity", "d": ["Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821486", "l": "HCFC1 binds SET1A complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24452", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.80", "l": "\"protein-glutamate O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71521", "l": "uridine(in) => uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41363", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38442", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421201", "l": "inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803871", "l": "TP53 stimulates SFN expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46666", "l": "5beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61771", "l": "rebaudioside A + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034511", "l": "U3 snoRNA binding", "d": ["Binding to a U3 small nucleolar RNA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73504", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine => 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60684", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) = (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706298", "l": "Active FLT3 binds to CSK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71205", "l": "L-homoarginine(out) => L-homoarginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28662", "l": "beta-lactose + H2O <=> beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534260", "l": "E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39032", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54886", "l": "H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57117", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45771", "l": "gamma-L-glutamyl-L-alaninol + H2O <=> L-alaninol + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001139", "l": "RNA polymerase II complex recruiting activity", "d": ["Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49186", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol => chlorophyllide a + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48180", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50422", "l": "H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59316", "l": "D-cellobiose + O2 = D-cellobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517674", "l": "p-S158,221-HuR binds mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853801", "l": "PSPN binds RET:GFRA4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60386", "l": "N-(2,3-dihydroxybenzoyl)-L-serine trimer => enterobactin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55727", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37895", "l": "H2O + protodioscin = 26-deglucoprotodioscin + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.186", "l": "\"protodioscin 26-O-beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58447", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804266", "l": "CHEK2 phosphorylates TTC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0019865", "l": "immunoglobulin binding", "d": ["Binding to an immunoglobulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66667", "l": "ATP + coproporphyrin III(in) + H2O <=> ADP + coproporphyrin III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71873", "l": "(S)-3-hydroxybutanoate(in) + H(+)(in) => (S)-3-hydroxybutanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46142", "l": "(22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54192", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61976", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47803", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59704", "l": "D-cellohexaono-1,5-lactone + H2O = D-cellohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20744", "l": "NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.196", "l": "\"15-hydroxyprostaglandin-D dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76140", "l": "D-gluconate(in) => D-gluconate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14531", "l": "ADP-D-ribose + phosphate => ADP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21010", "l": "diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH => diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19803", "l": "3'-dephospho-CoA + diphosphate => (R)-4'-phosphopantetheine + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196017", "l": "Dynamin is recruited to the gap junction plaque (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18529", "l": "3-methylbutanol + NAD(+) = 3-methylbutanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75047", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034794", "l": "cyclopropanecarboxyl-CoA decyclase activity", "d": ["Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68257", "l": "L-cystine(in) + Na(+)(in) => L-cystine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033850", "l": "Z-farnesyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106317", "l": "methane monooxygenase NADH activity", "d": ["Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179413", "l": "Activated PKC-alpha  activate MMP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736970", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73762", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39758", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44535", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047052", "l": "(S)-stylopine synthase activity", "d": ["Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33946", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62652", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20320", "l": "L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43068", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.126", "l": "\"beta-amyrin 28-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016231", "l": "beta-N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52978", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0003984", "l": "acetolactate synthase activity", "d": ["Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21133", "l": "H2O + O2 + xanthine => H2O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700156", "l": "Active ALK dimer binds IRS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49729", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NADP(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032448", "l": "DNA hairpin binding", "d": ["Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44235", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794351", "l": "SHARPIN binds SHANK proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67846", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23098", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+) => 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37124", "l": "sphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28536", "l": "diphosphate + dTMP + H(+) => dTTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18651", "l": "2-dehydro-3-deoxy-D-galactonate + H2O => D-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47845", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22780", "l": "(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58383", "l": "NADP(+) + nonan-1-ol <=> H(+) + NADPH + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.5", "l": "\"chondroitin AC lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44625", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64718", "l": "acrolein + H(+) + NADPH => NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213207", "l": "Formation of collagen networks (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54929", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69071", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline <=> A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44383", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043237", "l": "laminin-1 binding", "d": ["Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64901", "l": "H2O + UTP => H(+) + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221061", "l": "TDG excises 5-carboxylcytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27356", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199298", "l": "AKT phosphorylates CREB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604732", "l": "Autocatalytic activation of proMMP13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77689", "l": "a ganglioside GalNAc-GD1a (d18:1(4E)) + H(+) + UDP => a ganglioside GD1a (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138459", "l": "WNT5A:FZD4 is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67168", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine = 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451347", "l": "Activation of JNK by DSCAM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12770", "l": "A + D-gluconate => 2-dehydro-D-gluconate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52731", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate <=> a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66638", "l": "(-)-alpha-acorenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009282", "l": "CDK1 phosphorylates RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018747", "l": "RHOQ GEFs activate RHOQ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.11", "l": "\"cholesterol-5,6-oxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74059", "l": "beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57809", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13551", "l": "diphosphate + GDP-beta-L-fucose => beta-L-fucose 1-phosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21114", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose => a globoside Gb3Cer (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-984606", "l": "Kinesin-5 is a homotetramer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483089", "l": "PE is converted to PS by PTDSS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610741", "l": "PKA phosphorylates GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20781", "l": "ATP + GMP => ADP + GDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.17", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193665", "l": "MYD88 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61707", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine <=> AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674018", "l": "BRAP binds RAS:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1370500", "l": "PRLR binds SCF beta-TrCP complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646685", "l": "Aggresome dissociates from dynein and microtubule (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65048", "l": "4-acetoxybenzyl alcohol + NAD(+) = 4-acetoxybenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61089", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 => (2R,3R)-dihydroquercetin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68038", "l": "(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+) => (S)-cystathionine ketimine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55896", "l": "chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.58", "l": "\"tryptophan 5-halogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77144", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731123", "l": "Syndecan-1 binds Integrin alphaVbeta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64110", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15982", "l": "H(+) + S-adenosyl-L-methionine => CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59881", "l": "4-hydroxyphenylacetate + FMNH2 + O2 => 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50630", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417898", "l": "P2Y4 receptor can bind to UTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53134", "l": "a 3-oxo-Delta(1,4)-steroid + AH2 => A + a 3-oxo-Delta(4)-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419843", "l": "CALCA(83-119) binds CALCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14076", "l": "3-hydroxy-L-glutamate + H(+) <=> 4-amino-3-hydroxybutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35892", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592436", "l": "Initial activation of proMMP9 by MMPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34800", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71913", "l": "cholate(in) + 2 Na(+)(in) => cholate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48879", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45385", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008043", "l": "MAPK8 phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070513", "l": "death domain binding", "d": ["Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76031", "l": "2 H2O2 => O2 + 2 H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102932", "l": "pterocarpan reductase activity", "d": ["Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247849", "l": "WLS dissociates from retromer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21861", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43422", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38639", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380199", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44406", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-7 => 3-demethylubiquinol-7 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614271", "l": "Autocleavage of ADGRG6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65040", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76630", "l": "(S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59218", "l": "CO2 + skatole => (indol-3-yl)acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106059", "l": "tRNA (cytidine(56)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694442", "l": "CNIH2,3 bind GRIA1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4837364", "l": "Secretion of SOD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54871", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH <=> butanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25727", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13581", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.17", "l": "\"UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45842", "l": "3-oxodecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41764", "l": "a ganglioside GD3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55689", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36010", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38190", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10365", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O => (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15115", "l": "5alpha-cholestane-3beta,5,6beta-triol => 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63055", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43408", "l": "sphinganine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40253", "l": "10-carboxy-13-deoxydaunorubicin + H(+) + methanol => 4-O-methylrhodomycin D + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11996", "l": "biphenyl-2-ol + H(+) + NADH + O2 = biphenyl-2,3-diol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30362", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 <=> chlorophyllide b + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618107", "l": "ATP binding to HSP90 triggers conformation change (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29147", "l": "2 H(+)(in) + nitrate + ubiquinol-8 = 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74963", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) = L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53326", "l": "2-glyceryl-prostaglandin E2 => 2-glyceryl-prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000433", "l": "SUMOylation of PML with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350359", "l": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008817", "l": "corrinoid adenosyltransferase activity", "d": ["Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58954", "l": "(20S)-ginsenoside Rh1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24441", "l": "ATP + H2O + phosphate(out) => ADP + H(+) + 2 phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53279", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029983", "l": "Dimerization of FGFR2 ligand-independent mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46766", "l": "a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14101", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.29", "l": "\"deoxyhypusine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41184", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22191", "l": "an (R)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823816", "l": "OPTN binds CASP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018598", "l": "hydroxymethylsilanetriol oxidase activity", "d": ["Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196964", "l": "RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850786", "l": "SPINK6 binds KLK12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047895", "l": "formaldehyde dismutase activity", "d": ["Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800315", "l": "MST1 binds MST1R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693111", "l": "RHOF auto-activates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690494", "l": "RHOB translocates to the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050447", "l": "zeatin 9-aminocarboxyethyltransferase activity", "d": ["Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928645", "l": "EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13125", "l": "CoA + glutathione disulfide = CoA-glutathione + glutathione", "d": [], "t": []}, {"i": "EC:1.8.4.3", "l": "\"glutathione--CoA-glutathione transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663264", "l": "RORA, EP300 bind CPT1A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30296", "l": "GTP + pyruvate => GDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33095", "l": "chorismate + inosine + phosphoenolpyruvate = futalosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16323", "l": "H(+) + indan-1-one + NADPH => (S)-indan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59891", "l": "4-chloro-L-lysine + AH2 + O2 <=> A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70892", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) => L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796617", "l": "MIB2 binds CFLAR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191636", "l": "Phosphorylation of Cx43 by c-src (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76894", "l": "2-hydroxy-1-phenylethan-1-amine + H2O + NAD(+) <=> 2-hydroxyacetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139920", "l": "Translocation of tBID to mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32231", "l": "(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34379", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": [], "t": []}, {"i": "EC:2.4.1.287", "l": "\"rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433418", "l": "Phosphorylation of JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29102", "l": "a menaquinone + 5 H(+)(in) + NADH <=> a menaquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19479", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 4-hydroxybenzoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69317", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11624", "l": "2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.3.1", "l": "\"oximinotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71076", "l": "L-arginine(in) + L-cystine(out) => L-arginine(out) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12832", "l": "(2S,3S)-3-methyl-L-aspartate <=> mesaconate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710306", "l": "GSDME expression mediated by TP53, TP63 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61242", "l": "3-phenylpyruvate + H2O2 + NH4(+) => H2O + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64174", "l": "galactarate => L-altrarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58892", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": [], "t": []}, {"i": "EC:2.8.2.40", "l": "\"omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52346", "l": "(24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043912", "l": "D-lysine oxidase activity", "d": ["Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004552", "l": "octanol dehydrogenase activity", "d": ["Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65430", "l": "deamido-NAD(+)(out) + NAD(+)(in) => deamido-NAD(+)(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55690", "l": "1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22461", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042556", "l": "eukaryotic elongation factor-2 kinase regulator activity", "d": ["Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701557", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692437", "l": "ANG binds F-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n2", "l": "\"argonaute-2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67068", "l": "AH2 + chermesin D methyl ester = A + asnovolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848606", "l": "PTK6 phosphorylates PXN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67027", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23590", "l": "oxalyl-CoA + succinate => oxalate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604763", "l": "Autocatalytic activation of MMP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10465", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O => n acetate + chitosan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673322", "l": "p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77166", "l": "H(+) + hercynine + N-acetyl-1-seleno-beta-D-glucosamine + O2 <=> H2O + hercynyl-SeGlcNAc selenoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44791", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine <=> H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48457", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191784", "l": "snRNA Cap hypermethylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53013", "l": "2,5-dichlorohydroquinone + 2 glutathione => chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29392", "l": "GTP + H2O => diphosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170986", "l": "Ral-GDS binds to Ras-GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36241", "l": "1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948027", "l": "RNASEs bind bacterial phospholipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57894", "l": "a quinol + 4 H(+)(out) + NADP(+) => a quinone + 5 H(+)(in) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72554", "l": "glutarate(out) + urate(in) <=> glutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839064", "l": "YME1L1 binds mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0003720", "l": "telomerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58772", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321805", "l": "NSL acetylates histone H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852716", "l": "Thrombin, ELANE cleave C5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43240", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46014", "l": "a quinol + oxaloacetate => (S)-malate + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59213", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP => AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16984", "l": "3-oxoadipate + NAD(+) <=> H(+) + maleylacetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30800", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57789", "l": "1,3-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69248", "l": "H2O + sinigrin = (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23315", "l": "2 sucrose <=> 1(F)-beta-D-fructosylsucrose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030731", "l": "guanidinoacetate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57617", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O => dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938981", "l": "IL3 gene transcription is stimulated by RUNX1 and ELF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.24", "l": "\"candidapepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0003845", "l": "11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59105", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate => a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24695", "l": "(E)-isoeugenol + acetate + NADP(+) => (E)-coniferyl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33144", "l": "galactitol(in) => galactitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74053", "l": "D-threonine(in) + L-alanine(out) => D-threonine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32382", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) <=> (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29403", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 = 3-demethylubiquinol-8 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59156", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55462", "l": "11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034868", "l": "2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018511", "l": "2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ = 2,3-dihydroxy-p-cumate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12062", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O => acetyl-CoA + 5 H(+) + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48769", "l": "ATP + D-erythrulose => ADP + D-erythrulose 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30879", "l": "H2O + NAD(+) + prop-2-ynal = 2 H(+) + NADH + propynoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33462", "l": "H(+) + NADPH + zymosterone <=> NADP(+) + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662606", "l": "MT3 binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45042", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl => 2 Fe(III)-[cytochrome c] + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805426", "l": "CARD8 binds CASP9(1-416) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676268", "l": "Formation of the MLL4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72690", "l": "all-trans-retinol(out) <=> all-trans-retinol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102050", "l": "indole-3-acetyl-tyrosine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) = H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034559", "l": "bisphenol A hydroxylase B activity", "d": ["Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671772", "l": "p-T38-PPP1R14A binds MLCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.1", "l": "\"cystathionine gamma-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847880", "l": "CYTH proteins bind ARF1:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928615", "l": "EFNBs bind SFKs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876868", "l": "ECE1 cleaves EDN1(53-90) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22843", "l": "D-glutamine + H2O <=> D-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62327", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60833", "l": "a 5'-end triphospho-guanosine in mRNA + H2O => a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24218", "l": "(2E,6E)-farnesoate + 2 H(+) + NADH => (2E,6E)-farnesal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69545", "l": "ATP + streptidine => 6-O-adenylylstreptidine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167686", "l": "Active PLCG1 hydrolyses PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56148", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53650", "l": "(+)-corvol ether A + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31382", "l": "H2O + pyrrole-2-carboxylate <=> 1H-pyrrole + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228840", "l": "Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15449", "l": "homogentisate + O2 = 4-maleylacetoacetate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.5", "l": "\"homogentisate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21502", "l": "H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71495", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627078", "l": "XIAP binds CASP9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34922", "l": "thiamine(in) <=> thiamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1370505", "l": "PRLR is phosphorylated at Ser-349 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10288", "l": "H2O + L-rhamnono-1,4-lactone = H(+) + L-rhamnonate", "d": [], "t": []}, {"i": "EC:3.1.1.65", "l": "\"L-rhamnono-1,4-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.164", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64077", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51176", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48354", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48397", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine => 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44733", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085992", "l": "SUMOylation of DAXX with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186785", "l": "PDGF-AA clevage by Furin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22842", "l": "D-glutamate + NH4(+) => D-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58060", "l": "2-sulfinoacetaldehyde + H2O = acetaldehyde + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034736", "l": "cholesterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202328", "l": "Translocation of PKC theta to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17819", "l": "H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877902", "l": "Activated AR binds RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39539", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39667", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.1.98.5", "l": "\"secondary-alcohol dehydrogenase (coenzyme-F420)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051907", "l": "S-(hydroxymethyl)glutathione synthase activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045028", "l": "G protein-coupled purinergic nucleotide receptor activity", "d": ["Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018833", "l": "DDT-dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851888", "l": "MET binds SHC1-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55728", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17438", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate => (2E,4E)-2,4-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48793", "l": "GDP-beta-L-fucose + Lc4Cer => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080072", "l": "spermidine:sinapoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030377", "l": "urokinase plasminogen activator receptor activity", "d": ["Combining with the urokinase plasminogen activator to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19943", "l": "coclaurine + H(+) + S-adenosyl-L-homocysteine => norcoclaurine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46578", "l": "2 H2O + NADP(+) + stigmasterol => H(+) + NADPH + O2 + sitosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2248891", "l": "M6PR transports activated ARSA to the lysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51986", "l": "all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10693", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 => H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164840", "l": "ADP and Pi bind to ATPase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74423", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15810", "l": "(2E)-geranyl diphosphate + H2O => (R)-linalool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617535", "l": "Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685195", "l": "SARS-CoV-1 9b recruits ITCH to MAVS  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606159", "l": "BTK autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29052", "l": "2 H(+)(in) + H2 + menaquinone-8 => 2 H(+)(out) + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046703", "l": "natural killer cell lectin-like receptor binding", "d": ["Binding to a lectin-like natural killer cell receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55332", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38368", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA => 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22306", "l": "5-dehydro-D-fructose + a ubiquinol => a ubiquinone + keto-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681987", "l": "LC3 is cleaved by ATG4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197690", "l": "Detachment of WASP/WAVE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120283", "l": "protein serine/threonine kinase binding", "d": ["Binding to a protein serine/threonine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610726", "l": "The IFT-A complex recruits TULP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22421", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) => 2 H(+) + maleylacetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14709", "l": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203774", "l": "Interaction of Csk with PAG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47914", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O => 6-deoxy-6-sulfo-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13253", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193832", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22150", "l": "a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin] => a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61652", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.71", "l": "\"2,3-dihydroxybenzoate--[aryl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46575", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620103", "l": "ALDH2 transforms GTN to NO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944262", "l": "Association of procollagen type X (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30892", "l": "O-acetyl-L-serine + thiosulfate => acetate + H(+) + S-sulfo-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73443", "l": "2-oxoglutarate + gardenin B + O2 = CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15079", "l": "(R)-pantetheine + CO2 => H(+) + N-[(R)-pantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25455", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50835", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099899", "l": "WNT5A binds FZD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12629", "l": "2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.11", "l": "\"hyoscyamine (6S)-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43170", "l": "inosine(34) in tRNA + NH4(+) => adenosine(34) in tRNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030339", "l": "fatty-acyl-ethyl-ester synthase activity", "d": ["Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052794", "l": "exo-alpha-(2->3)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016985", "l": "mannan endo-1,4-beta-mannosidase activity", "d": ["Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12887", "l": "GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) => GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70775", "l": "6-sulfo-D-quinovose + FMNH2 + O2 = 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}, {"i": "EC:1.14.14.181", "l": "\"sulfoquinovose monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835443", "l": "STAT1,STAT3 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19265", "l": "carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.108", "l": "\"carnitine 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11256", "l": "H2O + limonin + UDP-alpha-D-glucose = glucosyl-limonin + 2 H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.210", "l": "\"limonoid glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42311", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0051219", "l": "phosphoprotein binding", "d": ["Binding to a phosphorylated protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74239", "l": "phosphate + solabiose = alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}, {"i": "EC:2.4.1.389", "l": "\"solabiose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5606996", "l": "Soluble PROCR binds activated protein C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51775", "l": "dimethylallyl diphosphate + phlorisobutanophenone <=> 4-prenylphlorisobutanophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209840", "l": "Two DITs combine to form thyroxine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418850", "l": "Activation of Cdc42 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008782", "l": "adenosylhomocysteine nucleosidase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61709", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP => AMP + L-seryl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68339", "l": "(R)-4'-phosphopantetheine sulfonate + H2O <=> (R)-pantetheine sulfonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694274", "l": "mRNA1 is translated to pp1ab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12859", "l": "L-glutamate => (2S,3S)-3-methyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007462", "l": "CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13069", "l": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine", "d": [], "t": []}, {"i": "EC:2.7.1.82", "l": "\"ethanolamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140684", "l": "histone H3K9me2/H3K9me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35446", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose <=> an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31034", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15613", "l": "NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin", "d": [], "t": []}, {"i": "EC:1.3.1.76", "l": "\"precorrin-2 dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60089", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52581", "l": "ATP + H2O + Pb(2+)(in) => ADP + H(+) + Pb(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65420", "l": "GMP(in) + NAD(+)(out) = GMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31542", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624272", "l": "MMPs cleave HB-EGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46286", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102028", "l": "cystathionine gamma-synthase activity (acts on O-phosphohomoserine)", "d": ["Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41969", "l": "a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20898", "l": "ADP + H(+) + phosphate + urea-1-carboxylate => ATP + hydrogencarbonate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69173", "l": "Joining of adjacent Okazaki fragments (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165195", "l": "GTP loading by Rheb (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61188", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20344", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735268", "l": "GATA4 and NKX2-5 bind the HAND1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24104", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": [], "t": []}, {"i": "EC:2.4.2.29", "l": "\"tRNA-guanosine(34) preQ1 transglycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63662", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+) => (8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52645", "l": "D-xylono-1,4-lactone 5-phosphate + H2O => 5-phospho-D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12275", "l": "H(+) + L-dopa <=> CO2 + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43903", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15381", "l": "O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": [], "t": []}, {"i": "EC:1.13.11.24", "l": "\"quercetin 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10952", "l": "(E)-sinapoyl-CoA + hydroxymalonate = (E)-sinapoyltartronate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.106", "l": "\"tartronate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22915", "l": "L-valine + pyruvate <=> 3-methyl-2-oxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713837", "l": "Psoralens in combination with UV generate DNA interstrand crosslinks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034801", "l": "2,4-dinitrocyclohexanone hydrolase activity", "d": ["Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692550", "l": "Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051992", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31458", "l": "NAD(+) + reduced riboflavin <=> 2 H(+) + NADH + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40036", "l": "ATP + L-glutamate + N-acetyl-L-aspartate => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77058", "l": "cyclopentylamine + H2O + NADP(+) <=> cyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31235", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.23", "l": "\"4-hydroxyglutamate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19357", "l": "H(+) + L-proline betaine + NADPH + O2 = formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48415", "l": "a globoside IV3GalNAc-Gb4Cer + H2O <=> a globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432825", "l": "HMGB1 binds TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420121", "l": "SFKs phosphorylate PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663752", "l": "KCNN2 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11914", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450074", "l": "Interleukin-3 receptor alpha subunit binds Interleukin-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28746", "l": "nitrate(in) + nitrite(out) <=> nitrate(out) + nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52874", "l": "17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50463", "l": "a medium chain fatty acid + ATP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40982", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17104", "l": "H2O + O-acyl-(R)-carnitine <=> (R)-carnitine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36088", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9842115", "l": "PSAP(195-273) dimer binds PE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016826", "l": "hydrolase activity, acting on acid sulfur-nitrogen bonds", "d": ["Catalysis of the hydrolysis of any acid sulfur-nitrogen bond."], "t": []}, {"i": "EC:3.10.-.-", "l": "\"Acting on sulfur-nitrogen bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41944", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": [], "t": []}, {"i": "EC:2.7.2.17", "l": "\"[amino-group carrier protein]-L-2-aminoadipate 6-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334794", "l": "FABPs bind LCFAs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36394", "l": "cholesterol + NADP(+) <=> desmosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67423", "l": "a glycerophospholipid + H2O <=> a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60228", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22337", "l": "glycine betaine + L-homocysteine => L-methionine + N,N-dimethylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54448", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.29", "l": "\"peptidyl-tRNA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003962", "l": "cystathionine gamma-synthase activity", "d": ["Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28058", "l": "L-lyxopyranose = L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39996", "l": "an N-acylethanolamine + H2O => a fatty acid + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047050", "l": "(S)-2-hydroxy-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60645", "l": "3'-phosphoadenylyl sulfate + androsterone => adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61120", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17794", "l": "H2O + L-alanyl-tRNA(Thr) => H(+) + L-alanine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36408", "l": "ATP + hydrogencarbonate + L-threonine => diphosphate + H2O + L-threonylcarbamoyladenylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050292", "l": "steroid 9-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15930", "l": "2 H(+) + 2 H2O + methylenediurea => CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35369", "l": "isoheptadecanoyl-coA + NADP(+) => (2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47820", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685953", "l": "SIRT6 deacetylates RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38749", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111264", "l": "Addition of nucleotides between position +11 and +30 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53988", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785860", "l": "Expression of SOCS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14004", "l": "choloyl-CoA + glycine <=> CoA + glycocholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018731", "l": "1-oxa-2-oxocycloheptane lactonase activity", "d": ["Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672978", "l": "RAF phosphorylates MAP2K dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34022", "l": "a 1-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56955", "l": "CTP + pyruvate <=> CDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21922", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001532", "l": "interleukin-21 receptor activity", "d": ["Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102550", "l": "2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029471", "l": "Hydrolysis of PC to PA by PLD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34400", "l": "9-cis-beta-carotene + O2 => 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047619", "l": "acylcarnitine hydrolase activity", "d": ["Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225961", "l": "Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981355", "l": "RASA1 binds RAS:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47002", "l": "NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996727", "l": "REST recruits the BHC complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31595", "l": "(Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790905", "l": "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051735", "l": "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54765", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693250", "l": "RHOD binds effectors at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120160", "l": "intraciliary transport particle A binding", "d": ["Binding to an intraciliary transport particle A (IFT A) complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623096", "l": "Delayed Early (DE) Gene Expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71212", "l": "chlorate(out) + 2 Na(+)(out) => chlorate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68590", "l": "(6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+) => (6R)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40714", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102468", "l": "wogonin 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75856", "l": "Abortive Initiation Before Second Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34972", "l": "Fe(3+)(in) => Fe(3+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444647", "l": "C3a receptor binds anaphylatoxin C3a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625029", "l": "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655824", "l": "Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72161", "l": "glutarate(out) + taurocholate(in) => glutarate(in) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30474", "l": "(2Z,6Z)-farnesyl diphosphate <=> (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944257", "l": "Association of procollagen type XXIV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018594", "l": "MECP2 binds LBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44959", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH <=> hexanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050134", "l": "N6-methyl-lysine oxidase activity", "d": ["Catalysis of the reaction: N(6)-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607744", "l": "MALT1 binds BCL10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851114", "l": "NPM1-ALK-dependent TYK2 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38439", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68668", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004300", "l": "enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201341", "l": "Endocytosis of TRAM (TICAM2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53001", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54405", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75718", "l": "CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71682", "l": "H(+)(out) + L-lysyl-glycine(out) <=> H(+)(in) + L-lysyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23062", "l": "a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28887", "l": "H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49890", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31948", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341294", "l": "Superoxide reduces cytochrome c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851979", "l": "BTNL9 binds immune cell surfaces (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32496", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008479", "l": "tRNA-guanosine(34) queuine transglycosylase activity", "d": ["Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858489", "l": "ppDVL binds DAAM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71861", "l": "glycochenodeoxycholate(in) => glycochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252072", "l": "AZGP1 binds PIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40317", "l": "(2E)-glutaconyl-CoA + H2O2 => glutaryl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47692", "l": "AH2 + neomycin C + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68916", "l": "ATP + butanoate + H(+) + NADPH = AMP + butanal + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694522", "l": "Inner coat assembly and cargo binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25889", "l": "dihydroxyacetone phosphate + iminosuccinate => H(+) + 2 H2O + phosphate + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57214", "l": "N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70896", "l": "N-terminal L-cysteinyl-[protein] + O2 => H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938853", "l": "CDK6 binds RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52597", "l": "lithocholoyl-CoA + NAD(+) => 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030796", "l": "cycloartenol 24-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.201", "l": "\"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5607746", "l": "PKC-delta is activated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51440", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14779", "l": "IMP + NH4(+) => AMP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15563", "l": "8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sterigmatocystin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691621", "l": "C5 binds C5 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35003", "l": "L-fucose(in) = L-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69259", "l": "H2O + progoitrin <=> (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420233", "l": "VIP receptors bind VIP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.227", "l": "\"undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68740", "l": "7-oxocholesterol + H(+) + NADPH = 7alpha-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53978", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13597", "l": "1,4-diguanidinobutane + H2O = agmatine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.20", "l": "\"diguanidinobutanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416698", "l": "SEMA5A binds to PLXNB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27382", "l": "(2R)-2,3-bisphosphoglycerate + H2O => (2R)-2-phosphoglycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65444", "l": "butanoyl-CoA + hexan-1-ol = CoA + hexyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848370", "l": "IL18 binds IL18R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417927", "l": "P2Y2 receptor binds ATP and UTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63522", "l": "3-isopropylcatechol + H2O + NAD(+) => 2-isopropylphenol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004121", "l": "cystathionine beta-lyase activity", "d": ["Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685655", "l": "CTSL bind CTSL inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22468", "l": "GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": [], "t": []}, {"i": "EC:3.5.4.29", "l": "\"GTP cyclohydrolase IIa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75011", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate = 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103047", "l": "methyl beta-D-glucoside 6-phosphate glucohydrolase activity", "d": ["Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209792", "l": "N-acetylation of serotonin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.24", "l": "\"alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43690", "l": "L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate => N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20688", "l": "galactitol + NAD(+) <=> H(+) + keto-D-tagatose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73038", "l": "Co(2+)(out) + H(+)(out) <=> Co(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69471", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68986", "l": "a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010231", "l": "ROBO1 binds FLRT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49602", "l": "AMP + diphosphate + octanedioyl-CoA => ATP + CoA + octanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437230", "l": "L1-FGFR cis-heterodimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035274", "l": "diphenyl phthalate binding", "d": ["Binding to diphenyl phthalate, C(20)H(14)O(4)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689630", "l": "BAP1 binds BAP1-interacting complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866851", "l": "CFTR transits to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13372", "l": "dimethylallyl diphosphate <=> diphosphate + isoprene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.314050959231352", "identifiers": [{"i": "GO:0004713", "l": "protein tyrosine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264615", "l": "Loading of acetylcholine in synaptic vesicles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160010", "l": "protein de-2-hydroxyisobutyrylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]."], "t": []}, {"i": "RHEA:69176", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688137", "l": "RIP2 is K63 polyubiquitinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378975", "l": "Follitropin is a heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051989", "l": "coproporphyrinogen dehydrogenase activity", "d": ["Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27730", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71146", "l": "3-hydroxyhispidin + O2 <=> (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20440", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25058", "l": "(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30962", "l": "9,9'-di-cis-zeta-carotene + a quinone <=> 7,9,9'-tri-cis-neurosporene + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62228", "l": "(E)-ascladiol + A = AH2 + patulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061797", "l": "pH-gated chloride channel activity", "d": ["A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869683", "l": "oxPL binds LBP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209828", "l": "Tryptophan is hydroxylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14261", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone = 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.132", "l": "\"glucarolactone O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14438", "l": "H2O + L-lysine + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15483", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-serine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41394", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218822", "l": "CRK binds BCAR1 and or PXN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3209165", "l": "ID1 sequesters ETS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199093", "l": "CXADR binds to AMICA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47408", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O = (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33422", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56416", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol", "d": [], "t": []}, {"i": "EC:2.4.1.359", "l": "\"glucosylglycerol phosphorylase (configuration-retaining)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.131", "l": "\"carotenoid 1,2-hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65452", "l": "ethanol + hexanoyl-CoA = CoA + ethyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050470", "l": "trimethylamine dehydrogenase activity", "d": ["Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857305", "l": "Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21264", "l": "A + glycolate = AH2 + glyoxylate", "d": [], "t": []}, {"i": "EC:1.1.99.14", "l": "\"glycolate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933292", "l": "LSR trimer binds VLDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74241", "l": "alpha-D-glucose 1-phosphate + D-galactose => phosphate + solabiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791121", "l": "Expression of XBP1(S) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42482", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+) => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691421", "l": "BTK binds BTK inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955844", "l": "RBKS phosphorylates ribose to R5P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004063", "l": "aryldialkylphosphatase activity", "d": ["Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15066", "l": "H2O + N(4)-benzoylagmatine => agmatine + benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655846", "l": "Expression of Mevalonate Kinase (MVK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42134", "l": "nocardicin C => isonocardicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16372", "l": "(R)-lactate + NAD(+) <=> H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156930", "l": "GTP-binding activates eEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390598", "l": "Myosin Binds ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36775", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-L-Fuc-(1->2)-[alpha-D-Gal-(1->3)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.309", "l": "\"UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021478", "l": "WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40443", "l": "6-deoxy-6-sulfo-D-fructose + ATP = 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.184", "l": "\"sulfofructose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449087", "l": "CD4 binds Interleukin-16 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43407", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10715", "l": "L-phenylalanine + O2 <=> 2-phenylacetamide + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685156", "l": "ATR phosphorylates RPA2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14994", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73295", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72089", "l": "2 Na(+)(in) + taurodeoxycholate(in) => 2 Na(+)(out) + taurodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35743", "l": "H(+) + NADPH + O2 + versicolorin B = 2 H2O + NADP(+) + versicolorin A", "d": [], "t": []}, {"i": "EC:1.14.19.n5", "l": "\"versicolorin B desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74346", "l": "O-hexanoyl-(R)-carnitine(in) <=> O-hexanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17818", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110215", "l": "Cleavage of uracil by UNG glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52352", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29808", "l": "ATP + H2O + L-leucine(out) => ADP + H(+) + L-leucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034527", "l": "1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67038", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70426", "l": "an acyl-CoA + H2O <=> a carboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36183", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33496", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate => 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853444", "l": "AURKA phosphorylates PHLDA1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56275", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol <=> 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49062", "l": "a long chain fatty alcohol + FMN + H(+) + H2O => a long-chain alkane + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47695", "l": "AH2 + neomycin C + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43852", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019150", "l": "D-ribulokinase activity", "d": ["Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388900", "l": "Neurotensin receptors can bind neurotensins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43547", "l": "ATP + L-glutamate + tyramine <=> ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44220", "l": "15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008389", "l": "coumarin 7-hydroxylase activity", "d": ["Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031772", "l": "type 2 orexin receptor binding", "d": ["Binding to a type 2 orexin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67125", "l": "a hydroperoxide + L-cysteinyl-[protein] => an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21801", "l": "all-trans-antheraxanthin + L-ascorbate => all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2562526", "l": "PLK1 phosphorylates OPTN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983421", "l": "Journey of cargo through Golgi complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74789", "l": "L-histidyl-L-proline diketopiperazine(out) => L-histidyl-L-proline diketopiperazine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873919", "l": "Phosphorylation of JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29273", "l": "a menaquinone + H2O + trimethylamine => a menaquinol + H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043917", "l": "ribose 1,5-bisphosphate isomerase activity", "d": ["Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614933", "l": "ACEIs bind ACE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626681", "l": "Recruitment of transition zone proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.283939330411002", "identifiers": [{"i": "GO:0004842", "l": "ubiquitin-protein transferase activity", "d": ["Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483219", "l": "PC is exchanged with PI by PITPNB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60113", "l": "(R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005135", "l": "interleukin-3 receptor binding", "d": ["Binding to an interleukin-3 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690152", "l": "USP5 cleaves polyubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382058", "l": "Nck binds to the active PDGF receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804955", "l": "ATM phosphorylates MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700114", "l": "NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389974", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50253", "l": "an acyl-CoA + H(+) + malonyl-CoA => a 3-oxoacyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68137", "l": "acetophenone + H(+) + NADPH => (R)-1-phenylethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24043", "l": "NADPH + 2 oxidized [cytochrome P450] <=> H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3782637", "l": "HDAC8 deacetylates histones (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013435", "l": "RHOD auto-activates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77203", "l": "3'-phosphoadenylyl sulfate + deoxycholate = 3alpha-sulfodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.107", "l": "\"peptidase Do\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351207", "l": "Spermine  => N-acetylated spermine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28442", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578712", "l": "Importin-8 binds AGO2:miRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46475", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38598", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73518", "l": "UDP(out) + UTP(in) <=> UDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72831", "l": "3',3'-cGAMP + H2O = G[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.381333653086259", "identifiers": [{"i": "GO:0016410", "l": "N-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule."], "t": []}, {"i": "REACT:R-HSA-177160", "l": "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27543", "l": "methanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20079", "l": "2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(18) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55903", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 6-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22717", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140295", "l": "pathogen-derived receptor ligand activity", "d": ["The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75858", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65031", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] <=> (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382056", "l": "Crk binds to the active PDGF receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19406", "l": "acetyl-CoA + citrate => (3S)-citryl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61097", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40038", "l": "ATP + L-glutamate + N-acetyl-L-aspartate <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54206", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71783", "l": "MDH2 reduces OA to MAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428273", "l": "SPHK1 phosphorylates sphingoid (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604738", "l": "Active FLT3 dimer binds GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73800", "l": "SAICAR => AICAR + Fumarate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662621", "l": "MT1M binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12695", "l": "3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+) => 3,4-dihydroxypyridine + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0046906", "l": "tetrapyrrole binding", "d": ["Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66358", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36646", "l": "emodin + S-adenosyl-L-methionine <=> H(+) + questin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29321", "l": "ethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74953", "l": "(3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate => (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70655", "l": "H(+)(in) + sarcosine(in) = H(+)(out) + sarcosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51718", "l": "AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166220", "l": "FA anion diffuses laterally to UCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047495", "l": "membrane-oligosaccharide glycerophosphotransferase activity", "d": ["Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73102", "l": "3'-dephospho-CoA(in) + AMP(out) <=> 3'-dephospho-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49532", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = ethylene glycol + H(+) + terephthalate", "d": [], "t": []}, {"i": "EC:3.1.1.102", "l": "\"mono(ethylene terephthalate) hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50979", "l": "prostaglandin D2(out) <=> prostaglandin D2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48964", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784734", "l": "PCSK9 binds LDLR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418850", "l": "Activation of Cdc42 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13498", "l": "5-dehydro-2-deoxy-D-gluconate + ATP => 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877361", "l": "Pyrin binds ASC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4341072", "l": "SUMOylation of RARA with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33649", "l": "(9Z)-hexadecenoyl-CoA + AMP + diphosphate => (9Z)-hexadecenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26069", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O => CoA + H(+) + phosphinomethylmalate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19418", "l": "[phosphate](n) + a dolichyl diphosphate => [phosphate](n+1) + a dolichyl phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46458", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12041", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725315", "l": "ALK-stimulated MYCN gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690395", "l": "SOX9 binds the SOX9 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57190", "l": "glycolate + H(+) + L-arginyl-[protein] => H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858252", "l": "HDLBP binds HDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.222", "l": "\"O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13977", "l": "D-serine = NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.3.1.18", "l": "\"D-serine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707594", "l": "Hemes bind LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49092", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29788", "l": "ATP + glutathione(in) + H2O => ADP + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75233", "l": "H(+) + L-galactonate => H2O + L-galactono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047271", "l": "glycosaminoglycan galactosyltransferase activity", "d": ["Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59154", "l": "AMP + diphosphate + pseudomonoyl-CoA C => ATP + CoA + pseudomonate C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72550", "l": "2-oxoglutarate(in) + taurocholate(out) <=> 2-oxoglutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.146", "l": "\"beta-galactofuranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10191", "l": "acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60369", "l": "urate(out) => urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836435", "l": "p-PKR dimer phosphorylates SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51076", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate = 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22038", "l": "[phosphate](n-1) + D-glucose 6-phosphate + H(+) => [phosphate](n) + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19651", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asp) => ATP + L-aspartate + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45612", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50855", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34254", "l": "1-deoxysphinganine + NADP(+) <=> 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701064", "l": "TRPV1 binds TRPV1 agonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12946", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O => biphenyl-2-ol + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043778", "l": "cobalt-precorrin-8 methylmutase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38571", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052615", "l": "ent-kaurene oxidase activity", "d": ["Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16814", "l": "H2O + L-kynurenine => anthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31673", "l": "dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44681", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45416", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030788", "l": "precorrin-2 C20-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29863", "l": "AMP + GTP = ADP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74150", "l": "(S)-2-benzoylsuccinyl-CoA + CoA <=> benzoyl-CoA + succinyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15868", "l": "AH2 + O2 + tryptamine <=> 4-hydroxytryptamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43677", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77126", "l": "1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,2,3-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43856", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59960", "l": "N(alpha)-acetyl-D-methionine = N(alpha)-acetyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805399", "l": "TAF1 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74430", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54126", "l": "CO2 + excited coelenteramide h monoanion + H(+) => coelenterazine h dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39948", "l": "a 1,3-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53369", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) => H(+) + NADPH + uridine(17) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682563", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54669", "l": "pre-alpha-onocerin => alpha-onocerin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25735", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14979", "l": "3-carboxy-cis,cis-muconate => 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168934", "l": "MAVS interacts with RIPK1 and FADD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247922", "l": "GGCT transforms gGluCys to OPRO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110446", "l": "Phospho-Chico: Activated DINR binds p60:Dp110 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430158", "l": "p-SLP-76 binds VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167192", "l": "Pol II elongation complex moves on the HIV-1 template as transcript elongates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12979", "l": "creatine + phosphate => H2O + N-phosphocreatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173709", "l": "C7 binds C5b:C6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69711", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-glucose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202466", "l": "Interaction of Bcl10 to CARMA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66769", "l": "ATP + coproporphyrin I(in) + H2O => ADP + coproporphyrin I(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805740", "l": "SETD8 methylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191299", "l": "Squalene is oxidized to its epoxide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31346", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51927", "l": "AH2 + menaquinone-9 <=> A + beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53276", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691004", "l": "XPC binds RAD23 and CETN2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22731", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948066", "l": "K63polyUb-IRAK1 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709883", "l": "BIL:ALB scavenges O2.- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69041", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 => 2-nitrobutanedioate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019182", "l": "histamine-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75611", "l": "H2O + plasmodiophorol A = plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30650", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) <=> CDP-1L-myo-inositol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008791", "l": "arginine N-succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11461", "l": "ADP + D-glucose => AMP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042933", "l": "chrysobactin transmembrane transporter activity", "d": ["Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25566", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-4-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72302", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0030558", "l": "RNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390649", "l": "CHRM1,3,5 bind acetylcholine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51935", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite <=> 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034872", "l": "trans-geranyl-CoA isomerase activity", "d": ["Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443926", "l": "Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047625", "l": "adenosylmethionine cyclotransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.2", "l": "\"ribonuclease alpha\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64449", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31438", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47253", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32538", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20863", "l": "(1S,6R)-isopiperitenol + NAD(+) <=> (6R)-isopiperitenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22136", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 = chlorophyllide b + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692437", "l": "ANG binds F-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17269", "l": "macrocin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tylosin", "d": [], "t": []}, {"i": "EC:2.1.1.101", "l": "\"macrocin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69637", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56269", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873850", "l": "STARD5 binds DCA, LCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696183", "l": "AOC3 deaminates BZAM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36676", "l": "octacosanoyl-CoA + sphinganine => CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60146", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52730", "l": "a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097259", "l": "20-aldehyde-leukotriene B4 20-monooxygenase activity", "d": ["Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45184", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55703", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O <=> an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60404", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853319", "l": "FGFR2 fusions dimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30611", "l": "A + all-trans-zeta-carotene = AH2 + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16456", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-formylbenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42964", "l": "uridine(54/55) in tRNA = pseudouridine(54/55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56422", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein] => apo-[D-alanyl-carrier protein] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654651", "l": "Activated FGFR4 binds FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008953", "l": "penicillin amidase activity", "d": ["Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019788", "l": "NEDD8 transferase activity", "d": ["Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59443", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47336", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60002", "l": "formate + 2 H(+) + phosphate => hydroxymethylphosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632677", "l": "PTCH is internalized (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76095", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390909", "l": "HRH2 binds hist (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64733", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.98.1.-", "l": "\"Forming coordination complexes\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450474", "l": "MK2 phosphorylates BRF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029536", "l": "Expression of UGT1A3  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56999", "l": "aldehydo-D-apiose <=> apulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76921", "l": "4-methylcyclohexanone + H(+) + NADPH + NH4(+) => 4-methyl-cyclohexylamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19490", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide => 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19915", "l": "a 3-oxoacyl-[ACP] + H(+) + NADH => a (3R)-hydroxyacyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097697", "l": "tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity", "d": ["Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine."], "t": []}, {"i": "RHEA:54080", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849646", "l": "SPINK5(490-624) binds KLK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73808", "l": "GDP + S-adenosyl-L-methionine => N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60788", "l": "gibberellin A24 + H(+) + O2 = CO2 + gibberellin A9 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22808", "l": "6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2", "d": [], "t": []}, {"i": "EC:1.17.3.3", "l": "\"6-hydroxynicotinate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13797", "l": "a dolichyl phosphate + H2O = di-trans,poly-cis-dolichol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.51", "l": "\"dolichyl-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72159", "l": "glutarate(in) + taurocholate(out) = glutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45690", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112727", "l": "Serine phosphorylation of STATs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42736", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.172", "l": "\"16S rRNA (guanine(1207)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19757", "l": "(3R)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.3.1.20", "l": "\"erythro-3-hydroxy-L-aspartate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24181", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36862", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63586", "l": "2-deoxyecdysone + phosphate => 2-deoxyecdysone 22-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706319", "l": "Active FLT3 binds to SLA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22797", "l": "ATP + D-hamamelose => ADP + D-hamamelose 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28140", "l": "streptothricin F acid => H2O + streptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74800", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77560", "l": "a 1-acyl-sn-glycerol + an acyl-CoA => a 1,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52432", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31661", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33679", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61298", "l": "5-deoxy-D-ribulose 1-phosphate => 5-deoxy-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58804", "l": "5'-pApG-3' + H2O = 5'-ApG-3' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21269", "l": "(R)-canadine + 2 NADP(+) => berberine + H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22627", "l": "(S)-4-hydroxy-2-oxopentanoate <=> acetaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.21", "l": "\"L-carnitine CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8960973", "l": "RLBP1:11cRAL dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35300", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34668", "l": "C30 botryococcene + S-adenosyl-L-methionine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340560", "l": "PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69182", "l": "AMP + thiamine triphosphate => ADP + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47098", "l": "(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate => (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66777", "l": "ATP + H2O + uroporphyrin III(in) => ADP + H(+) + phosphate + uroporphyrin III(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051870", "l": "methotrexate binding", "d": ["Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52088", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871227", "l": "RET binds GFRA4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794346", "l": "NRXNs bind NLGNs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60675", "l": "NAD(+) + nerol <=> H(+) + NADH + neral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0048031", "l": "trisaccharide binding", "d": ["Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17521", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.7", "l": "\"glutaminyl-tRNA synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45229", "l": "a (3E)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210277", "l": "Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59569", "l": "4-aminobutanoate + ATP + L-histidine => ADP + H(+) + L-homocarnosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67267", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805109", "l": "CDK2 phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13288", "l": "ATP + L-cysteine + L-glutamate <=> ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21267", "l": "A + glycolate <=> AH2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22892", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.15", "l": "\"methylenetetrahydrofolate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67452", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.117", "l": "\"(4-O-methyl)-D-glucuronate--lignin esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428749", "l": "Activated TP receptor binds G-proten Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60670", "l": "(1R,3R)-chrysanthemal + H(+) + NADH => (R,R)-chrysanthemol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31575", "l": "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.55", "l": "\"8-oxo-dGTP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47517", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isochenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944230", "l": "Association of procollagen type XVIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840401", "l": "DELE1(143-515) is released into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19144", "l": "all-trans-retinol <=> 11-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674095", "l": "PDGFRs bind type II TKI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451309", "l": "Edited Kainate Receptor binds glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68560", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) = 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.107", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611851", "l": "ADRB2 bind ADR,NAd (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27940", "l": "glycine + glyoxylate => (3R)-3-hydroxy-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419166", "l": "GEFs activate RhoA,B,C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70327", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.428", "l": "\"4-methylthio 2-oxobutanoate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65105", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] => aculene B + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047524", "l": "16-hydroxysteroid epimerase activity", "d": ["Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247960", "l": "Activation of p38 MAPK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52662", "l": "AMP + an L-alpha-aminoacyl-[ACP] + diphosphate => an L-alpha-amino acid + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602472", "l": "Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853956", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090440", "l": "abscisic acid transmembrane transporter activity", "d": ["Enables the transfer of abscisic acid from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53060", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73438", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42082", "l": "all-trans-retinoate + 2 H(+) + NADH => all-trans-retinal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13493", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.152", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60286", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69688", "l": "genistein 7-O-beta-D-glucoside + H2O => beta-D-glucose + genistein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45586", "l": "(2E)-butenoyl-CoA + H2O => 3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627104", "l": "XIAP binds CASP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873927", "l": "Release of STAT1 dimer from active receptor unit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102654", "l": "1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity", "d": ["Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor = 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40703", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31784", "l": "H2O + tuberculosinyl diphosphate => diphosphate + tuberculosinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731072", "l": "SARS-CoV-1 3a tetramer induces potassium efflux (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50637", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69146", "l": "4-guanidinobutanal + H2O2 + NH4(+) => agmatine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858270", "l": "HILPDA binds lipid droplets (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72754", "l": "H2O + ochratoxin A <=> L-phenylalanine + ochratoxin alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006873", "l": "IL21 receptor STAT binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13992", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46533", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58705", "l": "rifampicin hemiaminal => rifampicin ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851018", "l": "BTN2A1 binds DC-SIGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46222", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0045499", "l": "chemorepellent activity", "d": ["Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44282", "l": "4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49120", "l": "H(+) + NADPH + O2 + protoviolaceinate = H2O + NADP(+) + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021050", "l": "HSBP1 oligomer binds ESRs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0070818", "l": "protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64301", "l": "3-phenylpropylamine + pyruvate => 3-phenylpropanal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77024", "l": "D-glutamate + H2O + NAD(+) => 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58846", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-hydroxygeranial + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210430", "l": "Release of L-Glutamate at the synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41693", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46039", "l": "2'-deoxycytidine + UTP <=> dCMP + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46838", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66504", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67629", "l": "ATP + dGMP + L-aspartate => (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373732", "l": "Nephrin trans-homophilic interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31144", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35637", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66478", "l": "gypsogenate 28-beta-D-glucoside + UDP => gypsogenate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420117", "l": "VEGFR2 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51877", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate => desmethylxanthohumol + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74301", "l": "D-isoleucine(in) + D-serine(out) => D-isoleucine(out) + D-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59907", "l": "H2O + NADP(+) + octanal <=> 2 H(+) + NADPH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.221", "l": "\"peptide-O-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-921155", "l": "p-STAT5 dissociates from the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10020", "l": "H2O + L-saccharopine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.10", "l": "\"saccharopine dehydrogenase (NADP(+), L-glutamate-forming)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67460", "l": "(R)-malate + A = AH2 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062067", "l": "chloroplast photosystem I binding", "d": ["Binding to a chloroplast photosystem I."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417127", "l": "Elongation and translocation of the extended telomeric chromosome end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65622", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine => hexadecanoyl-CoA + sphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51290", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685838", "l": "CX3 complex binds D-loop structures (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928610", "l": "PTK2 autophosphorylates at Y397 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684140", "l": "ATM phosphorylates RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218836", "l": "PTK2beta binds alphaVbeta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23404", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.41", "l": "\"phosphoglycerol geranylgeranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23003", "l": "(R)-pantoate + NAD(+) <=> (R)-4-dehydropantoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73200", "l": "maleate(in) + sulfate(out) => maleate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955822", "l": "RUNX1 binds the SOCS4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54518", "l": "(13R)-manoyl oxide + diphosphate => 8-hydroxycopalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.97739419478313", "identifiers": [{"i": "GO:0015295", "l": "solute:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18944", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) <=> a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35099", "l": "fusidate(in) + H(+)(out) = fusidate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9842115", "l": "PSAP(195-273) dimer binds PE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53696", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47584", "l": "a ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317332", "l": "PIP3 recruits AKT to the membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944255", "l": "Association of procollagen type VII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102212", "l": "unsaturated chondroitin disaccharide hydrolase activity", "d": ["Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26298", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27679", "l": "ATP + dCDP => ADP + dCTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341294", "l": "Superoxide reduces cytochrome c (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201669", "l": "Beta-catenin translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670431", "l": "Phosphorylated KIT mutants bind PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32035", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.17", "l": "\"4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10351", "l": "5-oxo-L-proline + ATP + 2 H2O <=> ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218815", "l": "p-6Y-VEGFR2 binds NCK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811454", "l": "MAPKs phosphorylate PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660557", "l": "RAS:GTP binds RAL GDS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56104", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005041", "l": "low-density lipoprotein particle receptor activity", "d": ["Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34003", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 = 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37456", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36714", "l": "ATP + H(+) + H2O + O-ureido-D-serine <=> ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24356", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}, {"i": "EC:5.4.1.1", "l": "\"lysolecithin acylmutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0033699", "l": "DNA 5'-adenosine monophosphate hydrolase activity", "d": ["Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37455", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16462", "l": "ATP + H2O + urate(in) => ADP + H(+) + phosphate + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13242", "l": "ATP + L-fucose => ADP + beta-L-fucose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40474", "l": "(2S)-methylpentadecanoyl-CoA + O2 <=> 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72199", "l": "Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57234", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0043893", "l": "acetate:monoatomic cation symporter activity", "d": ["Enables the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42848", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.331", "l": "\"8-demethyltetracenomycin C L-rhamnosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34802", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417927", "l": "P2Y2 receptor binds ATP and UTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73442", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50157", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416516", "l": "GRK2 sequesters activated Gq (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54881", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106276", "l": "biliberdin reductase NAD+ activity", "d": ["Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443418", "l": "GP1b signaling involves c-Src (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55516", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71931", "l": "fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54660", "l": "an aromatic (S)-hydroxynitrile = an aromatic aldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050171", "l": "phenol beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22052", "l": "A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine", "d": [], "t": []}, {"i": "EC:1.7.99.1", "l": "\"hydroxylamine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086086", "l": "voltage-gated potassium channel activity involved in AV node cell action potential repolarization", "d": ["Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-844447", "l": "NLRP1 senses MDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2534096", "l": "METAP1/2 demethylates GNAT1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112042", "l": "Opioid binds MOR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21751", "l": "(S)-lactaldehyde + NADP(+) <=> H(+) + methylglyoxal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11735", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B <=> H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382054", "l": "PDGF binds to extracellular matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75767", "l": "(9Z)-hexadecenoate + H2O = 10-hydroxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25077", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60466", "l": "2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28669", "l": "(S)-propane-1,2-diol + NAD(+) => H(+) + hydroxyacetone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0055100", "l": "adiponectin binding", "d": ["Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20704", "l": "a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.36", "l": "\"D-amino-acid N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14010", "l": "2 dimethylallyl diphosphate => (R,R)-chrysanthemyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66204", "l": "heptanoyl-CoA + O2 = (2E)-heptenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050266", "l": "rosmarinate synthase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36512", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192061", "l": "CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874849", "l": "CREBRF binds CREB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70178", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate <=> alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030753", "l": "8-hydroxyfuranocoumarin 8-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72103", "l": "Formation of pre-mRNPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985460", "l": "RUNX2 binds RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.755473255981116", "identifiers": [{"i": "GO:0022884", "l": "macromolecule transmembrane transporter activity", "d": ["Enables the transfer of a macromolecule from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23164", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.237", "l": "\"flavonol 7-O-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40631", "l": "H2O + trioctadecanoylglycerol = 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090439", "l": "tetraketide alpha-pyrone synthase activity", "d": ["Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A ."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39773", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693608", "l": "Initial resection of double-strand break ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76661", "l": "butanoate + 2 H(+) + NADPH => butanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39340", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58821", "l": "H(+) + malonate + Na(+)(in) => acetate + CO2 + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433456", "l": "Recruitment of STATs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710353", "l": "GSDMD (1-275) binds cardiolipin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043840", "l": "branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44566", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-decaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.26", "l": "\"[tau protein] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786421", "l": "CHIA hydrolyses chitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203979", "l": "Coat Assembly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39294", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0019912", "l": "cyclin-dependent protein kinase activating kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050570", "l": "4-hydroxythreonine-4-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-(phosphooxy)-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2219524", "l": "PDPK1 binds PIP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74699", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 = (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21446", "l": "H(+) + NADH + trans-2-coumarate => 3-(2-hydroxyphenyl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66490", "l": "quillaic acid 28-beta-D-glucoside + UDP => quillate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72586", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) <=> 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28942", "l": "H(+)(in) + xanthosine(in) <=> H(+)(out) + xanthosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57391", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23875", "l": "(R)-propane-1,2-diol + NAD(+) <=> (R)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0001637", "l": "G protein-coupled chemoattractant receptor activity", "d": ["Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43684", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate = AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17778", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54460", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23649", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650473", "l": "SERPING1 is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879594", "l": "SLCO4C1 mediates the transport of digoxin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19747", "l": "AH2 + L-thyroxine => 3,3',5-triiodo-L-thyronine + A + H(+) + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45444", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30263", "l": "H2O2 + 2 L-ascorbate = 2 H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23721", "l": "ATP + hydrogencarbonate + propanoyl-CoA => (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592398", "l": "Activation of proMMP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26200", "l": "H2O + melamine <=> ammeline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784765", "l": "p-Y705-STAT3 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62404", "l": "(R)-2-hydroxyhexadecanoate + O2 = CO2 + H2O + pentadecanoate", "d": [], "t": []}, {"i": "EC:1.14.18.12", "l": "\"2-hydroxy fatty acid dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750666", "l": "ALB binds ST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.119", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31426", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11673", "l": "chorismate + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050004", "l": "isoflavone 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48743", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine <=> [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050644", "l": "cis-p-coumarate glucosyltransferase activity", "d": ["Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090613", "l": "5'-deoxyadenosine deaminase activity", "d": ["Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35763", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33982", "l": "DIBOA beta-D-glucoside + H2O <=> D-glucose + DIBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696131", "l": "AOC1 deaminates Hist (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21717", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48338", "l": "a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466832", "l": "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201443", "l": "Type II receptor phosphorylates type I receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389969", "l": "Beta-tubulin:GTP + Cofactor D ->  Beta-tubulin:GTP: Cofactor D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19246", "l": "N-phenylhydroxylamine => 2-aminophenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16353", "l": "2-oxoglutarate + taurine = L-glutamate + sulfoacetaldehyde", "d": [], "t": []}, {"i": "EC:2.6.1.55", "l": "\"taurine--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45288", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77559", "l": "a 1-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35123", "l": "H(+)(out) + L-alanyl-D-glutamate(out) = H(+)(in) + L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034560", "l": "bisphenol A hydroxylase A activity", "d": ["Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62258", "l": "Cd(2+)(in) + 2 hydrogencarbonate(in) => Cd(2+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57962", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfide + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68410", "l": "2-oxosuberate + CO2 + NADH => (2R,3S)-iso(homo)3citrate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72583", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) = 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36817", "l": "dTDP-alpha-D-fucofuranose => dTDP-alpha-D-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10812", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.71", "l": "\"succinylglutamate-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74083", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol = diphosphate + menaquinol-4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76912", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NAD(+) => 3-methylcyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39618", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA <=> (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68380", "l": "3-hydroxypyruvate + L-asparagine = 2-oxosuccinamate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205231", "l": "Dimerization of KIT upon SCF binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73623", "l": "CTP(out) + GDP(in) = CTP(in) + GDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74779", "l": "laricitrin + S-adenosyl-L-methionine = 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419462", "l": "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35674", "l": "(S)-5'-oxoaverantin + H(+) <=> (1'S,5'S)-averufin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71654", "l": "a thymidine in DNA + NAD(+) <=> an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0016922", "l": "nuclear receptor binding", "d": ["Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43480", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9671145", "l": "DKC1 binds SHQ1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13265", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": [], "t": []}, {"i": "EC:2.1.4.2", "l": "\"scyllo-inosamine-4-phosphate amidinotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602885", "l": "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661217", "l": "MT1A binds zinc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45343", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O <=> (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71209", "l": "iodide(in) + 2 Na(+)(in) => iodide(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444647", "l": "C3a receptor binds anaphylatoxin C3a (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.23", "l": "\"acylglycerol lipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.-.-", "l": "\"Acyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10306", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP] => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n2", "l": "\"blood group B linear chain alpha-1,3-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38473", "l": "3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine => L-histidine + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50027", "l": "dodecanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.102", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21700", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.77", "l": "\"acireductone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23065", "l": "an alkanesulfonate + FMNH2 + O2 => an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73836", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.755473255981116", "identifiers": [{"i": "GO:0010333", "l": "terpene synthase activity", "d": ["Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75181", "l": "(R)-axinyssene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209891", "l": "Dopamine is oxidised to noradrenaline (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71564", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA => 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21197", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine => L-methionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4332359", "l": "Active calmodulin binds CAMK2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296301", "l": "CCRL2 binds CCL19 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39564", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42544", "l": "uridine(32) in tRNA = pseudouridine(32) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.28", "l": "\"tRNA pseudouridine(32) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51810", "l": "(9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043423", "l": "3-phosphoinositide-dependent protein kinase binding", "d": ["Binding to a 3-phosphoinositide-dependent protein kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48473", "l": "a ganglioside GT1a + H2O => a ganglioside GD1a + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24028", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.1", "l": "\"gamma-butyrobetaine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56784", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": [], "t": []}, {"i": "EC:3.4.19.9", "l": "\"folate gamma-glutamyl hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029468", "l": "Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56294", "l": "4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27720", "l": "inosine + phosphate => H2O + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28107", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-D-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.65", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68960", "l": "DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29675", "l": "glycerol(in) = glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45438", "l": "H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate => H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64640", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose = lactose + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.1", "l": "\"pepsin A\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13002", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53356", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) = H(+) + NADPH + uridine(20b) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29155", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) = 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71551", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31248", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol => prop-2-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71881", "l": "H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide => 2'-deoxyguanosine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36168", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141367", "l": "Myristoylation of tBID by NMT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809354", "l": "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17274", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) => 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371527", "l": "HSF1 trimer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781814", "l": "USP19 deubiquitinates RNF123 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73932", "l": "Resynthesis of excised residue by POLB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58888", "l": "4-aminobenzoate + AH2 + 2 O2 = 4-nitrobenzoate + A + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.99.68", "l": "\"4-aminobenzoate N-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696271", "l": "RND1 binds effectors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19332", "l": "nuatigenin + UDP-alpha-D-glucose <=> H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848776", "l": "PTK6 phosphorylates DOK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67417", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58195", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin <=> dihydrobisanhydrobacterioruberin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38296", "l": "(R)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76073", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out) => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209289", "l": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43592", "l": "all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45240", "l": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": [], "t": []}, {"i": "EC:5.3.3.21", "l": "\"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749215", "l": "MCM8 binds CDC6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34198", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 <=> 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21354", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+) => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23100", "l": "ATP + dAMP = ADP + dADP", "d": [], "t": []}, {"i": "EC:2.7.4.11", "l": "\"(deoxy)adenylate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938108", "l": "SERPINB13 binds cathepsin L (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672969", "l": "Phosphorylation of RAF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31345", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693356", "l": "CEMIP hydrolyses HA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168923", "l": "Collagen type XVIII endostatin release (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443831", "l": "14-3-3-zeta binds Raf1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47169", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52778", "l": "camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27856", "l": "3-geranyl-4-hydroxybenzoate + diphosphate => (2E)-geranyl diphosphate + 4-hydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70481", "l": "TPI1 isomerizes GA3P to DHAP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77068", "l": "Activation of GT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67887", "l": "3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264615", "l": "Loading of acetylcholine in synaptic vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21293", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997237", "l": "SH2B proteins bind JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49042", "l": "(-)-yatein + H(+) + S-adenosyl-L-homocysteine => (-)-5'-demethylyatein + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.760981911179996", "identifiers": [{"i": "GO:0097747", "l": "RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33959", "l": "2-oxoglutarate + neomycin C = 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.95", "l": "\"neomycin C transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.54", "l": "\"ketosteroid monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73800", "l": "SAICAR => AICAR + Fumarate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72746", "l": "leukotriene C4(out) <=> leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63328", "l": "2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42672", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.50", "l": "\"gamma-glutamyl hercynylcysteine S-oxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49907", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14110", "l": "L-proline + NADP(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33213", "l": "2-demethylmenaquinol-7 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987043", "l": "IL22RA1 binds JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39761", "l": "19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400046", "l": "L-type Calcium Channels close in pancreatic beta cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56202", "l": "H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004376", "l": "glycolipid mannosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769397", "l": "SOST binds LRP5/6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197690", "l": "Detachment of WASP/WAVE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21653", "l": "2-chlorobenzoate + H(+) + NADH + O2 => catechol + chloride + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.5", "l": "\"ribonuclease D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19334", "l": "H(+) + oxalyl-CoA => CO2 + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52287", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419049", "l": "ROCK activation by RHO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983194", "l": "Kinesin-1 is a heterotetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017095", "l": "heparan sulfate 6-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate."], "t": []}, {"i": "REACT:R-HSA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427337", "l": "MBD2 binds methylcytosine in chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67677", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40201", "l": "16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67002", "l": "3 CO2 + 4 CoA + phlorisobutanophenone => 2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66147", "l": "5-methoxytryptamine + acetyl-CoA <=> CoA + H(+) + melatonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786854", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77459", "l": "3-formylthiophene + hydrogen cyanide = (2S)-2-hydroxy-2-(thiophen-3-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31340", "l": "acetate + ATP + holo-[ACP] => acetyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709360", "l": "H2O2 reduces MetHb (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163320", "l": "Association of mTERF with the termination sequence (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306876", "l": "NLRP3 activation by small molecules (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61818", "l": "16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP => 16,17-didehydropregnenolone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10675", "l": "cyclobutadithymidine in DNA <=> a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47274", "l": "bisanhydrobacterioruberin + H2O => monoanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167136", "l": "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784734", "l": "PCSK9 binds LDLR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801776", "l": "REG3A binds bacterial phospholipids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975118", "l": "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71290", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) <=> chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17907", "l": "3-hydroxypyruvate + H(+) + NADH => (R)-glycerate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061714", "l": "folic acid receptor activity", "d": ["Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34039", "l": "2-oxoglutarate + neamine = 6'-oxoparomamine + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.93", "l": "\"neamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48150", "l": "ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)/18:0) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434836", "l": "Syk/Lck phosphorylate LAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9817575", "l": "ERO1B oxidizes P4HB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102715", "l": "gibberellin A17,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 = gibberellin A28 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60299", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60734", "l": "2 H(+) + NADPH + perillate => H2O + NADP(+) + perillyl aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52789", "l": "chlorophyll a + 2 H(+) => Mg(2+) + pheophytin a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56929", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69895", "l": "cytidine(out) + Na(+)(out) = cytidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443779", "l": "Linkage of L1 with treadmilling F-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71415", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) = 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618394", "l": "ARL4C gene transcription regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033958", "l": "DNA-deoxyinosine glycosylase activity", "d": ["Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.299594003468286", "identifiers": [{"i": "GO:0015081", "l": "sodium ion transmembrane transporter activity", "d": ["Enables the transfer of sodium ions (Na+) from one side of a membrane to the other."], "t": []}, {"i": "RHEA:34963", "l": "Na(+)(in) = Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.496617203483822", "identifiers": [{"i": "GO:0015154", "l": "disaccharide transmembrane transporter activity", "d": ["Enables the transfer of disaccharide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198756", "l": "ERK1/2 phosphorylates MSK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.17", "l": "\"inulin fructotransferase (DFA-I-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51852", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0032546", "l": "deoxyribonucleoside binding", "d": ["Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66823", "l": "ATP + H2O + Mn(2+)(in) <=> ADP + H(+) + Mn(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69369", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) => 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15162", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42109", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641229", "l": "TLE oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420980", "l": "Activation of Ca permeable AMPA receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62428", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA = 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632887", "l": "TP53 binds the RRM2B gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173725", "l": "C9 binds C5b:C6:C7:C8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55138", "l": "D-alanyl-5'-AMP + diphosphate => ATP + D-alanine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33401", "l": "L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483077", "l": "PE transports from the mitochondrial membrane to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49403", "l": "H2O + validoxylamine A 7'-phosphate <=> phosphate + validoxylamine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22238", "l": "2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017491", "l": "RHOJ GEFs activate RHOJ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54349", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801195", "l": "STEAP3 binds BNIP3L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67882", "l": "adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10255", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine <=> L-cysteine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614461", "l": "Tetramerization of procollagen VI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75357", "l": "3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate => H2O + L-mimosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626699", "l": "MARK4 binds ODF2 in the centriole (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43154", "l": "H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine => adenosine(58) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810376", "l": "ING2 binds PI5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013023", "l": "RHOB GEFs activate RHOB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56005", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863973", "l": "Fusion of ERC and phagosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52023", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> A + H2O + resolvin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49271", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088162", "l": "FOXM1 binds CDC25A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36333", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate => ATP + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71303", "l": "RPE dimers isomerise RU5P to XY5P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67966", "l": "4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-L-phenylalanine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39691", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH = (11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13668", "l": "GTP <=> 3',5'-cyclic GMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32115", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 = CO2 + succinate + TRIBOA beta-D-glucoside", "d": [], "t": []}, {"i": "EC:1.14.11.59", "l": "\"2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43723", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine <=> juvenile hormone III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47437", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27430", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-873917", "l": "Translocation of STAT1 dimer to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635842", "l": "ULK3 phosphorylates GLI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18926", "l": "L-gulono-1,4-lactone + NADP(+) => D-glucurono-3,6-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72471", "l": "citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo-isocitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015489", "l": "putrescine transmembrane transporter activity", "d": ["Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68572", "l": "L-tyrosine(in) = L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22130", "l": "(1S,4S)-camphor + H(+) + NADH => (1S,2R,4S)-borneol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57088", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14383", "l": "4-guanidinobutanoate + 2 H(+) + NADH => 4-guanidinobutanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046408", "l": "chlorophyll synthetase activity", "d": ["Catalysis of the reaction: chlorophyllide a + 2 H+ + phytyl diphosphate = chlorophyll a + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37523", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75564", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] => cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69468", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}, {"i": "EC:2.6.1.122", "l": "\"UDP-N-acetyl-3-dehydro-alpha-D-glucosamine 3-aminotranferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418856", "l": "Activation of Rac1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45056", "l": "deoxynogalonate + O2 = H(+) + H2O + nogalonate", "d": [], "t": []}, {"i": "EC:1.13.12.22", "l": "\"deoxynogalonate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33318", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65143", "l": "AH2 + O2 + protoaustinoid A <=> A + berkeleyone A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193653", "l": "NGF homodimer binds to p75NTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025890", "l": "Calcineurin binds NFATC1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673296", "l": "WNT5:FZD7 binds p-DVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14248", "l": "ATP + H2O <=> AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870558", "l": "CDK5:p25 phosphorylates FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443831", "l": "14-3-3-zeta binds Raf1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17888", "l": "acetaldehyde <=> acetylene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66128", "l": "2-oxobutanoate + L-phenylalanine = (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139893", "l": "Granzyme-B activates BID by cleavage (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73123", "l": "isorhamnetin + S-adenosyl-L-methionine = H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008473", "l": "ornithine cyclodeaminase activity", "d": ["Catalysis of the reaction: L-ornithine = L-proline + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351913", "l": "Caspase-mediated cleavage of TJP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63505", "l": "daunorubicin + H(+) + NADPH => 13-dihydrodaunorubicin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352961", "l": "dihydroxyacetone phosphate + glyceraldehyde 3-phosphate <=> fructose 1,6-bisphosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60668", "l": "(R,R)-chrysanthemol + NAD(+) = (1R,3R)-chrysanthemal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33068", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O => (4R)-hydroxysphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36198", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141002", "l": "histone H4K16 propionyltransferase activity", "d": ["Catalysis of the reaction: histone H4 L-lysine (position 16) + propionyl-CoA = CoA + H+ + histone H3 N6-propionyl-L-lysyl (position 16)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57880", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44300", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA = 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.82", "l": "\"putrescine--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.327", "l": "\"aclacinomycin-T 2-deoxy-L-fucose transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22844", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658438", "l": "SPRED dimer binds NF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938338", "l": "NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22969", "l": "butanal + CoA + NAD(+) => butanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004962", "l": "endothelin receptor activity", "d": ["Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944215", "l": "Association of procollagen type XX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43424", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098600", "l": "selenomethionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid."], "t": []}, {"i": "REACT:R-HSA-2408537", "l": "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40602", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417820", "l": "P2Y9 receptor can bind to LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19584", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine <=> discadenine + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004042", "l": "acetyl-CoA:L-glutamate N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56411", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50588", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74165", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37921", "l": "(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74990", "l": "erythrostominone(in) <=> erythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14832", "l": "hydrogen sulfide + O-acetyl-L-serine <=> acetate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25275", "l": "ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate => ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73819", "l": "choline(in) + 2 H(+)(out) = choline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796626", "l": "MIB2 ubiquitinates CFLAR  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.253", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59244", "l": "3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34417", "l": "(1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1R,4R)-bornane-2,5-dione + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13606", "l": "2 L-ascorbate + O2 => 2 H2O + 2 L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098744", "l": "1-phosphatidylinositol 4-kinase activator activity", "d": ["Binds to and increases the activity of 1-phosphatidylinositol 4-kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28934", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545196", "l": "FN1 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0061596", "l": "3-sulfolactaldehyde reductase activity", "d": ["Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12412", "l": "(2R)-3-phosphoglycerate + H2O = (R)-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.38", "l": "\"3-phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63081", "l": "AH2 + ATP + ilicicolinate B => A + AMP + diphosphate + ilicicolin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53589", "l": "NAD(+) + resolvin D2 => 16-oxoresolvin D2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67700", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65134", "l": "CO2 + H2O + preaustinoid A2 + succinate => 2-oxoglutarate + O2 + preaustinoid A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23290", "l": "acetyl-CoA + H(+) + NADH => acetaldehyde + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70015", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone = 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433451", "l": "JAK2 binds to p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749977", "l": "UGT1A6 glucuronates ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53553", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872463", "l": "SLC9C1 exchanges Na+ for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35320", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA => 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944255", "l": "Association of procollagen type VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37482", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70900", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58007", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39592", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173680", "l": "Activation of C5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36197", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71110", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) <=> L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111238", "l": "Formation of ADAR2  homodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42651", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O <=> (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35604", "l": "beta-D-fructose 1-phosphate + H2O => D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448678", "l": "CTSG cleaves CASP1(1-404) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209235", "l": "Phosphorylated BSK kinase transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41652", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose = 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48477", "l": "a ganglioside GT1a (d18:1(4E)) + H2O => a ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68042", "l": "(3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+) => (R)-lanthionine ketimine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51427", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781905", "l": "ZRANB1 binds APC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46625", "l": "a D-5-monosubstituted hydantoin => a L-5-monosubstituted hydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45404", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374662", "l": "Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0038132", "l": "neuregulin binding", "d": ["Binding to a neuregulin, a member of the EGF family of growth factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19678", "l": "9'-cis-neoxanthin + O2 => (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30919", "l": "A + rhodopin = (3E)-3,4-didehydrorhodopin + AH2", "d": [], "t": []}, {"i": "EC:1.3.99.27", "l": "\"1-hydroxycarotenoid 3,4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65184", "l": "2-oxoglutarate + O2 + preaustinoid A1 = berkeleyone B + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71574", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) <=> 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102159", "l": "baicalein 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein = H+ + UDP + baicalin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080073", "l": "spermidine:coumaroyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75295", "l": "chloride(in) + sulfate(out) = chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65871", "l": "Delta(1)-dihydrotestosterone + H2O <=> 1,17beta-dihydroxyandrostan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65285", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65842", "l": "ATP(in) + Mg(2+)(in) + phosphate(out) => ATP(out) + Mg(2+)(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102803", "l": "thebane O-demethylase activity", "d": ["Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 = oripavine + formaldehyde + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046428", "l": "1,4-dihydroxy-2-naphthoate octaprenyltransferase activity", "d": ["Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51696", "l": "desmethylxanthohumol + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49741", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868236", "l": "BAR domain proteins recruit dynamin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031434", "l": "mitogen-activated protein kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24352", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.279", "l": "\"(R)-3-hydroxyacid-ester dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0032934", "l": "sterol binding", "d": ["Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55472", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.68", "l": "\"syn-pimaradiene 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60477", "l": "2 ATP + GTP => 3',3',3'-cAAG + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47814", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35460", "l": "cholesterol + NAD(+) => cholest-5-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72761", "l": "anthocyanin A8 + CoA => anthocyanin A6 + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27801", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-octaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31916", "l": "ATP + D-maltose => ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168324", "l": "Conformation change in hemagglutinin freeing the fusion peptide of HA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50399", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA <=> 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17389", "l": "D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.250", "l": "\"D-arabinitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218815", "l": "p-6Y-VEGFR2 binds NCK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73114", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether <=> ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046569", "l": "glyoxal oxidase activity", "d": ["Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42410", "l": "(2R)-2,3-bisphosphoglycerate + ADP + H(+) => (2R)-2-phosphoglycerate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033192", "l": "calmodulin-dependent protein phosphatase activity", "d": ["Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57054", "l": "CO2 + L-erythrulose => 3-oxoisoapionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55586", "l": "an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70749", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050112", "l": "inositol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805638", "l": "KAT6A acetylates TP53 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.59", "l": "\"caspase-6\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622630", "l": "FOXO3,FOXO4,(FOXO1) bind BCL6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41555", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + ophiobolin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68126", "l": "a triacylglycerol + holo-[ACP] => a 1,2-diacylglycerol + a fatty acyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.44", "l": "\"alanine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005520", "l": "insulin-like growth factor binding", "d": ["Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30930", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56491", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31733", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O => 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57125", "l": "2-oxoglutaramate => 2-hydroxy-5-oxoproline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2471842", "l": "Collagen type XXV ectomain shedding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16561", "l": "H2O + squalene = hopan-22-ol", "d": [], "t": []}, {"i": "EC:4.2.1.129", "l": "\"squalene--hopanol cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799332", "l": "ATR phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46901", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21096", "l": "3-dehydroquinate = 3-dehydroshikimate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.10", "l": "\"3-dehydroquinate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9679044", "l": "FKBP1A binds sirolimus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222093", "l": "BRD7 binds TP53 and EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350436", "l": "DGO binds to DSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34133", "l": "cannabinerolate + diphosphate => neryl diphosphate + olivetolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374701", "l": "Phosphorylation of DCC by Fyn (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12140", "l": "a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016707", "l": "gibberellin 3-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25377", "l": "a 2-methyl-branched fatty aldehyde + formyl-CoA => a 2-hydroxy-3-methyl fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69395", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071858", "l": "corazonin receptor binding", "d": ["Binding to a corazonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75676", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624800", "l": "CDK1 phosphorylates LBR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111264", "l": "Addition of nucleotides between position +11 and +30 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50957", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14977", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate", "d": [], "t": []}, {"i": "EC:5.5.1.5", "l": "\"carboxy-cis,cis-muconate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77082", "l": "2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + N,N-dimethyl-cadaverine <=> H(+) + pre-flavunoidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086410", "l": "CDK1 phosphorylates BORA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748991", "l": "XDH oxidises 6MP to 6TU (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18101", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.66", "l": "\"cis-dihydroethylcatechol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618331", "l": "HDAC6 deacetylates microtubules (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618107", "l": "ATP binding to HSP90 triggers conformation change (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250884", "l": "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39889", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.155", "l": "\"xyloglucan-specific endo-processive beta-1,4-glucanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54563", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP <=> a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53721", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57165", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 => (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16262", "l": "L-lysyl-[protein] + succinyl-CoA => CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58688", "l": "NADH + O2 + rifamycin SV = H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72964", "l": "acetoacetate(out) + 2 Na(+)(out) => acetoacetate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655142", "l": "RCHY1 binds POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64408", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.117", "l": "\"hydroxycinnamoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373724", "l": "Nephrin binds NCK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008191", "l": "metalloendopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870461", "l": "RABGGTA and RABGGTB bind (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165195", "l": "GTP loading by Rheb (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043804", "l": "imidazolone hydrolase activity", "d": ["Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one."], "t": []}, {"i": "RHEA:24935", "l": "H2O + imidazol-4-one = N-formimidoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46588", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34346", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38284", "l": "itaconate + succinyl-CoA => itaconyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757954", "l": "N4BP1 binds IKBKG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399952", "l": "Phosphorylation of LIMK-1 by PAK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56821", "l": "AH2 + cyclooctat-9-en-7-ol + O2 => A + cyclooctat-9-ene-5,7-diol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.1", "l": "\"NAD(P)H oxidase (H2O2-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69470", "l": "L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030268", "l": "methylenetetrahydromethanopterin dehydrogenase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H+ = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159227", "l": "HIV Virion Budding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17223", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O => dTDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9621179", "l": "Cinaciguat binds sGC:NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712084", "l": "PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373129", "l": "fumarate + FADH2 <=> succinate + FAD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43787", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67835", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65743", "l": "2-oxoglutarate + nonyl sufate + O2 <=> CO2 + H(+) + nonanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001071", "l": "maltoheptaose binding", "d": ["Binding to maltoheptaose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15954", "l": "agmatine + ATP => ADP + 2 H(+) + N(4)-phosphoagmatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47412", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015310", "l": "benomyl:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17275", "l": "4-hydroxyphenylacetate + 2 H(+) + NADH => (4-hydroxyphenyl)acetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707856", "l": "PGRMC2:Hemes dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67425", "l": "a glycerophospholipid + H2O => a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110164", "l": "SMUG1 glycosylase mediated recognition and binding of uracil in DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45660", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213241", "l": "Formation of nonameric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41177", "l": "methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine => Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209924", "l": "Dopa is decarboxylated to dopamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419214", "l": "5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49960", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 = 5,10-dihydrophenazine + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42920", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.193", "l": "\"16S rRNA (uracil(1498)-N(3))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-708349", "l": "Activated NOD2 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434989", "l": "SEMA7A binds to PLXNC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928656", "l": "gamma-secretase cleaves EPHB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867613", "l": "PICALM binds R-SNAREs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651789", "l": "LIG1 bound to POLB ligates SSB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46071", "l": "(3E)-nonenoyl-CoA <=> (2E)-nonenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607734", "l": "PKC-delta translocates to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61754", "l": "H(+) + rebaudioside B + UDP => steviolbioside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46140", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47547", "l": "trans-4-hydroxy-L-proline betaine <=> cis-4-hydroxy-D-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416358", "l": "G alpha (q) inhibits PI3K alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57400", "l": "3-O-acetylpapaveroxine + H2O = acetate + H(+) + narcotine hemiacetal", "d": [], "t": []}, {"i": "EC:3.1.1.105", "l": "\"3-O-acetylpapaveroxine carboxylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75823", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250280", "l": "ROS oxidize thioredoxin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019772", "l": "low-affinity IgG receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75850", "l": "Addition of the third nucleotide on the nascent transcript (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050643", "l": "10-deacetylbaccatin III 10-O-acetyltransferase activity", "d": ["Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71244", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) => chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004686", "l": "elongation factor-2 kinase activity", "d": ["Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73463", "l": "carcinine + H2O = beta-alanine + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8857686", "l": "FITM1, FITM2 bind TAGs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12192", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.166", "l": "\"(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948066", "l": "K63polyUb-IRAK1 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39929", "l": "1-O-alkyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22230", "l": "diphosphate + NAD(+) + squalene => H(+) + NADH + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51644", "l": "cholesterol + H(+) + NADH + O2 = 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69815", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53961", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112429", "l": "Formation of FACT complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139905", "l": "Translocation of activated BAD protein to mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21397", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) => CO2 + Na(+)(out) + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29195", "l": "(S)-dihydroorotate + a menaquinone = a menaquinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443774", "l": "Trans-homodimerization of Neurofascin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.47", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33998", "l": "gamma-L-glutamyl-butirosin B <=> 5-oxo-L-proline + butirosin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0052736", "l": "beta-glucanase activity", "d": ["Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20914", "l": "diphosphate + taxa-4,11-diene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44231", "l": "9-decenoate + ATP + CoA <=> 9-decenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13612", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625375", "l": "FOXO3,FOXO4 bind STK11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44471", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41346", "l": "(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40875", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080095", "l": "phosphatidylethanolamine-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33674", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O <=> 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193702", "l": "Part of the ICD migrates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865275", "l": "PDGF-BB clevage by Furin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23087", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57129", "l": "H2O + 2 oxidized [azurin] + tyramine => (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59035", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825422", "l": "P protein oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60184", "l": "ATP + D-glucose(out) + H2O = ADP + D-glucose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21442", "l": "a long-chain alkane + formate + H2O + 2 NADP(+) => a long-chain fatty aldehyde + H(+) + 2 NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65898", "l": "glycine + H2O + kynurenate => glyoxylate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009022", "l": "tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448963", "l": "Interaction of MyoD:E protein with MEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49014", "l": "aurachin C epoxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24438", "l": "dihydromethanophenazine => H2 + methanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62855", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54507", "l": "all-trans-hexaprenyl diphosphate <=> beta-hexaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76367", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46199", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940554", "l": "MMP2 cleaves OPTC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042781", "l": "3'-tRNA processing endoribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13636", "l": "ATP + L-glutamate + putrescine <=> ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700154", "l": "Active ALK binds SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15054", "l": "(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018758", "l": "RHOH binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227694", "l": "dsRNA binds to MDA5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033972", "l": "proclavaminate amidinohydrolase activity", "d": ["Catalysis of the reaction: amidinoproclavaminate + H2O = proclavaminate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47355", "l": "a hexanoate ester + H2O <=> an aliphatic alcohol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827872", "l": "Expression of PRDM1 in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64247", "l": "a fatty acyl-CoA + glycine <=> an N-(fatty acyl)-glycine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19971", "l": "H(+) + H2O + nitrite => hydroxylamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.130943529370171", "identifiers": [{"i": "GO:0016755", "l": "aminoacyltransferase activity", "d": ["Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.3.2.-", "l": "\"Aminoacyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050244", "l": "pyruvate oxidase (CoA-acetylating) activity", "d": ["Catalysis of the reaction: CoA + H+ + O2 + pyruvate = acetyl-CoA + CO2 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802914", "l": "RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42291", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791235", "l": "GADD45A binds AURKA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140728", "l": "GC-box binding", "d": ["Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72656", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 => 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352268", "l": "Cleavage of Satb1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865182", "l": "OTUD7A hydrolyses K11diUb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389348", "l": "Activation of Rac1 by pVav1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161662", "l": "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018639", "l": "xylene monooxygenase activity", "d": ["Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1362416", "l": "Frataxin binds iron (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322431", "l": "XIAP binds TLE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63096", "l": "ilicicolin A epoxide = ilicicolin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851988", "l": "BTN2A2 binds T cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316352", "l": "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17809", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.11", "l": "\"magnesium protoporphyrin IX methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683774", "l": "p-T68-CHEK2 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956659", "l": "ABL1 phosphorylates YAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022462", "l": "MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814094", "l": "ARL1:GTP binds ARFIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73658", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809010", "l": "COPI vesicle uncoating (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445072", "l": "Interaction of PAK1 with Rac1-GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52852", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.14.14.46", "l": "\"pimeloyl-[acyl-carrier protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008707", "l": "4-phytase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629483", "l": "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58260", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] = ADP-D-ribose + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44397", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168888", "l": "Alpha1-Microglobulin binds heme (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61382", "l": "2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate => 2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730841", "l": "Phosphorylation and activation of VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380224", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43190", "l": "H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2634) in 25S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29141", "l": "2 H(+)(out) + H2O + menaquinone-8 + nitrite => 2 H(+)(in) + menaquinol-8 + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862184", "l": "USP48 cleaves polyubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32306", "l": "(2R)-homocitrate <=> (2R,3S)-homoisocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831006", "l": "Expression of SIX2 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610726", "l": "The IFT-A complex recruits TULP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57072", "l": "3-oxoisoapionate 4-phosphate + H(+) = CO2 + L-erythrulose 1-phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.121", "l": "\"3-oxoisoapionate-4-phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53184", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19328", "l": "H(+) + NADH + O2 + quinolin-4-ol <=> H2O + NAD(+) + quinoline-3,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102433", "l": "phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity", "d": ["Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate = L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20031", "l": "H(+) + NADPH + vellosimine => 10-deoxysarpagine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29190", "l": "succinate + ubiquinone-8 <=> fumarate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13607", "l": "2 H2O + 2 L-dehydroascorbate => 2 L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.7", "l": "\"D-glutamate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106319", "l": "(R)-limonene 1,2-monooxygenase NADH activity", "d": ["Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48355", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620103", "l": "ALDH2 transforms GTN to NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031759", "l": "Edg-6 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-6 sphingosine 1-phosphate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050322", "l": "taurine-2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322427", "l": "Beta-catenin recruits CBP/p300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16007", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => galactarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52321", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645535", "l": "ALPK1 phosphorylates TIFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807565", "l": "GNLY is transferred to the phagosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13714", "l": "a ubiquinone + succinate => a ubiquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848077", "l": "PTK6 phosphorylates STAP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71399", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010331", "l": "gibberellin binding", "d": ["Binding to a gibberellin, a plant hormone that regulates aspects of plant growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22404", "l": "beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62247", "l": "a cytidine(6-4)thymidine in DNA <=> a cytidine-thymine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0016634", "l": "oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.3.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75331", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) = chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69295", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> goitrin + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433961", "l": "Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40426", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14517", "l": "(E)-feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873918", "l": "Transphosphorylation of JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15036", "l": "O2 + pyridoxine <=> H2O2 + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853745", "l": "RET binds GFRA1,GFRA3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032770", "l": "Translocation of YAP1 to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800250", "l": "TP53 stimulates BCL6 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120092", "l": "crotonyl-CoA hydratase activity", "d": ["Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine."], "t": []}, {"i": "RHEA:45584", "l": "3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45911", "l": "chloroorienticin B + dTDP-beta-L-vancosamine <=> chloroeremomycin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099521", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential", "d": ["Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3244643", "l": "STING binds cyclic GMP-AMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73510", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine <=> 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75826", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69001", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine => 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211968", "l": "CYP2W1 oxidises INDOL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76456", "l": "O-atom dealkylation of dextromethorphan (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18401", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.37", "l": "\"4-hydroxyphenylacetaldehyde oxime monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27798", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.90", "l": "\"all-trans-octaprenyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34737", "l": "an N-acylsphinganine + CoA + H(+) => a fatty acyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952226", "l": "RUNX3 binds the BCL2L11 (BIM) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25935", "l": "4-methylquinoline + A + H2O <=> 4-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32088", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58699", "l": "NADPH + O2 + rifampicin <=> H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008650", "l": "rRNA (uridine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine."], "t": []}, {"i": "REACT:R-HSA-6793127", "l": "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481010", "l": "Surface deployment of platelet dense granule membrane components (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53412", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60863", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37075", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.8.4.5", "l": "\"tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635446", "l": "Rv3654c binds SFPQ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2399913", "l": "atRAL binds to RBP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66449", "l": "(E)-pent-2-en-1-ol + NADP(+) => (E)-2-pentenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12676", "l": "an aliphatic amide <=> a nitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791349", "l": "Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047115", "l": "trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76815", "l": "D-alanine + H2O + NAD(+) = H(+) + NADH + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32076", "l": "geranylgeranyl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59753", "l": "L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63947", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine <=> an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696465", "l": "USP45 deubiquitinates ERCC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65768", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.38", "l": "\"N,N-dimethyl phenylurea N-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43355", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37976", "l": "H(+) + homogentisate + phytyl diphosphate => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46752", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44022", "l": "2 H(+) + NADH + octadecanoate => H2O + NAD(+) + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41226", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56161", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate => an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52121", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64133", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67828", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696357", "l": "LAIR2 binds collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29385", "l": "2'-deoxyinosine + phosphate => dIMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65195", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A <=> berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10809", "l": "(S)-2-hydroxypropylphosphonate + H2O2 => (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37143", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714483", "l": "RAC2 translocates to the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36484", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71959", "l": "3 Na(+)(out) + oxaloacetate(out) = 3 Na(+)(in) + oxaloacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156682", "l": "PLK1 phosphorylates NUDC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005516", "l": "calmodulin binding", "d": ["Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20260", "l": "3-methyloxindole + NADP(+) <=> 3-methyleneoxindole + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149519", "l": "MMACHC decyanates CNCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950183", "l": "IL12B binds IL23A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20733", "l": "[protein]-dithiol + [thioredoxin]-disulfide => [protein]-disulfide + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70111", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63150", "l": "(9Z)-octadecenoate + taurine => H2O + N-(9Z-octadecenoyl)-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53168", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39113", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38992", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809680", "l": "MTMR12 binds MTM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1901513", "l": "lipo-chitin oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029468", "l": "Conversion of PA into DAG by PAP-1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59807", "l": "L-phenylalanine <=> D-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693198", "l": "RHOD binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63411", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786500", "l": "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42474", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+) => dibenzo-p-dioxin + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70419", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O = 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15579", "l": "D-ribose + uracil => H2O + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35245", "l": "adenosine thiamine triphosphate + phosphate => ADP + H(+) + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14735", "l": "ADP + Ag(+)(out) + H(+) + phosphate => Ag(+)(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202248", "l": "Phosphorylation of PLC-gamma1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.36", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14963", "l": "formate + glutathione + H(+) => H2O + S-formylglutathione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813740", "l": "GDE1 hydrolyzes GroPIns (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40210", "l": "(2E)-tetradecenedioyl-CoA + H2O <=> (3S)-hydroxytetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003948", "l": "N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity", "d": ["Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667619", "l": "AVPR1A,B,2 bind atosiban (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471322", "l": "Beta-defensins are secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70054", "l": "2-oxoadipate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.128", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13658", "l": "acetyl-[citrate lyase ACP] + H2O => acetate + H(+) + holo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76780", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,6-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51919", "l": "(2S)-2-amino-3-butenoate + H2O <=> 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29135", "l": "a menaquinol + 2 H(+)(in) + nitrate = a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043858", "l": "arginine:ornithine antiporter activity", "d": ["Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)."], "t": []}, {"i": "RHEA:34991", "l": "L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633314", "l": "TP53 stimulates NDRG1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71670", "l": "malonate(out) + succinate(in) <=> malonate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22017", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) => arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047828", "l": "D-lyxose ketol-isomerase activity", "d": ["Catalysis of the reaction: D-lyxose = D-xylulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507869", "l": "Aquaporins passively transport glycerol into cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9732629", "l": "PPARG binds PPARG agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18660", "l": "(R)-glycerate + NADP(+) <=> 3-hydroxypyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654409", "l": "Activated FGFR3 binds FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099899", "l": "WNT5A binds FZD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24553", "l": "5alpha-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450550", "l": "PKCalpha phosphorylates HuR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73260", "l": "cirsiliol + S-adenosyl-L-methionine => eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111956", "l": "Calmodulin activates Cam-PDE 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176956", "l": "Formation of GINS complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451900", "l": "IL2RB binds JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963915", "l": "1,25(OH)2D binds VDR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66867", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + quiannulatene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250947", "l": "B-WICH complex binds rDNA promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295599", "l": "SPRY2 translocates to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453183", "l": "p-Y348-SYK dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53355", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20b) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659820", "l": "RB1 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48015", "l": "4-methyl-5-nitrocatechol + NADPH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10393", "l": "(E)-cinnamyl alcohol + NADP(+) => (E)-cinnamaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17460", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine <=> [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47920", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O = ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74366", "l": "coproporphyrin III(out) <=> coproporphyrin III(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18313", "l": "(R)-mandelonitrile = benzaldehyde + hydrogen cyanide", "d": [], "t": []}, {"i": "EC:4.1.2.10", "l": "\"(R)-mandelonitrile lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983266", "l": "Kinesins bind microtubules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58418", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => (E)-4-hydroxynon-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879594", "l": "SLCO4C1 mediates the transport of digoxin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102369", "l": "11alpha-30-dihydroxy beta-amyrin dehydrogenase activity", "d": ["Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ = 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48614", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57792", "l": "3,4-dinitrotoluene + NADH + O2 = 4-methyl-6-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58907", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45232", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050035", "l": "L-sorbose oxidase activity", "d": ["Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38646", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030370", "l": "intercellular adhesion molecule-3 receptor binding", "d": ["Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052720", "l": "class II DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183067", "l": "Localization of CBL:GRB2 to the membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16888", "l": "2 bilirubin-glucuronoside <=> bilirubin IXalpha + bilirubin-bisglucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74391", "l": "methylamine(out) = methylamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21203", "l": "2-oxoglutarate + L-lysine <=> (S)-2-amino-6-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37332", "l": "H2O + L-methionyl-L-alanine => L-alanine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59818", "l": "a sterol ester + CoA => a long-chain fatty acyl-CoA + a sterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052858", "l": "peptidyl-lysine acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32177", "l": "alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661039", "l": "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198669", "l": "p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102607", "l": "3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ = 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67854", "l": "FMN-N(5)-peroxide => FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21090", "l": "a flavonol + CO2 + H2O + succinate => 2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44522", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31986", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60086", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14088", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA <=> 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244614", "l": "cGAS produces cyclic GMP-AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853313", "l": "FGFR2 fusions autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21434", "l": "H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60297", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55848", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72629", "l": "2 H(+)(in) + Zn(2+)(out) => 2 H(+)(out) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0072586", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity", "d": ["Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19201", "l": "2'-deoxyguanosine + ATP = ADP + dGMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617408", "l": "GLI3R binds the GLI1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716947", "l": "ESR1 binds ESR1 agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21008", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.229", "l": "\"diethyl 2-methyl-3-oxosuccinate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25149", "l": "H(+) + H2O + quinolinate => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110218", "l": "Cleavage of uracil by TDG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.496617203483822", "identifiers": [{"i": "GO:0004618", "l": "phosphoglycerate kinase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530445", "l": "CD59 inhibits MAC formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416683", "l": "SEMA3E binds to PLXND1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61449", "l": "H(+) + NADPH + O2 + tigecycline => 11a-hydroxytigecycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47017", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O => [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865994", "l": "GAB1 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193702", "l": "Part of the ICD migrates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64768", "l": "S-3-(hexan-1-ol)-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60320", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63793", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444523", "l": "Formation of MSH1:PMS2 Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22083", "l": "H(+) + NADH + O2 + quinolin-2-ol <=> H2O + NAD(+) + quinoline-2,8-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77071", "l": "(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641205", "l": "RSPO:LGR binds ZNRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75254", "l": "carminate + O2 <=> 3'-dehydrocarminate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140560", "l": "xylosyl alpha-1,3-xylosyltransferase activity", "d": ["Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396399", "l": "Fibrillins bind BMPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12036", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35533", "l": "albonoursin + 2 H2O2 => cyclo(L-phenylalanyl-L-leucyl) + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64431", "l": "glycyl-L-proline(out) + H(+)(out) <=> glycyl-L-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23184", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44508", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48159", "l": "a ganglioside GQ1b (d18:1(4E)) + H2O <=> a ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62717", "l": "stemphyloxin I => stemphyloxin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689111", "l": "PARK2 autoubiquitinates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24366", "l": "2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50168", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53832", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112430", "l": "Formation of P-TEFb complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627106", "l": "SMAC (DIABLO) forms dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17251", "l": "6 H(+) + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 2 H2O + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50186", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53016", "l": "chlorohydroquinone + 2 glutathione = chloride + glutathione disulfide + H(+) + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50413", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] => H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20556", "l": "(R)-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56398", "l": "(3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33719", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.7", "l": "\"ribonuclease F\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56812", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 = 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.15", "l": "\"L-threonyl-[L-threonyl-carrier protein] 4-chlorinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33520", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine => (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12958", "l": "an acetyl ester + H2O => acetate + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28818", "l": "4-hydroxybenzoate(in) + H(+)(out) <=> 4-hydroxybenzoate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835454", "l": "DNAJC3 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18279", "l": "a methyl thioether + H(+) + S-adenosyl-L-homocysteine => a thiol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52462", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33711", "l": "4-sulfomuconolactone + H2O = 2 H(+) + maleylacetate + sulfite", "d": [], "t": []}, {"i": "EC:3.1.1.92", "l": "\"4-sulfomuconolactone hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120295", "l": "histone serotonyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23192", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381608", "l": "cAMP activates EPAC2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61542", "l": "ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43682", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877281", "l": "PIAS1 binds p-STAT1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247839", "l": "Retromer associates with WLS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37037", "l": "2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-2-aminopentanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.32", "l": "\"endo-1,3-beta-xylanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749286", "l": "CDT1 binds MCM2-7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102277", "l": "2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity", "d": ["Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14841", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.13", "l": "\"ent-copalyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28261", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate <=> cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29866", "l": "AMP + GTP <=> ADP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334827", "l": "SUMO-CRABP2 binds atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706354", "l": "Ubiquitination of FLT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23553", "l": "2-methylpropane-1,2-diol + NAD(+) => 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20691", "l": "(E)-caffeate + H(+) + L-quinate => chlorogenate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856951", "l": "PP2A demethylation by PPME1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691154", "l": "HFE binds TFRC dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47028", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine = [DsrC protein]-disulfide + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32558", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-alpha-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68135", "l": "phytol + tetradecanoyl-CoA <=> CoA + tetradecanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203613", "l": "depalmitoylation of eNOS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20521", "l": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.30", "l": "\"3-hydroxybutyrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737780", "l": "MTTP binds lomitapide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047971", "l": "guanidinobutyrase activity", "d": ["Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51893", "l": "H2O + N-acetylcadaverine => acetate + cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59025", "l": "H2O + trihexadecanoylglycerol => dihexadecanoylglycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12507", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57595", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41834", "l": "hexanoyl-[ACP] + NADP(+) => (2E)-hexenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76723", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 5-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77554", "l": "(9Z)-octadecenoyl-CoA + 3-octadecanoyl-sn-glycerol <=> 1-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21126", "l": "5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74339", "l": "O-3-methylbutanoyl-(R)-carnitine(in) = O-3-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76613", "l": "4-hydroxy-3-methoxy-benzenemethanol + NADP(+) => H(+) + NADPH + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57302", "l": "a 2'-deoxyguanosine in DNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0032813", "l": "tumor necrosis factor receptor superfamily binding", "d": ["Binding to a member of the tumor necrosis factor receptor superfamily."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77043", "l": "5-hydroxyoctan-4-amine + H2O + NAD(+) = 5-hydroxyoctan-4-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001965", "l": "G-protein alpha-subunit binding", "d": ["Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50591", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017005", "l": "3'-tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31658", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140487", "l": "metal ion sequestering activity", "d": ["Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67944", "l": "2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204873", "l": "Interaction of Tie2 and Shp2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180014", "l": "protein-tRNA adaptor activity", "d": ["The binding activity of a protein that brings together another protein and a tRNA, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804266", "l": "CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990576", "l": "G protein-coupled glucose receptor activity", "d": ["Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034004", "l": "germacradienol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849908", "l": "SALM4 binds flotillin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45600", "l": "D-galactaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19459", "l": "catechol + H2O + 2 NADP(+) + nitrite => 2-nitrophenol + 2 H(+) + 2 NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22963", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840488", "l": "PSAP(195-273) forms a dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69619", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16413", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}, {"i": "EC:2.3.1.200", "l": "\"lipoyl amidotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48285", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => a globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62811", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.14.1", "l": "\"yeast ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57124", "l": "2-oxoglutaramate = 2-hydroxy-5-oxoproline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18582", "l": "ethanolamine + H2O + O2 => glycolaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68131", "l": "a fatty acyl-CoA + phytol <=> a fatty acid phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835443", "l": "STAT1,STAT3 binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112690", "l": "PTPN11 binds CBL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72185", "l": "mRNA polyadenylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67514", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007901", "l": "IL1F10 binds IL1RL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030744", "l": "luteolin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68595", "l": "ORC2 binds ORC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617887", "l": "HOXC4 chromatin is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33301", "l": "[eIF5A protein]-deoxyhypusine + propane-1,3-diamine => [eIF5A protein]-L-lysine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41647", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.62", "l": "\"D-ribose pyranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70691", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50471", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39815", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036185", "l": "13-lipoxin reductase activity", "d": ["Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+."], "t": []}, {"i": "REACT:R-HSA-2161844", "l": "15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11908", "l": "H2O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one", "d": [], "t": []}, {"i": "EC:3.7.1.7", "l": "\"beta-diketone hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34333", "l": "(indol-3-yl)acetate + CO2 + H2O + NADP(+) => H(+) + indole-3-pyruvate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113449", "l": "RNA Polymerase III Transcriptional Pause at Terminator Sequence (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018325", "l": "ESR1:ESTG binds CXXC5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932184", "l": "Expression of HIGD1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18175", "l": "(4-hydroxyphenyl)acetaldehyde + NH4(+) => (R)-octopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29246", "l": "H(+) + menaquinone-8 + NADH <=> menaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16333", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]", "d": [], "t": []}, {"i": "EC:2.7.7.61", "l": "\"citrate lyase holo-[acyl-carrier protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23096", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.49", "l": "\"hydroxymethylpyrimidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44626", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45938", "l": "4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA => 3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033839", "l": "flavonol-3-O-glycoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0141109", "l": "transporter activator activity", "d": ["Binds to and increases the activity of a transporter."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507873", "l": "Aquaporins passively transport urea out of cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49622", "l": "D-erythrulose 1-phosphate + H(+) + NADPH => D-erythritol 1-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111962", "l": "PDE4A,C,D hydrolyse cAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718379", "l": "GNRHR binds chemical antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51666", "l": "H(+) + N-carbamoyl-D-phenylglycine => D-5-phenylhydantoin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38311", "l": "carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.292", "l": "\"carminomycin 4-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046972", "l": "histone H4K16 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090438", "l": "camelliol C synthase activity", "d": ["Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32997", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69777", "l": "beta-ylangene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33362", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170978", "l": "p-FRS2:CRKL binds C3G (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45954", "l": "H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60159", "l": "ATP + D-galactose(out) + H2O <=> ADP + D-galactose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62549", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77297", "l": "a ganglioside GT3 + CMP + H(+) => a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.41", "l": "\"3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446077", "l": "BP230 interacts with keretin K5/K14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008431", "l": "vitamin E binding", "d": ["Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866277", "l": "AP-2 directly binds some endocytic cargo (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54199", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16137", "l": "2'-deoxymugineate + NADP(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54013", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102583", "l": "cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA = cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62531", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19603", "l": "2,3,5-trihydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72891", "l": "acetylcholine(out) + 2 H(+)(in) = acetylcholine(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205244", "l": "Recruitment of CBL to KIT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12389", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696547", "l": "STAMBPL1 is a deubiquitinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694344", "l": "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52394", "l": "4-phospho-D-erythronate + ADP + H(+) => ATP + D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20759", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate <=> 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42661", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69417", "l": "H(+) + H2O2 + thiocyanate => H2O + hypothiocyanous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294574", "l": "Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799350", "l": "Exocytosis of specific granule membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901982", "l": "maltose binding", "d": ["Binding to maltose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688786", "l": "ATXN3 binds RAD23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73842", "l": "ATP + H2O + phenol <=> AMP + 2 H(+) + phenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66585", "l": "3-oxocholestane + A + H2O => 25-hydroxy 3-oxocholestane + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848864", "l": "PTK6 binds ARAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62464", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66302", "l": "an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40637", "l": "2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947647", "l": "GHSR is a receptor for ghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847537", "l": "RAB43:GTP binds USP8NL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26068", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O = CoA + H(+) + phosphinomethylmalate", "d": [], "t": []}, {"i": "EC:2.3.3.18", "l": "\"2-phosphinomethylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22211", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000319", "l": "BORA binds PLK1 and AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53205", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55942", "l": "all-trans-3,4-didehydroretinal + H(+) + NADH => all-trans-3,4-didehydroretinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686587", "l": "ABL1 phosphorylates RAD52 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56578", "l": "a globoside Gb4Cer + H(+) + UDP => a globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015095", "l": "magnesium ion transmembrane transporter activity", "d": ["Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60669", "l": "(R,R)-chrysanthemol + NAD(+) => (1R,3R)-chrysanthemal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63623", "l": "ATP + dodecanoate + holo-[ACP] <=> AMP + diphosphate + dodecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870466", "l": "RGGT:CHM binds RABs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50850", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004359", "l": "glutaminase activity", "d": ["Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422088", "l": "Expression of Preproghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22164", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.88", "l": "\"globoside alpha-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26545", "l": "(R)-piperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47817", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73978", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696491", "l": "CNTF binds CNTFR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66964", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.379", "l": "\"GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.30", "l": "\"receptor protein serine/threonine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.5", "l": "\"prenylcysteine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68921", "l": "ATP + H(+) + NADPH + pentanoate => AMP + diphosphate + NADP(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55901", "l": "chloride + FADH2 + L-tryptophan + O2 => 6-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11805", "l": "an aromatic aldehyde + H2O + NAD(+) => an aromatic carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30029", "l": "glycerol + NAD(+) => D-glyceraldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46470", "l": "ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate => an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24968", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12330", "l": "[(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate => [(1->3)-alpha-D-glucosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44717", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O => AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64196", "l": "an N-(fatty acyl)-L-lysine + H2O = a fatty acid + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.540281582338167", "identifiers": [{"i": "GO:0008170", "l": "N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173626", "l": "Activation of C1r (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0016636", "l": "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.3.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33000", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103016", "l": "tRNA-specific 2-thiouridylase activity", "d": ["Catalysis of the reaction: ATP + H+ + a tRNA uridine34 + a [TusE sulfur carrier protein]-S-sulfanylcysteine = AMP + diphosphoric acid + a tRNA 2-thiouridine34 + a [TusE sulfur carrier protein]-L-cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11922", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H2O => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160089", "l": "internal N(7)-methylguanine-containing RNA reader activity", "d": ["A protein adaptor that recognizes and binds an RNA molecule modified by N(7)-methylguanine (m7G), a modification present at internal sites of mRNAs and some non-coding RNAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.15", "l": "\"3-(aryl)acrylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69327", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75964", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione => 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030976", "l": "thiamine pyrophosphate binding", "d": ["Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176445", "l": "SMURF2 binds SMAD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10670", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140037", "l": "sumo-dependent protein binding", "d": ["Binding to a protein upon sumoylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950766", "l": "IL27RA dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57545", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874191", "l": "CREB3L2 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37657", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40850", "l": "eicosanoyl-CoA + FAD + H(+) <=> (2E)-eicosenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49086", "l": "(-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170120", "l": "Translocation of Cdc25B to the cytoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019181", "l": "halohydrin hydrogen-halide-lyase activity", "d": ["Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004150", "l": "dihydroneopterin aldolase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43102", "l": "2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(44) in tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64403", "l": "an L-amino acid tripeptide(out) + H(+)(out) <=> an L-amino acid tripeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2219524", "l": "PDPK1 binds PIP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012086", "l": "Constitutive dimerization of FGFR4 Y367C mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58827", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003828", "l": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362427", "l": "Hh-Np binds GPC5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018762", "l": "aliphatic nitrilase activity", "d": ["Catalysis of the reaction: R-CN + H2O = R-COOH + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40721", "l": "an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+) => an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203977", "l": "SAR1 Activation And Membrane Binding (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16192", "l": "3-(4-hydroxyphenyl)pyruvate + O2 <=> CO2 + homogentisate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67230", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18328", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-amorpha-4,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58514", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56575", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose <=> a globoside Gb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34142", "l": "Delta(9)-tetrahydrocannabinolate + H(+) <=> CO2 + Delta(9)-tetrahydrocannabinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72140", "l": "estrone 3-sulfate(in) + H(+)(out) => estrone 3-sulfate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45216", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] = Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61757", "l": "stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22891", "l": "(R)-methylmalonyl-CoA <=> succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60166", "l": "an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine => a guanosine in RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62660", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol = (2'R)-atrovenetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68412", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) = 2 H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45009", "l": "H2O + N-(octadecanoyl)-sphinganine => octadecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32335", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) = (1S,4R)-fenchone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159773", "l": "Furin cleaves pro-protein S to protein S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63121", "l": "(11Z)-eicosenamide + H2O => (11Z)-eicosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51005", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] => an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047925", "l": "geranoyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374664", "l": "Phosphorylation and activation of Ezrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29928", "l": "(R)-pantothenate(in) + Na(+)(in) => (R)-pantothenate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68565", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22044", "l": "ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.19", "l": "\"H(+)/K(+)-exchanging ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47509", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => isolithocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16238", "l": "[protein]-peptidylproline (omega=180) => [protein]-peptidylproline (omega=0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32374", "l": "all-trans-violaxanthin + 2 L-ascorbate <=> all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36356", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672951", "l": "Inactive RAFs bind YWHAB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622357", "l": "PIKE-L interaction with UNC5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57482", "l": "2,3-dihydroxydodecanoate + H2O => 2-hydroxydodecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607734", "l": "PKC-delta translocates to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362416", "l": "Frataxin binds iron (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61388", "l": "ATP + biotin(in) + H2O = ADP + biotin(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55414", "l": "[phosphate](n+1) + GDP => [phosphate](n) + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928620", "l": "PAK1 autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836702", "l": "PKR inhibitors bind PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21236", "l": "anthranilate + 2 H(+) + NADPH + O2 = 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": [], "t": []}, {"i": "EC:1.14.13.35", "l": "\"anthranilate 3-monooxygenase (deaminating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69544", "l": "ATP + streptidine = 6-O-adenylylstreptidine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46477", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11641", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050152", "l": "omega-amidase activity", "d": ["Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624952", "l": "Assembly of the retrograde IFT train (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696183", "l": "AOC3 deaminates BZAM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24292", "l": "acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate", "d": [], "t": []}, {"i": "EC:2.3.1.1", "l": "\"amino-acid N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667914", "l": "ALK binds ligand midkine (MDK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34140", "l": "Delta(9)-tetrahydrocannabinolate + H(+) => CO2 + Delta(9)-tetrahydrocannabinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247837", "l": "WNT ligands traffic to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45489", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17449", "l": "(2E)-geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.123", "l": "\"flaviolin linalyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12756", "l": "glycerol + NADP(+) <=> dihydroxyacetone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25511", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-sabinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202248", "l": "Phosphorylation of PLC-gamma1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928627", "l": "EPHB phosphorylates TIAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21111", "l": "(S)-3-methyl-2-oxopentanoate + H(+) <=> 2-methylbutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952996", "l": "E2F7 forms homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70156", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36562", "l": "A + cis-4-hydroxy-D-proline <=> 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444047", "l": "Receptor FFAR3 binds carboxylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57563", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799097", "l": "ATM phosphorylates ZNF420 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16429", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}, {"i": "EC:6.3.2.9", "l": "\"UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103077", "l": "quercetin 3-glucoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose = quercetin-3-O-glucoside-7-O-rhamnoside + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65828", "l": "H2O + neryl diphosphate = diphosphate + nerol", "d": [], "t": []}, {"i": "EC:3.1.7.13", "l": "\"neryl diphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31453", "l": "a cardiolipin + glycerol => 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44961", "l": "(2E)-decenoyl-CoA + H(+) + NADPH => decanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74258", "l": "XDH oxidizes xanthine to form urate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25853", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32212", "l": "(Z)-5-oxohex-2-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.16.1", "l": "\"spleen exonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39455", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201341", "l": "Endocytosis of TRAM (TICAM2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23810", "l": "(S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13434", "l": "2'-deoxycytidine + H(+) + H2O => 2'-deoxyuridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855232", "l": "RELN:VLDLR binds DAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390438", "l": "FAR2 reduces PalmCoA to HXOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68443", "l": "beta-cryptoxanthin + O2 <=> (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035013", "l": "myosuppressin receptor activity", "d": ["Combining with the peptide myosuppressin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58103", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O <=> (15Z)-tetracosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50093", "l": "a fatty acyl-CoA + taurine => an N-fatty acyl-taurine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13751", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-triphosphate + AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20323", "l": "1-pyrroline-2-carboxylate + H(+) + NADH => L-proline + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450723", "l": "RAC1:GTP and MSN activate HEP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617650", "l": "HOXD3 chromatin is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173317", "l": "C3a anaphylatoxin binds C3a receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64486", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA => acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12511", "l": "loganate + S-adenosyl-L-methionine <=> loganin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23126", "l": "CO2 + D-ribulose 1,5-bisphosphate + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018804", "l": "RAC3 GEFs activate RAC3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60481", "l": "2 UTP => c-di-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193684", "l": "p62 recruits an atypical PKC (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42101", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12925", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] = H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62832", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30824", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56770", "l": "2 A + all-trans-adonixanthin + 3 H2O => 2 AH2 + all-trans-zeaxanthin + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.875378082774276", "identifiers": [{"i": "GO:0005126", "l": "cytokine receptor binding", "d": ["Binding to a cytokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53118", "l": "an 11-oxosteroid + H(+) + NADH => an 11beta-hydroxysteroid + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45611", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48060", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19883", "l": "diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein] => GTP + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49949", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043720", "l": "3-keto-5-aminohexanoate cleavage activity", "d": ["Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28125", "l": "ATP + di-trans,octa-cis-undecaprenol <=> ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15179", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22193", "l": "(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.028446044353302", "identifiers": [{"i": "GO:0008483", "l": "transaminase activity", "d": ["Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.27", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50754", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O => 2 naphthalene-1,2,4,8-tetrol + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58477", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39432", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0051748", "l": "UTP-monosaccharide-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626914", "l": "α2-agonists bind ADRA2A,B,C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55258", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38710", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12773", "l": "2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55510", "l": "11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102726", "l": "DIMBOA glucoside beta-D-glucosidase activity", "d": ["Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56635", "l": "H2O + neryl diphosphate <=> 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106149", "l": "indole-3-carbonyl nitrile 4-hydroxylase activity", "d": ["Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP+ + H20."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18784", "l": "H(+) + malonyl-CoA <=> acetyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953013", "l": "E2F7 binds E2F8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72032", "l": "(E)-sinapyl alcohol + O2 => (E)-sinapaldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-555065", "l": "Formation of clathrin coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53444", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.77", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40613", "l": "2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate => H2O + trihexanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66398", "l": "ADP + cholate(out) + glutathione(out) + H(+) + phosphate => ATP + cholate(in) + glutathione(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250947", "l": "B-WICH complex binds rDNA promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029680", "l": "Caspase-7 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56739", "l": "H2O + O2 + retinal <=> H(+) + H2O2 + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18785", "l": "A + gibberellin A12 aldehyde + H2O = AH2 + gibberellin A12 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73895", "l": "ATP + L-glutamate + spermine = ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15266", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate => H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10589", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH => 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55838", "l": "calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcitriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77436", "l": "a ganglioside GT1c + CMP-N-acetyl-beta-neuraminate => a ganglioside GQ1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36036", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424484", "l": "Phosphorylation of BTK by p-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75508", "l": "n H(+)(out) + taurocholate(out) => n H(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697084", "l": "Defective rpoB in Mtb RNAP transcribes RNA polyanion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603467", "l": "Activated protein C is released from PROCR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49572", "l": "Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)", "d": [], "t": []}, {"i": "EC:4.99.1.9", "l": "\"coproporphyrin ferrochelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47518", "l": "isochenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003952", "l": "NAD+ synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27739", "l": "2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042962", "l": "acridine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0016872", "l": "intramolecular lyase activity", "d": ["The catalysis of certain rearrangements of a molecule to break or form a ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627775", "l": "Autophosphorylation of PAK1,2,3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429767", "l": "Passive I- efflux mediated by SMCT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36111", "l": "gibberellin A1 + S-adenosyl-L-methionine = O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70657", "l": "H(+)(out) + sarcosine(out) => H(+)(in) + sarcosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41632", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950063", "l": "IL12RB2 binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928607", "l": "p-EPHs bind VAV2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698927", "l": "Assembly of the HCMV Genome DNA Replication Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20798", "l": "D-ribulose => aldehydo-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23397", "l": "H2O + phloretin => 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33072", "l": "D-glucose 6-phosphate => 2-deoxy-L-scyllo-inosose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182279", "l": "Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956568", "l": "RUNX1 binds the core TAL1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714483", "l": "RAC2 translocates to the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17684", "l": "3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700190", "l": "ALK mutants bind SHC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13173", "l": "H2O + NAD(+) + phosphonate = H(+) + NADH + phosphate", "d": [], "t": []}, {"i": "EC:1.20.1.1", "l": "\"phosphonate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63260", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH = 4-pyridoxate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41520", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76416", "l": "Benzene is hydroxylated to phenol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60570", "l": "N-acetyl-D-tryptophan => N-acetyl-L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803063", "l": "RNASEs bind bacterial LPS, PGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.33", "l": "\"RCR-type E3 ubiquitin transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23925", "l": "pppGp(2'-5')A => 2',3'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622310", "l": "Activated NOD1 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25890", "l": "H(+) + 2 H2O + phosphate + quinolinate => dihydroxyacetone phosphate + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28877", "l": "H(+)(out) + L-tyrosine(out) => H(+)(in) + L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102549", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O = sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30415", "l": "H(+) + 2 NADPH + O2 + octadecanal = formate + H2O + heptadecane + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63630", "l": "AMP + diphosphate + hexadecanoyl-[ACP] => ATP + hexadecanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693575", "l": "DNA-PKcs autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61817", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose => 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112396", "l": "Separation of elongating transcript from template (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21850", "l": "(Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674095", "l": "PDGFRs bind type II TKI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48423", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM1 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65851", "l": "A + a 3-oxo-Delta(1)-steroid + H2O <=> a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380782", "l": "STAT binds to the active receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433418", "l": "Phosphorylation of JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421835", "l": "trans-Golgi Network Vesicle Scission (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614367", "l": "HCMV Nuclear Pore Docking (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44687", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129357", "l": "Fibrillin C-terminal processing (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54761", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761065", "l": "FOXF1 binds CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602484", "l": "Activation of proMMP11 by FURIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44659", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806610", "l": "Keratin filament formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57372", "l": "H2O + NADPH = (6S)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391935", "l": "DP1 receptor can bind PGD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75572", "l": "acetyl-CoA + cyathin A3 => 11-O-acetylcyathin A3 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37570", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48314", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40595", "l": "dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050256", "l": "ribitol-5-phosphate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26026", "l": "8'-apo-beta-carotenol + O2 <=> (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336422", "l": "Clathrin-mediated endocytosis of DT:HBEGF:CD9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42542", "l": "pseudouridine(13) in tRNA => uridine(13) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45045", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 => 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24813", "l": "2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13144", "l": "2-methylpropanoyl-CoA <=> butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935980", "l": "RUNX1 binds the OCLN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795290", "l": "TORC2 complex phosphorylates SGK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.53", "l": "\"lytic chitin monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51242", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11355", "l": "acetate + ATP <=> acetyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.128", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24962", "l": "[excited state blue fluorescent protein] + CO2 => apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106614", "l": "Duplex miRNA is loaded into Argonaute (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48925", "l": "a ganglioside GM4 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832183", "l": "Expression of IRX1 during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045435", "l": "lycopene epsilon cyclase activity", "d": ["Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37897", "l": "26-deglucoprotodioscin + D-glucose => H2O + protodioscin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15265", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": [], "t": []}, {"i": "EC:2.6.99.2", "l": "\"pyridoxine 5'-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62719", "l": "stemphyloxin I <=> stemphyloxin II", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32343", "l": "(+)-thujan-3-ol + NAD(+) = (+)-thujan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36440", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018766", "l": "RHOU binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353243", "l": "Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704297", "l": "CHRM2 binds CHRM2 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56589", "l": "a monosubstituted aliphatic (S)-hydroxynitrile => an aldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905108", "l": "guanosine binding", "d": ["Binding to guanosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187588", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52371", "l": "3'-phosphoadenylyl sulfate + cholesterol <=> adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26309", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.28", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67376", "l": "glycyl-L-histidine + H2O = glycine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20517", "l": "UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}, {"i": "EC:5.1.3.7", "l": "\"UDP-N-acetylglucosamine 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43178", "l": "5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51217", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one => adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.-.-", "l": "\"Acting on a sulfur group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.5", "l": "\"peptidyl-dipeptidase Dcp\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57788", "l": "1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47485", "l": "deoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38186", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593690", "l": "Phosphorylation of PLCgamma by Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.44", "l": "\"homospermidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23573", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisovalerophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684096", "l": "CDK2 phosphorylates RBBP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65730", "l": "CO2 + H(+) + hexanal + succinate + sulfate => 2-oxoglutarate + hexyl sulfate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60112", "l": "(R)-3-(indol-3-yl)lactoyl-CoA = (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76161", "l": "fluoride(out) => fluoride(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.45", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30733", "l": "(2E)-butenoyl-CoA + FADH2 => butanoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39443", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72194", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.110", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803890", "l": "SFN dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62479", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73472", "l": "D-ornithine(in) + L-ornithine(out) => D-ornithine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35012", "l": "D-fucose(in) + H(+)(in) => D-fucose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22777", "l": "2 H(+) + H2O2 + 2 Mn(2+) => 2 H2O + 2 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59221", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36481", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465924", "l": "OPN1LW binds 11cRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37024", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74187", "l": "S-adenosyl-L-methionine + taxifolin = H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38680", "l": "ATP + H2O + sphinganine(in) => ADP + H(+) + phosphate + sphinganine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371518", "l": "SIRT1 binds to HSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60874", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433786", "l": "Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47681", "l": "D-galactosamine 6-phosphate + H2O => D-tagatopyranose 1-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64743", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48289", "l": "a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate => a ganglioside GD3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204850", "l": "Interaction of Tie2 and Dok-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018768", "l": "RHOU auto-activates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29891", "l": "ATP + H2O + L-histidine(out) = ADP + H(+) + L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60791", "l": "gibberellin A24 + H(+) + O2 <=> CO2 + gibberellin A9 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033836", "l": "flavonol 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29730", "l": "ethane-1-sulfonate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404134", "l": "RBP4:atROL binds TTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61894", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51651", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626220", "l": "C2CD3 binds the mother centriole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595175", "l": "Defective CHST3 does not transfer SO4(2-) to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21229", "l": "alpha-maltose => beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509831", "l": "ITPA hydrolyses XTP to XMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63329", "l": "2-(9Z-octadecenoyl)-glycerol + ATP => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0005229", "l": "intracellular calcium activated chloride channel activity", "d": ["Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794354", "l": "NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382061", "l": "Extracellular processing of novel PDGFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050400", "l": "xylitol kinase activity", "d": ["Catalysis of the reaction: ATP + xylitol = ADP + 2 H+ + xylitol 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21969", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 3-dehydroquinate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18644", "l": "a menaquinone + H2 <=> a menaquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72836", "l": "3',3'-cUAMP + H2O => H(+) + U[3'-5']pAp[3']", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16046", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52905", "l": "15,17(3)-seco-F430-17(3)-acid + ATP => ADP + coenzyme F430 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10615", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60972", "l": "hexan-1-ol + NAD(+) = H(+) + hexanal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67050", "l": "A + asnovolin I + H2O => AH2 + chermesin D + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.147", "l": "\"16alpha-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47202", "l": "(24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH => (24S)-7alpha-dihydroxycholesterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64769", "l": "S-3-(hexan-1-ol)-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11817", "l": "alpha-D-glucose 6-phosphate => beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71630", "l": "phosphate(in) + succinate(out) <=> phosphate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052626", "l": "benzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847880", "l": "CYTH proteins bind ARF1:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48328", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800298", "l": "HGF dimer binds MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31261", "l": "3-butynoate + 2 H(+) + NADH => but-3-ynal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000774", "l": "adenyl-nucleotide exchange factor activity", "d": ["Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins."], "t": []}, {"i": "REACT:R-HSA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508282", "l": "SYK is a substrate for JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27441", "l": "NAD(+) + xylitol = D-xylose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050325", "l": "tauropine dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + tauropine = H+ + NADH + pyruvate + taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47633", "l": "H2O + L-arginine + NAD(+) => 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-532549", "l": "MPI isomerises Fru6P to Man6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19132", "l": "ATP + thymidine <=> ADP + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371554", "l": "HSF1 acetylation at Lys80 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21373", "l": "H(+) + H2O + urethane => CO2 + ethanol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045127", "l": "N-acetylglucosamine kinase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730841", "l": "Phosphorylation and activation of VAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167511", "l": "HLCS biotinylates ACACB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59366", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+) => 1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75138", "l": "NADP(+) + neopine <=> H(+) + NADPH + neopinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56446", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34659", "l": "C30 botryococcene + S-adenosyl-L-methionine = 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17653", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.29", "l": "\"geranylgeranyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21273", "l": "ATP + glutathione + spermidine => ADP + glutathionylspermidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759158", "l": "SQSTM1 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36633", "l": "(2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+) => D-ribulose 1,5-bisphosphate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21320", "l": "A + D-sorbitol = AH2 + keto-L-sorbose", "d": [], "t": []}, {"i": "EC:1.1.99.21", "l": "\"D-sorbitol dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77077", "l": "Capping complex formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66673", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) => 5,7-dihydroxy-4-methylphthalide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31894", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350598", "l": "Arginine<=>Agmatine+CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434084", "l": "p-IRAK2- TRAF6 dissociates from the activated chTLR complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16702", "l": "17alpha-estradiol + NAD(+) => estrone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72037", "l": "ATP(in) + 2 H(+)(in) + phosphate(out) => ATP(out) + 2 H(+)(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050108", "l": "monoterpenyl-diphosphatase activity", "d": ["Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848596", "l": "PTK6 binds PXN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975633", "l": "atROL binds to RBP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052641", "l": "benzoic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004392", "l": "heme oxygenase (decyclizing) activity", "d": ["Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944257", "l": "Association of procollagen type XXIV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618093", "l": "ATP hydrolysis by HSP90 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322431", "l": "XIAP binds TLE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16933", "l": "1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.7", "l": "\"1-aminocyclopropane-1-carboxylate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69701", "l": "beta-D-glucose + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956684", "l": "ITCH polyubiquitinates TP73 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019810", "l": "putrescine binding", "d": ["Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802932", "l": "Dissociation of BRAF/RAF fusion complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64793", "l": "L-lysine + NADP(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176956", "l": "Formation of GINS complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61106", "l": "(2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008480", "l": "sarcosine dehydrogenase activity", "d": ["Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28319", "l": "scutellarein + UDP-alpha-D-glucuronate => scutellarin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419166", "l": "GEFs activate RhoA,B,C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46358", "l": "18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + octadecanoate + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27316", "l": "2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+) => dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726509", "l": "NR3C2 binds fludrocortisone (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59601", "l": "5-methoxytryptamine + H2O + O2 => 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25490", "l": "(1S,5S)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.36", "l": "\"caspase-1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937177", "l": "AHR:TCDD binds ARNT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419157", "l": "5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26013", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482770", "l": "Release of platelet secretory granule components (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362522", "l": "ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62145", "l": "dGMP + dGTP => 2 dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35662", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose <=> GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77614", "l": "2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) <=> 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688834", "l": "ATXN3 binds VCP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172666", "l": "RB1 binds condensin II (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097748", "l": "3'-5' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end."], "t": []}, {"i": "RHEA:57528", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67768", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374675", "l": "L1 dimer binds Ankyrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58818", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59278", "l": "D-glutamine => L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57989", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11868", "l": "D-arabinitol + NADP(+) = D-ribulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814094", "l": "ARL1:GTP binds ARFIP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047725", "l": "inulosucrase activity", "d": ["Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396382", "l": "NOTCH1 Coactivator Complex binds promoters of HEY genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12707", "l": "[protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine => [protein]-L-isoaspartate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70972", "l": "D-dopa + H2O + O2 => 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061676", "l": "importin-alpha family protein binding", "d": ["Binding to a member of the importin-alpha family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043818", "l": "precorrin-3B synthase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + precorrin-3A = H2O + NAD+ + precorrin-3B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178178", "l": "PP1 dephosphorylates TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47762", "l": "a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 21S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72620", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036122", "l": "BMP binding", "d": ["Binding to a member of the bone morphogenetic protein (BMP) family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73962", "l": "2-methoxy-4-vinylphenol + H(+) + NADH <=> 4-ethyl-2-methoxyphenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63222", "l": "5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047602", "l": "acetoacetate decarboxylase activity", "d": ["Catalysis of the reaction: acetoacetate + H+ = acetone + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102586", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32245", "l": "D-ribulose 1,5-bisphosphate => alpha-D-ribose 1,5-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25225", "l": "L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73574", "l": "(E,E)-piperate + ATP + CoA <=> (E,E)-piperoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.75", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33467", "l": "5-dehydroepisterol + H(+) + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22578", "l": "an N-acyl-L-homoserine + H(+) => an N-acyl-L-homoserine lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68368", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36126", "l": "gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76456", "l": "O-atom dealkylation of dextromethorphan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57830", "l": "2-deoxy-D-ribose 5-phosphate + hypoxanthine => dIMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36581", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => dTDP-alpha-D-fucose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774496", "l": "PAX2 binds the LHX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77254", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850831", "l": "KLK5 cleaves and activates KLK8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45376", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675198", "l": "Activated MAPKs phosphorylate BRAF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672961", "l": "PP2A dephosphorylates inactive RAFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64677", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol => butyl 3-(methylsulfanyl)propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25885", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine => H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70338", "l": "2-carboxy-L-lyxonolactone + H2O <=> 2-carboxy-L-lyxonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004948", "l": "calcitonin receptor activity", "d": ["Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55796", "l": "H(+) + NADH + O2 + phenol = H2O + hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019114", "l": "catechol dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = a muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66821", "l": "ATP + H2O + Mn(2+)(in) => ADP + H(+) + Mn(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69141", "l": "N-(4-aminobutyl)-3-aminopropanal => acrolein + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23489", "l": "1,4-benzoquinone + H(+) + NADPH => hydroquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27435", "l": "glutathione amide disulfide + H(+) + NADH => 2 glutathione amide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047521", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity", "d": ["Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327733", "l": "FN1 binds Collagen types I-V, VII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20270", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate => 2 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74723", "l": "Endosome acidification (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480470", "l": "Expression of ZIC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66361", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37877", "l": "methyl aklanonate + S-adenosyl-L-homocysteine => aklanonate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.16", "l": "\"glucosinolate gamma-glutamyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67851", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433957", "l": "Activation of recruited TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31200", "l": "(3S)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47724", "l": "glutathione = 5-oxo-L-proline + L-cysteinylglycine", "d": [], "t": []}, {"i": "EC:4.3.2.7", "l": "\"glutathione-specific gamma-glutamylcyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63708", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11743", "l": "2 glutathione + NADP(+) <=> glutathione disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202245", "l": "Phosphorylation of TBSMs in LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174446", "l": "Removal of remaining Flap from the C-strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51913", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202248", "l": "Phosphorylation of PLC-gamma1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800380", "l": "PTPRD binds IL1RAP-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23251", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036050", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68516", "l": "(2Z,6Z)-farnesyl diphosphate = beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24162", "l": "D-galacto-hexodialdose + H2O2 => D-galactose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592436", "l": "Initial activation of proMMP9 by MMPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57675", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] <=> 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008748", "l": "N-ethylmaleimide reductase activity", "d": ["Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465924", "l": "OPN1LW binds 11cRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008687", "l": "3,4-dihydroxyphenylacetate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0031491", "l": "nucleosome binding", "d": ["Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57706", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000515", "l": "aspartate:glutamate, proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in)."], "t": []}, {"i": "RHEA:70783", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23857", "l": "H(+) + Hg + NADP(+) => Hg(2+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983147", "l": "Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28091", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72969", "l": "4-methyl-2-oxopentanoate(in) + 2 Na(+)(in) => 4-methyl-2-oxopentanoate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660816", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62173", "l": "an N-acylethanolamine phosphate + H2O => an N-acylethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61377", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41547", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019775", "l": "FAT10 transferase activity", "d": ["Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40934", "l": "2-oxoglutarate + L-ornithine + O2 <=> (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.12", "l": "\"envelysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63737", "l": "2-phenylacetaldehyde + H(+) + NADPH => 2-phenylethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50429", "l": "methanethiol + S-adenosyl-L-methionine => dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653886", "l": "B4GALT1 binds LALBA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214857", "l": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68626", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851352", "l": "CCR8 binds CCL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54785", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52293", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65608", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42748", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.176", "l": "\"16S rRNA (cytosine(967)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24319", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046577", "l": "long-chain-alcohol oxidase activity", "d": ["Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420977", "l": "Ca permeable AMPA receptor ligand binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58056", "l": "hypotaurine + pyruvate = 2-sulfinoacetaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033974", "l": "nucleoside phosphoacylhydrolase activity", "d": ["Catalysis of the hydrolysis of mixed phospho-anhydride bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28689", "l": "orotate + ubiquinol-8 => (S)-dihydroorotate + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018758", "l": "2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity", "d": ["Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0016855", "l": "racemase and epimerase activity, acting on amino acids and derivatives", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid."], "t": []}, {"i": "EC:5.1.1.-", "l": "\"Acting on amino acids and derivatives\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39074", "l": "dodecanedioyl-CoA + O2 <=> (2E)-dodecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618725", "l": "SOX10, EGR2 and NAB proteins bind the GJB1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48849", "l": "(9Z,12Z)-octadecadienoate + O2 => 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74059", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43265", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA => 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18091", "l": "L-citrullyl-[protein] + NH4(+) => H2O + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53728", "l": "H2O + N-acetyl-D-muramate 6-phosphate = N-acetyl-D-muramate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.105", "l": "\"N-acetyl-D-muramate 6-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30310", "l": "7-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71799", "l": "Ca(2+)(in) + H(+)(out) = Ca(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48674", "l": "20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10077", "l": "H2O + lactose => beta-D-galactose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70176", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate => alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205262", "l": "Direct recruitment of PI3K to p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39903", "l": "isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}, {"i": "EC:2.5.1.119", "l": "\"beta-(isoxazolin-5-on-4-yl)-L-alanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37575", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59722", "l": "D-maltohexaonate + H(+) => D-maltohexaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003747", "l": "translation release factor activity", "d": ["Involved in catalyzing the release of a nascent polypeptide chain from a ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004947", "l": "bradykinin receptor activity", "d": ["Combining with bradykinin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60819", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 <=> CO2 + gibberellin A14 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159259", "l": "MMAA:MUT binds AdoCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73665", "l": "CoA + H(+) + piperyline => (E,E)-piperoyl-CoA + pyrrolidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0031841", "l": "neuropeptide Y receptor binding", "d": ["Binding to a neuropeptide Y receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63699", "l": "SN-38 + UDP-alpha-D-glucuronate <=> H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54854", "l": "H2O + NADP(+) + propyl butanoate => H(+) + heptan-4-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102566", "l": "1-acyl dihydroxyacetone phosphate reductase activity", "d": ["Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018766", "l": "RHOU binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60651", "l": "an N-(acyl)-sphingosylphosphoethanolamine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046510", "l": "UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity", "d": ["Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032395", "l": "MHC class II receptor activity", "d": ["Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247497", "l": "ERBB3 binds neuregulins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811427", "l": "COPI vesicle uncoating at the ER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10775", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O <=> D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66444", "l": "hexan-3-one + NADP(+) = (E)-4-hexen-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140701", "l": "3',3'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP)."], "t": []}, {"i": "RHEA:35647", "l": "ATP + GTP = 3',3'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103080", "l": "methylthiopropylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) = 3-(3'-methylthio)propylmalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111930", "l": "Adenylate cyclase produces cAMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63564", "l": "apelin-13 + H2O = apelin-12 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29482", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epicubenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57463", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73399", "l": "D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785768", "l": "MRN complex binds DNA double strand breaks (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67811", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36685", "l": "CoA + S-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74102", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62803", "l": "2 7-demethylsiderin + NADPH + O2 <=> 2 H2O + NADP(+) + orlandin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424476", "l": "Activation of RAC1 by VAV2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47365", "l": "a dodecanoate ester + H2O => an aliphatic alcohol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700120", "l": "PTN and MDK bind to PTPRZ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75471", "l": "thiamine diphosphate(out) = thiamine diphosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12666", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA => an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76658", "l": "3-methylbutanal + H2O + NAD(+) <=> 3-methylbutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70557", "l": "L-seryl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37551", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate = 2-oxoglutarate + D-kanosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:2.6.1.104", "l": "\"3-dehydro-glucose-6-phosphate--glutamate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55326", "l": "11-cis-retinyl hexadecanoate + CoA => 11-cis-retinol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430183", "l": "NCK binds PAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59065", "l": "demethylluteothin + S-adenosyl-L-methionine => luteothin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52586", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => chenodeoxycholoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0017150", "l": "tRNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13526", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204773", "l": "Interaction of Tie2 and Grb7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55143", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11365", "l": "ATP + H2O + pyruvate => AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610720", "l": "PKA phosphorylates GLI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481044", "l": "Surface deployment of platelet alpha granule membrane components (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27710", "l": "ATP + guanosine = ADP + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430347", "l": "MigFilin associates with Filamin and F-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21456", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.68", "l": "\"(S)-canadine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56360", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 = 13-dihydrocarminomycin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857336", "l": "CEBPB homodimerization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72940", "l": "2 Na(+)(out) + propanoate(out) => 2 Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167429", "l": "The receptor:G-protein complex  binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57692", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36279", "l": "H(+) + NADH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102085", "l": "N-(4-aminobenzoyl)-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP = H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29725", "l": "glyoxylate(out) => glyoxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418858", "l": "RhoGTPase GEF's recruited to DCC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250892", "l": "botF LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74647", "l": "GTP + N-acetyl-D-glucosamine = GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71466", "l": "H2O + substance P <=> Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701903", "l": "ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75465", "l": "choline(in) + n H(+)(out) => choline(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71685", "l": "2 H(+)(in) + L-aspartyl-glycine(in) => 2 H(+)(out) + L-aspartyl-glycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102577", "l": "3-oxo-palmitate decarboxylase activity", "d": ["Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62499", "l": "ATP + H(+) + L-arginine <=> diphosphate + L-arginyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005093", "l": "Rab GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44907", "l": "alpha-D-glucose 6-phosphate + H2O <=> alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.325", "l": "\"juvenile hormone-III synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45051", "l": "acetamide + H2O <=> acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26174", "l": "CoA + H(+) + mycothiol => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59223", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27713", "l": "ATP + guanosine <=> ADP + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005010", "l": "insulin-like growth factor receptor activity", "d": ["Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186741", "l": "SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23287", "l": "isopentenyl diphosphate <=> dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635609", "l": "Rv3655c binds RNF213 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28530", "l": "H2O + XMP = phosphate + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71647", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.74", "l": "\"medium-chain-enoyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19311", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44400", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14048", "l": "1-carboxyvinyl carboxyphosphonate + H(+) <=> 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443439", "l": "c-Src binds Raf1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25747", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043894", "l": "acetyl-CoA synthetase acetyltransferase activity", "d": ["Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050579", "l": "vellosimine dehydrogenase activity", "d": ["Catalysis of the reaction: 10-deoxysarpagine + NADP+ = H+ + NADPH + vellosimine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32525", "l": "beta-D-glucose 1-phosphate + D-glucose => nigerose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23826", "l": "2,3-dihydroxybenzoate + H(+) + NADH => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734713", "l": "ORC6 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448741", "l": "IL22RA2 binds IL22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9710959", "l": "p-STAT1 dimer binds KPNA1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71540", "l": "H(+)(out) + 2 nitrate(out) => H(+)(in) + 2 nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72722", "l": "eIF2 activation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987214", "l": "p-STAT3 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.48", "l": "\"cerevisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839080", "l": "Activated cytosolic FGFR1 fusions bind PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950504", "l": "IL27 binds CRLF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52602", "l": "CoA + H(+) + N-propanoyl-L-methioninate => L-methionine + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37929", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389350", "l": "Activation of Cdc42 by pVav1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14627", "l": "[(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n) => [(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77586", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47396", "l": "H2O + octadecanoate ester = an aliphatic alcohol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33014", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43177", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51748", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A = 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47981", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56103", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50242", "l": "n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O => [hyaluronan](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72862", "l": "3',3',3'-c-tri-AMP + H2O <=> A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419351", "l": "PAF receptor binds platelet activating factor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428909", "l": "Activated TP receptor binds G-protein  G13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102460", "l": "kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166869", "l": "TRAF6 binds MEKK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55188", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide = 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70298", "l": "2-oxoglutarate + 3-sulfino-L-alanine <=> 3-sulfinopyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74106", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64851", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA <=> (3Z)-hex-3-en-1-yl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23256", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.10", "l": "\"adenosylcobyric acid synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75355", "l": "H2O + L-mimosine = 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.3.3.8", "l": "\"mimosinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53316", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.348", "l": "\"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26002", "l": "D-arabinitol 1-phosphate + NAD(+) = D-xylulose 5-phosphate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.301", "l": "\"D-arabitol-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68522", "l": "beta-acoradiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615554", "l": "MIR137 gene expression is inhibited by MECP2 and SOX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036199", "l": "cholest-4-en-3-one 26-monooxygenase activity", "d": ["Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70467", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12754", "l": "glycerol + NADP(+) => dihydroxyacetone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.266", "l": "\"dTDP-4-dehydro-6-deoxyglucose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30353", "l": "5-hydroxypyrrole-2-carboxylate + H2O + NAD(+) => H(+) + NADH + O2 + pyrrole-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58781", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine => a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712187", "l": "GNAL:GTP (G alpha-olf) binds ADCY3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183052", "l": "CBL binds to GRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64461", "l": "acetyl phosphate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30150", "l": "FADH2 + NAD(+) <=> FAD + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63424", "l": "(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.68", "l": "\"2-phospho-L-lactate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023028", "l": "MHC class I protein binding, via lateral surface", "d": ["Binding to a major histocompatibility complex class I molecules via the lateral surface."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60174", "l": "(2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16199", "l": "acetoacetyl-CoA + H(+) + NADPH => (3S)-3-hydroxybutanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20982", "l": "2 biliverdin IXalpha + 2 H2O => 2 bilirubin IXalpha + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70891", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) = L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14007", "l": "2-oxobutanoate + L-cysteine + NH4(+) => H2O + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38597", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61179", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14323", "l": "H(+) + morphinone + NADPH => morphine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25357", "l": "2,6,10,14-tetramethylpentadecanal + formyl-CoA => 2-hydroxyphytanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35363", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH = isopentadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73081", "l": "S-adenosyl-L-homocysteine + scutellarein 7-methyl ether => S-adenosyl-L-methionine + scutellarein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205262", "l": "Direct recruitment of PI3K to p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52960", "l": "hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66596", "l": "O2 + 2 tyramine = 2 dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036308", "l": "ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186780", "l": "PI3-kinase binds to the active receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27459", "l": "3,5-diiodo-L-tyrosine + H(+) + NADPH => 3-iodo-L-tyrosine + iodide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47884", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75878", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653974", "l": "Ragulator binds Rag dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11394", "l": "1D-myo-inositol 1,3,4-trisphosphate + phosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72922", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42772", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.179", "l": "\"16S rRNA (guanine(1405)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65841", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) => ATP(in) + Mg(2+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66767", "l": "ATP + folate(in) + H2O <=> ADP + folate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52349", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.3", "l": "\"triacylglycerol lipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50800", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297354", "l": "Acrosin Cleavage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63604", "l": "[Pyr1]apelin-13 + H2O = [Pyr1]apelin-12 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45598", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015440", "l": "ABC-type peptide transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75501", "l": "cholate(in) + n H(+)(in) => cholate(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981713", "l": "C4b binds to cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683831", "l": "CCDC59 binds TTF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22139", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 <=> chlorophyllide b + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50270", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093327", "l": "EPHA binds TIAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.32", "l": "\"palmitoyl-CoA 14-(E/Z)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66063", "l": "2-oxohexanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56227", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33872", "l": "(S)-2-ureidoglycine + H2O => glyoxylate + NH4(+) + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806610", "l": "Keratin filament formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46813", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45994", "l": "(2E)-decenoyl-CoA + H2O => (3R)-3-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806394", "l": "TP53 and AP-1 stimulate MSH2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61617", "l": "H(+) + L-proline betaine + NADH + O2 => formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12942", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49181", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine => a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69373", "l": "2-hydroxyhexanoate + O2 => 2-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034543", "l": "5-aminosalicylate dioxygenase activity", "d": ["Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19370", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76674", "l": "furfural + H2O + NADP(+) <=> 2-furoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879930", "l": "STAT5 is recruited by JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71167", "l": "glycine(out) + H(+)(in) + Na(+)(out) = glycine(in) + H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71013", "l": "L-isoleucine(out) + L-phenylalanine(in) => L-isoleucine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70747", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34990", "l": "(S)-lactate(in) <=> (S)-lactate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015111", "l": "Factor Xa inhibitors binds Xa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77457", "l": "(2R)-2-hydroxy-2-(thiophen-2-yl)acetonitrile => formylthiophene + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9640195", "l": "RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67384", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72666", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16729", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74173", "l": "an alcohol + CO2 + methylamine => an N-methyl carbamate ester + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046969", "l": "NAD-dependent histone H3K9 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein."], "t": []}, {"i": "REACT:R-HSA-9604829", "l": "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.142", "l": "\"glycoprotein O-fatty-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033783", "l": "25-hydroxycholesterol 7alpha-hydroxylase activity", "d": ["Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875443", "l": "USP8 deubiquitinates LRIG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18563", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004168", "l": "dolichol kinase activity", "d": ["Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45035", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75545", "l": "(2E)-decenoyl-[ACP] + glycine + H2O => (3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32605", "l": "(6E)-8-oxogeraniol + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22701", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53802", "l": "lithocholate + ursodeoxycholoyl-CoA => lithocholoyl-CoA + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421453", "l": "Mitochondrial uptake and processing of ALAS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797100", "l": "CCNK binds CDK13 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32664", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine => 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814088", "l": "SYS1 binds AcM-ARFRP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37815", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975170", "l": "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001066", "l": "amylopectin binding", "d": ["Binding to amylopectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53125", "l": "all-trans-lycopene => delta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43341", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016169", "l": "bacteriochlorophyll c binding", "d": ["Binding to bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080100", "l": "L-glutamine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807872", "l": "Active ARF recruits coatomer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617867", "l": "HOXB4 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051730", "l": "GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139941", "l": "Binding of IP3 to IP3 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.196", "l": "\"limit dextrin alpha-1,6-maltotetraose-hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032440", "l": "2-alkenal reductase [NAD(P)+] activity", "d": ["Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+."], "t": []}, {"i": "EC:1.3.1.74", "l": "\"2-alkenal reductase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71303", "l": "RPE dimers isomerise RU5P to XY5P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64795", "l": "L-lysine + NADP(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41717", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28466", "l": "pyridoxamine(in) = pyridoxamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45681", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77094", "l": "ATP + isochorismate + L-glutamate <=> AMP + diphosphate + H(+) + isochorismoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65800", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O = a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0106130", "l": "purine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71619", "l": "(S)-malate(in) + 2 thiosulfate(out) = (S)-malate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31162", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69756", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19652", "l": "ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73269", "l": "H(+)(in) + L-methionine(out) => H(+)(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13559", "l": "ADP + glutathione + H(+) + phosphate => ATP + gamma-L-glutamyl-L-cysteine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32080", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659820", "l": "RB1 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71336", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) => chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19300", "l": "ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111915", "l": "CAMK4 autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73626", "l": "CTP(out) + GDP(in) <=> CTP(in) + GDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15489", "l": "adenosine + H2O + 2 O2 = 9-riburonosyladenine + H(+) + 2 H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.39", "l": "\"nucleoside oxidase (H2O2-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391372", "l": "GNRHR binds GNRH1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166041", "l": "Transfer of LPS onto TLR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31334", "l": "ATP + H(+) + molybdopterin <=> adenylyl-molybdopterin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41593", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809309", "l": "MTMR6 binds MTMR9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69084", "l": "acrolein + H2O + NAD(+) = acrylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419011", "l": "Transhomodimerization of Nectins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17658", "l": "an acyl-CoA + dihydroxyacetone phosphate => a 1-acylglycerone 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70546", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68864", "l": "H2O + isomaltose = alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12161", "l": "2-deoxy-D-gluconate + NAD(+) => 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031839", "l": "type 1 neuromedin U receptor binding", "d": ["Binding to a type 1 neuromedin U receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730835", "l": "Autophosphorylation of PKC-theta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32837", "l": "4-(trimethylamino)butanoate(out) => 4-(trimethylamino)butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015361", "l": "low-affinity sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}, {"i": "REACT:R-HSA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71108", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) => L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21021", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate => chorismate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667563", "l": "AVPR2 bind desmopressin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.87", "l": "\"2-hydroxyisoflavanone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40540", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798743", "l": "Exocytosis of secretory granule membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008713", "l": "ADP-heptose-lipopolysaccharide heptosyltransferase activity", "d": ["Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73792", "l": "dimethylallyl diphosphate + neoechinulin A => diphosphate + variecolorin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14434", "l": "a tRNA precursor + ATP + 2 CTP => a tRNA with a 3' CCA end + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39806", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71729", "l": "citrate(in) + fumarate(out) => citrate(out) + fumarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76190", "l": "an L-amino acid tripeptide(out) + 2 H(+)(out) <=> an L-amino acid tripeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804383", "l": "PRMT5 methylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59288", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O = D-glucose + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71228", "l": "2 Na(+)(out) + selenocyanate(out) => 2 Na(+)(in) + selenocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13748", "l": "ascopyrone M <=> microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43255", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40874", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888589", "l": "Release of GABA at the synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50606", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] => acetyl-CoA + N-terminal L-methionyl-[transmembrane protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11099", "l": "NADP(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45146", "l": "acetaldehyde + CO2 + CoA + methanethiol => 3-(methylsulfanyl)acryloyl-CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64641", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => lactose + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450770", "l": "MWH binds to RHO1:GTP and is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44734", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030736", "l": "phenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55958", "l": "(12R)-hydroxy-(9Z)-octadecenoate + A + H2O => (9Z)-octadecenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23495", "l": "UDP-alpha-D-glucosamine <=> UDP-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64497", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] => 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112429", "l": "Formation of FACT complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62163", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate <=> N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18675", "l": "ADP + H(+) + O-phospho-L-seryl-[receptor-protein] => ATP + L-seryl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75633", "l": "plasmodiophorol C => H2O + plasmodiophorol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649108", "l": "HTR3A pentamer binds 5HT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417898", "l": "P2Y4 receptor can bind to UTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76448", "l": "ATP + L-aspartate + L-methionine => ADP + H(+) + L-aspartyl-L-methionine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59821", "l": "2 ATP => adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39166", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22020", "l": "ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.3.2.5", "l": "\"ABC-type molybdate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74685", "l": "4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine => 2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033929", "l": "blood-group-substance endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67453", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O => 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33489", "l": "CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.50", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25076", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.25", "l": "\"methane monooxygenase (soluble)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19916", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68319", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56546", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849428", "l": "PTPN1 binds PTK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29992", "l": "H(+)(in) + L-lyxopyranose(in) => H(+)(out) + L-lyxopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13859", "l": "a dolichyl phosphate + D-glucose + H(+) => a dolichyl beta-D-glucosyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190258", "l": "FGFR2c binds to FGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000247", "l": "C-8 sterol isomerase activity", "d": ["Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611277", "l": "P2RY12 binds P2RY12 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69130", "l": "4-methyl-2-oxopentanoate + glycine => glyoxylate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043812", "l": "phosphatidylinositol-4-phosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol-4-phosphate + H2O = phosphatidyl-1D-myo-inositol + phosphate."], "t": []}, {"i": "RHEA:55652", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700168", "l": "Active ALK phosphorylates IRS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35180", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA => 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51373", "l": "(9Z)-hexadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112125", "l": "Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467794", "l": "Resolution of sister chromatids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983424", "l": "Budding of COPII coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050608", "l": "vanillin dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + vanillin = 2 H+ + NADH + vanillate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19967", "l": "acrylate + dimethyl sulfide + H(+) => S,S-dimethyl-beta-propiothetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43508", "l": "2,5-diformylfuran + H2O = 2-(dihydroxymethyl)-5-formylfuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41192", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804996", "l": "p14ARF sequesters MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62239", "l": "a cytidine(6-4)cytidine in DNA <=> a cytidine dimer in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34937", "l": "diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71186", "l": "L-kynurenine(out) + L-tryptophan(in) <=> L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797553", "l": "Protein 4.1 binds CASK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55824", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d = a bacteriochlorophyllide f + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35240", "l": "tetracycline(in) => tetracycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17113", "l": "H2O + L-serine-phosphoethanolamine = H(+) + L-serine + phosphoethanolamine", "d": [], "t": []}, {"i": "EC:3.1.4.13", "l": "\"serine-ethanolaminephosphate phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14603", "l": "5-aminopentanamide + CO2 + H2O => L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369028", "l": "ABCAs mediate lipid efflux (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77491", "l": "3,3-dimethylbutan-2-one + hydrogen cyanide = (2S)-2-hydroxy-2-methyl-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2473186", "l": "FSTL3 binds Activin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39047", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14813", "l": "L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam", "d": [], "t": []}, {"i": "EC:5.1.1.15", "l": "\"2-aminohexano-6-lactam racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74416", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106080", "l": "GATOR1 complex binding", "d": ["Binding to a GATOR1 complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15404", "l": "a dolichyl phosphate + UDP-alpha-D-glucose <=> a dolichyl beta-D-glucosyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008425", "l": "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44802", "l": "2-demethylmenaquinol-6 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851908", "l": "Activated MET binds GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17857", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58434", "l": "(E)-4-oxonon-2-enal + H(+) + NADPH => (E)-4-oxonon-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106335", "l": "tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity", "d": ["Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63379", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849900", "l": "SALMs1-3 bind each other in cis interactions (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632182", "l": "PRMT1 methylates ESRs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18620", "l": "ATP + oxaloacetate <=> ADP + CO2 + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322431", "l": "XIAP binds TLE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944263", "l": "Association of procollagen type II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710354", "l": "GSDME (1-270) binds cardiolipin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761344", "l": "USP18 binds IKBKG within IKK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34243", "l": "GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide", "d": [], "t": []}, {"i": "EC:2.7.7.77", "l": "\"molybdenum cofactor guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876484", "l": "NPC2 transfers CHOL to NPC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848077", "l": "PTK6 phosphorylates STAP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0015205", "l": "nucleobase transmembrane transporter activity", "d": ["Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632672", "l": "ADRBK1 phosphorylates SMO dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163320", "l": "Association of mTERF with the termination sequence (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17838", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O => 2-carboxy-D-arabinitol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110363", "l": "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34516", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27759", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640167", "l": "RRAGA,B exchanges GDP for GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10944", "l": "H2O + psi-UMP = phosphate + pseudouridine", "d": [], "t": []}, {"i": "EC:3.1.3.96", "l": "\"pseudouridine 5'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60276", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.355", "l": "\"[histone H3]-lysine(9) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37191", "l": "2',3'-cyclophospho-AMP + H2O = adenosine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30345", "l": "FADH2 + fumarate => FAD + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43490", "l": "chlorophyll b + H(+) + NADH => 7(1)-hydroxychlorophyll a + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83788", "l": "Binding of TFIIIC to Type 2 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804099", "l": "HMGB1 binds LTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31390", "l": "(S)-2,3-epoxysqualene <=> alpha-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0045183", "l": "translation factor activity, non-nucleic acid binding", "d": ["A translation regulator activity that does not involve binding to nucleic acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917693", "l": "ESCRT Disassembly (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40615", "l": "H2O + tridecanoylglycerol = 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29245", "l": "menaquinol-8 + NAD(+) => H(+) + menaquinone-8 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9639286", "l": "RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609921", "l": "SGTA binds Tail-anchored protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033704", "l": "3beta-hydroxy-5alpha-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnane-3,20-dione + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199910", "l": "MSK1 activates ATF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51976", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004921", "l": "interleukin-11 receptor activity", "d": ["Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34944", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) => arbutin 6-phosphate(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26518", "l": "3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013143", "l": "RAC1 GEFs activate RAC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58534", "l": "akuammicine + formate + H(+) => 15alpha-stemmadenine intermediate I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730902", "l": "Oligomerization of p-CARMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212222", "l": "PRC2 recruits DNA methyltransferases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47101", "l": "choloyl-CoA + taurine => CoA + H(+) + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56765", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 => 12-epi-fischerindole G + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671876", "l": "Phosphorylated STAT5 Dissociates from Leptin Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66284", "l": "tomatidine + UDP-alpha-D-glucose = H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008917", "l": "lipopolysaccharide N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102817", "l": "caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA = gentiodelphin + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848606", "l": "PTK6 phosphorylates PXN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380316", "l": "Association of NuMA with microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35532", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 => albonoursin + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38783", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933526", "l": "Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674018", "l": "BRAP binds RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46344", "l": "propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35864", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44035", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O <=> 9,10-dihydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047077", "l": "Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65982", "l": "tachysterol 3 => hnu + previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853496", "l": "SCF:FBXL7 binds AURKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48161", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688797", "l": "ATXN3 family cleave Ub chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68417", "l": "cis-(homo)2aconitate + H2O => (2R,3S)-iso(homo)2citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70719", "l": "L-alanine(in) = L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12518", "l": "(+)-(R)-germacrene A + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14394", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15333", "l": "(S)-ureidoglycolate + NADP(+) = H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67065", "l": "AH2 + asnovolin K => A + asnovolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001864", "l": "pentraxin binding", "d": ["Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45353", "l": "9,10-epoxyoctadecanoate + H2O => 9,10-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40479", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20297", "l": "an anilide + H2O = a carboxylate + aniline + H(+)", "d": [], "t": []}, {"i": "EC:3.5.1.13", "l": "\"aryl-acylamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005176", "l": "ErbB-2 class receptor binding", "d": ["Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.55", "l": "\"caldesmon-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75172", "l": "Formation of RAD50:MRE11 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50215", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483219", "l": "PC is exchanged with PI by PITPNB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59526", "l": "9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein] => 9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204485", "l": "Basigin binds CyPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0051010", "l": "microtubule plus-end binding", "d": ["Binding to the plus end of a microtubule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14069", "l": "D-fructose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.124", "l": "\"fructose 5-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72143", "l": "AH2 + GTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.15", "l": "\"endo-polygalacturonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24304", "l": "glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}, {"i": "EC:1.4.4.2", "l": "\"glycine dehydrogenase (aminomethyl-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0001098", "l": "basal transcription machinery binding", "d": ["Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216988", "l": "Monoubiquitination of PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75338", "l": "bromide(in) + chloride(out) <=> bromide(out) + chloride(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21762", "l": "(3R)-3-hydroxybutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27733", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) <=> beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40371", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP = 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.181", "l": "\"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60965", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71890", "l": "GTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42963", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] <=> NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41272", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28360", "l": "(2E)-tetradecenoyl-CoA + FADH2 => FAD + H(+) + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1834951", "l": "IFI16 binds cytosolic dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813626", "l": "LEAP2 binds bacteria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371591", "l": "Trimerization of cytosolic HSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71034", "l": "L-cysteine(in) + L-phenylalanine(out) <=> L-cysteine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23846", "l": "ADP + D-sedoheptulose 7-phosphate + H(+) => ATP + sedoheptulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35316", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39490", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.17", "l": "\"non-stereospecific dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102656", "l": "1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23808", "l": "(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.117", "l": "\"(S)-scoulerine 9-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49970", "l": "17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37680", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59893", "l": "L-2-amino-4-chloropent-4-enoate => chloride + H(+) + L-propargylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180630", "l": "Association of APOBEC3G with Gag (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27603", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate => di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19448", "l": "2,3-dihydroxyindole + O2 <=> anthranilate + CO2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65403", "l": "butan-1-ol + butanoyl-CoA <=> butyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032557", "l": "pyrimidine ribonucleotide binding", "d": ["Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0120016", "l": "sphingolipid transfer activity", "d": ["Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446391", "l": "Formation of the PINCH-ILK-parvin complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22640", "l": "NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.102", "l": "\"3-dehydrosphinganine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419087", "l": "LIM kinase phosphorylation by ROCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47894", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75891", "l": "Abortive Initiation After Second Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688786", "l": "ATXN3 binds RAD23 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42145", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25450", "l": "(+)-guaia-6,9-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176175", "l": "Stalling of DNA replication fork and RPA binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483186", "l": "PC is converted to PS by PTDSS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47407", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64256", "l": "dodecanoyl-CoA + glycine = CoA + H(+) + N-dodecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.-", "l": "\"In linear amides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66200", "l": "O2 + pentanoyl-CoA = (2E)-pentenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45498", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72636", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68688", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) = 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31400", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) => all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35392", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49464", "l": "2,6-dihydroxybenzoate + H(+) = CO2 + resorcinol", "d": [], "t": []}, {"i": "EC:4.1.1.103", "l": "\"gamma-resorcylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37750", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine <=> 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70229", "l": "(E)-2-benzylidenesuccinyl-CoA + H2O => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193653", "l": "NGF homodimer binds to p75NTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451309", "l": "Edited Kainate Receptor binds glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202437", "l": "Phosphorylation of CARMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396401", "l": "NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76791", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166538", "l": "The bound receptor dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174119", "l": "Free APC/C phosphorylated by Plk1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018804", "l": "RAC3 GEFs activate RAC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655193", "l": "KIAA0101 double monoubiquitination (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028815", "l": "p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70545", "l": "3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42108", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46725", "l": "(2S)-2-methyltetradecanoyl-CoA => (2R)-2-methyltetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42949", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140989", "l": "7-deoxyloganate 7-hydroxylase activity", "d": ["Catalysis of the reaction: 7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganate + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70803", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111883", "l": "Hydrolysis of phosphatidylcholine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48455", "l": "a ganglioside GA2 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24368", "l": "L-ornithine = L-proline + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.12", "l": "\"ornithine cyclodeaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57777", "l": "2-chloro-6-nitrotoluene + NADH + O2 => 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66907", "l": "A + cannabinerolate <=> AH2 + cannabichromenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36725", "l": "2-phenylacetaldehyde + AH2 + NH4(+) => 2-phenylethylamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445064", "l": "Activation of Rac1 by VAV2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45805", "l": "ATP + hydroxylamine + L-glutamate => ADP + L-glutamine hydroxamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619756", "l": "NR1H2 binds ABCA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.31", "l": "\"scytalidopepsin A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102915", "l": "piperitol synthase activity", "d": ["Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 = (+)-piperitol + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30176", "l": "15-cis-phytoene + 2 plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14786", "l": "RNA(n) + UTP => diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36670", "l": "(15Z)-tetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66082", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209114", "l": "Translation of p16INK4A mRNA is inhibited by miR-24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32277", "l": "3-amino-2-oxopropyl phosphate + CO2 + NADH => 4-(phosphooxy)-L-threonine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66483", "l": "gypsogenin + UDP-alpha-D-glucose <=> gypsogenin 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858500", "l": "CLEC10A binds Tn-MUC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25499", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429157", "l": "ABCC4 accumulation of dense granule contents (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30152", "l": "FADH2 + NADP(+) => FAD + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40341", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66264", "l": "ATP + H(+) + nonanoate = diphosphate + nonanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097690", "l": "iron ion transmembrane transporter inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30390", "l": "GDP-alpha-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11153", "l": "5-pyridoxate + NADPH + O2 => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48403", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23717", "l": "(3Z)-dodecenoyl-CoA => (2E)-dodecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36114", "l": "gibberellin A1 + S-adenosyl-L-methionine <=> O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36936", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55428", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.60", "l": "\"ferruginol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044682", "l": "GTP cyclohydrolase IV activity", "d": ["Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70053", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate => 2-oxoadipate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40469", "l": "(9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45195", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69105", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine => H2O + kynurenate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29555", "l": "H2O + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59388", "l": "a fatty acid ester + H2O = a fatty acid + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362416", "l": "Frataxin binds iron (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38383", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:0120013", "l": "lipid transfer activity", "d": ["Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134800", "l": "STING dimerization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45298", "l": "a sphingoid base + H(+) + phosphocholine => a sphingosylphosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76122", "l": "a dicarboxylate(in) + prostaglandin F2alpha(out) <=> a dicarboxylate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179417", "l": "Multiubiquitination of Nek2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67418", "l": "(1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37412", "l": "aklavinone + NADP(+) => aklaviketone + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210294", "l": "Interaction of PECAM-1 and SHP-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852362", "l": "GTSE1 binds CDKN1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41221", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16406", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) => benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40189", "l": "(3R)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090722", "l": "receptor-receptor interaction", "d": ["The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51903", "l": "H2O + N(1)-acetylspermidine <=> acetate + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805981", "l": "HMGB1 release from cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63667", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928619", "l": "PAK1 binds RAC1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33391", "l": "C20 sphinganine 1-phosphate + H2O = C20 sphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38002", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine <=> H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21984", "l": "3'-phosphoadenylyl sulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.6", "l": "\"choline sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805103", "l": "AURKA phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983147", "l": "Release of E3 from polyubiquitinated substrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052630", "l": "UDP-N-acetylgalactosamine diphosphorylase activity", "d": ["Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58618", "l": "glyoxylate + octanamide => N-octanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51196", "l": "chloride(out) + Na(+)(out) + serotonin(out) = chloride(in) + Na(+)(in) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995334", "l": "COX15 transforms heme O to heme A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13248", "l": "D-threo-isocitrate <=> glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736992", "l": "p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70099", "l": "H(+) + o-quinone methide + peniphenone D = penilactone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15477", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.32", "l": "\"scymnol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64632", "l": "acetyl-CoA + butan-1-ol = butyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706330", "l": "Active FLT3 binds to SOCS6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675431", "l": "PP2A dephosphorylates RAF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204824", "l": "Interaction of Tie2 and Ang4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016520", "l": "growth hormone-releasing hormone receptor activity", "d": ["Combining with growth hormone-releasing hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64273", "l": "benzylamine + pyruvate => benzaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.138", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019135", "l": "deoxyhypusine monooxygenase activity", "d": ["Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928620", "l": "PAK1 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225950", "l": "Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17015", "l": "3-phosphonopyruvate => H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042086", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730899", "l": "Oligomerization of BCL10 and MALT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62142", "l": "dTDP + GDP => dTMP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090554", "l": "phosphatidylcholine floppase activity", "d": ["Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}, {"i": "RHEA:38583", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928591", "l": "EPH:EFN tetramers oligomerise (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44758", "l": "6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30893", "l": "acetate + H(+) + S-sulfo-L-cysteine => O-acetyl-L-serine + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9617595", "l": "SGTA binds mislocalized membrane protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000341", "l": "RNA trimethylguanosine cap binding", "d": ["Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23014", "l": "a fatty acid methyl ester + S-adenosyl-L-homocysteine => a fatty acid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183122", "l": "Factor D cleaves C3b-bound Factor B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48146", "l": "ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093329", "l": "EFNBs bind SDCBP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443418", "l": "GP1b signaling involves c-Src (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727819", "l": "TAK1 phosphorylates MKK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67686", "l": "a long-chain fatty acid(out) + ADP + H(+) + phosphate => a long-chain fatty acid(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72095", "l": "Internal Methylation of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102083", "l": "7,8-dihydromonapterin aldolase activity", "d": ["Catalysis of the reaction: 7,8-dihydromonapterin = glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65992", "l": "calciol + hnu = 5,6-trans-vitamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27335", "l": "2,5-dihydroxypyridine + CO2 + H2O + NAD(+) => 6-hydroxynicotinate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654625", "l": "Activated FGFR3 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158313", "l": "factor XII -> factor XIIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38809", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660660", "l": "p300 acetylates RELA subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213017", "l": "Auto-ubiquitination of TRAF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683735", "l": "mRNA9 is translated to Nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794346", "l": "NRXNs bind NLGNs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24094", "l": "2 (2S)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16445", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68833", "l": "(2Z,6Z)-farnesyl diphosphate + H2O => (6Z)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467466", "l": "ABCA4 mediates atRAL transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36592", "l": "(S)-2-chloropropanoate + NADP(+) => 2-chloroacrylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73956", "l": "3,4-dihydroxystyrene + H(+) + NADH => 4-ethylcatechol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2201341", "l": "Endocytosis of TRAM (TICAM2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443831", "l": "14-3-3-zeta binds Raf1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450802", "l": "FZ and VANG bind to STAN homodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71426", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28242", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] = 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047608", "l": "acetylindoxyl oxidase activity", "d": ["Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33372", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951727", "l": "cAMP binds PKA tetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52286", "l": "11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44960", "l": "(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626046", "l": "p-GFAP binds EEF1A1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70473", "l": "a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.110", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.136", "l": "\"2-acylphloroglucinol 4-prenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10373", "l": "CoA + NAD(+) + phenylglyoxylate => benzoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228811", "l": "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875451", "l": "MET phosphorylates CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106008", "l": "2-oxoglutaramate amidase activity", "d": ["Catalysis of the reaction: 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59548", "l": "N,N',N''-triacetylchitotriose + O2 = H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43457", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA => (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102059", "l": "2-cis,6-cis-farnesyl pyrophosphate synthase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047980", "l": "hippurate hydrolase activity", "d": ["Catalysis of the reaction: N-benzoylglycine + H2O = benzoate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801666", "l": "PLK2 phosphorylates CENPJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067659", "l": "Assembly of hexameric IL-6 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59257", "l": "Fe(III)-enterobactin + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62222", "l": "neopatulin => phyllostine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30023", "l": "L-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-901047", "l": "Binding of ERp57 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20227", "l": "(E)-ferulate + H(+) + S-adenosyl-L-homocysteine => (E)-caffeate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77535", "l": "H2O + L-methionyl-tRNA(Leu) = H(+) + L-methionine + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141341", "l": "SMOX-3 oxidises SPN to SPM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24413", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) => 4-formylbenzenesulfonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66822", "l": "ADP + H(+) + Mn(2+)(out) + phosphate => ATP + H2O + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67587", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189467", "l": "Cytosolic COPRO3 translocates to mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698041", "l": "p-STAT5 binds the CDKN1A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604308", "l": "NICD4 traffics to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66388", "l": "ATP + H2O + prostaglandin E2(in) = ADP + H(+) + phosphate + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40305", "l": "(2E)-dodecenedioyl-CoA + AH2 => A + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33229", "l": "4-hydroxystyrene + CO2 => (E)-4-coumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71592", "l": "2-oxoglutarate(out) + malonate(in) => 2-oxoglutarate(in) + malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398040", "l": "Gbeta:gamma activation of PLC beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388832", "l": "PI3K binds CD28 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22332", "l": "(3R)-citramalate = 2-methylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018825", "l": "RHOT2 GEFs activate RHOT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1564169", "l": "Collagen type VIII degradation by MMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57855", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17941", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.99", "l": "\"2-methylisocitrate dehydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613497", "l": "Unwinding DNA for the nascent transcript (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12824", "l": "2-deoxy-D-ribose 5-phosphate <=> acetaldehyde + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27975", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) => 7-carboxy-7-deazaguanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046589", "l": "ribonuclease T1 activity", "d": ["Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12280", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.149", "l": "\"1-phosphatidylinositol-5-phosphate 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65162", "l": "CoA + hexan-2-yl benzoate => benzoyl-CoA + hexan-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225951", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18155", "l": "diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004645", "l": "1,4-alpha-oligoglucan phosphorylase activity", "d": ["Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58285", "l": "5,6-dihydrothymine + NADP(+) => H(+) + NADPH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73390", "l": "H(+)(in) + malonate(out) + phosphate(in) <=> H(+)(out) + malonate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030586", "l": "[methionine synthase] reductase activity", "d": ["Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050080", "l": "malonyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21093", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine => dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.286", "l": "\"isocitrate--homoisocitrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855232", "l": "RELN:VLDLR binds DAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061786", "l": "peptidoglycan stem peptide endopeptidase activity", "d": ["A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.14", "l": "\"asparagine--oxo-acid transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40264", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60741", "l": "(S)-(-)-citronellal + H2O + NADP(+) => (S)-(-)-citronellate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31363", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.5.1.40", "l": "\"8-hydroxy-5-deazaflavin:NADPH oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0097199", "l": "cysteine-type endopeptidase activity involved in apoptotic signaling pathway", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2129362", "l": "Fibrillin microfibril assembly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47608", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57594", "l": "(2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18830", "l": "4-phospho-D-erythronate + NAD(+) => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080124", "l": "pheophytinase activity", "d": ["Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41883", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH <=> dodecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72360", "l": "glutarate(in) + succinate(out) => glutarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985201", "l": "ABCE1 binds RNASEL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681294", "l": "IL6R binds IL6R inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052836", "l": "inositol 5-diphosphate pentakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23707", "l": "GTP + 4 H2O <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951966", "l": "EP300 acetylates RUNX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964773", "l": "OXGR1 binds 2OG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14853", "l": "4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": [], "t": []}, {"i": "EC:3.8.1.7", "l": "\"4-chlorobenzoyl-CoA dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47075", "l": "1-eicosanoylglycerol + H2O <=> eicosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28017", "l": "S-adenosyl-L-methionine + thiocyanate <=> methyl thiocyanate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862300", "l": "LYZ binds bacterial peptidoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32010", "l": "9alpha-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686430", "l": "MUS81 binds EME1, EME2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003860", "l": "3-hydroxyisobutyryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41075", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64391", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate <=> 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49234", "l": "D-mannose 6-phosphate(in) + L-histidyl-[protein] => D-mannose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59619", "l": "beta-alanyl-L-arginine + H2O <=> beta-alanine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429101", "l": "HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043758", "l": "acetate-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44151", "l": "L-lysine <=> D-beta-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22214", "l": "(2R,3S)-tartrate => (2R,3R)-tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176116", "l": "Recruitment and activation of Chk1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51605", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18476", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67438", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004936", "l": "alpha-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0019958", "l": "C-X-C chemokine binding", "d": ["Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53599", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296127", "l": "Activation of voltage gated Potassium channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70577", "l": "H(+) + UMP => 3',5'-cyclic UMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709179", "l": "DPP4 binds DPP4 inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45990", "l": "3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O => 3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956639", "l": "RUNX1 binds YAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74610", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) <=> UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60152", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamate + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604722", "l": "Activation of proMMP9 by proteases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050272", "l": "S-carboxymethylcysteine synthase activity", "d": ["Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350450", "l": "RHO1:GTP complex dissociates from RHOGEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56440", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38107", "l": "2-dehydro-3-deoxy-L-galactonate = L-glyceraldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.54", "l": "\"L-threo-3-deoxy-hexylosonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033983", "l": "diaminobutyrate decarboxylase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + H+ = 1,3-diaminopropane + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13037", "l": "ATP + H(+) + H2O = ITP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20275", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70982", "l": "Fumarate + H2O <=> (S)-Malate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45671", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35998", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018756", "l": "RHOH binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683888", "l": "LMCD1 binds GATA6, sequestering it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42457", "l": "4alpha-methylzymosterol => zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73218", "l": "sulfate(out) + thiosulfate(in) <=> sulfate(in) + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622667", "l": "BBC3 gene expression is stimulated by FOXO3,(FOXO1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43739", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32637", "l": "(6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18961", "l": "D-allose + L-lysyl-[protein] = H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41111", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427570", "l": "Group 3 - Selective Cl- transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877902", "l": "Activated AR binds RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12935", "l": "(S)-lactaldehyde + dihydroxyacetone phosphate => L-fuculose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043722", "l": "4-hydroxyphenylacetate decarboxylase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-cresol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75938", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine <=> 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65659", "l": "A + cholest-1,4-dien-3-one + H2O <=> 25-hydroxycholest-1,4-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31474", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57386", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA => (13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46863", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31403", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) = all-trans-4,4'-diaponeurosporene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38917", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15322", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53552", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678327", "l": "MIOX oxidises Ins to GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58662", "l": "a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30326", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72548", "l": "2-oxoglutarate(in) + taurocholate(out) => 2-oxoglutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47216", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10332", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.62", "l": "\"2-acylglycerophosphocholine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27952", "l": "L-phenylalanine(out) => L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47805", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40787", "l": "H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709883", "l": "BIL:ALB scavenges O2.- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29106", "l": "5 H(+)(in) + menaquinone-8 + NADH <=> 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76303", "l": "L-cystine(out) = L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976801", "l": "Complement factor I complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15713", "l": "a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D-galactoside + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.18", "l": "\"galactoside O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39357", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865491", "l": "RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66336", "l": "L-glutamate(out) = L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77265", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(out) => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15225", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose", "d": [], "t": []}, {"i": "EC:2.7.7.24", "l": "\"glucose-1-phosphate thymidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11217", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP => a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389954", "l": "Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004318", "l": "enoyl-[acyl-carrier-protein] reductase (NADH) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701485", "l": "Active ALK binds JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937792", "l": "RUNX3 binds SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19642", "l": "(E)-4-coumarate + ATP + CoA => (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.10", "l": "\"steroid C-25 hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851123", "l": "NPM1-ALK- and p-STAT3-dependent NOTCH gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14514", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine => ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66738", "l": "ADP + beta-citrylglutamate(out) + H(+) + phosphate => ATP + beta-citrylglutamate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63456", "l": "(2E,6E,10E)-geranylgeraniol + CTP = (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71874", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) <=> (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69497", "l": "decan-1-ol + O2 => decanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44442", "l": "a triacylglycerol + glycerol => a 1,3-diacylglycerol + a 1-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166538", "l": "The bound receptor dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854462", "l": "VLDLR binds VLDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404142", "l": "atROL binds RBP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636684", "l": "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202969", "l": "Caspase mediated cleavage of beta-catenin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59295", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O <=> D-galactose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49351", "l": "2,2-dihydroxyspirilloxanthin <=> 2-oxospirilloxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936631", "l": "sulfate uptake in the cytosol (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793958", "l": "Expression of STAT6-upregulated plasma membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786421", "l": "CHIA hydrolyses chitin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835443", "l": "STAT1,STAT3 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74612", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) => UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4084505", "l": "Laminins bind HSPG2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51890", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + NADH => 2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72467", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32063", "l": "8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31104", "l": "7,8-dihydrofolate + NADP(+) => folate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624951", "l": "TNPO1 binds KIF17 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071566", "l": "UFM1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64124", "l": "H2O + N-hexadecanoyl-L-phenylalanine = hexadecanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24109", "l": "H2O + N-methyl-2-oxoglutaramate => 2-oxoglutarate + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56665", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29702", "l": "dimethyl sulfoxide(in) <=> dimethyl sulfoxide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21439", "l": "[translation elongation factor 2] + ATP <=> [translation elongation factor 2]-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33770", "l": "a 3-hydroxy-fatty acyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684006", "l": "KPNA2 translocates NBN to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451309", "l": "Edited Kainate Receptor binds glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74539", "l": "creatinine(in) = creatinine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60381", "l": "L-dehydroascorbate(out) => L-dehydroascorbate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032315", "l": "oxo-DHAs translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209361", "l": "STAT92E binds to phosphorylated HOP and phosphorylated DOME (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25176", "l": "H2O + N(omega)-methyl-L-arginine <=> L-citrulline + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.-.-", "l": "\"Acting on ester bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163617", "l": "G alpha (s) activates adenylate cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50581", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46006", "l": "2-methylpropanoyl-CoA + H(+) + NADH => 2-methylpropanal + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57106", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2) => [(1->4)-alpha-D-galacturonosyl](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12930", "l": "2-oxoglutarate + acetyl-CoA + H2O => (2R)-homocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426155", "l": "SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24556", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.65", "l": "\"5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12052", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + trichodiene", "d": [], "t": []}, {"i": "EC:4.2.3.6", "l": "\"trichodiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10149", "l": "blasticidin S + H(+) + H2O => deaminohydroxyblasticidin S + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76494", "l": "(E)-ferulate + H2O <=> acetate + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803890", "l": "SFN dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22845", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29780", "l": "ATP + H2O + L-methionine(out) => ADP + H(+) + L-methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70494", "l": "GDP-beta-L-fucose + L-threonyl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655483", "l": "USP1 autocleavage (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047085", "l": "hydroxyphenylacetonitrile 2-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H+ + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030527", "l": "structural constituent of chromatin", "d": ["The action of a molecule that contributes to the structural integrity of chromatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69214", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39515", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47469", "l": "(2E,4E)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24161", "l": "D-galactose + O2 => D-galacto-hexodialdose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62007", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983147", "l": "Release of E3 from polyubiquitinated substrate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45409", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH => dodecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24692", "l": "(E)-coniferyl acetate + NADPH => acetate + eugenol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21143", "l": "ATP + inosine <=> ADP + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139905", "l": "Translocation of activated BAD protein to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986446", "l": "IL26 binds IL20RA:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.140", "l": "\"gluconate/galactonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83677", "l": "C4 deamination of cytidine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683429", "l": "nsp16 binds nsp10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018747", "l": "RHOQ GEFs activate RHOQ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42588", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299297", "l": "Activation of THIK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645535", "l": "ALPK1 phosphorylates TIFA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35606", "l": "beta-D-fructose 1-phosphate + H2O <=> D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028730", "l": "Activated NTRK2 binds FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692738", "l": "HRH2 binds HRH2 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36831", "l": "2 caldariellaquinol + n H(+)(in) + O2 = 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}, {"i": "EC:7.1.1.4", "l": "\"caldariellaquinol oxidase (H(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38117", "l": "1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42099", "l": "ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68128", "l": "a fatty acyl-CoA + phytol = a fatty acid phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55007", "l": "1-hydroxylimonen-2-one + NADPH + O2 <=> 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.17", "l": "\"corrinoid adenosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26395", "l": "2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => all-trans-zeaxanthin + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56729", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 => 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008839", "l": "4-hydroxy-tetrahydrodipicolinate reductase", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29813", "l": "ADP + H(+) + phosphate + thiamine(in) => ATP + H2O + thiamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.38", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74752", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol => holo-[polyketide synthase] + prefumagillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0099122", "l": "RNA polymerase II C-terminal domain binding", "d": ["Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75296", "l": "chloride(in) + sulfate(out) => chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781814", "l": "USP19 deubiquitinates RNF123 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12476", "l": "H2O + N-formyl-L-glutamate = formate + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.68", "l": "\"N-formylglutamate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12856", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> dhurrin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192325", "l": "25(R) THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13428", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O <=> a pyrimidine nucleobase + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655443", "l": "PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14492", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581488", "l": "SAG binds p-MII to form p-MII:SAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49865", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66486", "l": "16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP => 16alpha-hydroxygypsogenate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42194", "l": "(9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24726", "l": "N-demethylindolmycin + S-adenosyl-L-methionine = H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.328", "l": "\"N-demethylindolmycin N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821486", "l": "HCFC1 binds SET1A complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63474", "l": "ADP + all-trans-hexaprenyl phosphate + H(+) => all-trans-hexaprenol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33169", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol => 2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140857", "l": "histone H3T45 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22459", "l": "creatine + H2O <=> sarcosine + urea", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018730", "l": "glutaconate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10024", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102161", "l": "copal-8-ol diphosphate synthase activity", "d": ["Catalysis of the reaction: copal-8-ol diphosphate = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034525", "l": "1-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28637", "l": "(+)-5-epi-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52791", "l": "chlorophyll a + 2 H(+) <=> Mg(2+) + pheophytin a", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31149", "l": "3,4-dihydroxymandelaldehyde + H(+) + NADH => 3,4-dihydroxyphenylethyleneglycol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.8", "l": "\"benzoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196017", "l": "Dynamin is recruited to the gap junction plaque (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28066", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55280", "l": "13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47663", "l": "acetyl-CoA + L-methionine sulfoximine <=> CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44298", "l": "4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56792", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43666", "l": "2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36681", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH => dTDP-6-deoxy-alpha-D-allose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64213", "l": "an N-(fatty acyl)-L-isoleucine + H2O => a fatty acid + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57941", "l": "Fe-coproporphyrin III + H(+) + H2O2 => CO2 + 2 H2O + harderoheme III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44354", "l": "ADP + dapdiamide C + H(+) + phosphate => ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869694", "l": "oxPL binds CD14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9769235", "l": "MAGED1 binds NPAS4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9817575", "l": "ERO1B oxidizes P4HB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047526", "l": "2'-hydroxyisoflavone reductase activity", "d": ["Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008684", "l": "TBK1 phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24189", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) => 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20322", "l": "L-proline + NAD(+) => 1-pyrroline-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38006", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66001", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693540", "l": "MRN activates ATM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070226", "l": "sulfur:ferric ion oxidoreductase activity", "d": ["Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42998", "l": "(R)-cembrene A + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11708", "l": "H2O + IMP + NAD(+) = H(+) + NADH + XMP", "d": [], "t": []}, {"i": "EC:1.1.1.205", "l": "\"IMP dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57198", "l": "glycolate + H(+) + L-cysteinyl-[protein] => H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40481", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59766", "l": "CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102955", "l": "S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40250", "l": "H2O + rhodomycin D <=> 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73711", "l": "ATP(in) + UTP(out) = ATP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37823", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11661", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40907", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47781", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214405", "l": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65494", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50382", "l": "1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA => 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44044", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39732", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56009", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202127", "l": "eNOS synthesizes NO (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047588", "l": "5-aminopentanamidase activity", "d": ["Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849906", "l": "SALM1 binds NMDA receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034237", "l": "protein kinase A regulatory subunit binding", "d": ["Binding to one or both of the regulatory subunits of protein kinase A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15597", "l": "a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111915", "l": "CAMK4 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390663", "l": "ADRA2A,B,C bind ADR,NAd (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34630", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937807", "l": "SRC phosphorylates RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473594", "l": "Collagen type II degradation by MMP15 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13724", "l": "H2O + testololactone <=> H(+) + testolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018814", "l": "RHOT1 hydrolyzes GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77611", "l": "2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022879", "l": "protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449058", "l": "Interleukin-1 family are secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614544", "l": "Sulfite is oxidized to sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29456", "l": "D-serine(in) => D-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65121", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione => L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102811", "l": "geraniol 10-hydroxylase activity", "d": ["Catalysis of the reaction: geraniol + O2 + NADPH + H+ = (6E)-8-hydroxygeraniol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103098", "l": "CYP79F1 tetrahomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH = 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54540", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16705", "l": "17alpha-estradiol + NADP(+) = estrone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35081", "l": "doxorubicin(out) => doxorubicin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432909", "l": "Interaction of Plectin with Integrin beta 4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62804", "l": "2 7-demethylsiderin + NADPH + O2 = desertorin A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112434", "l": "Formation of DSIF complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49978", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine => butanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42594", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65248", "l": "AH2 + 5 H(+) + 5 malonyl-CoA = 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29494", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-4(14),5-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160931", "l": "Disassembly of tight junctions (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140696", "l": "factor V -> factor Va + factor V activation peptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37679", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50568", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22604", "l": "D-mannose = D-fructose", "d": [], "t": []}, {"i": "EC:5.3.1.7", "l": "\"mannose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035516", "l": "broad specificity oxidative DNA demethylase activity", "d": ["Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625424", "l": "The retrograde IFT train dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75259", "l": "isoorientin + O2 = 3'-dehydroisoorientin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56175", "l": "FMN + O2 <=> 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62773", "l": "N-acetyl-D-phenylalanine => N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23121", "l": "a dipeptide(out) + ATP + H2O => a dipeptide(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20223", "l": "(6R)-10-formyltetrahydrofolate + ADP + phosphate => (6S)-5,6,7,8-tetrahydrofolate + ATP + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77402", "l": "hydrogen cyanide + pentanal <=> (2S)-2-hydroxyhexanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55322", "l": "2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein] => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140485", "l": "5-aminolevulinic acid transmembrane transporter activity", "d": ["Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other."], "t": []}, {"i": "RHEA:64816", "l": "5-aminolevulinate(in) = 5-aminolevulinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49578", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + GTP + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38015", "l": "delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33156", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68091", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] <=> a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167134", "l": "Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46027", "l": "H2O2 + tetradecanoate <=> (3R)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58837", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139898", "l": "Caspase-8 activates BID by cleavage (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67364", "l": "H2O + L-threonyl-L-serine = L-serine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250264", "l": "TXNIP binds reduced thioredoxin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421161", "l": "hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34374", "l": "H2O + indole-3-acetamide <=> (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.835725707519245", "identifiers": [{"i": "GO:0005319", "l": "lipid transporter activity", "d": ["Enables the directed movement of lipids into, out of or within a cell, or between cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59028", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395517", "l": "NADPH transfers electrons to FDXR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047582", "l": "4-methyleneglutaminase activity", "d": ["Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61821", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose => epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655170", "l": "RCHY1 monoubiquitinates POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71334", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) <=> chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17826", "l": "ATP + D-glucose => ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641111", "l": "Parkin transfers Ub to misfolded proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350453", "l": "RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61121", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877493", "l": "TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41742", "l": "2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine => adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52735", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730872", "l": "Activation of Calcineurin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442732", "l": "NMDA-activated RASGRF1 activates RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71153", "l": "(E)-caffeoylpyruvate + CO2 + hnu => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871373", "l": "BMX phosphorylates RUFY1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28604", "l": "(1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166792", "l": "Conversion of C2 into C2a and C2b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13033", "l": "aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.26", "l": "\"galactose-6-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047328", "l": "acyl-phosphate-hexose phosphotransferase activity", "d": ["Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68311", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60832", "l": "a 5'-end triphospho-guanosine in mRNA + H2O = a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-532603", "l": "Nephrin mediated activation of N-WASP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42328", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.25", "l": "\"fructosyl amine oxidase (glucosone-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.16", "l": "\"tRNA-intron lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903878", "l": "11-deoxycorticosterone binding", "d": ["Binding to 11-deoxycorticosterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13176", "l": "H2O + NAD(+) + phosphonate <=> H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733331", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190256", "l": "FGFR1c binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41803", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11864", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine = dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.5.8.2", "l": "\"trimethylamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44760", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69173", "l": "Joining of adjacent Okazaki fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33408", "l": "ATP + glycine + H(+) => diphosphate + glycyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604763", "l": "Autocatalytic activation of MMP7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62873", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 => H2O + NADP(+) + semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43721", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine => juvenile hormone III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.245308234813891", "identifiers": [{"i": "GO:0005242", "l": "inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22495", "l": "H2O + N-formimidoyl-L-glutamate <=> formamide + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858480", "l": "WNT-dependent phosphorylation of DVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49017", "l": "aurachin C epoxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209828", "l": "Tryptophan is hydroxylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46215", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine <=> 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090079", "l": "GLB1 hydrolyses linker chain(2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592278", "l": "Autocatalytic activation of proMMP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627104", "l": "XIAP binds CASP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74091", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75172", "l": "Formation of RAD50:MRE11 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0008131", "l": "primary amine oxidase activity", "d": ["Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.159", "l": "\"dolabradiene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.3", "l": "\"uridine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14972", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34978", "l": "(R)-pantothenate(in) <=> (R)-pantothenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74032", "l": "L-alanine(in) + L-cysteine(out) => L-alanine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019163", "l": "pyridoxamine-phosphate transaminase activity", "d": ["Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49607", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138432", "l": "DVL2 is phosphorylated by PKC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0052743", "l": "inositol tetrakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30441", "l": "2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69412", "l": "2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54844", "l": "H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047114", "l": "kynurenate-7,8-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39882", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663785", "l": "CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51034", "l": "dichlorochromopyrrolate + H(+) + NH4(+) => 7-chloroindole-3-pyruvate imine dimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41458", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77573", "l": "a 1,3-diacylglycerol + CoA => a 1-acylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43081", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004617", "l": "phosphoglycerate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661230", "l": "MT1A binds arsenic (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61564", "l": "a tetracycline + H(+) + NADPH + O2 = a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77250", "l": "H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] <=> L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837625", "l": "hRSV A enters host cell through macropinocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019727", "l": "mevaldate reductase (NAD+) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + NAD+ = H+ + mevaldate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017061", "l": "S-methyl-5-thioadenosine phosphorylase activity", "d": ["Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050398", "l": "wax-ester hydrolase activity", "d": ["Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198733", "l": "ERK5 is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29161", "l": "3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a menaquinol(in) + 2 H(+)(out) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17238", "l": "ATP + FMN + H(+) => diphosphate + FAD", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16129", "l": "NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal", "d": [], "t": []}, {"i": "EC:1.1.1.65", "l": "\"pyridoxine 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688797", "l": "ATXN3 family cleave Ub chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0010852", "l": "cyclase inhibitor activity", "d": ["Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76893", "l": "2-hydroxyacetophenone + H(+) + NADH + NH4(+) => 2-hydroxy-1-phenylethan-1-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45935", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24064", "l": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen", "d": [], "t": []}, {"i": "EC:4.2.1.24", "l": "\"porphobilinogen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60120", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine = H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.363", "l": "\"pre-sodorifen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140809", "l": "histone H4R3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H4 L-arginyl (position 3)= histone H4 L-citrullyl (position 3) + NH4+, resulting in histone H4 citrullination at position 3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035500", "l": "MH2 domain binding", "d": ["Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70596", "l": "GOT2 dimer deaminates L-Asp (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033415", "l": "UGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37174", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016992", "l": "lipoate synthase activity", "d": ["Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564184", "l": "Collagen type IX degradation by MMP3,13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66420", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46870", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli) => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204465", "l": "Basigin interacts with CD43 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62251", "l": "chloroacetaldehyde + H2O + NADP(+) <=> chloroacetate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56581", "l": "6-thioguanine + S-adenosyl-L-methionine => 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13157", "l": "(R)-glycerate + CO2 + NADP(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004865", "l": "protein serine/threonine phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016819", "l": "hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-."], "t": []}, {"i": "EC:3.6.2.-", "l": "\"In sulfonyl-containing anhydrides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62919", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine <=> an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32002", "l": "(2E,6E)-farnesyl diphosphate <=> bicyclogermacrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187382", "l": "Degradation of ubiquitinated SMAD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20912", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene", "d": [], "t": []}, {"i": "EC:4.2.3.17", "l": "\"taxadiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33314", "l": "2 A + hydroxylamine + NH4(+) <=> 2 AH2 + H(+) + H2O + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667563", "l": "AVPR2 bind desmopressin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383190", "l": "HCO3- transport through ion channel (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11066", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 1,6-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24767", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45172", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59012", "l": "cycloartenol + S-adenosyl-L-methionine = 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404134", "l": "RBP4:atROL binds TTR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202328", "l": "Translocation of PKC theta to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16058", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53090", "l": "2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69616", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55316", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) = 4 H(+) + 3 NADH + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30845", "l": "formate + H(+) + maleamate => H2O + N-formylmaleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000310", "l": "AURKA phosphorylates PLK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63002", "l": "(11Z,14Z,17Z)-eicosatrienoate + NH4(+) => (11Z,14Z,17Z)-eicosatrienamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534096", "l": "METAP1/2 demethylates GNAT1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0070990", "l": "snRNP binding", "d": ["Binding to a small nuclear ribonucleoprotein particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63196", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH = (10bR,4aS)-oxomaritidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809663", "l": "Formation of hair keratin fibres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73201", "l": "maleate(out) + sulfate(in) => maleate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38568", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63303", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21313", "l": "2,5-dihydroxybenzoate + H(+) => CO2 + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2152276", "l": "Secretion of transmembrane collagens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42290", "l": "(8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] => 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051737", "l": "GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74311", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13808", "l": "A + a 3-oxo-5alpha-steroid <=> a 3-oxo-Delta(4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023178", "l": "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483089", "l": "PE is converted to PS by PTDSS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36255", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": [], "t": []}, {"i": "EC:1.14.16.5", "l": "\"alkylglycerol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204500", "l": "CyP60 chaperones Basigin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008489", "l": "UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62970", "l": "H(+) + NADPH + pyruvate => (R)-lactate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68962", "l": "7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxycoumarin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34637", "l": "H2O + NADP(+) + pentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65852", "l": "a 3-oxo-Delta(1)-steroid + H2O = a 1-hydroxy-3-oxo steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14536", "l": "creatinine + H2O <=> creatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9834821", "l": "p-PRKRA dimer binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1990472", "l": "piRNA dual-strand cluster binding", "d": ["Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48786", "l": "D-erythrose 4-phosphate => D-erythrulose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664273", "l": "SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481010", "l": "Surface deployment of platelet dense granule membrane components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.13", "l": "\"clostridial aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34664", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026916", "l": "GGT hydrolyses RCTR2 to RCTR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66557", "l": "dopamine + L-glutaminyl-[protein] => 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15648", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] <=> 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42500", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44632", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.80", "l": "\"(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72494", "l": "citrate(out) + maleate(in) <=> citrate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68422", "l": "(2R,3S)-iso(homo)3citrate => cis-(homo)3aconitate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51660", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 = an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77571", "l": "a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25249", "l": "H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13901", "l": "H2O + N-(aminomethyl)urea = N-(hydroxymethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29775", "l": "alpha-D-ribose 1-phosphate + ATP = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.239", "l": "\"alpha-D-ribose-1-phosphate 5-kinase (ATP)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67797", "l": "a ribonucleotidyl-ribonucleotide-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.33", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987214", "l": "p-STAT3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357828", "l": "RIPK1 is cleaved by CASP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34611", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose = H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49152", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909552", "l": "Phosphorylation of STAT1 at Ser727 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25580", "l": "alpha-L-fucose = beta-L-fucose", "d": [], "t": []}, {"i": "EC:5.1.3.29", "l": "\"L-fucose mutarotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70502", "l": "D-galactose(out) + 2 Na(+)(out) <=> D-galactose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22975", "l": "butanal + CoA + NADP(+) <=> butanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37700", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32892", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 => alpha-pinene oxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52830", "l": "(3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-isodihydrocarvone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33777", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37948", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72055", "l": "glycodeoxycholate(out) + 2 Na(+)(out) = glycodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018805", "l": "benzylsuccinate synthase activity", "d": ["Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418581", "l": "Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371537", "l": "DBC1 binds SIRT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59519", "l": "acetylsalicylate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62250", "l": "chloroacetate + 2 H(+) + NADPH => chloroacetaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30015", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848758", "l": "PTK6 phosphorylates AKT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43699", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "45.513384614968253", "identifiers": [{"i": "GO:0015075", "l": "monoatomic ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382056", "l": "Crk binds to the active PDGF receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031712", "l": "B1 bradykinin receptor binding", "d": ["Binding to a B1 bradykinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55447", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50736", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite = a quinol + thiosulfate", "d": [], "t": []}, {"i": "EC:1.8.5.5", "l": "\"thiosulfate reductase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54092", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607721", "l": "Activation of NIK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27774", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14896", "l": "D-ornithine <=> (2R,4S)-2,4-diaminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726875", "l": "HCNs:cAMP bind SNIs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61798", "l": "AMP + L-tryptophyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58374", "l": "(2E)-octenal + H(+) + NADPH => (E)-oct-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374680", "l": "L1 trans-homophilic interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58507", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033779", "l": "5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73321", "l": "cimicifugate K + CoA => (2R,3S)-piscidate + (E)-4-coumaroyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046911", "l": "metal chelating activity", "d": ["The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56251", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18646", "l": "2 putrescine => NH4(+) + sym-homospermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64563", "l": "butan-2-ol + NAD(+) <=> butan-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43865", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38445", "l": "a wax ester + CoA => a fatty acyl-CoA + a long chain fatty alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390595", "l": "Calcium Binds Troponin-C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23663", "l": "4-imidazolone-5-propanoate + H2O <=> N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209815", "l": "Tyrosine is monoiodinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77105", "l": "2-(9Z-octadecenoyl)-glycerol + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13110", "l": "2-acetamidofluorene + H2O + NAD(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52324", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.14.14.47", "l": "\"nitric-oxide synthase (flavodoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183072", "l": "EGFR non-clathrin mediated endocytosis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76621", "l": "capsiate + CoA => (6E)-8-methylnon-6-enoyl-CoA + 4-hydroxy-3-methoxy-benzenemethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76310", "l": "L-aspartate(in) + L-glutamate(out) <=> L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047998", "l": "hyoscyamine (6S)-dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047611", "l": "acetylspermidine deacetylase activity", "d": ["Catalysis of the reaction: N(8)-acetylspermidine + H2O = acetate + spermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59321", "l": "D-cellobiono-1,5-lactone + H2O => 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15201", "l": "6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.108", "l": "\"6-hydroxymellein O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362386", "l": "Glycosylation of Hh (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34997", "l": "L-rhamnose(out) => L-rhamnose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67837", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354060", "l": "Translocation of RIAM to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68252", "l": "L-tryptophan(in) + Na(+)(in) = L-tryptophan(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395320", "l": "Latent TGF-beta-1 binds integrins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47934", "l": "(2S)-3-sulfolactate + 2 H(+) + NADH => (2S)-3-sulfolactaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.6", "l": "\"acetolactate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799815", "l": "TP53 family members bind the FAS gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57975", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5225649", "l": "RBBP7 binds histone H3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853911", "l": "VENTX stimulates TP53 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51743", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45844", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) = 3-oxooctanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68595", "l": "ORC2 binds ORC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41949", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109702", "l": "PDPK1 phosphorylates AKT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16607", "l": "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+) => dodecanoyl-CoA + H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640195", "l": "RRAGA,B hydrolyzes GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804266", "l": "CHEK2 phosphorylates TTC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70510", "l": "LDH tetramer oxidises LACT to PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55346", "l": "1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53979", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39602", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14665", "l": "guanine + H(+) + H2O = NH4(+) + xanthine", "d": [], "t": []}, {"i": "EC:3.5.4.3", "l": "\"guanine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41844", "l": "(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0047865", "l": "dimethylglycine dehydrogenase activity", "d": ["Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604732", "l": "Autocatalytic activation of proMMP13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25144", "l": "3-hydroxy-L-kynurenine + H2O => 3-hydroxyanthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23265", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22732", "l": "4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70372", "l": "3-oxosphinganine + decanoyl-CoA => CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45895", "l": "an N-acylsphing-4-enine + CDP-ethanolamine <=> an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332356", "l": "CAMK2 binds MAP3K7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59199", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP <=> AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57193", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glycolate + H(+) + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427366", "l": "Transcription of intergenic spacer of the rRNA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625416", "l": "Anterograde IFT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211960", "l": "CYP2U1 19-hydroxylates ARA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38954", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) <=> ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57670", "l": "(+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111879", "l": "PIP2 hydrolysis (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11437", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 => 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854209", "l": "TBC1D10A binds JFC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.97", "l": "\"1,3-beta-D-glucan phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428909", "l": "Activated TP receptor binds G-protein  G13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14971", "l": "(E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3791319", "l": "NID1 degradation by MMP19 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211951", "l": "CYP1B1 4-hydroxylates EST17b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63214", "l": "5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390673", "l": "CHRM2,4 bind acetylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69533", "l": "(2S)-2-amino-4-deoxychorismate => 4-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174731", "l": "Degradation of newly synthesized ApoB-48 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022856", "l": "protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019905", "l": "syntaxin binding", "d": ["Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58561", "l": "15alpha-stemmadenine intermediate II + NADP(+) => 15alpha-stemmadenine intermediate I + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47717", "l": "4-pregnen-20,21-diol-3-one + NAD(+) => 21-hydroxyprogesterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45565", "l": "2-epi-5-epi-valiolone => 5-epi-valiolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671919", "l": "Activated CIT phosphorylates MRLCs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19961", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": [], "t": []}, {"i": "EC:2.7.1.77", "l": "\"nucleoside phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35644", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018798", "l": "gallate decarboxylase activity", "d": ["Catalysis of the reaction: gallate + H+ = CO2 + pyrogallol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61447", "l": "a tetracycline + H(+) + NADPH + O2 <=> an 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42387", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) <=> 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30562", "l": "GTP + H2O <=> guanosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61434", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (R)-8-oxocitronellyl enol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22324", "l": "H2O + leukotriene A4 = leukotriene B4", "d": [], "t": []}, {"i": "EC:3.3.2.6", "l": "\"leukotriene-A4 hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20242", "l": "nicotinate + S-adenosyl-L-methionine => N-methylnicotinate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69181", "l": "ADP + thiamine diphosphate => AMP + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27288", "l": "diacetyl + H(+) + NADH => (S)-acetoin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31760", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35632", "l": "cyanidin + UDP-alpha-D-galactose => cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620103", "l": "ALDH2 transforms GTN to NO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77640", "l": "3'-phosphoadenylyl sulfate + H2O => adenosine 5'-phosphosulfate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140903", "l": "histone H3R26 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 26) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 26). This reaction is the addition of a methyl group to the arginine residue at position 26 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68209", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110157", "l": "UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50126", "l": "8-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061656", "l": "SUMO conjugating enzyme activity", "d": ["Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085992", "l": "SUMOylation of DAXX with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55116", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37175", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061990", "l": "beta-ketodecanoyl-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202692", "l": "PIP3 binds to RhoA and activates it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314686", "l": "ASA- acetylates PTGS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.222", "l": "\"aurachin C monooxygenase/isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662613", "l": "MT3 exchanges zinc for copper (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76684", "l": "ATP + CoA + sulfoacetate => ADP + phosphate + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17862", "l": "21-hydroxyprogesterone => 20-hydroxy-3-oxopregn-4-en-21-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082391", "l": "Trimerization of HSF1 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10817", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside => L-fucose + methyl beta-D-galactoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37595", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10000", "l": "H2O + pentanamide = NH4(+) + pentanoate", "d": [], "t": []}, {"i": "EC:3.5.1.50", "l": "\"pentanamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140662", "l": "ATP-dependent protein folding chaperone", "d": ["Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73723", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11S)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41345", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677050", "l": "Formation of the GCN5-ATAC complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604712", "l": "Initial activation of proMMP7 by trypsin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64205", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035954", "l": "Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33402", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) <=> L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73086", "l": "chrysoeriol + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + velutin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396009", "l": "STING binds c-di-GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24555", "l": "5alpha-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008763", "l": "UDP-N-acetylmuramate-L-alanine ligase activity", "d": ["Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11113", "l": "H2O + isochorismate => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769397", "l": "SOST binds LRP5/6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350385", "l": "DSH binds to RAC1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805103", "l": "AURKA phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482773", "l": "MLCL transports from the IM to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229132", "l": "AP4 binds APP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047108", "l": "(R)-3-hydroxyacid-ester dehydrogenase activity", "d": ["Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181355", "l": "Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40447", "l": "(2R)-pristanoyl-CoA = (2S)-pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40724", "l": "(9E)-octadecenoyl-CoA + H2O => (9E)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23905", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] => 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9736953", "l": "FURIN translocates to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847534", "l": "RAB43 hydrolyses GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.48", "l": "\"ceramide phosphoethanolamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047019", "l": "indole-3-acetaldehyde reductase (NADPH) activity", "d": ["Catalysis of the reaction: indole-3-ethanol + NADP+ = (indol-3-yl)acetaldehyde + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74986", "l": "Elongation of pre-rRNA transcript (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70179", "l": "2 D-maltotetraose = alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420688", "l": "GABAB heterodimeric receptor binds GABA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050361", "l": "tryptophan 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45730", "l": "(E)-caffeyl aldehyde + H(+) + NADPH => (E)-caffeyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58313", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O => 25-substituted-cholesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51180", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65208", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O = (S)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19796", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31478", "l": "soyasapogenol B + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58983", "l": "citral + H2O + O2 <=> 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42358", "l": "3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA => (9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67247", "l": "3-deoxyglucosone + H2O + NAD(+) <=> 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023171", "l": "Insulin secretory granule translocates across the cortical actin network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70323", "l": "2,3-dioxo-L-gulonate = 2-carboxy-L-lyxonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44737", "l": "acetyl-CoA + dihydroxyacetone phosphate => 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73392", "l": "H(+)(in) + phosphate(in) + sulfate(out) => H(+)(out) + phosphate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696356", "l": "OSCAR binds collagen and SP-D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56212", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63627", "l": "hexadecanoyl-AMP + holo-[ACP] <=> AMP + H(+) + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49305", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70663", "l": "4-hydroxy-L-proline(in) + H(+)(in) = 4-hydroxy-L-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73646", "l": "CTP(out) + IDP(in) <=> CTP(in) + IDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728664", "l": "GLP1R binds GLP1R agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51535", "l": "H(+) + NADPH + O2 + urate <=> 5-hydroxyisourate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10278", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702818", "l": "CALCR binds erenumab (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49535", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O <=> ethylene glycol + H(+) + terephthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050607", "l": "mycothiol-dependent formaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48571", "l": "3-chlorocatechol + O2 <=> (2E,4Z)-2-chloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34066", "l": "2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024386", "l": "Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30427", "l": "(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.77", "l": "\"(+)-germacrene D synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13905", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.206", "l": "\"lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106430", "l": "dihydroorotate dehydrogenase (quinone) activity", "d": ["(S)-dihydroorotate + a quinone = orotate + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77540", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69753", "l": "(E)-cinnamoyl-CoA + CO2 + H2O2 => benzylmalonyl-CoA + H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21091", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 <=> a flavonol + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65955", "l": "2 a quinone + H(+) + NADH <=> 2 a 1,4-benzosemiquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22430", "l": "2 H2O + isopenicillin N => N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23448", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.38", "l": "\"3-deoxy-manno-octulosonate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065958", "l": "An unknown protease degrades ACACA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36918", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28972", "l": "H(+)(in) + shikimate(in) => H(+)(out) + shikimate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39330", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437118", "l": "GPVI stimulates PI3K beta, gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25543", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70486", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42250", "l": "3-oxohexanoyl-[ACP] + CO2 + CoA => butanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59714", "l": "D-maltotetraonate + H(+) => D-maltotetraono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13508", "l": "choline + O2 <=> betaine aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50523", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34264", "l": "dimethylallyl diphosphate + fumigaclavine A => diphosphate + fumigaclavine C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35486", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36379", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH = 4alpha-methylzymosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204485", "l": "Basigin binds CyPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640195", "l": "RRAGA,B hydrolyzes GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21620", "l": "FMNH2 + NAD(+) = FMN + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090736", "l": "MATH domain binding", "d": ["Binding to a meprin and TRAF homology (MATH) domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39116", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15514", "l": "ATP + keto-D-tagatose => ADP + H(+) + keto-D-tagatose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65067", "l": "dimethylallyl diphosphate + siccayne <=> diphosphate + pestalodiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17287", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48752", "l": "2-oxoglutarate + O2 + validamycin A = CO2 + H(+) + succinate + validamycin B", "d": [], "t": []}, {"i": "EC:1.14.11.52", "l": "\"validamycin A dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17847", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866941", "l": "MID1IP1 binds THRSP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800794", "l": "PIDD1 associates with CRADD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28615", "l": "(1Z,2S)-2-methylbutanal oxime => (2S)-2-methylbutanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033932", "l": "1,3-alpha-L-fucosidase activity", "d": ["Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102105", "l": "demethoxycurcumin synthase activity from feruloylacetyl-CoA", "d": ["Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60514", "l": "an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine => a guanosine in miRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474266", "l": "Formation of collagen fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53684", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53780", "l": "beta-muricholate + lithocholoyl-CoA = beta-muricholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58464", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35113", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-L-idonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52014", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454916", "l": "The ABCC family mediates organic anion transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65425", "l": "AMP(in) + NAD(+)(out) => AMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29595", "l": "CoA + NADP(+) + sulfoacetaldehyde = H(+) + NADPH + sulfoacetyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.1.81", "l": "\"sulfoacetaldehyde dehydrogenase (acylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14839", "l": "H(+) + H2O2 + oxalate => glyoxylate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:1990459", "l": "transferrin receptor binding", "d": ["Binding to a transferrin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24148", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.6", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730842", "l": "PI3K associates with phosphorylated GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37137", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.-", "l": "\"Phosphotransferases with a nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052899", "l": "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.6", "l": "\"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781922", "l": "USP13 binds UFD1L:SKP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65707", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose <=> alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31900", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45907", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + epivancomycin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31853", "l": "parkeol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36992", "l": "phosphate + UMP => alpha-D-ribose 1,5-bisphosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34832", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601897", "l": "MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30588", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide => 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53089", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56490", "l": "H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51992", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.43", "l": "\"(methylsulfanyl)alkanaldoxime N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34420", "l": "(+)-lariciresinol + NADP(+) => (+)-pinoresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29355", "l": "dUMP + H2O = 2'-deoxyuridine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797245", "l": "Expression of FASLG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6786650", "l": "DDHD1,2 hydrolyse PA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71936", "l": "glycocholate(out) + 2 Na(+)(out) => glycocholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102302", "l": "mycinamicin VI 2''-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76373", "l": "n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) => n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74801", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186819", "l": "SH2 domain of Src binds to the active receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60617", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine => ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15189", "l": "2 Fe(III)-[cytochrome c553] + formate = CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": [], "t": []}, {"i": "EC:1.17.2.3", "l": "\"formate dehydrogenase (cytochrome c-553)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209075", "l": "Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102938", "l": "orcinol O-methyltransferase activity", "d": ["Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38058", "l": "CTP + phytol <=> CDP + H(+) + phytyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679028", "l": "JAK3 binds JAK3 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981621", "l": "Neuroglobin:oxygen dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900747", "l": "NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205306", "l": "Interaction of SHP1 and KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77204", "l": "3'-phosphoadenylyl sulfate + deoxycholate => 3alpha-sulfodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373732", "l": "Nephrin trans-homophilic interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31217", "l": "(5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH => (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56246", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein] => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835411", "l": "FA core complex:HSP70s binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617668", "l": "HOXB3 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106235", "l": "ceramide-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate."], "t": []}, {"i": "RHEA:50888", "l": "an N-acylsphingoid base 1-phosphate + H2O = an N-acyl-sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83650", "l": "FasL:Fas binds FADD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448702", "l": "Caspase-1 active tetramer formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18213", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.33", "l": "\"glucose-1-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389978", "l": "alpha-tubulin:GTP + Cofactor E ->  alpha-tubulin:GTP:Cofactor E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16921", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.155", "l": "\"alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14245", "l": "ATP + H2O = AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010429", "l": "methyl-CpNpN binding", "d": ["Binding to a methylated cytosine/unspecified/unspecified trinucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30043", "l": "fumarate + L-aspartate = iminosuccinate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213464", "l": "RIPK1 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097098", "l": "DNA/RNA hybrid annealing activity", "d": ["An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15149", "l": "O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40568", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 => A + dTDP-beta-L-evernitrose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74128", "l": "peonidin + UDP-alpha-D-galactose => peonidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43581", "l": "A + D-arginine => AH2 + iminoarginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76324", "l": "L-aspartate(in) + L-valine(out) => L-aspartate(out) + L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40020", "l": "ent-copalyl diphosphate + H2O => (-)-ent-copalol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11193", "l": "an (S)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.5", "l": "\"Xaa-methyl-His dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620103", "l": "ALDH2 transforms GTN to NO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50824", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209960", "l": "Diiodinated tyrosine can be deiodinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034555", "l": "3,3'-dibromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66874", "l": "9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72185", "l": "mRNA polyadenylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22446", "l": "(E)-coniferaldehyde + H(+) + NADPH => (E)-coniferol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18376", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176298", "l": "Activation of claspin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18228", "l": "[N-(6-aminohexanoyl)](n) + H2O <=> 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65042", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54493", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23595", "l": "glycerol + NADP(+) <=> D-glyceraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955844", "l": "RBKS phosphorylates ribose to R5P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62506", "l": "3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018693", "l": "ethylbenzene hydroxylase activity", "d": ["Catalysis of the reaction: A + ethylbenzene + H2O = (S)-1-phenylethanol + AH(2)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371422", "l": "ATP hydrolysis by HSP70 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40526", "l": "a quinone + succinate <=> a quinol + fumarate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21374", "l": "CO2 + ethanol + NH4(+) => H(+) + H2O + urethane", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.153", "l": "\"sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430308", "l": "PARVB interacts with Alpha-actinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16825", "l": "ATP + uridine = ADP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56396", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55255", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5606996", "l": "Soluble PROCR binds activated protein C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27957", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + presilphiperfolan-8beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71120", "l": "H(+) + hispidin + NADPH + O2 => 3-hydroxyhispidin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51500", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59203", "l": "ATP + docosanoate + H(+) <=> diphosphate + docosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012835", "l": "GDIs block activation of RHOA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12485", "l": "a ribonucleoside 5'-phosphate + H2O => a ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004640", "l": "phosphoribosylanthranilate isomerase activity", "d": ["Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749350", "l": "ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71107", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) = L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63131", "l": "H2O + N-docosanoyl-ethanolamine <=> docosanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16612", "l": "AMP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42272", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54159", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53482", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052900", "l": "spermine oxidase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermine = 1,3-diaminopropane + H2O2 + N-(3-aminopropyl)-4-aminobutanal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043811", "l": "phosphate:acyl-[acyl carrier protein] acyltransferase activity", "d": ["Catalysis of the reaction: a fatty acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46392", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372542", "l": "Loading of dopamine into synaptic veiscles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2201341", "l": "Endocytosis of TRAM (TICAM2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73949", "l": "(4E,6E)-allo-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36777", "l": "alpha-L-Fuc-(1->2)-[alpha-D-Gal-(1->3)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112342", "l": "Inactivation of MAP2K1 by CDK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993802", "l": "HLCS biotinylates PC:Mn2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004977", "l": "melanocortin receptor activity", "d": ["Combining with melanocortin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183122", "l": "Factor D cleaves C3b-bound Factor B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709109", "l": "DHFR dimer binds DHFR inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603062", "l": "Complexed PIWIL2 binds  pre-piRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76731", "l": "a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20258", "l": "3-methyloxindole + NADP(+) => 3-methyleneoxindole + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66538", "l": "25-hydroxycholest-4,6-dien-3-one + AH2 => A + cholest-4,6-dien-3-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57754", "l": "C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60365", "l": "H(+)(out) + myo-inositol(out) => H(+)(in) + myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43727", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25527", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804266", "l": "CHEK2 phosphorylates TTC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57476", "l": "dodecanoate + H2O2 = 2-hydroxydodecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190829", "l": "Lysosomal degradation of gap junction plaques (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75064", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55534", "l": "2-phenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65053", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) => 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42978", "l": "2-aminoprop-2-enoate + indole => L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48044", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O = D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19121", "l": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.3", "l": "\"ABC-type glutathione-S-conjugate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430347", "l": "MigFilin associates with Filamin and F-actin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35766", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53247", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53915", "l": "butanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28087", "l": "2 H2O2 + Reactive Blue 5 => 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035488", "l": "cytosine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a C/T mispair."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.31", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57753", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46312", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA = 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21455", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 <=> a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.1", "l": "\"ethanolaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430096", "l": "GP1b-IX-V binds filamin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44878", "l": "a 3-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947531", "l": "Molybdenum ion transfer onto molybdopterin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33485", "l": "CoA + ergosteryl ester => an acyl-CoA + ergosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18959", "l": "(1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024100", "l": "GLCE epimerises GlcA to IdoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15219", "l": "CoA + ecdysone hexadecanoate => ecdysone + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693540", "l": "MRN activates ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68065", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616243", "l": "CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953111", "l": "E2F6 binds TFDP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74227", "l": "H2O + L-threonyl-tRNA(Ile) = L-threonine + tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52828", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 = (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222020", "l": "NUAK1 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222533", "l": "ERK1/2-activated AP1 complex binds KDM6B promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062050", "l": "GPI-mannose ethanolamine phosphate phosphodiesterase activity", "d": ["A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228940", "l": "Transcytosis and dissociation of botB:NTNHA:HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42027", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) <=> 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35310", "l": "H(+) + NADH + O2 + salicylate <=> 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.9.-", "l": "\"Phosphotransferases with paired acceptors\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36453", "l": "ADP + glycyl-L-glutamate(in) + H(+) + phosphate => ATP + glycyl-L-glutamate(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54582", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+) => a 5'-end dephospho-ribonucleoside-RNA + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16820", "l": "6-phospho-D-gluconate + NADP(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45390", "l": "(9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine => H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23157", "l": "(E)-(indol-3-yl)acetaldehyde oxime => (indol-3-yl)acetonitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76951", "l": "H2O + N-methyl-2-methylpropanamine + NAD(+) = 2-methylpropanal + H(+) + methylamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39963", "l": "2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55130", "l": "(2E)-5-methylhexenoyl-[ACP] + H2O => (3R)-hydroxy-5-methylhexanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72492", "l": "citrate(out) + maleate(in) => citrate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18793", "l": "alpha-D-ribose 1-phosphate = D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46466", "l": "(24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036012", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052599", "l": "methylputrescine oxidase activity", "d": ["Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73754", "l": "(R)-adrenaline(in) + 2 H(+)(out) <=> (R)-adrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10813", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + N-succinyl-L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45454", "l": "ethanolamine + tetradecanoate => H2O + N-tetradecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031768", "l": "ghrelin receptor binding", "d": ["Binding to a ghrelin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72898", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61525", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036428", "l": "adenosylcobinamide kinase (GTP-specific) activity", "d": ["Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050448", "l": "beta-cyclopiazonate dehydrogenase activity", "d": ["Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.25", "l": "\"mugineic-acid 3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39235", "l": "(3R)-hydroxytriacontanoyl-CoA = (2E)-triacontenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11039", "l": "a quaternary ammonium(out) + ATP + H2O <=> a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21447", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) <=> H(+) + NADH + trans-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21792", "l": "NADP(+) + propan-2-ol = acetone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.80", "l": "\"isopropanol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49203", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917987", "l": "TFRC dimer binds 2xholoTF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17139", "l": "thromboxane A2 => prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63506", "l": "13-dihydrodaunorubicin + NADP(+) => daunorubicin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654544", "l": "Ligand-independent dimerization of overexpressed FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013145", "l": "RAC1 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14982", "l": "NADP(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58181", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545203", "l": "Deacetylation of cleaved cohesin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56838", "l": "5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine => [PQQ precursor protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.25", "l": "\"beta-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31777", "l": "11-cis-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48301", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester => glycerol + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38577", "l": "(9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380930", "l": "Phosphorylated AMPK binds AMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350901", "l": "Iodide is organified (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52114", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22539", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine <=> (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28880", "l": "H(+)(in) + L-tryptophan(in) => H(+)(out) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72304", "l": "L-glutamate(in) + L-thyroxine(out) => L-glutamate(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004450", "l": "isocitrate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373741", "l": "SDK2 homophillic interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30589", "l": "2-demethylmenaquinone-8 + dimethyl sulfide + H2O => 2-demethylmenaquinol-8 + dimethyl sulfoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392263", "l": "AVP(20-28) binds AVPR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72171", "l": "2 Na(+)(out) + taurohyocholate(out) = 2 Na(+)(in) + taurohyocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66906", "l": "AH2 + cannabichromenate => A + cannabinerolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39874", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 3-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635843", "l": "GLI translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26214", "l": "9alpha-copalyl diphosphate + H2O => aphidicolan-16beta-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67174", "l": "formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite => O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617825", "l": "TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14301", "l": "4-pyridoxolactone + H2O = 4-pyridoxate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.27", "l": "\"4-pyridoxolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51662", "l": "an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+) => an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22173", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose => H(+) + sucrose 6(F)-phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875531", "l": "MET binds TNS4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40306", "l": "A + dodecanedioyl-CoA <=> (2E)-dodecenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14612", "l": "D-sorbitol + NADP(+) <=> H(+) + keto-L-sorbose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047147", "l": "trimethylsulfonium-tetrahydrofolate N-methyltransferase activity", "d": ["Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29960", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008664", "l": "2'-5'-RNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10456", "l": "acetyl-CoA + D-maltose = 1-O-acetylmaltose + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.79", "l": "\"maltose O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48631", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018588", "l": "tri-n-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047755", "l": "isocitrate epimerase activity", "d": ["Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772430", "l": "CTNNBIP1 binds beta-catenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106026", "l": "Gly-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645428", "l": "ALPK1 binds ADP-heptose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730856", "l": "Autophosphorylation of PAK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33836", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247849", "l": "WLS dissociates from retromer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20622", "l": "ATP + H2O + Zn(2+)(in) => ADP + H(+) + phosphate + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624112", "l": "CEBPA binds CDK4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686578", "l": "Activated ATM phosphorylates ABL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111930", "l": "Adenylate cyclase produces cAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174058", "l": "Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16587", "l": "2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694428", "l": "LMAN family proteins bind glycosylated cargo (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55152", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] = (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.14", "l": "\"L-prolyl-[peptidyl-carrier protein] dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047084", "l": "methyltetrahydroprotoberberine 14-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191303", "l": "FDPS dimer transfers IPPP to GPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55053", "l": "H2O + pentanoyl-CoA => CoA + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57615", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH <=> 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682992", "l": "KDM4A,B bind H4K20Me2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68610", "l": "Formation of ORC(2-5) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830365", "l": "Expression of WFDC2 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196017", "l": "Dynamin is recruited to the gap junction plaque (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11721", "l": "ATP + 2 H2O + N-methylhydantoin => ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47913", "l": "6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694409", "l": "Nucleotide exchange on RAB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0004555", "l": "alpha,alpha-trehalase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12797", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + scopolamine + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.13", "l": "\"6beta-hydroxyhyoscyamine epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103039", "l": "protein methylthiotransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31436", "l": "(2E,6E)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25266", "l": "2-phenylethylamine + H2O + O2 => 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102496", "l": "GA5 2,3 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate = gibberellin A6 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39970", "l": "2-aminobut-2-enoate <=> 2-iminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58210", "l": "AH2 + alstonine => A + dihydroalstonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75784", "l": "ADP(in) => ADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70677", "l": "L-arginyl-L-phenylalanine + Met-enkephalin => H2O + Met-enkephalin-Arg-Phe", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27502", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine => 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27468", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24943", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28343", "l": "dITP + H2O => dIMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59470", "l": "an S-substituted L-cysteinylglycine + L-glutamate => an S-substituted glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659820", "l": "RB1 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865275", "l": "PDGF-BB clevage by Furin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0015296", "l": "monoatomic anion:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938356", "l": "RMB14 binds RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0031835", "l": "substance P receptor binding", "d": ["Binding to a substance P receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801415", "l": "TP53 stimulates NLRC4 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47354", "l": "an aliphatic alcohol + H(+) + hexanoate => a hexanoate ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161293", "l": "Tropoelastin forms aggregate globules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28191", "l": "2'-deoxyadenosine + H(+) + H2O => 2'-deoxyinosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0004030", "l": "aldehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49870", "l": "(+)-dehydrodiconiferyl acid ketone + a quinol => (+)-dehydrodiconiferyl acid + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30989", "l": "(17Z)-protosta-17(20),24-dien-3beta-ol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13530", "l": "(3S)-citramalate => H2O + mesaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0055103", "l": "ligase regulator activity", "d": ["Binds to and modulates the activity of a ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728804", "l": "SARS-CoV-1 nsp1 binds to PPIase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16169", "l": "ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.2", "l": "\"glutamine synthetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33941", "l": "H2O + N(omega)-hydroxy-L-arginine + NAD(+) => H(+) + L-arginine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11786", "l": "H(+) + NADPH + NH4(+) + oxaloacetate => H2O + L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67788", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56097", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) => [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669158", "l": "NF2 binds PAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203973", "l": "Vesicle budding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74784", "l": "tyramine(in) => tyramine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852552", "l": "MST1R autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008510", "l": "sodium:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195739", "l": "Palmitoylation of cysteine residues on M2 in the cis-golgi network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62296", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) = (+)-malbrancheamide + 2 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373042", "l": "2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051736", "l": "ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA."], "t": []}, {"i": "RHEA:54580", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55349", "l": "all-trans-retinol => 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9833777", "l": "PKR binds activating host RNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39567", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64397", "l": "glycyl-sarcosine(out) + H(+)(out) => glycyl-sarcosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53764", "l": "allocholate + lithocholoyl-CoA = allocholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.-.-", "l": "\"Other enzymes using O2 as oxidant\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229132", "l": "AP4 binds APP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62611", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 <=> S-sulfanylglutathione + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10126", "l": "benzyl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51911", "l": "dATP + H2O <=> dADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681616", "l": "AP2 binds chlorpromazine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005053", "l": "peroxisome matrix targeting signal-2 binding", "d": ["Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015621", "l": "ferric triacetylfusarinine C transmembrane transporter activity", "d": ["Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49934", "l": "(2E,5Z)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-178208", "l": "SMAD7 binds to SMURF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9650165", "l": "ASIC trimers bind H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014456", "l": "GDIs block activation of RHOG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27744", "l": "2-deoxy-alpha-D-ribose 1-phosphate + adenine => 2'-deoxyadenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696271", "l": "RND1 binds effectors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.3", "l": "\"protoporphyrinogen IX dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11187", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O <=> beta-alanine + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.2", "l": "\"diacylglycerol cholinephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042328", "l": "heparan sulfate N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52354", "l": "(24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65417", "l": "dGMP(in) + NAD(+)(out) => dGMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674093", "l": "PDGFRs bind type I TKI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31681", "l": "H2O2 + prosolanapyrone III => O2 + prosolanapyrone II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392874", "l": "Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67567", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate <=> adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61276", "l": "H2O + L-ornithine + O2 = 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57363", "l": "H2O + NADH <=> (6R)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14604", "l": "L-lysine + O2 <=> 5-aminopentanamide + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018756", "l": "RHOH binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41070", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0018169", "l": "ribosomal S6-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52818", "l": "an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55230", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863494", "l": "ASICs bind STOML3, (STOM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53192", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047694", "l": "barbiturase activity", "d": ["Catalysis of the reaction: barbiturate + H2O = malonate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481007", "l": "Exocytosis of platelet alpha granule contents (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67180", "l": "ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32636", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11607", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA <=> [O(7),N-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664879", "l": "ATM:PEX5 binds ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017083", "l": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43385", "l": "ATP + L-arginyl-[protein] => ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004831", "l": "tyrosine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69605", "l": "3',5'-cyclic UMP + diphosphate => UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29925", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69713", "l": "beta-D-glucose + N-hexadecanoylsphinganine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48831", "l": "H(+) + NADPH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453183", "l": "p-Y348-SYK dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30141", "l": "CoA + H(+) + octadecanoate => H2O + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11114", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate => H2O + isochorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37177", "l": "1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54647", "l": "trans-4-hydroxy-L-proline <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52073", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28245", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53573", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69966", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74718", "l": "Internalisation of the insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419011", "l": "Transhomodimerization of Nectins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70337", "l": "2-carboxy-L-lyxonate + H(+) => 2-carboxy-L-lyxonolactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "56.202863439151976", "identifiers": [{"i": "GO:0016705", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor."], "t": []}, {"i": "EC:1.14.-.-", "l": "\"Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050097", "l": "methylaspartate mutase activity", "d": ["Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17122", "l": "carbamoyl phosphate + L-lysine => H(+) + L-homocitrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.338", "l": "\"desmethylxanthohumol 6'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015127", "l": "bilirubin transmembrane transporter activity", "d": ["Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801089", "l": "TP53 stimulates RABGGTA expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050087", "l": "mannitol dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64261", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine => CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362522", "l": "ALDHs oxidise atRAL to atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25232", "l": "L-arabinitol + NADP(+) <=> H(+) + L-arabinose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036243", "l": "succinate-semialdehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005484", "l": "SNAP receptor activity", "d": ["Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47062", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73331", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA = cimicifugate E + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61616", "l": "H(+) + L-proline betaine + NADH + O2 = formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50836", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36220", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76265", "l": "ergothioneine(out) => ergothioneine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168136", "l": "Activated JNKs phosphorylate c-JUN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854222", "l": "TBC1D3 associates with RAB5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58193", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin => dihydrobisanhydrobacterioruberin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16329", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693783", "l": "NAALADases hydrolyse NAAG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65563", "l": "2-oxoglutarate + L-kynurenine <=> H2O + kynurenate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25152", "l": "2-oxoglutarate + L-phenylalanine = 3-phenylpyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856157", "l": "LAG3 (CD233) binds MHC II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39497", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.27", "l": "\"choloyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901514", "l": "ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56646", "l": "a pseudouridine in mRNA => a uridine in mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57420", "l": "NADH + 2 oxidized [cytochrome P450] = H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70781", "l": "6-dehydro-D-glucose + H(+) + NADPH => D-glucose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24936", "l": "H2O + imidazol-4-one => N-formimidoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53950", "l": "ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate => ATP + holo-[BtrI ACP] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019198", "l": "transmembrane receptor protein phosphatase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019194", "l": "sorbose transmembrane transporter activity", "d": ["Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51667", "l": "D-5-phenylhydantoin + H2O <=> H(+) + N-carbamoyl-D-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34907", "l": "molybdate(in) = molybdate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37580", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67738", "l": "aceneuramate => N-acetyl-alpha-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362485", "l": "GHBP binds GH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27515", "l": "H2O + sphinganine 1-phosphate => phosphate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73779", "l": "dimethylallyl diphosphate + preechinulin = diphosphate + tardioxopiperazine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53558", "l": "18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66269", "l": "CoA + nonanoyl-AMP => AMP + H(+) + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76717", "l": "(17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018768", "l": "RHOU auto-activates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18564", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74448", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694527", "l": "Loss of SAR1B GTPase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33239", "l": "L-threonine + NAD(+) = aminoacetone + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59070", "l": "deoxyspectinabilin + S-adenosyl-L-homocysteine => demethyldeoxyspectinabilin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53122", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63475", "l": "all-trans-hexaprenol + ATP <=> ADP + all-trans-hexaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213195", "l": "Formation of anchoring fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21155", "l": "trans-4-hydroxy-L-proline <=> cis-4-hydroxy-D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40531", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004844", "l": "uracil DNA N-glycosylase activity", "d": ["Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632652", "l": "Hh-Npp binds CDON and PTCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28849", "l": "Li(+)(out) + melibiose(out) => Li(+)(in) + melibiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213462", "l": "RIPK3 binds RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34748", "l": "15-methylhexadecasphinganine + ATP => 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56483", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56313", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O => 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51246", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65412", "l": "dAMP(in) + NAD(+)(out) = dAMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044667", "l": "(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)."], "t": []}, {"i": "RHEA:29427", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22361", "l": "D-glutamate => 5-oxo-D-proline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42765", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0000049", "l": "tRNA binding", "d": ["Binding to a transfer RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814096", "l": "ARL1:GTP binds SCOC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76416", "l": "Benzene is hydroxylated to phenol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938231", "l": "RUNX1:CBFB binds CREBBP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33690", "l": "3'-N-debenzoyltaxol + benzoyl-CoA <=> CoA + H(+) + taxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.107", "l": "\"sanguinarine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190265", "l": "FGFR4 binds to FGF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.4", "l": "\"glutamate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190256", "l": "FGFR1c binds to FGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41720", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67115", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43685", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate => AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59189", "l": "L-histidine => D-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18472", "l": "an acyl-CoA + L-glutamine <=> an N(2)-acyl-L-glutamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111919", "l": "PKA phosphorylates CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374337", "l": "Apelin receptor binds to apelin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602484", "l": "Activation of proMMP11 by FURIN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31176", "l": "(2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14703", "l": "CoA-disulfide + H(+) + NADH => 2 CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25190", "l": "chloroacetate + H2O => chloride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047629", "l": "ADP deaminase activity", "d": ["Catalysis of the reaction: ADP + H2O = IDP + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3240957", "l": "Formation of PRC2-EZH2 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23080", "l": "L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.90", "l": "\"L-rhamnonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48097", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75944", "l": "beta-alanine + L-arginine => 3-guanidinopropanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0015280", "l": "ligand-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}, {"i": "REACT:R-HSA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420117", "l": "VEGFR2 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980125", "l": "ITCH binds DTX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809521", "l": "BPIF binds bacteria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031433", "l": "telethonin binding", "d": ["Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47461", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA => (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10257", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050119", "l": "N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58008", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21799", "l": "dTDP-beta-L-rhamnose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46492", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047861", "l": "diiodotyrosine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18755", "l": "[protein]-disulfide + H(+) + NADPH => [protein]-dithiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58839", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74761", "l": "3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603419", "l": "Activated NTRK3 binds SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983700", "l": "SYK binds the activated BCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31256", "l": "(2S)-2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10565", "l": "H2O + oxaloacetate 4-methyl ester => H(+) + methanol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730840", "l": "Activation of RAC1 by VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50000", "l": "butane + H(+) + NADH + O2 = butan-1-ol + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.230", "l": "\"butane monooxygenase (soluble)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76639", "l": "cytosine(out) = cytosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65510", "l": "H2O2 + NH4(+) + pre-mycofactocin => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139909", "l": "Translocation of BMF to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29849", "l": "(3Z)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50695", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate <=> ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31967", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.112", "l": "\"ent-cassa-12,15-diene 11-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73534", "l": "CTP(out) + UTP(in) <=> CTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22435", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48599", "l": "1,2-didecanoylglycerol + H2O <=> decanoate + decanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66225", "l": "asc-C9-CoA + O2 => asc-DeltaC9-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73716", "l": "ATP(in) + dATP(out) => ATP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050656", "l": "3'-phosphoadenosine 5'-phosphosulfate binding", "d": ["Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67293", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810392", "l": "TMEM55B translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75955", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + oripavine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25262", "l": "2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65822", "l": "dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621573", "l": "CD209 activate GTPase RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71343", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) = chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65673", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656891", "l": "OPN1SW binds 11cRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168297", "l": "Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74223", "l": "H2O + L-seryl-tRNA(Ala) = L-serine + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827999", "l": "SOX17 binds the TET2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32287", "l": "(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate", "d": [], "t": []}, {"i": "EC:4.2.1.33", "l": "\"3-isopropylmalate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.19", "l": "\"phosphorylase kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17038", "l": "indole-3-ethanol + NADP(+) => H(+) + indole-3-acetaldehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031522", "l": "NR1H2,3 binds the APOE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60064", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443782", "l": "CHL1 interacts with contactin-6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49566", "l": "2-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532667", "l": "Removal of the second glucose by glucosidase II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.348834789597348", "identifiers": [{"i": "GO:0016846", "l": "carbon-sulfur lyase activity", "d": ["Catalysis of the elimination of hydrogen sulfide or substituted H2S."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50100", "l": "dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22252", "l": "a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.79", "l": "\"globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106368", "l": "(deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP."], "t": []}, {"i": "RHEA:62132", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23436", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807008", "l": "PTPRJ dephosphorylates MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23572", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisovalerophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847968", "l": "PTEN binds FRK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66464", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = scalarane-17alpha-19-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106419", "l": "NAD-dependent protein lipoamidase activity", "d": ["Catalysis of the reaction: (R)-N6-lipoyl-L-lysyl-[protein] + H2O + NAD+ = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:63640", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}, {"i": "EC:2.3.1.313", "l": "\"NAD-dependent lipoamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201685", "l": "Beta-catenin is released from the destruction complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77178", "l": "5-hydroxymethyl-dCMP + H(+) + H2O <=> 5-hydroxymethyl-dUMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44486", "l": "3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635918", "l": "Expression of CEBPB in response to stress (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13133", "l": "CTP + di-trans,poly-cis-dolichol = a dolichyl phosphate + CDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.108", "l": "\"dolichol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17490", "l": "H(+) + NADH + O2 + phthalate => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54193", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28129", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65060", "l": "NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55618", "l": "a carotenoid epsilon-end group => a carotenoid psi-end group", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047958", "l": "glycine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0016655", "l": "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule."], "t": []}, {"i": "EC:1.6.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240777", "l": "E2F1/2/3:DP1/2 binds EZH2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23944", "l": "(E)-coniferol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.111", "l": "\"coniferyl-alcohol glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60469", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37599", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.13", "l": "\"acyl-CoA 15-desaturase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18575", "l": "chelirubine + H2O2 => dihydrochelirubine + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19681", "l": "ATP + biotin + CoA = AMP + biotinyl-CoA + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.11", "l": "\"biotin--CoA ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76825", "l": "formaldehyde + H(+) + NADH + NH4(+) => H2O + methylamine + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378952", "l": "Thyrotropin is a heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55300", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77229", "l": "5'-deoxyadenosine + A + geneticin + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + gentamicin X2 + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45325", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218805", "l": "PKC autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.235", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805061", "l": "CK2 binds FACT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67419", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852716", "l": "Thrombin, ELANE cleave C5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070915", "l": "lysophosphatidic acid receptor activity", "d": ["Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52903", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide <=> 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69954", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44944", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64413", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-425861", "l": "Activation of Protein Kinase C novel isoforms (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36437", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(out) => a 1,2-diacyl-sn-glycero-3-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109857", "l": "MAP2K1 binds MAPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24038", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-phosphate + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3139027", "l": "Maturation of HIV Virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9621179", "l": "Cinaciguat binds sGC:NO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794344", "l": "HOMER binds SHANK proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65685", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57023", "l": "apulose + ATP <=> ADP + apulose 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69828", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54371", "l": "acetaldehyde + H(+) + pyruvate <=> acetoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74715", "l": "Autophosphorylation of insulin receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12127", "l": "4-coumaroyl-CoA + shikimate <=> CoA + trans-4-coumaroylshikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38376", "l": "bacterioruberin => bisanhydrobacterioruberin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27445", "l": "NADP(+) + xylitol = D-xylose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35859", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033904", "l": "dextranase activity", "d": ["Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51739", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102061", "l": "endo-beta-bergamotene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65470", "l": "CoA + propyl acetate => 1-propanol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071815", "l": "intermediate-density lipoprotein particle binding", "d": ["Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295613", "l": "SPRY2 binds GRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43466", "l": "(2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11939", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + trans-resveratrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102952", "l": "UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681980", "l": "ATG12 binds ATG7 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45209", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16490", "l": "(R)-prunasin + H2O => D-glucose + mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953013", "l": "E2F7 binds E2F8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39349", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781840", "l": "ERCC6 binds stalled RNA Pol II (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73434", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72997", "l": "L-fucose(in) + 2 Na(+)(in) => L-fucose(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66085", "l": "L-kynurenine + oxaloacetate => H2O + kynurenate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50738", "l": "a quinol + thiosulfate => a quinone + 2 H(+) + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798748", "l": "Exocytosis of secretory granule lumen proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944262", "l": "Association of procollagen type X (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71706", "l": "taurocholate(out) <=> taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404200", "l": "IGF1,2 binds IGF1R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14305", "l": "ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": [], "t": []}, {"i": "EC:6.1.1.15", "l": "\"proline--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794347", "l": "Homer1,2,3 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189062", "l": "lactose + H2O => D-glucose + D-galactose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018808", "l": "RAC3 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20404", "l": "a beta-lactam + H2O <=> a substituted beta-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61684", "l": "glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73182", "l": "S-adenosyl-L-methionine + scutellarein <=> H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44732", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391913", "l": "FPR2 binds FPR2 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654623", "l": "Activated FGFR3 binds FRS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866277", "l": "AP-2 directly binds some endocytic cargo (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051724", "l": "NAD transmembrane transporter activity", "d": ["Enables the transfer of NAD from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41087", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68193", "l": "decanoyl-CoA + phytol => CoA + decanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809793", "l": "MTMR2 binds SBF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225960", "l": "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60865", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52089", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12156", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.398", "l": "\"2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052624", "l": "2-phytyl-1,4-naphthoquinone methyltransferase activity", "d": ["Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69466", "l": "2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66932", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate = avenanthramide A + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912391", "l": "NICD1 is phosphorylated by CDK8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210881", "l": "Dimerization of Tie2/Ang1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39018", "l": "22-oxodocosanoate + H2O + NAD(+) <=> docosanedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57127", "l": "2-oxoglutaramate <=> 2-hydroxy-5-oxoproline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167419", "l": "The receptor:G-protein complex releases GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50462", "l": "a medium-chain fatty acyl-[ACP] + AMP + diphosphate => a medium chain fatty acid + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905055", "l": "calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28345", "l": "dITP + H2O <=> dIMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036429", "l": "adenosylcobinamide kinase (ATP-specific) activity", "d": ["Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.30", "l": "\"coccolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28999", "l": "H(+)(out) + homoserine lactone(in) = H(+)(in) + homoserine lactone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34044", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine => 5''-phosphoribostamycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14937", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928639", "l": "p-EFNB binds GRB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10533", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine => D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64629", "l": "acetyl-CoA + octan-1-ol => CoA + octyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57433", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] => 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28650", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate <=> 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-919404", "l": "Phosphorylated STAT5 is released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20678", "l": "alizarin + UDP-alpha-D-glucose => 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102944", "l": "medicagenate UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate = UDP(3-) + a medicagenate monoglucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72877", "l": "anthocyanin A9 + CoA => anthocyanin A7 + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23132", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": [], "t": []}, {"i": "EC:1.8.7.1", "l": "\"assimilatory sulfite reductase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156699", "l": "Inactivation of Wee1 kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10741", "l": "a secondary alcohol + NAD(+) => a ketone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428296", "l": "IGF2BP1 binds specific RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006507", "l": "GRIN2A gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55899", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 5-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13401", "l": "(2E,6E)-farnesol = (2Z,6E)-farnesol", "d": [], "t": []}, {"i": "EC:5.2.1.9", "l": "\"farnesol 2-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77429", "l": "(S)-mandelonitrile => benzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23539", "l": "alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430096", "l": "GP1b-IX-V binds filamin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45037", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine => 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18298", "l": "a phtalamide + H2O => a primary amine + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.4.-", "l": "\"Linked to decarboxylation\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333608", "l": "GSSebGalNac is reduced and methylated to MeSebGalNac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74859", "l": "dopamine + formaldehyde = H2O + norsalsolinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39278", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH <=> (15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371518", "l": "SIRT1 binds to HSF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102903", "l": "gamma-terpinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21841", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63092", "l": "H(+) + ilicicolin A + NADPH + O2 = H2O + ilicicolin A epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.132", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67535", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61076", "l": "(-)-minovincinine + acetyl-CoA = (-)-echitovenine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38603", "l": "NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32667", "l": "coenzyme M + methanethiol = H(+) + hydrogen sulfide + methyl-coenzyme M", "d": [], "t": []}, {"i": "EC:2.1.1.251", "l": "\"methylated-thiol--coenzyme M methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052731", "l": "phosphocholine phosphatase activity", "d": ["Catalysis of the reaction: choline phosphate + H2O = choline + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50138", "l": "(9Z)-octadecenoate + ethanol + H(+) => ethyl (9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29733", "l": "beta-maltose(out) => beta-maltose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54120", "l": "coelenterazine h + O2 = coelenterazine h dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34540", "l": "S-adenosyl-L-methionine + tellurite => methanetellurite + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61234", "l": "(S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-isoleucine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72676", "l": "3',5'-cyclic CMP + H2O => CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654573", "l": "Activated FGFR1 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835121", "l": "Heparin binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044540", "l": "L-cystine L-cysteine-lyase (deaminating)", "d": ["Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102981", "l": "4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP = (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54667", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene <=> pre-alpha-onocerin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445084", "l": "Phosphorylation of L1 by SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672817", "l": "Active MTORC1 binds the ULK1 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0048407", "l": "platelet-derived growth factor binding", "d": ["Binding to platelet-derived growth factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381109", "l": "IRE1 binds IRE1 forming dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75244", "l": "FASL binds FAS Receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21511", "l": "all-trans-retinyl hexadecanoate + H2O <=> H(+) + hexadecanoate + retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42781", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052655", "l": "L-valine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62238", "l": "a cytidine dimer in DNA + H(+) => a cytidine(6-4)cytidine in DNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49526", "l": "a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10633", "l": "D-mannonate + NAD(+) => D-mannuronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682992", "l": "KDM4A,B bind H4K20Me2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33220", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16885", "l": "2 bilirubin-glucuronoside = bilirubin IXalpha + bilirubin-bisglucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61891", "l": "diosgenin + UDP-alpha-D-glucose <=> diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29113", "l": "NADP(+) + ubiquinol-8 => H(+) + NADPH + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35248", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54289", "l": "ATP + L-tyrosyl-[protein] => diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033410", "l": "UAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008294", "l": "calcium- and calmodulin-responsive adenylate cyclase activity", "d": ["Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17031", "l": "allantoate + H(+) => (S)-allantoin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373745", "l": "SDK1 homophillic interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41573", "l": "lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62416", "l": "(E)-4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17504", "l": "H2O + polyneuridine aldehyde <=> 16-epivellosimine + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46967", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51970", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70225", "l": "2-oxobutanoate + L-glutamate => (2S)-2-aminobutanoate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47567", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912467", "l": "BRCA1 is recruited to unsynapsed regions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73709", "l": "ATP(out) + UDP(in) => ATP(in) + UDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683964", "l": "ATM phosphorylates EYA1-4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199093", "l": "CXADR binds to AMICA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57957", "l": "dimethyl sulfoxide + H(+) + NADH + O2 => dimethyl sulfone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22234", "l": "diphosphate + NADP(+) + squalene => H(+) + NADPH + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65359", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54865", "l": "H(+) + NADPH + O2 + sulcatone => 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16307", "l": "3-hydroxy-3-methylglutarate + CoA + H(+) => (3S)-hydroxy-3-methylglutaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102734", "l": "brassinolide synthase activity", "d": ["Catalysis of the reaction: H+ + castasterone + NADPH + O2 = brassinolide + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30044", "l": "fumarate + L-aspartate => iminosuccinate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64283", "l": "(S)-1-phenylethylamine + pyruvate <=> acetophenone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74002", "l": "dimethylallyl diphosphate + quinolinone B <=> diphosphate + peniprequinolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37299", "l": "H2O + L-alanyl-L-threonine = L-alanine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44470", "l": "a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47494", "l": "isodeoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874685", "l": "CBL binds MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31664", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013023", "l": "RHOB GEFs activate RHOB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46879", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate <=> [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003974", "l": "UDP-N-acetylglucosamine 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351901", "l": "Caspase-mediated cleavage of MST3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679266", "l": "Beclin-1 complex translocates to the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604368", "l": "Autocatalytic activation of bound proMMP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0019957", "l": "C-C chemokine binding", "d": ["Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46201", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58867", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25780", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": [], "t": []}, {"i": "EC:1.1.1.336", "l": "\"UDP-N-acetyl-D-mannosamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70345", "l": "3-chloro-L-tyrosine + NADPH => chloride + L-tyrosine + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54148", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene = 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55450", "l": "a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19692", "l": "L-rhamnulose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21385", "l": "L-phenylalanine => (E)-cinnamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77267", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol = 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63140", "l": "H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14420", "l": "acetyl phosphate + L-lysine <=> H(+) + N(6)-acetyl-L-lysine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625520", "l": "MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72319", "l": "n chloride(in) + urate(out) = n chloride(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14774", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine => corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67475", "l": "H2O + succinyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862300", "l": "LYZ binds bacterial peptidoglycan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36659", "l": "carbamoyl phosphate + descarbamoylnovobiocin = novobiocin + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.12", "l": "\"decarbamoylnovobiocin carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12586", "l": "16,17-didehydroprogesterone + H2O => 16alpha-hydroxyprogesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396370", "l": "VTN binds collagens II, III and V (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40510", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51004", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] = an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62778", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49620", "l": "D-erythritol 1-phosphate + NADP(+) = D-erythrulose 1-phosphate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.402", "l": "\"D-erythritol 1-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38386", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23067", "l": "an alkanesulfonate + FMNH2 + O2 <=> an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9633044", "l": "ESR binds STRN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15038", "l": "putrescine + S-adenosyl-L-methionine => H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70710", "l": "6-sulfo-beta-D-quinovose <=> 6-sulfo-D-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49212", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814831", "l": "TBC1D20 binds RAB1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793451", "l": "MLKL binds ITCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0030515", "l": "snoRNA binding", "d": ["Binding to a small nucleolar RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16759", "l": "H(+) + NADPH + trypanothione disulfide => NADP(+) + trypanothione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77293", "l": "1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10590", "l": "4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase] => 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177934", "l": "EGFR autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57394", "l": "3-O-acetyl-4'-O-demethylpapaveroxine + H(+) => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372697", "l": "Crk binding to p130cas (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71963", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45575", "l": "[(1->4)-beta-D-mannuronosyl](n) <=> [alginate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77081", "l": "Formation of the CE:GMP intermediate complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696947", "l": "USP47 deubiquitinates POLB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070379", "l": "high mobility group box 1 binding", "d": ["Binding to high mobility group box 1 (HMBGB1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5612510", "l": "Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56413", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61443", "l": "acetyl-CoA + S-(2-succino)-L-cysteine <=> CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69685", "l": "CHEK2 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210426", "l": "Glutamate synaptic vesicle docking and priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782381", "l": "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354066", "l": "Translocation of PTK2 to Focal complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76327", "l": "L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21356", "l": "L-arabinitol + NAD(+) = H(+) + L-ribulose + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.13", "l": "\"L-arabinitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39680", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016738", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen."], "t": []}, {"i": "EC:1.19.6.-", "l": "\"With dinitrogen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38874", "l": "uridine(2457) in 23S rRNA <=> pseudouridine(2457) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371435", "l": "Constitutive phosphorylation by GSK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030169", "l": "low-density lipoprotein particle binding", "d": ["Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73426", "l": "L-asparagine(out) <=> L-asparagine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50793", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45934", "l": "4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31059", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole-4-acetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32022", "l": "(2E,6E)-farnesyl diphosphate <=> beta-cubebene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46093", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163554", "l": "Phosphorylated HSL dimer translocates from the cytosol to the lipid particle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018684", "l": "2,5-diketocamphane 1,2-monooxygenase", "d": ["Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50914", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004106", "l": "chorismate mutase activity", "d": ["Catalysis of the reaction: chorismate = prephenate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37000", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15924", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11544", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": [], "t": []}, {"i": "EC:3.5.1.26", "l": "\"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54674", "l": "(+)-kolavelool + diphosphate => (+)-kolavenyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25628", "l": "H2O + histamine + O2 <=> H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.417", "l": "\"3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57921", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) => H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034768", "l": "(E)-beta-ocimene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25394", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) <=> cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71852", "l": "glycocholate(out) => glycocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13976", "l": "diphosphate + H(+)(in) + H2O <=> 2 H(+)(out) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58231", "l": "L-asparaginyl-[protein] + NAD(+) <=> H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65884", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = H2O + L-glutamate + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70077", "l": "A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49513", "l": "2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylisomalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46836", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28008", "l": "formaldehyde + H2O2 + L-tryptophan => H2O + N(alpha)-methyl-L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878654", "l": "ACP6 hydrolyses MYS-LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654399", "l": "Activated FGFR2 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209167", "l": "Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35512", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805205", "l": "GPR35 binds kynurenic acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23702", "l": "(6R)-10-formyltetrahydrofolate + H(+) => (6R)-5,10-methenyltetrahydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73520", "l": "dUTP(out) + UTP(in) => dUTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33686", "l": "H(+) + L-serine + octadecanoyl-CoA <=> 3-oxoeicosasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24991", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854052", "l": "Formation of the SCF-FBXL7 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47055", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854462", "l": "VLDLR binds VLDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944236", "l": "Association of procollagen type XIV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12348", "l": "(S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": [], "t": []}, {"i": "EC:5.3.3.4", "l": "\"muconolactone Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46043", "l": "2'-deoxycytidine + ATP <=> ADP + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46674", "l": "5beta-dihydroaldosterone + NADP(+) => aldosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870469", "l": "RGGT geranylgeranylates RAB proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40965", "l": "2 2-aminophenoxazin-3-one + 6 H2O => 4 2-aminophenol + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28127", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose => alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728747", "l": "GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852716", "l": "Thrombin, ELANE cleave C5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30073", "l": "acetate + butanoyl-CoA => acetyl-CoA + butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27478", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + neopinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102597", "l": "3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity", "d": ["Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 = oryzalexin E + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23645", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32364", "l": "L-gulono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13660", "l": "acetyl-[citrate lyase ACP] + H2O <=> acetate + H(+) + holo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77462", "l": "3-formylthiophene + hydrogen cyanide <=> (2S)-2-hydroxy-2-(thiophen-3-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983153", "l": "E1 mediated ubiquitin activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45980", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665034", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12025", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline => D-glucose + O-sinapoylcholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46785", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25213", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102126", "l": "coniferyl aldehyde 5-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 = 5-hydroxy-coniferaldehyde + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404144", "l": "Parenchymal atROL translocates to HSCs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (6E,10E)-geranyllinalool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56203", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193669", "l": "TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14549", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.9", "l": "\"2-hydroxymuconate-6-semialdehyde hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41719", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033265", "l": "choline binding", "d": ["Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28835", "l": "citrate(out) + succinate(in) = citrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866277", "l": "AP-2 directly binds some endocytic cargo (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.24", "l": "\"tocopherol cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22508", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835940", "l": "HCMV TRS1 binds PKR dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71093", "l": "dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983150", "l": "Proteasomal cleavage of substrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52265", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine => gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74823", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046539", "l": "histamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507871", "l": "Aquaporins passively transport glycerol out of cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050592", "l": "4-hydroxyphenylacetaldehyde oxime monooxygenase activity", "d": ["Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H+ + NADPH + O2 = (S)-4-hydroxymandelonitrile + 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140292", "l": "ADP-ribosylserine hydrolase activity", "d": ["Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033412", "l": "UAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39507", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15188", "l": "L-arginine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67914", "l": "1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197698", "l": "Src phosphorylate WASP,N-WASP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858428", "l": "FCAMR binds IgA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685603", "l": "SAP and EAT2 binds SLAMF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.95", "l": "\"snake venom factor V activator\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120022", "l": "glucagon family peptide binding", "d": ["Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68929", "l": "ATP + H(+) + heptanoate + NADPH => AMP + diphosphate + heptanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39998", "l": "an N-acylethanolamine + H2O <=> a fatty acid + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39802", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016996", "l": "endo-alpha-(2,8)-sialidase activity", "d": ["Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.21", "l": "\"inositol-hexakisphosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50344", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH = 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.252", "l": "\"mycolipanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68140", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH = (2R,5R)-hexanediol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.6", "l": "\"aureusidin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30641", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102750", "l": "tetrahydrogeranylgeranyl-chlorophyll a reductase activity", "d": ["Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36787", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.40", "l": "\"UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40782", "l": "2-aminopentanenitrile + H(+) + 2 H2O <=> L-2-aminopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390438", "l": "FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690669", "l": "CD22 binds itself to form homo-oligomers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41837", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64417", "l": "D-xylofuranose + NADP(+) => D-xylono-1,4-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31770", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044729", "l": "hemi-methylated DNA-binding", "d": ["Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604722", "l": "Activation of proMMP9 by proteases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607747", "l": "TRAF6 binds MALT1 oligomers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002401", "l": "Association of procollagen type XVIII (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10133", "l": "ATP + benzoate + CoA => AMP + benzoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47938", "l": "4-hydroxybenzoate + 2 H(+) + NADPH => 4-hydroxybenzaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692749", "l": "CDC14A,B bind MAPK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022870", "l": "protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52921", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20791", "l": "NAD(+) + phosphate <=> ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-350598", "l": "Arginine<=>Agmatine+CO2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12187", "l": "(S,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71809", "l": "an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide => a 2'-deoxyguanosine in DNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52551", "l": "L-threonate + NAD(+) <=> 2-dehydro-L-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611839", "l": "β3-agonists bind ADRB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610723", "l": "GLI proteins bind SUFU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77005", "l": "H2O + L-enduracididine => (4S)-4-hydroxy-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661517", "l": "LUBAC binds OTULIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.47", "l": "\"dapdiamide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34393", "l": "[beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51627", "l": "formate + GTP + H(+) <=> CO2 + dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20491", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66012", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730843", "l": "Phosphorylation of LAT by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71559", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O = 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16226", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O => N-(6-aminohexanoyl)-6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238694", "l": "PORCN palmitoleoylates N-glycosyl WNTs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.4.1", "l": "\"protein disulfide-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17916", "l": "H2O + NAD(+) + nitrite <=> H(+) + NADH + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42022", "l": "H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone => 11-dehydrocorticosterone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805740", "l": "SETD8 methylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.359", "l": "\"aldose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55238", "l": "(9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61849", "l": "cholesterol + UDP-alpha-D-glucose => cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718020", "l": "PTGFR binds PTGFR agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56858", "l": "a carboxylate + AH2 + H(+) => A + an aldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.284", "l": "\"3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613497", "l": "Unwinding DNA for the nascent transcript (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692809", "l": "CDC42 binds effectors at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71956", "l": "glutarate(out) + 3 Na(+)(out) => glutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54515", "l": "peregrinol diphosphate <=> (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15670", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64596", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.370", "l": "\"inositol phosphorylceramide mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018747", "l": "RHOQ GEFs activate RHOQ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38357", "l": "(E)-cinnamoyl-CoA + H2O => (R)-3-phenyllactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388900", "l": "Neurotensin receptors can bind neurotensins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0106029", "l": "tRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."], "t": []}, {"i": "RHEA:54572", "l": "a uridine in tRNA = a pseudouridine in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849908", "l": "SALM4 binds flotillin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668735", "l": "RAC1:GTP binds NOX3 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016263", "l": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "d": ["Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50350", "l": "a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070042", "l": "rRNA (uridine-N3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623415", "l": "FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76884", "l": "3-aminobutan-1-ol + H2O + NAD(+) => 4-hydroxybutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700175", "l": "Active ALK phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20708", "l": "ATP + erythritol = ADP + D-erythritol 4-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.27", "l": "\"erythritol kinase (D-erythritol 4-phosphate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768782", "l": "miR-224 represses NPAS4 mRNA translation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21920", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034565", "l": "1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity", "d": ["Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672948", "l": "MARK3 phosphorylates KSR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23416", "l": "(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.71", "l": "\"2-phosphosulfolactate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32142", "l": "ATP + CoA + malonate <=> AMP + diphosphate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9676264", "l": "Formation of the SET1B complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26267", "l": "dehydroabietate + 2 H(+) + NADPH => dehydroabietadienal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47490", "l": "isodeoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020504", "l": "MECP2 binds GRIN2B gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63876", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 = (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.75", "l": "\"3(1)-hydroxy-L-isoleucine 4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31186", "l": "acetyl-CoA + decanoyl-CoA <=> 3-oxododecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58724", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651280", "l": "RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59372", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16229", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.41", "l": "\"phosphatidate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050616", "l": "secologanin synthase activity", "d": ["Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004508", "l": "steroid 17-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67197", "l": "H2O + N-acetylserotonin => acetate + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58059", "l": "hypotaurine + pyruvate <=> 2-sulfinoacetaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69756", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 => (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69188", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34461", "l": "diphosphate + sclareol => 8-hydroxycopalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34547", "l": "ATP + cob(II)yrinate + H2O + L-glutamine = ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54894", "l": "[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20945", "l": "S-adenosyl-L-methionine + theobromine => caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43208", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.229", "l": "\"tRNA (carboxymethyluridine(34)-5-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450474", "l": "MK2 phosphorylates BRF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500781", "l": "Fgd1 reactivates F420 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15416", "l": "(2R,3R)-tartrate <=> H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74025", "l": "L-alanine(out) + L-serine(in) => L-alanine(in) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44475", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51476", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) = a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.1.98.6", "l": "\"ribonucleoside-triphosphate reductase (formate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49809", "l": "a quinone + butan-1-ol => a quinol + butanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55552", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703895", "l": "CASR binds CASR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34309", "l": "2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrocatechol + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912629", "l": "CBL is tyrosine phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677051", "l": "Formation of the PCAF-ATAC complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470010", "l": "Dimerization of STATs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018482", "l": "4-formylbenzenesulfonate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-formylbenzenesulfonate + H2O + NAD+ = 4-sulfobenzoate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41030", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14478", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034902", "l": "endosulfan sulfate hydrolase activity", "d": ["Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49598", "l": "H(+) + N-acyl-D-galactosylsphing-4-enine + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46628", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63731", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan-2-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65363", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102429", "l": "genistein-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: genistin + UDP-alpha-D-glucose = genistin 7-gentiobioside + UDP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69875", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59775", "l": "D-sorbitol + O2 <=> D-sorbopyranose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32489", "l": "CMP + 2 H(+) + phosphocholine => CDP-choline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67075", "l": "a very long-chain fatty acyl-CoA + H2O <=> a very long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18259", "l": "2 CO2 + 2 H2O + protoporphyrinogen IX => coproporphyrinogen III + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638209", "l": "Defective SLC2A9 does not transport Fru, Glc, urate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66273", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40230", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 <=> A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446322", "l": "PARVA associates with Paxillin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022065", "l": "DSPGs are secreted (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35805", "l": "7,8-dihydroneopterin 2'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013009", "l": "RHOA binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31950", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5225649", "l": "RBBP7 binds histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602454", "l": "proMMP9 binds TIMP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014449", "l": "RHOG binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654159", "l": "Activated FGFR2 binds PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12158", "l": "2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692764", "l": "MAPK6 binds CCND3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46211", "l": "ATP + CoA + eicosanoate <=> AMP + diphosphate + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53306", "l": "A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate => AH2 + 2 ATP + 2 cob(II)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67399", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56213", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77608", "l": "Binding of A1CF to stem-looped RNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41002", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17203", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-L-arabinonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56324", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] = 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:2.1.1.n11", "l": "\"methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40960", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050225", "l": "pseudouridine kinase activity", "d": ["Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H+ + pseudouridine 5'-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9035484", "l": "CysS248-MPST:TXN2 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58080", "l": "1-docosanoylglycerol + H2O = docosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34388", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51145", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 => (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033520", "l": "TYSND1 cleaves TYSND1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24808", "l": "(2S)-2-acetolactate + thiamine diphosphate <=> 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68554", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45344", "l": "a globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside NORint (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27394", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209296", "l": "SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72532", "l": "ATP + H2O + methyl beta-D-galactoside(out) => ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56096", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) = [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10091", "l": "sucrose + UDP-alpha-D-galactose <=> 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69418", "l": "H2O + hypothiocyanous acid => H(+) + H2O2 + thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31669", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37684", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28406", "l": "H2O + XTP = H(+) + phosphate + XDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212642", "l": "L-Glutamine transport into neurons (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75081", "l": "Formation of AT-AC B Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38079", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32596", "l": "7-isopropyl-4-methyloxepan-2-one + H2O => 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380241", "l": "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58643", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021357", "l": "PRKCI phosphorylates ELF3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004781", "l": "sulfate adenylyltransferase (ATP) activity", "d": ["Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32378", "l": "limonene-1,2-diol + NAD(+) <=> 1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015272", "l": "ATP-activated inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force."], "t": []}, {"i": "REACT:R-HSA-5683209", "l": "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM). (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53630", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707659", "l": "Hemes:LY96 activates TLR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60731", "l": "citral + H2O + NADP(+) <=> 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75571", "l": "acetyl-CoA + cyathin A3 = 11-O-acetylcyathin A3 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798031", "l": "TP53 stimulates BTG2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47652", "l": "D-ribitol 1-phosphate + H2O = phosphate + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29134", "l": "menaquinol-8 + nitrate <=> H2O + menaquinone-8 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15482", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O => (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254251", "l": "ERBB4s80 binds YAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51421", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24573", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose => [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507871", "l": "Aquaporins passively transport glycerol out of cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050648", "l": "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30739", "l": "1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45159", "l": "3-oxopropanoyl-CoA + H2O <=> 3-oxopropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16056", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine <=> H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63931", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17300", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45631", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] <=> holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0046592", "l": "polyamine oxidase activity", "d": ["Catalysis of the oxidative degradation or interconversion of polyamines."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74726", "l": "isorhamnetin + S-adenosyl-L-methionine <=> 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60451", "l": "an S-substituted glutathione + H2O <=> glycine + S-substituted gamma-glutamyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45924", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791133", "l": "Expression of Sec31A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49280", "l": "FADH2 + O2 + phenol = catechol + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.20", "l": "\"phenol 2-monooxygenase (FADH2)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912627", "l": "CBL ubiquitinates PI3K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48492", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44821", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42493", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 => 3'-N-debenzoyltaxol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54836", "l": "H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27646", "l": "inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448678", "l": "CTSG cleaves CASP1(1-404) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57397", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine => 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30158", "l": "FADH2 + 2 Fe(3+) <=> FAD + 2 Fe(2+) + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19268", "l": "carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021357", "l": "PRKCI phosphorylates ELF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31563", "l": "H2O + leukotriene C4 = L-glutamate + leukotriene D4", "d": [], "t": []}, {"i": "EC:3.4.19.14", "l": "\"leukotriene-C4 hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12413", "l": "(2R)-3-phosphoglycerate + H2O => (R)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031544", "l": "peptidyl-proline 3-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032781", "l": "WWTR1 (TAZ) binds TEAD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847977", "l": "FRK phosphorylates PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28702", "l": "Mn(2+)(in) <=> Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77511", "l": "2-methoxybenzaldehyde + hydrogen cyanide = (2S)-2-hydroxy-2-(2-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40770", "l": "(20S)-ginsenoside R1 + H2O <=> (20S)-ginsenoside Rg1 + D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010681", "l": "PKC phosphorylates ROBO3.1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13457", "l": "3-methyl-2-oxobutanoate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] = CO2 + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]", "d": [], "t": []}, {"i": "EC:1.2.4.4", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41223", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062064", "l": "box C/D snoRNP complex binding", "d": ["Binding to a box C/D snoRNP complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75619", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = ectocarpin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74805", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668545", "l": "NIK autophosphorylates on T559 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39608", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10210", "l": "H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761900", "l": "HBV X protein binds SQSTM1 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63788", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900765", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54704", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990882", "l": "CDK1 phosphorylates NUP98 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432054", "l": "Aquaporin-1 passively transports water out of cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37070", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19135", "l": "3,5,3'-triiodothyropyruvate + L-glutamate => 2-oxoglutarate + 3,3',5-triiodo-L-thyronine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35592", "l": "H2 + n sulfur => H(+) + hydrogen sulfide + (n-1) sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170011", "l": "stalled ribosome sensor activity", "d": ["A molecule that recognizes stalled ribosomes and initiates a signaling response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140863", "l": "histone H2AK127 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-127 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56736", "l": "H2O + O2 + retinal = H(+) + H2O2 + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237160", "l": "MTA is cleaved and phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706287", "l": "Active FLT3 binds to ABL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875523", "l": "MET binds TNS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.7", "l": "\"mannokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54937", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH => decanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33001", "l": "(+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44025", "l": "(3R)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938930", "l": "RUNX1 binds ELF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37308", "l": "glycyl-L-asparagine + H2O => glycine + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19613", "l": "dimethyl sulfide + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + trimethylsulfonium", "d": [], "t": []}, {"i": "EC:2.1.1.96", "l": "\"thioether S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35856", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050409", "l": "indolylacetylinositol arabinosyltransferase activity", "d": ["Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23283", "l": "acetyl-CoA + cysteamine <=> CoA + S-acetylcysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877192", "l": "RUNX1 binds FOXP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45426", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.15", "l": "\"nitrite reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25926", "l": "8-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-8-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69458", "l": "3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+) => 3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734713", "l": "ORC6 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58838", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983156", "l": "Polyubiquitination of substrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036434", "l": "nitronate monooxygenase (FMN-linked) activity", "d": ["Catalysis of the reaction: ethylnitronate + FMNH(2) + O2 = acetaldehyde + FMN + H2O + H+ + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0022848", "l": "acetylcholine-gated monoatomic cation-selective channel activity", "d": ["Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24353", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29548", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75891", "l": "Abortive Initiation After Second Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71646", "l": "guanosine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9017491", "l": "RHOJ GEFs activate RHOJ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34185", "l": "alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008886", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H2O + NADP+ = 3-phospho-D-glycerate + 2 H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16991", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679775", "l": "COMT binds COMT Inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41851", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40043", "l": "ATP + citrate + L-glutamate = ADP + beta-citrylglutamate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.17", "l": "\"beta-citrylglutamate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10535", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine <=> D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52275", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine <=> gramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016629", "l": "12-oxophytodienoate reductase activity", "d": ["Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48594", "l": "a quinol + CO2 => a quinone + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52139", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40475", "l": "1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13959", "l": "6 H(+) + 2 hydrogen sulfide + 2 sulfite => 4 H2O + O2 + 4 sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432148", "l": "Fgr may phosphorylate p38 MAPK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38095", "l": "gamma-tocotrienol + S-adenosyl-L-methionine = alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15983", "l": "CO2 + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44828", "l": "(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399711", "l": "Activation of Ca impermeable AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13815", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => benzene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788999", "l": "HV1-mediated H+ transfer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36721", "l": "CoA + H(+) + N-hexacosenoylsphinganine => hexacosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41288", "l": "H2O + N-tetradecanoylsphing-4-enine => sphing-4-enine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25983", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103104", "l": "6-methylthiohexyldesulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate = adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61967", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000074", "l": "TCN2 binds RCbl in the circulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362522", "l": "ALDHs oxidise atRAL to atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698016", "l": "PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749590", "l": "ASA- acetylates ALB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73051", "l": "hydrogencarbonate(in) + taurocholate(out) = hydrogencarbonate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34192", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43276", "l": "a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GalNAc-GD1a + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29579", "l": "Fe(2+)(in) + H(+)(in) = Fe(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20667", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-glucitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57606", "l": "a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-874087", "l": "SGT1 binds HSP90 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37568", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631065", "l": "Substrate translocates into late endosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15564", "l": "S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47399", "l": "H2O + octadecanoate ester <=> an aliphatic alcohol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696605", "l": "USP12, USP26 deubiquitinate AR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662986", "l": "MT2A binds copper (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28025", "l": "ATP + holo-[ACP] + octanoate <=> AMP + diphosphate + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21853", "l": "(R)-10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102038", "l": "4-nitrobenzyl alcohol oxidase activity", "d": ["Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26236", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75761", "l": "10-hydroxy-(11E)-octadecenoate => (9Z,11E)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53051", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate <=> 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46826", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17726", "l": "(2S,3S)-2-methylcitrate => 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28963", "l": "H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70475", "l": "2 S-adenosyl-L-methionine + sphing-4-enine = 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0016889", "l": "DNA endonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters."], "t": []}, {"i": "EC:3.1.22.-", "l": "\"Endodeoxyribonucleases producing other than 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34432", "l": "(+)-secoisolariciresinol + NADP(+) => (-)-lariciresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58820", "l": "H(+) + malonate + Na(+)(in) = acetate + CO2 + Na(+)(out)", "d": [], "t": []}, {"i": "EC:7.2.4.4", "l": "\"biotin-dependent malonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71637", "l": "phosphate(out) + 2 thiosulfate(in) => phosphate(in) + 2 thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047761", "l": "butyrate kinase activity", "d": ["Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53878", "l": "ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate => a cytidine in tRNA + acetyl-CoA + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69331", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27605", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate <=> di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805981", "l": "HMGB1 release from cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36982", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50649", "l": "2-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928578", "l": "EPH receptors autophosphorylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047648", "l": "alkylamidase activity", "d": ["Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylammonium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806392", "l": "TP53 stimulates MLH1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682967", "l": "WHSC1 binds DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36106", "l": "anthranilate + S-adenosyl-L-methionine <=> O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296309", "l": "HCAR3 binds HCAR3 ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448963", "l": "Interaction of MyoD:E protein with MEF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31983", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35132", "l": "H(+)(out) + L-alanyl-L-glutamate(out) => H(+)(in) + L-alanyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51811", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35812", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (-)-medicarpin + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691214", "l": "NOTCH1 HD domain mutants bind JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40624", "l": "H2O + tritetradecanoylglycerol => 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352956", "l": "glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35862", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70355", "l": "1-carboxybiuret + H(+) = biuret + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645481", "l": "TIFA oligomerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72501", "l": "2-oxoglutarate(out) + prostaglandin E2(in) => 2-oxoglutarate(in) + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77068", "l": "Activation of GT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004088", "l": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48745", "l": "(-)-yatein + 2-oxoglutarate + O2 => (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685681", "l": "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725855", "l": "NR3C2 binds NR3C2 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161538", "l": "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9844860", "l": "ST3GAL5 transfers NeuNAc to ceramides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72725", "l": "UDP-alpha-D-xylose(out) + UMP(in) => UDP-alpha-D-xylose(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42042", "l": "a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+) => a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21644", "l": "ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.30", "l": "\"glycerol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12080", "l": "acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.180", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase III\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052874", "l": "FMN reductase (NADH) activity", "d": ["Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18728", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA <=> acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25605", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O = 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027625", "l": "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72391", "l": "2 hydrogencarbonate(out) + oxalate(in) = 2 hydrogencarbonate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44611", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42834", "l": "(S)-3-acetyloctanal + CO2 => (2E)-octenal + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14294", "l": "D-glucose + NAD(+) => D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218906", "l": "RIPK3 phosphorylates MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166214", "l": "FA anion flip-flops to the opposite surface (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34026", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31500", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983285", "l": "RAD51B binds RAD51C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72347", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole = 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59653", "l": "D-xylotetraono-1,5-lactone + H2O => D-xylotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662620", "l": "MT3 binds cadmium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693593", "l": "D-loop extension by DNA polymerases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26239", "l": "(2E,6E,10E)-geranylgeraniol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22277", "l": "2-oxoaldehyde + H2O + NAD(+) => a 2-oxocarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51325", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730862", "l": "Autophosphorylation of LYN kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57785", "l": "1,4-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56022", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12897", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.137", "l": "\"(+)-abscisic acid 8'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37284", "l": "H2O + L-alanyl-L-histidine => L-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983307", "l": "IL15 binds IL15RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12813", "l": "L-glutamate = D-glutamate", "d": [], "t": []}, {"i": "EC:5.1.1.3", "l": "\"glutamate racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20475", "l": "AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] => (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74742", "l": "Phosphorylation of SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732629", "l": "PPARG binds PPARG agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49876", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21085", "l": "chondroitin 4'-sulfate => dermatan 4'-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12739", "l": "[PrdC protein]-L-selenocysteine/L-cysteine + D-proline => 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13604", "l": "cis-4-hydroxy-L-proline + NAD(+) <=> 4-oxo-L-proline + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619803", "l": "p-S516-ARHGEF7 activates RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912393", "l": "MAML in complex with NICD1 recruits CDK8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24198", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030957", "l": "Tat protein binding", "d": ["Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60204", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098605", "l": "selenocystathionine beta-synthase activity", "d": ["Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O."], "t": []}, {"i": "REACT:R-HSA-2408559", "l": "SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29624", "l": "alpha-maltopentaose + beta-maltose => alpha-maltohexaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40004", "l": "ent-copalyl diphosphate => (Z)-biformene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209057", "l": "Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110212", "l": "NTHL1 glycosylase mediated recognition and binding of dihydrouracil (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63898", "l": "isoaspulvinone E => aspulvinone E + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73813", "l": "L-proline(out) => L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36239", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76222", "l": "GDP(in) <=> GDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39239", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH = NADP(+) + triacontanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983285", "l": "RAD51B binds RAD51C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68717", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73679", "l": "3'-AMP(in) + ADP(out) + H(+)(out) = 3'-AMP(out) + ADP(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52043", "l": "L-cystine <=> 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55692", "l": "an inositol-1-phosphoceramide + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62882", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665032", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173769", "l": "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.4", "l": "\"fructokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42438", "l": "L-ascorbate 6-phosphate(in) + L-histidyl-[protein] => L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047097", "l": "phylloquinone monooxygenase (2,3-epoxidizing) activity", "d": ["Catalysis of the reaction: AH(2) + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424484", "l": "Phosphorylation of BTK by p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56085", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O => [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34351", "l": "(2E)-geranial + H2O + NAD(+) = geranate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.86", "l": "\"geranial dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483142", "l": "PC is transphosphatidylated to PG by PLD1-4/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018573", "l": "NOTCH3 binds activated EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62598", "l": "(6E)-8-oxogeranial + H(+) + NADH => (S)-8-oxocitronellyl enol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33236", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 => 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31706", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18446", "l": "H2O + IMP => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26438", "l": "3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.298", "l": "\"3-hydroxypropionate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0005550", "l": "pheromone binding", "d": ["Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39027", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035755", "l": "cardiolipin hydrolase activity", "d": ["Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA)."], "t": []}, {"i": "REACT:R-HSA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57002", "l": "CoA + H(+) + N(beta)-acetylstreptothricin F => acetyl-CoA + streptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16458", "l": "(2R,3S)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62143", "l": "dTMP + GTP <=> dTDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706344", "l": "FLT3 phosphorylates GRB10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419841", "l": "Light stimulates opsin receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44916", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH = (3E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706308", "l": "Active FLT3 binds to GRB10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626039", "l": "pGFAP binds GFAP in LAMP2a multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0050497", "l": "alkylthioltransferase activity", "d": ["Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.8.4.-", "l": "\"Transferring alkylthio groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665748", "l": "FMNL2 binds RHOC:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.43", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090079", "l": "GLB1 hydrolyses linker chain(2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54266", "l": "(3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69110", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987214", "l": "p-STAT3 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63384", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10690", "l": "phosphate + streptomycin => H2O + streptomycin 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684836", "l": "CLEC1B dimer binds PDPN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034798", "l": "fosfomycin 2-L-cysteine ligase activity", "d": ["Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19565", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + sabinene hydrate", "d": [], "t": []}, {"i": "EC:4.2.3.11", "l": "\"sabinene-hydrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13460", "l": "3-methyl-2-oxobutanoate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] <=> CO2 + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11179", "l": "kojibiose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71962", "l": "3 Na(+)(out) + oxaloacetate(out) <=> 3 Na(+)(in) + oxaloacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174967", "l": "NAT2 acetylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877192", "l": "RUNX1 binds FOXP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10703", "l": "H2O + limonene 1,2-epoxide <=> limonene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018810", "l": "trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity", "d": ["Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36224", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47847", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39012", "l": "a triacyl-sn-glycerol(in) => a triacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74288", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56068", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21163", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate <=> ATP + citrate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51190", "l": "peroxynitrite => nitric oxide + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031769", "l": "glucagon receptor binding", "d": ["Binding to a glucagon receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46677", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) => (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42718", "l": "(2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74726", "l": "Dissociation of insulin from insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851127", "l": "NPM1-ALK-dependent repression of pRB phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791016", "l": "SFTPB binds itself (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865280", "l": "TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814096", "l": "ARL1:GTP binds SCOC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61332", "l": "ATP + H2O + indoxyl sulfate(in) = ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45606", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-glucaro-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43397", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389919", "l": "Grb2 binds pBTLA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804955", "l": "ATM phosphorylates MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430135", "l": "p-SLP-76 binds ADAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21695", "l": "CDP-glycerol + H2O <=> CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141159", "l": "TNF-mediated dimerization of procaspase-8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617652", "l": "HOXD3 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014454", "l": "RHOG translocates to the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65074", "l": "dauca-4,7-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58895", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 <=> adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63968", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = atromentin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517674", "l": "p-S158,221-HuR binds mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811427", "l": "COPI vesicle uncoating at the ER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060241", "l": "lysozyme inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of lysozyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70692", "l": "ornithine => putrescine + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47267", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA <=> AMP + diphosphate + pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187293", "l": "SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28567", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP => 6 AMP + enterobactin + 7 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41710", "l": "1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58783", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine <=> a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47895", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211224", "l": "Association of DFF40 with DFF45 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62254", "l": "2 hydrogencarbonate(in) + Zn(2+)(in) => 2 hydrogencarbonate(out) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944266", "l": "Association of procollagen type XI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23621", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine => AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0051861", "l": "glycolipid binding", "d": ["Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53565", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928597", "l": "EPH:EFN dimers tetramerise (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52032", "l": "H2O + L-isoleucine-(+)-7-isojasmonate = (+)-7-isojasmonate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0015288", "l": "porin activity", "d": ["Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45638", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382061", "l": "Extracellular processing of novel PDGFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1878002", "l": "XYLTs transfer Xyl to core protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46827", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1236970", "l": "Proteasomal clevage of exogenous antigen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392064", "l": "G alpha (z) inhibits adenylate cyclase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.314050959231352", "identifiers": [{"i": "GO:0019199", "l": "transmembrane receptor protein kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444171", "l": "Receptor FFAR2 binds carboxylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202960", "l": "Caspase mediated cleavage of C-IAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16686", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA => a dolichyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851298", "l": "GPR143 binds L-Dopa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57387", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA <=> (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17668", "l": "L-lysyl-[protein] + octanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51776", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59401", "l": "L-2-aminohexanoate => D-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802834", "l": "RAS GTPase mutants don't hydrolyze GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48417", "l": "a ganglioside GA2 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM2 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40567", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 = A + dTDP-beta-L-evernitrose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46369", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951951", "l": "RUNX3 binds EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.2", "l": "\"adenylosuccinate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008989", "l": "rRNA (guanine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10293", "l": "acetyl-CoA + D-glucosamine 6-phosphate => CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11797", "l": "ecdysone + O2 => 3-dehydroecdysone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46412", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34880", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate => 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3076905", "l": "Extracellular BTD hydrolyses BCTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43540", "l": "ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": [], "t": []}, {"i": "EC:2.7.11.5", "l": "\"[isocitrate dehydrogenase (NADP(+))] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004797", "l": "thymidine kinase activity", "d": ["Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193650", "l": "p75NTR binds to NADE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901641", "l": "ITP binding", "d": ["Binding to ITP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55683", "l": "(2S)-2-amino-4-deoxychorismate <=> anthranilate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26320", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37869", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29044", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061761", "l": "alpha-latrotoxin receptor binding", "d": ["Binding to an alpha-latrotoxin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32979", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51889", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) => 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450387", "l": "HuR binds the CRM1 nuclear export machinery (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46100", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = cortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74075", "l": "H(+) + NADH + phylloquinone = NAD(+) + phylloquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16536", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21475", "l": "ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77340", "l": "(2S)-2-aminobutanoate + glyoxylate => 2-oxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102454", "l": "cyanidin 3-O-galactosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72715", "l": "(R)-dihydrolipoate + ATP + H(+) = diphosphate + N(6)-[(R)-dihydrolipoyl]-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60658", "l": "1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58394", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198669", "l": "p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.15", "l": "\"DNA-deoxyinosine glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814094", "l": "ARL1:GTP binds ARFIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944225", "l": "Association of procollagen type XVII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805470", "l": "AMPK phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35895", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52661", "l": "an L-alpha-amino acid + ATP + holo-[ACP] => AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35907", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34695", "l": "(2E,6E)-farnesyl diphosphate = Delta(6)-protoilludene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.135", "l": "\"Delta(6)-protoilludene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52202", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => 1-aci-nitro-2-(phenyl)ethane + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449117", "l": "TXLNA (IL14) binds syntaxin1A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66144", "l": "5-methoxytryptamine + acetyl-CoA = CoA + H(+) + melatonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77477", "l": "ammodendrine + CoA => acetyl-CoA + tetrahydroanabasine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50433", "l": "AH2 + prostaglandin G1 => A + H2O + prostaglandin H1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29045", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854408", "l": "APOBR dimer binds VLDLs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858346", "l": "AMHR2 binds AMH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.8", "l": "\"guanylate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27931", "l": "(R)-4-phosphopantoate + ATP + beta-alanine => (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27284", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+) => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473594", "l": "Collagen type II degradation by MMP15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56194", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63849", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 => 2 3',4'-dihydroxyaurone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68049", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine => [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60949", "l": "(S)-eriodictyol + S-adenosyl-L-methionine => (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30340", "l": "H(+) + L-tryptophan => CO2 + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59791", "l": "H2O + NAD(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44946", "l": "1-O-alkyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-3-acyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000243", "l": "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46173", "l": "ATP + butanoate + CoA => AMP + butanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050120", "l": "N-acetylhexosamine 1-dehydrogenase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + NAD+ = N-acetyl-D-glucosaminate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202222", "l": "Phosphorylation of PKC theta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033039", "l": "ionotropic salty taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a soluble salty compound has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201515", "l": "Active ALK recruits PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39342", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985594", "l": "MYO9B inactivates RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036106", "l": "peroxisome membrane class-2 targeting sequence binding", "d": ["Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047519", "l": "quinate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140741", "l": "WNT5A binds FZD and ROR receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39615", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA = (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33335", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046575", "l": "rhamnogalacturonan acetylesterase activity", "d": ["Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622737", "l": "FOXO3,FOXO6,(FOXO1) binds CAT gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47472", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH = (3E)-tetradecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888577", "l": "Synthesis of GABA by GAD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.3", "l": "\"aldose 1-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51391", "l": "acetyl-CoA + dopamine <=> CoA + H(+) + N-acetyl-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59136", "l": "ATP + citrate + D-ornithine = AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": [], "t": []}, {"i": "EC:6.3.2.58", "l": "\"D-ornithine--citrate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21046", "l": "(Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine => 24-methylidenelophenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29659", "l": "O-acetyl-L-serine(in) = O-acetyl-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15454", "l": "S-adenosyl-L-methionine + sarcosine => H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15543", "l": "DIMBOA beta-D-glucoside + H(+) + UDP => DIMBOA + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42570", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2,3-dihydroxy-p-cumate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198314", "l": "DAG stimulates protein kinase C-delta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709883", "l": "BIL:ALB scavenges O2.- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70350", "l": "bromide + L-tyrosine + NADP(+) <=> 3-bromo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062124", "l": "4-hydroxybutyrate receptor activity", "d": ["Combining with 4-hydroxybutyrte to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202604", "l": "Formation of a heteromeric BMP receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948569", "l": "miR-19b microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761025", "l": "ZEB2 and SP1 bind CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41276", "l": "H2O + N-eicosanoyl-sphing-4-enine => eicosanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333612", "l": "MeSebGalNac is oxidatively cleaved to MeSeO2H and 2-acetamidoglucal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847968", "l": "PTEN binds FRK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19969", "l": "hydroxylamine + O2 = H(+) + H2O + nitrite", "d": [], "t": []}, {"i": "EC:1.7.3.6", "l": "\"hydroxylamine oxidase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39358", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64885", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP => (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20152", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046702", "l": "galactoside 6-L-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938063", "l": "SERPINB13 gene expression is inhibited by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72294", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299338", "l": "Activation of TRESK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16408", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) <=> benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58622", "l": "decanamide + glyoxylate => N-decanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844438", "l": "NLRP1 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56429", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004458", "l": "D-lactate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160134", "l": "protein-RNA sequence-specific adaptor activity", "d": ["A protein adaptor activity characterized by the capacity to selectively recognize and interact with RNA molecules in a sequence-specific manner. Entities possessing this activity typically exhibit discerning binding preferences for specific nucleotide sequences within RNA molecules, enabling the identification and engagement of distinct RNA motifs or structural elements. This function is integral to various biological processes, including RNA processing, transport, and regulatory mechanisms, contributing to the specificity and precision of cellular RNA-related activities."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18935", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645598", "l": "RRAGC,D hydrolyzes GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.68", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45765", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) => 2 H(+) + L-aspartate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848713", "l": "PTK6 binds BCAR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40626", "l": "H2O + tritetradecanoylglycerol <=> 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003689", "l": "DNA clamp loader activity", "d": ["Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.8", "l": "\"ribonuclease M5\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73800", "l": "SAICAR => AICAR + Fumarate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29267", "l": "L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66083", "l": "2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10141", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.-", "l": "\"Acting on phosphates\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507871", "l": "Aquaporins passively transport glycerol out of cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48862", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => 18-HEPE + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473594", "l": "Collagen type II degradation by MMP15 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16124", "l": "5,6-dihydrouracil + H2O <=> 3-(carbamoylamino)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990699", "l": "palmitoleyl hydrolase activity", "d": ["Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24519", "l": "acetyl-CoA + gentamicin C1a <=> CoA + H(+) + N(2')-acetylgentamicin C1a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55588", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54208", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16230", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16932", "l": "2 benzoyl-CoA + L-ornithine <=> 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635102", "l": "GPR161 is internalized (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58010", "l": "(20S)-ginsenoside Rg1 + H(+) + UDP => (20S)-ginsenoside F1 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17235", "l": "L-fuculose => L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172126", "l": "DAP12 interacts with NKG2C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164834", "l": "Enzyme-bound ATP is released (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33645", "l": "(9Z)-tetradecenoyl-CoA + AMP + diphosphate => (9Z)-tetradecenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038200", "l": "ethylene receptor histidine kinase activity", "d": ["Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30922", "l": "A + rhodopin <=> (3E)-3,4-didehydrorhodopin + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41149", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60826", "l": "2 AMP + 2 H(+) => H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352994", "l": "3-phosphoglycerate <=> 2-phosphoglycerate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034575", "l": "4-isopropylaniline dehydrogenase activity", "d": ["Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39737", "l": "3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070064", "l": "proline-rich region binding", "d": ["Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731141", "l": "Syndecan-1 binds fibronectin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6790038", "l": "Expression of HSP90B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904067", "l": "ascr#2 binding", "d": ["Binding to ascr#2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54253", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0036408", "l": "histone H3K14 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850797", "l": "SPINK6 binds KLK13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20364", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48926", "l": "an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP + H(+) => a ganglioside GM4 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28965", "l": "H(+)(in) + L-proline(in) => H(+)(out) + L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73881", "l": "histamine(in) => histamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222128", "l": "NOC2L binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77633", "l": "1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75252", "l": "carminate + O2 => 3'-dehydrocarminate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61763", "l": "rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69064", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27511", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine => dehydro coenzyme F420-0 + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10390", "l": "CO2 + GDP + phosphoenolpyruvate => GTP + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690449", "l": "S1PR1 bind S1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167181", "l": "Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69528", "l": "chorismate + H2O + 2 L-glutamine = 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:2.6.1.123", "l": "\"4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64172", "l": "L-altrarate = galactarate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050088", "l": "mannose-6-phosphate 6-reductase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + 3 H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16291", "l": "(R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH => (1R,2S)-ephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018525", "l": "4-hydroxybenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50437", "l": "prostaglandin H1 => prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32265", "l": "L-alanine + succinate semialdehyde => 4-aminobutanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47103", "l": "choloyl-CoA + taurine <=> CoA + H(+) + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683925", "l": "ULK1 is dephosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26481", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) <=> a 2-demethylmenaquinol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31897", "l": "alpha-humulene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202709", "l": "JAM2 dimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214324", "l": "Collagen type VII dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607744", "l": "MALT1 binds BCL10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52659", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) <=> a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43925", "l": "NAD(+) + pregnenolone => H(+) + NADH + pregn-5-ene-3,20-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030787", "l": "inositol 4-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432148", "l": "Fgr may phosphorylate p38 MAPK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56597", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 => (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36739", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36338", "l": "D-glucuronate + H2O + NAD(+) <=> D-glucarate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32847", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36957", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40556", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652099", "l": "Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070748", "l": "interleukin-35 receptor binding", "d": ["Binding to an interleukin-35 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761474", "l": "AMOT-2 binds CDH11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75025", "l": "9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59190", "l": "D-histidine => L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17018", "l": "acetyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] => CoA + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36195", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687465", "l": "MRN complex binds RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781941", "l": "WNTs are secreted in exosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44350", "l": "ADP + dapdiamide B + H(+) + phosphate => ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22872", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": [], "t": []}, {"i": "EC:1.14.11.7", "l": "\"procollagen-proline 3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956568", "l": "RUNX1 binds the core TAL1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25658", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.143", "l": "\"(+)-menthofuran synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109858", "l": "MAP2K2 binds MAPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38966", "l": "ATP + H2O + leukotriene C4(in) <=> ADP + H(+) + leukotriene C4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-847070", "l": "Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40225", "l": "4,8-dimethylnonanoate + CoA + H(+) => 4,8-dimethylnonanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69704", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O => beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604731", "l": "Autocatalytic activation of MMP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987007", "l": "p-STAT1 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948066", "l": "K63polyUb-IRAK1 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14358", "l": "ATP + riboflavin => ADP + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.-", "l": "\"With H(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32722", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080103", "l": "4-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19036", "l": "an N-acyl-D-glucosamine <=> an N-acyl-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102850", "l": "1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity", "d": ["Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor = 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047493", "l": "ceramide cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49634", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+) => (2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40726", "l": "(9E)-octadecenoyl-CoA + H2O <=> (9E)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12699", "l": "ADP + dGDP => ATP + dGMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132759", "l": "TCN1 binds RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038102", "l": "activin receptor antagonist activity", "d": ["Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631885", "l": "PRDX1 overoxidizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202722", "l": "CD48 binds CD244 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13047", "l": "ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17913", "l": "H2O + NAD(+) + nitrite = H(+) + NADH + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0097001", "l": "ceramide binding", "d": ["Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28322", "l": "UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71604", "l": "2-oxoglutarate(out) + oxaloacetate(in) => 2-oxoglutarate(in) + oxaloacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032563", "l": "dADP binding", "d": ["Binding to dADP, deoxyadenosine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52421", "l": "O-phospho-L-serine + thiosulfate => phosphate + S-sulfo-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54943", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168641", "l": "TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047037", "l": "salutaridine reductase (NADPH) activity", "d": ["Catalysis of the reaction: (7S)-salutaridinol + NADP+ = H+ + NADPH + salutaridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75308", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) => D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70392", "l": "3-oxosphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028583", "l": "Phosphorylation of YAP by LATS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24241", "l": "A + AMP + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102371", "l": "betulin dehydrogenase activity", "d": ["Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 = betulinic aldehyde + NADP(3-) + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67758", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60208", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.67", "l": "\"[histone H3]-trimethyl-L-lysine(4) demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378975", "l": "Follitropin is a heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190245", "l": "FGFR1b binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696267", "l": "RND3 binds GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009672", "l": "auxin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022831", "l": "narrow pore, gated channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855648", "l": "SALM3 binds LAR-RPTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035380", "l": "very long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36000", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57267", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP <=> GDP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140320", "l": "PAMP receptor decoy activity", "d": ["Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31060", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) => 2 H(+) + imidazole-4-acetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74916", "l": "a (2E)-enoyl fatty acid + ATP + H(+) => a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47167", "l": "4alpha-carboxyzymosterol + NAD(+) <=> CO2 + NADH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051508", "l": "stigmasterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696670", "l": "CHD1L is recruited to GG-NER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55650", "l": "CO2 + H(+) + succinate + validoxylamine B => 2-oxoglutarate + O2 + validoxylamine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40012", "l": "(+)-copalyl diphosphate + H2O => diphosphate + manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050133", "l": "N6-hydroxylysine O-acetyltransferase activity", "d": ["Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33176", "l": "4-hydroxyphenylacetate(in) => 4-hydroxyphenylacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30385", "l": "(-)-7-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57455", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73528", "l": "TDP(out) + UTP(in) => TDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53030", "l": "H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36359", "l": "2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602454", "l": "proMMP9 binds TIMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70573", "l": "argininosuccinate <=> fumarate + arginine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016490", "l": "structural constituent of peritrophic membrane", "d": ["The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65046", "l": "4-cyanobenzaldehyde + H(+) + NADH => 4-cyanobenzyl alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680262", "l": "SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62022", "l": "D-glucose + sitosterol => H2O + sitosteryl 3-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74839", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) = UDP(out) + UDP-alpha-D-glucuronate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645428", "l": "ALPK1 binds ADP-heptose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102606", "l": "octat-9-en-7-ol 5-monooxygenase activity", "d": ["Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ = cyclooctat-9-en-5,7-diol + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004097", "l": "catechol oxidase activity", "d": ["Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018494", "l": "FOXA1 and GATA3 bind TFF genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11809", "l": "bergaptol + S-adenosyl-L-methionine => bergapten + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63114", "l": "AH2 + ascofuranone => A + ascofuranol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43750", "l": "AMP + diphosphate + hexacosanoyl-CoA => ATP + CoA + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41038", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51907", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706304", "l": "Active FLT3 binds to GRAP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66587", "l": "3-oxocholestane + A + H2O <=> 25-hydroxy 3-oxocholestane + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17535", "l": "an aromatic oxo-acid + L-glutamate => 2-oxoglutarate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432164", "l": "Ca2+ influx into the post-synaptic cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047836", "l": "D-tryptophan N-malonyltransferase activity", "d": ["Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27822", "l": "hydrogen sulfide + O-acetyl-L-homoserine = acetate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165179", "l": "Formation of TSC1:TSC2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30062", "l": "(S)-dihydroorotate + fumarate <=> orotate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16257", "l": "alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.231", "l": "\"alpha,alpha-trehalose phosphorylase (configuration-retaining)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55598", "l": "a globoside NORint + H(+) + UDP => a globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24810", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-990489", "l": "Kinesin-13 is a dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432143", "l": "PECAM-1 binds PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35988", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004156", "l": "dihydropteroate synthase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357828", "l": "RIPK1 is cleaved by CASP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-139941", "l": "Binding of IP3 to IP3 receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007646", "l": "CBX5 gene expression is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37763", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77063", "l": "1-cyclohexylethanamine + H2O + NADP(+) = 1-cyclohexylethanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956659", "l": "ABL1 phosphorylates YAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.45", "l": "\"aromatic aldoxime N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48969", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 => [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55733", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34648", "l": "S-adenosyl-L-methionine + squalene => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358790", "l": "RNF41 ubiquitinates ERBB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55847", "l": "calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77077", "l": "Capping complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52827", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247939", "l": "CysGly translocates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55120", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59342", "l": "1'-hydroxy-demethylspheroidene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53058", "l": "H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27717", "l": "GMP + H2O <=> guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729283", "l": "Nucleoprotein is methylated by PRMT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6782943", "l": "UV-DDB ubiquitinates XPC (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59150", "l": "AMP + diphosphate + marinoloyl-CoA C => ATP + CoA + marinolate C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37749", "l": "1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794346", "l": "NRXNs bind NLGNs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851436", "l": "CFHR dimers bind C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610722", "l": "CK1 phosphorylates p-GLI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043221", "l": "SMC family protein binding", "d": ["Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802943", "l": "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20765", "l": "(S)-methylmalonyl-CoA + pyruvate => oxaloacetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48187", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61670", "l": "2-hydroxybenzoyl-CoA + AMP + diphosphate => ATP + CoA + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856930", "l": "EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57602", "l": "a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52196", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933533", "l": "Dimerization of p-IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047571", "l": "3-oxosteroid 1-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052821", "l": "DNA-7-methyladenine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44701", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) => a (2E)-enoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033442", "l": "AAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33893", "l": "chanoclavine-I aldehyde + H(+) + NADH => chanoclavine-I + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15557", "l": "ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.11", "l": "\"ABC-type Ni(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874079", "l": "PTK2 binds activated MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43325", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58519", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11212", "l": "indole + O2 = 2-formamidobenzaldehyde", "d": [], "t": []}, {"i": "EC:1.13.11.17", "l": "\"indole 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15772", "l": "adenosylcob(III)inamide + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76137", "l": "a dicarboxylate(out) + urate(in) => a dicarboxylate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74919", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140761", "l": "sequestered tissue factor -> tissue factor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58454", "l": "H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0008988", "l": "rRNA (adenine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17833", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.97", "l": "\"3-hydroxyanthranilate 4-C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981539", "l": "C3b binds to cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805426", "l": "CARD8 binds CASP9(1-416) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30852", "l": "beta-D-fructose 1-phosphate => D-glyceraldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47362", "l": "an aliphatic alcohol + decanoate + H(+) => decanoate ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210881", "l": "Dimerization of Tie2/Ang1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25013", "l": "H(+) + N,N-dihydroxy-L-tryptophan = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66136", "l": "acetyl-CoA + tyramine = CoA + H(+) + N-acetyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15610", "l": "ATP + D-ribose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50757", "l": "NADP(+) + reduced [flavodoxin] => 2 H(+) + NADPH + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944263", "l": "Association of procollagen type II (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613497", "l": "Unwinding DNA for the nascent transcript (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130194", "l": "ABL phosphorylates WAVEs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64145", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine => (9Z)-octadecenoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031386", "l": "protein tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66708", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53735", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate <=> 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46381", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64204", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58817", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72115", "l": "glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77152", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 4,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917730", "l": "Cargo Recognition And Sorting (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070747", "l": "interleukin-35 receptor activity", "d": ["Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70217", "l": "20beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134962", "l": "DHX36 binds DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264834", "l": "Endocytosis and degradation of apoA-I (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14503", "l": "2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+) => H2O + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.218", "l": "\"5-methylphenazine-1-carboxylate 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047905", "l": "fructose-6-phosphate phosphoketolase activity", "d": ["Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130504", "l": "Cleavage of lip22 to lip10 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169719", "l": "Secreted CD14 binds LPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669012", "l": "EDA binds EDAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58746", "l": "diphosphate + H(+) + N(7)-methyl-GMP => H2O + N(7)-methyl-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404193", "l": "IGF1R phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27671", "l": "1D-myo-inositol 1-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187575", "l": "Ubiquitination of phospho-p27/p21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.100", "l": "\"(R)-amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77548", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426223", "l": "Cation influx mediated by TRPC3/6/7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046180", "l": "KSPG is secreted from the cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848939", "l": "PTK6 binds KHDRBS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689317", "l": "Formation of the pre-incision complex in GG-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23807", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate <=> N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24990", "l": "calcitroate + H2O + 2 oxidized [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19800", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O <=> 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10064", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": [], "t": []}, {"i": "EC:2.1.2.7", "l": "\"D-alanine 2-hydroxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45144", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + CO2 + CoA + methanethiol", "d": [], "t": []}, {"i": "EC:4.2.1.155", "l": "\"methylthioacryloyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226979", "l": "ADD1:ADD2 binds DMTN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31174", "l": "(3S)-hydroxytetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40323", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49763", "l": "EDTA + FMNH2 + O2 <=> ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54229", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19321", "l": "N,N-dimethylaniline N-oxide = formaldehyde + N-methylaniline", "d": [], "t": []}, {"i": "EC:4.1.2.24", "l": "\"dimethylaniline-N-oxide aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62746", "l": "(S)-2-methylbutanoate + compactin diol lactone + H(+) => H2O + mevastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70219", "l": "corticosterone + H(+) + NADPH = 20beta-dihydrocorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13237", "l": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.16", "l": "\"glutamine--fructose-6-phosphate transaminase (isomerizing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043719", "l": "2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990053", "l": "DNA-5-methylcytosine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186765", "l": "PLC-gamma binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54444", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199839", "l": "AKT can phosphorylate RSK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421835", "l": "trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41114", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052657", "l": "guanine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64052", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine = CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41824", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72697", "l": "Start codon recognition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34451", "l": "dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose", "d": [], "t": []}, {"i": "EC:5.1.3.25", "l": "\"dTDP-L-rhamnose 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66873", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247849", "l": "WLS dissociates from retromer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18379", "l": "ADP + H(+) + streptomycin 3''-phosphate => ATP + streptomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47134", "l": "11-cis-retinoate + 2 H(+) + NADH => 11-cis-retinal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77305", "l": "5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine => N(omega),N(omega)-dimethyl-L-arginine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45406", "l": "1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29888", "l": "ATP + H2O + L-lysine(out) => ADP + H(+) + L-lysine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41560", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.15", "l": "\"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112271", "l": "The receptor:G-protein complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76117", "l": "6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + O2 + thebaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.449651719305677", "identifiers": [{"i": "GO:0031406", "l": "carboxylic acid binding", "d": ["Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621242", "l": "CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43242", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37151", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43243", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58883", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45094", "l": "octanoate + sphing-4-enine => H2O + N-octanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14353", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5-phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.85", "l": "\"3-dehydro-L-gulonate-6-phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22573", "l": "A + H2O + N-methyl-L-glutamate => AH2 + formaldehyde + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75836", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione => (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54463", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033447", "l": "AGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19675", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) => 1,2,3-trihydroxybenzene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695964", "l": "ABHD14B hydrolyses PNPB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53284", "l": "NAD(+) + scyllo-inosose = 3-dehydro-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53877", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57892", "l": "a quinone + 5 H(+)(in) + NADPH = a quinol + 4 H(+)(out) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55003", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52386", "l": "H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate => L-glutamate + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59676", "l": "D-maltotetraose + O2 = D-maltotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62867", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine <=> 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21392", "l": "2-phenylacetaldehyde + H2O + NAD(+) = 2-phenylacetate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.39", "l": "\"phenylacetaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47969", "l": "a ganglioside GM2 + H2O => a ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014467", "l": "RHOG binds effectors at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71140", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH => 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31081", "l": "3-methyl-(2E)-butenoyl-CoA + H2O => 3-hydroxyisovaleryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450348", "l": "Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53025", "l": "a plastoquinone + H2O + L-arginine => 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416516", "l": "GRK2 sequesters activated Gq (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19101", "l": "2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.165", "l": "\"2-alkyn-1-ol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35341", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => 3-hydroxyicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140431", "l": "DNA-(abasic site) binding", "d": ["Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71534", "l": "guanine(out) <=> guanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13018", "l": "diphosphate + UMP => 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944099", "l": "Activated PPARG binds PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20472", "l": "H2O + IMP <=> D-ribose 5-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62872", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 = H2O + NADP(+) + semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73882", "l": "histamine(out) <=> histamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55220", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}, {"i": "EC:1.14.18.9", "l": "\"4alpha-methylsterol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9680443", "l": "ROCK1,2 bind ROCKi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.212", "l": "\"endo-(1->4)-fucoidanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75879", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine = methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": [], "t": []}, {"i": "EC:2.1.1.388", "l": "\"proline betaine--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62591", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) <=> 4-hydroxybenzyl alcohol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63298", "l": "H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine => an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43210", "l": "5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34763", "l": "(S,S)-tartrate(out) + succinate(in) = (S,S)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21794", "l": "acetone + H(+) + NADPH => NADP(+) + propan-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114354", "l": "SMAC binds XIAP:Caspase-7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50148", "l": "a fatty acid ethyl ester + H2O = a fatty acid + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931981", "l": "RUNX1 binds ESR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25541", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46969", "l": "A + dihydroisopentenyldehydrorhodopin => AH2 + isopentenyldehydrorhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102459", "l": "8-oxo-dADP diphosphate phosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43285", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674140", "l": "PAQR3 binds inactive RAFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72218", "l": "2 hydrogencarbonate(out) + Na(+)(out) <=> 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.79", "l": "\"arogenate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.6", "l": "\"ribonuclease IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74486", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 <=> (-)-cyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002428", "l": "Removal of fibrillar collagen N-propeptides (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44530", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24866", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 => 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22513", "l": "3 H(+) + precorrin-8X => hydrogenobyrinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695964", "l": "ABHD14B hydrolyses PNPB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19410", "l": "cholate + NAD(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682992", "l": "KDM4A,B bind H4K20Me2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247836", "l": "Retromer recycles WLS to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389862", "l": "Conversion of glyoxylate to oxalate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59760", "l": "apigenin + UDP-alpha-D-glucose = apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392513", "l": "Rap1 signal termination by Rap1GAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10573", "l": "vinylacetyl-CoA => (2E)-butenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61222", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64493", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] => dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19974", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23537", "l": "alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508451", "l": "PTK2B is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47338", "l": "16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844619", "l": "AIM2 binds dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10482", "l": "4-hydroxy-2-oxoglutarate + L-glutamate => 2-oxoglutarate + 4-hydroxy-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16789", "l": "a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043715", "l": "2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity", "d": ["Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23494", "l": "UDP-alpha-D-galactosamine => UDP-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22610", "l": "(2S,6S)-2,6-diaminoheptanedioate + succinate => H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74043", "l": "L-alanine(in) + L-methionine(out) = L-alanine(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836769", "l": "RSV dsRNA binds DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55774", "l": "a jasmonyl-L-amino acid + AMP + diphosphate + H(+) => a jasmonate + an L-alpha-amino acid + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199910", "l": "MSK1 activates ATF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48700", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47320", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate = 3-oxo-3-phenylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38663", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39346", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015086", "l": "cadmium ion transmembrane transporter activity", "d": ["Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098697", "l": "ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29881", "l": "ADP + H(+) + L-arginine(in) + phosphate => ATP + H2O + L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56007", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32036", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.140", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183072", "l": "EGFR non-clathrin mediated endocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14997", "l": "deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.46", "l": "\"deoxylimonate A-ring-lactonase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62894", "l": "6 CO2 + 7 CoA + 2 H2O + nor-toralactone => acetyl-CoA + 6 H(+) + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31283", "l": "FAD + H(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864718", "l": "TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167429", "l": "The receptor:G-protein complex  binds GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58529", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH => (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50949", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798044", "l": "BTG2 binds CCR4-NOT complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44581", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) => 2-all-trans-decaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25653", "l": "(2S)-2-amino-3-oxobutanoate + H(+) = aminoacetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73741", "l": "dopamine(out) + 2 H(+)(in) => dopamine(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928624", "l": "EPHBs bind EFNBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60375", "l": "D-fructose(out) <=> D-fructose(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445072", "l": "Interaction of PAK1 with Rac1-GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31921", "l": "3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25794", "l": "ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63812", "l": "ATP + N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46704", "l": "ATP + H(+) + salicylate = 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667037", "l": "RHPN2 binds RHOB:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647977", "l": "ICMT methylates S-Farn RAS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12219", "l": "9H-fluoren-9-ol + NAD(+) <=> 9H-fluoren-9-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75607", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163625", "l": "Glucagon binds to Glucagon receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34588", "l": "2-oxoglutarate + O2 + pentalenolactone E => CO2 + pentalenolactone F + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55109", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840488", "l": "PSAP(195-273) forms a dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50360", "l": "(R)-mandelonitrile + O2 = benzoyl cyanide + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.49", "l": "\"(R)-mandelonitrile oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676255", "l": "Formation of the MLL2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11671", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71485", "l": "L-phenylalanyl-L-methionine + L-tyrosylglycylglycine => H2O + Met-enkephalin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749253", "l": "Formation of MCM2-7 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20684", "l": "cis-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730835", "l": "Autophosphorylation of PKC-theta (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49002", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34589", "l": "CO2 + pentalenolactone F + succinate => 2-oxoglutarate + O2 + pentalenolactone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627089", "l": "CASP9 is phosphorylated at T412 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13336", "l": "beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10808", "l": "(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.23", "l": "\"(S)-2-hydroxypropylphosphonic acid epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694409", "l": "Nucleotide exchange on RAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56932", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49493", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62469", "l": "3,4-dihydroxybenzoate + ATP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047462", "l": "phenylalanine racemase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-phenylalanine + ATP + H2O = D-phenylalanine + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21974", "l": "precorrin-2 + S-adenosyl-L-homocysteine => precorrin-1 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718379", "l": "GNRHR binds chemical antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13589", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.4", "l": "\"methylcrotonoyl-CoA carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56906", "l": "AMP + an acyl-CoA + H(+) => an acyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38453", "l": "NADPH + (n+1) sulfur => hydrogen sulfide + NADP(+) + n sulfur", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45927", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39466", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59831", "l": "H2O + S-inosyl-L-homocysteine <=> inosine + L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.69", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58572", "l": "O-acetyl-15alpha-stemmadenine + O2 = H2O2 + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36852", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73333", "l": "cimicifugate E + CoA => (2R,3S)-piscidate + (E)-feruloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57599", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22653", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877485", "l": "RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68488", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) = CO2 + H2O + tridecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53731", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> N-acetyl-D-muramate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047584", "l": "4-oxalmesaconate hydratase activity", "d": ["Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167097", "l": "HIV Promoter Opening: First Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429860", "l": "DCP1-DCP2 complex decaps mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58251", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14738", "l": "CTP => 3',5'-cyclic CMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017491", "l": "RHOJ GEFs activate RHOJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203613", "l": "depalmitoylation of eNOS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844619", "l": "AIM2 binds dsDNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11020", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.127", "l": "\"inositol-trisphosphate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51283", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661425", "l": "BIL:ALB dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067659", "l": "Assembly of hexameric IL-6 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19505", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.34", "l": "\"indolylacetylinositol arabinosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21732", "l": "chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.27", "l": "\"anthranilate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39152", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627107", "l": "XIAP binds CASP7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38662", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46394", "l": "4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73790", "l": "dimethylallyl diphosphate + tardioxopiperazine A <=> diphosphate + variecolorin L", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50511", "l": "acetyl-CoA + N-terminal L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043767", "l": "pyrrolysyl-tRNA synthetase activity", "d": ["Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32388", "l": "dihydrocarveol + NAD(+) => dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14018", "l": "ATP + beta-nicotinamide D-riboside => ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848436", "l": "PTK6 phosphorylates CDKN1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26143", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50002", "l": "butan-1-ol + H2O + NAD(+) => butane + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983700", "l": "SYK binds the activated BCR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75319", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) = chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49599", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621035", "l": "EGR1 binds the TF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050659", "l": "N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "d": ["Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20783", "l": "ATP + GMP <=> ADP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003951", "l": "NAD+ kinase activity", "d": ["Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62279", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine <=> 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72965", "l": "acetoacetate(in) + 2 Na(+)(in) => acetoacetate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23338", "l": "diiodine + 2 H2O => 2 H(+) + H2O2 + 2 iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029453", "l": "Phosphorylation of VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004720", "l": "protein-lysine 6-oxidase activity", "d": ["Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36961", "l": "D-ribose + NAD(+) => D-ribono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805399", "l": "TAF1 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77226", "l": "gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cob(III)alamin + geneticin + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39456", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9005980", "l": "IL21 binds IL21R:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23268", "l": "guanidinoacetate + H2O = glycine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.2", "l": "\"guanidinoacetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38008", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66409", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O => ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46380", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54536", "l": "a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168412", "l": "MDP elicits a NOD2 response (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69590", "l": "IMP + uridine => inosine + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33481", "l": "CoA + lanosteryl ester => an acyl-CoA + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734687", "l": "ORC6 is phosphorylated on T195 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41245", "l": "N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41894", "l": "(2E)-tetradecenoyl-[ACP] + H2O => (3R)-hydroxytetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30094", "l": "a ubiquinone + D-alanine + H2O <=> a ubiquinol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654569", "l": "Activated FGFR1 binds FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418856", "l": "Activation of Rac1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37165", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64792", "l": "L-lysine + NADP(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034602", "l": "oxoglutarate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27349", "l": "arsenate + mycothiol = arseno-mycothiol + H2O", "d": [], "t": []}, {"i": "EC:2.8.4.2", "l": "\"arsenate-mycothiol transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.156", "l": "\"phloroisovalerophenone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995388", "l": "PP2A dephosphorylates BANF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014467", "l": "RHOG binds effectors at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222376", "l": "NOX2 generates superoxide from oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.124", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50974", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22905", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11080", "l": "dTMP + H2O = phosphate + thymidine", "d": [], "t": []}, {"i": "EC:3.1.3.35", "l": "\"thymidylate 5'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005168", "l": "neurotrophin TRKA receptor binding", "d": ["Binding to a neurotrophin TRKA receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63598", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0000293", "l": "ferric-chelate reductase activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe2+-siderophore + electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45731", "l": "(E)-caffeyl alcohol + NADP(+) <=> (E)-caffeyl aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005502", "l": "11-cis retinal binding", "d": ["Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047800", "l": "cysteamine dioxygenase activity", "d": ["Catalysis of the reaction: cysteamine + O2 = H+ + hypotaurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.11", "l": "\"carnosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59706", "l": "D-cellohexaonate + H(+) => D-cellohexaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340385", "l": "HAVCR2 binds LGALS9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25812", "l": "H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417842", "l": "P2Y10 receptor can bind to LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004726", "l": "non-membrane spanning protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27711", "l": "ATP + guanosine => ADP + GMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20616", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine <=> adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753634", "l": "GGT dimers hydrolyse APAP-SG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655262", "l": "Activated FGFR3 point, translocation and fusion mutants bind FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56755", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73991", "l": "geranylgeranyl diphosphate = beta-araneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40827", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69052", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 = 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.250", "l": "\"nitrosourea synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662986", "l": "MT2A binds copper (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44864", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68904", "l": "3-phenylpropanoate + ATP + H(+) + NADPH = 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66617", "l": "Mg(2+)(in) + 2 Na(+)(out) => Mg(2+)(out) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004338", "l": "glucan exo-1,3-beta-glucosidase activity", "d": ["Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638845", "l": "CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928615", "l": "EFNBs bind SFKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70027", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18661", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) = H(+) + L-ornithine + NADPH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.24", "l": "\"N(5)-(carboxyethyl)ornithine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19434", "l": "ATP + D-gluconate => 6-phospho-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15708", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA <=> 2 a ubiquinol + phenylglyoxylyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56288", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.74", "l": "\"albendazole monooxygenase (hydroxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21151", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose <=> 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76747", "l": "hexadecane + O2 + reduced [NADPH--hemoprotein reductase] = 9-hexadecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17447", "l": "2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669012", "l": "EDA binds EDAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36215", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980125", "l": "ITCH binds DTX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30319", "l": "H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632653", "l": "Hh-Npp binds BOC:PTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27574", "l": "(3R)-piperidine-3-carboxamide + H2O = (3R)-piperidine-3-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30272", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 => 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790038", "l": "Expression of HSP90B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40524", "l": "a quinone + succinate => a quinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205321", "l": "Interaction of KIT and sSCF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34447", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39594", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA <=> (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640862", "l": "Tankyrase binds AXIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53048", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008288", "l": "boss receptor activity", "d": ["Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497878", "l": "Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71575", "l": "5-phosphomethyl-dUMP in DNA + putrescine = 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59318", "l": "D-cellobiono-1,5-lactone + H2O2 => D-cellobiose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20129", "l": "AMP + H2O = adenine + D-ribose 5-phosphate", "d": [], "t": []}, {"i": "EC:3.2.2.4", "l": "\"AMP nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47959", "l": "3-maleylpyruvate + H2O <=> H(+) + maleate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52898", "l": "2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate => 2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65641", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.90", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464822", "l": "RDH12 reduces atRAL to atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164832", "l": "ATPase synthesizes ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008847", "l": "Enterobacter ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391941", "l": "BLT receptors can bind LTB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674531", "l": "AAMP binds EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59899", "l": "ATP + L-glutamate + L-propargylglycine <=> ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13471", "l": "5-methylbarbiturate + AH2 + H(+) => A + H2O + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102984", "l": "sulfoacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD = sulfonatoacetate + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41785", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) => CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.99.1", "l": "\"[Co(II) methylated amine-specific corrinoid protein] reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712086", "l": "ALK fusions phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046789", "l": "host cell surface receptor binding", "d": ["Binding to a receptor on the host cell surface."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43244", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24322", "l": "an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15536", "l": "(2R)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76118", "l": "2-oxoglutarate + O2 + thebaine <=> 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39194", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH <=> docosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75120", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) => all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47378", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004052", "l": "arachidonate 12(S)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18263", "l": "acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine => H2O + precorrin-5 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665871", "l": "ADRM1 binds 26S proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17161", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60810", "l": "CO2 + gibberellin A20 + H2O => gibberellin A19 + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51063", "l": "5alpha-androst-1-ene-3,17-dione + A <=> AH2 + androsta-1,4-diene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050329", "l": "tetrahydroxypteridine cycloisomerase activity", "d": ["Catalysis of the reaction: tetrahydroxypteridine = H+ + xanthine-8-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71260", "l": "2 Na(+)(out) + phosphate(out) => 2 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35718", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O <=> (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77707", "l": "GTP + UTP = 3',3'-cGMP-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050564", "l": "N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity", "d": ["Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981832", "l": "NMUR2 binds neuromedin-S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22677", "l": "chlorophyllide a + H(+) + NADPH + O2 => 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667619", "l": "AVPR1A,B,2 bind atosiban (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0035240", "l": "dopamine binding", "d": ["Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31861", "l": "glutinol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.159", "l": "\"inositol-1,3,4-trisphosphate 5/6-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74748", "l": "myricetin + S-adenosyl-L-methionine => 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25967", "l": "(R)-benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448958", "l": "Nuclear translocation of p38 MAPK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45532", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17308", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine <=> dimethylamine + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668558", "l": "NBEA binds PRKAR2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5631885", "l": "PRDX1 overoxidizes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13418", "l": "5,12-dihydroxanthommatin + NAD(+) => H(+) + NADH + xanthommatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36649", "l": "CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine => 2-hydroxyhexadecanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928639", "l": "p-EFNB binds GRB4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14225", "l": "6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.258", "l": "\"6-hydroxyhexanoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32078", "l": "geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52378", "l": "(+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210439", "l": "glutamate uptake by astrocytes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22489", "l": "S-(hydroxymethyl)glutathione => formaldehyde + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46763", "l": "2,4-dinitrotoluene + NADH + O2 <=> 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604308", "l": "NICD4 traffics to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56527", "l": "A + dihydro-heme d1 <=> AH2 + heme d1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10314", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => H(+) + NADH + O2 + terephthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34782", "l": "a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36726", "l": "2-phenylethylamine + A + H2O <=> 2-phenylacetaldehyde + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138459", "l": "WNT5A:FZD4 is endocytosed (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35682", "l": "dodecanoyl-CoA + H(+) + L-serine <=> 3-oxotetradecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37450", "l": "O2 + tetracenomycin F1 <=> H(+) + H2O + tetracenomycin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333051", "l": "RPA1 binds HSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74726", "l": "Dissociation of insulin from insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "56.202863439151976", "identifiers": [{"i": "GO:0016829", "l": "lyase activity", "d": ["Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451418", "l": "Pellino ubiquitinates IRAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997237", "l": "SH2B proteins bind JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902314", "l": "hydroquinone binding", "d": ["Binding to hydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47345", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170964", "l": "FRS2 binds to active TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54527", "l": "acetoacetate + H(+) + methylglyoxal <=> 3-hydroxyhexane-2,5-dione + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23018", "l": "(2R,3R)-dihydrokaempferol + H(+) + NADPH => (2R,3S,4S)-3,4-leucopelargonidin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56504", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0097643", "l": "amylin receptor activity", "d": ["Combining with amylin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61951", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004800", "l": "thyroxine 5'-deiodinase activity", "d": ["Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833671", "l": "CDH11 forms heterotypic trans dimer with CDH24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001108", "l": "bacterial-type RNA polymerase holo enzyme binding", "d": ["Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30312", "l": "7-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74995", "l": "epierythrostominol(in) = epierythrostominol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0001046", "l": "core promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52133", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O => a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57358", "l": "CO2 + H2O + hapalindole G + succinate => 2-oxoglutarate + chloride + H(+) + hapalindole U + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61918", "l": "ADP + fluconazole(out) + H(+) + phosphate => ATP + fluconazole(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47891", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73239", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether = H(+) + ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38841", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033569", "l": "lactoferrin transmembrane transporter activity", "d": ["Enables the transfer of lactoferrin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13502", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] => ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39218", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH <=> hexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68029", "l": "6,8-dihydroxypurine + H2O + O2 => H2O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264865", "l": "Caspase-mediated cleavage of Lamin A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55780", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate = all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17276", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) <=> 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43662", "l": "ADP + H(+) + methylmalonyl-CoA + phosphate => ATP + hydrogencarbonate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22642", "l": "3-oxosphinganine + H(+) + NADPH => NADP(+) + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591086", "l": "SERPINA5 binds activated protein C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183055", "l": "Binding of CBL to EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22418", "l": "catechol + CO2 => 3,4-dihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57653", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948757", "l": "AKT phosphorylates MKRN1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54847", "l": "H(+) + hexan-3-one + NADPH + O2 <=> ethyl butanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034859", "l": "benzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432164", "l": "Ca2+ influx into the post-synaptic cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392834", "l": "Activation of EPACs by cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331340", "l": "TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794444", "l": "ALB binds Cipro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56981", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] => 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53082", "l": "4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951966", "l": "EP300 acetylates RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49933", "l": "(3E,5Z)-octadienoyl-CoA => (2E,5Z)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017124", "l": "SH3 domain binding", "d": ["Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71394", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74781", "l": "3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => laricitrin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72977", "l": "2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+) => 2 ATP + 2 indole-3-pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52290", "l": "7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70895", "l": "N-terminal L-cysteinyl-[protein] + O2 = H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10826", "l": "H(+) + NADPH + oxaloacetate => (S)-malate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453183", "l": "p-Y348-SYK dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189069", "l": "sucrose + H2O => glucose + fructose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28684", "l": "L-aspartate + ubiquinone-8 => iminosuccinate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42346", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => H(+) + NADH + O2 + p-cumate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382053", "l": "Translocation of PDGF from ER to Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75019", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate = 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857686", "l": "FITM1, FITM2 bind TAGs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103020", "l": "1-deoxy-D-xylulose kinase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose + ATP = H+ + 1-deoxy-D-xylulose 5-phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36067", "l": "Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.196", "l": "\"cobalt-precorrin-6B (C(15))-methyltransferase [decarboxylating]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35495", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate = 4-aminobenzoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196857", "l": "PANK2 phosphorylates PanK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37822", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23360", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66402", "l": "ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycocholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44299", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008706", "l": "6-phospho-beta-glucosidase activity", "d": ["Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390597", "l": "Release Of ADP From Myosin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20682", "l": "cis-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33820", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate => 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033401", "l": "UUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUU codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51570", "l": "(25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2314686", "l": "ASA- acetylates PTGS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65328", "l": "A + chrodrimanin F = AH2 + chrodrimanin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19384", "l": "(S)-oxalosuccinate + H(+) <=> 2-oxoglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388811", "l": "CD28 homodimer binds B7-1 homodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41609", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose => 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74382", "l": "2 (S)-lactate(in) + prostaglandin H2(out) <=> 2 (S)-lactate(out) + prostaglandin H2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16505", "l": "chorismate = 4-hydroxybenzoate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.40", "l": "\"chorismate lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20589", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25930", "l": "3-methylquinolin-2(1H)-one + AH2 => 3-methylquinoline + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75070", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865547", "l": "RUNX1:CBFB binds FOXP3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611852", "l": "ADRB3 bind ADR,NAd (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77671", "l": "a globoside GalGb4Cer (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a globoside MSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66159", "l": "butanoyl-CoA + tyramine <=> CoA + H(+) + N-butanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73138", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54996", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19368", "l": "ATP + D-ribulose 5-phosphate <=> ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214864", "l": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44452", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613219", "l": "RRAD gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20426", "l": "2-oxoglutarate + ATP + hydrogencarbonate => (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950342", "l": "EBI3:CANX binds IL27 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981622", "l": "Myoglobin:oxygen dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429694", "l": "CERT1-2 complex dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102307", "l": "erythromycin C 3''-o-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26493", "l": "a secondary nitroalkane + H2O + O2 <=> a ketone + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23859", "l": "H(+) + Hg + NADP(+) <=> Hg(2+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52477", "l": "estrone + UDP-alpha-D-glucuronate => estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59842", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5,6,7,8-tetrahydrofolate + syringate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67927", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982807", "l": "JAK2 phosphorylation of GHR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205306", "l": "Interaction of SHP1 and KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59469", "l": "an S-substituted glutathione + H2O => an S-substituted L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71271", "l": "H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56577", "l": "a globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine => a globoside Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46443", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 <=> A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16687", "l": "a dolichyl hexadecanoate + CoA => di-trans,poly-cis-dolichol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41768", "l": "a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50010", "l": "4-hydroxy-6-methylpretetramide + H2O + NADP(+) => 6-methylpretetramide + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050682", "l": "AF-2 domain binding", "d": ["Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340124", "l": "CSN polymer binds CaPO4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67675", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12764", "l": "precorrin-3B + S-adenosyl-L-methionine <=> 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77196", "l": "(3Z)-decenoyl-CoA => (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004525", "l": "ribonuclease III activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67093", "l": "ATP + docosanoate(in) + H2O => ADP + docosanoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21790", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60394", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) => Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830371", "l": "Expression of GATA3 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54503", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> beta-geranylfarnesene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58709", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26556", "l": "angiotensin-(1-7) + L-phenylalanine => angiotensin II + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373732", "l": "Nephrin trans-homophilic interaction (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41895", "l": "(3R)-hydroxytetradecanoyl-[ACP] <=> (2E)-tetradecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11746", "l": "H(+) + phosphate + thiamine diphosphate => H2O + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687083", "l": "MYC binds MAPKAPK5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40137", "l": "(9Z)-tetradecenoate + CoA + H(+) => (9Z)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43769", "l": "an alkylamine + L-glutaminyl-[protein] => N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32742", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61397", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42947", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52254", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18934", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17366", "l": "ATP + H2O + Mn(2+)(out) => ADP + H(+) + Mn(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57164", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 = (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23559", "l": "D-alanine + L-glutamine <=> gamma-L-glutamyl-D-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66372", "l": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190245", "l": "FGFR1b binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65168", "l": "AH2 + O2 + preaustinoid A = A + H2O + preaustinoid A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16555", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => aldehydo-D-ribose 5-phosphate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450325", "l": "c-FOS activation by phospho ERK1/2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418172", "l": "F2R binds ARRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30508", "l": "2-demethylmenaquinone-8 + H(+) + NADH => 2-demethylmenaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52973", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37889", "l": "H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide => S-adenosyl-L-methionine + small RNA 3'-end nucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30295", "l": "GTP + pyruvate = GDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655252", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917696", "l": "Cargo Sequestration (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74341", "l": "O-3-methylbutanoyl-(R)-carnitine(out) => O-3-methylbutanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63902", "l": "(2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32007", "l": "9alpha-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442387", "l": "ZIP8 mediates zinc influx into cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349455", "l": "Phosphorylation of MDM4 by ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37925", "l": "(8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31488", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose => H(+) + soyasaponin III + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102291", "l": "11alpha-hydroxy-beta-amyrin dehydrogenase activity", "d": ["Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55043", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16121", "l": "5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.81", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17820", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658438", "l": "SPRED dimer binds NF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043717", "l": "2-hydroxyglutaryl-CoA dehydratase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381377", "l": "Expression of KLF5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46113", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021851", "l": "MECP2 binds CREB1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71697", "l": "2 H(+)(in) + L-alanyl-L-aspartate(in) => 2 H(+)(out) + L-alanyl-L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50867", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22716", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.25", "l": "\"cholesterol 24-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38586", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75117", "l": "all-trans-13,14-dihydroretinal + H(+) + NADH => all-trans-13,14-dihydroretinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59802", "l": "CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222237", "l": "SMYD2 methylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18798", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008734", "l": "L-aspartate oxidase activity", "d": ["Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062068", "l": "chloroplast photosystem II binding", "d": ["Binding to a chloroplast photosystem II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0019172", "l": "glyoxalase III activity", "d": ["Catalysis of the reaction: methylglyoxal + H2O = D-lactate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917841", "l": "Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30540", "l": "(R)-carnitinyl-CoA => (S)-carnitinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61215", "l": "myricetin + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47090", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140842", "l": "n fibrin monomers -> fibrin multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30619", "l": "2 A + all-trans-zeta-carotene = 2 AH2 + all-trans-lycopene", "d": [], "t": []}, {"i": "EC:1.3.99.26", "l": "\"all-trans-zeta-carotene desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29450", "l": "glycolate(in) <=> glycolate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004917", "l": "interleukin-7 receptor activity", "d": ["Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938356", "l": "RMB14 binds RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790038", "l": "Expression of HSP90B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56187", "l": "a globoside Gb4Cer + UDP-alpha-D-galactose <=> a globoside NOR1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694265", "l": "nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685838", "l": "CX3 complex binds D-loop structures (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202960", "l": "Caspase mediated cleavage of C-IAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41723", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72128", "l": "agmatine(in) + H(+)(out) => agmatine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74543", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (E,E,E)-alpha-springene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949580", "l": "F1Fo ATP synthase dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666001", "l": "Profilin:G-actin binds MKL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17087", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2 => 4-pyridoxate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60767", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone <=> cinerin II + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17861", "l": "21-hydroxyprogesterone = 20-hydroxy-3-oxopregn-4-en-21-al", "d": [], "t": []}, {"i": "EC:5.3.1.21", "l": "\"corticosteroid side-chain-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835473", "l": "Expression of GBX2 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038048", "l": "dynorphin receptor activity", "d": ["Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27864", "l": "guanosine + phosphate => 3'-GMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130619", "l": "TGN-lysosomal vesicle coat assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66455", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22034", "l": "glyoxylate + oxaloacetate => 3-oxalomalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140806", "l": "SERPINC1 binds SERPINC1 activators (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616368", "l": "MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35096", "l": "choline => acetaldehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69539", "l": "alpha-D-tagatopyranose 1-phosphate + ATP <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14831", "l": "acetate + L-cysteine => hydrogen sulfide + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844620", "l": "dsDNA:AIM2 clusters bind ASC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38450", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O <=> 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032067", "l": "NTRK2 activates RAS signaling through FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72392", "l": "2 hydrogencarbonate(out) + oxalate(in) => 2 hydrogencarbonate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48919", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23748", "l": "ATP + GTP = diphosphate + pppGp(2'-5')A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399711", "l": "Activation of Ca impermeable AMPA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69908", "l": "2 Na(+)(out) + uridine(out) => 2 Na(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54477", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210273", "l": "Interaction of DAP12 and NKp44 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39080", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) => 3-oxododecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29818", "l": "ATP + H2O + L-proline(out) <=> ADP + H(+) + L-proline(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047361", "l": "phosphomannan mannosephosphotransferase activity", "d": ["Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11492", "l": "H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.81", "l": "\"threonine-phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24638", "l": "H(+) + NADH => H2 + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42992", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.149", "l": "\"nephthenol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65958", "l": "ADP + estrone 3-sulfate(in) + H(+) + phosphate => ATP + estrone 3-sulfate(out) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604606", "l": "Unknown kinase phosphorylates NICD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20195", "l": "(R)-mevaldate + H(+) + NADPH => (R)-mevalonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.117", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70637", "l": "2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33927", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 = 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:1.14.13.163", "l": "\"6-hydroxy-3-succinoylpyridine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58149", "l": "ethyl acetate + H2O => acetate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69614", "l": "H2O + kojibiose <=> beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65975", "l": "a peptide antigen(in) + ATP + H2O <=> a peptide antigen(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70083", "l": "hydroxyclavatol = H2O + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177284", "l": "PKA phosphorylates PDE4B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033821", "l": "DNA beta-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33041", "l": "2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667965", "l": "ANKLE2 binds PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41852", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336184", "l": "GPR37L binds prosaposin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45054", "l": "CoA + O-(2E)-butenoyl-(R)-carnitine => (2E)-butenoyl-CoA + (R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005289", "l": "high-affinity L-arginine transmembrane transporter activity", "d": ["Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48380", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030598", "l": "rRNA N-glycosylase activity", "d": ["Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47057", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73090", "l": "AMP(out) + FAD(in) <=> AMP(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625841", "l": "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63045", "l": "H2O + mevastatin => H(+) + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008790", "l": "arabinose isomerase activity", "d": ["Catalysis of the reaction: D-arabinose = D-ribulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050101", "l": "mimosinase activity", "d": ["Catalysis of the reaction: L-mimosine + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45615", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12774", "l": "2-oxoglutarate + O2 + proclavaminate => CO2 + dihydroclavaminate + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015312", "l": "polyamine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0097004", "l": "adipokinetic hormone binding", "d": ["Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16301", "l": "H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928646", "l": "EPHAs bind EFNAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14688", "l": "A + a primary alcohol <=> AH2 + an aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23778", "l": "4-phospho-L-aspartate + ADP => ATP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093331", "l": "Ras:GTP binds p120-RasGAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0032052", "l": "bile acid binding", "d": ["Binding to a bile acid, a steroid carboxylic acids occurring in bile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693478", "l": "HTR1A binds HTR1A agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654422", "l": "Activated FGFR4 binds FRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804879", "l": "MDM2 ubiquitinates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69157", "l": "spermine dialdehyde => acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2272795", "l": "Interaction of DAP12 and KIR2DS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67667", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O <=> 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21561", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol => 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68403", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-gurjunene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850797", "l": "SPINK6 binds KLK13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59165", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] => AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41902", "l": "3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390835", "l": "DRD1,5 bind DA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18643", "l": "a menaquinol => a menaquinone + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60437", "l": "3-methylbutyl acetate + H2O => 3-methylbutanol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862733", "l": "CCR2, CCR3 bind CCL13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67458", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22646", "l": "6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + protopine + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862184", "l": "USP48 cleaves polyubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66065", "l": "2-oxohexanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39616", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73684", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17951", "l": "CO + H(+) + N-formylanthranilate => 3-hydroxy-1H-quinolin-4-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29985", "l": "cytidine(out) + H(+)(out) => cytidine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389354", "l": "Activation of Vav1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22931", "l": "4-acetamidobutanoyl-CoA + H2O <=> 4-aminobutanoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38962", "l": "a 2,3-saturated acyl-CoA + O2 <=> a (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76031", "l": "2 H2O2 => O2 + 2 H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163090", "l": "Elongation Of The Telomeric Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65193", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A => berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58917", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene => (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46480", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050582", "l": "xylitol oxidase activity", "d": ["Catalysis of the reaction: xylitol + O2 = xylose + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51250", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20424", "l": "alpha-maltose 6'-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59228", "l": "6-sulfo-alpha-D-quinovose = 6-sulfo-beta-D-quinovose", "d": [], "t": []}, {"i": "EC:5.1.3.43", "l": "\"sulfoquinovose mutarotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-178208", "l": "SMAD7 binds to SMURF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404144", "l": "Parenchymal atROL translocates to HSCs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12545", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine => 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797961", "l": "CHDH oxidises Cho to BETALD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426149", "l": "SREBP1A,1C,2 binds the ELOVL6 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0001846", "l": "opsonin binding", "d": ["Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004317", "l": "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218832", "l": "CDC42:GTP binds PAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76527", "l": "2'-deoxyguanosine + H(+) + H2O = 2'-deoxyxanthosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45928", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38355", "l": "(R)-3-phenyllactoyl-CoA = (E)-cinnamoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0140597", "l": "protein carrier chaperone", "d": ["Binding to and carrying a protein between two different cellular components by moving along with the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46195", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10704", "l": "ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)", "d": [], "t": []}, {"i": "EC:6.1.1.9", "l": "\"valine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717396", "l": "SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14086", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53713", "l": "2 Fe(III)-heme b => beta-hematin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626681", "l": "Recruitment of transition zone proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16565", "l": "2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.38", "l": "\"histidine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709663", "l": "SARS-CoV-2 9b binds TOMM70 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0043138", "l": "3'-5' DNA helicase activity", "d": ["Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48796", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52478", "l": "estrone 3-O-(beta-D-glucuronate) + H(+) + UDP => estrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770119", "l": "Formation of the Spliceosomal E complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737111", "l": "Protonated weak acid translocates across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69783", "l": "(2-aminophenyl)succinate + succinyl-CoA = 2-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60801", "l": "2-oxoglutarate + gibberellin A53 + O2 => CO2 + gibberellin A44 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003911", "l": "DNA ligase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29290", "l": "2 H(+)(in) + L-aspartate(in) <=> 2 H(+)(out) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.69", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68405", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) => 2-oxoheptanedioate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34093", "l": "(S)-2-amino-6-oxohexanoate + NH4(+) + phosphate => (5R)-5-phosphooxy-L-lysine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36530", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA <=> (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.50", "l": "\"bothrolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74998", "l": "epierythrostominol(in) <=> epierythrostominol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20771", "l": "3-phosphonopyruvate + H(+) <=> CO2 + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29962", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57536", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate = a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74799", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814831", "l": "TBC1D20 binds RAB1:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19983", "l": "H(+) + NADPH + S-formylglutathione => NADP(+) + S-(hydroxymethyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:0033293", "l": "monocarboxylic acid binding", "d": ["Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72529", "l": "1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59986", "l": "a carboxylate + L-glutamine => an N(2)-acyl-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61481", "l": "a sphingoid base + a very long-chain fatty acyl-CoA => an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694436", "l": "nsp15 forms a hexamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.25", "l": "\"tRNA-uridine aminocarboxypropyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65552", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004166", "l": "dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015226", "l": "carnitine transmembrane transporter activity", "d": ["Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610730", "l": "GSK3 phosphorylates p-GLI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70369", "l": "CoA + H(+) + N-octanoyl-3-oxosphinganine => 3-oxosphinganine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57271", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP <=> GMP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74854", "l": "acetaldehyde + dopamine <=> (R)-salsolinol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33366", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59823", "l": "2 ATP <=> adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592235", "l": "Expression of POLG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035956", "l": "Defective CYP17A1 does not cleave 17aHPROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18422", "l": "acetyl-CoA + chloramphenicol => chloramphenicol 3-acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69621", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381608", "l": "cAMP activates EPAC2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34418", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22273", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18231", "l": "glyoxylate + H(+) + NADH => glycolate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928615", "l": "EFNBs bind SFKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44112", "l": "hexadecanoyl-CoA + nonan-1-ol = CoA + nonyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411357", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16608", "l": "dodecanoyl-CoA + H2O + oxaloacetate <=> (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50410", "l": "2-heptyl-4(1H)-quinolone + H2O => 1-(2-aminophenyl)decane-1,3-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15083", "l": "acetyl-CoA + ADP + phosphate => acetate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20756", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate = 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.126", "l": "\"isocitrate O-dihydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62369", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) => Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14742", "l": "4-methylene-L-glutamine + H2O => 4-methylene-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73387", "l": "H(+)(in) + malonate(out) + phosphate(in) = H(+)(out) + malonate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72371", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) = dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665000", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11090", "l": "2 H(+) + triphosphate => H2O + trimetaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624976", "l": "FOXO1,FOXO3 binds CAV1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10897", "l": "2 H2O + limonin => 2 H(+) + limonoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48436", "l": "H2O + pentanoate ester = an aliphatic alcohol + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71097", "l": "2 Na(+)(in) + pregnenolone sulfate(in) => 2 Na(+)(out) + pregnenolone sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36351", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690023", "l": "NUBPL binds 4Fe-4S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14508", "l": "2 glutathione + thiosulfate <=> glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52120", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32593", "l": "(3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+) => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008716", "l": "D-alanine-D-alanine ligase activity", "d": ["Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48249", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) => CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71603", "l": "2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) + oxaloacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380586", "l": "loading of Serotonin in synaptic vesicles (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59082", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614544", "l": "Sulfite is oxidized to sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418846", "l": "Caspase cleavage of UNC5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20064", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate <=> a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45682", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247511", "l": "STAB2:ligand is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17013", "l": "H(+) + phosphoenolpyruvate = 3-phosphonopyruvate", "d": [], "t": []}, {"i": "EC:5.4.2.9", "l": "\"phosphoenolpyruvate mutase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25396", "l": "(9Z,12Z)-octadecadienoate + O2 => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71469", "l": "L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7) => H2O + substance P", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.7", "l": "\"kynurenine--oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72634", "l": "Ca(2+)(in) + 3 Li(+)(out) <=> Ca(2+)(out) + 3 Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14968", "l": "an acyl phosphate + H2O <=> a carboxylate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37556", "l": "D-kanosamine 6-phosphate + H2O => kanosamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22796", "l": "ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.102", "l": "\"hamamelose kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13952", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] <=> NADPH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662608", "l": "MT2A binds cadmium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30214", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77332", "l": "glyoxylate + L-ornithine => 5-amino-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60690", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADH => (11R)-dihydroartemisinic aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33228", "l": "(E)-4-coumarate + H(+) => 4-hydroxystyrene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33886", "l": "2-deoxy-scyllo-inosamine + NAD(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448962", "l": "Heterodimerization of E proteins with Myod (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43627", "l": "2-aminomalonate semialdehyde + H(+) <=> aminoacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19021", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.40", "l": "\"glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56649", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) => 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52982", "l": "7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66848", "l": "2 Cu(2+) + NADH = 2 Cu(+) + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34353", "l": "geranate + 2 H(+) + NADH => (2E)-geranial + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29878", "l": "H2O + sn-glycero-3-phospho-L-serine <=> H(+) + L-serine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17368", "l": "ATP + H2O + Mn(2+)(out) <=> ADP + H(+) + Mn(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164834", "l": "Enzyme-bound ATP is released (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53124", "l": "all-trans-lycopene = delta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853496", "l": "SCF:FBXL7 binds AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50163", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140761", "l": "sequestered tissue factor -> tissue factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874212", "l": "MBTPS1 (S1P) cleaves CREB3L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803063", "l": "RNASEs bind bacterial LPS, PGN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213464", "l": "RIPK1 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668904", "l": "Formation of the CTF18 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34500", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63589", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10247", "l": "4-fumarylacetoacetate + H2O <=> acetoacetate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61308", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40021", "l": "(-)-ent-copalol + diphosphate => ent-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809309", "l": "MTMR6 binds MTMR9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28834", "l": "D-gluconate(in) + H(+)(in) <=> D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38083", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848930", "l": "PTK6 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75196", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) => 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375138", "l": "CDO binds BOC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60984", "l": "16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29971", "l": "2'-deoxyinosine(in) + H(+)(in) = 2'-deoxyinosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30618", "l": "15-cis-phytoene + 2 A <=> 2 AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709831", "l": "HSP90 binds TBK1 and IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19864", "l": "a 16alpha-hydroxysteroid + NAD(+) <=> a 16-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13923", "l": "gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62448", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP = AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132096", "l": "Formation of C4b:factor B complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030749", "l": "loganate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730847", "l": "Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322431", "l": "XIAP binds TLE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18052", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine <=> L-glutamate + N-acetyl-L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14313", "l": "2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.26", "l": "\"iodophenol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690669", "l": "CD22 binds itself to form homo-oligomers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70388", "l": "3-oxosphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74711", "l": "Phosphorylation of IRS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12241", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48440", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60343", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38074", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29551", "l": "H2O + UDP-alpha-D-glucose = alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38378", "l": "bacterioruberin <=> bisanhydrobacterioruberin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451311", "l": "Activation of Ca-permeable Kainate receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987120", "l": "JAK1 binds IFNLR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50777", "l": "hexanal + NADP(+) => (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73063", "l": "H(+)(out) + Mn(2+)(in) = H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008703", "l": "5-amino-6-(5-phosphoribosylamino)uracil reductase activity", "d": ["Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010347", "l": "L-galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24622", "l": "H(+) + NADH + octanal => NAD(+) + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008190", "l": "eukaryotic initiation factor 4E binding", "d": ["Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69800", "l": "D-tryptophanyl-tRNA(Trp) + H2O => D-tryptophan + tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.222", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193653", "l": "NGF homodimer binds to p75NTR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67282", "l": "(1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45547", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.235", "l": "\"lipopolysaccharide core heptose(I) kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050228", "l": "pterin deaminase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65583", "l": "H2O + TTP <=> H(+) + phosphate + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202692", "l": "PIP3 binds to RhoA and activates it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4411373", "l": "NLK translocates to nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15846", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62772", "l": "N-acetyl-D-phenylalanine = N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63695", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate <=> a beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389348", "l": "Activation of Rac1 by pVav1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176445", "l": "SMURF2 binds SMAD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606326", "l": "HJURP:CENPA complex localizes to the centromere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39488", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46880", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296244", "l": "SUCNR1 binds SUCCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75324", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) => chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39542", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44914", "l": "(3E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016404", "l": "15-hydroxyprostaglandin dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615910", "l": "SUMOylation of PCNA with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39627", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA = (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.23", "l": "\"sugar-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54508", "l": "all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10349", "l": "5-oxo-L-proline + ATP + 2 H2O => ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44935", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592398", "l": "Activation of proMMP8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047726", "l": "iron-cytochrome-c reductase activity", "d": ["Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70573", "l": "argininosuccinate <=> fumarate + arginine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9652264", "l": "ERBB2 binds TKIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635868", "l": "ub-GLI is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45753", "l": "(3E)-decenoyl-CoA => (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38340", "l": "(20S)-ginsenoside Rb1 + H2O => (20S)-ginsenoside Rd + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46179", "l": "2-methylpropanoate + ATP + CoA <=> 2-methylpropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102870", "l": "7-hydroxyflavone-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone = 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35385", "l": "CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine => precorrin-6B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41154", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.133", "l": "\"N(alpha)-acyl-L-glutamine aminoacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70086", "l": "hydroxyclavatol <=> H2O + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672978", "l": "RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102140", "l": "heparan sulfate N-deacetylase activity", "d": ["Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42791", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47904", "l": "ATP + N-(acetyl)-sphing-4-enine = ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612534", "l": "Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67191", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23322", "l": "CoA + H(+) + N(2)-malonyl-D-tryptophan => D-tryptophan + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602353", "l": "Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23984", "l": "cholesterol + NADP(+) = 7-dehydrocholesterol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.21", "l": "\"7-dehydrocholesterol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65996", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) = methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": [], "t": []}, {"i": "EC:2.1.1.376", "l": "\"glycine betaine--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202466", "l": "Interaction of Bcl10 to CARMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12396", "l": "dTDP-D-galactose + H2O + 2 NADP(+) = dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.186", "l": "\"dTDP-galactose 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032030", "l": "myosin I light chain binding", "d": ["Binding to a light chain of a myosin I complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77525", "l": "(2S)-2-hydroxypentanenitrile => butanal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68058", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193695", "l": "IRAK interacts with TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33971", "l": "5''-phosphoribostamycin + H2O = phosphate + ribostamycin", "d": [], "t": []}, {"i": "EC:3.1.3.88", "l": "\"5''-phosphoribostamycin phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015090", "l": "low-affinity ferric iron ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27695", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate => (S)-3-methyl-2-oxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.38", "l": "\"gametolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008043", "l": "MAPK8 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67584", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482772", "l": "Release of platelet cytosolic components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031218", "l": "arabinogalactan endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32964", "l": "2-oxoglutaramate + H2O => 2-oxoglutarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17172", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473596", "l": "Collagen type I degradation by MMP15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551648", "l": "SUMOylation of TDG with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110011", "l": "Binding of Grb10 to the insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468040", "l": "Cohesin binds PDS5 and WAPAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199203", "l": "PANK1/3 phosphorylate PanK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56617", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene => 1,2,4-trichlorobenzene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11699", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27718", "l": "H2O + IMP = inosine + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.99", "l": "\"IMP-specific 5'-nucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045156", "l": "electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity", "d": ["Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73137", "l": "4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20294", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.-", "l": "\"Phosphoric monoester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12023", "l": "a monocarboxylic acid amide + H2O <=> a monocarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17972", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928597", "l": "EPH:EFN dimers tetramerise (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114256", "l": "CYCS:APAF1 binds procaspase-9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031850", "l": "delta-type opioid receptor binding", "d": ["Binding to a delta-type opioid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63671", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54287", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202966", "l": "Caspase mediated cleavage of HIP-55 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698925", "l": "Packaging of Viral Genome Into C Capsids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852337", "l": "GTSE1 binds TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817983", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853745", "l": "RET binds GFRA1,GFRA3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11350", "l": "ADP + arsenite(out) + H(+) + phosphate => arsenite(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49123", "l": "H(+) + NADPH + O2 + protoviolaceinate <=> H2O + NADP(+) + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22151", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] <=> a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.3", "l": "\"RNA ligase (ATP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15084", "l": "acetate + ATP + CoA <=> acetyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37119", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": [], "t": []}, {"i": "EC:2.3.1.231", "l": "\"tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}-methoxycarbonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626060", "l": "HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28884", "l": "H(+)(in) + L-threonine(in) => H(+)(out) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018686", "l": "6-hydroxy pseudo-oxynicotine monooxygenase activity", "d": ["Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19899", "l": "4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADPH + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0031559", "l": "oxidosqualene cyclase activity", "d": ["Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186778", "l": "SHP2 binds to the active receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32172", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31690", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.135", "l": "\"neopullulanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004044", "l": "amidophosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37441", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391211", "l": "Trace amine-associated receptors can bind trace amines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004369", "l": "glycerol-3-phosphate oxidase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682709", "l": "LGI4 binds ADAM22,23,11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034945", "l": "2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30077", "l": "cytosine + D-ribose 5-phosphate => CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4837364", "l": "Secretion of SOD3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975874", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18727", "l": "acetyl-CoA + vanillin => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180006", "l": "RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60755", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29496", "l": "(2E,6E)-farnesyl diphosphate + H2O => beta-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862084", "l": "PILRA,PILRB bind CD99 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609917", "l": "Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818937", "l": "MEN1 binds MLL1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213017", "l": "Auto-ubiquitination of TRAF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36848", "l": "FAD + L-threonyl-[protein] => AMP + FMN-L-threonyl-[protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0030247", "l": "polysaccharide binding", "d": ["Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55748", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.8.98.5", "l": "\"H2:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190141", "l": "ALAD binds to Pb2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46401", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49216", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.103", "l": "\"3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52268", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine = (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180021", "l": "snRNA 2'-O-ribose methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + snRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61451", "l": "H(+) + NADPH + O2 + tigecycline <=> 11a-hydroxytigecycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25177", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-methylbutanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29964", "l": "H(+)(in) + inosine(in) => H(+)(out) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928631", "l": "GIT1 binds bPIX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9623384", "l": "α1-agonists bind ADRA1A,B,D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062185", "l": "secalciferol 1-monooxygenase activity", "d": ["Catalysis of the reaction:2 H+ + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]."], "t": []}, {"i": "RHEA:49064", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72460", "l": "fumarate(in) + L-aspartate(out) => fumarate(out) + L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24778", "l": "C-13(2)-carboxypyropheophorbide a + methanol => H2O + pheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001632", "l": "leukotriene B4 receptor activity", "d": ["Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76416", "l": "Benzene is hydroxylated to phenol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008093", "l": "cytoskeletal anchor activity", "d": ["The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202721", "l": "JAM2 binds JAM3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391377", "l": "Luteinizing hormone receptor can bind LH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604294", "l": "Gamma-secretase cleaves NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47605", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GP1calpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16299", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29715", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 = FMN + glycolaldehyde + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36225", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71814", "l": "3,3',5-triiodo-L-thyronine(out) <=> 3,3',5-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10797", "l": "albendazole + H(+) + NADPH + O2 => albendazole S-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805943", "l": "S100A1 binds TLR4:LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28016", "l": "methyl thiocyanate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730872", "l": "Activation of Calcineurin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662613", "l": "MT3 exchanges zinc for copper (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73213", "l": "H(+)(out) + sucrose(in) => H(+)(in) + sucrose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49446", "l": "(2-aminobenzoyl)acetate + CoA + H(+) => (2-aminobenzoyl)acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033439", "l": "ACA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60981", "l": "12-hydroxydodecanoate + NAD(+) => 12-oxododecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336184", "l": "GPR37L binds prosaposin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11694", "l": "NADH + NADP(+) => NAD(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46104", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982017", "l": "Active G alpha (q) binds RGS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56318", "l": "3-acetylamino-4-hydroxybenzoate + CoA => 3-amino-4-hydroxybenzoate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17719", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17440", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate <=> (2E,4E)-2,4-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58139", "l": "acetate + ATP + H(+) <=> acetyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433410", "l": "SOCS1 as a regulator of KIT signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19906", "l": "NAD(+) + spermidine => dehydrospermidine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61712", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55022", "l": "5,6-diaminouracil + D-ribose 5-phosphate => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103101", "l": "UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate = H+ + 6-methylthiohexyldesulfoglucosinolate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858489", "l": "ppDVL binds DAAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379848", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17659", "l": "a 1-acylglycerone 3-phosphate + CoA => an acyl-CoA + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48923", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191303", "l": "FDPS dimer transfers IPPP to GPP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72934", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] <=> atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21676", "l": "2 dimethylallyl diphosphate = (R)-lavandulyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.69", "l": "\"lavandulyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863727", "l": "STON2 is neddylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19752", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63951", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate <=> phosphate + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990458", "l": "lipooligosaccharide binding", "d": ["Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624953", "l": "ARL13B binds INPP5E (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63960", "l": "abscisate(out) + ATP + H2O = abscisate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769015", "l": "NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11606", "l": "[O(7),N-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA => [N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25043", "l": "L-selenocysteinyl-tRNA(Sec) + 2 phosphate => H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59326", "l": "D-xylono-1,5-lactone + H2O2 => D-xylose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46777", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46245", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58375", "l": "(E)-oct-2-en-1-ol + NADP(+) <=> (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749647", "l": "CES2 hydrolyzes ASA- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63460", "l": "(2E,6E,10E)-geranylgeraniol + GTP = (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53489", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001222", "l": "transcription corepressor binding", "d": ["Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22146", "l": "D-threo-isocitrate => cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52261", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c => a bacteriochlorophyllide e + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14167", "l": "CoA + H(+) + N-acetyl-L-aspartate => acetyl-CoA + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59561", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone => H(+) + N,N',N''-triacetylchitotrionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954117", "l": "E2F6:TFDP1 binds EPC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849094", "l": "ARHGAP35 binds RASA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004615", "l": "phosphomannomutase activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.179", "l": "\"brassinosteroid 6-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507868", "l": "Aquaporins passively transport water into cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48189", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421472", "l": "2 delta-aminolevulinate => porphobilinogen + 2 H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047300", "l": "pyridoxamine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11195", "l": "an (S)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75909", "l": "ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein] => ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76299", "l": "L-aspartate(in) + L-cystine(out) = L-aspartate(out) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53836", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68542", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60019", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70684", "l": "(R)-normetanephrine + S-adenosyl-L-methionine => (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35433", "l": "cyanidin 3,7-di-O-beta-D-glucoside + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37344", "l": "adenosine 2'-phosphate + H2O => adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61404", "l": "ATP + N-(D-ribulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75282", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28109", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-D-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18074", "l": "(S)-dihydroorotate + A => AH2 + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36393", "l": "desmosterol + H(+) + NADPH => cholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34157", "l": "CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451418", "l": "Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23703", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O <=> (6R)-10-formyltetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198314", "l": "DAG stimulates protein kinase C-delta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65836", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64824", "l": "1-naphthaleneacetamide + H2O = 1-naphthaleneacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28520", "l": "D-glycero-beta-D-manno-heptose 1-phosphate + phosphate => D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031459", "l": "ABC-type glycine betaine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)."], "t": []}, {"i": "RHEA:32783", "l": "ATP + glycine betaine(out) + H2O = ADP + glycine betaine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71508", "l": "(+)-alpha-tocopherol(out) => (+)-alpha-tocopherol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392513", "l": "Rap1 signal termination by Rap1GAPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008010", "l": "structural constituent of chitin-based larval cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218806", "l": "FYN autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112429", "l": "Formation of FACT complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51370", "l": "CoA + H(+) + N-octadecanoylglycine => glycine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14341", "l": "2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO2", "d": [], "t": []}, {"i": "EC:2.2.1.5", "l": "\"2-hydroxy-3-oxoadipate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004979", "l": "beta-endorphin receptor activity", "d": ["Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75862", "l": "Fall Back to Closed Pre-initiation Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173705", "l": "C5b binds C6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392748", "l": "L1 binds to AP-2 Clathrin complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.2.-", "l": "\"Hydron translocation linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43338", "l": "CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out) => H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32102", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside <=> DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57703", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13673", "l": "[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.59", "l": "\"[protein-PII] uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67744", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O = 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37530", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25554", "l": "diphosphate + stemar-13-ene => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37656", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015220", "l": "choline transmembrane transporter activity", "d": ["Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17886", "l": "acetaldehyde => acetylene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74446", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654511", "l": "FGFRL1 dimer binds FGFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391935", "l": "DP1 receptor can bind PGD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0036313", "l": "phosphatidylinositol 3-kinase catalytic subunit binding", "d": ["Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029473", "l": "Branching and elongation of mother and daughter filaments (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856945", "l": "PP2A methylation by LCMT1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043755", "l": "alpha-ribazole phosphatase activity", "d": ["Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322429", "l": "XIAP monoubiquinates TLE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665989", "l": "DIAPH1 binds RHOA:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19264", "l": "ATP + H2O + heme b(in) <=> ADP + H(+) + heme b(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67969", "l": "H2O + presqualene diphosphate => H(+) + phosphate + presqualene monophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650473", "l": "SERPING1 is secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827882", "l": "SOX17 and TFAP2C bind the PRDM1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68464", "l": "2-butyloctyl sulfate + H2O = 2-butyloctan-1-ol + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.22", "l": "\"branched primary-alkylsulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28953", "l": "H(+)(out) + L-arabinose(out) => H(+)(in) + L-arabinose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865774", "l": "TTLLs polyglutamylate tubulin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68299", "l": "dodecanoyl-CoA + L-seryl-[protein] <=> CoA + O-dodecanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879930", "l": "STAT5 is recruited by JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24209", "l": "1,5-anhydro-D-mannitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14756", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050416", "l": "formimidoylglutamate deiminase activity", "d": ["Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.-", "l": "\"Aldehyde-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54838", "l": "H2O + NADP(+) + pentyl acetate => H(+) + heptan-2-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169895", "l": "Crk's SH3 domain engages C3G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75440", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12260", "l": "ATP + NADH = ADP + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:2.7.1.86", "l": "\"NADH kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33170", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72682", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> AMP + diphosphate + H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428511", "l": "NCK binds ROBO1:SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44629", "l": "L-dihydroanticapsin + NAD(+) => H(+) + L-anticapsin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102976", "l": "versiconal reductase activity", "d": ["Catalysis of the reaction: versiconol + NADP = versiconal hemiacetal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66568", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = preluffariellolide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11915", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0050220", "l": "prostaglandin-E synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994148", "l": "LRRC16A binds F-actin capping protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781922", "l": "USP13 binds UFD1L:SKP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112429", "l": "Formation of FACT complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37585", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => D-lysine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299297", "l": "Activation of THIK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57674", "l": "2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21884", "l": "H2O + trithionate = H(+) + sulfate + thiosulfate", "d": [], "t": []}, {"i": "EC:3.12.1.1", "l": "\"trithionate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56206", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57157", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30026", "l": "L-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28714", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) <=> H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043833", "l": "[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity", "d": ["Catalysis of the reaction: [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H+ + methyl-coenzyme M. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014454", "l": "RHOG translocates to the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56443", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76461", "l": "(E)-sinapaldehyde + AH2 => (E)-sinapyl alcohol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15091", "l": "AH2 + pyruvate => (R)-lactate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802927", "l": "BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685604", "l": "SLAMF6 binds SLAMF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14102", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 => [eIF5A protein]-hypusine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53345", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) => H(+) + NADPH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626220", "l": "C2CD3 binds the mother centriole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63500", "l": "H(+) + NADPH + S-nitrosoglutathione = NADP(+) + sulfinamide glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28489", "l": "Fe(2+)(in) <=> Fe(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654404", "l": "Activated FGFR2 binds SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031840", "l": "type 2 neuromedin U receptor binding", "d": ["Binding to a type 2 neuromedin U receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28330", "l": "H2O + ITP = H(+) + IDP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66902", "l": "CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O => acetyl-CoA + L-tryptophan + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615536", "l": "MECP2 and SOX2 bind MIR137 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871266", "l": "YAP1 binds TEAD3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27276", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23803", "l": "H2O + L-methionine <=> 2-oxobutanoate + methanethiol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12490", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34717", "l": "15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+) => 15-methylhexadecasphing-4-enine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004092", "l": "carnitine O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018778", "l": "DL-2 haloacid dehalogenase activity", "d": ["Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10344", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.25", "l": "\"plasmalogen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48125", "l": "a ganglioside GD3 (d18:1(4E)) + H2O => a ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848124", "l": "PTK6 phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13343", "l": "5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964252", "l": "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16947", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18666", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) => (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64552", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] = 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33568", "l": "A + ethanol => acetaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71819", "l": "L-thyroxine(out) = L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167427", "l": "Opioid dissociates from MOR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28029", "l": "[thioredoxin]-disulfide + dUDP + H2O <=> [thioredoxin]-dithiol + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807565", "l": "GNLY is transferred to the phagosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004115", "l": "3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70888", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) => L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37106", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167147", "l": "Separation of abortive HIV-1 transcript from template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340226", "l": "CYGB dioxygenates NO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001621", "l": "G protein-coupled ADP receptor activity", "d": ["Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654167", "l": "Activated FGFR1 binds PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30648", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) => CDP-1L-myo-inositol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52680", "l": "acetyl-CoA + L-alpha-phenylglycine = CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669868", "l": "Nilotinib-resistant KIT mutants do not bind nilotinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448591", "l": "Interleukin-32 binds proteinase-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16635", "l": "guanine + queuosine(34) in tRNA => guanosine(34) in tRNA + queuine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.10357213107482", "identifiers": [{"i": "GO:0008168", "l": "methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430135", "l": "p-SLP-76 binds ADAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023030", "l": "MHC class Ib protein binding, via antigen binding groove", "d": ["Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047714", "l": "galactolipase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:1990470", "l": "piRNA cluster binding", "d": ["Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350598", "l": "Arginine<=>Agmatine+CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23863", "l": "acetyl-CoA + deacetylcephalosporin C <=> cephalosporin C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75891", "l": "Abortive Initiation After Second Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32196", "l": "abieta-7,13-dien-18,18-diol => abieta-7,13-dien-18-al + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77615", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13289", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.15", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72966", "l": "acetoacetate(out) + 2 Na(+)(out) <=> acetoacetate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019139", "l": "cytokinin dehydrogenase activity", "d": ["Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43012", "l": "L-homocysteine = 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39052", "l": "ATP + cholesterol(in) + H2O => ADP + cholesterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626681", "l": "Recruitment of transition zone proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090586", "l": "protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380782", "l": "STAT binds to the active receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003920", "l": "GMP reductase activity", "d": ["Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59487", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O <=> arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46403", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14244", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628899", "l": "TP53 binds the TIGAR gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67186", "l": "(glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60893", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O => a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22451", "l": "ATP + pseudouridine <=> ADP + H(+) + psi-UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74383", "l": "2 (S)-lactate(in) + prostaglandin E2(out) = 2 (S)-lactate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69060", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62164", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O = D-glucosamine + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17156", "l": "CDP-D-glucose <=> CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909729", "l": "Activation of JAK kinases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76534", "l": "H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2 <=> H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68220", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol = (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47635", "l": "H2O + L-arginine + NAD(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46536", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19894", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545203", "l": "Deacetylation of cleaved cohesin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60326", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112434", "l": "Formation of DSIF complex  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984689", "l": "Kinesin-7 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70188", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose => cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050397", "l": "Watasenia-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47989", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666008", "l": "SCAI binds SRF:MKL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690494", "l": "RHOB translocates to the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11004", "l": "2 H(+) + NADH + O2 + salicylate = catechol + CO2 + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.1", "l": "\"salicylate 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72722", "l": "eIF2 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74948", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 => (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12912", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate <=> 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466861", "l": "Defective RDH12 does not reduce atRAL to atROL and causes LCA13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794475", "l": "Cipro:ALB dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2219524", "l": "PDPK1 binds PIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390649", "l": "CHRM1,3,5 bind acetylcholine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433456", "l": "Recruitment of STATs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33859", "l": "(2S-3S)-versiconal hemiacetal = H2O + versicolorin B", "d": [], "t": []}, {"i": "EC:4.2.1.143", "l": "\"versicolorin B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34731", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018542", "l": "2,3-dihydroxy DDT 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106425", "l": "3,4-dihydroxyphenylacetaldehyde synthase activity", "d": ["Catalysis of the reaction: L-dopa + O2 + H2O + H+ = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH(4)+ + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047070", "l": "3-carboxyethylcatechol 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37819", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295599", "l": "SPRY2 translocates to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34212", "l": "ecgonine methyl ester + NADP(+) => ecgonone methyl ester + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071795", "l": "K11-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693540", "l": "MRN activates ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0019786", "l": "protein-phosphatidylethanolamide deconjugating activity", "d": ["Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917693", "l": "ESCRT Disassembly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73370", "l": "D-xylose(out) + 2 Na(+)(out) <=> D-xylose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64265", "l": "atrochrysone carboxylate + H(+) => atrochrysone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21975", "l": "precorrin-1 + S-adenosyl-L-methionine <=> precorrin-2 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902516", "l": "sn-glycerol 3-phosphate binding", "d": ["Binding to sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77399", "l": "hydrogen cyanide + pentanal = (2S)-2-hydroxyhexanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140586", "l": "promoter-terminator loop anchoring activity", "d": ["Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32385", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH => (1S,2S,4R)-limonene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73879", "l": "histamine(out) = histamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23409", "l": "NADP(+) + precorrin-6B => 2 H(+) + NADPH + precorrin-6A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70488", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10111", "l": "(7S)-salutaridinol + NADP(+) <=> H(+) + NADPH + salutaridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56808", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] = adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68473", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36650", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50265", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72670", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45128", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13045", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31206", "l": "acetyl-CoA + hexanoyl-CoA <=> 3-oxooctanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043839", "l": "lipid A phosphate methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61318", "l": "germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11341", "l": "5-guanidino-2-oxopentanoate + H(+) => 4-guanidinobutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14799", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+) => 2-dehydro-3-deoxy-D-gluconate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052754", "l": "GTP:coenzyme F420 guanyltransferase activity", "d": ["Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70836", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) => L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23700", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.4.9", "l": "\"methenyltetrahydrofolate cyclohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482772", "l": "Release of platelet cytosolic components (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247960", "l": "Activation of p38 MAPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54914", "l": "11-cis-retinal + H(+) + NADPH => 11-cis-retinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46765", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618750", "l": "CaMKII phosphorylates AMPA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63891", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.014330232248525", "identifiers": [{"i": "GO:0008092", "l": "cytoskeletal protein binding", "d": ["Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672302", "l": "Phosphorylated LEPR Binds SOCS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29179", "l": "a menaquinol + 2 O2 = a menaquinone + 2 H(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1902121", "l": "lithocholic acid binding", "d": ["Binding to lithocholic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39468", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603554", "l": "NTRK3(496-641):NELFB translocates to mitochondrion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035538", "l": "carbohydrate response element binding", "d": ["Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36769", "l": "CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine => 2-hydroxytetracosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27780", "l": "2-all-trans-octaprenylphenol + CO2 => 4-hydroxy-3-all-trans-octaprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213017", "l": "Auto-ubiquitination of TRAF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483218", "l": "PG transports from the ER membrane to the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16847", "l": "citrate + CoA + H(+) => acetyl-CoA + H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50264", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623192", "l": "G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729870", "l": "KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45227", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA <=> (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033832", "l": "alpha,alpha-trehalose phosphorylase (configuration-retaining) activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26036", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16821", "l": "6-phospho-D-gluconate + NAD(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41730", "l": "18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39541", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12976", "l": "AMP + ATP <=> 2 ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873917", "l": "Translocation of STAT1 dimer to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67655", "l": "dADP + H2O <=> 2'-deoxyadenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54359", "l": "3-methyl-2-oxobutanoate + H(+) <=> 2-methylpropanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70075", "l": "acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58194", "l": "dihydrobisanhydrobacterioruberin + diphosphate => dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51725", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190265", "l": "FGFR4 binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52029", "l": "a jasmonyl-L-amino acid + H2O => a jasmonate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37203", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72693", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) => 17beta-estradiol 17-O-(beta-D-glucuronate)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67800", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047950", "l": "glutathione oxidase activity", "d": ["Catalysis of the reaction: 2 glutathione + O2 = glutathione disulfide + H2O2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58037", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => 8-epi-inunolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451481", "l": "TLR7 binds to recognized ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28629", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone => O2 + reduced [NADPH--hemoprotein reductase] + solavetivol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674018", "l": "BRAP binds RAS:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24390", "l": "alpha-D-ribose 1-phosphate + uracil => phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373705", "l": "Caspase cleavage of DCC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67975", "l": "ATP + ecdysone <=> ADP + ecdysone 22-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69303", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203977", "l": "SAR1 Activation And Membrane Binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904492", "l": "Ac-Asp-Glu binding", "d": ["Binding to Ac-Asp-Glu."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28865", "l": "H(+)(in) + lactose(out) => H(+)(out) + lactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75850", "l": "Addition of the third nucleotide on the nascent transcript (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77048", "l": "4-phenylbutan-2-amine + H2O + NAD(+) => 4-phenylbutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43693", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190141", "l": "ALAD binds to Pb2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627104", "l": "XIAP binds CASP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64121", "l": "an N-(fatty acyl)-L-serine + H2O => a fatty acid + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67472", "l": "H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465940", "l": "atRAL is reduced to atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25155", "l": "2-oxoglutarate + L-phenylalanine <=> 3-phenylpyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23163", "l": "L-rhamnopyranose <=> L-rhamnulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317332", "l": "PIP3 recruits AKT to the membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64863", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine <=> (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708457", "l": "HM13 cleaves HMOX1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62977", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O => (9Z,12Z,15Z)-octadecatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67858", "l": "3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848829", "l": "CBL autoubiquitinates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24167", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025998", "l": "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694428", "l": "LMAN family proteins bind glycosylated cargo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015055", "l": "secretin receptor activity", "d": ["Combining with secretin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74373", "l": "a carboxylate(in) + nicotinate(out) => a carboxylate(out) + nicotinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34567", "l": "CDP-alpha-D-paratose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.342", "l": "\"CDP-paratose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69377", "l": "2-hydroxydodecanoate + O2 => 2-oxododecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047292", "l": "trihydroxypterocarpan dimethylallyltransferase activity", "d": ["Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11292", "l": "2 H(+) + O2 + rifamycin B = H2O2 + rifamycin O", "d": [], "t": []}, {"i": "EC:1.10.3.6", "l": "\"rifamycin-B oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450488", "l": "BRF1 Complex recruits RNA degradation activities (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57065", "l": "D-apionolactone + H2O => D-apionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18579", "l": "3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16415", "l": "L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850777", "l": "SPINK6 binds KLK14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36995", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42825", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 => H2O + 2 NAD(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60958", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP => 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14006", "l": "H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047610", "l": "acetylsalicylate deacetylase activity", "d": ["Catalysis of the reaction: acetylsalicylate + H2O = acetate + H+ + salicylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35441", "l": "archaetidylserine + CMP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15744", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) <=> 2,5-dichlorohydroquinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42776", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.180", "l": "\"16S rRNA (adenine(1408)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.938801239267953", "identifiers": [{"i": "GO:0008194", "l": "UDP-glycosyltransferase activity", "d": ["Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule."], "t": []}, {"i": "REACT:R-HSA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033760", "l": "2'-deoxymugineic-acid 2'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + H+ + mugineate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800052", "l": "SREBP1A,1C binds the SCD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050338", "l": "thiosulfate dehydrogenase activity", "d": ["Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047054", "l": "berbamunine synthase activity", "d": ["Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61737", "l": "steviolmonoside + UDP-alpha-D-glucose => rubusoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0070704", "l": "sterol desaturase activity", "d": ["Catalysis of the introduction of a double bond into a sterol molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21326", "l": "H2O2 + oxidized [rubredoxin] => 2 H(+) + reduced [rubredoxin] + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34121", "l": "3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809944", "l": "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0022858", "l": "alanine transmembrane transporter activity", "d": ["Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75651", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate = 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048307", "l": "ferredoxin-nitrite reductase activity", "d": ["Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21364", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate = 2 6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26164", "l": "AH2 + echinenone + O2 = 4'-hydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61418", "l": "cis-trans-nepetalactol => (S)-8-oxocitronellyl enol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635102", "l": "GPR161 is internalized (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17302", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65080", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47546", "l": "cis-4-hydroxy-D-proline betaine => trans-4-hydroxy-L-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013024", "l": "RHOB binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51494", "l": "all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482772", "l": "Release of platelet cytosolic components (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061896", "l": "all-trans retinol 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinol + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]."], "t": []}, {"i": "RHEA:50292", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.53", "l": "\"all-trans-retinol 3,4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23371", "l": "H(+) + phenylglyoxylate <=> benzaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696564", "l": "USP25 deubiquitinates DDX58 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033915", "l": "mannan 1,2-(1,3)-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22035", "l": "3-oxalomalate <=> glyoxylate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507869", "l": "Aquaporins passively transport glycerol into cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45381", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48887", "l": "NADP(+) + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33245", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562541", "l": "TLR4-induced ripoptosome assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030785", "l": "[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39884", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61886", "l": "1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0071949", "l": "FAD binding", "d": ["Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2250301", "l": "Formation of lysyl-pyrrole cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46796", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659380", "l": "Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682769", "l": "LGI2 binds ADAM22,23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45883", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21391", "l": "H2O + L-2-aminohexano-6-lactam <=> L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33457", "l": "CO2 + NADPH + zymosterone => 4alpha-carboxyzymosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42777", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43836", "l": "cholesterol + H(+) + NADPH + O2 = 26-hydroxycholesterol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60918", "l": "an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65624", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035614", "l": "snRNA stem-loop binding", "d": ["Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40350", "l": "3-oxotetradecanedioyl-CoA + CoA <=> acetyl-CoA + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388503", "l": "Oxytocin receptor bind oxytocin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61779", "l": "rebaudioside D + UDP-alpha-D-glucose <=> H(+) + rebaudioside M + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49882", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015548", "l": "organomercurial transmembrane transporter activity", "d": ["Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14284", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75601", "l": "ectocarpin A + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60115", "l": "(R)-3-(indol-3-yl)lactoyl-CoA <=> (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49654", "l": "H2O + NAD(+) + violaceinate => H(+) + NADH + O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5604929", "l": "Activated protein C binds Protein S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67454", "l": "4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+) => a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199839", "l": "AKT can phosphorylate RSK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668253", "l": "Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198599", "l": "AKT phosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734475", "l": "PPARA binds fibrates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66710", "l": "2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65604", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA = CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.104", "l": "\"mannan-binding lectin-associated serine protease-2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68974", "l": "AH2 + dihydroxyacetone phosphate => A + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65484", "l": "hexan-1-ol + hexanoyl-CoA = CoA + hexyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417842", "l": "P2Y10 receptor can bind to LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23423", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> alpha,alpha-trehalose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17040", "l": "indole-3-ethanol + NADP(+) <=> H(+) + indole-3-acetaldehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11890", "l": "a carboxylate + 2 H(+) + NADPH => an aldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45468", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70162", "l": "folate(in) + H(+)(in) <=> folate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19954", "l": "a 2-oxocarboxylate + L-alanine => an L-alpha-amino acid + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15358", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose => demethyllactenocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45718", "l": "CoA + glycine betaine + H(+) => H2O + N,N,N-trimethylglycyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37401", "l": "1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68158", "l": "diphosphate + N-geranyl-L-glutamate => (2E)-geranyl diphosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030604", "l": "1-deoxy-D-xylulose-5-phosphate reductoisomerase activity", "d": ["Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30027", "l": "D-glyceraldehyde + H(+) + NADH = glycerol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685296", "l": "GATA6 binds SFTPA genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31641", "l": "H(+) + mycinamicin IV + S-adenosyl-L-homocysteine => mycinamicin III + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71367", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050235", "l": "pyridoxal 4-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + pyridoxal = 4-pyridoxolactone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52249", "l": "6 H2O + 4 Mn(3+) + O2 => 12 H(+) + 4 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169919", "l": "Glycosylation of NA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429732", "l": "Multiphospho-CERT1-2 binds PPM1L, VAPA/B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64189", "l": "an N-(fatty acyl)-L-tyrosine + H2O => a fatty acid + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62569", "l": "H2O + S-benzyl-L-cysteinylglycine => glycine + S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15033", "l": "O2 + pyridoxine = H2O2 + pyridoxal", "d": [], "t": []}, {"i": "EC:1.1.3.12", "l": "\"pyridoxine 4-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39008", "l": "a cholesterol ester(in) => a cholesterol ester(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102730", "l": "cathasterone hydroxylase activity", "d": ["Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor = teasterone + H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45063", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine <=> (9Z)-octadecenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676133", "l": "CD74 binds MIF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140849", "l": "ATP-dependent H2AZ histone chaperone activity", "d": ["A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24930", "l": "H2O + L-cystine <=> NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176298", "l": "Activation of claspin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49740", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18196", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951727", "l": "cAMP binds PKA tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13726", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794338", "l": "GKAPs bind PSD-95 members (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193684", "l": "p62 recruits an atypical PKC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33928", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 => 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433506", "l": "Phosphorylation of APS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29470", "l": "H(+)(out) + K(+)(in) <=> H(+)(in) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57048", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55711", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) <=> [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12215", "l": "9H-fluoren-9-ol + NADP(+) <=> 9H-fluoren-9-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55290", "l": "CoA + tetradecanyl tetradecanoate => tetradecan-1-ol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853429", "l": "PHLDA1 binds AURKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37651", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34825", "l": "CO2 + 2 CoA + curcumin => (E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016453", "l": "C-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350769", "l": "trans-Golgi Network Coat Activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9675026", "l": "Formation of the MLL1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71181", "l": "L-histidine(in) + L-tryptophan(out) => L-histidine(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13445", "l": "(R)-pantetheine + H2O = (R)-pantothenate + cysteamine", "d": [], "t": []}, {"i": "EC:3.5.1.92", "l": "\"pantetheine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33929", "l": "2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde => 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421831", "l": "trans-Golgi Network Coat Assembly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12716", "l": "a nucleoside 5'-phosphate + ATP <=> a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56826", "l": "A + cyclooctatin + H2O => AH2 + cyclooctat-9-ene-5,7-diol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799350", "l": "Exocytosis of specific granule membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11084", "l": "3-dehydro-L-gulonate + H(+) = CO2 + L-xylulose", "d": [], "t": []}, {"i": "EC:4.1.1.34", "l": "\"dehydro-L-gulonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28715", "l": "(R)-malate(in) + 2 H(+)(in) = (R)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65867", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O <=> 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67946", "l": "2-oxohexadecanoate + H2O2 => 2-hydroxyhexadecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679266", "l": "Beclin-1 complex translocates to the ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30640", "l": "(R)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008310", "l": "single-stranded DNA 3'-5' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28352", "l": "UDP-beta-L-arabinopyranose => UDP-beta-L-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20623", "l": "ADP + H(+) + phosphate + Zn(2+)(out) => ATP + H2O + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036456", "l": "L-methionine-(S)-S-oxide reductase activity", "d": ["Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O."], "t": []}, {"i": "RHEA:19995", "l": "[thioredoxin]-dithiol + L-methionine (S)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158399", "l": "kallikrein binds SERPING1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052862", "l": "glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group", "d": ["Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72847", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36258", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22917", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 => 4-acetoxyphenol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709317", "l": "CO binds to free ferrohemoglobin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0061783", "l": "peptidoglycan muralytic activity", "d": ["A catalytic activity that contributes to the degradation of peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8980691", "l": "RHOA GEFs activate RHOA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.1", "l": "\"pyruvate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030297", "l": "transmembrane receptor protein tyrosine kinase activator activity", "d": ["Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19644", "l": "(E)-4-coumarate + ATP + CoA <=> (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0000213", "l": "tRNA-intron endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61150", "l": "H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP => myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67710", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191784", "l": "snRNA Cap hypermethylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013145", "l": "RAC1 binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56648", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19204", "l": "2'-deoxyguanosine + ATP <=> ADP + dGMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11262", "l": "H2O2 + NADP(+) => H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003834", "l": "beta-carotene 15,15'-dioxygenase activity", "d": ["Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626228", "l": "The distal appendage proteins recruit TTBK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10904", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": [], "t": []}, {"i": "EC:1.3.99.36", "l": "\"cypemycin cysteine dehydrogenase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987214", "l": "p-STAT3 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33015", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.160", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55640", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034041", "l": "ABC-type sterol transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.755473255981116", "identifiers": [{"i": "GO:0090482", "l": "vitamin transmembrane transporter activity", "d": ["Enables the transfer of a vitamin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0019136", "l": "deoxynucleoside kinase activity", "d": ["Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209815", "l": "Tyrosine is monoiodinated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14787", "l": "diphosphate + RNA(n)-3'-uridine ribonucleotide => RNA(n) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10079", "l": "H2O + lactose <=> beta-D-galactose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14544", "l": "choloyl-CoA + H2O <=> cholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64390", "l": "4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 4 A + sn-3-O-phytanylglycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805507", "l": "APAF1 binds AVEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66882", "l": "10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66998", "l": "2-methylpentanoyl-CoA + AMP + diphosphate => 2-methylpentanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963864", "l": "CUBN dissociates from 25(OH)D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603784", "l": "PEX19:class I PMP binds PEX3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851122", "l": "p-Y705,S727 STAT3 dimer binds NOTCH gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63892", "l": "ATP + H2O + L-tryptophan = AMP + D-tryptophan + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030945", "l": "protein tyrosine phosphatase activity, via thiol-phosphate intermediate", "d": ["The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46735", "l": "(2R,6)-dimethylheptanoyl-CoA <=> (2S,6)-dimethylheptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000310", "l": "AURKA phosphorylates PLK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060308", "l": "GTP cyclohydrolase I regulator activity", "d": ["Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481044", "l": "Surface deployment of platelet alpha granule membrane components (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64249", "l": "decanoyl-CoA + glycine => CoA + H(+) + N-decanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201639", "l": "Caspase-mediated cleavage of GAS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63041", "l": "H2O + lovastatin => H(+) + lovastatin carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264622", "l": "Cho is acetylated to AcCho by CHAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56954", "l": "CDP + H(+) + phosphoenolpyruvate => CTP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636439", "l": "PtpA:Ub dephosphorylates p-Y133-VPS33B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109862", "l": "MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24121", "l": "H(+) + leukotriene E4 + NADPH + O2 => 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617457", "l": "HOXB1 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.282", "l": "\"quinate/shikimate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49015", "l": "aurachin C + H(+) + NADH + O2 <=> aurachin C epoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68654", "l": "H(+) + hydrogen sulfide + L-homolanthionine => 2 L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30470", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73941", "l": "dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine => desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15894", "l": "Co-sirohydrochlorin + 2 H(+) => Co(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73367", "l": "D-xylose(out) + 2 Na(+)(out) = D-xylose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68960", "l": "DNA polymerase epsilon binds at the origin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050636", "l": "vinorine synthase activity", "d": ["Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63520", "l": "2-isopropylphenol + H(+) + NADH + O2 = 3-isopropylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58096", "l": "1-tetracosanoylglycerol + H2O = glycerol + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75638", "l": "(9Z)-octadecenoate + O2 <=> 10-hydroperoxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350901", "l": "Iodide is organified (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73175", "l": "ADP(in) + FMN(out) = ADP(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27885", "l": "2',3'-cyclophospho-CMP + H2O <=> 3'-CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36859", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33086", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23951", "l": "4-hydroxybutanoate + NAD(+) <=> H(+) + NADH + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334794", "l": "FABPs bind LCFAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46398", "l": "an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23331", "l": "a 9-cis-epoxycarotenoid + O2 <=> 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38410", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621402", "l": "Defective CP does not oxidise Fe2+ to Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39859", "l": "a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871260", "l": "YAP1 binds TEAD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591086", "l": "SERPINA5 binds activated protein C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40886", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106309", "l": "progesterone 21-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:50304", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39635", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106145", "l": "scopoletin 8-hydroxylase activity", "d": ["Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114284", "l": "Release of Cytochrome c from mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12166", "l": "adenosine 3',5'-bisphosphate + an aryl sulfate + H(+) => 3'-phosphoadenylyl sulfate + a phenol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222363", "l": "MsrA/B reduces peptide-methionine S/R-sulfoxides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621270", "l": "FOXO1,FOXO3 bind PINK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052870", "l": "tocopherol omega-hydroxylase activity", "d": ["Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O ."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419644", "l": "Transphosphorylation of pLIMK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70715", "l": "glycine(in) = glycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36984", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.216", "l": "\"farnesol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693536", "l": "ATM phosphorylates MDC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53310", "l": "16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77227", "l": "AH2 + gentamicin X2 + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + geneticin + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11608", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA = [N,O(9)-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71288", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) => chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55404", "l": "[phosphate](n) + UTP = [phosphate](n+1) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647594", "l": "SAHF formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50881", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10038", "l": "H2O2 + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701556", "l": "IL2RG gene expression downstream of ALK signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75228", "l": "H2O + L-xylono-1,4-lactone => H(+) + L-xylonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14560", "l": "H2O + raucaffricine <=> D-glucose + vomilenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76967", "l": "a short-chain fatty aldehyde + H2O + NADP(+) = a short-chain fatty acid + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862771", "l": "PLA2G2A binds bacterial phospholipids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76885", "l": "4-hydroxybutan-2-one + H(+) + NADH + NH4(+) => 3-aminobutan-1-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61719", "l": "ATP + D-galactofuranose(out) + H2O <=> ADP + D-galactofuranose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51155", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176175", "l": "Stalling of DNA replication fork and RPA binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800794", "l": "PIDD1 associates with CRADD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74890", "l": "2',3'-cGAMP(in) + ATP + H2O <=> 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75646", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32612", "l": "(6E)-8-hydroxygeranial + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818937", "l": "MEN1 binds MLL1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70459", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52502", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30211", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide = 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": [], "t": []}, {"i": "EC:1.7.2.5", "l": "\"nitric-oxide reductase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55148", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68802", "l": "alpha-D-glucose + D-glucose => H2O + nigerose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028730", "l": "Activated NTRK2 binds FRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76628", "l": "(S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9817575", "l": "ERO1B oxidizes P4HB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53131", "l": "delta-carotene <=> epsilon-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0051903", "l": "S-(hydroxymethyl)glutathione dehydrogenase activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798353", "l": "E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16213", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.224", "l": "\"glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10768", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56938", "l": "testosterone => 17beta-hydroxy-androst-5-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25041", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": [], "t": []}, {"i": "EC:2.9.1.2", "l": "\"O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007882", "l": "IL1F10 is cleaved (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964284", "l": "BTK in active Gq-BTK complex is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167419", "l": "The receptor:G-protein complex releases GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35875", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0036318", "l": "peptide pheromone receptor activity", "d": ["Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41292", "l": "H2O + N-dodecanoylsphing-4-enine => dodecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163666", "l": "Formation of ChREBP:MLX heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28962", "l": "D-xylose(in) + H(+)(in) <=> D-xylose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77520", "l": "furfural + hydrogen cyanide => (2R)-2-(furan-2-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018826", "l": "RHOT2 hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754745", "l": "IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0031745", "l": "cysteinyl leukotriene receptor binding", "d": ["Binding to a cysteinyl leukotriene receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53307", "l": "AH2 + 2 ATP + 2 cob(II)alamin <=> A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53725", "l": "ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031679", "l": "NADH dehydrogenase (plastoquinone) activity", "d": ["Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71383", "l": "L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937869", "l": "RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748991", "l": "XDH oxidises 6MP to 6TU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24867", "l": "4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54950", "l": "(2E,5Z)-dodecadienoyl-[ACP] + H2O => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70674", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47416", "l": "an NDP-alpha-D-glucose + D-glucose = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21316", "l": "H2O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate", "d": [], "t": []}, {"i": "EC:3.1.1.51", "l": "\"phorbol-diester hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59188", "l": "L-histidine = D-histidine", "d": [], "t": []}, {"i": "EC:5.1.1.24", "l": "\"histidine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353481", "l": "5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27391", "l": "pyruvate + salicylaldehyde => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57320", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] = CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65977", "l": "7-dehydrocholesterol + hnu => previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052682", "l": "epi-cedrol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004495", "l": "mevaldate reductase activity", "d": ["Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72114", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) <=> L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20949", "l": "3-sulfopyruvate + H(+) => CO2 + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76411", "l": "2',3'-cGAMP(out) + n H(+)(out) = 2',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008043", "l": "MAPK8 phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46417", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35141", "l": "CO2 + 2 CoA + demethoxycurcumin => (E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14529", "l": "ADP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + phosphate", "d": [], "t": []}, {"i": "EC:2.7.7.35", "l": "\"ADP ribose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60191", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58066", "l": "5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070733", "l": "AMPylase activity", "d": ["Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41762", "l": "a ganglioside GD3 (d18:1(4E)) + CMP + H(+) => a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25479", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67603", "l": "H2O + O(6)-methyl-dGTP <=> diphosphate + H(+) + O(6)-methyl-dGMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61309", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17762", "l": "an aromatic primary alcohol + NADP(+) => an aromatic aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851866", "l": "MET binds RANBP10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102676", "l": "avenasterol-desaturase activity", "d": ["Catalysis of the reaction: avenasterol + O2 + NADPH + H+ = 5-dehydroavenasterol + 2 H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12721", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine", "d": [], "t": []}, {"i": "EC:2.5.1.16", "l": "\"spermidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928657", "l": "MMP2,9 cleave EPHB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47270", "l": "H2O + monoanhydrobacterioruberin => bacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14334", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209973", "l": "Tyrosine is diiodinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.68", "l": "\"geranyl diphosphate phosphohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114553", "l": "Activation of conventional Protein Kinase C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74294", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate <=> an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63841", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide => [thioredoxin]-disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17332", "l": "(1R,2S,4R)-borneol + NAD(+) <=> (1R,4R)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22846", "l": "glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032798", "l": "DOCK3 activates RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399939", "l": "Autophosphorylation of PAK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48933", "l": "a ganglioside GT1b + CMP-N-acetyl-beta-neuraminate => a ganglioside GQ1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392748", "l": "L1 binds to AP-2 Clathrin complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507869", "l": "Aquaporins passively transport glycerol into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103116", "l": "ABC-type D-galactofuranose transporter", "d": ["Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O = alpha-D-galactofuranose + hydrogenphosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68707", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) <=> 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51610", "l": "(R)-lactate + 2-oxoglutarate => (R)-2-hydroxyglutarate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29578", "l": "L-serine(in) + Na(+)(in) <=> L-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44858", "l": "CoA + O-(9Z)-octadecenoyl-(R)-carnitine => (9Z)-octadecenoyl-CoA + (R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40287", "l": "ATP + CoA + decanedioate = AMP + decanedioyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29116", "l": "H(+) + menaquinone-8 + NADPH => menaquinol-8 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005545", "l": "1-phosphatidylinositol binding", "d": ["Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357483", "l": "RAC1 binds PAK1-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55308", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050126", "l": "N-carbamoylputrescine amidase activity", "d": ["Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130706", "l": "MHC class II antigen processing (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693111", "l": "RHOF auto-activates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63084", "l": "chloride + FADH2 + ilicicolin B + O2 = FAD + H(+) + 2 H2O + ilicicolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636669", "l": "esxA binds ENO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001609", "l": "G protein-coupled adenosine receptor activity", "d": ["Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674095", "l": "PDGFRs bind type II TKI (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432148", "l": "Fgr may phosphorylate p38 MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55094", "l": "H(+) + sucrose + UDP => D-fructose + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50015", "l": "H(+) + NADPH + O2 + tert-butanol <=> 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31619", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.90", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681375", "l": "KIT binds ripretinib (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55742", "l": "D-glucose + oleuropein aglycone => H2O + oleuropein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38057", "l": "CDP + H(+) + phytyl phosphate => CTP + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55541", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] => 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168136", "l": "Activated JNKs phosphorylate c-JUN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77113", "l": "1D-myo-inositol 1,2,3,6-tetrakisphosphate + phosphate => 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22305", "l": "a ubiquinone + keto-D-fructose => 5-dehydro-D-fructose + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53770", "l": "allocholoyl-CoA + allodeoxycholate => allocholate + allodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22138", "l": "chlorophyllide b + 2 H2O + NADP(+) => 7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55446", "l": "cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45492", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49652", "l": "H(+) + NADH + O2 + protoviolaceinate = H2O + NAD(+) + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40775", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O = D-alpha-phenylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17701", "l": "ATP + geranoyl-CoA + hydrogencarbonate = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.5", "l": "\"geranoyl-CoA carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031278", "l": "alpha-1,2-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32603", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-oxogeraniol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26284", "l": "Co-precorrin-5A + H2O <=> acetaldehyde + Co-precorrin-5B + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65859", "l": "A + a 1-hydroxy-3-oxo steroid <=> a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46529", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044693", "l": "trehalose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74422", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64284", "l": "2-phenylethylamine + pyruvate = 2-phenylacetaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72455", "l": "fumarate(out) + 3 H(+)(out) = fumarate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21747", "l": "S-adenosyl-L-methionine <=> 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52083", "l": "12-octadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140756", "l": "structural constituent of proteasome", "d": ["The action of a molecule that contributes to the structural integrity of the proteasome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.47", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786118", "l": "IL13 binds IL13RA:TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34218", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) <=> 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73464", "l": "carcinine + H2O => beta-alanine + histamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093342", "l": "SDC2 multimerises (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13161", "l": "L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.103", "l": "\"L-threonine 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76031", "l": "2 H2O2 => O2 + 2 H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15297", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.133", "l": "\"xylosylprotein 4-beta-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37612", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727607", "l": "MME:Zn2+ binds sacubitrilat (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052631", "l": "sphingolipid delta-8 desaturase activity", "d": ["Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182876", "l": "Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45203", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3878123", "l": "Initiation of SAHF formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698928", "l": "Late (L) Gene Expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748996", "l": "GST dimers cleave AZA to 6MP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912680", "l": "Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64101", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69685", "l": "CHEK2 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64857", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + phomopsene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29683", "l": "alpha-maltohexaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022886", "l": "channel-forming ionophore activity", "d": ["Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24110", "l": "2-oxoglutarate + methylamine => H2O + N-methyl-2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14119", "l": "[(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55989", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229132", "l": "AP4 binds APP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58069", "l": "(E)-isoeugenol + O2 => acetaldehyde + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55195", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 <=> 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23410", "l": "2 H(+) + NADPH + precorrin-6A => NADP(+) + precorrin-6B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26076", "l": "H2O + UDP-alpha-D-glucuronate <=> D-glucuronate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2059926", "l": "NPHP4 protein binds LATS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30327", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63643", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) <=> 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22922", "l": "1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate => L-glutamine + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420980", "l": "Activation of Ca permeable AMPA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371353", "l": "Soluble TNF-α binds TNFR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783332", "l": "APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41036", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9703895", "l": "CASR binds CASR agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0000014", "l": "single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39863", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66338", "l": "L-glutamate(in) => L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70016", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone => 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004059", "l": "aralkylamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52307", "l": "H2O + L-ectoine <=> (2S)-2-acetamido-4-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63690", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47687", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate <=> [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56419", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> alpha-D-glucose 1-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008117", "l": "sphinganine-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176445", "l": "SMURF2 binds SMAD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71149", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => 3-hydroxyhispidin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60119", "l": "2-oxoglutarate + methylphosphonate + O2 <=> CO2 + hydroxymethylphosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51672", "l": "glyoxal + H2O = glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76146", "l": "picrinine + S-adenosyl-L-methionine <=> ervincine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29693", "l": "alpha-D-glucose 1-phosphate + alpha-maltotriose => alpha-maltotetraose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000513", "l": "actin severing activator activity", "d": ["Binds to and increases the activity of a actin severing protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732527", "l": "FFAR1 binds rosiglitazone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18045", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O = alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.51", "l": "\"glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001068", "l": "transcription regulatory region RNA binding", "d": ["Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734730", "l": "ORC1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.44", "l": "\"nuclear-inclusion-a endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72116", "l": "glycine betaine(out) + Na(+)(out) => glycine betaine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18157", "l": "ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33866", "l": "menaquinone-7 + succinate <=> fumarate + menaquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870466", "l": "RGGT:CHM binds RABs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72799", "l": "L-arginine(out) + L-homoarginine(in) = L-arginine(in) + L-homoarginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35638", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30757", "l": "ADP + carbamoyl phosphate => ATP + carbamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54715", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14399", "l": "(4Z)-2-oxohept-4-enedioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28819", "l": "5-dehydro-D-gluconate(in) + H(+)(in) = 5-dehydro-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20268", "l": "2-oxoglutarate + L-proline + O2 <=> cis-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73768", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate => diphosphate + preechinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952371", "l": "MDM2 binds RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035517", "l": "Defective AVP mutants do not bind AVPR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948034", "l": "FGR binds LDL:LRP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48542", "l": "dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) => 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48792", "l": "GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18995", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50673", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O => [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58859", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-oxogeraniol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.16", "l": "\"3-carboxyethylcatechol 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004074", "l": "biliverdin reductase (NAD(P)+) activity", "d": ["Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0044689", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity", "d": ["Catalysis of the reaction: 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H+ + L-methionine + NH4+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49565", "l": "D-sedoheptulose 7-phosphate => 2-epi-valiolone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42529", "l": "uridine(955/2504/2580) in 23S rRNA => pseudouridine(955/2504/2580) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004945", "l": "angiotensin type II receptor activity", "d": ["An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034387", "l": "4-aminobutyrate:pyruvate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53193", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68133", "l": "phytol + tetradecanoyl-CoA => CoA + tetradecanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56963", "l": "a ribonucleoside 5'-triphosphate + pyruvate <=> a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0051920", "l": "peroxiredoxin activity", "d": ["Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12373", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O => 4-oxohex-2-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481009", "l": "Exocytosis of platelet dense granule content (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33184", "l": "citrate(in) => citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654409", "l": "Activated FGFR3 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.21", "l": "\"astacin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205238", "l": "SHP2 interacts with p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70515", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015592", "l": "methylgalactoside transmembrane transporter activity", "d": ["Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757686", "l": "SERPINA6 binds PREDL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49891", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15481", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": [], "t": []}, {"i": "EC:2.1.2.1", "l": "\"glycine hydroxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77122", "l": "1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,2,6-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14428", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53571", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19794", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653893", "l": "ATF4, CEBPB, and ATF3 bind the CHAC1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830872", "l": "G is N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008200", "l": "NFE2 binds the beta globin locus control region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791088", "l": "Expression of GFPT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38167", "l": "hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617182", "l": "PRKACA phosphorylates PLN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19165", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.208", "l": "\"diglucosyl diacylglycerol synthase (1,2-linking)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53692", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030266", "l": "quinate 3-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34530", "l": "L-phenylalanine <=> (S)-3-amino-3-phenylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665304", "l": "ERBB2 T862A does not bind sapitinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67013", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050255", "l": "ribitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132210", "l": "C3b fragment binds to the target cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45295", "l": "2-glyceryl-prostaglandin G2 + AH2 <=> 2-glyceryl-prostaglandin H2 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061608", "l": "nuclear import signal receptor activity", "d": ["Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43409", "l": "sphinganine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11427", "l": "ATP + L-threonyl-[myosin heavy-chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33349", "l": "glyoxylate + NH4(+) => 2-iminoacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17919", "l": "[Glu(-Cys)](n+1)-Gly + glycine => [Glu(-Cys)](n)-Gly + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44813", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40732", "l": "(20S)-ginsenoside Rg3 + 2 H2O => (20S)-protopanaxadiol + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47636", "l": "H2O + L-arginine + NADP(+) = 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20650", "l": "23,24-dihydrocucurbitacin B + NADP(+) => cucurbitacin B + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14694", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849085", "l": "ARHGAP35 binds RHOA:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980118", "l": "ARRB mediates NOTCH1 ubiquitination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41040", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609921", "l": "SGTA binds Tail-anchored protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166387", "l": "The FA anion diffuses away laterally from UCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001223", "l": "transcription coactivator binding", "d": ["Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35373", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate => 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186798", "l": "GAP binds to PDGF-beta receptors only (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67973", "l": "ATP + ecdysone => ADP + ecdysone 22-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47561", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53503", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5195402", "l": "CDK1 phosphorylates LPIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.25", "l": "\"beta-peptidyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62081", "l": "D-glucose 6-sulfate + NADP(+) => 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196857", "l": "PANK2 phosphorylates PanK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.2", "l": "\"peptidyl-glycinamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64374", "l": "alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18287", "l": "a carboxylate + D-aspartate => an N-acyl-D-aspartate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222093", "l": "BRD7 binds TP53 and EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-451033", "l": "(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70865", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(in) => L-glutamine(out) + L-threonine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613648", "l": "SOX10 dimer binds the POU3F1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828725", "l": "M mRNA is translated into protein M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27644", "l": "adenine + alpha-D-ribose 1-phosphate => adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684018", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933533", "l": "Dimerization of p-IRF7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19571", "l": "5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936380", "l": "Interaction of PIN1 with p-IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35407", "l": "H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50817", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => 5alpha-androstan-3,17-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032216", "l": "glucosaminyl-phosphatidylinositol O-acyltransferase activity", "d": ["Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632412", "l": "PTK2 is recruited to methylated ESR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50434", "l": "A + H2O + prostaglandin H1 => AH2 + prostaglandin G1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12121", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) => ADP-alpha-D-glucose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802924", "l": "RAF is phosphorylated downstream of oncogenic RAS  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71303", "l": "RPE dimers isomerise RU5P to XY5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944216", "l": "Association of procollagen type XV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17623", "l": "(3S)-citramalyl-CoA + acetate => acetyl-CoA + citramalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65348", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA = 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76426", "l": "(8S)-annullatin E + dimethylallyl diphosphate <=> (8S)-annullatin J + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10356", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-dione + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.152", "l": "\"3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50387", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57149", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481010", "l": "Surface deployment of platelet dense granule membrane components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12220", "l": "H2O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.9", "l": "\"leucine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683831", "l": "CCDC59 binds TTF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58155", "l": "H2O + NAD(+) + phosphonoacetaldehyde <=> 2 H(+) + NADH + phosphonoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45698", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(out) => N-(acetyl)-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018784", "l": "(S)-2-haloacid dehalogenase activity", "d": ["Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33316", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15692", "l": "H(+) + L-2,4-diaminobutanoate <=> CO2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73018", "l": "D-leucine(in) <=> D-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23055", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12984", "l": "H2O + O2 + S-sulfanylglutathione <=> glutathione + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37708", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36284", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 => 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73491", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) = Co(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047388", "l": "[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase activity", "d": ["Catalysis of the reaction: [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429157", "l": "ABCC4 accumulation of dense granule contents (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64687", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14368", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate <=> CO2 + L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030550", "l": "acetylcholine receptor inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an acetylcholine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47247", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033702", "l": "(+)-trans-carveol dehydrogenase activity", "d": ["Catalysis of the reaction: (1R,5S)-carveol + NAD+ = (S)-carvone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944232", "l": "Association of procollagen type XII (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24382", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet) => (6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27421", "l": "(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.46", "l": "\"alpha-farnesene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193996", "l": "11DCORST translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32771", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate = 2,6-dioxo-6-phenylhexa-3-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13922", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44289", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13380", "l": "alpha-D-glucose 1-phosphate + ATP <=> ADP + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17266", "l": "trans-aconitate => cis-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791348", "l": "TP53 stimulates APAF1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26314", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.120", "l": "\"L-fucono-1,5-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432143", "l": "PECAM-1 binds PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52803", "l": "acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805122", "l": "AURKB binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.245", "l": "\"alpha,alpha-trehalose synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25701", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54097", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12277", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70191", "l": "ATP + NAD(+) = 3'-NADP(+) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681840", "l": "RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14716", "l": "A + keto-L-sorbose <=> 5-dehydro-D-fructose + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14908", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061898", "l": "all-trans retinoic acid 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinoic acid + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54431", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64836", "l": "2-phenylethanol + acetyl-CoA = CoA + phenethyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54776", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021050", "l": "HSBP1 oligomer binds ESRs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68184", "l": "a medium-chain fatty acyl-CoA + H2O = a medium chain fatty acid + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.19", "l": "\"ADP-dependent medium-chain-acyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53756", "l": "allodeoxycholoyl-CoA + cholate = allodeoxycholate + choloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191072", "l": "Synthesis of Cx43 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37303", "l": "ATP + glycyl-L-asparagine(out) + H2O = ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985153", "l": "OASL binds DDX58 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38176", "l": "all-trans-retinol + hexadecanoyl-CoA => all-trans-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22768", "l": "4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": [], "t": []}, {"i": "EC:4.3.3.1", "l": "\"3-ketovalidoxylamine C-N-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54016", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199910", "l": "MSK1 activates ATF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018718", "l": "1,2-dihydroxy-phenanthrene glycosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.19", "l": "\"(R)-specific secondary-alkylsulfatase (type III)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14846", "l": "L-aspartate 4-semialdehyde + pyruvate => (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647631", "l": "GSDMD (1-275) binds PIPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65047", "l": "4-cyanobenzyl alcohol + NAD(+) <=> 4-cyanobenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32169", "l": "aerobactin + AMP + diphosphate + H(+) => ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67525", "l": "4,8-dimethylnonanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706354", "l": "Ubiquitination of FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67621", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76000", "l": "glutarate(in) + kynurenate(out) => glutarate(out) + kynurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450533", "l": "PKCdelta phosphorylates HuR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27725", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose <=> 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749590", "l": "ASA- acetylates ALB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41659", "l": "dihydrosanguinarine + NADP(+) <=> NADPH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50243", "l": "[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008138", "l": "protein tyrosine/serine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33249", "l": "1-pyrroline + H2O2 + NH4(+) => O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35074", "l": "4-methylphenol(in) <=> 4-methylphenol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786650", "l": "DDHD1,2 hydrolyse PA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30086", "l": "4 Cu(+) + 4 H(+) + O2 <=> 4 Cu(2+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76803", "l": "2-aminopentan-1-ol + H2O + NAD(+) = 1-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61691", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine <=> AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10401", "l": "L-glutamine + pyruvate => 2-oxoglutaramate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173723", "l": "C8 binds C5b:C6:C7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55791", "l": "acetone + H(+) + NADH + O2 <=> H2O + hydroxyacetone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67734", "l": "a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA => uridylyl-uridylyl-ribonucleotide-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-901047", "l": "Binding of ERp57 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12771", "l": "2-dehydro-D-gluconate + AH2 => A + D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67361", "l": "H2O + L-threonyl-L-threonine => 2 L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45941", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102233", "l": "crotonaldehyde redutase activity", "d": ["Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ = butanal + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60224", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.68", "l": "\"[histone H3]-trimethyl-L-lysine(27) demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395364", "l": "LTBP4 binds TGF-Beta-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213200", "l": "Release of endostatin-like peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237160", "l": "MTA is cleaved and phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033286", "l": "ATPase-coupled ectoine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)."], "t": []}, {"i": "RHEA:32787", "l": "ATP + H2O + L-ectoine(out) = ADP + H(+) + L-ectoine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66311", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63521", "l": "2-isopropylphenol + H(+) + NADH + O2 => 3-isopropylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53523", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65618", "l": "25-hydroxycholest-4-en-3-one + AH2 => A + cholest-4-en-3-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51037", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => 2 H2O + indole-3-pyruvate imine dimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019977", "l": "interleukin-21 binding", "d": ["Binding to interleukin-21."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9733973", "l": "Bile salts bind FABP6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70216", "l": "cortisol + H(+) + NADPH => 20beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41176", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) => methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803978", "l": "S-nitrosylation of cysteine residues in proteins by N2O3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004666", "l": "prostaglandin-endoperoxide synthase activity", "d": ["Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417825", "l": "P2Y11 receptor can bind to ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44191", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65572", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25584", "l": "alpha-L-rhamnose = beta-L-rhamnose", "d": [], "t": []}, {"i": "EC:5.1.3.32", "l": "\"L-rhamnose mutarotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373717", "l": "DCC interacts with DIP13alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61574", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380782", "l": "STAT binds to the active receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47414", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73379", "l": "(R)-lipoate(out) + 2 Na(+)(out) = (R)-lipoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31827", "l": "(2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.92", "l": "\"(+)-gamma-cadinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14797", "l": "2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.5.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53971", "l": "apo-[BtrI ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30473", "l": "(1S,5S,6S)-alpha-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33574", "l": "A + methanol <=> AH2 + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62084", "l": "ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418091", "l": "F2R binds ARRB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16556", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74491", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10463", "l": "prostaglandin A1 <=> prostaglandin C1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73773", "l": "H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase] => O2 + preechinulin + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12916", "l": "(R)-lipoate + ATP + H(+) <=> (R)-lipoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2203516", "l": "Alpha-1-Microglobulin is cleaved (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684030", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.-", "l": "\"Methylenetransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694428", "l": "LMAN family proteins bind glycosylated cargo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984226", "l": "PLK1 phosphorylates NEK9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62697", "l": "O2 + 4 tellimagrandin II => 2 cornusiin E + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53377", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) => H(+) + NADPH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62225", "l": "H(+) + NADPH + neopatulin => (E)-ascladiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022365", "l": "GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218812", "l": "FYN phosphorylates PAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48864", "l": "2-methylpropan-1-amine + FADH2 + O2 = FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28676", "l": "alpha-D-galactose => beta-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10748", "l": "H(+) + hydrogencarbonate = CO2 + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.1", "l": "\"carbonic anhydrase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448629", "l": "IL33 binds IL1RL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864431", "l": "TFAP2A,TFAP2C homodimers stimulate CGB3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062241", "l": "double strand break-nuclear membrane anchor activity", "d": ["Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51602", "l": "3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44489", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465924", "l": "OPN1LW binds 11cRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640114", "l": "Misfolded proteins translocate from cilium to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59570", "l": "ADP + H(+) + L-homocarnosine + phosphate => 4-aminobutanoate + ATP + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202164", "l": "Translocation of PDK1 to Plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9819200", "l": "ZFP36L2 binds CNOT6L of CCR4-CNOT complex and an AU-rich element in mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023031", "l": "MHC class Ib protein binding, via lateral surface", "d": ["Binding to a major histocompatibility complex class Ib molecules via the lateral surface."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209566", "l": "TRAF6 is auto-ubiquitinated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.148", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31502", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71235", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57110", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18294", "l": "ATP + CoA + oxalate => AMP + diphosphate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17348", "l": "(S)-methylmalonyl-CoA + H2O <=> CoA + H(+) + methylmalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25823", "l": "H2O + O2 + spermidine <=> 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71225", "l": "chloride(in) + 2 Na(+)(in) + taurine(in) => chloride(out) + 2 Na(+)(out) + taurine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10053", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35837", "l": "kanamycin A + NADP(+) => 2'-dehydrokanamycin A + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60256", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21689", "l": "a polyvinyl alcohol + n O2 => an oxidized polyvinyl alcohol + n H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612440", "l": "ERBB4s80 binds the MXD4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28923", "l": "H(+)(in) + L-phenylalanine(in) = H(+)(out) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77247", "l": "H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.52", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015167", "l": "arabitol transmembrane transporter activity", "d": ["Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65464", "l": "2-methylbutan-1-ol + butanoyl-CoA = 2-methylbutyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811412", "l": "Active ARF recruits coatomer to the Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202443", "l": "Oligomerization of CARMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19750", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193702", "l": "Part of the ICD migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66098", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73925", "l": "griseophenone D + H(+) + S-adenosyl-L-homocysteine => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102470", "l": "6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose = 6C-glucosyl-2-hydroxynaringenin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52276", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650858", "l": "Meglitinides bind ABCC8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730847", "l": "Hydrolysis of PIP2 by PLCG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050897", "l": "cobalt ion binding", "d": ["Binding to a cobalt ion (Co)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390154", "l": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979071", "l": "KDM6B binds iron (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37022", "l": "A + D-serine + H2O <=> 3-hydroxypyruvate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49121", "l": "H(+) + NADPH + O2 + protoviolaceinate => H2O + NADP(+) + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810076", "l": "DDO oxidizes D-Asp to OA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867047", "l": "PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22402", "l": "17beta-hydroxyandrostanone + H(+) + NADH => androstan-3alpha,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62485", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32560", "l": "(2E)-geranyl diphosphate => diphosphate + gamma-terpinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944247", "l": "Association of procollagen type VI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0048763", "l": "calcium-induced calcium release activity", "d": ["Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196753", "l": "2xPPCS ligates PPanK with Cys (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15301", "l": "D-apiitol + NAD(+) = aldehydo-D-apiose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.114", "l": "\"apiose 1-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42942", "l": "5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA precursor + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102599", "l": "cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-beta-amyrin + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450550", "l": "PKCalpha phosphorylates HuR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9678925", "l": "NR3C1 binds NR3C1 agonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35366", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH <=> isopentadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32506", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615801", "l": "MECP2 binds IRAK1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.79", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41117", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62859", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.159", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16873", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199203", "l": "PANK1/3 phosphorylate PanK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29771", "l": "arsenate(in) + ATP + H2O = ADP + arsenate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55810", "l": "a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O => a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68885", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH => 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54465", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70498", "l": "D-glucose(out) + 2 Na(+)(out) <=> D-glucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13767", "l": "bromide + chloride + formaldehyde + 2 H(+) => bromochloromethane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32916", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) => sn-glycero-3-phospho-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21449", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] => 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64117", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0000257", "l": "nitrilase activity", "d": ["Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71783", "l": "MDH2 reduces OA to MAL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201457", "l": "BMP2 binds to the receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46227", "l": "(E)-feruloyl-CoA + H2O <=> (E)-ferulate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34822", "l": "dihydrocurcumin + NADP(+) <=> curcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099184", "l": "structural constituent of postsynaptic intermediate filament cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13973", "l": "diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate", "d": [], "t": []}, {"i": "EC:7.1.3.1", "l": "\"H(+)-exporting diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47629", "l": "glyoxylate + H2O + propanoyl-CoA => 3-methylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68564", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204549", "l": "Caveolin-1 binds Basigin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16842", "l": "precorrin-2 + S-adenosyl-L-methionine => H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16132", "l": "NADP(+) + pyridoxine <=> H(+) + NADPH + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65784", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50257", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71330", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) <=> chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218812", "l": "FYN phosphorylates PAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949145", "l": "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936563", "l": "ISGylation of DDX58 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0005504", "l": "fatty acid binding", "d": ["Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61147", "l": "myricetin + UDP-beta-L-rhamnose <=> H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39645", "l": "(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33539", "l": "ergosteryl ester + H2O = a carboxylate + ergosterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034562", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity", "d": ["Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16283", "l": "ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+) => ATP + dihydrostreptomycin 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61445", "l": "a tetracycline + H(+) + NADPH + O2 => an 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30433", "l": "taraxerol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57084", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757688", "l": "SERPINA6 binds PREDN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851979", "l": "BTNL9 binds immune cell surfaces (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45905", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + epivancomycin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47571", "l": "a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose <=> a ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74733", "l": "Insulin receptor de-phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50395", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline <=> 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350598", "l": "Arginine<=>Agmatine+CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450187", "l": "TAK1 is activated within the TAK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59013", "l": "cycloartenol + S-adenosyl-L-methionine => 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37077", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39927", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013143", "l": "RAC1 GEFs activate RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24562", "l": "CoA + O-acetyl-L-serine => acetyl-CoA + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990890", "l": "netrin receptor binding", "d": ["Binding to a netrin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56028", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13874", "l": "(+)-copalyl diphosphate => abieta-7,13-diene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433456", "l": "Recruitment of STATs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928604", "l": "SFKs phosphorylate VAV2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33016", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 => [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004072", "l": "aspartate kinase activity", "d": ["Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788622", "l": "p-Y-STATs dimerize (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30406", "l": "Fe(3+)(out) + L-ascorbate(in) <=> Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67493", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42292", "l": "a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.274", "l": "\"phosphate acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24114", "l": "glutathione disulfide + H2O2 => 2 glutathione + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798474", "l": "S100A8:S100A9 binds Zn2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706344", "l": "FLT3 phosphorylates GRB10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36358", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46580", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 = 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161293", "l": "Tropoelastin forms aggregate globules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10163", "l": "L-iditol + NAD(+) <=> H(+) + keto-L-sorbose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62563", "l": "(4R)-limonene + A + H2O <=> (4R)-perillyl alcohol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61699", "l": "ATP + glycine + holo-[peptidyl-carrier protein] <=> AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201443", "l": "Type II receptor phosphorylates type I receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33572", "l": "A + methanol => AH2 + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429157", "l": "ABCC4 accumulation of dense granule contents (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66690", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41648", "l": "aniline + ATP + L-glutamate = ADP + N(5)-phenyl-L-glutamine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.18", "l": "\"gamma-glutamylanilide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77509", "l": "(2S,3E)-2-hydroxy-4-phenylbut-3-enenitrile => (E)-cinnamaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68762", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine => 3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790036", "l": "Expression of STAT3-upregulated nuclear proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698013", "l": "PTPN11:p-STAT5 dissociates from mutant FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62406", "l": "CO2 + H2O + pentadecanoate => (R)-2-hydroxyhexadecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482770", "l": "Release of platelet secretory granule components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648017", "l": "EML4 binds to microtubules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709454", "l": "EPOR binds EPOR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202731", "l": "JAM3 dimerises (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862184", "l": "USP48 cleaves polyubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10548", "l": "L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.13.12.1", "l": "\"arginine 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562604", "l": "BfrA stores iron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25538", "l": "diphosphate + ent-sandaracopimara-8(14),15-diene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71083", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77398", "l": "hydrogen cyanide + propanal <=> (2S)-2-hydroxybutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69806", "l": "ATP + benzoate + H(+) <=> benzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209903", "l": "Noradrenaline is converted to adrenaline (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050299", "l": "streptomycin 3''-kinase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 3''-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40821", "l": "(9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20135", "l": "H(+) + indole-3-pyruvate + NADH => 3-(indol-3-yl)lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24931", "l": "H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17436", "l": "A + choline <=> AH2 + betaine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024361", "l": "Expression of ABCG1 regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11281", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662986", "l": "MT2A binds copper (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34109", "l": "1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA => glycine + H(+) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445064", "l": "Activation of Rac1 by VAV2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21323", "l": "A + D-sorbitol <=> AH2 + keto-L-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33556", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O => (4R)-hydroxysphinganine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59591", "l": "ATP + beta-alanine + L-ornithine <=> ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796075", "l": "NFE2L2 dependent SOD3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32907", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042924", "l": "neuromedin U binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602473", "l": "Autocatalytic activation of MMP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047847", "l": "deoxyuridine phosphorylase activity", "d": ["Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52786", "l": "A + ergothioneine + H2O => 2-sulfenohercynine + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33252", "l": "2 sucrose => 6-kestotriose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62733", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53242", "l": "cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25977", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25498", "l": "(1S,5S)-beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140950", "l": "histone H2A deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854052", "l": "Formation of the SCF-FBXL7 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58018", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26442", "l": "a ubiquinone + ethanol = a ubiquinol + acetaldehyde", "d": [], "t": []}, {"i": "EC:1.1.5.5", "l": "\"alcohol dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684006", "l": "KPNA2 translocates NBN to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433593", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12211", "l": "4-methylumbelliferyl acetate + H2O <=> 4-methylumbelliferone + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52811", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030739", "l": "O-demethylpuromycin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45356", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine = (11Z)-eicosenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60037", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate => 3-hydroxy-3-methylhexanoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080017", "l": "alpha-humulene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55852", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16781", "l": "a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.20", "l": "\"acyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61662", "l": "(2E)-geranyl phosphate + ADP + H(+) => (2E)-geraniol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32090", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate <=> [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66830", "l": "2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48349", "l": "a uridine in RNA => a pseudouridine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807872", "l": "Active ARF recruits coatomer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18314", "l": "(R)-mandelonitrile => benzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15504", "l": "2 L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22048", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.12", "l": "\"6-pyruvoyltetrahydropterin synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64423", "l": "H(+)(out) + L-alanyl-L-proline(out) <=> H(+)(in) + L-alanyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954185", "l": "ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683964", "l": "ATM phosphorylates EYA1-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17652", "l": "acetyl-[ACP] + malonate <=> acetate + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69644", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 => (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34090", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517850", "l": "TLR2-1 : TLR1-2 heterodimer binds to its ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944261", "l": "Association of procollagen type XIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132260", "l": "Complement factor I inactivates surface-bound C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30451", "l": "(S)-2,3-epoxysqualene = isomultiflorenol", "d": [], "t": []}, {"i": "EC:5.4.99.36", "l": "\"isomultiflorenol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42495", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 <=> 3'-N-debenzoyltaxol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71548", "l": "5-phosphomethyl-dUMP in DNA + glycine => 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32777", "l": "(2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate => (2-aminoethyl)phosphonate(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62207", "l": "1-propanol + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33365", "l": "D-mannitol 1-phosphate(in) + L-histidyl-[protein] => D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016403", "l": "dimethylargininase activity", "d": ["Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73727", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate = (2S,3R,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35971", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate = diphosphate + fumitremorgin B", "d": [], "t": []}, {"i": "EC:2.5.1.110", "l": "\"12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55260", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41298", "l": "H2O + N-(hexanoyl)sphing-4-enine <=> hexanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72395", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14090", "l": "2-oxoglutarate + glycine => glyoxylate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73892", "l": "MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28447", "l": "1-deoxy-D-xylulose(in) => 1-deoxy-D-xylulose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + rhizathalene A", "d": [], "t": []}, {"i": "EC:4.2.3.195", "l": "\"rhizathalene A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757688", "l": "SERPINA6 binds PREDN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13880", "l": "a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40768", "l": "(20S)-ginsenoside R1 + H2O => (20S)-ginsenoside Rg1 + D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75115", "l": "all-trans-13,14-dihydroretinol + NAD(+) = all-trans-13,14-dihydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61280", "l": "4-aminobutanoate + H2O + O2 = H2O2 + NH4(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61471", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661745", "l": "An unknown BILR reduces BIL to D-UBGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41691", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24954", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004412", "l": "homoserine dehydrogenase activity", "d": ["Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16298", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34727", "l": "H2O + N-acyl-15-methylhexadecasphinganine = 15-methylhexadecasphinganine + a carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102165", "l": "(Z)-3-hexen-1-ol acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol = (3Z)-hex-3-en-1-yl acetate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755545", "l": "Defective DHDDS does not elongate E,E-FPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76474", "l": "AH2 + cob(III)alamin <=> A + cob(I)alamin + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043888", "l": "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity", "d": ["Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55314", "l": "1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616241", "l": "CEBPA binds the promoter of the CEBPE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36947", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679101", "l": "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48182", "l": "(2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17963", "l": "H2O + leukotriene A4 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24604", "l": "7-methylxanthine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58369", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) => (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795460", "l": "SGK1 phosphorylates MDM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866304", "l": "pre-VLDL binds lipids to form VLDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43483", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10510", "l": "aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21437", "l": "[translation elongation factor 2] + ATP => [translation elongation factor 2]-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392513", "l": "Rap1 signal termination by Rap1GAPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847880", "l": "CYTH proteins bind ARF1:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38884", "l": "a fatty acid + ATP + CoA => a fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676229", "l": "WIPIs bind PI3P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624112", "l": "CEBPA binds CDK4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13778", "l": "ATP + D-ribose 5-phosphate + NH4(+) => 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10304", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.40", "l": "\"acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42723", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA <=> 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60941", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58038", "l": "8-epi-inunolide + H2O => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050556", "l": "deacetylisoipecoside synthase activity", "d": ["Catalysis of the reaction: deacetylisoipecoside + H2O = dopamine + secologanin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18781", "l": "H(+) + malonyl-CoA = acetyl-CoA + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.9", "l": "\"malonyl-CoA decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54084", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine = archaeosine(15) in tRNA + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.97", "l": "\"archaeosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027670", "l": "ESTG binding induces ESR depalmitoylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034542", "l": "trimethylarsine oxidase activity", "d": ["Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63925", "l": "ATP + N(4)-acetylcytidine => ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56950", "l": "H(+) + phosphoenolpyruvate + UDP => pyruvate + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41521", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112604", "l": "Phosphorylated STATs are released (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58792", "l": "ATP + Fe(III)-petrobactin(out) + H2O = ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72249", "l": "(R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49179", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59202", "l": "diphosphate + docosanoyl-AMP => ATP + docosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57967", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10719", "l": "D-glucose 6-phosphate <=> 1D-myo-inositol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15725", "l": "1,5-anhydro-D-fructose = ascopyrone M + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.111", "l": "\"1,5-anhydro-D-fructose dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008502", "l": "melatonin receptor activity", "d": ["Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31392", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) => all-trans-4,4'-diapolycopene + 4 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10168", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.2", "l": "\"15,16-dihydrobiliverdin:ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21782", "l": "AH2 + cyclohex-2-enone => A + cyclohexanone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68345", "l": "ATP + GTP => 3',2'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797100", "l": "CCNK binds CDK13 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36446", "l": "dihydrochanoclavine-I aldehyde <=> 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74584", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] => N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68912", "l": "ATP + H(+) + NADPH + propanoate = AMP + diphosphate + NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849882", "l": "SALMs 1-4 bind reticulon 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018789", "l": "cyclamate sulfohydrolase activity", "d": ["Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47263", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784189", "l": "JAKs bind LIFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640167", "l": "RRAGA,B exchanges GDP for GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70112", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59739", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA <=> CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864729", "l": "PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59978", "l": "CO2 + toluene => 2-phenylacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49638", "l": "H(+) + H2O2 + pyruvate => H2O + methylglyoxal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449818", "l": "IL13 binds IL13RA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71358", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) <=> 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34338", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56571", "l": "a globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70022", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol <=> 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392748", "l": "L1 binds to AP-2 Clathrin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10731", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55229", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40690", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol <=> 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12325", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => L-asparagine + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34111", "l": "carboxyspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59302", "l": "adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly D-luciferin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62917", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine => an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46258", "l": "a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685319", "l": "CX3 complex formation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74735", "l": "S-adenosyl-L-methionine + syringetin = 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58696", "l": "NADPH + O2 + rifampicin = H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985343", "l": "RUNX2 binds SOX9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76232", "l": "2-oxoglutarate(in) => 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38292", "l": "(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22300", "l": "a flavonol + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.91", "l": "\"flavonol 3-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001164", "l": "RNA polymerase I core promoter sequence-specific DNA binding", "d": ["Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10493", "l": "H2O + phosphocholine => choline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53298", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54028", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132278", "l": "Cleavage of C5 by C5 convertases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13398", "l": "6-oxohexanoate + H2O + NADP(+) => 2 H(+) + hexanedioate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255342", "l": "RALA exchanges GDP for GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74698", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] <=> (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177479", "l": "Axonal transport of NGF:Trk complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44176", "l": "a 2,3-diacyl-sn-glycerol + H2O = a 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36228", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54194", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69441", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28613", "l": "H2O + XTP <=> diphosphate + H(+) + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015111", "l": "Factor Xa inhibitors binds Xa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67583", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate <=> adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77084", "l": "O2 + pre-flavunoidine + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-pre-flavunoidine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17992", "l": "ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46526", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17744", "l": "NAD(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27476", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate <=> ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13131", "l": "4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP => cis-4-coumarate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211960", "l": "CYP2U1 19-hydroxylates ARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168951", "l": "TLR1:TLR2 is recruited to ligand:CD14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166753", "l": "Conversion of C4 into C4a and C4b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71444", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) => 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050313", "l": "sulfur dioxygenase activity", "d": ["Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371435", "l": "Constitutive phosphorylation by GSK3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641147", "l": "DACT1 binds DVL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9010815", "l": "SLITs bind keratan sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33968", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O => 3-maleylpyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72498", "l": "glutarate(in) + prostaglandin E2(out) <=> glutarate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26073", "l": "H2O + UDP-alpha-D-glucuronate = D-glucuronate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0019975", "l": "interleukin-17 binding", "d": ["Binding to a member of the interleukin-17 family of cytokines."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373722", "l": "Nephrin binds CASK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52751", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O <=> 2 isomaltose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848370", "l": "IL18 binds IL18R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17968", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) <=> (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23690", "l": "hypoxanthine + NH4(+) => adenine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53954", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate => 4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388560", "l": "EDNRA,EDNRB bind EDNs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863973", "l": "Fusion of ERC and phagosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139898", "l": "Caspase-8 activates BID by cleavage (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213464", "l": "RIPK1 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75528", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 => benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22479", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071522", "l": "ureidoglycine aminohydrolase activity", "d": ["Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55658", "l": "a carotenoid chi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170986", "l": "Ral-GDS binds to Ras-GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5140741", "l": "WNT5A binds FZD and ROR receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71026", "l": "L-leucine(in) + L-phenylalanine(out) <=> L-leucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51158", "l": "AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Glu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38395", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010280", "l": "UDP-L-rhamnose synthase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416562", "l": "p190RhoGAP binds Plexin-B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728150", "l": "SLC5A2 binds gliflozins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70187", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose = cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688834", "l": "ATXN3 binds VCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030354", "l": "melanin-concentrating hormone activity", "d": ["The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32580", "l": "(2E)-geranyl diphosphate => (1R,5R)-beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429730", "l": "PPM1L dephosphorylates multiphospho-CERT1-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029272", "l": "Release of PLCG from FCGR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848586", "l": "Transport of cytosolic HXOL to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16661", "l": "fluoride + S-adenosyl-L-methionine = 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.63", "l": "\"adenosyl-fluoride synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53608", "l": "4-hydroxyestrone + O2 = (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25358", "l": "2-hydroxyphytanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809680", "l": "MTMR12 binds MTM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008879", "l": "glucose-1-phosphate thymidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9035227", "l": "TXN2 binds CysS248-MPST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48544", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.233", "l": "\"[phosphatase 2A protein]-leucine-carboxy methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48707", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51932", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite = 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": [], "t": []}, {"i": "EC:1.8.2.5", "l": "\"thiosulfate reductase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000994", "l": "RNA polymerase III core binding", "d": ["Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16482", "l": "3 S-adenosyl-L-methionine => 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102849", "l": "1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40651", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24788", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54185", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O => a carboxylate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203613", "l": "depalmitoylation of eNOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52639", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 <=> a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936851", "l": "AHRR binds ARNT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53584", "l": "NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39181", "l": "eicosanoyl-CoA + NADP(+) => (2E)-eicosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46828", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14123", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44720", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55282", "l": "13-cis-retinyl tetradecanoate + CoA => 13-cis-retinol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005274", "l": "allantoin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805640", "l": "AKT phosphorylates KAT6A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102356", "l": "isoitalicene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + (+)-isoitalicene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11703", "l": "H(+) + NADPH + O2 + progesterone <=> H2O + NADP(+) + testosterone acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761344", "l": "USP18 binds IKBKG within IKK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471322", "l": "Beta-defensins are secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043776", "l": "cobalt-precorrin-6B C5-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052723", "l": "inositol hexakisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688294", "l": "SIRT5 deacetylates Cytochrome C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202248", "l": "Phosphorylation of PLC-gamma1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201630", "l": "Caspase-mediated cleavage of Acinus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14922", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose => 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34744", "l": "15-methylhexadecasphinganine 1-phosphate => 13-methyltetradecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60921", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 => a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69554", "l": "(S)-serinol phosphate + 2-oxoglutarate => dihydroxyacetone phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944229", "l": "Association of procollagen type IX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001647", "l": "G protein-coupled cytokinin receptor activity", "d": ["Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24837", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76262", "l": "H(+)(in) + taurine(in) <=> H(+)(out) + taurine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51676", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23456", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64405", "l": "carnosine(out) + H(+)(out) => carnosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62306", "l": "(+)-premalbrancheamide => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047153", "l": "deoxycytidylate 5-hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470009", "l": "Phosphorylation of STATs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50391", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202111", "l": "AKT1 phosphorylates eNOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2464822", "l": "RDH12 reduces atRAL to atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64657", "l": "(E)-sinapaldehyde + CoA + NADP(+) => (E)-sinapoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65550", "l": "alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base => a ganglioside Fuc-GM1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16178", "l": "H2O + NAD(+) + retinal => 2 H(+) + NADH + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59809", "l": "L-tyrosine => D-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20285", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.4.1.211", "l": "\"1,3-beta-galactosyl-N-acetylhexosamine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003692", "l": "left-handed Z-DNA binding", "d": ["Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33771", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211219", "l": "Translocation of caspase-3 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69914", "l": "adenosine(out) + 2 Na(+)(out) <=> adenosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032397", "l": "activating MHC class I receptor activity", "d": ["Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042301", "l": "phosphate ion binding", "d": ["Binding to a phosphate ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37808", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129353", "l": "Tropoelastin associates with microfibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72011", "l": "glutathione(in) + urate(out) = glutathione(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11921", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.63", "l": "\"meprin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30993", "l": "24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867344", "l": "OMA1 hydrolyses OPA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28418", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33427", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine = bacillithiol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30737", "l": "myo-inositol + phosphate => 1D-myo-inositol 4-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990175", "l": "EH domain binding", "d": ["Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37139", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36639", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine = 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.294", "l": "\"3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17315", "l": "AMP + diphosphate + H(+) + L-histidyl-tRNA(His) => ATP + L-histidine + tRNA(His)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58416", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43324", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65614", "l": "a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353014", "l": "2-phosphoglycerate <=> 3-phosphoglycerate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10634", "l": "D-mannuronate + H(+) + NADH => D-mannonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72978", "l": "2 ATP + 2 indole-3-pyruvate <=> 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43612", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA = 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707683", "l": "PGRMC2 binds Hemes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51119", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237129", "l": "Acireductone is created (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213195", "l": "Formation of anchoring fibrils (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11775", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14726", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375140", "l": "CDO binds promyogenic cadherins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72426", "l": "(E)-4-coumaroyl-AMP + CoA <=> (E)-4-coumaroyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.5", "l": "\"type III site-specific deoxyribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019149", "l": "3-chloro-D-alanine dehydrochlorinase activity", "d": ["Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30219", "l": "dimethyl sulfoxide + H2O + NAD(+) = dimethyl sulfone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.8.1.17", "l": "\"dimethylsulfone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44824", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33754", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818682", "l": "MEN1 binds MLL2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68337", "l": "(R)-4'-phosphopantetheine sulfonate + H2O => (R)-pantetheine sulfonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67443", "l": "H2O + N(alpha)-acetyl-L-methionine <=> acetate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869542", "l": "TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047066", "l": "phospholipid-hydroperoxide glutathione peroxidase activity", "d": ["Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017159", "l": "pantetheine hydrolase activity", "d": ["Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017988", "l": "CRH gene expression is repressed by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39341", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879459", "l": "F-actin capping protein is a heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873923", "l": "STARD10 binds LPCAT1 and PC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76949", "l": "3-methylbutan-2-one + H(+) + NADPH + NH4(+) => 3-methyl-2-aminobutane + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54187", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O <=> a carboxylate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69951", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210444", "l": "L-Glutamate loading of synaptic vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33359", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75735", "l": "10-oxo-(12Z)-octadecenoate = 10-oxo-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32834", "l": "an R-cob(III)alamin(in) <=> an R-cob(III)alamin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934446", "l": "Activated PKC phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852331", "l": "GTSE1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62025", "l": "campesteryl 3-beta-D-glucoside + H2O => campesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691174", "l": "RAC1 binds effectors at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19456", "l": "2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042314", "l": "bacteriochlorophyll binding", "d": ["Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827862", "l": "SOX17 and TFAP2C bind the CBFA2T2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20920", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 = 3,5-dichlorocatechol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.20", "l": "\"2,4-dichlorophenol 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35599", "l": "NADP(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634445", "l": "MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74489", "l": "(-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.76", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40873", "l": "(2E,9Z)-octadecadienoyl-CoA + FADH2 => (9Z)-octadecenoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12505", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11440", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31969", "l": "ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709454", "l": "EPOR binds EPOR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34396", "l": "L-phenylalanine => L-beta-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67878", "l": "3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15044", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O <=> inulobiose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29857", "l": "D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61438", "l": "AMP + H(+) + phosphate => ADP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995330", "l": "COX10 transforms heme to heme O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173723", "l": "C8 binds C5b:C6:C7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41656", "l": "dihydrosanguinarine + NADP(+) = NADPH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70353", "l": "beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose => beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20625", "l": "2 Fe(III)-[cytochrome c3] + H2 = 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.12.2.1", "l": "\"cytochrome-c3 hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19102", "l": "2-butyne-1,4-diol + NAD(+) => 4-hydroxy-2-butynal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30941", "l": "ADP + dITP => ATP + dIDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635846", "l": "GLI proteins bind GLI1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30734", "l": "butanoyl-CoA + FAD + H(+) <=> (2E)-butenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69797", "l": "D-aspartate + H(+) + tRNA(Asp) => D-aspartyl-tRNA(Asp) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44948", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28059", "l": "L-lyxopyranose => L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38787", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507868", "l": "Aquaporins passively transport water into cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48850", "l": "13-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46956", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.1.108", "l": "\"caffeoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41899", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692408", "l": "NPR2 binds NPPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75877", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59838", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15308", "l": "betaine aldehyde + H2O + NAD(+) <=> glycine betaine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687097", "l": "p-S857 NCOA3 binds ETV4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44447", "l": "a 1,2-diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24143", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333051", "l": "RPA1 binds HSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875591", "l": "DOCK7 activates RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62380", "l": "carbaryl + H(+) + H2O = 1-naphthol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.70", "l": "\"sortase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41326", "l": "(12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate => (5Z,8Z,11Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59741", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14983", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => NADP(+) + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36413", "l": "calciol => 7-dehydrocholesterol + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9716913", "l": "ESR1 binds ESR1 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19476", "l": "4-hydroxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36090", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25681", "l": "ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56195", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14757", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18590", "l": "[glutamine synthetase]-L-tyrosine + ATP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56820", "l": "AH2 + cyclooctat-9-en-7-ol + O2 = A + cyclooctat-9-ene-5,7-diol + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.61", "l": "\"cyclooctat-9-en-7-ol 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66843", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17617", "l": "leukotriene C4 = glutathione + leukotriene A4", "d": [], "t": []}, {"i": "EC:4.4.1.20", "l": "\"leukotriene-C4 synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375160", "l": "NCAM1 binds to ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70273", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942302", "l": "MMP13 cleaves OPTC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874685", "l": "CBL binds MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047139", "l": "glutathione-homocystine transhydrogenase activity", "d": ["Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444171", "l": "Receptor FFAR2 binds carboxylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444516", "l": "Formation of MSH2:MSH6 Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73151", "l": "CoA(out) + FMN(in) = CoA(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32211", "l": "(Z)-5-oxohex-2-enedioate = (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080074", "l": "spermidine:caffeoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15148", "l": "D-maltose <=> alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68023", "l": "(2E)-geranyl phosphate + H2O <=> (2E)-geraniol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42243", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67546", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine => (9Z)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20073", "l": "D-allothreonine = acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21624", "l": "FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17352", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10321", "l": "trans-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645481", "l": "TIFA oligomerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42442", "l": "H(+) + iminosuccinate + NADH => L-aspartate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202714", "l": "CD58 binds CD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445448", "l": "HHIP binds Hedgehog (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821368", "l": "AKAP8L binds MLL1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837337", "l": "DCAKD phosphorylates DP-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9612219", "l": "ERBB4s80 binds to SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098782", "l": "mechanosensitived potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610723", "l": "GLI proteins bind SUFU (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210292", "l": "Interaction of DAP12 and TREM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176956", "l": "Formation of GINS complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48139", "l": "a ganglioside GM3 + H2O <=> a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791228", "l": "45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37239", "l": "2',3'-cyclophospho-UMP + H2O = H(+) + uridine 2'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57531", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54443", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) <=> a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68897", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH => 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008804", "l": "carbamate kinase activity", "d": ["Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65545", "l": "a ganglioside GM1 + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110360", "l": "Recruitment of POLB to the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61378", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69938", "l": "guanosine(out) + Na(+)(out) <=> guanosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75362", "l": "L-mimosine <=> 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42283", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689000", "l": "AADAC deacetylates PHEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48283", "l": "a ganglioside GM2 + UDP-alpha-D-galactose <=> a ganglioside GM1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55792", "l": "butan-2-one + H(+) + NADH + O2 = 1-hydroxy-2-butanone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684096", "l": "CDK2 phosphorylates RBBP8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018527", "l": "cyclohexylamine oxidase activity", "d": ["Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63061", "l": "5-methylorsellinate + ATP + H(+) + NADPH => 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21232", "l": "L-histidine = NH4(+) + trans-urocanate", "d": [], "t": []}, {"i": "EC:4.3.1.3", "l": "\"histidine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395412", "l": "Phosphorylation of SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39130", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60153", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O => L-glutamate + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622134", "l": "CRABP1 binds atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68960", "l": "DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418553", "l": "cAMP degradation by Phosphodiesterases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75513", "l": "CoA + H(+) + N-acetyl-S-benzyl-L-cysteine => acetyl-CoA + S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014449", "l": "RHOG binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71665", "l": "a menaquinol + fumarate + 2 H(+)(in) => a menaquinone + 2 H(+)(out) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60973", "l": "hexan-1-ol + NAD(+) => H(+) + hexanal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9837337", "l": "DCAKD phosphorylates DP-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173680", "l": "Activation of C5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38923", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH = a ubiquinol + Na(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72684", "l": "cholate(out) => cholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29871", "l": "ATP + H2O + thiosulfate(out) = ADP + H(+) + phosphate + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43131", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004739", "l": "pyruvate dehydrogenase (acetyl-transferring) activity", "d": ["Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24776", "l": "H2O + pheophorbide a = C-13(2)-carboxypyropheophorbide a + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102142", "l": "[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate = adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35751", "l": "ATP + kanosamine = ADP + D-kanosamine 6-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.179", "l": "\"kanosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432143", "l": "PECAM-1 binds PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714481", "l": "RAC2 binds effectors at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14348", "l": "H(+) + L-tyrosine <=> CO2 + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76138", "l": "a dicarboxylate(in) + urate(out) <=> a dicarboxylate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15784", "l": "L-tyrosine <=> 3-amino-3-(4-hydroxyphenyl)propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70938", "l": "L-lysine(in) <=> L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49011", "l": "aurachin C + H(+) + NADPH + O2 <=> aurachin C epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10040", "l": "adenosine 3',5'-bisphosphate + H2O = AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031458", "l": "ABC-type betaine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37554", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate <=> 2-oxoglutarate + D-kanosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69678", "l": "eriodictyol-7-O-beta-D-glucoside + H2O <=> (S)-eriodictyol + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052705", "l": "methylhistidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56813", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 => 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061809", "l": "NAD+ nucleotidase, cyclic ADP-ribose generating", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose, in a two steps reaction: first an ADP-ribosyl cyclase reaction, followed by a cyclic ADP-ribose hydrolase reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22966", "l": "CO2 + putrescine => H(+) + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45337", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27929", "l": "UMP(in) <=> UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30728", "l": "dATP + pyruvate => dADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030060", "l": "L-malate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170674", "l": "Dissociation of the Gi alpha:G olf complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54924", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168456", "l": "Growth hormone receptor binds Lyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27914", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24224", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) = 4-methylcatechol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71629", "l": "phosphate(out) + succinate(in) => phosphate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796617", "l": "MIB2 binds CFLAR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48903", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59879", "l": "(indol-3-yl)butanoate + ATP + L-cysteine <=> (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69180", "l": "ADP + thiamine diphosphate = AMP + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56430", "l": "(9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112604", "l": "Phosphorylated STATs are released (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43163", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002428", "l": "Removal of fibrillar collagen N-propeptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58131", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788611", "l": "HYKK phosphorylates 5HLYS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57938", "l": "5-pyridoxate + 2 H(+) + NADH => H2O + isopyridoxal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102603", "l": "12-demethyl-elloramycin C12a O-methyltransferase activity", "d": ["Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine = elloramycin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56627", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40307", "l": "A + decanedioyl-CoA = (2E)-decenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453183", "l": "p-Y348-SYK dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17310", "l": "a phenyl acetate + H2O => a phenol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23727", "l": "H2O + O2 + pyridoxal <=> 4-pyridoxate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26242", "l": "geranylgeranyl diphosphate => diphosphate + elisabethatriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.16", "l": "\"methylthioadenosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913446", "l": "Interleukin-5 is a homodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55269", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (R)-glycerate + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080019", "l": "alcohol-forming very long-chain fatty acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696482", "l": "CTF1 binds LIFR:JAKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46482", "l": "4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66219", "l": "asc-C7-CoA + O2 <=> asc-DeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67194", "l": "ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43368", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26331", "l": "(7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate => (8S)-8-amino-7-oxononanoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805061", "l": "CK2 binds FACT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48531", "l": "a ganglioside GP1c (d18:1(4E)) + H2O <=> a ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111912", "l": "CaMK4 phosphorylates CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390329", "l": "Dephosphorylation of AKT by PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692236", "l": "DMRT1 binds the FOXL2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047655", "l": "allyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222237", "l": "SMYD2 methylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30773", "l": "D-ribose + guanine => guanosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0016215", "l": "acyl-CoA desaturase activity", "d": ["Catalysis of the reaction: AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O."], "t": []}, {"i": "RHEA:25416", "l": "AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46254", "l": "a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67177", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite => H(+) + methanol + O13(4)-desmethyl pFDCC", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9639286", "l": "RRAGC,D exchanges GTP for GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44949", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654167", "l": "Activated FGFR1 binds PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018532", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity", "d": ["Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4647594", "l": "SAHF formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193702", "l": "Part of the ICD migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851058", "l": "AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12845", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": [], "t": []}, {"i": "EC:3.4.15.6", "l": "\"cyanophycinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047904", "l": "fructose 5-dehydrogenase activity", "d": ["Catalysis of the reaction: a ubiquinone + keto-D-fructose = 5-dehydro-D-fructose + a ubiquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28314", "l": "baicalein + UDP-alpha-D-glucuronate = baicalin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16882", "l": "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562541", "l": "TLR4-induced ripoptosome assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14212", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015624", "l": "ABC-type ferric-enterobactin transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43157", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664850", "l": "ATM binds PEX5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16411", "l": "H(+) + NADPH + vomilenine => 1,2-dihydrovomilenine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38895", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67081", "l": "a very long-chain fatty acid(in) + ATP + H2O => a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40661", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65316", "l": "2-oxoglutarate + chrodrimanin H + O2 = chrodrimanin E + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16280", "l": "H2O + indole-3-acetaldehyde + O2 <=> (indol-3-yl)acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45499", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23378", "l": "3-dehydro-D-erythronate + H(+) + NADH => L-threonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110215", "l": "Cleavage of uracil by UNG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195275", "l": "Phosphorylation of APC component of the destruction complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70844", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) => L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57381", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029460", "l": "PAK1 phosphorylates LIMK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54895", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937613", "l": "CRHBP binds CRH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51744", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25625", "l": "H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.22", "l": "\"diamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48822", "l": "13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255343", "l": "RAB8A,10,13,14 exchange GDP for GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76061", "l": "H(+) + N-methylheliamine + S-adenosyl-L-homocysteine => heliamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25542", "l": "diphosphate + ent-pimara-8(14),15-diene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047605", "l": "acetolactate decarboxylase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19203", "l": "ADP + dGMP + H(+) => 2'-deoxyguanosine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35719", "l": "(3S)-versiconol acetate + H2O = (S)-versiconol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11233", "l": "3'-phosphoadenylyl sulfate + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0098808", "l": "mRNA cap binding", "d": ["Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41939", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052809", "l": "acharan sulfate lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003786", "l": "actin lateral binding", "d": ["Binding to an actin filament along its length."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297444", "l": "Binding of cAMP to HCN channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32998", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.24", "l": "\"hydroxyacid-oxoacid transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29391", "l": "GTP + H2O = diphosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65385", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32746", "l": "L-homocysteine + O-acetyl-L-serine <=> acetate + H(+) + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57620", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0009009", "l": "site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451310", "l": "Activation of Edited Kainate receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58161", "l": "ent-copalyl diphosphate => diphosphate + dolabradiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9818574", "l": "TASP1 cleaves KMT2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48483", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008200", "l": "NFE2 binds the beta globin locus control region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37376", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55525", "l": "H(+) + H2O + L-dopa + O2 => 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672957", "l": "PP2A dephosphorylates KSR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1169192", "l": "PTP1B dephosphorylates GHR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371554", "l": "HSF1 acetylation at Lys80 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18207", "l": "11alpha-hydroxyprogesterone + A + H2O => AH2 + O2 + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14047", "l": "3-(hydrohydroxyphosphoryl)pyruvate + CO2 => 1-carboxyvinyl carboxyphosphonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50912", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol = 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.46", "l": "\"teichoic acid ribitol-phosphate primase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73806", "l": "AIR + CO2 => CAIR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73154", "l": "CoA(out) + FMN(in) <=> CoA(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54217", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373342", "l": "CX3CR1 binds CX3CL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43064", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate = holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": [], "t": []}, {"i": "EC:2.3.1.238", "l": "\"monacolin J acid methylbutanoate transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72269", "l": "chloride(in) + formate(out) => chloride(out) + formate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213466", "l": "RIPK3 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38115", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050117", "l": "N-acetyl-beta-alanine deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-alanine + H2O = beta-alanine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3244643", "l": "STING binds cyclic GMP-AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698033", "l": "p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10388", "l": "GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65575", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204798", "l": "Interaction of Tie2 and p85 of PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46450", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr) => 2 L-tyrosyl-tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75042", "l": "acetyl-CoA(in) <=> acetyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669240", "l": "FLNA binds PAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67670", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483089", "l": "PE is converted to PS by PTDSS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38404", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428918", "l": "Dissociation of the TP:G13 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68253", "l": "L-tryptophan(in) + Na(+)(in) => L-tryptophan(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139905", "l": "Translocation of activated BAD protein to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031518", "l": "NR1H2,3 binds the APOC1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61413", "l": "ATP + N-(D-erythrulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56281", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] => AMP + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141423", "l": "Binding of the MCC complex to the APC/C complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10279", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033196", "l": "tryparedoxin peroxidase activity", "d": ["Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3341294", "l": "Superoxide reduces cytochrome c (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54922", "l": "13-cis-retinal + H(+) + NADPH => 13-cis-retinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821931", "l": "BOD1L1 binds SET1A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67346", "l": "CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside) => kaempferol 7-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141409", "l": "Mad1 binds kinetochore (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24320", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696960", "l": "USP49 deubiquitinates H2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37380", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446221", "l": "Mannose-1-phosphate converted to GDP-Mannose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047684", "l": "arylamine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74261", "l": "H(+) + L-homoserine + tRNA(Lys) => H2O + L-homoseryl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000227", "l": "oxaloacetate secondary active transmembrane transporter activity", "d": ["Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72308", "l": "L-glutamate(in) + taurocholate(out) => L-glutamate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0046790", "l": "virion binding", "d": ["Binding to a virion, either by binding to components of the capsid or the viral envelope."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.n1", "l": "\"elongation factor 4\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30999", "l": "(S)-2,3-epoxysqualene = cucurbitadienol", "d": [], "t": []}, {"i": "EC:5.4.99.33", "l": "\"cucurbitadienol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58455", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55524", "l": "H(+) + H2O + L-dopa + O2 = 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:4.1.1.107", "l": "\"3,4-dihydroxyphenylacetaldehyde synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798374", "l": "DYRK2 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73609", "l": "CTP(in) + dCTP(out) => CTP(out) + dCTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63103", "l": "H(+) + ilicicolin C + NADPH + O2 <=> ascochlorin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299482", "l": "TIMM23 SORT inserts proteins into inner membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58218", "l": "AH2 + serpentine => A + dihydroserpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865605", "l": "BRWD1 binds SMARCA4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53299", "l": "(2E)-decenoyl-CoA + NADP(+) <=> (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60354", "l": "CO + H(+) + N-octanoylanthranilate => 2-heptyl-3-hydroxy-4(1H)-quinolone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53497", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36007", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67817", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O => a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64129", "l": "H2O + N-octadecanoyl-L-phenylalanine => L-phenylalanine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004594", "l": "pantothenate kinase activity", "d": ["Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102789", "l": "UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40783", "l": "docosanoyl-CoA + H2O = CoA + docosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28838", "l": "citrate(out) + succinate(in) <=> citrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57341", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22939", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate <=> acetate + D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48962", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O => [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696183", "l": "AOC3 deaminates BZAM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10815", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + N-succinyl-L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67804", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 = CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008035", "l": "high-density lipoprotein particle binding", "d": ["Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4167511", "l": "HLCS biotinylates ACACB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44646", "l": "a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59064", "l": "demethylluteothin + S-adenosyl-L-methionine = luteothin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70882", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) <=> L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21225", "l": "CDP-choline + sphing-4-enine => CMP + H(+) + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050646", "l": "5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0004806", "l": "triglyceride lipase activity", "d": ["Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705926", "l": "AR binds AR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612639", "l": "NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57614", "l": "9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+) => 20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656269", "l": "Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950766", "l": "IL27RA dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33540", "l": "ergosteryl ester + H2O => a carboxylate + ergosterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16711", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76224", "l": "3',5'-cyclic AMP(in) => 3',5'-cyclic AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72697", "l": "Start codon recognition (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114352", "l": "Sequestration of tBID by BCL-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72072", "l": "L-histidyl-[protein] + NAD(+) => H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0097506", "l": "deaminated base DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated bases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222128", "l": "NOC2L binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030351", "l": "inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70397", "l": "CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine => 3-oxosphinganine + docosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23345", "l": "a purine D-ribonucleoside + H2O => a purine nucleobase + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24111", "l": "H2O + N-methyl-2-oxoglutaramate <=> 2-oxoglutarate + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170159", "l": "Translocation of Cdc25 to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28958", "l": "aldehydo-D-glucuronate(in) + H(+)(in) <=> aldehydo-D-glucuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419490", "l": "Binding of ATP to P2X receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11744", "l": "H2O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate", "d": [], "t": []}, {"i": "EC:3.6.1.28", "l": "\"thiamine-triphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65959", "l": "ATP + estrone 3-sulfate(out) + H2O <=> ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30121", "l": "dodecanoate + H(+) + holo-[ACP] => dodecanoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671873", "l": "Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60321", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55047", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O <=> (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11250", "l": "(R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66795", "l": "N-methyl-D-dopa + O2 <=> (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334179", "l": "DNMT3A:DNMT3L binds chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33647", "l": "(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42401", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + lactose 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043883", "l": "malolactic enzyme activity", "d": ["Catalysis of the reaction: malate + H+ = L-lactate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72691", "l": "Formation of the 43S pre-initiation complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42812", "l": "cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76540", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine => an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418850", "l": "Activation of Cdc42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.088320895280148", "identifiers": [{"i": "GO:0016814", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2."], "t": []}, {"i": "EC:3.5.4.-", "l": "\"In cyclic amidines\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36818", "l": "dTDP-alpha-D-fucose <=> dTDP-alpha-D-fucofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15282", "l": "lathosterol => 5alpha-cholest-8-en-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73629", "l": "CTP(in) + GMP(out) => CTP(out) + GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54158", "l": "[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-445714", "l": "Aquaporin-3 passively transports water out of cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51517", "l": "(R)-reticuline + S-adenosyl-L-methionine => (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43082", "l": "2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197958", "l": "FPGS-2 transforms THF to THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035403", "l": "histone H3T6 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62171", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72035", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) = ATP(in) + 2 H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694409", "l": "Nucleotide exchange on RAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59002", "l": "H(+) + H2O2 + propanoate => H2O + O2 + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65786", "l": "3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140806", "l": "SERPINC1 binds SERPINC1 activators (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48732", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": [], "t": []}, {"i": "EC:3.13.1.6", "l": "\"[CysO sulfur-carrier protein]-S-L-cysteine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44227", "l": "16-hydroxyhexadecanoate + ATP + CoA <=> 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683774", "l": "p-T68-CHEK2 dimerizes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35601", "l": "3-hydroxypropanal + H(+) + NADPH => NADP(+) + propane-1,3-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76883", "l": "3-aminobutan-1-ol + H2O + NAD(+) = 4-hydroxybutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41343", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20505", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid", "d": [], "t": []}, {"i": "EC:4.3.2.9", "l": "\"gamma-glutamylcyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26083", "l": "(Z)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35556", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005044", "l": "scavenger receptor activity", "d": ["Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050107", "l": "monoterpenol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938913", "l": "RUNX1 binds ELF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418904", "l": "A1 and A3 receptors bind adenosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75820", "l": "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004664", "l": "prephenate dehydratase activity", "d": ["Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000310", "l": "AURKA phosphorylates PLK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21597", "l": "L-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47223", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46716", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17483", "l": "2 cob(II)alamin + NADH => 2 cob(I)alamin + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.203", "l": "\"tRNA (cytosine(34)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55956", "l": "(9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35464", "l": "lathosterol + NAD(+) => 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25529", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451839", "l": "DCO binds to FT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097161", "l": "DH domain binding", "d": ["Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848339", "l": "PNPLA5 hydrolyzes TAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77127", "l": "1D-myo-inositol 1,2,3-trisphosphate + H2O = 1D-myo-inositol 2,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44000", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 = 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950389", "l": "Expression of Stress-70 protein, mitochondrial (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762333", "l": "ANGPTL4 binds to CDH11v (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26492", "l": "a ketone + H(+) + H2O2 + nitrite => a secondary nitroalkane + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57097", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72850", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) <=> adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692437", "l": "ANG binds F-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39843", "l": "a 1,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70239", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69421", "l": "H2O2 + iodide => H2O + hypoiodite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934465", "l": "SHC1 binds PTPN12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709317", "l": "CO binds to free ferrohemoglobin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38266", "l": "(2R,3S)-beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65050", "l": "4-acetoxybenzaldehyde + H(+) + NADH => 4-acetoxybenzyl alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696491", "l": "CNTF binds CNTFR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615829", "l": "IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64447", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47475", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH <=> (3E)-tetradecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18221", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.59", "l": "\"alkylacetylglycerophosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68693", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) => 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624668", "l": "CEBPA binds CDKN1A (p21) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.024411547311772", "identifiers": [{"i": "GO:0098631", "l": "cell adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42276", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11323", "l": "UDP-beta-L-arabinopyranose <=> UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029992", "l": "Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033912", "l": "2,6-beta-fructan 6-levanbiohydrolase activity", "d": ["Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46845", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004064", "l": "arylesterase activity", "d": ["Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35914", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29136", "l": "a menaquinol + 2 H(+)(in) + nitrate => a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48560", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64974", "l": "dUMP + H(+) + phosphate => dUDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40920", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55553", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44912", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168459", "l": "Lyn activates ERK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21606", "l": "2-phenylacetaldehyde => styrene oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939829", "l": "ITGBL1 gene expression is stimulated by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615249", "l": "ARBs bind AGRT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10283", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine <=> caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50457", "l": "prostaglandin H3 => prostaglandin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43521", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 => 2,5-dicarboxyfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73806", "l": "AIR + CO2 => CAIR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110307", "l": "REV1 binds AP-dsDNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798347", "l": "E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18360", "l": "NADP(+) + tropine <=> H(+) + NADPH + tropinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34976", "l": "(R)-pantothenate(in) => (R)-pantothenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11941", "l": "2 H(+) + H2O + L-citrulline => CO2 + L-ornithine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67717", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40126", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265858", "l": "Activation of ATR by interaction with RAD9-TopBP1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34905", "l": "glutathione disulfide + 3 H2O + selenodiglutathione => 4 glutathione + 2 H(+) + selenite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646468", "l": "mTORC1 binds RHEB:GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45779", "l": "(indol-3-yl)acetonitrile + 2 H2O <=> (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21531", "l": "[phosphate](n) + H2O <=> [phosphate](n-1) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65381", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73326", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA <=> cimicifugate D + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202137", "l": "AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45170", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine => 2 (E)-sinapoyl-CoA + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59472", "l": "2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68975", "l": "A + sn-glycerol 3-phosphate <=> AH2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106615", "l": "Removal of siRNA passenger strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15326", "l": "an acyl-CoA + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55074", "l": "CO2 + propanal => 2-oxobutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047172", "l": "shikimate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729725", "l": "SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22503", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA <=> (E)-feruloylacetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021068", "l": "PalmS-ESRs bind CAVs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2272668", "l": "Interaction of DAP12 and KIR2DS5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21002", "l": "1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008226", "l": "tyramine receptor activity", "d": ["Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55397", "l": "(R)-carnitine + H(+) + NADH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.054967706738452", "identifiers": [{"i": "GO:0016651", "l": "oxidoreductase activity, acting on NAD(P)H", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55747", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47669", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) => 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49229", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) => diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42047", "l": "a globoside GalGb4Cer (d18:1(4E)) + GDP-beta-L-fucose <=> a globoside Globo-H (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65214", "l": "(2E)-dodecenoate + CoA + H(+) => (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44410", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665727", "l": "FMNL2 binds CDC42:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004119", "l": "cGMP-inhibited cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19034", "l": "an N-acyl-D-glucosamine => an N-acyl-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52332", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] = 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19577", "l": "luteolin + UDP-alpha-D-glucose = H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34655", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.263", "l": "\"botryococcene C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44746", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O => 4 H(+) + 4 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64540", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}, {"i": "EC:2.7.1.228", "l": "\"mannosyl-inositol-phosphoceramide inositolphosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61357", "l": "ATP + H2O + methotrexate(in) => ADP + H(+) + methotrexate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67825", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O => a lipid X + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051741", "l": "2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983285", "l": "RAD51B binds RAD51C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11025", "l": "ATP + NH4(+) => ADP + 2 H(+) + phosphoramidate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41634", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015648", "l": "lipid-linked peptidoglycan transporter activity", "d": ["Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65008", "l": "ATP + decanoate + H(+) = decanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48778", "l": "19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019108", "l": "aryl-aldehyde dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25493", "l": "(2E)-geranyl diphosphate => (-)-beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34724", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O => 15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052855", "l": "ADP-dependent NAD(P)H-hydrate dehydratase activity", "d": ["Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H+ + NADH + phosphate."], "t": []}, {"i": "EC:4.2.1.136", "l": "\"ADP-dependent NAD(P)H-hydrate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664406", "l": "IgG:Lma antigens binds FCGR3A:CD3 dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68951", "l": "esculetin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53055", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38659", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74189", "l": "H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether => S-adenosyl-L-methionine + taxifolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38097", "l": "alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine => gamma-tocotrienol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.35", "l": "\"tissue kallikrein\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60700", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39472", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015111", "l": "Factor Xa inhibitors binds Xa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011748", "l": "IL9R binds JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10028", "l": "D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69055", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 <=> 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62793", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B => 2 H2O + NADP(+) + nigerone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63220", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine = 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169402", "l": "ISGylation of E2 conjugating enzymes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15372", "l": "2,3-dihydroxybenzoate + O2 <=> 2-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47578", "l": "a ganglioside GD1c (d18:1(4E)) + CMP + H(+) => a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49941", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17214", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876484", "l": "NPC2 transfers CHOL to NPC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46894", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate => 2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19270", "l": "2-furoate + ATP + CoA => 2-furoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15844", "l": "D-glucose 6-phosphate + NADP(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247837", "l": "WNT ligands traffic to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62167", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O <=> D-glucosamine + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004110", "l": "corticosteroid side-chain-isomerase activity", "d": ["Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672948", "l": "MARK3 phosphorylates KSR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187828", "l": "Translocation of p21 to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419426", "l": "Cannabinoid receptors can bind cannabinoids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64388", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate = 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005469", "l": "succinate:fumarate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37545", "l": "2-amino-5-chloromuconate 6-semialdehyde => 2-amino-5-chlorophenol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47616", "l": "ethionamide + H(+) + NADPH + O2 = ethionamide S-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027600", "l": "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043956", "l": "3-hydroxypropionyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: 3-hydroxypropionyl-CoA = acryloyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51928", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) = (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.51", "l": "\"N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805740", "l": "SETD8 methylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980078", "l": "NOTCH1 stimulates HES5 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26211", "l": "acetaldehyde + glycine => L-allo-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58247", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] <=> ADP-D-ribose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41984", "l": "NAD(+) + propan-2-ol = acetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030280", "l": "structural constituent of skin epidermis", "d": ["The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007882", "l": "IL1F10 is cleaved (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75971", "l": "NADP(+) + neomorphine = H(+) + NADPH + neomorphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12327", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> L-asparagine + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28964", "l": "H(+)(out) + L-proline(out) => H(+)(in) + L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61463", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810076", "l": "DDO oxidizes D-Asp to OA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58530", "l": "(16R)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64548", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] = (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36177", "l": "1-O-alkyl-sn-glycero-3-phosphate + NADP(+) => 1-O-alkylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33212", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) => 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56173", "l": "FMN + O2 => 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69363", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033429", "l": "CGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14481", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.87", "l": "\"2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428123", "l": "KDSR reduces 3-ketosphingoid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17872", "l": "5,6,7,8-tetrahydropteridine + NAD(+) <=> 6,7-dihydropteridine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35438", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose <=> cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43623", "l": "L-serine + NADP(+) <=> aminoacetaldehyde + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.3", "l": "\"ribonuclease III\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20066", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39510", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047453", "l": "ATP-dependent NAD(P)H-hydrate dehydratase activity", "d": ["Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H+ + NADH + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13986", "l": "ATP + L-homoserine => ADP + H(+) + O-phospho-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141423", "l": "Binding of the MCC complex to the APC/C complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0009883", "l": "red or far-red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12812", "l": "4 catechol + 3 O2 <=> 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46433", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580269", "l": "Defective CYP11A1 does not cleave 20a,22b-DHCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74719", "l": "myricetin + S-adenosyl-L-methionine = 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982807", "l": "JAK2 phosphorylation of GHR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004522", "l": "ribonuclease A activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382058", "l": "Nck binds to the active PDGF receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166817", "l": "Cleavage of C3 by C3 convertases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16942", "l": "N-acetylindoxyl + O2 => H2O + N-acetylisatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25230", "l": "L-arabinitol + NADP(+) => H(+) + L-arabinose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10219", "l": "[DNA-directed RNA polymerase] + ATP <=> ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.3", "l": "\"phosphoserine phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033982", "l": "3-dehydro-L-gulonate-6-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32074", "l": "geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31299", "l": "H2O + NAD(+) + perillyl aldehyde = 2 H(+) + NADH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807106", "l": "PTEN undergoes monoubiquitination (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41165", "l": "1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-amino-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685608", "l": "CLEC2B binds KLRF1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.56", "l": "\"lytic cellulose monooxygenase (C4-dehydrogenating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306876", "l": "NLRP3 activation by small molecules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44165", "l": "ATP + H2O => adenine + D-ribose 5-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25025", "l": "H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine", "d": [], "t": []}, {"i": "EC:3.5.4.31", "l": "\"S-methyl-5'-thioadenosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37876", "l": "aklanonate + S-adenosyl-L-methionine => methyl aklanonate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640167", "l": "RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33235", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.81", "l": "\"magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981657", "l": "IL34 dimer binds PTPRZ1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804229", "l": "JMY, TTC5 and EP300 bind (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22310", "l": "D-xylose + H2O2 => O2 + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53176", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981093", "l": "IL12 bound to IL12R internalises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061768", "l": "magnesium:sodium antiporter activity", "d": ["Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729232", "l": "SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388503", "l": "Oxytocin receptor bind oxytocin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17560", "l": "anthranilate + malonyl-CoA <=> CoA + N-malonylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-706479", "l": "TAK1 is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110307", "l": "REV1 binds AP-dsDNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799350", "l": "Exocytosis of specific granule membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013435", "l": "RHOD auto-activates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.23", "l": "\"rhamnogalacturonan endolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13487", "l": "3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate => 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29201", "l": "menaquinol-8 + orotate => (S)-dihydroorotate + menaquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449818", "l": "IL13 binds IL13RA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41820", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198983", "l": "NKG2D homodimer interacting with ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451895", "l": "IL2RG binds JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56358", "l": "2,4-dibromophenol + CO2 + 2 H2O + NADP(+) => 3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41190", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008824", "l": "cyanate hydratase activity", "d": ["Catalysis of the reaction: cyanate + H2O = carbamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202713", "l": "CD84 homodimerises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15170", "l": "H2O + N-succinyl-L-glutamate => L-glutamate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37500", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44562", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-heptaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51405", "l": "H2O + L-arginine + O2 => 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30809", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH => L-pipecolate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655323", "l": "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878702", "l": "p-BMAL1:p-CLOCK,NPAS2 binds KLF15 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36071", "l": "6-tuliposide A = D-glucose + tulipalin A", "d": [], "t": []}, {"i": "EC:4.2.99.22", "l": "\"tuliposide A-converting enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015498", "l": "pantothenate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16516", "l": "(S)-lactate + O2 <=> acetate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.191", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795667", "l": "MDM2 translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.23", "l": "\"dUTP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905575", "l": "ganglioside GM3 binding", "d": ["Binding to ganglioside GM3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38643", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55268", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate = (R)-glycerate + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.352", "l": "\"glucosylglycerate phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59227", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + hydropyrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140410", "l": "monoatomic cation:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034546", "l": "2,4-dichloroaniline reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25655", "l": "aminoacetone + CO2 => (2S)-2-amino-3-oxobutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65016", "l": "chlorothalonil + H2O = 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57480", "l": "2-hydroxydodecanoate + H2O2 = 2,3-dihydroxydodecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10144", "l": "a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.6", "l": "\"3'-nucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749253", "l": "Formation of MCM2-7 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389354", "l": "Activation of Vav1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45387", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73084", "l": "chrysoeriol + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + velutin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982810", "l": "JAK2 phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29950", "l": "H(+)(in) + L-rhamnopyranose(in) <=> H(+)(out) + L-rhamnopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23133", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] => 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0051400", "l": "BH domain binding", "d": ["Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62876", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate = A + semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617484", "l": "EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0010326", "l": "methionine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44552", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32111", "l": "S-adenosyl-L-methionine + trans-resveratrol = 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416698", "l": "SEMA5A binds to PLXNB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610732", "l": "GSK3 phosphorylates p-GLI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60227", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20986", "l": "an N-acylsphing-4-enine 1-phosphate + choline + H(+) => a sphingomyelin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781814", "l": "USP19 deubiquitinates RNF123 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77369", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n+1) + CMP + H(+) => [N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25759", "l": "ent-copalyl diphosphate = diphosphate + ent-isokaurene", "d": [], "t": []}, {"i": "EC:4.2.3.103", "l": "\"ent-isokaurene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888577", "l": "Synthesis of GABA by GAD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29728", "l": "ethane-1-sulfonate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65185", "l": "2-oxoglutarate + O2 + preaustinoid A1 => berkeleyone B + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34070", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate <=> diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25456", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-humulene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55286", "l": "all-trans-retinyl tetradecanoate + CoA => all-trans-retinol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51138", "l": "(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11031", "l": "ATP + D-mannose <=> ADP + D-mannose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45309", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide => 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43820", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30504", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde => acetate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37425", "l": "aclacinomycin A + H2O2 => aclacinomycin N + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624272", "l": "MMPs cleave HB-EGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56561", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664867", "l": "NBR1 binds MAP1LC3B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22347", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA <=> (R)-rosmarinate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65778", "l": "3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49806", "l": "FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050816", "l": "phosphothreonine residue binding", "d": ["Binding to a phosphorylated threonine residue within a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004556", "l": "alpha-amylase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15146", "l": "D-maltose => alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045301", "l": "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity", "d": ["Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30972", "l": "7,7',9,9'-tetra-cis-lycopene => all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74224", "l": "H2O + L-seryl-tRNA(Ala) => L-serine + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417898", "l": "P2Y4 receptor can bind to UTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65241", "l": "(11Z)-octadecenoyl-CoA + H2O => (11Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61320", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72834", "l": "3',3'-cGAMP + H2O <=> G[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28778", "l": "dinoflagellate luciferin + O2 <=> H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.12", "l": "\"lachrymatory-factor synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140787", "l": "phosphate ion uniporter activity", "d": ["Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42730", "l": "2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2791) in 21S rRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381668", "l": "cAMP activates EPAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046990", "l": "N-hydroxyarylamine O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68890", "l": "2-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 2-methoxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964773", "l": "OXGR1 binds 2OG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18534", "l": "5-hydroxy-L-tryptophan + H(+) => CO2 + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59694", "l": "D-cellotrionate + H(+) => D-cellotriono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38009", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19290", "l": "H2O + sucrose 6(F)-phosphate => phosphate + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52085", "l": "13-octadecanoyloxy-octadecanoate + H2O => 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050393", "l": "vinylacetyl-CoA delta-isomerase activity", "d": ["Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0032549", "l": "ribonucleoside binding", "d": ["Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140855", "l": "histone H3S57 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 57) + ATP = histone H3-phosphoserine (position 57) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 57 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38028", "l": "(E)-caffeate + hydrocaffeoyl-CoA => (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25420", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O = 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}, {"i": "EC:1.3.99.n1", "l": "\"3-hydroxybenzoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625426", "l": "Retrograde IFT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111915", "l": "CAMK4 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14653", "l": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.17", "l": "\"3',5'-cyclic-nucleotide phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34025", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102194", "l": "protein-fructosamine 3-kinase activity", "d": ["Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine = ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.160", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22890", "l": "succinyl-CoA => (R)-methylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38941", "l": "diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose => dioscin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.112", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69531", "l": "chorismate + H2O + 2 L-glutamine <=> 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18723", "l": "diphosphate + ent-13-epi-manoyl oxide => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53012", "l": "2,5-dichlorohydroquinone + 2 glutathione = chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.17", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22491", "l": "S-(hydroxymethyl)glutathione <=> formaldehyde + glutathione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60812", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 = CO2 + gibberellin A12 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24341", "l": "(R,R)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44344", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide A + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806974", "l": "MET dimers autophosphorylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944218", "l": "Association of procollagen type VIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938121", "l": "SERPINB13 binds CTSK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52599", "l": "lithocholoyl-CoA + NAD(+) <=> 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864569", "l": "WWOX binds TFAP2C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20157", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] = an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.6", "l": "\"polyvinyl alcohol dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60251", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391935", "l": "DP1 receptor can bind PGD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433542", "l": "Phosphorylation and activation of VAV1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683735", "l": "CHEK2 is recruited to DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50029", "l": "H2O + tetradecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70612", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29952", "l": "H(+)(in) + uridine(in) => H(+)(out) + uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52622", "l": "2,2-dimethylpropanoyl-CoA => 3-methylbutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11575", "l": "FAD + H(+) + H2O + lithocholate <=> chenodeoxycholate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11412", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.6.3", "l": "\"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696356", "l": "OSCAR binds collagen and SP-D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30412", "l": "benzoyl-CoA + benzyl alcohol => benzyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23922", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54645", "l": "trans-4-hydroxy-L-proline => (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40277", "l": "(2E)-hexadecenedioyl-CoA + H2O2 => hexadecanedioyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65062", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34596", "l": "H(+) + isopentadecanoyl-CoA + L-serine => 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080002", "l": "UDP-glucose:4-aminobenzoate acylglucosyltransferase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68615", "l": "Formation of ORC(1-6) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31731", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.12", "l": "\"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75622", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> ectocarpin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34359", "l": "a 1,2-diacylglycerol + H2O = a 2-acylglycerol + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49148", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.324", "l": "\"dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.206", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139952", "l": "Caspase-8 processing in the DISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48928", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21006", "l": "2-dehydropantolactone + AH2 => (R)-pantolactone + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58576", "l": "dihydroprecondylocarpine acetate + NADP(+) = H(+) + NADPH + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46721", "l": "(3R)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17729", "l": "an acyl-CoA + cholesterol = a cholesterol ester + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.46", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021954", "l": "MECP2 binds OPRK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47679", "l": "ATP + N-acetyl-D-galactosamine <=> ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033701", "l": "dTDP-galactose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140786", "l": "glutamine sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16096", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879562", "l": "SLCO2B1 has a narrow substrate specificity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865774", "l": "TTLLs polyglutamylate tubulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297275", "l": "CD9:Izumo Binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37840", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10992", "l": "glycolate + NADP(+) = glyoxylate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.79", "l": "\"glyoxylate reductase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14693", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.153", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0019210", "l": "kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45837", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.3.-", "l": "\"Cyclo-ligases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214878", "l": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69423", "l": "H2O2 + iodide <=> H2O + hypoiodite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70930", "l": "(R)-glycerate(in) + H(+)(in) <=> (R)-glycerate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34234", "l": "5-nitrosalicylate + O2 <=> 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75850", "l": "Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017491", "l": "RHOJ GEFs activate RHOJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51307", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33787", "l": "3'-ketolactose + H2O = 3-keto-beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68914", "l": "DNA polymerase alpha:primase binds at the origin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.1", "l": "\"nitrilase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16907", "l": "a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63071", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 2 CO2 + 3 CoA + triacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22116", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.191", "l": "\"luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042163", "l": "interleukin-12 beta subunit binding", "d": ["Binding to the beta subunit of interleukin-12."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199144", "l": "Nectin 2 binds CD226 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25959", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551648", "l": "SUMOylation of TDG with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44424", "l": "a fatty acyl-CoA + heptadecasphing-4-enine = CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102928", "l": "beta-solanine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76587", "l": "(6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + 2-oxoglutarate + AH2 + H(+) + O2 = (2S)-5,5-dimethylpiperidine-2-carboxylate + A + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047230", "l": "flavonol-3-O-glucoside L-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15659", "l": "3-methylcatechol + CO2 + NADH => 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47285", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430135", "l": "p-SLP-76 binds ADAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39529", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62412", "l": "(E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66618", "l": "Mg(2+)(out) + 2 Na(+)(in) => Mg(2+)(in) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37731", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964773", "l": "OXGR1 binds 2OG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25446", "l": "(1E,4E)-germacrene B + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49999", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22267", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649856", "l": "Oxidative damage to the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40271", "l": "O2 + tetradecanedioyl-CoA = (2E)-tetradecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22998", "l": "2 H2O + L-dehydroascorbate => H2O2 + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37338", "l": "5,6-dihydrothymine + H2O <=> 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052617", "l": "ent-kaur-16-en-19-al oxidase activity", "d": ["Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102875", "l": "1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2219524", "l": "PDPK1 binds PIP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74869", "l": "(E)-caffeoyl-CoA + H(+) + NADPH => (E)-caffeyl aldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49164", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36166", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16975", "l": "2,5-dihydroxypyridine + A + H2O => 2-hydroxypyridine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28312", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9652264", "l": "ERBB2 binds TKIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176956", "l": "Formation of GINS complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23582", "l": "prostaglandin I2 => prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22652", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.69", "l": "\"glucosylglycerol 3-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48082", "l": "ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21701", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10933", "l": "ATP + L-aspartate + L-citrulline => 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53953", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36463", "l": "glycyl-L-glutamate + H2O = glycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41044", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21257", "l": "3-phosphoshikimate + phosphoenolpyruvate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69169", "l": "H2O + NAD(+) + spermine monoaldehyde => 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15776", "l": "ATP + dihydroxyacetone <=> ADP + dihydroxyacetone phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655830", "l": "Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21506", "l": "1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde => acetoin + aldehydo-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53135", "l": "A + a 3-oxo-Delta(4)-steroid <=> a 3-oxo-Delta(1,4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448958", "l": "Nuclear translocation of p38 MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.15", "l": "\"diaminopropionate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786190", "l": "CMBL hydrolyses OM to OLMS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45797", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74147", "l": "(S)-2-benzoylsuccinyl-CoA + CoA = benzoyl-CoA + succinyl-CoA", "d": [], "t": []}, {"i": "EC:2.3.1.310", "l": "\"benzoylsuccinyl-CoA thiolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949580", "l": "F1Fo ATP synthase dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052676", "l": "3-methylbutanol:NAD oxidoreductase activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.348834789597348", "identifiers": [{"i": "GO:0180030", "l": "inositol phosphate kinase activity", "d": ["Catalysis of the reaction: inositol phosphate + ATP = inositol phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23257", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine => adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73634", "l": "CTP(out) + dGTP(in) <=> CTP(in) + dGTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45386", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47853", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102997", "l": "progesterone 5beta- reductase activity", "d": ["Catalysis of the reaction: H+ + progesterone + NADPH = 5beta-pregnane-3,20-dione + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801776", "l": "REG3A binds bacterial phospholipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047717", "l": "imidazoleacetate 4-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + imidazol-4-ylacetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42038", "l": "7-oxolithocholate + H(+) + NADH => chenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12222", "l": "4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-leucine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848776", "l": "PTK6 phosphorylates DOK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28168", "l": "5-nitrosalicylate + NH4(+) => 5-nitroanthranilate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39305", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14847", "l": "(S)-2,3-dihydrodipicolinate + H(+) + 2 H2O => L-aspartate 4-semialdehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.3", "l": "\"ABC-type sulfate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75079", "l": "Formation of AT-AC C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700186", "l": "Autophosphorylation of point mutants of ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693347", "l": "HTR1A binds 5HT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383190", "l": "HCO3- transport through ion channel (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48734", "l": "[CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10659", "l": "guanidinoacetate + S-adenosyl-L-methionine <=> creatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77746", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30579", "l": "H2O + O-phospho-L-threonine = L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19089", "l": "S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74586", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] <=> N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23101", "l": "ATP + dAMP => ADP + dADP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52736", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate = (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727819", "l": "TAK1 phosphorylates MKK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18637", "l": "H2 + NADP(+) = H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53305", "l": "AH2 + 2 ATP + 2 cob(II)alamin => A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710106", "l": "ELANE cleaves GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29846", "l": "ATP + CoA + propanoate <=> ADP + phosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165162", "l": "Phosphorylation of TSC2 by PKB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56996", "l": "aldehydo-D-apiose = apulose", "d": [], "t": []}, {"i": "EC:5.3.1.36", "l": "\"D-apiose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29133", "l": "H2O + menaquinone-8 + nitrite => menaquinol-8 + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56833", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) => 2,3,6-trichlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451033", "l": "(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182988", "l": "Sprouty lures CBL away from EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63501", "l": "H(+) + NADPH + S-nitrosoglutathione => NADP(+) + sulfinamide glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76416", "l": "Benzene is hydroxylated to phenol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391372", "l": "GNRHR binds GNRH1,2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201457", "l": "BMP2 binds to the receptor complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036219", "l": "GTP diphosphatase activity", "d": ["Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217255", "l": "FMO1:FAD N-oxidises TAM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49541", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60793", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 => 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004001", "l": "adenosine kinase activity", "d": ["Catalysis of the reaction: ATP + adenosine = ADP + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34827", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 = H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50405", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] => 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790041", "l": "Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43062", "l": "beta-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37733", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262777", "l": "TRAF6 binds to p-IRAK2   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674558", "l": "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12576", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose = (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.66", "l": "\"procollagen glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034521", "l": "1-naphthoic acid dioxygenase activity", "d": ["Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.60", "l": "\"dactylysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20957", "l": "2-phenylacetate + ATP + CoA => AMP + diphosphate + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842656", "l": "ALK binds ALKAL ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58362", "l": "(5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388830", "l": "PI3K binds ICOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.14", "l": "\"nitric oxide reductase [NAD(P)(+), nitrous oxide-forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16090", "l": "H2O + phosphoethanolamine => ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451403", "l": "Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57831", "l": "dIMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043183", "l": "vascular endothelial growth factor receptor 1 binding", "d": ["Binding to a vascular endothelial growth factor receptor 1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655170", "l": "RCHY1 monoubiquitinates POLH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59629", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine => 4-aminobutanoate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38228", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46255", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60811", "l": "gibberellin A19 + H(+) + O2 <=> CO2 + gibberellin A20 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46861", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008453", "l": "alanine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33518", "l": "2 5,6-dihydroxyindole + O2 <=> 2 H2O + 2 indole-5,6-quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62289", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71980", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56094", "l": "biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n) => bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.207", "l": "\"xyloglucan:xyloglucosyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176956", "l": "Formation of GINS complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810899", "l": "TGM1 and involucrin bind the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031881", "l": "DPAn-3 resolvins translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68852", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1S,6S,7R)-sesquipiperitol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75211", "l": "Cu(+)(out) = Cu(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18375", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31908", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine => (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52074", "l": "(9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55442", "l": "H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46855", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25435", "l": "beta-D-ribopyranose <=> beta-D-ribofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0046403", "l": "polynucleotide 3'-phosphatase activity", "d": ["Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57687", "l": "4-hydroxyestrone + NH4(+) + O2 <=> 2 H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69226", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+) => a (Z)-alkenyl glucosinolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54523", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cycloaraneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102235", "l": "1-penten-3-one reductase activity", "d": ["Catalysis of the reaction: 1-penten-3-one + NADPH + H+ = 1-pentan-3-one + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050114", "l": "myo-inosose-2 dehydratase activity", "d": ["Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69003", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32222", "l": "all-trans-lycopene <=> gamma-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20620", "l": "L-galactono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62630", "l": "an alcohol + H2O + NAD(+) => a hydroperoxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76678", "l": "1-deoxysphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-1-deoxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50792", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199910", "l": "MSK1 activates ATF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41284", "l": "H2O + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098615", "l": "dimethyl selenide methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium."], "t": []}, {"i": "REACT:R-HSA-2408554", "l": "Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050521", "l": "alpha-glucan, water dikinase activity", "d": ["Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141102", "l": "tRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: 5-carboxymethylaminomethyluridine34 in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNA(Leu) + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58186", "l": "(14E,18E)-lycopadiene + 2 diphosphate + NADP(+) => H(+) + NADPH + 2 phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52212", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0050736", "l": "O-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70417", "l": "(3,5-dihydroxyphenyl)acetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54440", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) = a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373748", "l": "SEMA4D interacts with CD72 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102768", "l": "anthocyanidin synthase activity", "d": ["Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12288", "l": "an alpha-L-fucoside + H2O = an alcohol + L-fucose", "d": [], "t": []}, {"i": "EC:3.2.1.51", "l": "\"alpha-L-fucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823816", "l": "OPTN binds CASP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165680", "l": "Formation of active mTORC1 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36929", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25647", "l": "(R)-pulegone + H(+) + NADPH => (2R,5R)-isomenthone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1250280", "l": "ROS oxidize thioredoxin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41150", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65092", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850997", "l": "TRIM27 binds PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851071", "l": "STAT3, DNMT1 and HDAC1 bind PTPN6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614544", "l": "Sulfite is oxidized to sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42165", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034001", "l": "chondroitin-sulfate-ABC exolyase activity", "d": ["Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73734", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate <=> (2S,3R,11S)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707856", "l": "PGRMC2:Hemes dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030735", "l": "carnosine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683478", "l": "CQ, HCQ diffuses from cytosol to endocytic vesicle lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042945", "l": "D-serine transmembrane transporter activity", "d": ["Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72888", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] => ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61943", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose <=> 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46037", "l": "2'-deoxycytidine + UTP => dCMP + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237119", "l": "Acireductone is oxidized to MOB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61361", "l": "ATP + H2O + pheophorbide a(in) => ADP + H(+) + pheophorbide a(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13350", "l": "jasmonate + S-adenosyl-L-methionine => methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45583", "l": "D-galactaro-1,5-lactone <=> D-galactaro-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66888", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33776", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61816", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose = 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77411", "l": "acrolein + hydrogen cyanide = (2S)-2-hydroxybut-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017096", "l": "acetylserotonin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18256", "l": "(S)-malate + NADP(+) <=> CO2 + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60405", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77379", "l": "H(+) + hnu + tetradecanoate = CO2 + tridecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66904", "l": "A + cannabinerolate = AH2 + cannabichromenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44643", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP <=> a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033949", "l": "fructan beta-(2,6)-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64738", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => 4-hydroxynonanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.1", "l": "\"receptor protein-tyrosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700175", "l": "Active ALK phosphorylates SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22830", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) => 1-(5-phospho-beta-D-ribosyl)-ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74468", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O => a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50727", "l": "(E)-4-hydroxyphenylacetaldehyde oxime <=> (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0003975", "l": "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004362", "l": "glutathione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174967", "l": "NAT2 acetylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13146", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate => alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032523", "l": "silicon efflux transmembrane transporter activity", "d": ["Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55606", "l": "a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050318", "l": "tannase activity", "d": ["Catalysis of the reaction: digallate + H2O = 2 gallate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71468", "l": "H2O + substance P => L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73096", "l": "AMP(out) + CoA(in) => AMP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17915", "l": "H(+) + NADH + nitrate => H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687377", "l": "Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61194", "l": "CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13546", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] => (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21452", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}, {"i": "EC:1.14.17.3", "l": "\"peptidylglycine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39336", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19811", "l": "CO2 + glyoxylate + 2 NH4(+) => (S)-ureidoglycolate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14165", "l": "acetyl-CoA + L-aspartate = CoA + H(+) + N-acetyl-L-aspartate", "d": [], "t": []}, {"i": "EC:2.3.1.17", "l": "\"aspartate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71579", "l": "CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350598", "l": "Arginine<=>Agmatine+CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.418", "l": "\"plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47670", "l": "2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63352", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204169", "l": "PDP dephosphorylates p-lipo-PDH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64890", "l": "AMP + diphosphate + tetradecanoyl-[ACP] => ATP + holo-[ACP] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140818", "l": "mRNA 5'-phosphatase activity", "d": ["A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018668", "l": "3-hydroxybenzoate 4-monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609689", "l": "HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28429", "l": "D-allulose 6-phosphate <=> keto-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031516", "l": "far-red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64991", "l": "CoA + H2O <=> (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035612", "l": "AP-2 adaptor complex binding", "d": ["Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0030295", "l": "protein kinase activator activity", "d": ["Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560493", "l": "Expression of Perilipin (PLIN) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25326", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74759", "l": "isorhamnetin + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10132", "l": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.25", "l": "\"benzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005220", "l": "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640167", "l": "RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807826", "l": "LDHAL6B reduces PYR to LACT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32397", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2S,4S)-dihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.45", "l": "\"helper-component proteinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139906", "l": "Activation of BAD by calcineurin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995388", "l": "PP2A dephosphorylates BANF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229283", "l": "LCNs bind lipids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222491", "l": "Lactoferrin scavenges iron ions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25269", "l": "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54323", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803240", "l": "Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18347", "l": "a cis-alkene + CO2 => a cis-3-alkyl-4-alkyloxetan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77444", "l": "a ganglioside GT3 + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GT2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24836", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.23", "l": "\"formate--phosphoribosylaminoimidazolecarboxamide ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59320", "l": "D-cellobiono-1,5-lactone + H2O = 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39383", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32718", "l": "(2R,3S)-3-methylmalate + NAD(+) <=> 2-oxobutanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58611", "l": "2 L-ascorbate + N-decanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050349", "l": "triacetate-lactonase activity", "d": ["Catalysis of the reaction: H2O + triacetate lactone = triacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047482", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity", "d": ["Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015572", "l": "N-acetylglucosamine transmembrane transporter activity", "d": ["Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759158", "l": "SQSTM1 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20222", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate => (6R)-10-formyltetrahydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669240", "l": "FLNA binds PAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64190", "l": "a fatty acid + L-tyrosine => an N-(fatty acyl)-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46755", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41434", "l": "5-hydroxy-3-methyl-L-tyrosine + H2O => 3-methyl-L-tyrosine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77395", "l": "hydrogen cyanide + propanal = (2S)-2-hydroxybutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53339", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102388", "l": "UDP-N,N'-diacetylbacillosamine 2-epimerase activity", "d": ["Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77290", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51556", "l": "(S)-glaucine + S-adenosyl-L-methionine = (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050076", "l": "maleate isomerase activity", "d": ["Catalysis of the reaction: maleate = fumarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798528", "l": "S100A8:S100A9 binds Mn2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37741", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74711", "l": "Phosphorylation of IRS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27728", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 5-dehydro-4-deoxy-D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53720", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.221", "l": "\"N-acetylmuramate 1-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38945", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48395", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928614", "l": "EFNB:GRB4 binds GIT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72909", "l": "D-mannose(in) + Na(+)(in) => D-mannose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27571", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate => ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67295", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036141", "l": "L-phenylalanine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373887", "l": "lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549129", "l": "OCT1 transports organic cations into hepatic cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13345", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:2.5.1.58", "l": "\"protein farnesyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964939", "l": "Phosphorylation of shikimate (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689861", "l": "Recruitment of XPA and release of CAK  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391933", "l": "EP3 receptor can bind PGE2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760965", "l": "CDH11 gene is transcribed into nascent CDH11 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37788", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416698", "l": "SEMA5A binds to PLXNB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45415", "l": "H2O + prostaglandin D2-1-glycerol ester <=> glycerol + H(+) + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32283", "l": "3-hydroxyanthranilate + O2 = H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29121", "l": "a ubiquinone + H2O + nitrite => a ubiquinol + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74707", "l": "Binding of IRS to insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111870", "l": "Activation of PLC beta-1/4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482772", "l": "Release of platelet cytosolic components (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73011", "l": "L-leucine(in) = L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50038", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine => choloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404135", "l": "RBP4 binds atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32894", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 <=> alpha-pinene oxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18077", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) = H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.37", "l": "\"NAD(+)--dinitrogen-reductase ADP-D-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75621", "l": "ectocarpin C => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12997", "l": "(E)-feruloyl-CoA + galactarate = 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.130", "l": "\"galactarate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0090681", "l": "GPCR taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975175", "l": "MyD88 interacts with the activated TLR receptor 7, 8 or 9  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25474", "l": "diphosphate + gamma-himachalene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41822", "l": "3-oxohexanoyl-[ACP] + CO2 + holo-[ACP] => butanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42648", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O = (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59507", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) <=> [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64028", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030548", "l": "acetylcholine receptor regulator activity", "d": ["Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416516", "l": "GRK2 sequesters activated Gq (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869694", "l": "oxPL binds CD14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45806", "l": "ADP + L-glutamine hydroxamate + phosphate => ATP + hydroxylamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67552", "l": "3'-phosphoadenylyl sulfate + cholate = adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43310", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030748", "l": "amine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21381", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA => AMP + diphosphate + phytanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26407", "l": "H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61086", "l": "(2R,3R)-dihydrokaempferol + CO2 + succinate => (2S)-naringenin + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51863", "l": "(2E)-geranyl diphosphate + umbelliferone <=> 8-geranylumbelliferone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18507", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+) => L-lysine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23629", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45536", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47536", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isochenodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0009013", "l": "succinate-semialdehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660822", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44670", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15021", "l": "(E)-feruloyl-CoA + L-quinate = 4-O-feruloyl-D-quinate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.99", "l": "\"quinate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52166", "l": "(R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52203", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987214", "l": "p-STAT3 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10289", "l": "H2O + L-rhamnono-1,4-lactone => H(+) + L-rhamnonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63997", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56526", "l": "AH2 + heme d1 => A + dihydro-heme d1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73245", "l": "cirsimaritin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41372", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716913", "l": "ESR1 binds ESR1 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29959", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose = alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990538", "l": "xylan O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65947", "l": "AH2 + CTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21343", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 <=> 2 vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21642", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH => NADP(+) + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18078", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) => H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47715", "l": "trans-3-hydroxy-L-proline <=> cis-3-hydroxy-D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52943", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate <=> chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20035", "l": "penicillin N => isopenicillin N", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681980", "l": "ATG12 binds ATG7 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51149", "l": "a primary alcohol + 2 oxidized [azurin] => an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870465", "l": "RGGT binds the RAB-binding subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15275", "l": "3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52642", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15934", "l": "(S)-propane-1,2-diol + NAD(+) => (S)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75752", "l": "(9Z)-octadecenoate + H2O => 10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.18", "l": "\"lysine 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050287", "l": "sorbose 5-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34761", "l": "ADP + glycerol 2-phosphate(in) + H(+) + phosphate => ATP + glycerol 2-phosphate(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69142", "l": "Recruitment of Dna2 endonuclease (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57762", "l": "C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74409", "l": "2 (S)-lactate(out) + thromboxane B2(in) => 2 (S)-lactate(in) + thromboxane B2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65860", "l": "A + Delta(1)-dihydrotestosterone + H2O = 17beta-hydroxyandrostan-1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210805", "l": "Removal of miRNA passenger strand (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48188", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41792", "l": "holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.39", "l": "\"[acyl-carrier-protein] S-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016019", "l": "peptidoglycan immune receptor activity", "d": ["Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35572", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30889", "l": "7,8-dihydropteroate + H2O => 4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39662", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72253", "l": "(R)-metanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-adrenaline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16072", "l": "cytidine + H(+) + H2O <=> NH4(+) + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69040", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 = 2-nitrobutanedioate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950782", "l": "p-STAT1 binds p-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47878", "l": "a ganglioside GM1 + N-acetylneuraminate => a ganglioside GD1b + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.302", "l": "\"hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24765", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17541", "l": "an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.7", "l": "\"aryl-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75409", "l": "cortalcerone + H2O => 2-dehydro-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37055", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate = 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.111", "l": "\"4-hydroxyphenylpyruvate 3-dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21013", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57039", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102477", "l": "2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone = H+ + 6C-hexosyl chrysin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109813", "l": "GRB2-1 binds SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24927", "l": "H2O + L-cystine = NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": [], "t": []}, {"i": "EC:4.4.1.35", "l": "\"L-cystine beta-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757688", "l": "SERPINA6 binds PREDN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691174", "l": "RAC1 binds effectors at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229283", "l": "LCNs bind lipids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40139", "l": "(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10529", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56228", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332359", "l": "Active calmodulin binds CAMK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465883", "l": "VTN binds collagens I, IV and VI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.5", "l": "\"dissimilatory sulfite reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824268", "l": "Expression of HES7 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65517", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O => NH4(+) + pre-mycofactocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53969", "l": "apo-[BtrI ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44098", "l": "CoA + decanyl hexadecanoate => decan-1-ol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851908", "l": "Activated MET binds GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59598", "l": "3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+) => H2O + kynuramine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67007", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639286", "l": "RRAGC,D exchanges GTP for GDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30696", "l": "3-aminopropanal + H2O + NAD(+) => beta-alanine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901531", "l": "hypochlorite binding", "d": ["Binding to hypochlorite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263444", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51185", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O => H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77589", "l": "Recognition of AAUAAA sequence by CPSF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25324", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030760", "l": "pyridine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420206", "l": "Phosphorylation of SRC-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21162", "l": "ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39584", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508282", "l": "SYK is a substrate for JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70837", "l": "L-arginine(out) + L-glutamine(in) + Na(+)(in) => L-arginine(in) + L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008957", "l": "phenylacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75668", "l": "(11Z,14Z,17Z)-eicosatrienoate + O2 => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016964", "l": "alpha-2 macroglobulin receptor activity", "d": ["Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48815", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55119", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44836", "l": "a globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose = a globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18942", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) => a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942302", "l": "MMP13 cleaves OPTC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.510159133984757", "identifiers": [{"i": "GO:0015108", "l": "chloride transmembrane transporter activity", "d": ["Enables the transfer of chloride ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60703", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59451", "l": "dodecan-1-ol + NADP(+) <=> dodecanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204485", "l": "Basigin binds CyPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69793", "l": "D-phenylalanine + H(+) + tRNA(Phe) => D-phenylalanyl-tRNA(Phe) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614665", "l": "SQR oxidizes sulfide to bound persulfide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033977", "l": "2-haloacid dehalogenase (configuration-retaining) activity", "d": ["Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65158", "l": "CO2 + H2O + preaustinoid A3 + succinate => 2-oxoglutarate + O2 + preaustinoid A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33935", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008955", "l": "peptidoglycan glycosyltransferase activity", "d": ["Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170045", "l": "isopentenyl pyrophosphate transmembrate transporter activity", "d": ["Enables the transfer of isopentenyl pyrophosphate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69961", "l": "6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35290", "l": "ATP + chloramphenicol(in) + H2O <=> ADP + chloramphenicol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42714", "l": "5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(54) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43260", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2206299", "l": "Defective IDUA does not hydrolyse Heparan sulfate chain(6) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16309", "l": "H2O + taurochenodeoxycholate = chenodeoxycholate + taurine", "d": [], "t": []}, {"i": "EC:3.5.1.74", "l": "\"chenodeoxycholoyltaurine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.6", "l": "\"beta-ureidopropionase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23152", "l": "a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034228", "l": "ethanolamine transmembrane transporter activity", "d": ["Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine."], "t": []}, {"i": "RHEA:32747", "l": "ethanolamine(in) = ethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40470", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103031", "l": "L-Ala-D/L-Glu epimerase activity", "d": ["Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823995", "l": "Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20925", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine => a [peptide]-C-terminal amide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33241", "l": "aminoacetone + CO2 + NADH => L-threonine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50743", "l": "H2O + leukotriene C4 <=> glycine + leukotriene F4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12680", "l": "AH2 + Latia luciferin + 2 O2 <=> A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928608", "l": "LIMK phosphorylates CFL1, inactivating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446364", "l": "Migfilin interacts with VASP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69626", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052789", "l": "mannan 1,3-beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043780", "l": "cobalt-precorrin-5B C1-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635868", "l": "ub-GLI is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10571", "l": "luteolin + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683774", "l": "p-T68-CHEK2 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38641", "l": "1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46290", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052685", "l": "perillic acid-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690023", "l": "NUBPL binds 4Fe-4S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16596", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine <=> 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211193", "l": "Homodimerization  of DFF40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40365", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74723", "l": "Endosome acidification (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12414", "l": "(R)-glycerate + phosphate => (2R)-3-phosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56371", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61812", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose = dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10088", "l": "sucrose + UDP-alpha-D-galactose = 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.167", "l": "\"sucrose 6(F)-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29237", "l": "a menaquinol + NAD(+) => a menaquinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70955", "l": "H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56585", "l": "1,2-epoxypropane + H2O => propane-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21370", "l": "5-hydroxyisourate + H2O2 => H2O + O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000822", "l": "inositol hexakisphosphate binding", "d": ["Binding to inositol hexakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70534", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73945", "l": "FAS-mediated dimerization of procaspase-8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615626", "l": "PMP22 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0000146", "l": "microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15166", "l": "H2O + O2 + sarcosine => glyoxylate + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75182", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-axinyssene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50396", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": [], "t": []}, {"i": "EC:2.3.1.230", "l": "\"2-heptyl-4(1H)-quinolone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139918", "l": "Phosphorylation of BIM by JNK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299318", "l": "Activation of TASK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29968", "l": "2'-deoxyuridine(in) + H(+)(in) => 2'-deoxyuridine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65315", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72475", "l": "cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813740", "l": "GDE1 hydrolyzes GroPIns (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416723", "l": "SEMA6A binds to PLXNA2 and PLXNA4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215406", "l": "PRMT5 binds WDR77 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26535", "l": "3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658430", "l": "NF1 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18890", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74596", "l": "(2S,3R)-3-methyl-L-aspartate => mesaconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140933", "l": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013147", "l": "RAC1 GDIs block activation of RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20029", "l": "10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine", "d": [], "t": []}, {"i": "EC:1.1.1.273", "l": "\"vellosimine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000704", "l": "pyrimidine dimer DNA N-glycosylase activity", "d": ["Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17851", "l": "(2E)-butenoyl-CoA + H2O => (3R)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35692", "l": "(2S)-versicolorone + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216283", "l": "RDX binds to and ubiquitinates CI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191654", "l": "c-src associates with Cx43 in gap junctions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61599", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide <=> [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70971", "l": "citrate <=> isocitrate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629187", "l": "TP53 binds regulatory elements of SESN1,2,3 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55883", "l": "apo-[aequorin]--coelenterazine + O2 <=> [aequorin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44501", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972975", "l": "POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465940", "l": "atRAL is reduced to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70434", "l": "2 H(+)(out) + Li(+)(in) <=> 2 H(+)(in) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008490", "l": "arsenite secondary active transmembrane transporter activity", "d": ["Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64799", "l": "H2O + L-lysine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52884", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) = 2 H(+) + 2 NADPH + nitrobenzene", "d": [], "t": []}, {"i": "EC:1.7.1.16", "l": "\"nitrobenzene nitroreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65485", "l": "hexan-1-ol + hexanoyl-CoA => CoA + hexyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43649", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23333", "l": "(2R)-3-phosphoglycerate + GTP => (2R)-3-phospho-glyceroyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66640", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + koraiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43525", "l": "L-allo-threonine + NADP(+) => aminoacetone + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34410", "l": "3 ATP <=> 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428749", "l": "Activated TP receptor binds G-proten Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24154", "l": "3'-phosphoadenylyl sulfate + ADP + H(+) => adenosine 5'-phosphosulfate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72672", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 => 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429699", "l": "CERT1-2 complex binds ceramide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198669", "l": "p38MAPK phosphorylates MSK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12017", "l": "(2E,6E)-farnesyl diphosphate => (-)-germacrene D + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759358", "l": "NFE2L2-dependent SRXN1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31089", "l": "3-oxodecanoyl-CoA + CoA => acetyl-CoA + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22107", "l": "2-oxoglutarate + nicotianamine <=> 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70573", "l": "argininosuccinate <=> fumarate + arginine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14599", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43036", "l": "L-cysteine = 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52685", "l": "NAD(+) + pyridoxine => H(+) + NADH + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34008", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine => 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209924", "l": "Dopa is decarboxylated to dopamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683774", "l": "p-T68-CHEK2 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56930", "l": "abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611751", "l": "β1,2-agonists bind ADRB1,2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.64", "l": "\"mitochondrial processing peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20385", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005005", "l": "transmembrane-ephrin receptor activity", "d": ["Combining with a transmembrane ephrin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74418", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23670", "l": "AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase] => apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391377", "l": "Luteinizing hormone receptor can bind LH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40459", "l": "(2S)-pristanoyl-CoA + O2 = (2E)-pristenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14690", "l": "4-chlorophenylacetate + NADH + O2 => 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0046508", "l": "hydrolase activity, acting on carbon-sulfur bonds", "d": ["Catalysis of the hydrolysis of any carbon-sulfur bond, C-S."], "t": []}, {"i": "EC:3.13.-.-", "l": "\"Acting on carbon-sulfur bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76880", "l": "3-aminobutan-2-ol + H2O + NAD(+) => acetoin + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50548", "l": "prostaglandin E1 = H2O + prostaglandin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.15", "l": "\"D-iditol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55754", "l": "coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59301", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin => adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47541", "l": "7-oxolithocholate + H(+) + NADPH => NADP(+) + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49131", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23081", "l": "L-rhamnonate => 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34712", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63350", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016900", "l": "oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule."], "t": []}, {"i": "EC:1.1.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17160", "l": "ATP + creatine <=> ADP + H(+) + N-phosphocreatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805122", "l": "AURKB binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37875", "l": "aklanonate + S-adenosyl-L-methionine = methyl aklanonate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.288", "l": "\"aklanonic acid methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22396", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = glycolaldehyde + guaiacol + H2O + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70575", "l": "3',5'-cyclic UMP + H2O = H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173631", "l": "Activation of C1s (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74974", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) <=> L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61811", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP <=> AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48385", "l": "a 2,3-saturated fatty acid + H2O2 => a 3-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43055", "l": "3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34475", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.32", "l": "\"15-cis-phytoene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226979", "l": "ADD1:ADD2 binds DMTN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23735", "l": "(R)-5-diphosphomevalonate + ATP <=> ADP + CO2 + isopentenyl diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50970", "l": "inosine(37) in tRNA(Ala) + NH4(+) => adenosine(37) in tRNA(Ala) + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32362", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68700", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174444", "l": "Formation of C-strand Okazaki fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604752", "l": "Initial activation of proMMP13 by MMP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50204", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796043", "l": "NFE2L2 dependent BCL2L1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23977", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77465", "l": "(2S)-2-(furan-3-yl)-2-hydroxyacetonitrile => furan-3-carbaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167511", "l": "HLCS biotinylates ACACB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507719", "l": "p62:MEKK3 binds to TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24621", "l": "NAD(+) + octan-1-ol => H(+) + NADH + octanal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72342", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) <=> catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66926", "l": "[(R)-3-hydroxyalkanoate](n+1) + CoA => [(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009700", "l": "IL2RB and IL2RG are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.55", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247839", "l": "Retromer associates with WLS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399985", "l": "AKT1 E17K mutant phosphorylates caspase-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047045", "l": "testosterone 17-beta-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40247", "l": "H2O + rhodomycin D = 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51968", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60038", "l": "3-hydroxy-3-methylhexanoate + L-glutamine => H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55341", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol => 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22329", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) => diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564169", "l": "Collagen type VIII degradation by MMP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045516", "l": "interleukin-19 receptor binding", "d": ["Binding to an interleukin-19 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42836", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH = 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.236", "l": "\"5-methylnaphthoic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59877", "l": "(indol-3-yl)butanoate + ATP + L-cysteine => (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15667", "l": "H2O + N(6)-(D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57948", "l": "2-hydroxytoluene + H(+) + NADH + O2 = 3-methylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2512800", "l": "SCARB1:ligand is endocytosed (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22406", "l": "D-galactaro-1,5-lactone + H(+) + NADH => beta-D-galacturonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31266", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol <=> but-3-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61844", "l": "solasodine + UDP-alpha-D-glucose = H(+) + solasodine 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029451", "l": "Activation of RAC1 by VAV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0016749", "l": "N-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29798", "l": "ATP(in) + H2O(in) + Zn(2+)(out) <=> ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58943", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15992", "l": "(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033712", "l": "1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76610", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O <=> (12Z,15Z)-10-hydroxyoctadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42728", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA = 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.168", "l": "\"21S rRNA (uridine(2791)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928639", "l": "p-EFNB binds GRB4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033426", "l": "CAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944240", "l": "Association of procollagen type III (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20813", "l": "(3S)-citryl-CoA => acetyl-CoA + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70959", "l": "D-tyrosine + H2O + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009015", "l": "N-succinylarginine dihydrolase activity", "d": ["Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26206", "l": "4-nitrophenol + H(+) + NADPH + O2 => 4-nitrocatechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9680443", "l": "ROCK1,2 bind ROCKi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38642", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44143", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate <=> acetyl-CoA + CO2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352872", "l": "fructose 6-phosphate <=> glucose 6-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74471", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 = (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24509", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419465", "l": "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47744", "l": "demethylphylloquinone + H(+) + NADPH = demethylphylloquinol + NADP(+)", "d": [], "t": []}, {"i": "EC:1.6.5.12", "l": "\"demethylphylloquinone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785684", "l": "Fibronectin degradation by CTSG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64289", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] => cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106365", "l": "beta-carotene isomerase activity", "d": ["Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034564", "l": "4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity", "d": ["Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852331", "l": "GTSE1 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77199", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxy-5-cholenate = 3beta-sulfo-5-cholenate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67965", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine => 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48375", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61989", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27621", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate <=> di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21805", "l": "ATP + myo-inositol => 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482772", "l": "Release of platelet cytosolic components (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53925", "l": "a secondary amine + S-adenosyl-L-methionine => a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58373", "l": "(E)-oct-2-en-1-ol + NADP(+) => (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28124", "l": "ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+) => ATP + di-trans,octa-cis-undecaprenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102065", "l": "patchoulene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + gamma-patchoulene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15005", "l": "2-oxoglutarate + gibberellin A1 + O2 = CO2 + gibberellin A8 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.13", "l": "\"gibberellin 2beta-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71085", "l": "estrone 3-sulfate(in) + 2 Na(+)(in) => estrone 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749253", "l": "Formation of MCM2-7 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28959", "l": "D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40735", "l": "(20S)-ginsenoside Rb1 + 2 H2O = 2 D-glucose + gypenoside LXXV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29522", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21289", "l": "D-glucose + sn-glycerol 3-phosphate => D-glucose 6-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34398", "l": "L-phenylalanine <=> L-beta-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55858", "l": "all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34331", "l": "H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.168", "l": "\"indole-3-pyruvate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33863", "l": "menaquinone-7 + succinate = fumarate + menaquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730886", "l": "Phosphorylation of SHC by SYK kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67595", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O <=> (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16064", "l": "H2O + sn-glycerol 3-phosphocholine <=> choline + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19710", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76832", "l": "H2O + hexylamine + NAD(+) => H(+) + hexanal + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050013", "l": "2-dehydropantoate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.1", "l": "\"anthranilate 1,2-dioxygenase (deaminating, decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.979118784047927", "identifiers": [{"i": "GO:0140657", "l": "ATP-dependent activity", "d": ["A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659820", "l": "RB1 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61346", "l": "3-hydroxypyruvate + H2O2 + NH4(+) => H2O + L-serine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70551", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419452", "l": "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381608", "l": "cAMP activates EPAC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25117", "l": "H2O + L-lysine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34001", "l": "5alpha-cholesta-7,24-dien-3beta-ol => zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417114", "l": "Assembly of telomerase RNP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39104", "l": "ATP + H2O + sitosterol(in) => ADP + H(+) + phosphate + sitosterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50763", "l": "a quinone + H2O + sulfite <=> a quinol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647631", "l": "GSDMD (1-275) binds PIPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10516", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.166", "l": "\"hydroxycyclohexanecarboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54372", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.182", "l": "\"pristinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371467", "l": "SIRT1 deacetylates HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865182", "l": "OTUD7A hydrolyses K11diUb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68759", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22086", "l": "2 NH4(+) + pyruvate => (S)-2,3-diaminopropanoate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444516", "l": "Formation of MSH2:MSH6 Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59631", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine <=> 4-aminobutanoate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003838", "l": "sterol 24-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + zymosterol = fecosterol + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53919", "l": "an acyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18063", "l": "methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654125", "l": "Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562564", "l": "Caspase-8 processing within TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.28", "l": "\"picornain 3C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39605", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28071", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70966", "l": "D-phenylalanine + H2O + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.14", "l": "\"chitinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931981", "l": "RUNX1 binds ESR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14911", "l": "aldehydo-D-glucuronate + H(+) + NADPH => L-gulonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47004", "l": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23771", "l": "a fatty acyl-CoA + sphing-4-enine <=> an N-acylsphing-4-enine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21866", "l": "a 2-hydroxy carboxylate + glutathione + H(+) => an S-(2-hydroxyacyl)glutathione + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769383", "l": "CBY1 binds beta-catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354173", "l": "Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49457", "l": "(2S)-2-amino-4-deoxychorismate + H2O => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168886", "l": "Hemopexin binds Hemes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51018", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate => 7,8-dihydroneopterin 3'-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5604929", "l": "Activated protein C binds Protein S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43233", "l": "H2O + isatin => H(+) + isatinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20785", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine => ADP-D-ribose + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.2", "l": "\"DNA topoisomerase (ATP-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23787", "l": "a quinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22075", "l": "ATP + L-ribulose <=> ADP + H(+) + L-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2272795", "l": "Interaction of DAP12 and KIR2DS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11794", "l": "1,2-epoxypropane + H2O + NAD(+) => H(+) + NADH + O2 + propene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140068", "l": "histone crotonyltransferase activity", "d": ["Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51368", "l": "glycine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72180", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) => 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112395", "l": "Abortive termination of elongation after arrest (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35931", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033730", "l": "arogenate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352893", "l": "glucose 6-phosphate <=> fructose 6-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31137", "l": "5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58631", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV <=> FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66864", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + quiannulatene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849055", "l": "PTK6 binds ARHGAP35 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16198", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9009072", "l": "STAT3 phosphorylation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62423", "l": "a (R)-2-hydroxy fatty acid + O2 <=> a fatty acid + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52907", "l": "15,17(3)-seco-F430-17(3)-acid + ATP <=> ADP + coenzyme F430 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27664", "l": "2-oxoglutarate + H2O2 => (S)-2-hydroxyglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853444", "l": "AURKA phosphorylates PHLDA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754964", "l": "ADA deamidates RBV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65978", "l": "previtamin D3 => 7-dehydrocholesterol + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59077", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60582", "l": "18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77597", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35404", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) => (3R)-vestitone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036357", "l": "2-phosphoglycerate kinase activity", "d": ["Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933533", "l": "Dimerization of p-IRF7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203700", "l": "eNOS translocation from Golgi to Caveolae (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59665", "l": "D-cellopentaose + O2 => D-cellopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726621", "l": "PGR binds PGR antagonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21950", "l": "formate + NH4(+) => formamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39038", "l": "an omega-hydroxy fatty acid + NAD(+) <=> an omega-oxo fatty acid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004730", "l": "pseudouridylate synthase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955885", "l": "SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55173", "l": "2-oxoglutarate + hexanoyl-CoA + O2 => 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76433", "l": "Na(+)(in) + NH4(+)(out) => Na(+)(out) + NH4(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939201", "l": "ESR dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40128", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68376", "l": "glyoxylate + L-asparagine = 2-oxosuccinamate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-996755", "l": "ZFPM proteins bind GATA proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43020", "l": "L,L-cystathionine = 2-aminoprop-2-enoate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173778", "l": "MSR1 (SCARA1, SR-A) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196753", "l": "2xPPCS ligates PPanK with Cys (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16934", "l": "1-aminocyclopropane-1-carboxylate + H2O => 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.9", "l": "\"agaritine gamma-glutamyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13826", "l": "GDP-alpha-D-rhamnose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57787", "l": "1,4-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835328", "l": "NPM binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854466", "l": "VLDLR binds RELN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43570", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47198", "l": "a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004531", "l": "deoxyribonuclease II activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102862", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48768", "l": "ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.210", "l": "\"D-erythrulose 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222491", "l": "Lactoferrin scavenges iron ions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53990", "l": "L-threonyl-[myosin light chain] + phosphate => H2O + O-phospho-L-threonyl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63123", "l": "(11Z)-eicosenamide + H2O <=> (11Z)-eicosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851011", "l": "TRIM27 polyubiquitinates PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27645", "l": "adenosine + phosphate <=> adenine + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794523", "l": "SLC22A1 transports Cipro into renal cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050252", "l": "retinol O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12932", "l": "2-oxoglutarate + acetyl-CoA + H2O <=> (2R)-homocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047327", "l": "glycerol-3-phosphate-glucose phosphotransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781905", "l": "ZRANB1 binds APC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796626", "l": "MIB2 ubiquitinates CFLAR  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202731", "l": "JAM3 dimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54830", "l": "formaldehyde + H2O + methylamine + NADP(+) => dimethylamine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45394", "l": "(9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41269", "l": "(15Z)-tetracosenoate + sphing-4-enine => H2O + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686410", "l": "BLM mediates dissolution of double Holliday junction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13701", "l": "acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine", "d": [], "t": []}, {"i": "EC:2.3.1.31", "l": "\"homoserine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381087", "l": "Dimerization of PERK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65534", "l": "2-methylbutyl hexanoate + CoA => 2-methylbutan-1-ol + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33809", "l": "2-methoxy-4-vinylphenol + CO2 => (E)-ferulate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41746", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036055", "l": "protein-succinyllysine desuccinylase activity", "d": ["Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:47668", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013110", "l": "RHOC binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791349", "l": "TP53 binds the APAF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69098", "l": "H2O + kynurenate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18043", "l": "8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789092", "l": "NOX2 generates superoxide anion from oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43524", "l": "L-allo-threonine + NADP(+) = aminoacetone + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.381", "l": "\"3-hydroxy acid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60725", "l": "dodecanal + H2O + NADP(+) => dodecanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52902", "l": "15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate => 3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465924", "l": "OPN1LW binds 11cRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68265", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317314", "l": "AKT binds PDPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72274", "l": "formate(out) + oxalate(in) <=> formate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66740", "l": "ATP + H2O + N-acetyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.261", "l": "\"(4-hydroxyphenyl)alkanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32217", "l": "(6S)-NADHX => (6R)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63321", "l": "a glycerophospholipid(in) + ATP + H2O => a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432544", "l": "Phosphorylated PER transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626549", "l": "IQGAPs bind CALM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032428", "l": "beta-N-acetylgalactosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448958", "l": "Nuclear translocation of p38 MAPK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47232", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18955", "l": "H(+) + NADPH + sepiapterin => L-erythro-7,8-dihydrobiopterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564169", "l": "Collagen type VIII degradation by MMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.335", "l": "\"4-amino-anhydrotetracycline N(4)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29923", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75441", "l": "14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40028", "l": "9alpha-copalyl diphosphate + H2O => (13S)-vitexifolin A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71464", "l": "H2O + substance P => Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.87", "l": "\"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046553", "l": "D-malate dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: (R)-malate + NAD+ = CO2 + NADH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37141", "l": "1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42813", "l": "cholesterol + octadecanoyl-CoA => cholesteryl octadecanoate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67791", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48897", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57735", "l": "A + all-trans-7,8-dihydroretinol <=> AH2 + all-trans-retinol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43768", "l": "an alkylamine + L-glutaminyl-[protein] = N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805103", "l": "AURKA phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102631", "l": "caffeoylglucose 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine = 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60744", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11790", "l": "H(+) + NADH + NH4(+) + oxaloacetate => H2O + L-aspartate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404200", "l": "IGF1,2 binds IGF1R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044103", "l": "L-arabinose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+."], "t": []}, {"i": "EC:1.1.1.376", "l": "\"L-arabinose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44780", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine = H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41421", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 => CO2 + grixazone B + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65540", "l": "a ganglioside GM3 + H2O = an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64785", "l": "S-ethyl-L-cysteine => 2-aminoprop-2-enoate + ethanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74986", "l": "Elongation of pre-rRNA transcript (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10886", "l": "acetaldehyde + desmosterol => (24R,24(1)R)-fucosterol epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.151", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58189", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O => dihydroisopentenyldehydrorhodopin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749609", "l": "BCHE hydrolyzes ASA- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57737", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol => AH2 + all-trans-3,4-didehydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072587", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity", "d": ["Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40927", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28152", "l": "CoA + H(+) + N(1)-acetylspermidine => acetyl-CoA + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0035757", "l": "chemokine (C-C motif) ligand 19 binding", "d": ["Binding to chemokine (C-C motif) ligand 19."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374665", "l": "DCC interaction with SIAH1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724745", "l": "PLG(20-810) binds aprotinin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70692", "l": "ornithine => putrescine + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12300", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) = 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53582", "l": "20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56934", "l": "17beta-hydroxy-androst-5-en-3-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40033", "l": "diphosphate + ent-manool => ent-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004904", "l": "interferon receptor activity", "d": ["Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49731", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NADP(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388596", "l": "Melanocortin receptors bind melanocortins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38208", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42650", "l": "(2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+) => (2,5-ethylene furandicarboxylate)(n) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931981", "l": "RUNX1 binds ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19239", "l": "4-carboxymethyl-3-methylbut-2-en-1,4-olide => 4-carboxymethyl-4-methylbut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58559", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16S)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48872", "l": "a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.190", "l": "\"aminoglycoside 2''-phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63982", "l": "4-thiouridine 5'-phosphate + ADP + H(+) => 4-thiouridine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62066", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH => 2-deoxy-D-glucose 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710263", "l": "GZMB cleaves GSDME (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71926", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) <=> 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109700", "l": "AKT2 binds PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.63", "l": "\"pseudobaptigenin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070009", "l": "serine-type aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19550", "l": "H2O + o-orsellinate depside => H(+) + 2 orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015043", "l": "leghemoglobin reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72084", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O => ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57680", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.76", "l": "\"flavone synthase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66173", "l": "H(+)(out) + L-cystine(out) => H(+)(in) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63895", "l": "ATP + H2O + L-tryptophan <=> AMP + D-tryptophan + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41638", "l": "1-O-(1Z-alkenyl)-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15043", "l": "inulobiose => bis-D-fructose 2',1:2,1'-dianhydride + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69211", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25567", "l": "H2O + N-acetyl-4-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009558", "l": "IL34 dimer binds SDC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37279", "l": "ATP + H2O + L-alanyl-L-histidine(out) = ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010013", "l": "N-1-naphthylphthalamic acid binding", "d": ["Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.186", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15726", "l": "1,5-anhydro-D-fructose => ascopyrone M + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60193", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391372", "l": "GNRHR binds GNRH1,2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675417", "l": "PEBP1 binds activated RAF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702849", "l": "CALCR binds gepants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60158", "l": "ADP + D-galactose(in) + H(+) + phosphate => ATP + D-galactose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11234", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + sulfate => 3'-phosphoadenylyl sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75729", "l": "(10S)-hydroxy-(12Z)-octadecenoate => (10E,12Z)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34478", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> 15-cis-phytoene + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44214", "l": "3-hydroxytetradecanoyl-CoA + AMP + diphosphate => 3-hydroxytetradecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58717", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin => FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050034", "l": "L-rhamnose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamnono-1,4-lactone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668398", "l": "CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76024", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30857", "l": "(S)-2,3-epoxysqualene + H2O => dammarenediol-II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694737", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16223", "l": "3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38465", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938121", "l": "SERPINB13 binds CTSK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44512", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050535", "l": "beta-primeverosidase activity", "d": ["Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218847", "l": "PAK2 binds NCK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418858", "l": "RhoGTPase GEF's recruited to DCC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21840", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29164", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) => 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43544", "l": "ATP + L-glutamate + tyramine = ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.24", "l": "\"tyramine--L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005528", "l": "FK506 binding", "d": ["Binding to a 23-membered macrolide lactone FK506."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15117", "l": "3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": [], "t": []}, {"i": "EC:2.4.2.52", "l": "\"triphosphoribosyl-dephospho-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19167", "l": "1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23267", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0005506", "l": "iron ion binding", "d": ["Binding to an iron (Fe) ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813626", "l": "LEAP2 binds bacteria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74707", "l": "Binding of IRS to insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44510", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28272", "l": "CoA + H(+) + N(8)-acetylspermidine => acetyl-CoA + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38256", "l": "(S)-malate + succinyl-CoA => (S)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33375", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH = a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38421", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28541", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59113", "l": "ATP + L-serine => ADP + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55363", "l": "11-cis-retinol <=> 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577259", "l": "MSH2 variant:MSH3-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25059", "l": "(E)-cinnamate + H(+) + NADH + O2 => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14654", "l": "a nucleoside 3',5'-cyclic phosphate + H2O => a nucleoside 5'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867613", "l": "PICALM binds R-SNAREs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34158", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.6", "l": "\"endo-1,3(4)-beta-glucanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68068", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27490", "l": "2 D-sedoheptulose 7-phosphate => D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938121", "l": "SERPINB13 binds CTSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112037", "l": "Inactivation of PLC beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52184", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50476", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015369", "l": "calcium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011958", "l": "miR-26A and B bind to the 3'UTR of the GREB1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53541", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27743", "l": "2'-deoxyadenosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63454", "l": "GMP + H(+) + oxidized 3PG-factor420-0 => 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75797", "l": "Na(+)(in) + nicotinate(in) => Na(+)(out) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.3", "l": "\"citrate (Re)-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815510", "l": "MIB2 binds CYLD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44538", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42574", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76582", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADPH <=> (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76879", "l": "3-aminobutan-2-ol + H2O + NAD(+) = acetoin + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47403", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA <=> (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10282", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => 1,7-dimethylxanthine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033908", "l": "beta-L-rhamnosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247836", "l": "Retromer recycles WLS to the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.182", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372819", "l": "PCK2 phosphorylates OA to yield PEP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661425", "l": "BIL:ALB dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45992", "l": "(3R)-3-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030563", "l": "snRNA 2'-O-ribose methylation guide activity", "d": ["Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35581", "l": "anthocyanin A11 + D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56884", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018804", "l": "RAC3 GEFs activate RAC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70510", "l": "LDH tetramer oxidises LACT to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683583", "l": "ATG10:ATG12:ATG7 dimer dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57050", "l": "2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase] => AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139909", "l": "Translocation of BMF to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373730", "l": "Neurofascin and NrCAM heterodimerization (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74925", "l": "a (2E)-enoyl-[ACP] + glycine + H2O => a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.257", "l": "\"N-terminal L-serine N(alpha)-acetyltransferase NatD\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52578", "l": "(2E)-hexenoyl-CoA + H(+) + NADH => hexanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695949", "l": "SPHK2 phosphorylates sphingoid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676257", "l": "Formation of the SET1A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377640", "l": "Autophosphorylation of SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70899", "l": "histidine => urocanate + NH4+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32331", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) = (1S,4R)-fenchone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26046", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-9-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931981", "l": "RUNX1 binds ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669023", "l": "TWEAK binds FN14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9833777", "l": "PKR binds activating host RNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60082", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77163", "l": "H(+) + hercynine + N-acetyl-1-seleno-beta-D-glucosamine + O2 = H2O + hercynyl-SeGlcNAc selenoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61776", "l": "rebaudioside D + UDP-alpha-D-glucose = H(+) + rebaudioside M + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43296", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52574", "l": "(2E)-butenoyl-CoA + H(+) + NADH => butanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47639", "l": "H2O + L-arginine + NADP(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38512", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047007", "l": "pregnan-21-ol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + pregnan-21-ol = H+ + NADH + pregnan-21-al."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735143", "l": "NKX2-5 binds the GATA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875816", "l": "STAT3 binds activated MET receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70044", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015161", "l": "lipid III floppase activity", "d": ["Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44627", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65562", "l": "H2O + kynurenate + L-glutamate => 2-oxoglutarate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29244", "l": "H(+) + menaquinone-8 + NADH => menaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11298", "l": "2-oxoglutarate + 2 H(+) + NADPH => 2,5-dioxopentanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19614", "l": "dimethyl sulfide + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + trimethylsulfonium", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032863", "l": "CDK5 phosphorylates NTRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42793", "l": "cholesterol + hexadecanoyl-CoA => cholesteryl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48134", "l": "(2E,6E)-farnesol + phosphate => (2E,6E)-farnesyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20209", "l": "ATP + xylitol = ADP + H(+) + xylitol 5-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.122", "l": "\"xylitol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70750", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23396", "l": "H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": [], "t": []}, {"i": "EC:3.7.1.4", "l": "\"phloretin hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16965", "l": "(2E)-geranyl diphosphate = beta-myrcene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.15", "l": "\"myrcene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73688", "l": "dAMP(out) + phosphate(in) => dAMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62028", "l": "H2O + stigmasteryl 3-beta-D-glucoside = D-glucose + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378975", "l": "Follitropin is a heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033435", "l": "AUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0047134", "l": "protein-disulfide reductase (NAD(P)) activity", "d": ["Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52134", "l": "a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35880", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35211", "l": "dIDP + H2O = dIMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68936", "l": "ATP + H(+) + NADPH + nonanoate = AMP + diphosphate + NADP(+) + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786190", "l": "CMBL hydrolyses OM to OLMS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696605", "l": "USP12, USP26 deubiquitinate AR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65017", "l": "chlorothalonil + H2O => 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748991", "l": "XDH oxidises 6MP to 6TU (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030281", "l": "structural constituent of cutaneous appendage", "d": ["The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37900", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 => 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382058", "l": "Nck binds to the active PDGF receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38091", "l": "delta-tocotrienol + S-adenosyl-L-methionine = beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50648", "l": "2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77023", "l": "D-glutamate + H2O + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68147", "l": "ethyl 3-oxobutanoate + H(+) + NADPH <=> ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948136", "l": "ULK1 Translocates to the mitochondria (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411402", "l": "Activation of NLK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74715", "l": "Autophosphorylation of insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61241", "l": "H2O + L-phenylalanine + O2 => 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32472", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] => (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18791", "l": "D-galactosamine 6-phosphate => D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48685", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65621", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19453", "l": "2-oxoglutarate + L-alanine = L-glutamate + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.2", "l": "\"alanine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102999", "l": "UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene = 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047092", "l": "27-hydroxycholesterol 7-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183126", "l": "Factor B binds to surface-associated C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46773", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38502", "l": "a triacyl-sn-glycerol + H2O <=> a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799335", "l": "Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46194", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63762", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41568", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67221", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73950", "l": "(2E)-geranyl diphosphate <=> (4E,6E)-allo-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670156", "l": "PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14892", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate <=> (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0005501", "l": "retinoid binding", "d": ["Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55836", "l": "calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672961", "l": "PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22869", "l": "3-chloro-L-alanine + thioglycolate => chloride + H(+) + S-carboxymethyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49611", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65228", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57812", "l": "1-chloro-2-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140545", "l": "ATP-dependent protein disaggregase activity", "d": ["An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351871", "l": "Caspase-mediated cleavage of Z0-2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879222", "l": "MDP:NLRP1 binds ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.13", "l": "\"(6-4)DNA photolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32256", "l": "meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15770", "l": "adenosylcob(III)inamide + ATP => adenosylcob(III)inamide phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730599", "l": "Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42753", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44466", "l": "a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48557", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034188", "l": "apolipoprotein A-I receptor activity", "d": ["Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73008", "l": "D-arabinose 5-phosphate => D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088298", "l": "FOXM1 stimulates CCNB1 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49326", "l": "all-trans-capsorubin => (5R,6S)-5,6-epoxi-capsanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69968", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) => Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.23", "l": "\"mucorpepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44060", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790038", "l": "Expression of HSP90B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47046", "l": "acetoacetate + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnitine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351207", "l": "Spermine  => N-acetylated spermine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418904", "l": "A1 and A3 receptors bind adenosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54803", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71285", "l": "chloride(in) + L-glutamine(in) + 2 Na(+)(in) => chloride(out) + L-glutamine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35935", "l": "2 ATP + L-proline + L-tryptophan = 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29639", "l": "D-maltohexaose + H2O = alpha-D-glucose + D-maltopentaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30510", "l": "2-demethylmenaquinone-8 + H(+) + NADH <=> 2-demethylmenaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67664", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836435", "l": "p-PKR dimer phosphorylates SNCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388833", "l": "Phosphorylation of CTLA-4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60698", "l": "(R)-lavandulol + diphosphate => (R)-lavandulyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23516", "l": "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.31", "l": "\"glycerate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693071", "l": "BACE1 translocates from ER lumen to Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61159", "l": "3'-dephospho-CoA + GTP <=> CoA + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20676", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16470", "l": "(R)-2-benzylsuccinate + succinyl-CoA => (R)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45945", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047985", "l": "hydrogen dehydrogenase activity", "d": ["Catalysis of the reaction: H2 + NAD+ = H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10485", "l": "H2O + N-feruloylglycine => (E)-ferulate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53077", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine => 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061486", "l": "high-affinity fructose transmembrane transporter activity", "d": ["Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29074", "l": "a ubiquinone + formate + H(+) <=> a ubiquinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30880", "l": "H2O + NAD(+) + prop-2-ynal => 2 H(+) + NADH + propynoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13391", "l": "(2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein] => glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549304", "l": "OCT3 mediates renal clearance of organic cations (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855047", "l": "Hydrolysis of internal thioester in C4b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12284", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190263", "l": "FGFR3b binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047090", "l": "benzoyl-CoA 3-monooxygenase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + H+ + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25988", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869694", "l": "oxPL binds CD14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0141058", "l": "histone H4 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821368", "l": "AKAP8L binds MLL1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44079", "l": "ATP + CoA + pentadecanoate <=> AMP + diphosphate + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27424", "l": "(2E,6E)-farnesyl diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19297", "l": "ATP + beta-alanine + L-histidine = ADP + carnosine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72381", "l": "chloride(in) + iodide(out) => chloride(out) + iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130706", "l": "MHC class II antigen processing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654425", "l": "Activated FGFR4 binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17445", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.12.7.2", "l": "\"ferredoxin hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55523", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate <=> 3 diphosphate + nerylneryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028730", "l": "Activated NTRK2 binds FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45662", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42307", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39042", "l": "an omega-oxo fatty acid + H2O + NAD(+) <=> a dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865454", "l": "CBFB binds RUNX3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187382", "l": "Degradation of ubiquitinated SMAD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164832", "l": "ATPase synthesizes ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.120", "l": "\"cyclohexane-1-carbonyl-CoA reductase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77330", "l": "L-ornithine + pyruvate <=> 5-amino-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16695", "l": "(Z)-2-methyl-5-isopropylhexa-2,5-dienal => alpha-pinene oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10570", "l": "H(+) + luteolin 7-O-beta-D-glucuronide + UDP => luteolin + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.62", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004043", "l": "L-aminoadipate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614933", "l": "ACEIs bind ACE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609739", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2C (GRIN2C) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679266", "l": "Beclin-1 complex translocates to the ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77228", "l": "AH2 + gentamicin X2 + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + geneticin + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33974", "l": "5''-phosphoribostamycin + H2O <=> phosphate + ribostamycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30017", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20736", "l": "acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.29", "l": "\"glycine C-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034906", "l": "N-isopropylaniline 1,2-dixoxygenase activity", "d": ["Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60316", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36290", "l": "H(+) + NADPH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678925", "l": "NR3C1 binds NR3C1 agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65377", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25459", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-humulene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12526", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022894", "l": "Intermediate conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19673", "l": "1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.35", "l": "\"pyrogallol 1,2-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37959", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783880", "l": "PIPOX oxidises PPCA to P6C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75926", "l": "(S)-4-aminopentanoate + H2O + NAD(+) <=> 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73584", "l": "CTP(out) + UDP(in) => CTP(in) + UDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702818", "l": "CALCR binds erenumab (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17902", "l": "S-adenosyl-L-methionine + xanthotoxol => H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.64", "l": "\"testosterone 17beta-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35314", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) <=> 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21814", "l": "7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17800", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042164", "l": "interleukin-12 alpha subunit binding", "d": ["Binding to the alpha subunit of interleukin-12."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953013", "l": "E2F7 binds E2F8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51066", "l": "adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate => 3'-phosphoadenylyl sulfate + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811427", "l": "COPI vesicle uncoating at the ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23474", "l": "alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose => 2 alpha,alpha'-trehalose 6-mycolate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16780", "l": "ATP + H2O + K(+)(out) <=> ADP + H(+) + K(+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031718", "l": "type 1 cannabinoid receptor binding", "d": ["Binding to a type 1 cannabinoid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67270", "l": "sch 210972 => (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213200", "l": "Release of endostatin-like peptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27283", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73806", "l": "AIR + CO2 => CAIR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65826", "l": "dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64699", "l": "benzyl alcohol + NAD(+) <=> benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021952", "l": "RBFOX1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31650", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16664", "l": "fluoride + S-adenosyl-L-methionine <=> 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853762", "l": "RET dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75301", "l": "2'cADPR + H(+) + nicotinamide => NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77418", "l": "(2E)-but-2-enal + hydrogen cyanide <=> (2S,3E)-2-hydroxypent-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445705", "l": "Release Of ADP From Myosin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54656", "l": "linalool = (2E)-geraniol", "d": [], "t": []}, {"i": "EC:5.4.4.8", "l": "\"linalool isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102629", "l": "patuletin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: patuletin + S-adenosyl-L-methionine = quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112604", "l": "Phosphorylated STATs are released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163090", "l": "Elongation Of The Telomeric Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610717", "l": "PKA phosphorylates GLI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26238", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeraniol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69607", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": [], "t": []}, {"i": "EC:2.3.1.308", "l": "\"tubulin N-terminal N-acetyltransferase NAT9\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26175", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA <=> CoA + H(+) + mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45219", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] <=> Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76231", "l": "2-oxoglutarate(in) = 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51208", "l": "20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76560", "l": "1-(ergostan-3beta-yl)-L-aspartate + H2O => ergosterol + H(+) + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64381", "l": "3 A + phytyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71422", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9010815", "l": "SLITs bind keratan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74996", "l": "epierythrostominol(in) => epierythrostominol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67215", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 <=> (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62015", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20741", "l": "H2O + trans-2,3-epoxysuccinate => (2R,3S)-tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71387", "l": "L-pipecolate(in) + Na(+)(in) = L-pipecolate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032426", "l": "NTRK2 phosphorylates FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30944", "l": "FAD + H(+) + octanoyl-CoA => (2E)-octenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334794", "l": "FABPs bind LCFAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251942", "l": "Hikeshi binds HSP70s:ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71216", "l": "2 Na(+)(out) + thiocyanate(out) => 2 Na(+)(in) + thiocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55270", "l": "(R)-glycerate + alpha-D-glucose 1-phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247837", "l": "WNT ligands traffic to the Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14277", "l": "(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.22", "l": "\"lactaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25535", "l": "ent-copalyl diphosphate <=> diphosphate + ent-cassa-12,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35871", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52182", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905060", "l": "calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682598", "l": "ATM phosphorylates HERC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18150", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate => acetate + D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50604", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": [], "t": []}, {"i": "EC:2.3.1.259", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatF\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68790", "l": "(Z)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52794", "l": "Mg(2+) + pheophorbide a => chlorophyllide a + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396399", "l": "Fibrillins bind BMPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45774", "l": "[(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->4)-beta-D-mannosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11878", "l": "15-oxoprostaglandin E2 + H(+) + NADH => NAD(+) + prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26081", "l": "(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.40", "l": "\"(Z)-gamma-bisabolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59157", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43871", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62165", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O => D-glucosamine + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33749", "l": "a 1-acyl-sn-glycero-3-phosphate + ADP + H(+) => a 1-acyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57496", "l": "2-methylcitrate = 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50392", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.149", "l": "\"lycopene elongase/hydratase (flavuxanthin-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244643", "l": "STING binds cyclic GMP-AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445079", "l": "Phosphorylation of L1 by ERK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65682", "l": "a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015488", "l": "glucuronide:cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57291", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O <=> a guanosine in RNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65543", "l": "a ganglioside GM3 + H2O <=> an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52266", "l": "gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805276", "l": "CDK5 phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50635", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26322", "l": "resorcinol + S-adenosyl-L-methionine => 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209200", "l": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49556", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047188", "l": "aromatic-hydroxylamine O-acetyltransferase activity", "d": ["Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678822", "l": "Defective CFTR does not transport Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170846", "l": "TGFBR2 recruits TGFBR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66758", "l": "ADP + domoate(out) + H(+) + phosphate => ATP + domoate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785245", "l": "Defective CYP11B2 does not oxidise CORST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22422", "l": "2 H(+) + maleylacetate + NADH => cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638006", "l": "ARL3 hydrolyzes GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57083", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481009", "l": "Exocytosis of platelet dense granule content (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23989", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56942", "l": "2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317314", "l": "AKT binds PDPK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47994", "l": "H(+)(out) + NADH + NADP(+) => H(+)(in) + NAD(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813749", "l": "ALDH1A1 oxidises GA to DGA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855111", "l": "VLDLR binds PCSK9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54374", "l": "(+)-(2S,3R,9R)-pristinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43893", "l": "[sulfur carrier]-H + L-cysteine => [sulfur carrier]-SH + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432010", "l": "Aquaporin-1 passively transports water into cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47757", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545253", "l": "Deacetylation of cohesin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9815510", "l": "MIB2 binds CYLD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69715", "l": "(indol-3-yl)acetate + ATP + CoA = (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.75", "l": "\"indoleacetate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11157", "l": "H2O + L-valine + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008765", "l": "UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29868", "l": "AMP + ITP => ADP + IDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47842", "l": "(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate => [5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22381", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O => [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.16", "l": "\"2',3'-cyclic-nucleotide 2'-phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13137", "l": "cycloartenol + S-adenosyl-L-methionine = cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.142", "l": "\"cycloartenol 24-C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197958", "l": "FPGS-2 transforms THF to THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166015", "l": "Association of LBP with LPS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853915", "l": "VENTX binds the TP53 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66342", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63888", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170674", "l": "Dissociation of the Gi alpha:G olf complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35304", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) => 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002952", "l": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity", "d": ["Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70424", "l": "an acyl-CoA + H2O => a carboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140571", "l": "transmembrane ascorbate ferrireductase activity", "d": ["Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008494", "l": "translation activator activity", "d": ["Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811479", "l": "ING2 recruits EP300 to TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50833", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800035", "l": "IGFBP3 binds TMEM219 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45937", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61225", "l": "H2O + L-asparagine + O2 => 2-oxosuccinamate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25246", "l": "(R)-S-lactoylglutathione + H2O => (R)-lactate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990833", "l": "clathrin-uncoating ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66620", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689861", "l": "Recruitment of XPA and release of CAK  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11692", "l": "NAD(+) + NADPH = NADH + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022911", "l": "CSPG is secreted (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014294", "l": "RAC2 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56067", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0031543", "l": "peptidyl-proline dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43553", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66996", "l": "2-methylpentanoate + ATP + CoA = 2-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791109", "l": "GADD45A binds PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707586", "l": "FeHM oxidises LDL,HDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21631", "l": "17alpha-hydroxyprogesterone + NADPH + O2 <=> acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16061", "l": "H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}, {"i": "EC:3.1.4.2", "l": "\"glycerophosphocholine phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35333", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25001", "l": "H(+) + N,N-dihydroxy-L-phenylalanine => (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25467", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + longifolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102215", "l": "thiocyanate methyltransferase activity", "d": ["Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine = methyl thiocyanate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25273", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.37", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73800", "l": "SAICAR => AICAR + Fumarate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70352", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428752", "l": "Dissociation of the TP:Gq complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47950", "l": "phosphate + thiamine => H2O + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50751", "l": "H2O + juglone <=> naphthalene-1,2,4,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75827", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35282", "l": "acetyl-CoA + hexadecanoyl-CoA <=> 3-oxooctadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404142", "l": "atROL binds RBP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0051723", "l": "protein methylesterase activity", "d": ["Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol."], "t": []}, {"i": "REACT:R-HSA-5367022", "l": "DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71332", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) => chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004114", "l": "3',5'-cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38699", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210881", "l": "Dimerization of Tie2/Ang1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795473", "l": "PDPK1 phosphorylates SGK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728664", "l": "GLP1R binds GLP1R agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140927", "l": "cyclic-di-GMP transmembrane transporter activity", "d": ["Enables the transfer of cyclic-di-GMP from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34889", "l": "selenate(out) => selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75660", "l": "(11Z,14Z)-eicosadienoate + O2 => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202328", "l": "Translocation of PKC theta to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.10", "l": "\"pyrimidine-5'-nucleotide nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52570", "l": "epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => epitestosterone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804402", "l": "TP53 binds POU4F1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-451418", "l": "Pellino ubiquitinates IRAK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42966", "l": "pseudouridine(54/55) in tRNA => uridine(54/55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197588", "l": "NICD2 binds RBPJ and MAML in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28831", "l": "D-gluconate(in) + H(+)(in) = D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928627", "l": "EPHB phosphorylates TIAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016155", "l": "formyltetrahydrofolate dehydrogenase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52341", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] => AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56671", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247847", "l": "WLS is endocytosed to the early endosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43843", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507871", "l": "Aquaporins passively transport glycerol out of cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102510", "l": "pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57077", "l": "3-oxoisoapionate 4-phosphate + H2O => (2R)-3-phosphoglycerate + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14520", "l": "(E)-feruloyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36242", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13718", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) => 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28198", "l": "(S)-1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.311", "l": "\"(S)-1-phenylethanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23514", "l": "beta-D-glucose 1-phosphate + D-glucose => alpha,alpha-trehalose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654573", "l": "Activated FGFR1 binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852552", "l": "MST1R autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76737", "l": "3-decanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decane + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038062", "l": "protein tyrosine kinase collagen receptor activity", "d": ["Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045437", "l": "uridine nucleosidase activity", "d": ["Catalysis of the reaction: H2O + uridine = ribofuranose + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30750", "l": "FAD + H(+) + hexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58428", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25400", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655825", "l": "SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015024", "l": "glucuronate-2-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532549", "l": "MPI isomerises Fru6P to Man6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662608", "l": "MT2A binds cadmium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696457", "l": "BDH2 dehydrogenates 3HBA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917700", "l": "MVB Vesicle Formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389862", "l": "Conversion of glyoxylate to oxalate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981622", "l": "Myoglobin:oxygen dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034548", "l": "N-cyclopropylammeline deaminase activity", "d": ["Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18438", "l": "4-CDP-2-C-methyl-D-erythritol + ATP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871227", "l": "RET binds GFRA4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21510", "l": "H(+) + hexadecanoate + retinol => all-trans-retinyl hexadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022869", "l": "protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49256", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] = 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.203", "l": "\"protein-N(pi)-phosphohistidine--D-glucosaminate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176956", "l": "Formation of GINS complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31989", "l": "baruol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16399", "l": "D-glucose + D-glucose 1,6-bisphosphate => 2 D-glucopyranose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42158", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => androsterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388809", "l": "CTLA-4 binds B7-1/B7-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42789", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0003796", "l": "lysozyme activity", "d": ["Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61758", "l": "H(+) + rebaudioside A + UDP => stevioside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48944", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54622", "l": "2-hydroxyeicosanoyl-CoA + CO2 + succinate => 2-oxoglutarate + eicosanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9716913", "l": "ESR1 binds ESR1 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35251", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752951", "l": "LHX2, LDB1, and EBF1 bind Olfactory Receptor gene and intergenic olfactory enhancers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707523", "l": "Hemes bind to BACH1:MAFK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854466", "l": "VLDLR binds RELN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008740", "l": "L-rhamnose isomerase activity", "d": ["Catalysis of the reaction: L-rhamnose = L-rhamnulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69580", "l": "dGMP + inosine = 2'-deoxyguanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033848", "l": "N2-(2-carboxyethyl)arginine synthase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75129", "l": "codeinone => neopinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296233", "l": "T2Rs bind bitter-tasting compounds (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16701", "l": "17alpha-estradiol + NAD(+) = estrone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801675", "l": "PLK2 phosphorylates NPM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40272", "l": "O2 + tetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785213", "l": "LIPC dimer binds heparin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102672", "l": "fatty acid alpha-oxygenase activity", "d": ["Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid = a 2(R)-hydroperoxy fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9816369", "l": "Expression of DUX4 in the zygote (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28569", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP <=> 6 AMP + enterobactin + 7 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871373", "l": "BMX phosphorylates RUFY1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10983", "l": "L-serine <=> D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677050", "l": "Formation of the GCN5-ATAC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20039", "l": "aldehydo-D-glucose 6-phosphate + H(+) + NADPH => D-sorbitol 6-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157937", "l": "NICD3 traffics to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950183", "l": "IL12B binds IL23A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0061133", "l": "endopeptidase activator activity", "d": ["Binds to and increases the activity of an endopeptidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44537", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37180", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate => (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27887", "l": "2',3'-cyclophospho-AMP + H2O => 3'-AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61544", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656893", "l": "OPN1MW binds 11cRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24310", "l": "7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956639", "l": "RUNX1 binds YAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64109", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016167", "l": "glial cell-derived neurotrophic factor receptor activity", "d": ["Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60149", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799326", "l": "Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047821", "l": "D-glutamate oxidase activity", "d": ["Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22772", "l": "L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.68", "l": "\"L-fuconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198983", "l": "NKG2D homodimer interacting with ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57837", "l": "H2O + O2 + thermospermine => 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66472", "l": "(2Z,6E,10E,14E)-geranylfarnesol = 18-episcalar-17(25)-en-19-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051566", "l": "anthocyanidin-3-glucoside rhamnosyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56345", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose => a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429036", "l": "SLC2A9 transports Fru, Glc, urate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351876", "l": "Caspase-mediated cleavage of occludin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47714", "l": "cis-3-hydroxy-D-proline => trans-3-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49295", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16050", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole => adenosylcob(III)alamin + GMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008764", "l": "UDP-N-acetylmuramoylalanine-D-glutamate ligase activity", "d": ["Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34166", "l": "hydroquinone + O2 <=> (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36390", "l": "carbamoyl adenylate + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40865", "l": "FADH2 + trans-2-heptadecenoyl-CoA => FAD + H(+) + heptadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014449", "l": "RHOG binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74730", "l": "Insulin degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787820", "l": "IL34 dimer binds CSF1R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.-", "l": "\"In ketonic substances\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420688", "l": "GABAB heterodimeric receptor binds GABA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65639", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62290", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22868", "l": "3-chloro-L-alanine + thioglycolate = chloride + H(+) + S-carboxymethyl-L-cysteine", "d": [], "t": []}, {"i": "EC:4.5.1.5", "l": "\"S-carboxymethylcysteine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12669", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.43", "l": "\"[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51545", "l": "D-ribulose => D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004903", "l": "growth hormone receptor activity", "d": ["Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57178", "l": "N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => L-arginyl-[protein] + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20159", "l": "an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+) => a polyvinyl alcohol + 2n Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59437", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61940", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose = 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592242", "l": "Expression of NRF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781899", "l": "USP13 binds SIAH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019766", "l": "IgA receptor activity", "d": ["Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399712", "l": "Activation of Ca permeable AMPA receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696323", "l": "CNRs bind CNR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37318", "l": "glycyl-L-glutamine + H2O <=> glycine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003949", "l": "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity", "d": ["Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74641", "l": "AMP(in) + CMP-N-acetyl-beta-neuraminate(out) => AMP(out) + CMP-N-acetyl-beta-neuraminate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21832", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.83", "l": "\"3,7-dimethylquercetin 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60713", "l": "(+)-artemisinic alcohol + NAD(+) => (+)-artemisinic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50322", "l": "1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029468", "l": "Conversion of PA into DAG by PAP-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58882", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0004691", "l": "cAMP-dependent protein kinase activity", "d": ["cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13107", "l": "glycerol + phosphate => glycerol 2-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43805", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018487", "l": "vanillate O-demethylase (anaerobic) activity", "d": ["Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848713", "l": "PTK6 binds BCAR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41113", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836270", "l": "TFAP2A binds TFAP2C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42922", "l": "H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1498) in 16S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669893", "l": "KIT binds type I TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71023", "l": "L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73660", "l": "ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) => ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832824", "l": "POU3F1 binds the SOX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16303", "l": "ADP-D-ribose + H(+) + nicotinamide => H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132088", "l": "Vitronectin prevents C9 polymerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46918", "l": "H(+) + juvenile hormone I carboxylate + methanol => H2O + juvenile hormone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033509", "l": "USP9X binds Ub:PEX5L (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36810", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA <=> 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990594", "l": "L-altrarate dehydratase activity", "d": ["Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O."], "t": []}, {"i": "RHEA:44028", "l": "L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.156", "l": "\"L-talarate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66603", "l": "2 dopamine + O2 <=> 2 dopamine quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31482", "l": "soyasapogenol A + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047326", "l": "inositol tetrakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53277", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10317", "l": "2-oxoglutarate + O2 + thymine => 5-hydroxymethyluracil + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050008", "l": "isopiperitenone delta-isomerase activity", "d": ["Catalysis of the reaction: isopiperitenone = piperitenone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28221", "l": "chloride + H(+) + H2O2 <=> H2O + hypochlorous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34740", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36017", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68031", "l": "6,8-dihydroxypurine + H2O + O2 <=> H2O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833777", "l": "PKR binds activating host RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093327", "l": "EPHA binds TIAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25471", "l": "(2E,6E)-farnesyl diphosphate <=> beta-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22819", "l": "alpha-D-xylose <=> alpha-D-xylulofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.93", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0002054", "l": "nucleobase binding", "d": ["Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755304", "l": "MUL1 ubiquitinates UBXN7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50012", "l": "H(+) + NADPH + O2 + tert-butanol = 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.229", "l": "\"tert-butanol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173705", "l": "C5b binds C6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.36", "l": "\"sn-1 acyl-lipid omega-3 desaturase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0052742", "l": "phosphatidylinositol kinase activity", "d": ["Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450474", "l": "MK2 phosphorylates BRF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005250", "l": "A-type (transient outward) potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential."], "t": []}, {"i": "REACT:R-HSA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102385", "l": "patchoulol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = seychellene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693111", "l": "RHOF auto-activates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101020", "l": "estrogen 16-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018594", "l": "tert-butanol 2-monooxygenase activity", "d": ["Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71719", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) = H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54121", "l": "coelenterazine h + O2 => coelenterazine h dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654571", "l": "Activated FGFR1 binds FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13856", "l": "4-methylene-L-glutamate + ATP + NH4(+) <=> 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17839", "l": "2-carboxy-D-arabinitol + phosphate => 2-carboxy-D-arabinitol 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984671", "l": "Chromokinesins form dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804527", "l": "INTL1 binds bacterial glycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68552", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32351", "l": "3 S-adenosyl-L-methionine + tricetin = 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.169", "l": "\"tricetin 3',4',5'-O-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75494", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) <=> 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879909", "l": "Activation of STAT5a/b by JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2870221", "l": "E-selectin binds E-selectin ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473596", "l": "Collagen type I degradation by MMP15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051751", "l": "alpha-1,4-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198756", "l": "ERK1/2 phosphorylates MSK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75244", "l": "FASL binds FAS Receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56908", "l": "(7S)-O-acetylsalutaridinol = acetate + H(+) + thebaine", "d": [], "t": []}, {"i": "EC:4.2.99.24", "l": "\"thebaine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362416", "l": "Frataxin binds iron (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34814", "l": "NADP(+) + tetrahydrocurcumin <=> dihydrocurcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357445", "l": "PAK1-3 dimer disassociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37916", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34559", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) = 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.340", "l": "\"1-deoxy-11beta-hydroxypentalenate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549129", "l": "OCT1 transports organic cations into hepatic cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2545196", "l": "FN1 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353058", "l": "glucose 6-phosphate + H2O => glucose + phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19427", "l": "5-hydroxyimidazole-4-acetate + H2O + NAD(+) => H(+) + imidazole-4-acetate + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981926", "l": "RAC1 and CDC42 activate PAK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981926", "l": "RAC1 and CDC42 activate PAK3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160044", "l": "sulfate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + sulfate(out) = chloride(out) + sulfate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76209", "l": "3',5'-cyclic GMP(out) => 3',5'-cyclic GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110475", "l": "DAkt1-mediated phosphorylation inactivates DFOXO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15450", "l": "homogentisate + O2 => 4-maleylacetoacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40698", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol <=> 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322427", "l": "Beta-catenin recruits CBP/p300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16833", "l": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.9", "l": "\"glutathione peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54233", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68421", "l": "cis-(homo)3aconitate + H2O => (2R,3S)-iso(homo)3citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25654", "l": "(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44323", "l": "1-decanoylglycerol + H2O <=> decanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050699", "l": "WW domain binding", "d": ["Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19718", "l": "H(+) + L-phenylalanine => 2-phenylethylamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48590", "l": "2 lipoxin B4 => 2 H2O + 2 leukotriene A4 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54627", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA <=> 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.132", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.6", "l": "\"alanine carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047261", "l": "steroid N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20371", "l": "glycine betaine + H(+) + H2O2 => betaine aldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75930", "l": "cyclohexylamine + H2O + NAD(+) <=> cyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30802", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25008", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102740", "l": "theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity", "d": ["Catalysis of the reaction: theobromine + S-adenosyl-L-methionine = H+ + caffeine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620103", "l": "ALDH2 transforms GTN to NO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.81", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47962", "l": "L-histidyl-[protein] + phosphate => H2O + N(tele)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34135", "l": "cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090409", "l": "malonyl-CoA synthetase activity", "d": ["Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38793", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54090", "l": "2,4,5-trihydroxyphenylacetate + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45913", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007539", "l": "CHEK1 phosphorylates E2F6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3341294", "l": "Superoxide reduces cytochrome c (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029680", "l": "Caspase-7 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.772337719465526", "identifiers": [{"i": "GO:0016903", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.835725707519245", "identifiers": [{"i": "GO:0061630", "l": "ubiquitin protein ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58276", "l": "6 ATP = cyclic hexaadenylate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667914", "l": "ALK binds ligand midkine (MDK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19624", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006870", "l": "IL21 receptor STAT phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57701", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14626", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) => [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010647", "l": "ROBO3.1 binds AKAP5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835385", "l": "DUS2 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351849", "l": "Caspase-mediated cleavage of Etk (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22507", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351341", "l": "Exocytosis of Proactivator polypeptide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.292", "l": "\"(phenol)carboxyphthiodiolenone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102846", "l": "1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140769", "l": "factor VII -> factor VIIa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20821", "l": "choline sulfate + H2O => choline + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130504", "l": "Cleavage of lip22 to lip10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31080", "l": "3-hydroxyisovaleryl-CoA => 3-methyl-(2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56229", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061815", "l": "Met1-linked polyubiquitin deubiquitinase activity", "d": ["Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains."], "t": []}, {"i": "REACT:R-HSA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817471", "l": "DPPA3 binds histone H3K9me2 in chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57784", "l": "1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73092", "l": "AMP(out) + FMN(in) => AMP(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211983", "l": "CYP2J2 oxidises ARA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49348", "l": "2,2-dihydroxyspirilloxanthin = 2-oxospirilloxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449117", "l": "TXLNA (IL14) binds syntaxin1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59505", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) => [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56382", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201457", "l": "BMP2 binds to the receptor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161692", "l": "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75367", "l": "cytidine(in) = cytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954082", "l": "E2F6 binds the PRC1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75419", "l": "(R,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262921", "l": "Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20754", "l": "AH2 + 2 aquacob(III)alamin => A + 2 cob(II)alamin + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140443", "l": "mitochondrion-plasma membrane adaptor activity", "d": ["The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52929", "l": "3',3'-c-di-GMP + 2 H2O => 2 GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13661", "l": "H2O + N-formimidoyl-L-aspartate = N-formyl-L-aspartate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.5", "l": "\"formimidoylaspartate deiminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40480", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30572", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine => 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828726", "l": "P mRNA is translated into protein P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450466", "l": "AUF1:mRNA complex is destroyed (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213195", "l": "Formation of anchoring fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20727", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA <=> a (3E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56587", "l": "1,2-epoxypropane + H2O <=> propane-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24299", "l": "(S)-dihydroorotate + H2O <=> H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033520", "l": "TYSND1 cleaves TYSND1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33933", "l": "(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal => all-trans-zeaxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865320", "l": "CBFB binds RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66976", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.382", "l": "\"CDP-abequose:alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36694", "l": "octadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77682", "l": "a globoside MSGG (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a globoside DSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050520", "l": "phosphatidylcholine synthase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693540", "l": "MRN activates ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74659", "l": "N-acetyl-D-glucosamine + UTP = H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54334", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32562", "l": "(2E)-geranyl diphosphate <=> diphosphate + gamma-terpinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53759", "l": "allodeoxycholoyl-CoA + cholate <=> allodeoxycholate + choloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429101", "l": "HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686578", "l": "Activated ATM phosphorylates ABL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18253", "l": "(S)-malate + NADP(+) = CO2 + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34352", "l": "(2E)-geranial + H2O + NAD(+) => geranate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67300", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one = 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12805", "l": "(S)-canadine + S-adenosyl-L-methionine = (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795667", "l": "MDM2 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49368", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75913", "l": "a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57325", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1990825", "l": "sequence-specific mRNA binding", "d": ["Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48534", "l": "a ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate => a ganglioside GQ1c (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707856", "l": "PGRMC2:Hemes dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50367", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879724", "l": "Expression of PPARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62100", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76553", "l": "CoA + H(+) + N-acetyl-D-aspartate => acetyl-CoA + D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42481", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42864", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermine + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.126", "l": "\"norspermine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987007", "l": "p-STAT1 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67715", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75283", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39168", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56310", "l": "1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11481", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59485", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O => arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679028", "l": "JAK3 binds JAK3 inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981832", "l": "NMUR2 binds neuromedin-S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11930", "l": "H(+) + H2O + hydrazine => hydroxylamine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60681", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) => (+)-artemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62341", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-malbrancheamide C + FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018867", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52180", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990003", "l": "IDP phosphatase activity", "d": ["Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73177", "l": "ADP(out) + FMN(in) => ADP(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5622134", "l": "CRABP1 binds atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74289", "l": "an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621002", "l": "HOXB1 activates HOXB2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625482", "l": "PTK2 binds activated EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849055", "l": "PTK6 binds ARHGAP35 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112385", "l": "Addition of nucleotides leads to transcript elongation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37092", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932765", "l": "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351208", "l": "Spermidine  => N-acetylated spermidine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50373", "l": "an N-acylsphingoid base 1-phosphate(in) => an N-acylsphingoid base 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000327", "l": "PLK1 phosphorylates BORA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10863", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112385", "l": "Addition of nucleotides leads to transcript elongation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757954", "l": "N4BP1 binds IKBKG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847534", "l": "RAB43 hydrolyses GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74982", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) <=> (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48942", "l": "2 an L-alpha-amino acid => an L-aminoacyl-L-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042011", "l": "interleukin-16 binding", "d": ["Binding to interleukin-16."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676599", "l": "sBAFF trimer binds BAFFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192912", "l": "NP binds vRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031863", "l": "prostaglandin D2 receptor binding", "d": ["Binding to a prostaglandin D2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18285", "l": "an N-acyl-D-aspartate + H2O = a carboxylate + D-aspartate", "d": [], "t": []}, {"i": "EC:3.5.1.83", "l": "\"N-acyl-D-aspartate deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379994", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950721", "l": "Expression of Programmed cell death protein 4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18872", "l": "ATP + L-xylulose <=> ADP + H(+) + L-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60412", "l": "H2O + monoglucosyl-enterobactin = [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41068", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374919", "l": "Noradrenaline clearance from the synaptic cleft (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391933", "l": "EP3 receptor can bind PGE2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14901", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = casbene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.8", "l": "\"casbene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42768", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015702", "l": "Expression of IFN-induced genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39953", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40597", "l": "CoA + dodecanedioate + H(+) => dodecanedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008545", "l": "JUN kinase kinase activity", "d": ["Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase."], "t": []}, {"i": "REACT:R-HSA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418662", "l": "Src activation following P2Y purinoceptor activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43312", "l": "ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75316", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) => chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672164", "l": "GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73796", "l": "dimethylallyl diphosphate + neoechinulin A => diphosphate + isoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10567", "l": "H2O + oxaloacetate 4-methyl ester <=> H(+) + methanol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66945", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051287", "l": "NAD binding", "d": ["Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879942", "l": "The receptor is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651809", "l": "LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614460", "l": "Dimerization of procollagen type VI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33373", "l": "alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein] => alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009401", "l": "RUNX2 binds SMURF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72416", "l": "Li(+)(in) + Na(+)(out) => Li(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805740", "l": "SETD8 methylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14697", "l": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.216", "l": "\"farnesol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12624", "l": "H(+) + L-aspartate <=> CO2 + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984606", "l": "Kinesin-5 is a homotetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44779", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine <=> H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769011", "l": "NPAS4 binds GEM gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102141", "l": "[chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35231", "l": "rifampicin(in) = rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17537", "l": "(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.73", "l": "\"carnitinamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42778", "l": "H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine => adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098624", "l": "3'-phosphoadenylylselenate reductase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+."], "t": []}, {"i": "REACT:R-HSA-2408548", "l": "PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103066", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19047", "l": "(3R)-citramalate + CoA + H(+) => acetyl-CoA + H2O + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10059", "l": "(3S)-3-aminobutanoyl-CoA <=> (2E)-butenoyl-CoA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010295", "l": "(+)-abscisic acid 8'-hydroxylase activity", "d": ["Catalysis of the reaction: (+)-abscisate + H+ + NADPH + O2 = (+)-8'-hydroxyabscisate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66165", "l": "butanoyl-CoA + serotonin => CoA + H(+) + N-butanoylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25815", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21704", "l": "H2O + L-tyrosine = NH4(+) + phenol + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.99.2", "l": "\"tyrosine phenol-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65819", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68336", "l": "(R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690873", "l": "ACO1 binds 4Fe-4S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71614", "l": "(S)-malate(in) + malonate(out) <=> (S)-malate(out) + malonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12542", "l": "AMP + diphosphate + L-alanyl-tRNA(Ala) => ATP + L-alanine + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26304", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) <=> (S)-allantoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10912", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.1", "l": "\"pantoate--beta-alanine ligase (AMP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663258", "l": "NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25579", "l": "3 O2 + protoporphyrinogen IX <=> 3 H2O2 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18172", "l": "4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061522", "l": "1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875568", "l": "RAPGEF1 activates RAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26163", "l": "(S)-2,3-epoxysqualene <=> thalianol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53601", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29444", "l": "H(+)(in) + L-alanine(in) => H(+)(out) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693198", "l": "RHOD binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57185", "l": "L-cysteinyl-[protein] + methylglyoxal => S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645481", "l": "TIFA oligomerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12004", "l": "indoxyl + UDP-alpha-D-glucose = H(+) + indican + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.220", "l": "\"indoxyl-UDPG glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982637", "l": "Opsins binds G alpha-t (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70639", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12331", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate <=> [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73425", "l": "L-asparagine(in) => L-asparagine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39380", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835328", "l": "NPM binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73806", "l": "AIR + CO2 => CAIR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20264", "l": "3,5,7-trioxododecanoyl-CoA <=> CO2 + CoA + olivetol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49449", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O => alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099579", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "d": ["A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49631", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102045", "l": "3-chlorobenzoate-3,4-oxygenase activity", "d": ["Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176298", "l": "Activation of claspin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.12", "l": "\"dihydrobenzophenanthridine oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14426", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299620", "l": "Collagen XI cross-links with collagen II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008867", "l": "galactarate dehydratase activity", "d": ["Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.117", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58509", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O => (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13456", "l": "3'-phosphoadenylyl sulfate + quercetin <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16387", "l": "CO2 + H2O + hydroquinone + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419011", "l": "Transhomodimerization of Nectins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33010", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55889", "l": "[aequorin]--dioxetanone => [excited state blue fluorescent protein] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141423", "l": "Binding of the MCC complex to the APC/C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046353", "l": "aminoglycoside 3-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51078", "l": "2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57851", "l": "2-oxoglutarate + O2 + scopoletin <=> CO2 + fraxetin + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852324", "l": "GTSE1 binds PLK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66894", "l": "10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40896", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65874", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => 1,17beta-dihydroxyandrostan-3-one + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56622", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37320", "l": "ATP + glycyl-L-methionine(out) + H2O => ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17748", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14870", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218811", "l": "DOCK180:ELMO binds CRK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52649", "l": "H2O + L-arabino-1,4-lactone 5-phosphate => 5-phospho-L-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190263", "l": "FGFR3b binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65636", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.111", "l": "\"mycocerosate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866269", "l": "ARRB bind GPCRs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38118", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol <=> 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451377", "l": "Interaction of IQGAP1 with nephrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19339", "l": "2 H(+) + hyponitrous acid + 2 NADH => 2 hydroxylamine + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73460", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57292", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63941", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30115", "l": "decanoyl-[ACP] + H2O = decanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39354", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43347", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13930", "l": "agmatine + H2O => putrescine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62265", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) => hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199299", "l": "AKT phosphorylates FOXO transcription factors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74569", "l": "L-glutamate(out) + N-acetyl-L-cysteine(in) => L-glutamate(in) + N-acetyl-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75891", "l": "Abortive Initiation After Second Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28463", "l": "pyridoxal(in) => pyridoxal(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5227009", "l": "ABCF1 binds EIF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68716", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50366", "l": "(S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14888", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] <=> ADP-D-ribose + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52271", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine <=> (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62664", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine = deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70842", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) <=> L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73902", "l": "ATP + cadaverine + L-glutamate <=> ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19880", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30764", "l": "H2O + L-valine + NAD(+) => 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65647", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51342", "l": "10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54423", "l": "3',3'-c-di-AMP + H2O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.52", "l": "\"trimerelysin I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55118", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+) => 5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53002", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69243", "l": "glucoraphanin + H2O <=> (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374909", "l": "Catabolism of Noradrenaline (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36651", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine = H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.284", "l": "\"8-demethylnovobiocic acid C(8)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47465", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59304", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin = adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47713", "l": "trans-3-hydroxy-L-proline => cis-3-hydroxy-D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34031", "l": "2'-N-acetylparomamine + H2O = acetate + paromamine", "d": [], "t": []}, {"i": "EC:3.5.1.112", "l": "\"2'-N-acetylparomamine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21406", "l": "chlorite => chloride + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27930", "l": "(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.36", "l": "\"4-phosphopantoate--beta-alanine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19877", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.67", "l": "\"1-phosphatidylinositol 4-kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43844", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 = (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20259", "l": "3-methyleneoxindole + H(+) + NADPH => 3-methyloxindole + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54101", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.48", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76957", "l": "2-methylbutanal + H(+) + NADH + NH4(+) => 2-methylbutanamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61527", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65953", "l": "2 a quinone + H(+) + NADH => 2 a 1,4-benzosemiquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530584", "l": "CREM (CREMP) binds to surface-bound C3b or C4b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46013", "l": "(S)-malate + a quinone => a quinol + oxaloacetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51513", "l": "H2O + oxamate => NH4(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0004180", "l": "carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22233", "l": "H(+) + NADPH + presqualene diphosphate => diphosphate + NADP(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65580", "l": "H2O + TTP = H(+) + phosphate + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299318", "l": "Activation of TASK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102090", "l": "adrenaline O-methyltransferase activity", "d": ["Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine = metanephrine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52227", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 <=> 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640368", "l": "Addition of Tegument to HCMV Nucleocapsid C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4647594", "l": "SAHF formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75525", "l": "CoA + H(+) + N-acetyl-S-methyl-L-cysteine => acetyl-CoA + S-methyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34053", "l": "6'''-deamino-6'''-hydroxyneomycin C + acetate => 2'''-acetyl-6'''-hydroxyneomycin C + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13059", "l": "an N-acylneuraminate + phosphate => an N-acylneuraminate 9-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53253", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427394", "l": "Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31366", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59201", "l": "ATP + docosanoate + H(+) => diphosphate + docosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40623", "l": "H2O + tritetradecanoylglycerol = 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24728", "l": "H(+) + indolmycin + S-adenosyl-L-homocysteine => N-demethylindolmycin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74828", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) => UDP-alpha-D-galacturonate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49871", "l": "(+)-dehydrodiconiferyl acid + a quinone <=> (+)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25290", "l": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36376", "l": "ATP + carbamoyl phosphate + H2O => carbamoyl adenylate + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21627", "l": "FMNH2 + NADP(+) <=> FMN + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74263", "l": "n H(+)(out) + spermine(in) = n H(+)(in) + spermine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15203", "l": "6-methoxymellein + H(+) + S-adenosyl-L-homocysteine => 6-hydroxymellein + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047441", "l": "5-dehydro-2-deoxyphosphogluconate aldolase activity", "d": ["Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801166", "l": "TP53 binds the STEAP3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58136", "l": "acetate + ATP + H(+) = acetyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75792", "l": "(S)-lactate(out) + Na(+)(out) => (S)-lactate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36978", "l": "AMP + phosphate <=> adenine + alpha-D-ribose 1,5-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9834821", "l": "p-PRKRA dimer binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177284", "l": "PKA phosphorylates PDE4B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39022", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733330", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17822", "l": "hydrogen cyanide + L-cysteine => 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5622134", "l": "CRABP1 binds atRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75861", "l": "all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11945", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15642", "l": "H(+) + oxaloacetate => CO2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.3.-", "l": "\"Hydrolyzing S-glycosyl compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16207", "l": "N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22262", "l": "H(+) + triacetate => H2O + triacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56356", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63579", "l": "ecdysone 22-phosphate + H2O <=> ecdysone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75290", "l": "glyoxylate(in) + sulfate(out) <=> glyoxylate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709879", "l": "BIL scavenges O2.- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33781", "l": "6,6-kestotetraose + beta-D-glucose => 6-kestotriose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15977", "l": "(S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}, {"i": "EC:4.1.2.11", "l": "\"hydroxymandelonitrile lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54366", "l": "acetoin => 2 acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112429", "l": "Formation of FACT complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14638", "l": "3'-phosphoadenylyl sulfate + a thiol => adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0003909", "l": "DNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20388", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35380", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52643", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390909", "l": "HRH2 binds hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35876", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37463", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67948", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69732", "l": "CoA + phenylacetyl-AMP => AMP + H(+) + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49504", "l": "phosphinomethylmalate = phosphinomethylisomalate", "d": [], "t": []}, {"i": "EC:4.2.1.166", "l": "\"phosphinomethylmalate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38335", "l": "(20S)-ginsenoside Rb1 + 2 H2O = (20S)-ginsenoside Rg3 + 2 D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.192", "l": "\"ginsenoside Rb1 beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362465", "l": "GHBP binds GHR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66011", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54040", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.168", "l": "\"dolathalia-3,7,11-triene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46924", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.157", "l": "\"(R)-2-hydroxyisocaproyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23479", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60116", "l": "2-oxoglutarate + methylphosphonate + O2 = CO2 + hydroxymethylphosphonate + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.71", "l": "\"methylphosphonate hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592229", "l": "TFAM translocates from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031829", "l": "type 4 serotonin receptor binding", "d": ["Binding to a type 4 serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14635", "l": "ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869694", "l": "oxPL binds CD14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050014", "l": "ketotetrose-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74521", "l": "beta-D-Gal-(1<->1')-Cer + H(+) + sulfate => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975853", "l": "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54102", "l": "H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.337", "l": "\"reticuline N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296233", "l": "T2Rs bind bitter-tasting compounds (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19656", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23980", "l": "cyclomaltodextrin + H2O = linear maltodextrin", "d": [], "t": []}, {"i": "EC:3.2.1.54", "l": "\"cyclomaltodextrinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49472", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.58", "l": "\"hydroxyproline O-arabinosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10116", "l": "6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140926", "l": "L-kynurenine transmembrane transporter activity", "d": ["Enables the transfer of L-kynurenine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14100", "l": "3-phenylpyruvate + L-aspartate <=> L-phenylalanine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57180", "l": "L-lysyl-[protein] + methylglyoxal = N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013438", "l": "RHOD binds effectors at the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23159", "l": "(E)-(indol-3-yl)acetaldehyde oxime <=> (indol-3-yl)acetonitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070892", "l": "lipoteichoic acid immune receptor activity", "d": ["Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68335", "l": "(R)-4'-phosphopantothenate + H2O <=> (R)-pantothenate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749215", "l": "MCM8 binds CDC6 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218821", "l": "PDK1 phosphorylates PKC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839039", "l": "Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45198", "l": "5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+) => 5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.29", "l": "\"pyranose dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.135", "l": "\"glyceollin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10095", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50541", "l": "prostaglandin A2 => prostaglandin C2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20088", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909718", "l": "Formation of p-STAT1 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28908", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) => 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.21", "l": "\"DNA-3-methyladenine glycosylase II\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34115", "l": "carboxynorspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34041", "l": "6'-oxoparomamine + L-glutamate => 2-oxoglutarate + neamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45956", "l": "(9Z)-octadecenoyl-CoA(in) = (9Z)-octadecenoyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43366", "l": "beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP => L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204600", "l": "Basigin homodimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034526", "l": "2-methylnaphthalene hydroxylase activity", "d": ["Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015699", "l": "ISGF3 binds the ISRE promoter elements in IFN-stimulated genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62498", "l": "diphosphate + L-arginyl-AMP => ATP + H(+) + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37992", "l": "delta-tocopherol + S-adenosyl-L-methionine => beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11086", "l": "CO2 + L-xylulose => 3-dehydro-L-gulonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59172", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] = AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61246", "l": "H2O2 + indole-3-pyruvate + NH4(+) => H2O + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428752", "l": "Dissociation of the TP:Gq complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65327", "l": "acetyl-CoA + chrodrimanin A <=> chrodrimanin B + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977375", "l": "CR1 binds C3bBb/C4bC2a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22460", "l": "a 2,3-saturated acyl-CoA + NADP(+) = a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.8", "l": "\"acyl-CoA dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61302", "l": "acetaldehyde + dihydroxyacetone phosphate => 5-deoxy-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210282", "l": "Interaction of GPVI and FceRI gamma (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38381", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14719", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate => D-erythrose 4-phosphate + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912505", "l": "Synapsis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610752", "l": "GLI3R translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160126", "l": "pH-gated calcium channel activity", "d": ["A gated channel activity that enables the transmembrane transfer of a calcium ion by a channel that opens in response to a change in pH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58433", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) => (E)-4-oxonon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54130", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63086", "l": "FAD + H(+) + 2 H2O + ilicicolin A => chloride + FADH2 + ilicicolin B + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38609", "l": "nicotinate-adenine dinucleotide phosphate => 2'-phospho-cyclic ADP-ribose + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57407", "l": "NAD(+) + narcotine hemiacetal <=> H(+) + NADH + noscapine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21816", "l": "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110218", "l": "Cleavage of uracil by TDG glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74730", "l": "Insulin degradation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40665", "l": "2-aminoprop-2-enoate + H2O => L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33203", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928625", "l": "PAKs autophosphorylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603467", "l": "Activated protein C is released from PROCR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32810", "l": "thiosulfate(in) <=> thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466238", "l": "BGN binds Collagen types II, III (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395412", "l": "Phosphorylation of SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75238", "l": "L-fucono-1,5-lactone <=> L-fucono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65611", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851908", "l": "Activated MET binds GAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62877", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate => A + semiviriditoxin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51298", "l": "a quinol + L-methionyl-(R)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin => CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035100", "l": "ecdysone binding", "d": ["Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0002113", "l": "interleukin-33 binding", "d": ["Binding to interleukin-33."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070180", "l": "large ribosomal subunit rRNA binding", "d": ["Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167597", "l": "Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53073", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74636", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 => 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658430", "l": "NF1 is degraded by the proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981713", "l": "C4b binds to cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832841", "l": "Expression of SOX2 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56196", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20386", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015640", "l": "peptidoglycan peptide transmembrane transporter activity", "d": ["Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11337", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine => deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.31.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49553", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => H(+) + L-lysyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702583", "l": "crenolanib-resistant FLT3 mutants don't bind crenolanib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39334", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22613", "l": "(3S)-citramalyl-CoA => acetyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55063", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55267", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70945", "l": "L-isoleucine(out) => L-isoleucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20044", "l": "3-oxopropanoate + H2O + NADP(+) <=> 2 H(+) + malonate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877003", "l": "CBLL1 ubiqutinates the InlA-bound CDH1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852317", "l": "PLK1 phosphorylates GTSE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264622", "l": "Cho is acetylated to AcCho by CHAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9669854", "l": "KIT binds type II TKIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051718", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)."], "t": []}, {"i": "REACT:R-HSA-5334151", "l": "DNMT1 methylates cytosine in hemimethylated DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18434", "l": "cyclohexylamine + H2O + O2 => cyclohexanone + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19026", "l": "H2O + L-aspartate + O2 => H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.-.-", "l": "\"Acting on peptide bonds (peptidases)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46820", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047508", "l": "(R)-2-methylmalate dehydratase activity", "d": ["Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54467", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48772", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55554", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807585", "l": "BPI binds LPS on the bacterial surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67380", "l": "H2O + L-alanyl-L-cysteine = L-alanine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45279", "l": "12-phosphooxy-(9E)-octadecenoate + H2O <=> 12-hydroxy-(9E)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55932", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035650", "l": "AP-1 adaptor complex binding", "d": ["Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033488", "l": "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48158", "l": "a ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate => a ganglioside GQ1b (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621425", "l": "Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784436", "l": "An unknown carrier transports mitochondrial glyoxylate to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28368", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22543", "l": "5'-dehydroadenosine + H2O + O2 <=> 9-riburonosyladenine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615249", "l": "ARBs bind AGRT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52392", "l": "ATP + D-erythronate = 4-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.220", "l": "\"D-erythronate 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35825", "l": "7,8-dihydromethanopterin + H(+) + NADH => 5,6,7,8-tetrahydromethanopterin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018746", "l": "RHOQ binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687465", "l": "MRN complex binds RBBP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57448", "l": "ATP + D-tyrosine + tRNA(Tyr) = AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332356", "l": "CAMK2 binds MAP3K7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71354", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) <=> androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848395", "l": "IL18:IL18R1 binds IL18RAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754974", "l": "ADK phosphorylates RBV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016149", "l": "translation release factor activity, codon specific", "d": ["A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-434650", "l": "MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806629", "l": "Formation of tonofilament bundles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55324", "l": "11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665871", "l": "ADRM1 binds 26S proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10295", "l": "acetyl-CoA + D-glucosamine 6-phosphate <=> CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692785", "l": "p-S215 FOXO1 binds RAG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76014", "l": "(3R)-hydroxybutanoate tetramer + H2O <=> (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44969", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH => NADP(+) + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72727", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-glucuronate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27437", "l": "2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.17", "l": "\"glutathione amide-dependent peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44902", "l": "D-galactonate + H(+) => D-galactono-1,4-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47058", "l": "4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43545", "l": "ATP + L-glutamate + tyramine => ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43278", "l": "a ganglioside GalNAc-GD1a + H(+) + UDP => a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33730", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine <=> a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624798", "l": "LBR binds KPNB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061769", "l": "ribosylnicotinate kinase activity", "d": ["Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.247531668414297", "identifiers": [{"i": "GO:0140299", "l": "small molecule sensor activity", "d": ["Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65490", "l": "2',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110322", "l": "Formation of Pol zeta complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29567", "l": "2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44518", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18852", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73942", "l": "desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine <=> dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018721", "l": "trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity", "d": ["Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769370", "l": "WIF1 binds WNTs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9653514", "l": "USP17L2 deubiquitinates RCE1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23385", "l": "D-cellobiose => beta-D-glucosyl-(1->4)-D-mannopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71283", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) = chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36863", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987214", "l": "p-STAT3 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139918", "l": "Phosphorylation of BIM by JNK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54673", "l": "(+)-kolavenyl diphosphate + H2O => (+)-kolavelool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77461", "l": "(2S)-2-hydroxy-2-(thiophen-3-yl)acetonitrile => 3-formylthiophene + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.61", "l": "\"alpha-dystroglycan beta1,4-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761834", "l": "NFE2L2 binds the TKT gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052904", "l": "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64181", "l": "an N-(fatty acyl)-L-tryptophan + H2O => a fatty acid + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28480", "l": "galactarate(out) + H(+)(out) => galactarate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.46", "l": "\"gentamicin 2''-nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762343", "l": "PREDL:ALB dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66266", "l": "diphosphate + nonanoyl-AMP => ATP + H(+) + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706344", "l": "FLT3 phosphorylates GRB10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031778", "l": "type 2 melanin-concentrating hormone receptor binding", "d": ["Binding to a type 2 melanin-concentrating hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13006", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine => H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64727", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42518", "l": "H(+) + L-gulonate => H2O + L-gulono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371591", "l": "Trimerization of cytosolic HSF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12627", "l": "D-glucose + sinapoyl (S)-malate => (S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36012", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193668", "l": "p75NTR and RHOA-GDI interact (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52197", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051432", "l": "BH1 domain binding", "d": ["Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58669", "l": "3-deoxyfructose + NADP(+) => 3-deoxyglucosone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8960973", "l": "RLBP1:11cRAL dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694522", "l": "Inner coat assembly and cargo binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13361", "l": "CTP + H(+) + sn-glycerol 3-phosphate = CDP-glycerol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.39", "l": "\"glycerol-3-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703008", "l": "tamatinib-resistant FLT3 mutants don't bind tamatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103054", "l": "gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)", "d": ["Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate = gibberellin A15 + carbon dioxide + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60474", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44882", "l": "ADP + H(+) + O-phospho-L-threonyl-[receptor-protein] => ATP + L-threonyl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5220959", "l": "TDG excises 5-formylcytosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29311", "l": "FMNH2 + O2 + sulfoacetate = FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45808", "l": "galactarate = (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.158", "l": "\"galactarate dehydratase (D-threo-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963915", "l": "1,25(OH)2D binds VDR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193068", "l": "CYP17A1 17-hydroxylates PREG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72008", "l": "succinate(in) + urate(out) => succinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72362", "l": "glutarate(in) + succinate(out) <=> glutarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189488", "l": "UROS transforms HMB to URO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53869", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate => 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77713", "l": "Fe(II)-heme b-[protein] + 2 H(+) + nitrite => Fe(III)-heme b-[protein] + H2O + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871506", "l": "SORL1 transports APP(18-770) from endosome lumen to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707586", "l": "FeHM oxidises LDL,HDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193684", "l": "p62 recruits an atypical PKC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22529", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853405", "l": "TPX2 binds AURKA at centrosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74487", "l": "anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine = (-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26547", "l": "beta-alaninamide + H2O => beta-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36811", "l": "acetyl-CoA + GDP-alpha-D-perosamine = CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.227", "l": "\"GDP-perosamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42262", "l": "3-oxononanoyl-[ACP] + CO2 + CoA => H(+) + heptanoyl-CoA + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60163", "l": "ATP + H2O + vincristine(in) <=> ADP + H(+) + phosphate + vincristine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24812", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31479", "l": "soyasapogenol A + UDP-alpha-D-glucuronate = H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482770", "l": "Release of platelet secretory granule components (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30201", "l": "2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422320", "l": "Heterotrimeric G(s) complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49903", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 <=> H2O2 + phenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928617", "l": "EPHB2 binds KALRN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74347", "l": "O-acyl-(R)-carnitine(in) = O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32392", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76481", "l": "H2O2 + hydroxyhexadecanal => hexadecane-1,16-diol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17666", "l": "L-lysyl-[protein] + octanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72933", "l": "atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14035", "l": "1D-myo-inositol 1-phosphate + glycerol + H(+) => H2O + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692809", "l": "CDC42 binds effectors at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944250", "l": "Association of procollagen type XXV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40228", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 => A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050390", "l": "valine decarboxylase activity", "d": ["Catalysis of the reaction: L-valine + H+ = 2-methylpropanamine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114264", "l": "Translocation of activated BAX to the mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17908", "l": "(R)-glycerate + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209921", "l": "Monoiodinated tyrosine can be deiodinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749197", "l": "ORC1 binds to H4K20me2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373705", "l": "Caspase cleavage of DCC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30269", "l": "L-ascorbate + L-dehydroascorbate => 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357445", "l": "PAK1-3 dimer disassociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72958", "l": "2 Na(+)(out) + nicotinate(out) <=> 2 Na(+)(in) + nicotinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005500", "l": "juvenile hormone binding", "d": ["Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30452", "l": "(S)-2,3-epoxysqualene => isomultiflorenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13130", "l": "cis-4-coumarate + UDP-alpha-D-glucose => 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390597", "l": "Release Of ADP From Myosin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32954", "l": "sucrose <=> trehalulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23884", "l": "nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.1", "l": "\"nicotinamide N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.90", "l": "\"togavirin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52479", "l": "estrone + UDP-alpha-D-glucuronate <=> estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25687", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) => L-cysteinyl-tRNA(Cys) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75541", "l": "(2E)-decenoyl-[ACP] + AMP + diphosphate => (2E)-decenoate + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52185", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731141", "l": "Syndecan-1 binds fibronectin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195733", "l": "M2 protein synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41017", "l": "1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50603", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.855431920422888", "identifiers": [{"i": "GO:0004518", "l": "nuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102398", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610757", "l": "GLI2 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160148", "l": "tRNA pseudouridine(55) synthase activity", "d": ["Catalysis of the reaction: uridine(55) in tRNA = pseudouridine(55) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13514", "l": "(S)-dihydroorotate + NAD(+) => H(+) + NADH + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62411", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine <=> 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17028", "l": "NADP(+) + xylitol <=> H(+) + L-xylulose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56343", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18820", "l": "acetyl-CoA + malonate <=> acetate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52471", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622627", "l": "BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17100", "l": "3-phenylpyruvate <=> enol-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679266", "l": "Beclin-1 complex translocates to the ER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:1990188", "l": "euchromatin binding", "d": ["Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428273", "l": "SPHK1 phosphorylates sphingoid (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36987", "l": "CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162099", "l": "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853496", "l": "SCF:FBXL7 binds AURKA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69586", "l": "guanosine + IMP => GMP + inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49083", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 <=> dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114284", "l": "Release of Cytochrome c from mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19189", "l": "H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate = CO2 + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]", "d": [], "t": []}, {"i": "EC:1.2.4.1", "l": "\"pyruvate dehydrogenase (acetyl-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106073", "l": "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "d": ["Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37861", "l": "1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59239", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + isoelisabethatriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975633", "l": "atROL binds to RBP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76962", "l": "2-methylbutanamine + H2O + NADP(+) <=> 2-methylbutanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61808", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP = AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102825", "l": "quercetin 3-O-rhamnoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside = quercetin 3-O-rhamnoside-7-O-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961907", "l": "E2F1 binds the CDC45 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10945", "l": "H2O + psi-UMP => phosphate + pseudouridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65719", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 <=> an aldehyde + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903880", "l": "17alpha-hydroxyprogesterone binding", "d": ["Binding to 17alpha-hydroxyprogesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54857", "l": "H(+) + NADPH + O2 + octan-3-one => ethyl hexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51561", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine => (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912627", "l": "CBL ubiquitinates PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51132", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77417", "l": "(2S,3E)-2-hydroxypent-3-enenitrile => (2E)-but-2-enal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45180", "l": "2 (E)-4-coumaroyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": [], "t": []}, {"i": "EC:2.3.1.249", "l": "\"spermidine dicoumaroyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15241", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.105", "l": "\"taxane 10beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.775903698273282", "identifiers": [{"i": "GO:0140303", "l": "intramembrane lipid transporter activity", "d": ["Enables the transport of a lipid from a region of a membrane to a different region on the same membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32393", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2R,4R)-dihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58601", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76011", "l": "(3R)-hydroxybutanoate tetramer + H2O = (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49852", "l": "(3E)-octenoyl-CoA = (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57658", "l": "a ganglioside GT1balpha + CMP + H(+) => a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15595", "l": "amicoumacin A + phosphate => amicoumacin A 2-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061981", "l": "3-hydroxykynureninase activity", "d": ["Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine."], "t": []}, {"i": "RHEA:25143", "l": "3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74475", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-4'-methoxycyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61558", "l": "gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190256", "l": "FGFR1c binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21209", "l": "H2O + O-phospho-L-serine => L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43936", "l": "androst-5-ene-3,17-dione = androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736979", "l": "p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218820", "l": "Src kinases phosphorylate VAV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158313", "l": "factor XII -> factor XIIa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63926", "l": "ADP + H(+) + N(4)-acetylcytidine 5'-phosphate => ATP + N(4)-acetylcytidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53238", "l": "(24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810392", "l": "TMEM55B translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36104", "l": "anthranilate + S-adenosyl-L-methionine => O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419152", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728150", "l": "SLC5A2 binds gliflozins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64279", "l": "chrysophanol-9-anthrone + O2 <=> chrysophanol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55946", "l": "chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2-chloroethanol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977301", "l": "Histidine is decarboxylated to histamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40059", "l": "decanoyl-CoA + H2O = CoA + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44899", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55088", "l": "eburicol + S-adenosyl-L-methionine = (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36955", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA = (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35101", "l": "fusidate(out) + H(+)(in) => fusidate(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0009973", "l": "adenylyl-sulfate reductase activity", "d": ["Catalysis of the reaction: A + AMP + 2 H+ + sulfite = adenosine 5'-phosphosulfate + AH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050172", "l": "phenylalanine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39836", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380930", "l": "Phosphorylated AMPK binds AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858475", "l": "TNFSF9 binds TNFRSF9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67459", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005315", "l": "inorganic phosphate transmembrane transporter activity", "d": ["Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66689", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.50", "l": "\"human endogenous retrovirus K endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75724", "l": "(9Z,12Z)-octadecadienoate + H2O => (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55398", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine => (R)-carnitine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34151", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate", "d": [], "t": []}, {"i": "EC:2.6.1.101", "l": "\"L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30291", "l": "(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}, {"i": "EC:1.13.11.58", "l": "\"linoleate 9S-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432946", "l": "PARVB/Affixin interacts with alpha PIX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388829", "l": "SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55887", "l": "[aequorin] + 3 Ca(2+) <=> [aequorin]--dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3785768", "l": "MRN complex binds DNA double strand breaks (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193776", "l": "Efflux of 24-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134946", "l": "DDX41 ubiquitination by TRIM21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195304", "l": "Association of beta-catenin with the destruction complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72936", "l": "(S)-lactate(out) + 2 Na(+)(out) => (S)-lactate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0004347", "l": "glucose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424476", "l": "Activation of RAC1 by VAV2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14567", "l": "3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008452", "l": "RNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990610", "l": "acetolactate synthase regulator activity", "d": ["Binds to and modulates the activity of acetolactate synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29974", "l": "2'-deoxyinosine(in) + H(+)(in) <=> 2'-deoxyinosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51886", "l": "D-proline betaine => L-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045550", "l": "geranylgeranyl reductase activity", "d": ["Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725206", "l": "IgE binds FCERI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052622", "l": "ATP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34118", "l": "carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798743", "l": "Exocytosis of secretory granule membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28798", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990439", "l": "MAP kinase serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63267", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004775", "l": "succinate-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43671", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate <=> 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724685", "l": "IgE binds omalizumab (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156910", "l": "Formation of eEF1B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29109", "l": "NAD(+) + ubiquinol-8 => H(+) + NADH + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32380", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52822", "l": "CoA + O-succinyl-L-serine => L-serine + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139919", "l": "Translocation of BIM to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33788", "l": "3'-ketolactose + H2O => 3-keto-beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75323", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) = chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647593", "l": "EP400 binds CDKN1A promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382056", "l": "Crk binds to the active PDGF receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54910", "l": "(4E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2471621", "l": "Endostatin degradation by cathepsins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769383", "l": "CBY1 binds beta-catenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35898", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61462", "l": "a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41440", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.46", "l": "\"2-aminoethylphosphonate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74560", "l": "aldosterone => aldosterone hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34274", "l": "2-nitroimidazole + H2O <=> 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187332", "l": "Cytosolic CMs translocate to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983307", "l": "IL15 binds IL15RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44091", "l": "ATP + CoA + heptanoate <=> AMP + diphosphate + heptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59026", "l": "dihexadecanoylglycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31401", "l": "all-trans-4,4'-diapo-zeta-carotene + FADH2 => all-trans-4,4'-diapophytofluene + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357432", "l": "AXL binds SRC-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59214", "l": "AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12188", "l": "2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}, {"i": "EC:1.2.4.2", "l": "\"oxoglutarate dehydrogenase (succinyl-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047126", "l": "N5-(carboxyethyl)ornithine synthase activity", "d": ["Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H2O + NADP+ = L-ornithine + H+ + NADPH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611751", "l": "β1,2-agonists bind ADRB1,2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607753", "l": "CARD9 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70052", "l": "2-oxoadipate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832935", "l": "POU3F1 binds the OTX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592316", "l": "Initial activation of proMMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964280", "l": "Active Gq binds BTK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16006", "l": "galactarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299338", "l": "Activation of TRESK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25824", "l": "H2O + O2 + spermine = H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22528", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.159", "l": "\"flavonol-3-O-glucoside L-rhamnosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77372", "l": "[alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate => [alpha-N-acetylneuraminyl-(2->8)](n+1)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49603", "l": "ATP + CoA + octanedioate <=> AMP + diphosphate + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28910", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) <=> 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0000829", "l": "inositol heptakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578965", "l": "TNRC6A binds AGO2:miRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684052", "l": "PIAS4 SUMOylates MDC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36638", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785607", "l": "FANCM binds FAAP24 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42310", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13065", "l": "ATP + H2O = ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10511", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65609", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69251", "l": "H2O + sinigrin <=> (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39159", "l": "(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60702", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline => a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045303", "l": "diaminobutyrate-2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424485", "l": "Release of p-PLCG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16901", "l": "acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.178", "l": "\"diaminobutyrate acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072547", "l": "tricoumaroylspermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24123", "l": "H(+) + leukotriene E4 + NADPH + O2 <=> 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15734", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21216", "l": "ATP + D-ribose 5-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.18", "l": "\"phosphoribokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28161", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062182", "l": "all-trans retinoic acid 4-hydrolase activity", "d": ["Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:51492", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098625", "l": "methylselenol reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O."], "t": []}, {"i": "REACT:R-HSA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71151", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one = (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.-", "l": "\"Acting on other compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44865", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099618", "l": "UDP-glucuronic acid dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047909", "l": "galactolipid O-acyltransferase activity", "d": ["Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45596", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41925", "l": "(3R)-hydroxyoctadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41084", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614811", "l": "Transcriptional Activation of the HCMV Genome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56179", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O <=> 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42001", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => an isogloboside iGb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47283", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102795", "l": "1-naphthaldehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23210", "l": "(2E)-glutaconyl-CoA + acetate => acetyl-CoA + trans-glutaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944454", "l": "mTORC1 phosphorylates MAF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030559", "l": "rRNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32259", "l": "beta-D-fructose 1-phosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168136", "l": "NOTCH3 binds DLL4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42583", "l": "ATP + L-serine + tRNA(Sec) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40995", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029471", "l": "Hydrolysis of PC to PA by PLD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77532", "l": "hydrogen cyanide + nonanal => (2S)-2-hydroxydecanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785213", "l": "LIPC dimer binds heparin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432162", "l": "Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67849", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73919", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) = H2O + norlichexanthone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.105", "l": "\"monocyclic monoterpene ketone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876789", "l": "CARNMT1 methylates CARN to Anserine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050510", "l": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77306", "l": "N(omega),N(omega)-dimethyl-L-arginine + pyruvate <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912727", "l": "CBL binds VAV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673349", "l": "WNT5 binds FZD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17166", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140806", "l": "SERPINC1 binds SERPINC1 activators (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39036", "l": "an omega-hydroxy fatty acid + NAD(+) => an omega-oxo fatty acid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15995", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+) => anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71307", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) = chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0141051", "l": "histone H4K deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine + H2O = histone H4 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004484", "l": "mRNA guanylyltransferase activity", "d": ["Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49410", "l": "[(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->2)-beta-D-mannosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193997", "l": "CYP11B1 oxidises 11DCORT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0061650", "l": "ubiquitin-like protein conjugating enzyme activity", "d": ["Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57451", "l": "ATP + D-tyrosine + tRNA(Tyr) <=> AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419049", "l": "ROCK activation by RHO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.43", "l": "\"arogenate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214393", "l": "Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45105", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine => mitomycin A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809309", "l": "MTMR6 binds MTMR9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45733", "l": "D-ribulose 5-phosphate + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18780", "l": "an alkylmercury + H(+) <=> an alkane + Hg(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46001", "l": "adenosine + H(+) + tuberculosinyl diphosphate => 1-tuberculosinyladenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "51.008513579594286", "identifiers": [{"i": "GO:0046873", "l": "metal ion transmembrane transporter activity", "d": ["Enables the transfer of metal ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76812", "l": "(S)-methioninol + H2O + NAD(+) => 1-hydroxy-4-(methythio)butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42384", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) = 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41037", "l": "1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73467", "l": "beta-alanyl-dopamine + H2O = beta-alanine + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51975", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67095", "l": "ATP + docosanoate(in) + H2O <=> ADP + docosanoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39611", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11140", "l": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.4.2.8", "l": "\"phosphomannomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51957", "l": "(E)-2-methylpropanal oxime => (Z)-2-methylpropanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140759", "l": "histone H3K56 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39426", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28249", "l": "(R)-pantoate + ATP <=> (R)-4-phosphopantoate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33071", "l": "D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.124", "l": "\"2-deoxy-scyllo-inosose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0001070", "l": "RNA-binding transcription regulator activity", "d": ["A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444572", "l": "Zinc is an agonist of GPR39 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.10827943762402", "identifiers": [{"i": "GO:0048018", "l": "receptor ligand activity", "d": ["The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667761", "l": "KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800798", "l": "The PIDDosome binds CASP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16414", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11409", "l": "H(+) + H2O + riboflavin => lumichrome + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34016", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002466", "l": "Formation of allysine by LOX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210773", "l": "PDX1-dependent synthesis of NR5A2 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13962", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX => ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49434", "l": "choloyl-CoA + lithocholate => cholate + lithocholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70971", "l": "citrate <=> isocitrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614614", "l": "Cysteine is degraded to serine and H2S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24528", "l": "(R)-lactaldehyde + NAD(+) = H(+) + methylglyoxal + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.78", "l": "\"methylglyoxal reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800793", "l": "PIDD1 translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51435", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA <=> [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31794", "l": "H2O + tuberculosinyl diphosphate <=> (13S)-edaxadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626681", "l": "Recruitment of transition zone proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25956", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.24", "l": "\"3-dehydroquinate synthase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71701", "l": "H(+)(in) + L-phenylalanyl-L-leucine(in) => H(+)(out) + L-phenylalanyl-L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21724", "l": "a nitrile + 2 H2O = a carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73505", "l": "3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69314", "l": "benzyl thiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660192", "l": "VDR agonists bind VDR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964759", "l": "Alternative endo-mannosidase I route (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76407", "l": "H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline", "d": [], "t": []}, {"i": "EC:3.4.13.9", "l": "\"Xaa-Pro dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46329", "l": "L-threo-3-phenylserine => 3-phenylpyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12697", "l": "ATP + dGMP = ADP + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69540", "l": "GTP + streptomycin = 6-O-guanylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64489", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA => 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47917", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine => ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47290", "l": "7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25563", "l": "9alpha-copalyl diphosphate <=> 9beta-pimara-7,15-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53149", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202510", "l": "Activation of TAK1-TAB2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39783", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75897", "l": "CoA + thiomarinol C => holothin + marinoloyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928602", "l": "NGEF binds EPHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67479", "l": "dimethylallyl diphosphate + L-glutamate <=> diphosphate + prekainate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59685", "l": "D-maltohexaose + O2 => D-maltohexaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12256", "l": "L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70604", "l": "4-hydroxystyrene + H(+) + NADH => 4-ethylphenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33548", "l": "H2O + lanosteryl hexadecanoate => H(+) + hexadecanoate + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75999", "l": "glutarate(in) + kynurenate(out) = glutarate(out) + kynurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11010", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033801", "l": "vitexin 2''-O-rhamnoside 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33805", "l": "2 H(+) + L-histidine + NADH => H2O + L-histidinal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14450", "l": "chlorophyllide a + NADP(+) => 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52168", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434650", "l": "MATEs mediate extrusion of xenobiotics (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24115", "l": "2 glutathione + O2 <=> glutathione disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11162", "l": "L-aspartate 4-semialdehyde + L-glutamate => 2-oxoglutarate + L-2,4-diaminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20492", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50026", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine => dodecanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30982", "l": "A + all-trans-lycopene <=> AH2 + all-trans-3,4-didehydrolycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002057", "l": "guanine binding", "d": ["Binding to guanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16270", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) => 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624954", "l": "INPP5E translocates to the primary cilium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26014", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate = 3-dehydroquinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0015422", "l": "ABC-type oligosaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050368", "l": "tyrosine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43137", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24949", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59756", "l": "L-arginine + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.381", "l": "\"arginine N(omega)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36586", "l": "dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2317332", "l": "PIP3 recruits AKT to the membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48949", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57126", "l": "2-hydroxy-5-oxoproline => 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14692", "l": "4-chlorophenylacetate + NADH + O2 <=> 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39387", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA = (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862380", "l": "HSD17B13 binds lipid droplets (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106614", "l": "Duplex miRNA is loaded into Argonaute (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48218", "l": "(2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050587", "l": "chlorite O2-lyase activity", "d": ["Catalysis of the reaction: chloride + O2 = chlorite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57440", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] = 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33454", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37738", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12302", "l": "3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine + uridine(47) in tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20211", "l": "ADP + H(+) + xylitol 5-phosphate => ATP + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22947", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110172", "l": "MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63566", "l": "apelin-12 + L-phenylalanine => apelin-13 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52376", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) = (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16845", "l": "acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050733", "l": "RS domain binding", "d": ["Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22057", "l": "hexadecan-1-ol + NAD(+) => H(+) + hexadecanal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687107", "l": "MAPK4,6 translocate to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44238", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874082", "l": "MET phosphorylates PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43174", "l": "N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine => guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36883", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49993", "l": "H(+) + NADH + O2 + propane => H2O + NAD(+) + propan-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9769235", "l": "MAGED1 binds NPAS4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60947", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17304", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14139", "l": "6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0050780", "l": "dopamine receptor binding", "d": ["Binding to a dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40932", "l": "2-oxoglutarate + L-ornithine + O2 => (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016538", "l": "cyclin-dependent protein serine/threonine kinase regulator activity", "d": ["Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins."], "t": []}, {"i": "REACT:R-HSA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12791", "l": "an aldose + H(+) + NADPH => an alditol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39191", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH = docosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10179", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42592", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042878", "l": "D-glucarate transmembrane transporter activity", "d": ["Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47722", "l": "NH4(+) + xanthine => H(+) + H2O + isoguanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047966", "l": "glycosulfatase activity", "d": ["Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50311", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392749", "l": "Transport of L1 into endosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102167", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] = N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27317", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 <=> 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-535717", "l": "Binding of calnexin/calreticulin to the unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109858", "l": "MAP2K2 binds MAPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36989", "l": "alpha-D-ribose 1,5-bisphosphate + cytosine => CMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52150", "l": "an aliphatic (Z)-desulfo-glucosinolate + UDP => a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46611", "l": "ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679044", "l": "FKBP1A binds sirolimus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33861", "l": "H2O + versicolorin B => (2S-3S)-versiconal hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34007", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine = 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28886", "l": "H(+)(in) + L-threonine(in) <=> H(+)(out) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57589", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71815", "l": "3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66460", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = 14betaH-scalarane-17alpha-19-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70642", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013147", "l": "RAC1 GDIs block activation of RAC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77338", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70937", "l": "L-lysine(out) => L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858500", "l": "CLEC10A binds Tn-MUC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353526", "l": "Repair of ~27-30 bp long patch by DNA Pol Epsilon (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694409", "l": "Nucleotide exchange on RAB1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866941", "l": "MID1IP1 binds THRSP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76388", "l": "ATP + L-glutamate + N(6)-hydroxy-L-lysine => 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39285", "l": "a long-chain fatty acid(in) => a long-chain fatty acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16929", "l": "2 benzoyl-CoA + L-ornithine = 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": [], "t": []}, {"i": "EC:2.3.1.127", "l": "\"ornithine N-benzoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45975", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052679", "l": "terpentetriene synthase activity", "d": ["Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938853", "l": "CDK6 binds RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948775", "l": "MKRN1 polyubiquitinates PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748996", "l": "GST dimers cleave AZA to 6MP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047969", "l": "glyoxylate oxidase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + O2 = H2O2 + H+ + oxalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112727", "l": "Serine phosphorylation of STATs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74888", "l": "2',3'-cGAMP(in) + ATP + H2O => 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56252", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997237", "l": "SH2B proteins bind JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40370", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173542", "l": "SMURF2 ubiquitinates SMAD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15620", "l": "Fe(3+) + Fe(II)-[cytochrome c] <=> Fe(2+) + Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47371", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26417", "l": "a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43138", "l": "4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine => guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102476", "l": "pinocembrin 2-hydroxylase activity", "d": ["Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ = 2,5,7-trihydroxyflavanone + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665871", "l": "ADRM1 binds 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982807", "l": "JAK2 phosphorylation of GHR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209536", "l": "IkB is ubiquitinated and degraded (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195926", "l": "Association with M1 at cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28538", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54486", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28755", "l": "a ubiquinone + sn-glycerol 3-phosphate = a ubiquinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71371", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25883", "l": "2 L-dopa + O2 <=> 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58072", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH = a jasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28046", "l": "phosphate + propanoyl-CoA = CoA + propanoyl phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.222", "l": "\"phosphate propanoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16426", "l": "formaldehyde + H2O + NAD(+) => formate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39649", "l": "5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+) => AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17257", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": [], "t": []}, {"i": "EC:1.14.14.104", "l": "\"vinorine hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59306", "l": "adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly L-luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008863", "l": "formate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: formate + NAD+ = CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102777", "l": "caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696547", "l": "STAMBPL1 is a deubiquitinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28540", "l": "ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805785", "l": "AKT phosphorylates PHF20 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13430", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) => 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858475", "l": "ppDVL recruits RAC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24108", "l": "H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine", "d": [], "t": []}, {"i": "EC:3.5.1.36", "l": "\"N-methyl-2-oxoglutaramate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.62", "l": "\"beta-tubulin-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47459", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) <=> 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082356", "l": "HSF1-mediated gene expression (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102918", "l": "(R)-reticuline 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine = (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69659", "l": "H2O + kaempferol 3-O-beta-D-glucoside = beta-D-glucose + kaempferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76644", "l": "xanthine(out) => xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37857", "l": "1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47656", "l": "acetyl-CoA + L-methionine sulfone = CoA + H(+) + N-acetyl-L-methionine sulfone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16160", "l": "2 Fe(III)-[leghemoglobin] + NADPH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17512", "l": "H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003836", "l": "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49253", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] => D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051108", "l": "carnitine-CoA ligase activity", "d": ["Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848864", "l": "PTK6 binds ARAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64673", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol => butyl 2-(methylsulfanyl)acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62109", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874083", "l": "p-Y397-PTK2 binds SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698931", "l": "C Nucleocapsid Assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879910", "l": "JAK2 is phosphorylated, activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49154", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047718", "l": "indanol dehydrogenase activity", "d": ["Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944216", "l": "Association of procollagen type XV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791016", "l": "SFTPB binds itself (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34891", "l": "selenite(in) = selenite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661230", "l": "MT1A binds arsenic (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55647", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] <=> ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602966", "l": "Defective FMO3 does not N-oxidise TMA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619355", "l": "CaMKK autophosphorylates in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197588", "l": "NICD2 binds RBPJ and MAML in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650165", "l": "ASIC trimers bind H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70395", "l": "3-oxosphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55953", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070320", "l": "inward rectifier potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31182", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) <=> 3-oxododecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785722", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34522", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine <=> [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73718", "l": "ATP(in) + dATP(out) <=> ATP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051379", "l": "epinephrine binding", "d": ["Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61618", "l": "formaldehyde + H2O + N-methyl-L-proline + NAD(+) => H(+) + L-proline betaine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198983", "l": "NKG2D homodimer interacting with ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52483", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615249", "l": "ARBs bind AGRT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22359", "l": "diphosphate + oxaloacetate <=> CO2 + phosphate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29734", "l": "beta-maltose(in) <=> beta-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.124", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62332", "l": "ADP + ATP = adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005300", "l": "high-affinity tryptophan transmembrane transporter activity", "d": ["Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24906", "l": "L-tyrosine = (E)-4-coumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61865", "l": "AH2 + dehydroprobetaenone I => A + probetaenone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015473", "l": "fimbrial usher porin activity", "d": ["A porin that acts in the assembly of fimbria together with fimbrial chaperone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645598", "l": "RRAGC,D hydrolyzes GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030769", "l": "macrocin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H+ + tylosin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30180", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] => 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050077", "l": "maleylpyruvate isomerase activity", "d": ["Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9660192", "l": "VDR agonists bind VDR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700171", "l": "Active ALK phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849094", "l": "ARHGAP35 binds RASA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26316", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51471", "l": "(R)-lactate + a quinone <=> a quinol + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847880", "l": "CYTH proteins bind ARF1:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76280", "l": "hypoxanthine(out) + Na(+)(out) => hypoxanthine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28927", "l": "3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.57", "l": "\"gallate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55976", "l": "glutathione + thiosulfate = H(+) + S-sulfanylglutathione + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015244", "l": "fluconazole transmembrane transporter activity", "d": ["Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0050309", "l": "sugar-terminal-phosphatase activity", "d": ["Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate."], "t": []}, {"i": "EC:3.1.3.58", "l": "\"sugar-terminal-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32816", "l": "Hg(2+)(in) => Hg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12625", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose = D-glucose + sinapoyl (S)-malate", "d": [], "t": []}, {"i": "EC:2.3.1.92", "l": "\"sinapoylglucose--malate O-sinapoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50798", "l": "prostaglandin A2-S-(R)-glutathione => glutathione + prostaglandin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668545", "l": "NIK autophosphorylates on T559 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0038181", "l": "bile acid receptor activity", "d": ["Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873927", "l": "Release of STAT1 dimer from active receptor unit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68650", "l": "H(+) + hydrogen sulfide + L-lanthionine => 2 L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17142", "l": "glycine + oxaloacetate => glyoxylate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848864", "l": "PTK6 binds ARAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029460", "l": "PAK1 phosphorylates LIMK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61998", "l": "CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein] => L-lysyl-[protein] + lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794475", "l": "Cipro:ALB dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18337", "l": "D-ribose 5-phosphate + uracil = H2O + psi-UMP", "d": [], "t": []}, {"i": "EC:4.2.1.70", "l": "\"pseudouridylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42063", "l": "11-cis-retinol + NAD(+) <=> 11-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60765", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone => cinerin II + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38030", "l": "(E)-caffeate + hydrocaffeoyl-CoA <=> (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46389", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54190", "l": "acetate + L-phenylalanine => H2O + N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24848", "l": "3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.118", "l": "\"3-dehydroshikimate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11642", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH => a (2R,3R)-flavan-3-ol + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48217", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75388", "l": "H2O + queuosine 5'-phosphate => D-ribose 5-phosphate + queuine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43876", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA = 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695964", "l": "ABHD14B hydrolyses PNPB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102723", "l": "UDP-glucose:curcumin glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36134", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22122", "l": "GDP + phosphate + succinyl-CoA => CoA + GTP + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65038", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37957", "l": "(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030766", "l": "11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380930", "l": "Phosphorylated AMPK binds AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65107", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] <=> aculene B + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726580", "l": "PGR binds PGR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35756", "l": "NAD(+) + UDP-alpha-D-glucose => H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62226", "l": "(E)-ascladiol + NADP(+) => H(+) + NADPH + neopatulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.218", "l": "\"phenylpropanoylacetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45868", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11559", "l": "(S)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380586", "l": "loading of Serotonin in synaptic vesicles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693536", "l": "ATM phosphorylates MDC1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65536", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theacrine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42585", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58132", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932020", "l": "GPAM gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093327", "l": "EPHA binds TIAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13798", "l": "a dolichyl phosphate + H2O => di-trans,poly-cis-dolichol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662595", "l": "MT1E binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004941", "l": "beta2-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705926", "l": "AR binds AR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57259", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP <=> GTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008426", "l": "protein kinase C inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047855", "l": "dihydrobunolol dehydrogenase activity", "d": ["Catalysis of the reaction: dihydrobunolol + NADP+ = bunolol + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32891", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 = alpha-pinene oxide + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.155", "l": "\"alpha-pinene monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51991", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> 18S-resolvin E1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63414", "l": "2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O => 2,4,6-trichlorophenol + FADH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35021", "l": "L-threonine(out) => L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11374", "l": "AMP + diphosphate + H(+) + L-asparagine => ATP + L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16430", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46324", "l": "3-oxochol-4-en-22-oyl-CoA + A = 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400434", "l": "FFAR1 binds fatty acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44127", "l": "hexadecanoyl-CoA + tetradecan-1-ol <=> CoA + tetradecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58035", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534378", "l": "Hv1 Mediated H+ Permeability (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34973", "l": "Fe(3+)(out) => Fe(3+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75189", "l": "2,5-dihydroxybenzoate + CoA + H(+) => 2,5-dihydroxybenzoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858252", "l": "HDLBP binds HDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22850", "l": "3-oxooctanedioyl-CoA + H(+) + NADH => (3S)-hydroxyoctanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18042", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60075", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432361", "l": "Cytosolic PER is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619756", "l": "NR1H2 binds ABCA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20573", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694377", "l": "pp1a cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070225", "l": "sulfide dehydrogenase activity", "d": ["Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23978", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate => a 3'-end 3'-phospho-ribonucleotide-RNA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983144", "l": "Transport of Antigen peptide in to ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111238", "l": "Formation of ADAR2  homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390649", "l": "CHRM1,3,5 bind acetylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449818", "l": "IL13 binds IL13RA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799332", "l": "ATR phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030233", "l": "deoxynucleotide transmembrane transporter activity", "d": ["Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018768", "l": "RHOU auto-activates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34473", "l": "acryloyl-CoA + H(+) + NADH => NAD(+) + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805285", "l": "PLK3 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944236", "l": "Association of procollagen type XIV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53511", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione <=> (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.341", "l": "\"vanillate/3-O-methylgallate O-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791186", "l": "Expression of ZBTB17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40573", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23418", "l": "(2R)-3-sulfolactate + phosphate => (2R)-O-phospho-3-sulfolactate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629497", "l": "NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052677", "l": "D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56766", "l": "12-epi-fischerindole G + CO2 + H2O + succinate => 12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102791", "l": "sulfuretin synthase activity", "d": ["Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129362", "l": "Fibrillin microfibril assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69502", "l": "ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide => L-arginyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26050", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55715", "l": "3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46409", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34314", "l": "4-nitrocatechol + NADH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093329", "l": "EFNBs bind SDCBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41143", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50128", "l": "NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61429", "l": "cis-trans-nepetalactol + NAD(+) => cis-trans-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26444", "l": "a ubiquinol + acetaldehyde => a ubiquinone + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730521", "l": "SARS-CoV-2 3a induces potassium efflux (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13932", "l": "agmatine + H2O <=> putrescine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20229", "l": "2,3-dihydroxybenzoate + ATP + H(+) = 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004322", "l": "ferroxidase activity", "d": ["Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798304", "l": "TP53 binds the E2F7 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13583", "l": "H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP => N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.104", "l": "\"enoyl-[acyl-carrier-protein] reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173636", "l": "Formation of classic pathway C5 convertase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604731", "l": "Autocatalytic activation of MMP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150025", "l": "oxidised low-density lipoprotein particle receptor activity", "d": ["Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103004", "l": "9,10-epoxystearate hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH = 9,10-epoxy-18-hydroxystearate + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45089", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043546", "l": "molybdopterin cofactor binding", "d": ["Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58249", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O => ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004813", "l": "alanine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23234", "l": "4 Fe(II)-[cytochrome c] + 4 H(+) + N2 => 4 Fe(III)-[cytochrome c] + hydrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43469", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418925", "l": "ADORA2A,B bind Ade-Rib (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450031", "l": "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008914", "l": "leucyl-tRNA--protein transferase activity", "d": ["Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196773", "l": "COASY phosphorylates DP-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44930", "l": "(R)-trihomocitrate + CoA + H(+) => 2-oxoheptanedioate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047832", "l": "D-pinitol dehydrogenase activity", "d": ["Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39693", "l": "(11Z)-octadecenoyl-CoA + NADP(+) => (2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15376", "l": "columbamine + S-adenosyl-L-methionine <=> H(+) + palmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047870", "l": "discadenine synthase activity", "d": ["Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018798", "l": "RHOV binds GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202291", "l": "Activation of Lck (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35861", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.187", "l": "\"GDP-4-dehydro-D-rhamnose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0016842", "l": "amidine-lyase activity", "d": ["Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate."], "t": []}, {"i": "EC:4.3.2.-", "l": "\"Lyases acting on amides, amidines, etc\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46233", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67831", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a lipid A disaccharide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46260", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71514", "l": "phylloquinone(out) <=> phylloquinone(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61148", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64597", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53044", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35793", "l": "H(+) + kanamycin X + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32660", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) => (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25391", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) = cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.77", "l": "\"3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849428", "l": "PTPN1 binds PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858346", "l": "AMHR2 binds AMH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662608", "l": "MT2A binds cadmium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683765", "l": "Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14556", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate <=> 2-oxoglutarate + cephalosporin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080013", "l": "(E,E)-geranyllinalool synthase activity", "d": ["Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634861", "l": "NPAS4 binds ARNT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59468", "l": "an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74716", "l": "Insulin binds the insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18506", "l": "L-lysine + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018460", "l": "cyclohexanol dehydrogenase activity", "d": ["Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692749", "l": "CDC14A,B bind MAPK6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "47.698866582107286", "identifiers": [{"i": "GO:0016491", "l": "oxidoreductase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002401", "l": "Association of procollagen type XVIII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54511", "l": "all-trans-heptaprenyl diphosphate <=> beta-heptaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295613", "l": "SPRY2 binds GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15551", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689000", "l": "AADAC deacetylates PHEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61482", "l": "an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+) => a sphingoid base + a very long-chain fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77407", "l": "2,2-dimethylpropanal + hydrogen cyanide = (2S)-2-hydroxy-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69643", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20290", "l": "acetyl-CoA + H2O => acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35410", "l": "H2O + medicarpin <=> 4'-methoxyisoflavan-2',4,7-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-555065", "l": "Formation of clathrin coated vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380316", "l": "Association of NuMA with microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68419", "l": "cis-(homo)2aconitate + H2O <=> (2R,3S)-iso(homo)2citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785898", "l": "IL4R binds JAK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28144", "l": "streptothricin D acid => H2O + streptothricin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015089", "l": "high-affinity copper ion transmembrane transporter activity", "d": ["Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44011", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) <=> a 2-methyl fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633460", "l": "MDM2 binds TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853792", "l": "RET tyrosine phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64234", "l": "atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O => 8 H(+) + holo-[ACP] + 8 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10158", "l": "12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58005", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382054", "l": "PDGF binds to extracellular matrix proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73045", "l": "creatine(out) => creatine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38430", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23560", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668545", "l": "NIK autophosphorylates on T559 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22624", "l": "(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.39", "l": "\"4-hydroxy-2-oxovalerate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011598", "l": "DOCKs bind to RhoGEFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42660", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}, {"i": "EC:1.1.1.374", "l": "\"UDP-N-acetylglucosamine 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036052", "l": "Defective NAGLU does not hydrolyse heparan chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31349", "l": "2-cis-(+)-abscisate + beta-D-glucose + H(+) => (+)-abscisic acid D-glucopyranosyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58172", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.200", "l": "\"beta-pinacene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102714", "l": "gibberellin A12,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A14 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0035035", "l": "histone acetyltransferase binding", "d": ["Binding to an histone acetyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47019", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O <=> [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47603", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM4 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140311", "l": "protein sequestering activity", "d": ["Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176452", "l": "Degradation of ubiquitinated SMAD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37419", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69578", "l": "CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] => 2-oxoadipate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71860", "l": "glycochenodeoxycholate(out) => glycochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709109", "l": "DHFR dimer binds DHFR inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172678", "l": "PHF8 demethylates histone H4K20me1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67006", "l": "a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate => a 5'-end triphospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0015343", "l": "siderophore-iron transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51426", "l": "ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate => a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59435", "l": "3-hydroxypropanal + H2O + NAD(+) <=> 3-hydroxypropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37091", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20034", "l": "isopenicillin N => penicillin N", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27642", "l": "adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392530", "l": "p-S400-Cot phosphorylates NIK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35888", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694583", "l": "ABHD4 hydrolyses NAPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.108", "l": "\"nocturnin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664567", "l": "ERBB2 KD mutants heterodimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016499", "l": "orexin receptor activity", "d": ["Combining with orexin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74267", "l": "n H(+)(out) + spermidine(in) = n H(+)(in) + spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340226", "l": "CYGB dioxygenates NO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0043797", "l": "glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018758", "l": "RHOH binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11968", "l": "AH2 + kynurenate + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": [], "t": []}, {"i": "EC:1.14.99.2", "l": "\"kynurenine 7,8-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2752115", "l": "SPP1 (osteopontin) binds CD44 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140090", "l": "membrane curvature sensor activity", "d": ["Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77160", "l": "H2O + selenophosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-1-seleno-beta-D-glucosamine + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187506", "l": "Translocation of p27 to the nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36778", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-L-Fuc-(1->2)-[alpha-D-Gal-(1->3)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140765", "l": "NAD-dependent histone H3K56 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + H2O = histone H3 L-lysine (position 56) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 56 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51518", "l": "(R)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51082", "l": "19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050089", "l": "mannose isomerase activity", "d": ["Catalysis of the reaction: D-mannose = D-fructose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38509", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19779", "l": "AH2 + H(+) + L-1-piperideine-6-carboxylate => A + L-pipecolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113402", "l": "Formation of DSIF:NELF:early elongation complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20216", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] <=> L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17713", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": [], "t": []}, {"i": "EC:1.14.19.67", "l": "\"salutaridine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33173", "l": "D-maltose(out) => D-maltose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25559", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemod-13(17)-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018756", "l": "RHOH binds GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781941", "l": "WNTs are secreted in exosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769397", "l": "SOST binds LRP5/6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66157", "l": "butanoyl-CoA + tyramine => CoA + H(+) + N-butanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25540", "l": "ent-copalyl diphosphate = diphosphate + ent-pimara-8(14),15-diene", "d": [], "t": []}, {"i": "EC:4.2.3.30", "l": "\"ent-pimara-8(14),15-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42050", "l": "acetoacetyl-CoA + H(+) + NADH => 3-hydroxybutanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66853", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31693", "l": "(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28863", "l": "H(+)(out) + lactose(in) = H(+)(in) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73079", "l": "S-adenosyl-L-methionine + scutellarein = S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444523", "l": "CXCR5 binds CXCL13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51175", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30836", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803890", "l": "SFN dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018749", "l": "(3,5-dichlorophenylurea)acetate amidohydrolase activity", "d": ["Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43419", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.2", "l": "\"dichlorochromopyrrolate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109701", "l": "PDPK1 binds PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351849", "l": "Caspase-mediated cleavage of Etk (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11958", "l": "cholesterol + D-glucose => cholesteryl 3-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36298", "l": "alpha-maltose 6'-phosphate + H2O <=> D-maltose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42397", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine => 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191303", "l": "FDPS dimer transfers IPPP to GPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67369", "l": "H2O + N-acetyl-L-glutamine => acetate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48313", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928627", "l": "EPHB phosphorylates TIAM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20273", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": [], "t": []}, {"i": "EC:1.14.16.1", "l": "\"phenylalanine 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31260", "l": "but-3-ynal + H2O + NAD(+) => 3-butynoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13421", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.57", "l": "\"N-acylneuraminate-9-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18059", "l": "CO2 + hnu + oxidized Watasenia luciferin => O2 + Watasenia luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45477", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64924", "l": "dATP + 2 H2O = dAMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612509", "l": "SGK phosphorylates SRF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35946", "l": "brevianamide F + dimethylallyl diphosphate <=> deoxybrevianamide E + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052733", "l": "quinate 3-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102665", "l": "indole-3-acetyl-glutamate synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP = H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51398", "l": "CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51908", "l": "dATP + H2O = dADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75079", "l": "Formation of AT-AC C complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68102", "l": "H(+) + L-xylulose + NADH => NAD(+) + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35580", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 => anthocyanin A11 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46764", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.43", "l": "\"palmitoyl-[glycerolipid] 3-(E)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641231", "l": "TLE recruits HDAC1 to WNT promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50667", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793956", "l": "Defective B4GALT1 does not add Gal to N-glycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399712", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65116", "l": "2-oxoglutarate + aculene B + O2 = aculene A + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801776", "l": "REG3A binds bacterial phospholipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29862", "l": "5'-deoxyadenosine + H2O <=> 5-deoxy-D-ribose + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481009", "l": "Exocytosis of platelet dense granule content (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33287", "l": "A + spermidine = 1-pyrroline + AH2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9690461", "l": "FKBP1A binds tacrolimus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57092", "l": "AH2 + S-(methylsulfanyl)glutathione = A + glutathione + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655142", "l": "RCHY1 binds POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392834", "l": "Activation of EPACs by cAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41155", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43500", "l": "beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10602", "l": "prostaglandin D2 => prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016918", "l": "retinal binding", "d": ["Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694583", "l": "ABHD4 hydrolyses NAPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24508", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2", "d": [], "t": []}, {"i": "EC:1.1.1.189", "l": "\"prostaglandin-E2 9-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106286", "l": "(E)-caffeate-CoA ligase activity", "d": ["Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate."], "t": []}, {"i": "RHEA:36299", "l": "(E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754129", "l": "CDK6 inhibitors bind CDK6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202947", "l": "Caspase mediated cleavage of APC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.93", "l": "\"proprotein convertase 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35294", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40472", "l": "(2S)-methylpentadecanoyl-CoA + O2 => 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021050", "l": "HSBP1 oligomer binds ESRs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70755", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865276", "l": "PDGF-AB clevage by Furin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015092", "l": "high-affinity ferric iron transmembrane transporter activity", "d": ["Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047341", "l": "fucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17216", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11003", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O <=> a D-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983700", "l": "SYK binds the activated BCR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853920", "l": "VENTX binds the CDKN2A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204311", "l": "AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.12", "l": "\"ABC-type cystine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45497", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870465", "l": "RGGT binds the RAB-binding subunit (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70681", "l": "glycine betaine(out) + H(+)(out) => glycine betaine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23053", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005160", "l": "transforming growth factor beta receptor binding", "d": ["Binding to a transforming growth factor beta receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210274", "l": "SIRP beta binds TYROBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21272", "l": "ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761344", "l": "USP18 binds IKBKG within IKK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49939", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0001056", "l": "RNA polymerase III activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}, {"i": "REACT:R-HSA-1964482", "l": "RNA polymerase III transcribes microbial dsDNA to dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67646", "l": "ADP + dZTP => ATP + dZDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50815", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42762", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADH => D-glyceraldehyde 3-phosphate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39184", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59374", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+) => 1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69901", "l": "2 Na(+)(in) + thymidine(in) => 2 Na(+)(out) + thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084990", "l": "Nuclear CMP-Neu5Ac translocates to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2219524", "l": "PDPK1 binds PIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009017", "l": "succinylglutamate desuccinylase activity", "d": ["Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35229", "l": "H(+)(in) + rifampicin(out) => H(+)(out) + rifampicin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865994", "l": "GAB1 binds PTPN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853496", "l": "SCF:FBXL7 binds AURKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047215", "l": "indole-3-acetate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18843", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADPH => (R)-glycerate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35593", "l": "H(+) + hydrogen sulfide + (n-1) sulfur => H2 + n sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102787", "l": "caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40630", "l": "H2O + trihexadecanoylglycerol <=> 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39147", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614544", "l": "Sulfite is oxidized to sulfate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158849", "l": "Phenol can form a sulfate conjugate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112755", "l": "SOCS3 binds IL6ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76489", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17753", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": [], "t": []}, {"i": "EC:4.4.1.21", "l": "\"S-ribosylhomocysteine lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23462", "l": "benzyl alcohol + cetraxate + H(+) => benzyl cetraxate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13732", "l": "FAD <=> AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416562", "l": "p190RhoGAP binds Plexin-B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39064", "l": "NADP(+) + scyllo-inositol => H(+) + NADPH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675417", "l": "PEBP1 binds activated RAF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34667", "l": "C30 botryococcene + S-adenosyl-L-methionine = 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60447", "l": "an S-substituted L-cysteinylglycine + H2O <=> an S-substituted L-cysteine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29381", "l": "2'-deoxyguanosine + phosphate => dGMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25781", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine => 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29177", "l": "2 H(+) + 2 superoxide + ubiquinone-8 => 2 O2 + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60729", "l": "citral + H2O + NADP(+) => 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52317", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69287", "l": "a 17beta-hydroxy steroid + NADP(+) <=> a 17-oxo steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14365", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate = CO2 + L-aspartate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.7", "l": "\"ureidosuccinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41384", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59269", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] => AH2 + formaldehyde + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052668", "l": "CTP:farnesol kinase activity", "d": ["Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607746", "l": "PKC-delta is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29483", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167511", "l": "HLCS biotinylates ACACB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58145", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) => AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417842", "l": "P2Y10 receptor can bind to LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75207", "l": "Ag(+)(out) = Ag(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29356", "l": "dUMP + H2O => 2'-deoxyuridine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11070", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62322", "l": "(+)-isomalbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-877187", "l": "P2X7 mediates loss of intracellular K+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27819", "l": "L-idonate + NAD(+) => 2-dehydro-L-idonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10398", "l": "a 2-oxocarboxylate + H(+) + NADH + NH4(+) => an L-alpha-amino acid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190265", "l": "FGFR4 binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60697", "l": "(R)-lavandulyl diphosphate + H2O => (R)-lavandulol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17997", "l": "Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.151", "l": "\"cobalt-factor II C(20)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45531", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52889", "l": "N-phenylhydroxylamine + NADP(+) => H(+) + NADPH + nitrosobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3321805", "l": "NSL acetylates histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18039", "l": "N-carbamoylputrescine + NH4(+) => agmatine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.201", "l": "\"exo-chitinase (reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20909", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66023", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660665", "l": "Caspase-8 binds MALT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68615", "l": "Formation of ORC(1-6) complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418456", "l": "cGMP is degraded by PDEs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33806", "l": "H2O + L-histidinal + NAD(+) <=> 2 H(+) + L-histidine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46117", "l": "2-dehydro-3-deoxy-D-galactonate => D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050640", "l": "isopenicillin-N N-acyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34747", "l": "15-methylhexadecasphinganine + ATP = 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:0005402", "l": "carbohydrate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072549", "l": "monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36095", "l": "S-adenosyl-L-methionine + salicylate = methyl salicylate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.274", "l": "\"salicylate carboxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74008", "l": "dimethylallyl diphosphate + H2O + yaequinolone E => [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805285", "l": "PLK3 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40899", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73424", "l": "L-asparagine(out) => L-asparagine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10705", "l": "ATP + L-valine + tRNA(Val) => AMP + diphosphate + L-valyl-tRNA(Val)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38999", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004526", "l": "ribonuclease P activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615933", "l": "SUMOylation of CBX5 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15332", "l": "(S)-ureidoglycolate + NAD(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12183", "l": "anthranilate + S-adenosyl-L-methionine <=> H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64579", "l": "2 Fe(III)-[cytochrome b5] + NADPH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173705", "l": "C5b binds C6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57208", "l": "glyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58646", "l": "(9Z,12Z,15Z)-octadecatrienamide + glyoxylate => N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42902", "l": "H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(745) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14867", "l": "H(+) + N-methyltyramine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804425", "l": "TP53 binds POU4F2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983142", "l": "Formation of peptide loading complex (PLC) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43246", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879222", "l": "MDP:NLRP1 binds ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863463", "l": "STON2 binds SYT proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698021", "l": "PTPN11:p-STAT5 binds BCL2L1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53800", "l": "lithocholoyl-CoA + ursodeoxycholate = lithocholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983696", "l": "The Immunoglobulin of the BCR binds antigen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70107", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide = H(+) + penilactone D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51598", "l": "4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56937", "l": "17beta-hydroxy-androst-5-en-3-one => testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517674", "l": "p-S158,221-HuR binds mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65102", "l": "an hexadecanoyl-acylglycerol + CoA => a 1-acylglycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66151", "l": "2-phenylethylamine + acetyl-CoA <=> CoA + H(+) + N-(2-phenylethyl)acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18095", "l": "H(+) + NADPH + uracil => 5,6-dihydrouracil + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36846", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18036", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19900", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14907", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine => 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44021", "l": "H2O + NAD(+) + octadecanal => 2 H(+) + NADH + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769044", "l": "NPAS4 binds IQSEC3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19381", "l": "(S)-oxalosuccinate + H(+) = 2-oxoglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.-", "l": "\"Oxo-acid-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37302", "l": "H2O + L-alanyl-L-threonine <=> L-alanine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948136", "l": "ULK1 Translocates to the mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018485", "l": "salicylaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202437", "l": "Phosphorylation of CARMA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161588", "l": "Delta12-PGJ2 is dehydrated to 15d-PGJ2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37438", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671993", "l": "CIT-3 binds DLG4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844438", "l": "NLRP1 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26278", "l": "Co-precorrin-4 + S-adenosyl-L-methionine => Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53389", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56910", "l": "acetate + H(+) + thebaine => (7S)-O-acetylsalutaridinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44458", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788623", "l": "p-Y-STATs translocate to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373724", "l": "Nephrin binds NCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56638", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27408", "l": "a ubiquinone + H2O + pyruvate <=> a ubiquinol + acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.149", "l": "\"20alpha-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045431", "l": "flavonol synthase activity", "d": ["Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27647", "l": "inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74074", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097429", "l": "amino acid ligation activity by nonribosomal peptide synthase", "d": ["Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13017", "l": "diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": [], "t": []}, {"i": "EC:2.4.2.9", "l": "\"uracil phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64678", "l": "butyl 3-(methylsulfanyl)propanoate + CoA => 3-(methylsulfanyl)propanoyl-CoA + butan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28225", "l": "3-dehydro-L-gulonate + ATP <=> 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13382", "l": "acetate + an acyl-CoA => a carboxylate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70173", "l": "H(+)(out) + pemetrexed(out) => H(+)(in) + pemetrexed(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008719", "l": "dihydroneopterin triphosphate 2'-epimerase activity", "d": ["Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173739", "l": "Spontaneous hydrolysis of C3 thioester (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64511", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3777129", "l": "HDAC3 containing complexes deacetylate histone (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73781", "l": "diphosphate + tardioxopiperazine A => dimethylallyl diphosphate + preechinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21260", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": [], "t": []}, {"i": "EC:1.8.4.14", "l": "\"L-methionine (R)-S-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983709", "l": "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57445", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72522", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate <=> 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65078", "l": "asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16217", "l": "H2O + L-arabinono-1,4-lactone = H(+) + L-arabinonate", "d": [], "t": []}, {"i": "EC:3.1.1.15", "l": "\"L-arabinonolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17555", "l": "ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate => ATP + guanidinoethyl methyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58003", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg3 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65946", "l": "3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + CTP + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928619", "l": "PAK1 binds RAC1:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77742", "l": "a 1,2-diacylglycerol + a glycerophospholipid <=> a 1-acyl-sn-glycero-3-phospholipid + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018808", "l": "RAC3 binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32161", "l": "A + H2O + queuosine(34) in tRNA => AH2 + epoxyqueuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11149", "l": "4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26096", "l": "(4R)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951676", "l": "RUNX3 binds TEADs and YAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18551", "l": "[(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56191", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17565", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.40", "l": "\"inositol 1-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210439", "l": "glutamate uptake by astrocytes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445079", "l": "Phosphorylation of L1 by ERK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664879", "l": "ATM:PEX5 binds ATM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71147", "l": "3-hydroxyhispidin + O2 = 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22410", "l": "(2E)-geranyl diphosphate + diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001068", "l": "arabinoxylan binding", "d": ["Binding to arabinoxylan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467811", "l": "Separation of sister chromatids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33839", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) = 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.125", "l": "\"7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473596", "l": "Collagen type I degradation by MMP15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0072542", "l": "protein phosphatase activator activity", "d": ["Binds to and increases the activity of a protein phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176116", "l": "Recruitment and activation of Chk1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71732", "l": "citrate(out) + tartrate(in) => citrate(in) + tartrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663511", "l": "BIL binds GSTA1, FABP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74170", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] <=> formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54678", "l": "(+)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002039", "l": "p53 binding", "d": ["Binding to one of the p53 family of proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61608", "l": "[DsbB protein]-dithiol + a quinone = [DsbB protein]-disulfide + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928625", "l": "PAKs autophosphorylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008396", "l": "oxysterol 7-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212352", "l": "Formation of ARC coactivator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10743", "l": "a secondary alcohol + NAD(+) <=> a ketone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55493", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57188", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130706", "l": "MHC class II antigen processing (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75383", "l": "bromide(in) = bromide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43277", "l": "a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GalNAc-GD1a + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047040", "l": "pteridine reductase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76563", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114684", "l": "Phosphorylation of Syntaxin-4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54522", "l": "cycloaraneosene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782637", "l": "HDAC8 deacetylates histones (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44812", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16362", "l": "2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48272", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37581", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004177", "l": "aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65329", "l": "A + chrodrimanin F => AH2 + chrodrimanin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23030", "l": "acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68581", "l": "ATP + H2O + L-kynurenine(out) => ADP + H(+) + L-kynurenine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35858", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56384", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592362", "l": "Activation of proMMP7 by MMP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32441", "l": "albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858489", "l": "ppDVL binds DAAM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15890", "l": "H2O + L-glutamine => L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49169", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299318", "l": "Activation of TASK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26241", "l": "geranylgeranyl diphosphate = diphosphate + elisabethatriene", "d": [], "t": []}, {"i": "EC:4.2.3.41", "l": "\"elisabethatriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802935", "l": "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240783", "l": "E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45795", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 <=> [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25495", "l": "(2E)-geranyl diphosphate <=> (-)-beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833446", "l": "NS1 (1C) binds to CREBBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74631", "l": "3-methyl-2-oxobutanoate + O-acetyl-L-homoserine = (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41574", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => lipoxin A4 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047096", "l": "androst-4-ene-3,17-dione monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33145", "l": "galactitol(out) => galactitol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74323", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) = O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62459", "l": "ATP + H(+) + L-glutamate <=> diphosphate + L-glutamyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36438", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) <=> a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055055", "l": "D-glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299359", "l": "Activation of TALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48808", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77192", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029449", "l": "Phosphorylation of SYK by Src kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53335", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855111", "l": "VLDLR binds PCSK9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64446", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23939", "l": "D-gluconate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52763", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O <=> (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194809", "l": "botD LC cleaves target cell VAMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904854", "l": "proteasome core complex binding", "d": ["Binding to a proteasome core complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791164", "l": "Expression of SSR1 (Trap alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54496", "l": "ent-copalyl diphosphate = diphosphate + ent-atiserene", "d": [], "t": []}, {"i": "EC:4.2.3.185", "l": "\"ent-atiserene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64175", "l": "L-altrarate <=> galactarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47122", "l": "H2O + N-docosanoylglycine => docosanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48484", "l": "a propanoate ester + H2O = an aliphatic alcohol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3321883", "l": "MSL acetylates histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46422", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66235", "l": "IC-asc-C7-CoA + O2 <=> H2O2 + IC-asc-DeltaC7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033925", "l": "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity", "d": ["Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617595", "l": "SGTA binds mislocalized membrane protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25722", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58449", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50712", "l": "chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.49", "l": "\"tetracycline 7-halogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11240", "l": "ATP + thiamine diphosphate = ADP + thiamine triphosphate", "d": [], "t": []}, {"i": "EC:2.7.4.15", "l": "\"thiamine-diphosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38870", "l": "uridine(516) in 16S rRNA <=> pseudouridine(516) in 16S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25518", "l": "CoA + H(+) + O-acyltropine => an acyl-CoA + tropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686071", "l": "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.48", "l": "\"low-specificity L-threonine aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420975", "l": "Ca impermeable AMPA receptor ligand binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693593", "l": "D-loop extension by DNA polymerases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190256", "l": "FGFR1c binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.410865998300608", "identifiers": [{"i": "GO:0043169", "l": "cation binding", "d": ["Binding to a cation, a charged atom or group of atoms with a net positive charge."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72180", "l": "Cleavage of mRNA at the 3'-end (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51603", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55503", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008412", "l": "CDK4 phosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788623", "l": "p-Y-STATs translocate to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956659", "l": "ABL1 phosphorylates YAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25784", "l": "2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.53", "l": "\"2-keto-3-deoxy-L-rhamnonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791138", "l": "Expression of TPP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74960", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] => (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22401", "l": "androstan-3alpha,17beta-diol + NAD(+) => 17beta-hydroxyandrostanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702601", "l": "midostaurin-resistant FLT3 mutants don't bind midostaurin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64633", "l": "acetyl-CoA + butan-1-ol => butyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750666", "l": "ALB binds ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66627", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56037", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71557", "l": "5-aminoethyl-dUMP in DNA + CO2 => 5-C(alpha)-glycyl-dTMP in DNA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71293", "l": "(R)-carnitine(in) + chloride(in) + 2 Na(+)(in) => (R)-carnitine(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000140", "l": "acylglycerone-phosphate reductase activity", "d": ["Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814555", "l": "Integrator complex processes the 3' end of snRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17019", "l": "CoA + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] => acetyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821368", "l": "AKAP8L binds MLL1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52310", "l": "2-oxoglutarate + H(+) + NADPH => 2-hydroxyglutarate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31597", "l": "(Z)-2-methylaminoacrylate + carbamate + H(+) => (Z)-2-methylureidoacrylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38317", "l": "3-hydroxybenzoate + pyruvate => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018826", "l": "RHOT2 hydrolyzes GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74266", "l": "n H(+)(out) + spermine(in) <=> n H(+)(in) + spermine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13272", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62883", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 <=> (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35191", "l": "noranthrone + O2 = H2O + norsolorinic acid", "d": [], "t": []}, {"i": "EC:1.13.12.20", "l": "\"noranthrone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730872", "l": "Activation of Calcineurin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43826", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199404", "l": "CD40L binds CD40 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67703", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030771", "l": "N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity", "d": ["Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27587", "l": "L-tryptophan + pyruvate => indole-3-pyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.23", "l": "\"ribotoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35351", "l": "NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46278", "l": "(S)-lactate + CO2 => (S)-malate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10938", "l": "6-decylubiquinol + tetrathionate => 6-decylubiquinone + 2 thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37837", "l": "epsilon-rhodomycinone + H2O + NADP(+) => aklavinone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019160", "l": "NMN nucleosidase activity", "d": ["Catalysis of the reaction: H2O + nicotinamide mononucleotide = D-ribose 5-phosphate + H+ + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66936", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate = avenanthramide C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731149", "l": "Syndecan-4 binds ACTN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16636", "l": "guanosine(34) in tRNA + queuine <=> guanine + queuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990430", "l": "extracellular matrix protein binding", "d": ["Binding to a protein that is part of an extracellular matrix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56185", "l": "a globoside Gb4Cer + UDP-alpha-D-galactose => a globoside NOR1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990447", "l": "U2 snRNP binding", "d": ["Binding to a U2 small nuclear ribonucleoprotein particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72539", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109860", "l": "MAP2K1 phosphorylates MAPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2214351", "l": "PLK1 phosphorylates GORASP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76895", "l": "2-hexyl-5-pentylresorcinol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hexyl-5-(5-hydroxypentyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18462", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696958", "l": "USP44 deubiquitinates CDC20 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20855", "l": "ATP + H(+)(in) + H2O <=> ADP + 2 H(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18938", "l": "an N-acyl-L-homoserine lactone + H2O => a carboxylate + L-homoserine lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010491", "l": "UTP:arabinose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10720", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": [], "t": []}, {"i": "EC:1.5.4.1", "l": "\"pyrimidodiazepine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140592", "l": "histone H3R8 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788622", "l": "p-Y-STATs dimerize (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70441", "l": "a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62960", "l": "7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52737", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate => (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62795", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B <=> 2 H2O + NADP(+) + nigerone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29043", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": [], "t": []}, {"i": "EC:2.1.1.148", "l": "\"thymidylate synthase (FAD)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47840", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.131", "l": "\"(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790038", "l": "Expression of HSP90B1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420265", "l": "AMY1-3 bind IAPP(34-70) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21767", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40925", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71696", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) => 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015374", "l": "neutral, basic amino acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102544", "l": "ornaline synthase activity", "d": ["Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ = ornaline + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30868", "l": "H2O + indole-3-acetaldehyde + NAD(+) => (indol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667619", "l": "AVPR1A,B,2 bind atosiban (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53328", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine = 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74838", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) <=> UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10246", "l": "acetoacetate + fumarate + H(+) => 4-fumarylacetoacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15392", "l": "ATP <=> 3',5'-cyclic AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629369", "l": "NEIL3 recognizes and binds to thymine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65463", "l": "acetyl-CoA + hexan-1-ol <=> CoA + hexyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63145", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine => (15Z)-tetracosenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68799", "l": "D-maltose + H2O <=> alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226999", "l": "ADD1:ADD3 binds DMTN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64436", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53297", "l": "(2E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60014", "l": "a tRNA with a 3' CCA end + diphosphate => a tRNA with a 3' CC end + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45134", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54665", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene => pre-alpha-onocerin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012835", "l": "GDIs block activation of RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12436", "l": "(E)-caffeoyl-CoA + putrescine = CoA + H(+) + N-caffeoylputrescine", "d": [], "t": []}, {"i": "EC:2.3.1.138", "l": "\"putrescine N-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49918", "l": "(R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022065", "l": "DSPGs are secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33022", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA <=> (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805638", "l": "KAT6A acetylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691167", "l": "CUL1, SKP1, FBXL5 bind (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757954", "l": "N4BP1 binds IKBKG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432121", "l": "LDL binds to LRP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22379", "l": "uridine(38/39/40) in tRNA <=> pseudouridine(38/39/40) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862700", "l": "CMKLR1 binds Resolvin E1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082356", "l": "HSF1-mediated gene expression (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28898", "l": "cadaverine(in) + L-lysine(out) <=> cadaverine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604471", "l": "FLT4 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46073", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH => hexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37101", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69473", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70846", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) <=> L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44764", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16290", "l": "(1R,2S)-ephedrine + NAD(+) => (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63354", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17035", "l": "biphenyl-2,3-diol + H(+) + NADH => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20302", "l": "ATP + L-arginine + tRNA(Arg) => AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72755", "l": "3 ATP = 3',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45824", "l": "H(+) + L-serine = CO2 + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.62", "l": "\"magnolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686578", "l": "Activated ATM phosphorylates ABL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665525", "l": "sCD163 translocates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60944", "l": "quercetin + S-adenosyl-L-methionine = H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788628", "l": "p-Y-STATs dissociate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202721", "l": "JAM2 binds JAM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0003712", "l": "transcription coregulator activity", "d": ["A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28302", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene C", "d": [], "t": []}, {"i": "EC:4.2.3.60", "l": "\"germacrene C synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66946", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76652", "l": "3-methylbutanal + H2O + NADP(+) => 3-methylbutanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42456", "l": "4alpha-methylzymosterol = zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687585", "l": "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14338", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate => adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39296", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33554", "l": "an N-acylsphinganine + H2O <=> a fatty acid + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12633", "l": "benzoate + H(+) + NADH + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.10", "l": "\"benzoate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12194", "l": "(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74723", "l": "Endosome acidification (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20699", "l": "2 H(+) + 2 superoxide <=> H2O2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45435", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73993", "l": "beta-araneosene + diphosphate => geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618328", "l": "ATAT acetylates microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794346", "l": "NRXNs bind NLGNs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74059", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433451", "l": "JAK2 binds to p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62491", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65258", "l": "A + H2O + verruculide C epoxide => AH2 + O2 + verruculide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58637", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => (9Z)-octadecenamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48393", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665311", "l": "ERBB2 T798M does not bind afatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71649", "l": "a medium-chain (2E)-enoyl-CoA + H2O => a medium-chain (3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373707", "l": "Netrin-1 induced DCC clustering (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54501", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => beta-geranylfarnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.358", "l": "\"2-dehydropantolactone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132269", "l": "Formation of classical C5 convertase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27419", "l": "6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+) => 2 Fe(III)-[cytochrome] + H2O + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874187", "l": "MBTPS2 (S2P) cleaves CREB3L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71348", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) => chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030251", "l": "guanylate cyclase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of guanylate cyclase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69849", "l": "a uridine in RNA + H(+) + NADPH => a 5,6-dihydrouridine in RNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379387", "l": "COMT transfers Met to DA to form 3MT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50508", "l": "acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46913", "l": "H2O + juvenile hormone III => H(+) + juvenile hormone III carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043861", "l": "agmatine:putrescine antiporter activity", "d": ["Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56958", "l": "H(+) + IDP + phosphoenolpyruvate => ITP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46081", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH => NAD(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015255", "l": "propanediol channel activity", "d": ["Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19014", "l": "dTTP + H2O => dTDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018734", "l": "butyrolactone hydrolase activity", "d": ["Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218832", "l": "CDC42:GTP binds PAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018452", "l": "5-exo-hydroxycamphor dehydrogenase activity", "d": ["Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050022", "l": "L-arabinose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134519", "l": "TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050314", "l": "sym-norspermidine synthase activity", "d": ["Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28315", "l": "baicalein + UDP-alpha-D-glucuronate => baicalin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11880", "l": "(S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.5", "l": "\"(S)-6-hydroxynicotine oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0062179", "l": "vitamin D 23-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-23 of any form of vitamin D."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620456", "l": "sGC stimulators bind sGC:NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65273", "l": "chrodrimanin C + H(+) + NADPH + O2 => chrodrimanin H + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052605", "l": "gamma-tocopherol cyclase activity", "d": ["Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823952", "l": "EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17129", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.3", "l": "\"phosphoribosylformylglycinamidine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42179", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65848", "l": "A + a 3-oxo-Delta(1)-steroid + H2O = a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609921", "l": "SGTA binds Tail-anchored protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53041", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68096", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212614", "l": "Glutamine transport from astrocytes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909552", "l": "Phosphorylation of STAT1 at Ser727 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43369", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683831", "l": "CCDC59 binds TTF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682992", "l": "KDM4A,B bind H4K20Me2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629679", "l": "PDE3A inhibitors bind PDE3A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671850", "l": "JAK2 Phosphoryates STAT3 in Response to Leptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25372", "l": "(2S)-2-amino-4-deoxychorismate + FMN => 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37406", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391377", "l": "Luteinizing hormone receptor can bind LH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801675", "l": "PLK2 phosphorylates NPM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32992", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22417", "l": "3,4-dihydroxybenzoate + H(+) => catechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10195", "l": "ATP + H2O + sulfate(out) <=> ADP + H(+) + phosphate + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008962", "l": "phosphatidylglycerophosphatase activity", "d": ["Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25843", "l": "5-deoxy-D-glucuronate <=> 5-dehydro-2-deoxy-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034848", "l": "naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity", "d": ["Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59563", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone <=> H(+) + N,N',N''-triacetylchitotrionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371422", "l": "ATP hydrolysis by HSP70 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607745", "l": "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40152", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75077", "l": "dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58510", "l": "(2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40596", "l": "dodecanedioyl-CoA + H2O => CoA + dodecanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217255", "l": "FMO1:FAD N-oxidises TAM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49738", "l": "CO2 + deoxyviolacein + 2 H2O + NAD(+) => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800490", "l": "ATM phosphorylates PIDD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65939", "l": "beta-D-mannose <=> beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58520", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56980", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] = 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59277", "l": "L-glutamine => D-glutamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052875", "l": "riboflavin reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + 2 H+. This reaction can utilize NADH and NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25545", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-9(11),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53120", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444433", "l": "Cho transports from the extracellular space to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296309", "l": "HCAR3 binds HCAR3 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15161", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351948", "l": "Mitochondrial recruitment of Drp1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67545", "l": "(9Z)-tetradecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57060", "l": "2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42925", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46974", "l": "AH2 + bisanhydrobacterioruberin => A + dihydrobisanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76023", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679045", "l": "C-ter TLR9 dimer binds HCQ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66734", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35516", "l": "4'''-demalonylsalvianin + malonyl-CoA => CoA + salvianin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102416", "l": "quercetin gentiotrioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose = quercetin-3-gentiotetraside + UDP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59963", "l": "N(alpha)-acetyl-D-methionine <=> N(alpha)-acetyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44680", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15900", "l": "4-acetamidobutanoate + H2O <=> 4-aminobutanoate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416516", "l": "GRK2 sequesters activated Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008401", "l": "retinoic acid 4-hydroxylase activity", "d": ["Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714691", "l": "RAC3 binds ER effectors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73911", "l": "ATP + psilocin = ADP + H(+) + psilocybin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12351", "l": "(S)-muconolactone <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56852", "l": "reumycin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30492", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11701", "l": "H(+) + NADPH + O2 + progesterone => H2O + NADP(+) + testosterone acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614460", "l": "Dimerization of procollagen type VI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67398", "l": "5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836034", "l": "TFAP2A:TFAP2B binds the GBX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19944", "l": "norcoclaurine + S-adenosyl-L-methionine <=> coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67671", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129353", "l": "Tropoelastin associates with microfibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42972", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028730", "l": "Activated NTRK2 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74420", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62086", "l": "AMP + D-glucosamine 6-phosphate + H(+) => ADP + D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.46", "l": "\"L-arabinose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031751", "l": "D4 dopamine receptor binding", "d": ["Binding to a D4 dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004356", "l": "glutamine synthetase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603784", "l": "PEX19:class I PMP binds PEX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19175", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673794", "l": "ppDVL:RAC1:GTP binds NOX1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869438", "l": "Dissociation of clathrin-associated proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50161", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29875", "l": "H2O + sn-glycero-3-phospho-L-serine = H(+) + L-serine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17115", "l": "H(+) + L-serine + phosphoethanolamine => H2O + L-serine-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174097", "l": "Association of Emi1 with Cdh1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66177", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15316", "l": "ethanolamine <=> acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.31", "l": "\"D-tagatose 3-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606349", "l": "Mis18 complex binds the centromere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70757", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201630", "l": "Caspase-mediated cleavage of Acinus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16156", "l": "an aliphatic amine + H2O + O2 <=> an aldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70907", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015243", "l": "cycloheximide transmembrane transporter activity", "d": ["Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840564", "l": "OMA1 hydrolyzes YME1L1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4649028", "l": "TLE forms non-functional complexes with AES (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18581", "l": "ethanolamine + H2O + O2 = glycolaldehyde + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.8", "l": "\"ethanolamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76028", "l": "(S)-reticuline + 2-oxoglutarate + O2 => (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708275", "l": "PDE4A binds PDE4A inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.883104846989859", "identifiers": [{"i": "GO:0005245", "l": "voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002460", "l": "P4HB binds Collagen chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379387", "l": "COMT transfers Met to DA to form 3MT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12967", "l": "1-phospho-alpha-D-galacturonate + ADP + H(+) => ATP + D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18846", "l": "(R)-glycerate + NAD(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66665", "l": "ATP + coproporphyrin III(in) + H2O => ADP + coproporphyrin III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14615", "l": "ADP + H(+) + phosphate + taurine(in) => ATP + H2O + taurine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0018271", "l": "biotin-protein ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661217", "l": "MT1A binds zinc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018622", "l": "4-chlorophenylacetate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41101", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23683", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481009", "l": "Exocytosis of platelet dense granule content (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036054", "l": "protein-malonyllysine demalonylase activity", "d": ["Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-874087", "l": "SGT1 binds HSP90 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72795", "l": "bilirubin-bisglucuronoside(out) = bilirubin-bisglucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043035", "l": "chromatin insulator sequence binding", "d": ["Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.39", "l": "\"alkylglycerophosphoethanolamine phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030270", "l": "formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H+ = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21249", "l": "a ribonucleoside 5'-triphosphate + RNA(n) => diphosphate + RNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27633", "l": "ethylene glycol + NAD(+) <=> glycolaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40435", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.304", "l": "\"poly[(R)-3-hydroxyalkanoate] polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417842", "l": "P2Y10 receptor can bind to LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72341", "l": "catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035539", "l": "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26231", "l": "geranylgeranyl diphosphate + 3 H(+) + 3 NADPH => 3 NADP(+) + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45206", "l": "H2O + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14298", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046820", "l": "4-amino-4-deoxychorismate synthase activity", "d": ["Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31822", "l": "(2E,6E)-farnesyl diphosphate <=> 5-epi-alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736953", "l": "FURIN translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76738", "l": "decane + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-decanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706399", "l": "RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016483", "l": "tryptophan hydroxylase activator activity", "d": ["Increases the activity of the enzyme tryptophase hydroxylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.66", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39581", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67305", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => H2O2 + myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375140", "l": "CDO binds promyogenic cadherins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71849", "l": "LDH tetramer reduces PYR to LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52679", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34209", "l": "beta-D-glucose 1-phosphate + L-rhamnopyranose => 3-O-alpha-D-glucosyl-L-rhamnose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74072", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52909", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 => 3-dimethylallyl-4-hydroxymandelate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39214", "l": "(3R)-hydroxyhexacosanoyl-CoA <=> (2E)-hexacosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59258", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => Fe(III)-enterobactin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444516", "l": "Formation of MSH2:MSH6 Complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76983", "l": "1-(9Z-octadecenoyl)-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O = (9Z)-octadecenoate + 2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22663", "l": "a fatty acid + ATP + holo-[ACP] <=> a fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032775", "l": "YAP1 binds TEAD1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382055", "l": "Grb7 binds to the active PDGF receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654623", "l": "Activated FGFR3 binds FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008877", "l": "glucose-1-phosphatase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32647", "l": "erythromycin C + S-adenosyl-L-methionine = erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003943", "l": "N-acetylgalactosamine-4-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730892", "l": "Recruitment of VAV to p-SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29594", "l": "2-hydroxyethane-1-sulfonate + NADP(+) <=> H(+) + NADPH + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49758", "l": "CO2 + H2O + proviolacein => H(+) + O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74733", "l": "Insulin receptor de-phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251942", "l": "Hikeshi binds HSP70s:ATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75156", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + verrucosan-2beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166091", "l": "IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428535", "l": "Activation of RAC1 by SOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45777", "l": "(indol-3-yl)acetonitrile + 2 H2O => (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617828", "l": "TRIP11:IFT20 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55879", "l": "apo-[aequorin] + coelenterazine <=> apo-[aequorin]--coelenterazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35317", "l": "3-oxooctadecanoyl-CoA + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12020", "l": "a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43226", "l": "(24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49745", "l": "deoxyviolaceinate + H(+) + O2 => CO2 + deoxyviolacein + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46473", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21680", "l": "(2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.27", "l": "\"hydroxyphytanate oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43370", "l": "4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA => dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28333", "l": "H2O + ITP <=> H(+) + IDP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34270", "l": "acetyl-CoA + fumigaclavine B <=> CoA + fumigaclavine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637635", "l": "esxA binds B2M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69127", "l": "Formation of the Flap Intermediate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047954", "l": "glycerol-2-phosphatase activity", "d": ["Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627350", "l": "SMAC (DIABLO) binds XIAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56448", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74009", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate => dimethylallyl diphosphate + H2O + yaequinolone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639286", "l": "RRAGC,D exchanges GTP for GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59829", "l": "H2O + S-inosyl-L-homocysteine => inosine + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65646", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine => (4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51113", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40499", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56550", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71194", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) <=> an L-alpha-amino acid(out) + L-kynurenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013143", "l": "RAC1 GEFs activate RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615042", "l": "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421508", "l": "Synthesis of ALAS1 nascent polypeptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47739", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199839", "l": "AKT can phosphorylate RSK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23228", "l": "L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.59", "l": "\"L-lysine N(6)-monooxygenase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37088", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36756", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76261", "l": "H(+)(out) + taurine(out) => H(+)(in) + taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46029", "l": "H2O2 + tetradecanoate => (2R)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62849", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71037", "l": "L-phenylalanine(in) + L-serine(out) => L-phenylalanine(out) + L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781814", "l": "USP19 deubiquitinates RNF123 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52671", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63119", "l": "peroxynitrite <=> nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23486", "l": "AH2 + D-cellobiono-1,5-lactone => A + D-cellobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30243", "l": "4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical", "d": [], "t": []}, {"i": "EC:1.10.3.3", "l": "\"L-ascorbate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109700", "l": "AKT2 binds PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39818", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate <=> (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008715", "l": "CDP-diacylglycerol diphosphatase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761846", "l": "NFE2L2-dependent PGD gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71692", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) => glycyl-L-glutamate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28440", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464822", "l": "RDH12 reduces atRAL to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50371", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 <=> 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27890", "l": "3'-UMP + H2O = phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42356", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004676", "l": "3-phosphoinositide-dependent protein kinase activity", "d": ["Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}, {"i": "REACT:R-HSA-437195", "l": "PDPK1 activates PRKCZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.127", "l": "\"1,6-alpha-L-fucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18053", "l": "H2O + paraoxon = 4-nitrophenol + diethylphosphate + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.1.8.1", "l": "\"aryldialkylphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114284", "l": "Release of Cytochrome c from mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080044", "l": "quercetin 7-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043802", "l": "hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity", "d": ["Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H2O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H+ + hydrogenobyrinate a,c-diamide + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31087", "l": "acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35550", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14257", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.152", "l": "\"4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-915148", "l": "Correctly folded glycoproteins translocate to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110011", "l": "Binding of Grb10 to the insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48977", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + pyocyanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442862", "l": "Nuclear export of  p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77112", "l": "1D-myo-inositol 1,2,3,5,6-pentakisphosphate + H2O => 1D-myo-inositol 1,2,3,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912734", "l": "CBL:CRKL binds RAPGEF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981355", "l": "RASA1 binds RAS:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102526", "l": "8-demethylnovobiocic acid C8-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043250", "l": "sodium-dependent organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43634", "l": "an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe) => an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110218", "l": "Cleavage of uracil by TDG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862184", "l": "USP48 cleaves polyubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34155", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": [], "t": []}, {"i": "EC:2.3.1.202", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191299", "l": "Squalene is oxidized to its epoxide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48113", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-708349", "l": "Activated NOD2 oligomerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42191", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26419", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41278", "l": "H2O + N-eicosanoyl-sphing-4-enine <=> eicosanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710254", "l": "GSDME oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168046", "l": "Collagen type XII degradation by MMP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22091", "l": "ATP + GTP <=> AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65506", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17533", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59759", "l": "L-arginine + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0030284", "l": "nuclear estrogen receptor activity", "d": ["Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66622", "l": "(25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:0003777", "l": "microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47868", "l": "di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32845", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12033", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O => 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015412", "l": "ABC-type molybdate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28421", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA <=> (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008534", "l": "oxidized purine nucleobase lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12530", "l": "[hyaluronan](n+1) + H(+) + UDP => N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45906", "l": "dTDP + epivancomycin + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640195", "l": "RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67739", "l": "N-acetyl-alpha-neuraminate <=> aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211904", "l": "CYP4F12 18-hydroxylates ARA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.-.-", "l": "\"Acting on phosphorus-nitrogen bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45770", "l": "L-alaninol + L-glutamate => gamma-L-glutamyl-L-alaninol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71378", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) <=> 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18544", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine <=> dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44199", "l": "3-methylundecanoate + ATP + CoA <=> 3-methylundecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.46", "l": "\"6-aminohexanoate-oligomer exohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22863", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide <=> deamido-NAD(+) + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252133", "l": "ATP6AP1 binds V-ATPase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591052", "l": "PROCR binds Protein C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39435", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58961", "l": "benzaldehyde + H2O + O2 => benzoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374899", "l": "Release of noradrenaline  at the synapse (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209973", "l": "Tyrosine is diiodinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37359", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172678", "l": "PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45870", "l": "4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA => 9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204863", "l": "Interaction of Tie2 with Ang2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9844955", "l": "CLN3 transports GalCer to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610195", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2D (GRIN2D) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59515", "l": "acetylsalicylate + L-seryl-[protein] <=> O-acetyl-L-seryl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58701", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin => FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53555", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15949", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.98", "l": "\"(R)-2-hydroxy-fatty-acid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1011598", "l": "DOCKs bind to RhoGEFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34750", "l": "15-methylhexadecasphinganine + ATP <=> 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10980", "l": "L-serine = D-serine", "d": [], "t": []}, {"i": "EC:5.1.1.18", "l": "\"serine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55192", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 = 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102443", "l": "L-2-hydroxycarboxylate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate = NADH(2-) + H+ + a 2-oxo carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12319", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56100", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) = [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.100", "l": "\"SAMP-activating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36854", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56771", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 <=> 2 A + all-trans-adonixanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62571", "l": "H2O + S-benzyl-L-cysteinylglycine <=> glycine + S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58851", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-hydroxygeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754964", "l": "ADA deamidates RBV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220612", "l": "Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34029", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956676", "l": "YAP1 binds TP73 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40409", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658574", "l": "PARK2 binds SNCAIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45516", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59427", "l": "benzylamine + H2O + O2 <=> benzaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14500", "l": "A + pyridoxine <=> AH2 + isopyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754129", "l": "CDK6 inhibitors bind CDK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71314", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) <=> chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77507", "l": "(E)-cinnamaldehyde + hydrogen cyanide = (2S,3E)-2-hydroxy-4-phenylbut-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13734", "l": "an n-alkanal + NAD(+) => an alk-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31971", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.146", "l": "\"taxoid 14beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004802", "l": "transketolase activity", "d": ["Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51826", "l": "AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34683", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O = alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.63", "l": "\"alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.13", "l": "\"iduronate-2-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380930", "l": "Phosphorylated AMPK binds AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11615", "l": "H2O + L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:1902944", "l": "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "d": ["Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34328", "l": "4-nitrophenol + H(+) + NADPH + O2 => 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33950", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine <=> 2'-N-acetylparomamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16095", "l": "(24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678925", "l": "NR3C1 binds NR3C1 agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140814", "l": "glycine betaine:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in)."], "t": []}, {"i": "RHEA:71175", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) = 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64837", "l": "2-phenylethanol + acetyl-CoA => CoA + phenethyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420121", "l": "SFKs phosphorylate PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48774", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + H2O => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34806", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010328", "l": "auxin influx transmembrane transporter activity", "d": ["Enables the transfer of auxin, from one side of a membrane to the other, into a cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210805", "l": "Removal of miRNA passenger strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044323", "l": "retinoic acid-responsive element binding", "d": ["Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050605", "l": "superoxide reductase activity", "d": ["Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61072", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA = (-)-(R)-19-O-acetyltabersonine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021357", "l": "PRKCI phosphorylates ELF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047867", "l": "dimethylmalate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509827", "l": "ITPA hydrolyses ITP to IMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71777", "l": "acetoacetate(in) + H(+)(in) => acetoacetate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674140", "l": "PAQR3 binds inactive RAFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374701", "l": "Phosphorylation of DCC by Fyn (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48537", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O => 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43599", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008881", "l": "glutamate racemase activity", "d": ["Catalysis of the reaction: L-glutamate = D-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251992", "l": "Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10578", "l": "CDP-N-methylethanolamine + diphosphate => CTP + H(+) + N-methylethanolamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25882", "l": "2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+) => 2 L-dopa + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429694", "l": "CERT1-2 complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112690", "l": "PTPN11 binds CBL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796048", "l": "AcK-NFE2L2 binds the ABCG2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026579", "l": "NTRK2 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64334", "l": "AMP + diphosphate + nicotinyl-CoA => ATP + CoA + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38360", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 => thiosulfate + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21804", "l": "ATP + myo-inositol = 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.64", "l": "\"inositol 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707516", "l": "FeHM dissociates from MetHb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61922", "l": "(2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate => (2R,4S)-ketoconazole(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50152", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53423", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine <=> H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46251", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46724", "l": "(2S)-2-methyltetradecanoyl-CoA = (2R)-2-methyltetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390641", "l": "ADRA1A,B,D bind ADR,NAd (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653957", "l": "Rag dimer formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11516", "l": "H2O + succinyl-CoA = CoA + H(+) + succinate", "d": [], "t": []}, {"i": "EC:3.1.2.3", "l": "\"succinyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62363", "l": "FMN-N(5)-peroxide + uracil <=> (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69899", "l": "2 Na(+)(out) + thymidine(out) = 2 Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018794", "l": "RHOV binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71308", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) => chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61528", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15254", "l": "cis-aconitate + H(+) => CO2 + itaconate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64298", "l": "(4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+) => (4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14884", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) <=> asparagusate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52787", "l": "2-sulfenohercynine + AH2 + H(+) <=> A + ergothioneine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70645", "l": "D-proline(in) + H(+)(in) => D-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51261", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29543", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.256", "l": "\"dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48669", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449855", "l": "IL10 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419490", "l": "Binding of ATP to P2X receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66031", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine <=> (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68770", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine => 4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11378", "l": "4,21-dehydrogeissoschizine + NADPH => (19E)-geissoschizine + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939201", "l": "ESR dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687625", "l": "ATP binds MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757574", "l": "ALB binds PREDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40340", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750666", "l": "ALB binds ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805061", "l": "CK2 binds FACT (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76201", "l": "oxalate(out) => oxalate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.37", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75931", "l": "H2O + taurocyamine = taurine + urea", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75370", "l": "cytidine(in) <=> cytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.61", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20111", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ADP => alpha-D-ribose 1,5-bisphosphate + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31258", "l": "(2S)-2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25951", "l": "a 1,2-diacyl-sn-glycerol + CTP <=> a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702818", "l": "CALCR binds erenumab (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052734", "l": "shikimate 3-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36305", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a fatty acyl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68272", "l": "a fatty acyl-CoA + L-seryl-[protein] = CoA + O-fatty acyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61391", "l": "ATP + biotin(in) + H2O <=> ADP + biotin(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018794", "l": "RHOV binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35168", "l": "minocycline(in) => minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17802", "l": "acetyl-CoA + L-phenylalanine => CoA + H(+) + N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28611", "l": "H2O + XTP => diphosphate + H(+) + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39694", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH <=> (11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59858", "l": "methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine => Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67610", "l": "diphosphate + H(+) + N(6)-methyl-AMP => H2O + N(6)-methyl-ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785565", "l": "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74816", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23482", "l": "dimethylmaleate => 2-methylene-3-methylsuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33310", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] <=> (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944214", "l": "Association of procollagen type I (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61349", "l": "ATP + estrone 3-sulfate(in) + H2O => ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47526", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => cholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654511", "l": "FGFRL1 dimer binds FGFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69532", "l": "(2S)-2-amino-4-deoxychorismate = 4-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58531", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77538", "l": "H2O + L-methionyl-tRNA(Leu) <=> H(+) + L-methionine + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086039", "l": "P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24690", "l": "acetate + eugenol + NADP(+) = (E)-coniferyl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47836", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP = [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.31", "l": "\"[5-(aminomethyl)furan-3-yl]methyl phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-532549", "l": "MPI isomerises Fru6P to Man6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14223", "l": "H(+) + methanol + sulfate => H2O + monomethyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653724", "l": "Transcription of ATF5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43822", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31699", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": [], "t": []}, {"i": "EC:1.14.15.32", "l": "\"pentalenene oxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69078", "l": "(R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) => (R)-noradrenaline + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60150", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675194", "l": "Activated MAPK phosphorylates RAF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40017", "l": "13-epi-manool + diphosphate => (+)-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15618", "l": "Fe(3+) + Fe(II)-[cytochrome c] => Fe(2+) + Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44336", "l": "an L-alpha-amino acid + ATP + L-arginine = ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.48", "l": "\"L-arginine-specific L-amino acid ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10997", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine => 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.74", "l": "\"chalcone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76699", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29015", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) = phosphate(in) + sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68692", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) = 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18720", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76499", "l": "N-acetyl-D-glutamate = N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75172", "l": "Formation of RAD50:MRE11 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29748", "l": "3-phenylpropanoate(in) => 3-phenylpropanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15210", "l": "(2R,3R)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18612", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine <=> H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44171", "l": "dodecanoate + 2 H(+) + NADH <=> dodecanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876258", "l": "CBL monoubiquitinates InlB-bound MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382096", "l": "Formation of NR-NCOR Corepressor Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169719", "l": "Secreted CD14 binds LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11799", "l": "ecdysone + O2 <=> 3-dehydroecdysone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61271", "l": "H2O + L-2-aminohexanoate + O2 <=> 2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035497", "l": "cAMP response element binding", "d": ["Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759334", "l": "NFE2L2 binds the SRXN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73676", "l": "ADP(out) + dAMP(in) + H(+)(out) => ADP(in) + dAMP(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13220", "l": "H2O + NAD(+) + succinate semialdehyde <=> 2 H(+) + NADH + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110319", "l": "Elongation by POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.158", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56786", "l": "(6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71870", "l": "glycodeoxycholate(out) <=> glycodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58471", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31355", "l": "dimethyl sulfide + H(+) + NADH + O2 = formaldehyde + H2O + methanethiol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.131", "l": "\"dissimilatory dimethyl-sulfide monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48985", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49997", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005115", "l": "receptor tyrosine kinase-like orphan receptor binding", "d": ["Binding to a receptor tyrosine kinase-like orphan receptor (Ror)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42877", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51406", "l": "5-guanidino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853801", "l": "PSPN binds RET:GFRA4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22118", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP => luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70309", "l": "cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine => beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59014", "l": "24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18879", "l": "1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68873", "l": "(E)-cinnamate + ATP + H(+) + NADPH => (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37298", "l": "ATP + H2O + L-alanyl-L-threonine(out) <=> ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40069", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033840", "l": "NDP-glucose-starch glucosyltransferase activity", "d": ["Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046863", "l": "ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity", "d": ["Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57543", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.14", "l": "\"oleoyl-[acyl-carrier-protein] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050024", "l": "L-galactonolactone oxidase activity", "d": ["Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638006", "l": "ARL3 hydrolyzes GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69425", "l": "2-hydroxyisobutanoyl-CoA => acetone + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18385", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate = acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.302", "l": "\"2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718379", "l": "GNRHR binds chemical antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156678", "l": "Activation of Cdc25C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.490346476819873", "identifiers": [{"i": "GO:0016835", "l": "carbon-oxygen lyase activity", "d": ["Catalysis of the breakage of a carbon-oxygen bond."], "t": []}, {"i": "EC:4.2.-.-", "l": "\"Carbon-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176445", "l": "SMURF2 binds SMAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357432", "l": "AXL binds SRC-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.74", "l": "\"cutinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31586", "l": "2-oxo-dATP + H2O <=> 2-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74986", "l": "Elongation of pre-rRNA transcript (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52033", "l": "H2O + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57875", "l": "(E)-2,4-dihydroxycinnamoyl-CoA <=> CoA + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17123", "l": "H(+) + L-homocitrulline + phosphate => carbamoyl phosphate + L-lysine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112514", "l": "JAK activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127562", "l": "STRAP binds phosphorylated TGF-beta receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18694", "l": "a penicillin + H2O => 6-aminopenicillanate + a carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18380", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 3''-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20050", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26008", "l": "beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP => di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050263", "l": "ribosylpyrimidine nucleosidase activity", "d": ["Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20077", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.34", "l": "\"tRNA (guanosine(18)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55208", "l": "(4R)-hydroxysphinganine 1-phosphate = (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41703", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082391", "l": "Trimerization of HSF1 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693929", "l": "RIPK1 variant is not cleaved by CASP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48945", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74737", "l": "7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66532", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19638", "l": "D-nopaline + H2O + NADP(+) => 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168412", "l": "MDP elicits a NOD2 response (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72397", "l": "2 chloride(in) + K(+)(in) + Na(+)(in) => 2 chloride(out) + K(+)(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852010", "l": "BTNL2 binds activated T cells surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030331", "l": "nuclear estrogen receptor binding", "d": ["Binding to a nuclear estrogen receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73111", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether = ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559468", "l": "TLR1/2 ligand binds to CD14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13917", "l": "(-)-menthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.207", "l": "\"(-)-menthol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462014", "l": "Alpha-defensins form biologically active dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38323", "l": "2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45708", "l": "3-dehydrocarnitine + acetyl-CoA = 3-dehydrocarnityl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199112", "l": "CRTAM binds to NECL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51470", "l": "a quinol + pyruvate => (R)-lactate + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44364", "l": "2-epi-5-epi-valiolone + ATP = 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.188", "l": "\"2-epi-5-epi-valiolone 7-kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51682", "l": "(2E,6E)-farnesyl phosphate + CDP + H(+) => (2E,6E)-farnesol + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75262", "l": "isoorientin + O2 <=> 3'-dehydroisoorientin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41794", "l": "CoA + malonyl-[ACP] => holo-[ACP] + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10264", "l": "alpha-D-glucose = beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10749", "l": "H(+) + hydrogencarbonate => CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47823", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70784", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) => H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202241", "l": "Recruitment of SLP-76 to Gads (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696465", "l": "USP45 deubiquitinates ERCC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42600", "l": "AH2 + prostaglandin G2 = A + H2O + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160915", "l": "Receptor-mediated uptake of HA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624956", "l": "PDE6D binds INPP5E (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033926", "l": "glycopeptide alpha-N-acetylgalactosaminidase activity", "d": ["Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60938", "l": "an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35007", "l": "D-fucose(in) = D-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45331", "l": "7,8-dihydroneopterin <=> 7,8-dihydromonapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640862", "l": "Tankyrase binds AXIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0099099", "l": "G-protein gated monoatomic ion channel activity", "d": ["An ion channel activity that is gated by binding of a G-protein beta-gamma dimer."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59715", "l": "D-maltotetraono-1,5-lactone + H2O <=> D-maltotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75487", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) = dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35655", "l": "2 ATP = 3',3'-c-di-AMP + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.85", "l": "\"diadenylate cyclase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.52", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56773", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 => 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15195", "l": "2'-deoxyguanosine + H(+) + triphosphate => dGTP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71773", "l": "2 Cu(2+) + NADPH => 2 Cu(+) + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22744", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.62", "l": "\"mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23904", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}, {"i": "EC:2.3.2.2", "l": "\"gamma-glutamyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66014", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14416", "l": "biphenyl-2,3-diol + O2 <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692749", "l": "CDC14A,B bind MAPK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36667", "l": "(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442749", "l": "CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210274", "l": "SIRP beta binds TYROBP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39739", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 = 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219524", "l": "PDPK1 binds PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32210", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate <=> (3Z)-2-oxohex-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35548", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67597", "l": "heptadecasphing-4-enine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018785", "l": "RHOBTB2 binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16248", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050536", "l": "(S)-N-acetyl-1-phenylethylamine hydrolase activity", "d": ["Catalysis of the reaction: N-acetylphenylethylamine + H2O = acetate + phenylethylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63421", "l": "2-hydroxyethylphosphonate + CTP => cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23712", "l": "NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al", "d": [], "t": []}, {"i": "EC:1.1.1.151", "l": "\"21-hydroxysteroid dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13291", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75876", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0050738", "l": "fructosyltransferase activity", "d": ["Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70414", "l": "4-hydroxyphenylacetyl-CoA + H2O <=> 4-hydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663426", "l": "sCD163 binds MYH9 in T-cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15277", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": [], "t": []}, {"i": "EC:2.3.1.108", "l": "\"alpha-tubulin N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981606", "l": "Myoglobin binds oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64281", "l": "(S)-1-phenylethylamine + pyruvate => acetophenone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50944", "l": "3-phenylpropanoate + NAD(+) = (E)-cinnamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42831", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694592", "l": "3CLp dimer binds 3CLp inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654163", "l": "Activated FGFR4 binds PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62723", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I <=> betaenone B + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140900", "l": "chloride:bicarbonate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102947", "l": "(+)-delta-cadinene-8-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 = 8-hydroxy-(+)-delta-cadinene + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58612", "l": "2 L-ascorbate + N-octanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77629", "l": "1-O-alkyl-3-acylglycerol + CoA => 1-O-alkylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937079", "l": "MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57704", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19048", "l": "acetyl-CoA + H2O + pyruvate <=> (3R)-citramalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54041", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65440", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14242", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA => 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030294", "l": "receptor signaling protein tyrosine kinase inhibitor activity", "d": ["Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59659", "l": "D-cellotriose + O2 <=> D-cellotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22292", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA = biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.177", "l": "\"3,5-dihydroxybiphenyl synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052927", "l": "CTP:tRNA cytidylyltransferase activity", "d": ["Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' CC end + 2 diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46418", "l": "(6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63171", "l": "fumarate + L-cysteine <=> S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47551", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate <=> 3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.7", "l": "\"glutamyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22644", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] = 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.98", "l": "\"protopine 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102123", "l": "gibberellin A4 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H = 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003987", "l": "acetate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77420", "l": "(E)-hex-2-enal + hydrogen cyanide => (2S,3E)-2-hydroxyhept-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177934", "l": "EGFR autophosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10661", "l": "L-seryl-[protein] => D-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21315", "l": "2,5-dihydroxybenzoate + H(+) <=> CO2 + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395992", "l": "p-T,4S-IRF3 is dimerized (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.19.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68909", "l": "ATP + H(+) + NADPH + picolinate => AMP + diphosphate + NADP(+) + picolinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28468", "l": "pyridoxamine(out) => pyridoxamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773208", "l": "CDH19 gene expression is stimulated by SOX10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964496", "l": "STING binds TRIM32 or TRIM56  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46678", "l": "(6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH => (4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351901", "l": "Caspase-mediated cleavage of MST3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205289", "l": "Autophosphorylation of KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110319", "l": "Elongation by POLH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844447", "l": "NLRP1 senses MDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20515", "l": "2-arylpropionate + CO2 => 2-aryl-2-methylmalonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051575", "l": "5'-deoxyribose-5-phosphate lyase activity", "d": ["Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74721", "l": "7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10845", "l": "oxaloacetate + pyridoxamine => L-aspartate + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21039", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046509", "l": "1,2-diacylglycerol 3-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30480", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28136", "l": "(2S)-hesperetin + rutinose => (2S)-hesperidin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14077", "l": "3-oxopropanoate + L-alanine = beta-alanine + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.18", "l": "\"beta-alanine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33237", "l": "3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+) => 2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696267", "l": "RND3 binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67790", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin => 2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158399", "l": "kallikrein binds SERPING1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33517", "l": "2 H2O + 2 indole-5,6-quinone => 2 5,6-dihydroxyindole + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490269", "l": "AFXBO-C, AFNBO-C translocate from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33783", "l": "1(F)-beta-D-fructosylsucrose + sucrose = 1,6-kestotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63767", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37958", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807008", "l": "PTPRJ dephosphorylates MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70539", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098770", "l": "FBXO family protein binding", "d": ["Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983147", "l": "Release of E3 from polyubiquitinated substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32033", "l": "diphosphate + gamma-curcumene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43686", "l": "AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045503", "l": "dynein light chain binding", "d": ["Binding to a light chain of the dynein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877187", "l": "P2X7 mediates loss of intracellular K+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72691", "l": "Formation of the 43S pre-initiation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46070", "l": "(2E)-nonenoyl-CoA => (3E)-nonenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33765", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a (2E)-enoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17080", "l": "H2O + N,N-dimethylglycine + O2 <=> formaldehyde + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51239", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57212", "l": "dGTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050058", "l": "linoleate isomerase activity", "d": ["Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21590", "l": "H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH => N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56480", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54161", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 => [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62432", "l": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70258", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52709", "l": "GMP + H2O => D-ribose 5-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.205", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669158", "l": "NF2 binds PAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858482", "l": "DVL is recruited to the receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0140824", "l": "thioredoxin-dependent peroxiredoxin activity", "d": ["Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22674", "l": "diphosphate + presqualene diphosphate => 2 (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40713", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate => 1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47151", "l": "a ubiquinone + caffeine + H2O <=> 1,3,7-trimethylurate + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55595", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O <=> (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192781", "l": "Viral mRNA Splicing (M, NS segments) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77094", "l": "Formation of cap binding complex (CBC) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944454", "l": "mTORC1 phosphorylates MAF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033411", "l": "UAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72048", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline => AH2 + fusahexin + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48874", "l": "a gentamycin 2''-phosphate + GDP + H(+) => a gentamycin + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449077", "l": "Interleukin-16 is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50973", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950213", "l": "Expression of Phosphatidylinositol transfer protein alpha isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018535", "l": "nicotine dehydrogenase activity", "d": ["Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31202", "l": "(3S)-hydroxyoctanoyl-CoA <=> (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429714", "l": "CSNK1G2 phosphorylates p-CERT1-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45886", "l": "4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620975", "l": "MLKL binds PIPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38084", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106411", "l": "XMP 5'-nucleosidase activity", "d": ["Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.-", "l": "\"Miscellaneous\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29073", "l": "a ubiquinol + CO2 => a ubiquinone + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71058", "l": "L-cysteine(out) + L-methionine(in) <=> L-cysteine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56282", "l": "AMP + L-prolyl-[peptidyl-carrier protein] => 3'-L-prolyl-AMP + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2471842", "l": "Collagen type XXV ectomain shedding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400256", "l": "CRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39495", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389972", "l": "alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64615", "l": "ATP + L-glutamate + tRNA(Gln) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.201", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051742", "l": "2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043914", "l": "NADPH:sulfur oxidoreductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+."], "t": []}, {"i": "EC:1.8.1.18", "l": "\"NAD(P)H sulfur oxidoreductase (CoA-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710354", "l": "GSDME (1-270) binds cardiolipin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28316", "l": "baicalin + UDP => baicalein + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14168", "l": "acetyl-CoA + L-aspartate <=> CoA + H(+) + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801109", "l": "CHM binds RGGT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36636", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22426", "l": "an alkyl thiol + NH4(+) + pyruvate => an S-alkyl-L-cysteine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008036", "l": "RUNX2 binds to HIVEP3 and WWP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63829", "l": "L-alanine + vanillin => pyruvate + vanillylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29264", "l": "L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.69", "l": "\"gluconate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061653", "l": "ISG15 conjugating enzyme activity", "d": ["Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19635", "l": "(5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+) => (3S,5S)-3,5-diaminohexanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22106", "l": "3''-deamino-3''-oxonicotianamine + L-glutamate => 2-oxoglutarate + nicotianamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20446", "l": "L-arogenate + oxaloacetate => L-aspartate + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53153", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56238", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72368", "l": "estrone 3-sulfate(out) + succinate(in) => estrone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62921", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol => 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0009486", "l": "cytochrome bo3 ubiquinol oxidase activity", "d": ["Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19615", "l": "S-adenosyl-L-homocysteine + trimethylsulfonium => dimethyl sulfide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26132", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607721", "l": "Activation of NIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74683", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140340", "l": "cerebroside transfer activity", "d": ["Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73122", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52673", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50657", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008261", "l": "allatostatin receptor activity", "d": ["Combining with allatostatin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691421", "l": "BTK binds BTK inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54184", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37909", "l": "(8E,10S)-10-hydroperoxy-octadeca-8-enoate => (9Z)-octadecenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22695", "l": "3-hydroxybenzoate + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046567", "l": "aphidicolan-16 beta-ol synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39353", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20534", "l": "H2O + pyridoxal 5'-phosphate => phosphate + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72691", "l": "Formation of the 43S pre-initiation complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45649", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432825", "l": "HMGB1 binds TLR4:LY96 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782943", "l": "UV-DDB ubiquitinates XPC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58673", "l": "D-glucuronate => aldehydo-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015516", "l": "tartrate:succinate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019770", "l": "IgG receptor activity", "d": ["Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56793", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912429", "l": "Resolution of meiotic holliday junction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32118", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 <=> CO2 + succinate + TRIBOA beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12510", "l": "loganin + S-adenosyl-L-homocysteine => loganate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74906", "l": "(2E)-2-butenoate + ATP + H(+) <=> (2E)-but-2-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102391", "l": "decanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67060", "l": "asnovolin I + S-adenosyl-L-methionine = asnovolin K + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836270", "l": "TFAP2A binds TFAP2C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.15", "l": "\"thimet oligopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38860", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64166", "l": "formaldehyde + L-alanine => 2-methyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706399", "l": "RHOBTB3 hydrolyzes ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.152", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694433", "l": "MIA2 binds PREB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23235", "l": "4 Fe(III)-[cytochrome c] + hydrazine <=> 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43191", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA <=> H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62273", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28053", "l": "H2O + NADP(+) <=> NAD(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247960", "l": "Activation of p38 MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74762", "l": "isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72040", "l": "nicotinate(in) + orotate(out) => nicotinate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35738", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15235", "l": "Fe(II)-[cytochrome c] + 2 H(+) + nitrite => Fe(III)-[cytochrome c] + H2O + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.153", "l": "\"fructan beta-(2,1)-fructosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74809", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868071", "l": "Clathrin recruits PIK3C2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396009", "l": "STING binds c-di-GMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16584", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 <=> 2 Fe(III)-[cytochrome c] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31103", "l": "7,8-dihydrofolate + NADP(+) = folate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051669", "l": "fructan beta-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879909", "l": "Activation of STAT5a/b by JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13252", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13679", "l": "D-xylulose 5-phosphate => D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199046", "l": "Ligands bind L-selectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39685", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+) => 3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018711", "l": "benzoyl acetate-CoA thiolase activity", "d": ["Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57694", "l": "2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18137", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.278", "l": "\"3beta-hydroxy-5alpha-steroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975134", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40751", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157145", "l": "NOTCH3 binds DLL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202459", "l": "Phosphorylation of Bcl10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229181", "l": "CALM1:Ca2+ binds CNG channel (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42571", "l": "2,3-dihydroxy-p-cumate + O2 <=> 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031802", "l": "Maresins translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252001", "l": "ATP1B4 binds SNW1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53281", "l": "D-threose => D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26550", "l": "(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63297", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45351", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53996", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58466", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP => a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66885", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109702", "l": "PDPK1 phosphorylates AKT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.6", "l": "\"aminopeptidase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19548", "l": "H2O + sn-glycerol 3-phosphocholine <=> glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620004", "l": "RSKs autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22847", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102751", "l": "UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254291", "l": "ERBB4s80 binds STAT5A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855047", "l": "Hydrolysis of internal thioester in C4b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76134", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) <=> 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54925", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682388", "l": "Autophagosome maturation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66036", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24798", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => (S)-2-amino-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.12", "l": "\"acyl-lipid omega-(9-4) desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32154", "l": "9alpha-copalyl diphosphate <=> (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689085", "l": "ATXN3 binds polyUb-PARK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11660", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": [], "t": []}, {"i": "EC:3.5.1.89", "l": "\"N-acetylglucosaminylphosphatidylinositol deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34366", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199404", "l": "CD40L binds CD40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28047", "l": "phosphate + propanoyl-CoA => CoA + propanoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218832", "l": "CDC42:GTP binds PAK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110322", "l": "Formation of Pol zeta complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015544", "l": "phenyl propionate uniporter activity", "d": ["Enables the transfer of phenyl propionate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54456", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44896", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42511", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) <=> 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51247", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27698", "l": "GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964280", "l": "Active Gq binds BTK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60440", "l": "H2O + methyl acetate = acetate + H(+) + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.114", "l": "\"methyl acetate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354097", "l": "Activation of Talin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60342", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201521", "l": "ALK autophosphorylation  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102177", "l": "24-methylenelophenol methyl oxidase activity", "d": ["Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ = 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74844", "l": "3'-phosphoadenylyl sulfate + a ganglioside GM1b => adenosine 3',5'-bisphosphate + an 8-O-sulfo-ganglioside GM1b + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000297", "l": "spermine transmembrane transporter activity", "d": ["Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75831", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19633", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) = (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.11", "l": "\"L-erythro-3,5-diaminohexanoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016416", "l": "O-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34512", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48138", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate => a ganglioside GM3 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63299", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.105", "l": "\"L-tryptophan decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19088", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41106", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168640", "l": "Ubiquitinated IkB is degraded (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247497", "l": "ERBB3 binds neuregulins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036082", "l": "extracellular phenylacetaldehyde-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone = 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211191", "l": "Association of DFF with alpha:beta importin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51282", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43512", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 = 2-carboxy-5-formylfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12384", "l": "5,6-dihydrouracil + O2 = H2O2 + uracil", "d": [], "t": []}, {"i": "EC:1.3.3.7", "l": "\"dihydrouracil oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61326", "l": "3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43874", "l": "3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate => 3-oxochol-4-en-22-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75685", "l": "(12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate => (12R,13S)-epoxy-(9Z)-octadecenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35863", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59256", "l": "Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11745", "l": "H2O + thiamine triphosphate => H(+) + phosphate + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12461", "l": "(S)-malate => fumarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10146", "l": "a ribonucleoside + phosphate => a ribonucleoside 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209925", "l": "DIT and MIT combine to form triiodothyronine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15978", "l": "(S)-4-hydroxymandelonitrile => 4-hydroxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.37", "l": "\"acyl-CoA 5-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13353", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.14", "l": "\"CDP-ribitol ribitolphosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71970", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791066", "l": "Expression of HYOU1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28165", "l": "cytidine + GTP <=> CMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54033", "l": "(6R)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49961", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 => 5,10-dihydrophenazine + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12908", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) <=> GDP-alpha-D-mannose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59106", "l": "a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+) => a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56014", "l": "beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25855", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139918", "l": "Phosphorylation of BIM by JNK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27992", "l": "1-deoxy-D-xylulose 5-phosphate + ADP + H(+) => 1-deoxy-D-xylulose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70017", "l": "7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24548", "l": "an N(6)-acyl-L-lysine + H2O = a carboxylate + L-lysine", "d": [], "t": []}, {"i": "EC:3.5.1.17", "l": "\"acyl-lysine deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399938", "l": "Activation of Rac1 by FARP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801675", "l": "PLK2 phosphorylates NPM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59517", "l": "acetylsalicylate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76333", "l": "L-aspartate(out) + L-tyrosine(in) => L-aspartate(in) + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57265", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13466", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA => CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34776", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) => a 3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189488", "l": "UROS transforms HMB to URO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24602", "l": "H2O2 + sulfate => H2O + O2 + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56242", "l": "2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein] => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19441", "l": "benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23406", "l": "diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12584", "l": "16alpha-hydroxyprogesterone = 16,17-didehydroprogesterone + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.98", "l": "\"16alpha-hydroxyprogesterone dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0003730", "l": "mRNA 3'-UTR binding", "d": ["Binding to a 3' untranslated region of an mRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46489", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373734", "l": "Nephrin interacts with Podocin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247513", "l": "STAB1:ligand is endocytosed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34094", "l": "(5R)-5-phosphooxy-L-lysine + H2O <=> (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35754", "l": "ATP + kanosamine <=> ADP + D-kanosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16859", "l": "an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617815", "l": "BBSome binds RAB3IP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59219", "l": "(indol-3-yl)acetate + H(+) <=> CO2 + skatole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19793", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.5.8.3", "l": "\"sarcosine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653514", "l": "USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25782", "l": "3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39582", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36023", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49200", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.132", "l": "\"3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38632", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877918", "l": "RUNX2:MAF complex binds the BGLAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033425", "l": "CAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19842", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855164", "l": "IP6 transports from the cytosol to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052830", "l": "inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60759", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone <=> cinerin I + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15649", "l": "carbamate + 2 H(+) = CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731075", "l": "Syndecan-1 binds collagen types I, III, V (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62898", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46177", "l": "2-methylpropanoate + ATP + CoA => 2-methylpropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376419", "l": "Formation of NR-MED1 Coactivator Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28241", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25068", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17906", "l": "(R)-glycerate + NAD(+) => 3-hydroxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448741", "l": "IL22RA2 binds IL22 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55922", "l": "(4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3) => [cis-1,4-isoprene](n) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72528", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005459", "l": "UDP-galactose transmembrane transporter activity", "d": ["Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20707", "l": "a D-alpha-amino acid + acetyl-CoA <=> an N-acetyl-D-amino acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140393", "l": "norsolorinic acid ketoreductase activity", "d": ["Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374298", "l": "Opioid receptors bind opioid peptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008744", "l": "L-xylulokinase activity", "d": ["Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57973", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944266", "l": "Association of procollagen type XI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174493", "l": "Glycosylation of ENV polyprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22619", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2R)-bisdechlorogeodin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917700", "l": "MVB Vesicle Formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73713", "l": "ATP(out) + UTP(in) => ATP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38623", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19075", "l": "ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein] => ATP + L-seryl-[I-kappa-B protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36833", "l": "2 caldariellaquinone + n H(+)(out) + 2 H2O => 2 caldariellaquinol + n H(+)(in) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16001", "l": "H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43764", "l": "ATP + chenodeoxycholate + CoA = AMP + chenodeoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69691", "l": "a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine = a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801101", "l": "RABGGTA binds RABGGTB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36132", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine => methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140768", "l": "protein ADP-ribosyltransferase-substrate adaptor activity", "d": ["An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418200", "l": "SRC-1 bound to ARRB2 is not activated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209828", "l": "Tryptophan is hydroxylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61401", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12352", "l": "L-gulono-1,4-lactone + O2 = H2O2 + L-xylo-hex-3-ulonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26435", "l": "indole + L-serine => H2O + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48902", "l": "3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35463", "l": "lathosterol + NAD(+) = 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019116", "l": "hydroxy-nicotine oxidase activity", "d": ["Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047788", "l": "2-coumarate reductase activity", "d": ["Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = trans-2-coumarate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209738", "l": "VD3 binds GC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029476", "l": "Role of myosins in phagosome formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50592", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24288", "l": "5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": [], "t": []}, {"i": "EC:2.1.2.4", "l": "\"glycine formimidoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66175", "l": "H(+)(out) + L-cystine(out) <=> H(+)(in) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870466", "l": "RGGT:CHM binds RABs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12337", "l": "carboxymethoxysuccinate => fumarate + glycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42989", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cembrene C + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726580", "l": "PGR binds PGR agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69430", "l": "arsenic triglutathione + 3 H2O => arsenite + 3 glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202203", "l": "Recruitment of PI3K to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47277", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36386", "l": "carbamoyl adenylate + tobramycin <=> AMP + H(+) + nebramycin 5'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26562", "l": "2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.1.3.36", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691174", "l": "RAC1 binds effectors at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27659", "l": "2-deoxy-alpha-D-ribose 1-phosphate => 2-deoxy-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24230", "l": "4-methylcatechol + CO2 + NADH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53681", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10014", "l": "6-hydroxypseudooxynicotine + H2O2 => (R)-6-hydroxynicotine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734687", "l": "ORC6 is phosphorylated on T195 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34348", "l": "(2E)-geraniol + NAD(+) => (2E)-geranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64415", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003942", "l": "N-acetyl-gamma-glutamyl-phosphate reductase activity", "d": ["Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698003", "l": "FLT3 mutants phosphorylate GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66019", "l": "bromide + H2O2 <=> H2O + hypobromite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227732", "l": "IPS1 interacts with TRADD, RIP1 and FADD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47150", "l": "1,3,7-trimethylurate + a ubiquinol => a ubiquinone + caffeine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454916", "l": "The ABCC family mediates organic anion transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20626", "l": "2 Fe(III)-[cytochrome c3] + H2 => 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944263", "l": "Association of procollagen type II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57608", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-chlorocatechol + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.119", "l": "\"chlorobenzene dihydrodiol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785244", "l": "Defective CYP11B2 does not oxidise 18HCORST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9612219", "l": "ERBB4s80 binds to SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65965", "l": "ATP + H2O + taurocholate(out) => ADP + H(+) + phosphate + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733545", "l": "Bile salts and acids bind ALB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17288", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061749", "l": "forked DNA-dependent helicase activity", "d": ["Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62532", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196417", "l": "Reduction of desmosterol to cholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43958", "l": "H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate => 15-methylhexadecanoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879910", "l": "JAK2 is phosphorylated, activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25571", "l": "ATP + beta-D-ribosylnicotinate <=> ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0016759", "l": "cellulose synthase activity", "d": ["Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29887", "l": "ATP + H2O + L-lysine(out) = ADP + H(+) + L-lysine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49894", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65741", "l": "2-oxoglutarate + nonyl sufate + O2 => CO2 + H(+) + nonanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56084", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O = [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191654", "l": "c-src associates with Cx43 in gap junctions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047444", "l": "N-acylneuraminate-9-phosphate synthase activity", "d": ["Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16629", "l": "(S)-malyl-CoA = acetyl-CoA + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202960", "l": "Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21204", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": [], "t": []}, {"i": "EC:2.3.1.43", "l": "\"phosphatidylcholine--sterol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18710", "l": "A + H2O + taurine => AH2 + NH4(+) + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41982", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58964", "l": "H2O + hexanal + O2 = H(+) + H2O2 + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012671", "l": "p-STAT5 binds CISH, SOCS1 and SOCS2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66053", "l": "indole-3-pyruvate + L-kynurenine => H2O + kynurenate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655341", "l": "Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22374", "l": "3-oxopropanoate + H(+) + H2O2 + nitrite => H2O + O2 + propionate 3-nitronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38196", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57902", "l": "adenosine in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54514", "l": "(13R)-9,13-epoxylabd-14-ene + diphosphate => peregrinol diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043881", "l": "mesaconyl-CoA hydratase activity", "d": ["Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398040", "l": "Gbeta:gamma activation of PLC beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676160", "l": "AAMP binds NOD2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25062", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23243", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41531", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH <=> NAD(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000833", "l": "inositol heptakisphosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43589", "l": "a globoside NORint + UDP-alpha-D-galactose => a globoside NOR2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40822", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57601", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14637", "l": "3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": [], "t": []}, {"i": "EC:2.8.2.16", "l": "\"thiol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0031955", "l": "short-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons."], "t": []}, {"i": "RHEA:52860", "l": "a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59605", "l": "H2O + O2 + spermidine => H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10214", "l": "5-oxopentanoate + L-glutamate => 2-oxoglutarate + 5-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050031", "l": "L-pipecolate oxidase activity", "d": ["Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983156", "l": "Polyubiquitination of substrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66286", "l": "H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP => tomatidine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49542", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24055", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77006", "l": "(4S)-4-hydroxy-L-arginine <=> H2O + L-enduracididine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22206", "l": "H2O + homogentisate + NADP(+) => 3-hydroxyphenylacetate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48307", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18126", "l": "A + a D-alpha-amino acid + H2O => a 2-oxocarboxylate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769397", "l": "SOST binds LRP5/6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11916", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635868", "l": "ub-GLI is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77605", "l": "3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol) => 2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047591", "l": "5-hydroxypentanoate CoA-transferase activity", "d": ["Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69507", "l": "N-acetyl-D-glucosamine + O2 <=> H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32678", "l": "alpha,alpha-trehalose + H2O <=> alpha-D-glucose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032184", "l": "SUMO polymer binding", "d": ["Binding to a polymer of the small ubiquitin-like protein SUMO."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19461", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17058", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24581", "l": "D-sorbitol 6-phosphate + H2O => D-sorbitol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37828", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0046992", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y."], "t": []}, {"i": "EC:1.21.-.-", "l": "\"Catalyzing the reaction X-H + Y-H = 'X-Y'\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027632", "l": "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32934", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol <=> a cardiolipin + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804100", "l": "HMGB1 binds LPS (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15639", "l": "[alginate](n+1) + GDP + H(+) => [alginate](n) + GDP-alpha-D-mannuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623240", "l": "FOXO1 binds PPARGC1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987223", "l": "IL10RB binds TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19790", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) => 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51123", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 <=> (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44606", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.47", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34621", "l": "1-deoxy-11beta-hydroxypentalenate + CO2 + succinate => 1-deoxypentalenate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854209", "l": "TBC1D10A binds JFC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68430", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone => lutein + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640063", "l": "Ca2+ binds KCNIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706393", "l": "RHOBTB3 binds ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62460", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.62", "l": "\"3,4-dihydroxybenzoate--[aryl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55233", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66485", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose => 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21623", "l": "FMNH2 + NAD(+) <=> FMN + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129357", "l": "Fibrillin C-terminal processing (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166387", "l": "The FA anion diffuses away laterally from UCP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097718", "l": "disordered domain specific binding", "d": ["Binding to a disordered domain of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34785", "l": "a 3-oxosteroid + H(+) + NADPH => a 3alpha-hydroxysteroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44521", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863494", "l": "ASICs bind STOML3, (STOM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57390", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250280", "l": "ROS oxidize thioredoxin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047892", "l": "flavone apiosyltransferase activity", "d": ["Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69788", "l": "(2-aminophenyl)succinate + succinyl-CoA => 3-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59009", "l": "H2O + O2 + salicylaldehyde => H(+) + H2O2 + salicylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421471", "l": "hydroxymethylbilane => uroporphyrinogen I + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203979", "l": "Coat Assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54065", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-cubebol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419166", "l": "GEFs activate RhoA,B,C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433456", "l": "Recruitment of STATs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33370", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48635", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25032", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64400", "l": "an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380170", "l": "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426223", "l": "Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73015", "l": "D-leucine(in) = D-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53348", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25460", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sibirene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66937", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate => avenanthramide C + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53430", "l": "a thymidine in DNA + S-methyl-L-cysteinyl-[protein] => a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706304", "l": "Active FLT3 binds to GRAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55151", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031708", "l": "endothelin B receptor binding", "d": ["Binding to an endothelin B receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50752", "l": "2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40186", "l": "O2 + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50338", "l": "H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35018", "l": "riboflavin(in) <=> riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357432", "l": "AXL binds SRC-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51278", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43281", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43119", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39437", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663511", "l": "BIL binds GSTA1, FABP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28788", "l": "4-hydroxy-L-threonine + ATP => 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39251", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH = (11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391372", "l": "GNRHR binds GNRH1,2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483174", "l": "PE is methylated to PC by PEMT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20766", "l": "oxaloacetate + propanoyl-CoA => (S)-methylmalonyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77510", "l": "(E)-cinnamaldehyde + hydrogen cyanide <=> (2S,3E)-2-hydroxy-4-phenylbut-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58029", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH => a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24058", "l": "myo-inositol + phosphate => a myo-inositol phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17967", "l": "(8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10060", "l": "acetyl-CoA + D-tryptophan = CoA + H(+) + N-acetyl-D-tryptophan", "d": [], "t": []}, {"i": "EC:2.3.1.34", "l": "\"D-tryptophan N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24398", "l": "1,3,8-trihydroxynaphthalene + H2O => scytalone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76688", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione => (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61784", "l": "L-allulose = keto-L-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247922", "l": "GGCT transforms gGluCys to OPRO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672951", "l": "Inactive RAFs bind YWHAB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.94", "l": "\"versiconal hemiacetal acetate esterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299481", "l": "TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062046", "l": "dehydropipecolic acid reductase", "d": ["Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038025", "l": "reelin receptor activity", "d": ["Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68610", "l": "Formation of ORC(2-5) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53302", "l": "H(+) + N-carbamoyl-D-methionine => D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10187", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O <=> 3-oxoadipate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709360", "l": "H2O2 reduces MetHb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17109", "l": "FMNH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794444", "l": "ALB binds Cipro (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16786", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33232", "l": "H2O2 + heme b => heme d cis-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40972", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70255", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322434", "l": "XIAP dissociates from ub-TLE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809309", "l": "MTMR6 binds MTMR9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13545", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] = (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.58", "l": "\"trimethyltridecatetraene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018766", "l": "RHOU binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27760", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794346", "l": "NRXNs bind NLGNs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32583", "l": "dihydrocarvone + H(+) + NADPH + O2 = 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13998", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) => 2-methylpropanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19210", "l": "codeine + NADP(+) => codeinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29609", "l": "H(+) + NADH + 2 nitric oxide => H2O + NAD(+) + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54395", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:1901474", "l": "azole transmembrane transporter activity", "d": ["Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37090", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009046", "l": "zinc D-Ala-D-Ala carboxypeptidase activity", "d": ["Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216043", "l": "Collagen type II binds integrin alpha10beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46990", "l": "6-hydroxy-N-methylmyosmine + H2O2 => (R)-6-hydroxynicotine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791323", "l": "TP53 stimulates BCL2L14 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48720", "l": "aurachin B + H2O + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.394", "l": "\"aurachin B dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58552", "l": "15alpha-stemmadenine intermediate II + H2O = (16R)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674531", "l": "AAMP binds EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670417", "l": "Dimerization of STATs downstream of KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49359", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47729", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68274", "l": "CoA + O-fatty acyl-L-seryl-[protein] => a fatty acyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676926", "l": "Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68125", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] => a triacylglycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34488", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28785", "l": "glycine + L-cysteine => H2O + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948775", "l": "MKRN1 polyubiquitinates PTEN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797974", "l": "LRRTMs bind NRXNs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38883", "l": "a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23148", "l": "ATP + propanoate = ADP + propanoyl phosphate", "d": [], "t": []}, {"i": "EC:2.7.2.15", "l": "\"propionate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66610", "l": "GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate) => (tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21978", "l": "[thioredoxin]-dithiol + adenosine 5'-phosphosulfate => [thioredoxin]-disulfide + AMP + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40122", "l": "H2O + tetradecanoyl-CoA <=> CoA + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759158", "l": "SQSTM1 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62905", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55227", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71377", "l": "2 Na(+)(in) + testosterone 17-sulfate(in) => 2 Na(+)(out) + testosterone 17-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160140", "l": "23S rRNA pseudouridine(1911/1915/1917) synthase activity", "d": ["Catalysis of the reaction: uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59724", "l": "D-maltoheptaono-1,5-lactone + H2O = D-maltoheptaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73729", "l": "Formation of SL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38936", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14993", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.85", "l": "\"fatty-acid synthase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40849", "l": "(2E)-eicosenoyl-CoA + FADH2 => eicosanoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62745", "l": "H2O + mevastatin => (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.9", "l": "\"spheroidene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418172", "l": "F2R binds ARRB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050376", "l": "UDP-glucosamine 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41695", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53301", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O => H(+) + N-carbamoyl-D-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67195", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75337", "l": "bromide(out) + chloride(in) => bromide(in) + chloride(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50393", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline => 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15128", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) <=> CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0008119", "l": "thiopurine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57872", "l": "(E)-2,4-dihydroxycinnamoyl-CoA = CoA + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39757", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25724", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53939", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395320", "l": "Latent TGF-beta-1 binds integrins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54006", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63344", "l": "ATP + L-amino acyl-L-threonyl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76589", "l": "(2S)-5,5-dimethylpiperidine-2-carboxylate + A + 2 CO2 + H2O + succinate => (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + 2-oxoglutarate + AH2 + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43345", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54783", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000252", "l": "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity", "d": ["Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27855", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate => 3-geranyl-4-hydroxybenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66255", "l": "ATP + CoA + IC-asc-C7 <=> AMP + diphosphate + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22156", "l": "GDP + H2O = GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696358", "l": "TREM,CD300 binds lipids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71317", "l": "chloride(in) + L-serine(in) + 2 Na(+)(in) => chloride(out) + L-serine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202241", "l": "Recruitment of SLP-76 to Gads (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38556", "l": "an all-trans-retinyl ester + H2O => a fatty acid + all-trans-retinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15303", "l": "aldehydo-D-apiose + H(+) + NADH => D-apiitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48288", "l": "a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20289", "l": "acetyl-CoA + H2O = acetate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.1", "l": "\"acetyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75639", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate = (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140804", "l": "NAD+- protein-lysine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:58220", "l": "L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31233", "l": "4-acetamidobutanoate + 2 H(+) + NADH => 4-acetamidobutanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0047429", "l": "nucleoside triphosphate diphosphatase activity", "d": ["Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48783", "l": "ATP + L-erythrulose <=> ADP + H(+) + L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65601", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) => 2 H(+) + jolkinol C + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055042", "l": "5-valerolactone hydrolase activity", "d": ["Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158849", "l": "Phenol can form a sulfate conjugate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70850", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) <=> L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61628", "l": "5-aminopentanal = 1-piperideine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002112", "l": "interleukin-33 receptor binding", "d": ["Binding to an interleukin-33 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416698", "l": "SEMA5A binds to PLXNB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58283", "l": "4 ATP <=> cyclic tetraadenylate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47394", "l": "an aliphatic alcohol + H(+) + hexadecanoate => H2O + hexadecanoate ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11966", "l": "5alpha-cholestane-3beta,5,6beta-triol => 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863727", "l": "STON2 is neddylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033941", "l": "mannan exo-1,2-1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662606", "l": "MT3 binds zinc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649671", "l": "NEIL1 recognizes and binds FapyA-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43387", "l": "ATP + L-arginyl-[protein] <=> ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170159", "l": "Translocation of Cdc25 to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52987", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40525", "l": "a quinol + fumarate => a quinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48726", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => aurachin B + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13769", "l": "glycerol + NAD(+) = dihydroxyacetone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.6", "l": "\"glycerol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69971", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75010", "l": "H(+)(out) + VO(2+)(out) <=> H(+)(in) + VO(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209823", "l": "Tyrosine is hydroxylated to dopa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23956", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42231", "l": "17beta-estradiol + A <=> AH2 + estrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9017491", "l": "RHOJ GEFs activate RHOJ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.109", "l": "\"endogalactosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27514", "l": "H2O + sphinganine 1-phosphate = phosphate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691131", "l": "CANDI binds CUL1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018454", "l": "acetoacetyl-CoA reductase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950398", "l": "CANX dissociates from IL27:EBI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193646", "l": "NGF binding to p75NTR inactivates RHOA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22113", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60828", "l": "a 5'-end triphospho-adenosine in mRNA + H2O = a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53177", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42430", "l": "(3R,5R)-clavulanate-9-aldehyde => clavaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53577", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15131", "l": "(1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158860", "l": "SULT1A1 dimer sulfonates NHABP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050116", "l": "N,N-dimethylformamidase activity", "d": ["Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64402", "l": "an L-amino acid tripeptide(in) + H(+)(in) => an L-amino acid tripeptide(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48064", "l": "a ganglioside GD1b (d18:1(4E)) + H2O = a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60359", "l": "H2O + N-octanoylanthranilate <=> anthranilate + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25038", "l": "ATP + L-seryl-tRNA(Sec) => ADP + O-phospho-L-seryl-tRNA(Sec)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45539", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39272", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA => (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37337", "l": "3-(carbamoylamino)-2-methylpropanoate + H(+) => 5,6-dihydrothymine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57102", "l": "S-methyl-1-thio-D-xylulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48308", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": [], "t": []}, {"i": "EC:4.1.2.44", "l": "\"2,3-epoxybenzoyl-CoA dihydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30702", "l": "2-oxoglutarate + beta-alanine <=> 3-oxopropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38781", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44311", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14784", "l": "ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71800", "l": "Ca(2+)(in) + H(+)(out) => Ca(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34199", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = bracteatin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047060", "l": "(R)-pantolactone dehydrogenase (flavin) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389354", "l": "Activation of Vav1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54271", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52084", "l": "13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60797", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 => 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68456", "l": "(S)-3-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17844", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786101", "l": "IL4 binds IL4R:JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39318", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA <=> (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71790", "l": "2-oxoadipate + O2 <=> (R)-2-hydroxyglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159773", "l": "Furin cleaves pro-protein S to protein S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50544", "l": "prostaglandin C2 = prostaglandin B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58128", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050185", "l": "phosphatidylinositol deacylase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24560", "l": "acetyl-CoA + L-serine = CoA + O-acetyl-L-serine", "d": [], "t": []}, {"i": "EC:2.3.1.30", "l": "\"serine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64502", "l": "3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018612", "l": "dibenzothiophene dioxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16578", "l": "ADP + ATP + H(+) => P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59488", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74078", "l": "H(+) + NADH + phylloquinone <=> NAD(+) + phylloquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050345", "l": "trans-epoxysuccinate hydrolase activity", "d": ["Catalysis of the reaction: trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874797", "l": "EGFR gene expression is stimulated by TFAP2C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17940", "l": "dihydroxyacetone phosphate <=> methylglyoxal + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45118", "l": "H(+) + ipsdienone + NADPH => (4R)-ipsdienol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30593", "l": "(4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218811", "l": "DOCK180:ELMO binds CRK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10936", "l": "6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate", "d": [], "t": []}, {"i": "EC:1.8.5.2", "l": "\"thiosulfate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18004", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182986", "l": "CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174097", "l": "Association of Emi1 with Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22012", "l": "precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.133", "l": "\"precorrin-4 C(11)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34515", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.36", "l": "\"undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50246", "l": "3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10963", "l": "(S)-lactate <=> (R)-lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9660557", "l": "RAS:GTP binds RAL GDS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9708275", "l": "PDE4A binds PDE4A inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13653", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.10", "l": "\"levansucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033530", "l": "TYSND1 cleaves HSD17B4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950533", "l": "Expression of Ras-related protein Ral-A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0045510", "l": "interleukin-24 binding", "d": ["Binding to interleukin-24."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33290", "l": "A + spermidine <=> 1-pyrroline + AH2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37634", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018765", "l": "2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11301", "l": "1D-5-O-methyl-myo-inositol + NAD(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004370", "l": "glycerol kinase activity", "d": ["Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47700", "l": "H(+) + ketocytochalasin + NADPH + O2 = H2O + iso-precytochalasin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696323", "l": "CNRs bind CNR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299480", "l": "Precursor proteins enter TIMM23 PAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33759", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH = a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25118", "l": "H2O + L-lysine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65255", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein <=> diphosphate + verruculide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168376", "l": "STIM1 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64692", "l": "isobutanol + NAD(+) = 2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37076", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48497", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose => 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043287", "l": "poly(3-hydroxyalkanoate) binding", "d": ["Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26071", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O <=> CoA + H(+) + phosphinomethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112396", "l": "Separation of elongating transcript from template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050158", "l": "dihydroorotate dehydrogenase (NADPH) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + NADP+ = H+ + NADPH + orotate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21032", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.17", "l": "\"glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51870", "l": "demethylsuberosin + diphosphate => dimethylallyl diphosphate + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205238", "l": "SHP2 interacts with p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40440", "l": "6-sulfo-beta-D-quinovose => 6-deoxy-6-sulfo-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76641", "l": "cytosine(in) => cytosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036163", "l": "3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity", "d": ["Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61703", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] <=> AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.70", "l": "\"oligopeptidase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60126", "l": "diphosphate + sodorifen => pre-sodorifen diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005291", "l": "high-affinity L-histidine transmembrane transporter activity", "d": ["Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36434", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58693", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV => FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23190", "l": "3-hydroxypropanal + H(+) + NADH => NAD(+) + propane-1,3-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70128", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76051", "l": "(S)-scoulerine + S-adenosyl-L-methionine = (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73187", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102652", "l": "gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 = gibberellin A51 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26135", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52123", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56735", "l": "4,4-dihydroxy-all-trans-beta-carotene <=> echinenone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183067", "l": "Localization of CBL:GRB2 to the membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46098", "l": "4 CO2 + 4 CoA + dihydropinosylvin => 3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692880", "l": "HRH3 binds Hist (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004767", "l": "sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805640", "l": "AKT phosphorylates KAT6A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762246", "l": "ANGPTL4 binds CDH11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41700", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047814", "l": "D-arabinokinase activity", "d": ["Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41498", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362522", "l": "ALDHs oxidise atRAL to atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16564", "l": "H2O + squalene <=> hopan-22-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018585", "l": "fluorene oxygenase activity", "d": ["Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51879", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate <=> desmethylxanthohumol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69915", "l": "guanosine(out) + 2 Na(+)(out) = guanosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015506", "l": "nucleoside:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48270", "l": "canthaxanthin + H2O => 4',4'-dihydroxyechinenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68535", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070095", "l": "fructose-6-phosphate binding", "d": ["Binding to fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.97", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49435", "l": "cholate + lithocholoyl-CoA <=> choloyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870466", "l": "RGGT:CHM binds RABs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21513", "l": "3,6-anhydro-L-galactonate => 2-dehydro-3-deoxy-L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66715", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047061", "l": "glucose-fructose oxidoreductase activity", "d": ["Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047101", "l": "branched-chain alpha-keto acid dehydrogenase activity", "d": ["Catalysis of the reaction: [a branched-chain alpha-keto acid] + CoA + NAD+ = [a branched-chain acyl-CoA] + CO2 + NADH. This enzyme system catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44534", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18970", "l": "a long-chain fatty acid + H(+) + hnu => a long-chain alkane + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090079", "l": "GLB1 hydrolyses linker chain(2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698926", "l": "HCMV Genome Replication Completion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944250", "l": "Association of procollagen type XXV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47560", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49990", "l": "H2O + methyl acetate + NADP(+) => acetone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202222", "l": "Phosphorylation of PKC theta (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53232", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51236", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) = GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398184", "l": "LARG activation by G alpha 12/13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.74", "l": "\"deoxycytidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35439", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine = archaetidylserine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46620", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23445", "l": "(S)-lactate + NAD(+) => H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20435", "l": "D-xylulose + H(+) + NADH => NAD(+) + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549368", "l": "Defective ALG2 does not transfer a second Man to N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296326", "l": "HCAR1 binds LACT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418904", "l": "A1 and A3 receptors bind adenosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62842", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10879", "l": "4-hydroxybenzoate + H(+) <=> CO2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956659", "l": "ABL1 phosphorylates YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14494", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] => ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031963", "l": "nuclear cortisol receptor activity", "d": ["Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76478", "l": "hexadecan-1-ol + O2 <=> H2O2 + hexadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44431", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50997", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251557", "l": "Expression of AMER1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42976", "l": "L-tryptophan = 2-aminoprop-2-enoate + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50478", "l": "CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => anthraniloyl-CoA + L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20608", "l": "cytosine + H(+) + H2O <=> NH4(+) + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75250", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73078", "l": "luteolin + S-adenosyl-L-methionine <=> H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37059", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": [], "t": []}, {"i": "EC:2.3.1.234", "l": "\"N(6)-L-threonylcarbamoyladenine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61861", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 => epoxybetaenone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51341", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62838", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30860", "l": "dITP + H2O => dIDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66783", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O <=> N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693012", "l": "TNFSF15 binds TNFRSF25 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102272", "l": "homophytochelatin synthase activity (polymer-forming)", "d": ["Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55957", "l": "(9Z)-octadecenoate + AH2 + O2 => (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5671737", "l": "p-T774-PKN1 binds CDC25C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990206", "l": "jasmonyl-Ile conjugate hydrolase activity", "d": ["Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18217", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-aminoaldehyde + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.29", "l": "\"diamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432148", "l": "Fgr may phosphorylate p38 MAPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030882", "l": "lipid antigen binding", "d": ["Binding to a lipid antigen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18765", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}, {"i": "EC:2.7.8.27", "l": "\"sphingomyelin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53054", "l": "4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50063", "l": "ATP + glycochenodeoxycholate(in) + H2O <=> ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64875", "l": "D-ribulose 1-phosphate <=> dihydroxyacetone phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016941", "l": "natriuretic peptide receptor activity", "d": ["Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36966", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13041", "l": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate", "d": [], "t": []}, {"i": "EC:5.3.3.12", "l": "\"L-dopachrome isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19648", "l": "a D-threo-aldose + NAD(+) <=> a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76126", "l": "a dicarboxylate(in) + prostaglandin E2(out) <=> a dicarboxylate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69536", "l": "alpha-D-tagatopyranose 1-phosphate + ATP = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.234", "l": "\"D-tagatose-1-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002170", "l": "high-affinity IgA receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047447", "l": "erythro-3-hydroxyaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20057", "l": "2 H(+) + H2O + N-carbamoylsarcosine = CO2 + NH4(+) + sarcosine", "d": [], "t": []}, {"i": "EC:3.5.1.59", "l": "\"N-carbamoylsarcosine amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183126", "l": "Factor B binds to surface-associated C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799409", "l": "HIPK2 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17636", "l": "a beta-D-glucuronoside + H2O <=> an alcohol + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70513", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.144", "l": "\"3-deoxyoctulosonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49895", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 <=> (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59349", "l": "D-maltobiono-1,5-lactone + H2O => D-maltobionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64098", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP] => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53463", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31501", "l": "a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42959", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33293", "l": "(E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32621", "l": "H(+) + NADPH + sepiapterin => L-threo-7,8-dihydrobiopterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102275", "l": "cysteine-S-conjugate N-malonyl transferase activity", "d": ["Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate = coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50310", "l": "11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377644", "l": "Release of CSK from SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70802", "l": "L-lysine(in) + L-ornithine(out) <=> L-lysine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140337", "l": "diacylglyceride transfer activity", "d": ["Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26022", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O <=> beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17606", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17199", "l": "2 4-hydroxyphenylacetate + 2 CO2 => 2 3-(4-hydroxyphenyl)pyruvate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19154", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose => 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45834", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3R)-3-hydroxydecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530445", "l": "CD59 inhibits MAC formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586553", "l": "JAK2 Phosphorylates LEPR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67652", "l": "dADP + H2O = 2'-deoxyadenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106327", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68746", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine => 2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817458", "l": "TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607023", "l": "factor IXa associates with cell membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54232", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77342", "l": "(2S)-2-aminobutanoate + glyoxylate <=> 2-oxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.9", "l": "\"adenosylhomocysteine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23769", "l": "a fatty acyl-CoA + sphing-4-enine => an N-acylsphing-4-enine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42717", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701147", "l": "TRPV1 binds TRPV1 blockers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44185", "l": "D-sedoheptulose 7-phosphate => 2-epi-5-epi-valiolone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67136", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297275", "l": "CD9:Izumo Binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59603", "l": "5-methoxytryptamine + H2O + O2 <=> 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333615", "l": "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29006", "l": "H(+)(out) + L-homoserine(in) <=> H(+)(in) + L-homoserine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030346", "l": "protein phosphatase 2B binding", "d": ["Binding to a protein phosphatase 2B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17741", "l": "NAD(+) + shikimate = 3-dehydroshikimate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32412", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59608", "l": "beta-alanyl-L-lysine + H2O = beta-alanine + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54261", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023346", "l": "MECP2 binds NOTCH1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390846", "l": "D2D3,4 bind to DA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727607", "l": "MME:Zn2+ binds sacubitrilat (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19898", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005354", "l": "galactose transmembrane transporter activity", "d": ["Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose."], "t": []}, {"i": "RHEA:34915", "l": "D-galactose(in) = D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001855", "l": "complement component C4b binding", "d": ["Binding to a C4b product of the classical complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52623", "l": "3-methylbutanoyl-CoA <=> 2,2-dimethylpropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140862", "l": "histone H2AK119 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20198", "l": "[heparosan-N-sulfate](n) => [heparan-N-sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71853", "l": "glycocholate(in) => glycocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56855", "l": "reumycin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332235", "l": "CBL binds TGFBR2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016216", "l": "isopenicillin-N synthase activity", "d": ["Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265443", "l": "NPC1L1-mediated cholesterol uptake (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.3", "l": "\"thiazoline synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031624", "l": "ARC gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791071", "l": "Expression of PLA2G4B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14495", "l": "ADP-D-ribose + L-arginyl-[dinitrogen reductase] => H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16863", "l": "(7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate => (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70385", "l": "CoA + H(+) + N-hexadecanoyl-3-oxosphinganine => 3-oxosphinganine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32340", "l": "(+)-thujan-3-ol + NADP(+) => (+)-thujan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27875", "l": "isochorismate => pyruvate + salicylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60349", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45862", "l": "4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44993", "l": "(R)-carnitine + 2-methylbutanoyl-CoA => CoA + O-2-methylbutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40841", "l": "(2E)-nonenoyl-CoA + FADH2 => FAD + H(+) + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30289", "l": "9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol => 15-cis-phytoene + 2 a plastoquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74740", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine => 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433415", "l": "Activation of RAC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10215", "l": "2-oxoglutarate + 5-aminopentanoate <=> 5-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73885", "l": "guanidine(in) => guanidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58156", "l": "ATP + H2O + 4 Na(+)(in) = ADP + H(+) + 4 Na(+)(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.1", "l": "\"Na(+)-transporting two-sector ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0016675", "l": "oxidoreductase activity, acting on a heme group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.9.-.-", "l": "\"Acting on a heme group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15962", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose => H(+) + taxiphyllin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11178", "l": "beta-D-glucose 1-phosphate + D-glucose => kojibiose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.14", "l": "\"L-iditol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623588", "l": "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913374", "l": "Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015151", "l": "alpha-glucoside transmembrane transporter activity", "d": ["Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57998", "l": "(20S)-ginsenoside Rh2 + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56215", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70105", "l": "penilactone B => H(+) + o-quinone methide + penilactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39136", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25341", "l": "H(+) + urea <=> isocyanate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192051", "l": "CYP7A1 7-hydroxylates CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68771", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30628", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) => (2S)-2-acetolactate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730887", "l": "Autophosphorylation and activation of MEKK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60072", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035484", "l": "adenine/adenine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/A mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047082", "l": "3,9-dihydroxypterocarpan 6a-monooxygenase activity", "d": ["Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H+ + NADPH + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.57", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36380", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH => 4alpha-methylzymosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68129", "l": "a fatty acyl-CoA + phytol => a fatty acid phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73014", "l": "L-leucine(in) <=> L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013109", "l": "RHOC GEFs activate RHOC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373140", "l": "isocitrate <=> citrate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433415", "l": "Activation of RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042768", "l": "ecdysteroid 2-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15041", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O = inulobiose", "d": [], "t": []}, {"i": "EC:4.2.1.179", "l": "\"difructose-anhydride-I synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31881", "l": "beta-seco-amyrin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69836", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42814", "l": "cholesteryl octadecanoate + CoA => cholesterol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25904", "l": "futalosine + H2O = dehypoxanthine futalosine + hypoxanthine", "d": [], "t": []}, {"i": "EC:3.2.2.26", "l": "\"futalosine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58920", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (+)-medicarpin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160931", "l": "Disassembly of tight junctions (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617182", "l": "PRKACA phosphorylates PLN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48135", "l": "(2E,6E)-farnesyl phosphate + H2O <=> (2E,6E)-farnesol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446372", "l": "Association of  PARVA with TESK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202713", "l": "CD84 homodimerises (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71517", "l": "hypoxanthine(in) => hypoxanthine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15049", "l": "GDP-alpha-D-glucose + H2O = D-glucose + GDP + H(+)", "d": [], "t": []}, {"i": "EC:3.2.1.42", "l": "\"GDP-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2167942", "l": "Collagen type XIII ectodomain shedding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51410", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14036", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64267", "l": "atrochrysone carboxylate + H(+) <=> atrochrysone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48899", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29782", "l": "ATP + H2O + L-methionine(out) <=> ADP + H(+) + L-methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49873", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36784", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106586", "l": "WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51578", "l": "H(+) + phlorizin + UDP => phloretin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46355", "l": "(2E)-decenoyl-CoA + H2O <=> 3-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59398", "l": "D-leucine => L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984671", "l": "Chromokinesins form dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167047", "l": "pro-beta-NGF dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47217", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23383", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58548", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39100", "l": "3-oxodecanedioyl-CoA + CoA => acetyl-CoA + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76445", "l": "choline(in) + n Na(+)(in) => choline(out) + n Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28997", "l": "H(+)(in) + L-threonine(out) => H(+)(out) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753634", "l": "GGT dimers hydrolyse APAP-SG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229132", "l": "AP4 binds APP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65556", "l": "a globoside GalGb4Cer + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47094", "l": "dipicolinate + H(+) + NADPH => (S)-2,3-dihydrodipicolinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071972", "l": "peptidoglycan L,D-transpeptidase activity", "d": ["Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214398", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731931", "l": "EDNRA binds selective ERAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65480", "l": "2-methylbutanoyl-CoA + hexan-1-ol = CoA + hexyl 2-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54899", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA <=> (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388814", "l": "Grb2 binds CD28 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202472", "l": "Translocation of TRAF6 to CBM complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0008990", "l": "rRNA (guanine-N2-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26289", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.11", "l": "\"cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59959", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate <=> a nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050281", "l": "serine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592297", "l": "Full activation of MMP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047175", "l": "galactosylacylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047151", "l": "tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13135", "l": "a dolichyl phosphate + CDP + H(+) => CTP + di-trans,poly-cis-dolichol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40851", "l": "FAD + H(+) + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37213", "l": "guanosine 2'-monophosphate + H(+) => 2',3'-cyclophospho-GMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64292", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH = (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43484", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11128", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71636", "l": "phosphate(in) + 2 thiosulfate(out) => phosphate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71069", "l": "L-arginine(out) + L-phenylalanine(in) => L-arginine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604712", "l": "Initial activation of proMMP7 by trypsin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482770", "l": "Release of platelet secretory granule components (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58098", "l": "glycerol + H(+) + tetracosanoate => 1-tetracosanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69769", "l": "(E)-non-2-enoate + 2 H(+) + NADH => (E)-non-2-enal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14322", "l": "morphine + NADP(+) => H(+) + morphinone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43882", "l": "(25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate => (25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13449", "l": "2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59170", "l": "AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35622", "l": "L-idarate <=> D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67964", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine = 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16769", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10412", "l": "ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10692", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": [], "t": []}, {"i": "EC:1.3.3.11", "l": "\"pyrroloquinoline-quinone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61775", "l": "rebaudioside E + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865774", "l": "TTLLs polyglutamylate tubulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021325", "l": "NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021847", "l": "CREB1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374337", "l": "Apelin receptor binds to apelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357479", "l": "p-AXL binds PI3K (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698333", "l": "Spike trimer moves into the ERGIC membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21581", "l": "(2S)-2-acetolactate + H(+) => (R)-acetoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29438", "l": "enterobactin(in) + H(+)(out) <=> enterobactin(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18598", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] => NADH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350147", "l": "VD3 translocates from extracellular region to ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50843", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51767", "l": "dimethylallyl diphosphate + phlorisovalerophenone <=> 4-prenylphlorisovalerophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25962", "l": "benzil + H(+) + NADPH => benzoin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72118", "l": "glycine betaine(out) + Na(+)(out) <=> glycine betaine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55624", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O = 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13780", "l": "ATP + D-ribose 5-phosphate + NH4(+) <=> 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202714", "l": "CD58 binds CD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69712", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-glucose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76393", "l": "glycylglycylglycine(in) + n H(+)(in) => glycylglycylglycine(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050408", "l": "[pyruvate kinase]-phosphatase activity", "d": ["Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201717", "l": "CSNK2-mediated phosphorylation of DVL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937807", "l": "SRC phosphorylates RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55991", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445699", "l": "ATP Hydrolysis By Myosin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71421", "l": "3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out) => 3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018747", "l": "RHOQ GEFs activate RHOQ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55469", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65897", "l": "glyoxylate + L-kynurenine => glycine + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34136", "l": "cannabigerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38993", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047778", "l": "[citrate-(pro-3S)-lyase] thiolesterase activity", "d": ["Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663122", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NAMPT gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48658", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12952", "l": "D-fuconate <=> 2-dehydro-3-deoxy-D-fuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45564", "l": "2-epi-5-epi-valiolone = 5-epi-valiolone", "d": [], "t": []}, {"i": "EC:5.1.3.33", "l": "\"2-epi-5-epi-valiolone epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48195", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71338", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41365", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24316", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-copalyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.12", "l": "\"copalyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16484", "l": "3 S-adenosyl-L-methionine <=> 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444100", "l": "PROT mediates L-proline uptake (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31265", "l": "but-3-yn-1-ol + pyrroloquinoline quinone => but-3-ynal + H(+) + pyrroloquinoline quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62600", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75260", "l": "isoorientin + O2 => 3'-dehydroisoorientin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0004357", "l": "glutamate-cysteine ligase activity", "d": ["Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247513", "l": "STAB1:ligand is endocytosed (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39246", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35956", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B => 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17840", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O <=> 2-carboxy-D-arabinitol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090682", "l": "GPCR bitter taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of bitter taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59797", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29101", "l": "a menaquinol + 4 H(+)(out) + NAD(+) => a menaquinone + 5 H(+)(in) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28680", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009488", "l": "IL34 binds CSF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769394", "l": "AKT phosphorylates CBY1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008147", "l": "structural constituent of bone", "d": ["The action of a molecule that contributes to the structural integrity of bone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725206", "l": "IgE binds FCERI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74099", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22606", "l": "D-fructose => D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19778", "l": "A + L-pipecolate => AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58119", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10951", "l": "ATP + D-glucosamine <=> ADP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20998", "l": "(3E)-2-oxohex-3-enedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60446", "l": "an S-substituted L-cysteine + glycine => an S-substituted L-cysteinylglycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19538", "l": "D-mannitol 1-phosphate + H2O => D-mannitol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168870", "l": "Neuraminidase enzymatic release from sialic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174070", "l": "Association of Cdh1 with the APC/C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76923", "l": "2-methylcyclopentanamine + H2O + NADP(+) = 2-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13810", "l": "aspulvinone E + 2 dimethylallyl diphosphate => aspulvinone H + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64643", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose <=> lactose + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11197", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide => alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22242", "l": "N-(carboxyaminomethyl)urea + NH4(+) => H2O + methylenediurea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65492", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": [], "t": []}, {"i": "EC:1.3.98.7", "l": "\"[mycofactocin precursor peptide]-tyrosine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48817", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211191", "l": "Association of DFF with alpha:beta importin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31596", "l": "(Z)-2-methylureidoacrylate + H2O => (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18763", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34758", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine <=> D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693478", "l": "HTR1A binds HTR1A agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22594", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140871", "l": "repressor of RNA polymerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52754", "l": "beta-D-glucose + D-glucose => H2O + isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73113", "l": "ladanein + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34795", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.55", "l": "\"phosphoribosyl 1,2-cyclic phosphate phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61366", "l": "ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate => ATP + dehydroepiandrosterone 3-sulfate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340214", "l": "CYGB binds O2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54839", "l": "H(+) + heptan-2-one + NADPH + O2 <=> H2O + NADP(+) + pentyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216043", "l": "Collagen type II binds integrin alpha10beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72901", "l": "proatranorin I + S-adenosyl-L-homocysteine => 4-O-demethylbarbatate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41270", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine <=> (15Z)-tetracosenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18144", "l": "NAD(+) + trans-cyclohexane-1,2-diol <=> 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12157", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49676", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 = H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981713", "l": "C4b binds to cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63113", "l": "A + ascofuranol => AH2 + ascofuranone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39224", "l": "(3R)-hydroxyoctacosanoyl-CoA => (2E)-octacosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702570", "l": "KW2449-resistant FLT3 mutants don't bind KW2449 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27683", "l": "ATP + dTDP => ADP + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14375", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60318", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26401", "l": "all-trans-10'-apo-beta-carotenal + O2 = (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": [], "t": []}, {"i": "EC:1.13.11.70", "l": "\"all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49517", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10559", "l": "D-glyceraldehyde 3-phosphate + L-arginine <=> H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835411", "l": "FA core complex:HSP70s binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66071", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34774", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) <=> a 3-oxosteroid + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017983", "l": "MECP2 binds CRH gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34472", "l": "NAD(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28792", "l": "5,6-dihydrothymine + NAD(+) => H(+) + NADH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388560", "l": "EDNRA,EDNRB bind EDNs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22018", "l": "arsenite + glutathionyl-S-S-[glutaredoxin] + H2O => [glutaredoxin]-dithiol + arsenate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649733", "l": "mature p21 RAS binds GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15064", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) <=> 2 a Fe(III)-siderophore + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70800", "l": "L-lysine(in) + L-ornithine(out) => L-lysine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.6", "l": "\"acetone carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043125", "l": "ErbB-3 class receptor binding", "d": ["Binding to the protein-tyrosine kinase receptor ErbB-3/HER3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806413", "l": "TP53 binds the MLH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110011", "l": "Binding of Grb10 to the insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19785", "l": "2-oxoglutarate + dihydroclavaminate + O2 = clavaminate + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49124", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = H2O + NADP(+) + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60803", "l": "2-oxoglutarate + gibberellin A53 + O2 <=> CO2 + gibberellin A44 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65305", "l": "2-oxoglutarate + O2 + verruculide A => chrodrimanin T + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72251", "l": "(R)-adrenaline + S-adenosyl-L-methionine = (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.49", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132276", "l": "Complement factor I inactivates C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672011", "l": "p-AMPK:AMP binds the ULK complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63794", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22165", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47769", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44366", "l": "2-epi-5-epi-valiolone 7-phosphate + ADP + H(+) => 2-epi-5-epi-valiolone + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54758", "l": "AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide => deamido-NAD(+) + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004080", "l": "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877361", "l": "Pyrin binds ASC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733216", "l": "COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23114", "l": "3-methylphenol + CO2 => 6-methylsalicylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.199", "l": "\"beta-mannosylphosphodecaprenol--mannooligosaccharide 6-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12298", "l": "dopamine + secologanin => deacetylipecoside + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15439", "l": "a long-chain fatty acyl-CoA + H(+) + NADPH => a long-chain fatty aldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74186", "l": "S-adenosyl-L-methionine + taxifolin <=> H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19956", "l": "a 2-oxocarboxylate + L-alanine <=> an L-alpha-amino acid + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29680", "l": "formate(in) => formate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23218", "l": "3-hydroxybenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36793", "l": "hydroxyurea + L-ornithine => H2O + N(omega)-hydroxy-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36296", "l": "alpha-maltose 6'-phosphate + H2O => D-maltose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392834", "l": "Activation of EPACs by cAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25011", "l": "H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624353", "l": "NR1H2,3 binds the PLTP gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69658", "l": "H2O + quercetin 3-O-beta-D-glucoside <=> beta-D-glucose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.-.-", "l": "\"Other lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21925", "l": "3-dehydro-L-gulonate + NAD(+) => 2,3-dioxo-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.-", "l": "\"Dipeptide hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750226", "l": "NLRC5 binds IKBKB and CHUK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40402", "l": "1,2-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17209", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.2.18", "l": "\"enamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018783", "l": "deisopropyldeethylatrazine hydrolase activity", "d": ["Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23041", "l": "2-oxobutanoate + acetyl-CoA + H2O => (R)-2-ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35092", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine => 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35457", "l": "(25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+) => 5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70667", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0034071", "l": "aminoglycoside phosphotransferase activity", "d": ["Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021520", "l": "NOTCH3 binds WWP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50113", "l": "octadecanoyl-CoA + taurine => CoA + H(+) + N-octadecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70080", "l": "2-oxoglutarate + clavatol + O2 => CO2 + hydroxyclavatol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43133", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.73", "l": "\"u-plasminogen activator\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200396", "l": "Creatine transport across the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52873", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0032067", "l": "type IV site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32159", "l": "AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA", "d": [], "t": []}, {"i": "EC:1.17.99.6", "l": "\"epoxyqueuosine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62314", "l": "H(+) + salicylate 2-O-beta-D-glucoside + UDP => salicylate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16605", "l": "dodecanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.2", "l": "\"decylcitrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71569", "l": "5-O-(L-seryl)-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62629", "l": "a hydroperoxide + H(+) + NADH => an alcohol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805426", "l": "CARD8 binds CASP9(1-416) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878056", "l": "RUNX1:CBFB binds EP300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63881", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate => cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49514", "l": "phosphinomethylisomalate => 2-(phosphinatomethylidene)butanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70797", "l": "H(+)(out) + L-lysine(in) => H(+)(in) + L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61209", "l": "8-nitro-cGMP + L-cysteinyl-[protein] => H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18902", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine => benzyl alcohol + CO2 + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11777", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20205", "l": "methylazoxymethanol + UDP-alpha-D-glucose = cycasin + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.171", "l": "\"methyl-ONN-azoxymethanol beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204779", "l": "Interaction of Tie2 with Ang1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24963", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 <=> [excited state blue fluorescent protein] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47249", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50153", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66416", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O = ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60143", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102806", "l": "4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine = shisonin + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75629", "l": "ectocarpin D => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74739", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627078", "l": "XIAP binds CASP9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018826", "l": "methionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52145", "l": "3-phosphonopyruvate + acetyl-CoA + H2O => (R)-2-(phosphonomethyl)malate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729307", "l": "Nucleoprotein is SUMOylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69358", "l": "3-bromo-L-tyrosyl-[protein] + H2O => H(+) + hypobromite + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11741", "l": "2 glutathione + NADP(+) => glutathione disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24570", "l": "an alcohol + D-galactose 6-phosphate => a 6-phospho-beta-D-galactoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8944457", "l": "MAF1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59360", "l": "carnosine + H2O = beta-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59094", "l": "[(1->3)-alpha-D-glucosyl](n+1) + D-fructose => [(1->3)-alpha-D-glucosyl](n) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0000179", "l": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "d": ["Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247837", "l": "WNT ligands traffic to the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.120", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65972", "l": "a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.14", "l": "\"ABC-type antigen peptide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912378", "l": "Sialylation of Pre-NOTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796066", "l": "AcK-NFE2L2 binds the CCL2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009309", "l": "RUNX2 binds STUB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14235", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54740", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53175", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647994", "l": "RAS proteins are depalmitoylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961619", "l": "CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54744", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662606", "l": "MT3 binds zinc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2282889", "l": "Defective ARSB does not hydrolyse C4S/C6S chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545203", "l": "Deacetylation of cleaved cohesin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75292", "l": "glyoxylate(in) + oxalate(out) => glyoxylate(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951644", "l": "Release of mature NEDD8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47792", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33371", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.201", "l": "\"protein-N(pi)-phosphohistidine--trehalose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705461", "l": "p-Y-STAT1,3,5 dimer binds SOCS1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030946", "l": "protein tyrosine phosphatase activity, metal-dependent", "d": ["Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853793", "l": "p-5Y-RET complexes bind GRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68262", "l": "D-serine(out) + Na(+)(out) => D-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42827", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54400", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201634", "l": "Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430135", "l": "p-SLP-76 binds ADAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45513", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64475", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine <=> (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.390", "l": "\"4,3-alpha-glucanotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69162", "l": "H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+) => agmatine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22065", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol => ergosterol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.180", "l": "\"brassinolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16467", "l": "2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c553]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23883", "l": "L-histidyl-[protein] + phosphoenolpyruvate <=> N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030624", "l": "U6atac snRNA binding", "d": ["Binding to a U6atac small nuclear RNA (U6atac snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030776", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938773", "l": "RNF144A polyubiquitinates PRKDC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029680", "l": "Caspase-7 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26177", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34471", "l": "NAD(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.95", "l": "\"acryloyl-CoA reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38061", "l": "1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77081", "l": "Formation of the CE:GMP intermediate complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63859", "l": "O2 + tetradecanoate <=> (2R)-2-hydroperoxytetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17280", "l": "6-phospho-D-gluconate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46811", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine <=> [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49621", "l": "D-erythritol 1-phosphate + NADP(+) => D-erythrulose 1-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73415", "l": "(-)-cyclopenine = H(+) + methyl isocyanate + viridicatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.5.2", "l": "\"L-cysteine S-thiosulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75285", "l": "10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39767", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51941", "l": "(1E,2S)-2-methylbutanal oxime => (1Z,2S)-2-methylbutanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65913", "l": "3-hydroxy-L-kynurenine + pyruvate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18468", "l": "L-dopa + O2 <=> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252001", "l": "ATP1B4 binds SNW1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18288", "l": "an N-acyl-D-aspartate + H2O <=> a carboxylate + D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68594", "l": "(6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34481", "l": "15-cis-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66656", "l": "Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676264", "l": "Formation of the SET1B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49248", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] = galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.200", "l": "\"protein-N(pi)-phosphohistidine--galactitol phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018768", "l": "RHOU auto-activates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675206", "l": "PEA15 binds MAPK monomers and dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191830", "l": "snRNP nuclear import and release (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55698", "l": "an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate => a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27326", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691421", "l": "BTK binds BTK inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59962", "l": "N(alpha)-acetyl-L-methionine => N(alpha)-acetyl-D-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28019", "l": "enterobactin + 3 H2O => 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69513", "l": "H2O + N-acetyl-D-galactosamine + O2 => H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76711", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23799", "l": "17-O-acetylnorajmaline + H2O <=> acetate + H(+) + norajmaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052908", "l": "16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62089", "l": "D-glucosamine 6-phosphate + NADP(+) => 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32131", "l": "(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46426", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.53", "l": "\"calpain-2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74135", "l": "petunidin + UDP-alpha-D-galactose = petunidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17023", "l": "L-alanine + phosphonoacetaldehyde => (2-aminoethyl)phosphonate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38352", "l": "(R)-3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52403", "l": "4-O-phospho-D-threonate + NAD(+) <=> 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45303", "l": "an N-(acyl)-sphingosylphosphocholine + H2O <=> an N-acyl-sphingoid base + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981892", "l": "Active G alpha (z) binds RGS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41287", "l": "H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696564", "l": "USP25 deubiquitinates DDX58 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51083", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71303", "l": "RPE dimers isomerise RU5P to XY5P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014467", "l": "RHOG binds effectors at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809521", "l": "BPIF binds bacteria (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65803", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O <=> a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112395", "l": "Abortive termination of elongation after arrest (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42112", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58467", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24816", "l": "2-oxoglutarate + L-valine <=> 3-methyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23208", "l": "acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate", "d": [], "t": []}, {"i": "EC:2.8.3.12", "l": "\"glutaconate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72062", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) <=> glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602458", "l": "Activation of proMMP10 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46373", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27339", "l": "15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68877", "l": "ATP + H(+) + NADPH + piperonylate => AMP + diphosphate + NADP(+) + piperonal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67919", "l": "adenosine 5'-phosphoramidate + H2O <=> AMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332359", "l": "Active calmodulin binds CAMK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726621", "l": "PGR binds PGR antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29090", "l": "(S)-malate + menaquinone-8 <=> menaquinol-8 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59657", "l": "D-cellotriose + O2 => D-cellotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27378", "l": "(R)-glycerate + ATP => (2R)-2-phosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49509", "l": "phosphinomethylmalate => 2-(phosphinatomethylidene)butanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706330", "l": "Active FLT3 binds to SOCS6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64564", "l": "8-epi-ilicicolin H = ilicicolin H", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420233", "l": "VIP receptors bind VIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222512", "l": "Nitric oxide oxidizes to nitrosyl ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011971", "l": "Estrogen-responsive MYB gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67373", "l": "H2O + L-seryl-L-threonine => L-serine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69547", "l": "ATP + streptidine <=> 6-O-adenylylstreptidine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76097", "l": "(11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0141057", "l": "histone H3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl = histone H3 L-citrullyl + NH4+, resulting in histone H3 citrullination."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16014", "l": "ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55306", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73393", "l": "H(+)(out) + phosphate(out) + sulfate(in) => H(+)(in) + phosphate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73385", "l": "thiamine diphosphate(out) + thiamine phosphate(in) => thiamine diphosphate(in) + thiamine phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42816", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609310", "l": "β-blockers bind ADRB1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199299", "l": "AKT phosphorylates FOXO transcription factors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47500", "l": "cholate + NADP(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052735", "l": "tRNA (cytidine-3-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = an N3-methylcytidine in tRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}, {"i": "RHEA:60908", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39366", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60454", "l": "acetaldehyde + H(+) + sulfite => 2-hydroxyethane-1-sulfonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42805", "l": "5,6,7,8-tetrahydromethanopterin + A => 7,8-dihydromethanopterin + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33215", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632677", "l": "PTCH is internalized (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015046", "l": "rubredoxin-NADP+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717461", "l": "PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938150", "l": "RUNX1:CBFB binds the PRKCQ gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811454", "l": "MAPKs phosphorylate PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030772", "l": "tryptophan 2-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392749", "l": "Transport of L1 into endosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191830", "l": "snRNP nuclear import and release (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50663", "l": "3-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27968", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23692", "l": "(R)-malate = H2O + maleate", "d": [], "t": []}, {"i": "EC:4.2.1.31", "l": "\"maleate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28201", "l": "(S)-1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50037", "l": "choloyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686587", "l": "ABL1 phosphorylates RAD52 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871494", "l": "SORL1 binds APP(18-770) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047995", "l": "hydroxyphenylpyruvate reductase activity", "d": ["Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57074", "l": "CO2 + L-erythrulose 1-phosphate => 3-oxoisoapionate 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791016", "l": "SFTPB binds itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52627", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71546", "l": "5-hydroxymethyl-dUMP in DNA + ATP <=> 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59649", "l": "D-xylotriono-1,5-lactone + H2O => D-xylotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23329", "l": "a 9-cis-epoxycarotenoid + O2 => 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45397", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46504", "l": "dodecanoyl-AMP + holo-[ACP] = AMP + dodecanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033295", "l": "hydroxyectoine binding", "d": ["Binding to hydroxyectoine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32466", "l": "glycine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59195", "l": "ATP + eicosanoate + H(+) <=> diphosphate + icosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130349", "l": "Generation of CLIP from lip10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624948", "l": "KIF17 enters the cilium (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38995", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70421", "l": "3,4-dihydroxyphenylacetate + CoA + H(+) => 3,4-dihydroxyphenylacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64532", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17225", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.1", "l": "\"6-hydroxynicotinate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016980", "l": "creatinase activity", "d": ["Catalysis of the reaction: creatine + H2O = sarcosine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332236", "l": "CBL neddylates TGFBR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39154", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17095", "l": "1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810843", "l": "Envoplakin binds periplakin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73966", "l": "(2E,6E)-farnesyl diphosphate <=> aristolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32800", "l": "urea(in) => urea(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46094", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50248", "l": "ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.96", "l": "\"ADP-D-ribose pyrophosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334794", "l": "FABPs bind LCFAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58914", "l": "ADP + H(+) + iron(III) dicitrate(in) + phosphate => ATP + H2O + iron(III) dicitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25039", "l": "ADP + O-phospho-L-seryl-tRNA(Sec) => ATP + L-seryl-tRNA(Sec)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55123", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023538", "l": "MECP2 binds PTPN1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23119", "l": "4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163551", "l": "triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044824", "l": "retroviral 3' processing activity", "d": ["The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58875", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37461", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31523", "l": "2-oxoglutarate + 2 H(+) + O2 = 3 CO2 + ethene + H2O", "d": [], "t": []}, {"i": "EC:1.13.12.19", "l": "\"2-oxoglutarate dioxygenase (ethylene-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903135", "l": "cupric ion binding", "d": ["Binding to a cupric ion, copper(2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22522", "l": "all-trans-retinoate + H(+) + H2O2 => all-trans-retinal + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11506", "l": "H(+) + S-adenosyl-L-homocysteine + sterigmatocystin => 6-demethylsterigmatocystin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40528", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) => 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004719", "l": "protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27706", "l": "ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.35", "l": "\"D-alanine--D-serine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75244", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50985", "l": "prostaglandin E2(out) => prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67852", "l": "FMNH2 + O2 = FMN-N(5)-peroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16468", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c553] <=> 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685953", "l": "SIRT6 deacetylates RBBP8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102584", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose = cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2430535", "l": "MASTL phosphorylates ENSA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62150", "l": "dGDP + dTDP => dGTP + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46669", "l": "21-hydroxyprogesterone + H(+) + NADPH => 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.183", "l": "\"taxoid 2alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937989", "l": "RUNX1 binds PRC1 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398184", "l": "LARG activation by G alpha 12/13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047294", "l": "phosphoglycerol geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72568", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) => dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.126", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23861", "l": "acetyl-CoA + deacetylcephalosporin C => cephalosporin C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0052834", "l": "inositol monophosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857345", "l": "Activated CEBPB binds CDKN2B promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613565", "l": "PRKAA2 dissociate from p-PLINs:HSPA8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086020", "l": "gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10955", "l": "(E)-sinapoyl-CoA + hydroxymalonate <=> (E)-sinapoyltartronate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398185", "l": "LARG binds plexin B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39220", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH => (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23092", "l": "H(+) + H2O + hydroxyatrazine = ethylamine + N-isopropylammelide", "d": [], "t": []}, {"i": "EC:3.5.4.43", "l": "\"hydroxydechloroatrazine ethylaminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388503", "l": "Oxytocin receptor bind oxytocin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004335", "l": "galactokinase activity", "d": ["Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57070", "l": "3-oxoisoapionate 4-phosphate + ADP + H(+) => 3-oxoisoapionate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229343", "l": "AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22955", "l": "O2 + octanedioyl-CoA <=> (2E)-octenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61400", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69575", "l": "dIMP + inosine <=> 2'-deoxyinosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62810", "l": "2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51287", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27590", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.44", "l": "\"pantoate--beta-alanine ligase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004760", "l": "serine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016993", "l": "precorrin-8X methylmutase activity", "d": ["Catalysis of the reaction: precorrin-8X = hydrogenobyrinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52529", "l": "2-oxoglutarate + L-asparagine => 2-oxosuccinamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22389", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine => CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52206", "l": "butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40750", "l": "2-oxoglutarate + L-lysine + O2 <=> (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690877", "l": "Expression of DMRT1 in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45053", "l": "(2E)-butenoyl-CoA + (R)-carnitine => CoA + O-(2E)-butenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74582", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] <=> N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193650", "l": "p75NTR binds to NADE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28074", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.308", "l": "\"sulfopropanediol 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61966", "l": "a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981621", "l": "Neuroglobin:oxygen dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16450", "l": "acetyl-CoA + kanamycin B => CoA + H(+) + N(6')-acetylkanamycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570528", "l": "SUMOylation of XPC with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50078", "l": "19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654224", "l": "Activated FGFR3 binds PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700156", "l": "Active ALK dimer binds IRS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12415", "l": "(2R)-3-phosphoglycerate + H2O <=> (R)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694409", "l": "Nucleotide exchange on RAB1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399952", "l": "Phosphorylation of LIMK-1 by PAK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69862", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38397", "l": "(9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47005", "l": "H2O + O-phospho-L-threonyl-[protein] => L-threonyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66889", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61605", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide => [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.146", "l": "\"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38616", "l": "cyclic ADP-beta-D-ribose + H2O => ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70481", "l": "TPI1 isomerizes GA3P to DHAP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43357", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) => cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395801", "l": "Phosphorylation of LAT by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650473", "l": "SERPING1 is secreted (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52510", "l": "13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65108", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] = aculene A + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791107", "l": "Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.260965879513137", "identifiers": [{"i": "GO:0022839", "l": "monoatomic ion-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56716", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] = H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23110", "l": "D-arabinonate + H(+) => D-arabinono-1,4-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30065", "l": "H(+) + menaquinol-8 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-8 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432054", "l": "Aquaporin-1 passively transports water out of cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026927", "l": "GGT hydrolyses RCTR1 to RCTR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71807", "l": "a 2'-deoxyguanosine in DNA + NAD(+) = an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917987", "l": "TFRC dimer binds 2xholoTF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73270", "l": "H(+)(out) + L-methionine(in) <=> H(+)(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32395", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12719", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11358", "l": "AH2 + NAD(+) => A + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62263", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) <=> 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59407", "l": "L-homoserine <=> D-homoserine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70029", "l": "H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine => N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52585", "l": "chenodeoxycholoyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31231", "l": "4-acetamidobutanal + H2O + NAD(+) = 4-acetamidobutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205321", "l": "Interaction of KIT and sSCF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35108", "l": "3-nitrotyramine + H2O + O2 => 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781840", "l": "ERCC6 binds stalled RNA Pol II (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29151", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.150", "l": "\"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61720", "l": "a D-guloside + NAD(+) = a 3-dehydro-D-guloside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60298", "l": "H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462014", "l": "Alpha-defensins form biologically active dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47131", "l": "ATP + CoA + deoxycholate <=> AMP + deoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018817", "l": "RHOT1 GEFs activate RHOT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047028", "l": "6-pyruvoyltetrahydropterin 2'-reductase activity", "d": ["Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13067", "l": "ADP + H(+) + phosphate => ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71695", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) = 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71672", "l": "glycyl-L-glutamine(out) + H(+)(out) => glycyl-L-glutamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49089", "l": "FAD + H(+) + H2O + squalene => FADH2 + hydroxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034817", "l": "cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71583", "l": "L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46096", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + dihydropinosylvin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55065", "l": "4-methylpentanoyl-CoA + H2O => 4-methylpentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55924", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39372", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983194", "l": "Kinesin-1 is a heterotetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60164", "l": "a guanosine in RNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69631", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24984", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60712", "l": "(+)-artemisinic alcohol + NAD(+) = (+)-artemisinic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24276", "l": "acetate + diphosphate = acetyl phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.7.2.12", "l": "\"acetate kinase (diphosphate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061501", "l": "2',3'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48465", "l": "a ganglioside GM1b + H2O => a ganglioside GA1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605717", "l": "GM2A binds and mobilizes ligands (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58629", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV => FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-982765", "l": "Growth hormone forms dimers and oligomers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17856", "l": "keto-L-sorbose + O2 <=> 5-dehydro-D-fructose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9770141", "l": "Formation of the Spliceosomal C* complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351478", "l": "Association of gamma-H2AX with MCPH1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64378", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2 => 8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30937", "l": "beta-D-ribosylnicotinate + phosphate => H2O + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41754", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45510", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30895", "l": "H2O + O2 + propane-1,3-diamine = 3-aminopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868608", "l": "Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849908", "l": "SALM4 binds flotillin-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656213", "l": "RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009974", "l": "zeinoxanthin epsilon hydroxylase activity", "d": ["Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11837", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14874", "l": "indole-3-ethanol + NAD(+) => H(+) + indole-3-acetaldehyde + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57058", "l": "D-apionolactone + H(+) + NADH => D-apiofuranose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14587", "l": "CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46246", "l": "(14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10905", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A => AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390929", "l": "HTR1 and 5A receptors can bind serotonin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34125", "l": "CoA + H(+) + olivetolate => 3,5,7-trioxododecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.39", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851908", "l": "Activated MET binds GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33798", "l": "H2O + sucrose <=> alpha-D-glucose + beta-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37755", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47406", "l": "3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050297", "l": "stizolobate synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63840", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide = [thioredoxin]-disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389862", "l": "Conversion of glyoxylate to oxalate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74932", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 => a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20959", "l": "2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29003", "l": "H(+)(out) + L-homoserine(in) = H(+)(in) + L-homoserine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32820", "l": "chromate(in) => chromate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46265", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754974", "l": "ADK phosphorylates RBV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033828", "l": "glucosylglycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13906", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629372", "l": "NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77438", "l": "a ganglioside GT1c + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GQ1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4647593", "l": "EP400 binds CDKN1A promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102610", "l": "(+)-secoisolariciresinol glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose = (+)-secoisolariciresinol monoglucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173680", "l": "Activation of C5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50336", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate = H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61905", "l": "betaenone A + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70062", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30207", "l": "H2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": [], "t": []}, {"i": "EC:1.4.9.1", "l": "\"methylamine dehydrogenase (amicyanin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64847", "l": "(2E)-geraniol + benzoyl-CoA <=> (2E)-geranyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215406", "l": "PRMT5 binds WDR77 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141035", "l": "CTP-dependent diacylglycerol kinase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30505", "l": "acetate + L-glutamate 5-semialdehyde => H2O + N-acetyl-L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865275", "l": "PDGF-BB clevage by Furin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008965", "l": "phosphoenolpyruvate-protein phosphotransferase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11069", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41025", "l": "1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317314", "l": "AKT binds PDPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19303", "l": "H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine => histamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047392", "l": "CMP-N-acylneuraminate phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29476", "l": "(2E,6E)-farnesyl diphosphate => (+)-cubenene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417829", "l": "P2RY12 binds ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45685", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) => N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63120", "l": "(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59400", "l": "L-2-aminohexanoate = D-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102852", "l": "1-18:3-2-16:0-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54453", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) => a uridine in tRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.7", "l": "\"methanol dehydrogenase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14128", "l": "2 raffinose <=> 1(F)-alpha-D-galactosylraffinose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47187", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869549", "l": "TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21565", "l": "acetyl-CoA + an acyl-CoA => a 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12193", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756603", "l": "SARS-CoV-1 S binds SFTPD 12mer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008912", "l": "lactaldehyde reductase activity", "d": ["Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+."], "t": []}, {"i": "EC:1.1.1.77", "l": "\"lactaldehyde reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432121", "l": "LDL binds to LRP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70242", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983422", "l": "Disassembly of COPII coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047104", "l": "hexadecanal dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + NAD+ + palmitaldehyde = H+ + NADH + palmitoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937034", "l": "IRAK1 phosphorylates Pellino (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174202", "l": "Degradation of multiubiquitinated Securin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102758", "l": "very-long-chain enoyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + NADP+ = a very-long-chain (2E)-enoyl-CoA + H+ + NADPH. This reaction is the fourth (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050337", "l": "thiosulfate-thiol sulfurtransferase activity", "d": ["Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45021", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018136", "l": "peptidyl-thiazoline dehydrogenase activity", "d": ["Catalysis of the reduction of a peptide-linked thiazoline to thiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75004", "l": "ATP + CoA + sulfoacetate => AMP + diphosphate + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76426", "l": "N-atom dealkylation of caffeine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34960", "l": "(R)-carnitine(in) => (R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23379", "l": "L-threonate + NAD(+) <=> 3-dehydro-D-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40809", "l": "(9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48581", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate => [pyruvate, water dikinase] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15981", "l": "H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}, {"i": "EC:4.1.1.50", "l": "\"adenosylmethionine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191072", "l": "Synthesis of Cx43 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66842", "l": "asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62233", "l": "a thymidine(6-4)thymidine in DNA => a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-874087", "l": "SGT1 binds HSP90 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20887", "l": "H2O + L-serine + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67332", "l": "13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77081", "l": "Formation of the CE:GMP intermediate complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51691", "l": "galactitol + NAD(+) <=> H(+) + keto-L-tagatose + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51226", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755600", "l": "Defective DOLK does not phosphorylate DCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46522", "l": "an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15653", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.105", "l": "\"6-phosphofructo-2-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69018", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3alpha-hydroxy-5beta-pregnan-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0050997", "l": "quaternary ammonium group binding", "d": ["Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60780", "l": "2-oxoglutarate + gibberellin A15 + O2 = CO2 + gibberellin A24 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45869", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0010465", "l": "nerve growth factor receptor activity", "d": ["Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822311", "l": "CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27474", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate => ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31105", "l": "folate + H(+) + NADPH => 7,8-dihydrofolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40785", "l": "CoA + docosanoate + H(+) => docosanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20902", "l": "benzyl alcohol + CO2 + glycine => H(+) + H2O + N-benzyloxycarbonylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004796", "l": "thromboxane-A synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23615", "l": "1,2-dihydro-alpha-santonin + NAD(+) <=> alpha-santonin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20854", "l": "ADP + 2 H(+)(out) + phosphate => ATP + H(+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65274", "l": "chrodrimanin H + H2O + NADP(+) => chrodrimanin C + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67381", "l": "H2O + L-alanyl-L-cysteine => L-alanine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869568", "l": "NPM1 binds TFAP2A homodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30923", "l": "(R)-glycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.268", "l": "\"glucosylglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72771", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102435", "l": "myricetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine = 7-O-methylmyricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46205", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814153", "l": "ADO oxidises 2AET to HTAU (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50053", "l": "ATP + H2O + taurocholate(in) => ADP + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57282", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA => a guanosine in RNA + glyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114544", "l": "p115-RhoGEF activation of RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648880", "l": "Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75093", "l": "2 chloride(out) + sulfate(in) => 2 chloride(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955869", "l": "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008414", "l": "CDP-alcohol phosphotransferase activity", "d": ["Catalysis of the transfer of a CDP-alcohol group from one compound to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167429", "l": "The receptor:G-protein complex  binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801195", "l": "STEAP3 binds BNIP3L (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28683", "l": "L-aspartate + ubiquinone-8 = iminosuccinate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32101", "l": "DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + TRIBOA beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47228", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18530", "l": "3-methylbutanol + NAD(+) => 3-methylbutanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34279", "l": "di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.94", "l": "\"polyprenol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23070", "l": "6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64838", "l": "CoA + phenethyl acetate => 2-phenylethanol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65742", "l": "CO2 + H(+) + nonanal + succinate + sulfate => 2-oxoglutarate + nonyl sufate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071164", "l": "RNA trimethylguanosine synthase activity", "d": ["Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69142", "l": "Recruitment of Dna2 endonuclease (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39453", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62780", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12743", "l": "IDP + NH4(+) => ADP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71541", "l": "H(+)(in) + 2 nitrate(in) => H(+)(out) + 2 nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20670", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043885", "l": "carbon-monoxide dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63639", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71686", "l": "2 H(+)(out) + L-aspartyl-glycine(out) <=> 2 H(+)(in) + L-aspartyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25779", "l": "scyllo-inosose <=> scyllo-inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59243", "l": "L-arginine + L-lysine <=> L-homoarginine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37974", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43860", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70481", "l": "TPI1 isomerizes GA3P to DHAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21250", "l": "diphosphate + RNA(n+1) => a ribonucleoside 5'-triphosphate + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169421", "l": "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.2", "l": "\"4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034841", "l": "mentha-1,3-dione-CoA ligase activity", "d": ["Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27498", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine => 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17313", "l": "ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": [], "t": []}, {"i": "EC:6.1.1.21", "l": "\"histidine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34277", "l": "3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine => 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24971", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635839", "l": "ULK3:SUFU dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782416", "l": "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878603", "l": "SSC5D binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990224", "l": "NMN phosphatase activity", "d": ["Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate."], "t": []}, {"i": "RHEA:30815", "l": "beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinamide D-riboside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862700", "l": "CMKLR1 binds Resolvin E1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26470", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate = 16-feruloyloxyhexadecanoate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.188", "l": "\"omega-hydroxypalmitate O-feruloyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004609", "l": "phosphatidylserine decarboxylase activity", "d": ["Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696266", "l": "RND2 binds effectors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65280", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51055", "l": "5alpha-androstan-3,17-dione + A <=> 5alpha-androst-1-ene-3,17-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33498", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate <=> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19082", "l": "1-haloalkane + H2O => a halide anion + a primary alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54717", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16453", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.34", "l": "\"4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.-", "l": "\"With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981610", "l": "Neuroglobin binds oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65881", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A => 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46445", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 => (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042809", "l": "nuclear vitamin D receptor binding", "d": ["Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40177", "l": "(2E)-octenoyl-CoA + H2O2 => O2 + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63498", "l": "4-nitrobenzyl alcohol + NADP(+) => 4-nitrobenzaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67149", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 => 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734687", "l": "ORC6 is phosphorylated on T195 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10846", "l": "L-aspartate + pyridoxal => oxaloacetate + pyridoxamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168280", "l": "Priming and Initiation of Transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48621", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814153", "l": "ADO oxidises 2AET to HTAU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0160041", "l": "neuropeptide activity", "d": ["The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58963", "l": "benzaldehyde + H2O + O2 <=> benzoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003953", "l": "NAD+ nucleosidase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022874", "l": "protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2423785", "l": "CR:atREs binds apoE and HSPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0016997", "l": "alpha-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66966", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22671", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + lipid A disaccharide (E. coli) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111264", "l": "Addition of nucleotides between position +11 and +30 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24550", "l": "a carboxylate + L-lysine => an N(6)-acyl-L-lysine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0036009", "l": "protein-glutamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine."], "t": []}, {"i": "REACT:R-HSA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11519", "l": "H2O + succinyl-CoA <=> CoA + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712201", "l": "GNAL exchanges GDP for GTP in odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67147", "l": "2-oxoglutarate + jasmonate + O2 <=> (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12153", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45838", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56657", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59952", "l": "2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57631", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate <=> H2O + ML-236C carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13934", "l": "all-trans-retinyl hexadecanoate + H2O => all-trans-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53551", "l": "prostaglandin J2 <=> Delta(12)-prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43605", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047055", "l": "salutaridine synthase activity", "d": ["Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76381", "l": "n H(+)(in) + L-histidine(in) => n H(+)(out) + L-histidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062154", "l": "N6-methyl-AMP deaminase activity", "d": ["Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028583", "l": "Phosphorylation of YAP by LATS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74731", "l": "rhamnetin + S-adenosyl-L-methionine = 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.-.-", "l": "\"Intramolecular oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50623", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430311", "l": "Rsu-1 interacts with Pinch1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169398", "l": "ISGylation of host protein filamin B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32223", "l": "(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788999", "l": "HV1-mediated H+ transfer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50515", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34160", "l": "acetyl-CoA + UDP-N-acetylbacillosamine => CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60084", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28351", "l": "UDP-beta-L-arabinofuranose => UDP-beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445705", "l": "Release Of ADP From Myosin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198347", "l": "AKT phosphorylates BAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52925", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047853", "l": "difructose-anhydride synthase activity", "d": ["Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950113", "l": "IL12A binds IL12B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828716", "l": "G mRNA is translated into membrane-bound G protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34862", "l": "3-oxocyclopentanecarbonitrile + 2 H2O <=> 3-oxocyclopentanecarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41015", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48493", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013693", "l": "NICD4 binds RBPJ and MAML in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44546", "l": "a fatty acid(in) + ADP + H(+) + phosphate => a fatty acid(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209566", "l": "TRAF6 is auto-ubiquitinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48578", "l": "3-chloro-cis,cis-muconate + 2 H(+) => 4-chlorocatechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49432", "l": "cholate + lithocholoyl-CoA = choloyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49240", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.193", "l": "\"protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62062", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22622", "l": "3-indoleglycolaldehyde + CO2 + NH4(+) => H(+) + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64931", "l": "dADP + H2O <=> dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24207", "l": "acetyl phosphate + H(+) + sulfite <=> phosphate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156682", "l": "PLK1 phosphorylates NUDC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39375", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA = (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187332", "l": "Cytosolic CMs translocate to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65649", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine => a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112690", "l": "PTPN11 binds CBL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120146", "l": "sulfatide binding", "d": ["Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + trichobrasilenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102859", "l": "1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming)", "d": ["Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52713", "l": "dTMP + H2O => 2-deoxy-D-ribose 5-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61495", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA <=> an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66664", "l": "ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37572", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66207", "l": "heptanoyl-CoA + O2 <=> (2E)-heptenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090541", "l": "MIT domain binding", "d": ["Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19114", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O => (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102711", "l": "gibberellin A25,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 = gibberellin A13 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199404", "l": "CD40L binds CD40 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198314", "l": "DAG stimulates protein kinase C-delta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32309", "l": "H2O + leukotriene A4 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11834", "l": "H(+) + NADH + naphthalene-1,2-diol => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034043", "l": "5-hydroxymethyluracil DNA N-glycosylase activity", "d": ["Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39014", "l": "a triacyl-sn-glycerol(in) <=> a triacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727188", "l": "ATP4A:ATP4B binds PPIs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58142", "l": "AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetyl-AMP + cytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052896", "l": "spermidine oxidase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermidine = 1,3-diaminopropane + 4-aminobutanal + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12922", "l": "glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38400", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74787", "l": "L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22942", "l": "ADP + H(+) + N(omega)-phospho-L-arginine => ATP + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36219", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74713", "l": "5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine => 5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36478", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388831", "l": "Phosphorylation of CD28 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848596", "l": "PTK6 binds PXN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34203", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = aureusidin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53349", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) => H(+) + NADH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67329", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione => trichosetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102563", "l": "aurachin C monooxygenase activity", "d": ["Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H = aurachin C epoxide + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58063", "l": "2-sulfinoacetaldehyde + H2O <=> acetaldehyde + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22853", "l": "L-serine + pyruvate => 3-hydroxypyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448744", "l": "IL20RA binds IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318585", "l": "Defective HYAL1 does not hydrolyse Chondroitin chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693061", "l": "STAMBP binds STAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48906", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21051", "l": "ATP + isopropylamine + L-glutamate <=> ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73788", "l": "dimethylallyl diphosphate + tardioxopiperazine A => diphosphate + variecolorin L", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71712", "l": "H(+)(out) + L-tyrosylglycine(out) => H(+)(in) + L-tyrosylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64017", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627775", "l": "Autophosphorylation of PAK1,2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41228", "l": "(S)-4-hydroxymandelate + O2 => 4-hydroxyphenylglyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33718", "l": "4-hydroxyeicosasphinganine 1-phosphate <=> 2-hydroxyoctadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51630", "l": "CO2 + dUTP + H2O => formate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68763", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48059", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> beta-D-glucosylceramide + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53043", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004462", "l": "lactoylglutathione lyase activity", "d": ["Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69757", "l": "(E)-2-aminocinnamoyl-CoA + CO2 + H2O2 => (2-aminobenzyl)malonyl-CoA + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69142", "l": "Recruitment of Dna2 endonuclease (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74233", "l": "L-threonine + tRNA(Val) => H2O + L-threonyl-tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37371", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.23", "l": "\"beta-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62421", "l": "a (R)-2-hydroxy fatty acid + O2 => a fatty acid + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58738", "l": "5-methyl-UMP + diphosphate + H(+) => H2O + TTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29873", "l": "ADP + H(+) + phosphate + thiosulfate(in) => ATP + H2O + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55729", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395801", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58981", "l": "citral + H2O + O2 => 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42368", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.124", "l": "\"dihydromonacolin L hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23755", "l": "all-trans-undecaprenol + ATP <=> ADP + all-trans-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30104", "l": "2,5-didehydro-D-gluconate + H(+) + NADH => 5-dehydro-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111924", "l": "PKA catalytic subunit translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031005", "l": "filamin binding", "d": ["Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68574", "l": "L-tyrosine(out) => L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75712", "l": "a rhodoquinone + succinate => a rhodoquinol + fumarate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76877", "l": "H(+) + hexan-2-one + NADH + NH4(+) => H2O + hexan-2-amine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264458", "l": "Proteasome mediated degradation of COP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39120", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323184", "l": "Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35105", "l": "fusidate(out) => fusidate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35918", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340214", "l": "CYGB binds O2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10814", "l": "2 H(+) + N-succinyl-L-glutamate + NADH => H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43679", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70340", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050370", "l": "tyrosine N-monooxygenase activity", "d": ["Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73715", "l": "ATP(in) + dATP(out) = ATP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57239", "l": "GMP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76779", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,6-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163402", "l": "diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47236", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12547", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428260", "l": "DEGS2 oxygenates dihydroceramide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928656", "l": "gamma-secretase cleaves EPHB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50564", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33280", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981728", "l": "Factor H binds to membrane-associated C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16376", "l": "(R)-pantothenate + ATP <=> (R)-4'-phosphopantothenate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35722", "l": "(3S)-versiconol acetate + H2O <=> (S)-versiconol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41738", "l": "adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) => 3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51793", "l": "H(+) + NADH + O2 + salicylate => 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050373", "l": "UDP-arabinose 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65486", "l": "CoA + hexyl hexanoate => hexan-1-ol + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44608", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50484", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029445", "l": "An unknown GEF exchanges GTP for GDP on CDC42:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614369", "l": "Transport of HCMV DNA Into the Nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53368", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) = H(+) + NADPH + uridine(17) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22288", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.123", "l": "\"endoglycosylceramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23786", "l": "(S)-1-pyrroline-5-carboxylate + a quinol + H(+) => a quinone + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532549", "l": "MPI isomerises Fru6P to Man6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51162", "l": "5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42885", "l": "(R)-mevalonate + ATP => (R)-3-phosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31726", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22334", "l": "2-methylmaleate + H2O => (3R)-citramalate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30797", "l": "CO2 + glutaryl-CoA + NADH => 2-oxoadipate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54791", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.4", "l": "\"glucose oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603407", "l": "Activated NTRK3 binds PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53533", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13782", "l": "an L-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16337", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.82", "l": "\"flavonoid 3'-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15906", "l": "3-hydroxycyclohexanone + A => AH2 + cyclohexane-1,3-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005522", "l": "profilin binding", "d": ["Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60234", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653886", "l": "B4GALT1 binds LALBA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57979", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside C-K + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45961", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22344", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA = (R)-rosmarinate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.140", "l": "\"rosmarinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58135", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14445", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008265", "l": "Mo-molybdopterin cofactor sulfurase activity", "d": ["Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15478", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol => 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44936", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57120", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684006", "l": "KPNA2 translocates NBN to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30965", "l": "7,7',9,9'-tetra-cis-lycopene + a quinol => 7,9,9'-tri-cis-neurosporene + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23226", "l": "H(+) + O-beta-D-glucosyl-trans-zeatin + UDP => trans-zeatin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17120", "l": "ATP + L-glutamate + methylamine <=> ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679239", "l": "ULK complex translocates to the ER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004794", "l": "threonine deaminase activity", "d": ["Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726875", "l": "HCNs:cAMP bind SNIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37291", "l": "H2O + L-alanyl-L-leucine = L-alanine + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53872", "l": "CTP + D-ribose 5-phosphate + H(+) = CDP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52297", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28474", "l": "D-glucarate(in) + H(+)(in) = D-glucarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62093", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65289", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23392", "l": "(n-1) H2O + RNA(n) = n a ribonucleoside 5'-phosphate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687107", "l": "MAPK4,6 translocate to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37326", "l": "glycyl-L-methionine + H2O <=> glycine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12032", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.77", "l": "\"acyloxyacyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52940", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660503", "l": "Expression of CSRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70403", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine = CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12645", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.8", "l": "\"indolepyruvate ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814387", "l": "CASP14 cleaves filaggrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26311", "l": "1,4-dihydroxy-2-naphthoate + CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103006", "l": "9,10-dihydroxystearate hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH = 9,10,18-trihydroxystearate + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654422", "l": "Activated FGFR4 binds FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451347", "l": "Activation of JNK by DSCAM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43404", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26561", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19500", "l": "H(+) + L-aspartate <=> beta-alanine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57519", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51876", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111970", "l": "PKC phosphorylates GRK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388468", "l": "AVP(20-28) binds AVPR1A,B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47970", "l": "a ganglioside GM3 + N-acetyl-beta-D-galactosamine => a ganglioside GM2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57311", "l": "CTP + H(+) + N(5)-phospho-L-glutamine <=> diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562541", "l": "TLR4-induced ripoptosome assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65225", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212651", "l": "Transport of L-Glutamine (cytosol) to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48475", "l": "a ganglioside GT1a + H2O <=> a ganglioside GD1a + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64095", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982637", "l": "Opsins binds G alpha-t (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34187", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20828", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.65", "l": "\"phosphatidylserine decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64926", "l": "dAMP + 2 H(+) + 2 phosphate => dATP + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28260", "l": "cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41056", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801762", "l": "REG3A oligomerize to form a pore complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003714", "l": "transcription corepressor activity", "d": ["A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59378", "l": "4-amino-4-deoxyprephenate => 4-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17836", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine <=> 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373745", "l": "SDK1 homophillic interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174235", "l": "Association of Emi1 with Cdc20 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29880", "l": "ATP + H2O + L-arginine(out) => ADP + H(+) + L-arginine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28394", "l": "L-alanyl-L-glutamate = L-alanyl-D-glutamate", "d": [], "t": []}, {"i": "EC:5.1.1.20", "l": "\"L-Ala-D/L-Glu epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35794", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin X + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13697", "l": "ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.15", "l": "\"ribokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32475", "l": "glycine + 3 S-adenosyl-L-methionine = glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.162", "l": "\"glycine/sarcosine/dimethylglycine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253343", "l": "WWOX binds ERBB4s80 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35475", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955844", "l": "RBKS phosphorylates ribose to R5P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986294", "l": "RUNX2 binds GLI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71472", "l": "H2O + substance P => L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102332", "l": "fatty-acyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46415", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38501", "l": "a 2,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73905", "l": "ADP + gamma-L-glutamylethanolamide + H(+) + phosphate => ATP + ethanolamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67580", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate = adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050451", "l": "CoA-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: 2 CoA + NADP+ = CoA-disulfide + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174624", "l": "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42712", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.35", "l": "\"tRNA (uracil(54)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690740", "l": "CD22 binds B-cell receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74726", "l": "Dissociation of insulin from insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53733", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate => 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27591", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20570", "l": "H2O + L-arginine => L-ornithine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395412", "l": "Phosphorylation of SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29144", "l": "a ubiquinol + 2 H(+)(in) + nitrate => a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66391", "l": "ATP + H2O + prostaglandin E2(in) <=> ADP + H(+) + phosphate + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60172", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757954", "l": "N4BP1 binds IKBKG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38671", "l": "sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445067", "l": "NrCAM binds axonin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33009", "l": "(+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61077", "l": "(-)-minovincinine + acetyl-CoA => (-)-echitovenine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36529", "l": "(13Z)-3-oxodocosenoyl-CoA + CO2 + CoA => (11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0045290", "l": "D-arabinose 1-dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49096", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": [], "t": []}, {"i": "EC:1.21.98.3", "l": "\"anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0004879", "l": "nuclear receptor activity", "d": ["A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29499", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.69", "l": "\"(+)-alpha-barbatene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55646", "l": "ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate => ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54671", "l": "pre-alpha-onocerin <=> alpha-onocerin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30526", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 <=> GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32077", "l": "(13E)-labda-7,13-dien-15-ol + diphosphate => geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380294", "l": "Loss of C-Nap-1 from centrosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31209", "l": "(2E)-hexenoyl-CoA + FADH2 => FAD + H(+) + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55718", "l": "(9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140396", "l": "5'-hydroxyaverantin dehydrogenase activity", "d": ["Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68941", "l": "Na(+)(in) + tellurite(in) => Na(+)(out) + tellurite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62651", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928646", "l": "EPHAs bind EFNAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75759", "l": "(9Z,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40108", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200396", "l": "Creatine transport across the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196026", "l": "Dab2 is recruited to the junctional plaques (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262775", "l": "Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23408", "l": "NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A", "d": [], "t": []}, {"i": "EC:1.3.1.54", "l": "\"precorrin-6A reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70746", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64355", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809663", "l": "Formation of hair keratin fibres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19408", "l": "acetyl-CoA + citrate <=> (3S)-citryl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21422", "l": "15-dehydro-prostaglandin I2 + H(+) + NADPH => NADP(+) + prostaglandin I2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392263", "l": "AVP(20-28) binds AVPR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209536", "l": "IkB is ubiquitinated and degraded (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762343", "l": "PREDL:ALB dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55845", "l": "calcidiol + UDP-alpha-D-glucuronate => calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.26", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31547", "l": "2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.96", "l": "\"4,4'-diapophytoene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34913", "l": "D-methionine(out) => D-methionine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003972", "l": "RNA ligase (ATP) activity", "d": ["Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49091", "l": "FAD + H(+) + H2O + squalene <=> FADH2 + hydroxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75630", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O <=> ectocarpin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55360", "l": "11-cis-retinol = 9-cis-retinol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030883", "l": "endogenous lipid antigen binding", "d": ["Binding to an endogenous cellular lipid antigen."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.23", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.236", "l": "\"NAD(+) 3'-kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71322", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) <=> chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42034", "l": "2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12455", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917730", "l": "Cargo Recognition And Sorting (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35276", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) => 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59179", "l": "ADP + L-serine <=> AMP + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46567", "l": "acetyl-CoA + apo-[ACP] <=> acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140757", "l": "cysteine-type deNEDDylase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37908", "l": "(9Z)-octadecenoate + O2 => (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031625", "l": "ubiquitin protein ligase binding", "d": ["Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802925", "l": "Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168136", "l": "Activated JNKs phosphorylate c-JUN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172194", "l": "Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868118", "l": "MAPK12 phosphorylates PTPN3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836270", "l": "TFAP2A binds TFAP2C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371518", "l": "SIRT1 binds to HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30144", "l": "H2O + octanoyl-CoA => CoA + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205286", "l": "GRB2:SOS interacts with p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48740", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.113", "l": "\"[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8863727", "l": "STON2 is neddylated (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43896", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0016300", "l": "tRNA (uridine) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12892", "l": "L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72228", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) => chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72222", "l": "3 hydrogencarbonate(out) + Na(+)(out) <=> 3 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71723", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) = H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60844", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382057", "l": "Release of novel PDGFs as latent factors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50718", "l": "FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate => dimethyl sulfone + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952996", "l": "E2F7 forms homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40103", "l": "H2O + propanoyl-CoA = CoA + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.31", "l": "\"sulfoquinovose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75849", "l": "9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37567", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815510", "l": "MIB2 binds CYLD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76811", "l": "(S)-methioninol + H2O + NAD(+) = 1-hydroxy-4-(methythio)butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031872", "l": "type 1 proteinase activated receptor binding", "d": ["Binding to a type 1 proteinase activated receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617182", "l": "PRKACA phosphorylates PLN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004747", "l": "ribokinase activity", "d": ["Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "54.043062259302353", "identifiers": [{"i": "GO:0015079", "l": "potassium ion transmembrane transporter activity", "d": ["Enables the transfer of potassium ions (K+) from one side of a membrane to the other."], "t": []}, {"i": "RHEA:29463", "l": "K(+)(in) = K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805276", "l": "CDK5 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70692", "l": "ornithine => putrescine + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69068", "l": "RFC dissociates after sliding clamp formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19950", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate => 7,8-dihydropteroate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416562", "l": "p190RhoGAP binds Plexin-B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198611", "l": "AKT phosphorylates IKKalpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60132", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53745", "l": "glycyl-tRNA(Ala) + H2O => glycine + H(+) + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63835", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine <=> capsaicin + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10941", "l": "(2E)-geranyl diphosphate => (4R)-limonene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16174", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine => (S)-norcoclaurine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63870", "l": "(2R,9Z)-2-hydroperoxyoctadecenoate => (9Z)-octadecenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12597", "l": "acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin", "d": [], "t": []}, {"i": "EC:2.3.1.183", "l": "\"phosphinothricin acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32133", "l": "butanoyl-CoA + CO2 => (2S)-ethylmalonyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668395", "l": "CHMP7 binds CC2D1B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27898", "l": "3'-AMP + H2O = adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018501", "l": "cis-chlorobenzene dihydrodiol dehydrogenase activity", "d": ["Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22544", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64375", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O <=> alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61456", "l": "7-chlorotetracycline + H(+) + NADPH + O2 = (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35943", "l": "brevianamide F + dimethylallyl diphosphate = deoxybrevianamide E + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.109", "l": "\"brevianamide F prenyltransferase (deoxybrevianamide E-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72209", "l": "chloride(in) + 2 hydrogencarbonate(out) => chloride(out) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13331", "l": "a 3-oxo-Delta(1)-steroid + AH2 => A + a 3-oxosteroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15145", "l": "D-maltose = alpha,alpha-trehalose", "d": [], "t": []}, {"i": "EC:5.4.99.16", "l": "\"maltose alpha-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63058", "l": "5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66576", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol = 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55495", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.78", "l": "\"phosphopolyprenol glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769316", "l": "NPAS4 binds NAMPT gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35434", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004604", "l": "phosphoadenylyl-sulfate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73082", "l": "S-adenosyl-L-methionine + scutellarein <=> S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043765", "l": "T/G mismatch-specific endonuclease activity", "d": ["Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855188", "l": "IP6 transports from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070996", "l": "type 1 melanocortin receptor binding", "d": ["Binding to a type 1 melanocortin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654571", "l": "Activated FGFR1 binds FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55105", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58547", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21750", "l": "H(+) + methylglyoxal + NADPH => (S)-lactaldehyde + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12898", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21083", "l": "ATP + H2O + L-methionine <=> diphosphate + phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72675", "l": "3',5'-cyclic CMP + H2O = CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42907", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68435", "l": "lutein + O2 <=> (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.63", "l": "\"3-hydroxyphenylacetate 6-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77608", "l": "Binding of A1CF to stem-looped RNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237160", "l": "MTA is cleaved and phosphorylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732527", "l": "FFAR1 binds rosiglitazone (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65347", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA <=> (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49036", "l": "(-)-pluviatolide + S-adenosyl-L-methionine = (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.323", "l": "\"(-)-pluviatolide 4-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340226", "l": "CYGB dioxygenates NO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20617", "l": "L-galactono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate", "d": [], "t": []}, {"i": "EC:1.3.3.12", "l": "\"L-galactonolactone oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140598", "l": "lipoprotein carrier activity", "d": ["Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070774", "l": "phytoceramidase activity", "d": ["Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322434", "l": "XIAP dissociates from ub-TLE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166015", "l": "Association of LBP with LPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676596", "l": "TRAF3 binds BAFFR:BAFF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76748", "l": "hexadecane + O2 + reduced [NADPH--hemoprotein reductase] => 9-hexadecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55782", "l": "all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39429", "l": "(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182198", "l": "Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701064", "l": "TRPV1 binds TRPV1 agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022314", "l": "HIPK2 phosphorylates MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22747", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42970", "l": "2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(56) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004144", "l": "diacylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25808", "l": "H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41251", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64514", "l": "6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => (3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41163", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP = 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25452", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000319", "l": "BORA binds PLK1 and AURKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001646", "l": "cAMP receptor activity", "d": ["Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55131", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] <=> (2E)-5-methylhexenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420233", "l": "VIP receptors bind VIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53549", "l": "prostaglandin J2 => Delta(12)-prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37535", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36181", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187632", "l": "arginine + H2O => ornithine + urea (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59008", "l": "H2O + O2 + salicylaldehyde = H(+) + H2O2 + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62386", "l": "(2R)-2,3-bisphosphoglycerate + 2 H(+) => cyclic (2R)-2,3-bisphosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64577", "l": "2 Fe(III)-[cytochrome b5] + NADPH => 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33218", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76098", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48701", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72291", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) = 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43917", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.7", "l": "\"phosphopentomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015561", "l": "rhamnose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)."], "t": []}, {"i": "TCDB:2.A.7.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16634", "l": "guanosine(34) in tRNA + queuine => guanine + queuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20524", "l": "(R)-3-hydroxybutanoate + NAD(+) <=> acetoacetate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61794", "l": "diphosphate + L-tryptophyl-5'-AMP => ATP + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018722", "l": "1-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19076", "l": "ATP + L-seryl-[I-kappa-B protein] <=> ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27943", "l": "(3R)-3-hydroxy-D-aspartate => NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66534", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828028", "l": "Expression of CXCR4 in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13719", "l": "1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH => 2-C-methyl-D-erythritol 4-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14512", "l": "2-oxoglutarate + mugineate + O2 <=> 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047680", "l": "aryl-acylamidase activity", "d": ["Catalysis of the reaction: anilide + H2O = a carboxylate + aniline + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3779381", "l": "H2O2 diffuses from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.14", "l": "\"methyl-branched lipid omega-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983422", "l": "Disassembly of COPII coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708866", "l": "pro-F2R binds vorapaxar (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28216", "l": "[thioredoxin]-disulfide + prostaglandin F2alpha => [thioredoxin]-dithiol + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676071", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73547", "l": "GTP(out) + UTP(in) = GTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008753", "l": "NADPH dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69300", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = benzyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072555", "l": "17-beta-ketosteroid reductase activity", "d": ["Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40872", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) => (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35672", "l": "(S)-5'-oxoaverantin + H(+) => (1'S,5'S)-averufin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799350", "l": "Exocytosis of specific granule membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22268", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 6-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.72", "l": "\"streptomycin 6-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0042826", "l": "histone deacetylase binding", "d": ["Binding to histone deacetylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51025", "l": "H(+) + NADH + O2 + toluene-4-sulfonate => 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607721", "l": "Activation of NIK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29982", "l": "2'-deoxyadenosine(in) + H(+)(in) <=> 2'-deoxyadenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38922", "l": "H2O + sphing-4-enine-phosphocholine <=> choline + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043876", "l": "D-threonine aldolase activity", "d": ["Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005052", "l": "peroxisome matrix targeting signal-1 binding", "d": ["Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718020", "l": "PTGFR binds PTGFR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070497", "l": "6-carboxy-5,6,7,8-tetrahydropterin synthase activity", "d": ["Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768832", "l": "SRF binds NPAS4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72631", "l": "Formation of the cap-binding eIF4F complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798081", "l": "TP53 family members stimulate CASP1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27860", "l": "3'-GMP + H(+) => 2',3'-cyclophospho-GMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507870", "l": "Aquaporins passively transport water out of cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112727", "l": "Serine phosphorylation of STATs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72509", "l": "2-oxoglutarate(out) + prostaglandin F2alpha(in) => 2-oxoglutarate(in) + prostaglandin F2alpha(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008475", "l": "procollagen-lysine 5-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51193", "l": "(R)-2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36611", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.3", "l": "\"(5R)-carbapenem-3-carboxylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607023", "l": "factor IXa associates with cell membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68720", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022851", "l": "GABA-gated chloride ion channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036169", "l": "3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity", "d": ["Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2."], "t": []}, {"i": "REACT:R-HSA-2162195", "l": "MHDB is decarboxylated to DMPhOH by MHDB decarboxylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2314686", "l": "ASA- acetylates PTGS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668735", "l": "RAC1:GTP binds NOX3 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705584", "l": "HMGCR dimer binds statins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18531", "l": "3-methylbutanal + H(+) + NADH => 3-methylbutanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56197", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30439", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}, {"i": "EC:2.3.2.17", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70505", "l": "H(+) + isopentenyl phosphate + phosphate => H2O + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141341", "l": "SMOX-3 oxidises SPN to SPM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28679", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70988", "l": "beta-alanine(out) + n H(+)(in) => beta-alanine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029273", "l": "PI3K binds to p-6Y-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25227", "l": "H(+) + L-arabinose + NADH => L-arabinitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44999", "l": "(R)-carnitine + acetoacetyl-CoA <=> CoA + O-3-oxobutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22729", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57044", "l": "D-apionate + NAD(+) = 3-oxoisoapionate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.421", "l": "\"D-apionate oxidoisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008296", "l": "3'-5'-DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule."], "t": []}, {"i": "REACT:R-HSA-9023943", "l": "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66507", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29324", "l": "fumarate(in) + succinate(out) => fumarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73596", "l": "dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19361", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.10", "l": "\"(2E,6E)-farnesyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018758", "l": "RHOH binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20278", "l": "acetyl-CoA + an N-hydroxyarylamine => an N-acetoxyarylamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16249", "l": "alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.15", "l": "\"glucose-6-phosphate 1-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40625", "l": "2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate => H2O + tritetradecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.54", "l": "\"UDP-2,3-diacylglucosamine diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26446", "l": "3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.75", "l": "\"malonyl CoA reductase (malonate semialdehyde-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008215", "l": "RUNX2 binds GLI3R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983424", "l": "Budding of COPII coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52318", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41097", "l": "H(+) + phosphocholine + sphing-4-enine => H2O + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139842", "l": "Binding of Syk tyrosine kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30827", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63074", "l": "4 CO2 + 4 CoA + orcinol => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25661", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103097", "l": "CYP79F1 trihomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50909", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 => A + a 3-demethylubiquinol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54720", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662986", "l": "MT2A binds copper (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030374", "l": "nuclear receptor coactivator activity", "d": ["A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52304", "l": "H2O + L-ectoine = (2S)-2-acetamido-4-aminobutanoate", "d": [], "t": []}, {"i": "EC:3.5.4.44", "l": "\"ectoine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52523", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21883", "l": "2 H(+) + O2 + oxalate <=> 2 CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685838", "l": "CX3 complex binds D-loop structures (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350651", "l": "Caspase-mediated cleavage of MASK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106435", "l": "carboxylesterase activity", "d": ["Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.20", "l": "\"carboxypeptidase U\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672159", "l": "STAT binds to p-11Y PDGFRA extracellular domain dimers  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26181", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65805", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15345", "l": "ATP + L-arginine + L-tyrosine = AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": [], "t": []}, {"i": "EC:6.3.2.24", "l": "\"tyrosine--arginine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49238", "l": "L-histidyl-[protein] + sucrose 6(G)-phosphate(in) => N(pros)-phospho-L-histidyl-[protein](out) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77187", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702578", "l": "semaxanib-resistant FLT3 mutants don't bind semaxanib<br> (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003921", "l": "GMP synthase activity", "d": ["Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391372", "l": "GNRHR binds GNRH1,2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56508", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43814", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54775", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952419", "l": "SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001850", "l": "complement component C3a binding", "d": ["Binding to a C3a product of the complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55518", "l": "11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64276", "l": "chrysophanol-9-anthrone + O2 = chrysophanol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0141054", "l": "histone H2B ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H2B substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49479", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) <=> H(+) + L-2-aminoadipate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30843", "l": "H2O + N-formylmaleamate = formate + H(+) + maleamate", "d": [], "t": []}, {"i": "EC:3.5.1.106", "l": "\"N-formylmaleamate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20105", "l": "ADP + beta-D-fructose 6-phosphate = AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.146", "l": "\"ADP-specific phosphofructokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.6", "l": "\"leucolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62046", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52105", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68648", "l": "2 L-cysteine = H(+) + hydrogen sulfide + L-lanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56751", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373748", "l": "SEMA4D interacts with CD72 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27352", "l": "arsenate + mycothiol <=> arseno-mycothiol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225947", "l": "Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56728", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 = 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74379", "l": "2 (S)-lactate(in) + prostaglandin H2(out) = 2 (S)-lactate(out) + prostaglandin H2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694522", "l": "Inner coat assembly and cargo binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75151", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + neoverrucosan-5beta-ol", "d": [], "t": []}, {"i": "EC:4.2.3.207", "l": "\"neoverrucosan-5beta-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10801", "l": "diphosphate + XMP => 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034940", "l": "5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity", "d": ["Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19398", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine => CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57888", "l": "a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16203", "l": "4-aminobenzoate + H(+) + pyruvate => 4-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0003993", "l": "acid phosphatase activity", "d": ["Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191299", "l": "Squalene is oxidized to its epoxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668714", "l": "RAC1:GTP binds NOX1 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37667", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.313", "l": "\"protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.5", "l": "\"cathepsin D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13169", "l": "maleate = fumarate", "d": [], "t": []}, {"i": "EC:5.2.1.1", "l": "\"maleate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46859", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10601", "l": "prostaglandin H2 => prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14371", "l": "glycolate + phosphate => 2-phosphoglycolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37345", "l": "adenosine + phosphate => adenosine 2'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864569", "l": "WWOX binds TFAP2C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38398", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44623", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863463", "l": "STON2 binds SYT proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41092", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49135", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008609", "l": "alkylglycerone-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46438", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388817", "l": "ICOS binds ICOSL/B7-H2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53616", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.157", "l": "\"(+)-isoafricanol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60955", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine <=> (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614614", "l": "Cysteine is degraded to serine and H2S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10868", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.20", "l": "\"diacylglycerol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42111", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51248", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47304", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71312", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) => chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59276", "l": "L-glutamine = D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179413", "l": "Activated PKC-alpha  activate MMP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50585", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) => 15-oxoprostaglandin E1 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.9", "l": "\"ferric-chelate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16202", "l": "4-amino-4-deoxychorismate => 4-aminobenzoate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036042", "l": "long-chain fatty acyl-CoA binding", "d": ["Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49144", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.110", "l": "\"dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.9", "l": "\"trypanothione synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853429", "l": "PHLDA1 binds AURKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36261", "l": "an aldehyde + glycerol => a 1-(1-hydroxyalkyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17542", "l": "an aromatic primary alcohol + O2 => an aromatic aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673223", "l": "FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875661", "l": "GGA3 associates with activated MET receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727886", "l": "SARS-CoV-1 SUMO-p-N binds to NPM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381087", "l": "Dimerization of PERK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404144", "l": "Parenchymal atROL translocates to HSCs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75907", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] = ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036435", "l": "K48-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein."], "t": []}, {"i": "REACT:R-HSA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0004602", "l": "glutathione peroxidase activity", "d": ["Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102924", "l": "gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018450", "l": "myrtenol dehydrogenase activity", "d": ["Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28840", "l": "H(+)(out) + Zn(2+)(in) => H(+)(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0016663", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.7.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756470", "l": "N binds to heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19999", "l": "phosphate + pyruvate => H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39483", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77027", "l": "D-serine + H2O + NAD(+) = 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33487", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA = CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42486", "l": "D-sorbitol 6-phosphate(in) + L-histidyl-[protein] => D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69773", "l": "a short-chain fatty acid + 2 H(+) + NADH => a short-chain fatty aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854209", "l": "TBC1D10A binds JFC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20394", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine => (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70477", "l": "2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23648", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12292", "l": "ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69446", "l": "alpha-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37058", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate <=> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.69", "l": "\"glycosphingolipid deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195251", "l": "Assembly of the destruction complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38402", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47585", "l": "a ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose => a ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980039", "l": "NOTCH1 binds DLL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140797", "l": "histone H3R17 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59984", "l": "an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35762", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33789", "l": "3-keto-beta-D-galactose + beta-D-glucose => 3'-ketolactose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004459", "l": "L-lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54321", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22452", "l": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.10", "l": "\"endopolyphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13796", "l": "2-methyleneglutarate <=> 2-methylene-3-methylsuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67034", "l": "4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14946", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29549", "l": "2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11592", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": [], "t": []}, {"i": "EC:3.1.2.31", "l": "\"dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37347", "l": "(R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate", "d": [], "t": []}, {"i": "EC:6.1.2.1", "l": "\"D-alanine--(R)-lactate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23009", "l": "alpha,alpha-trehalose 6-phosphate + H2O => D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60057", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668831", "l": "CST complex formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34967", "l": "sn-glycerol 3-phosphate(in) = sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10869", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0046993", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen."], "t": []}, {"i": "EC:1.21.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0072374", "l": "carotene epsilon hydroxylase activity", "d": ["Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68954", "l": "Mcm2-7 is phosphorylated by DDK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63030", "l": "(15Z)-tetracosenoate + NH4(+) => (15Z)-tetracosenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44777", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine => H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029273", "l": "PI3K binds to p-6Y-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209921", "l": "Monoiodinated tyrosine can be deiodinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56676", "l": "dihydroferuloyl-CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44612", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71775", "l": "acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58127", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617483", "l": "HOXA2 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603598", "l": "BAX activation is stimulated by NTRK3(495-641) and NELFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033771", "l": "flavanone 2-hydroxylase activity", "d": ["Catalysis of the reaction: a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41370", "l": "1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25078", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45119", "l": "(4R)-ipsdienol + NADP(+) <=> H(+) + ipsdienone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0043531", "l": "ADP binding", "d": ["Binding to ADP, adenosine 5'-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.86", "l": "\"ADAM 17 endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62879", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate <=> A + semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70349", "l": "3-bromo-L-tyrosine + NADPH => bromide + L-tyrosine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16698", "l": "A + H2O + quinaldate => AH2 + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45346", "l": "a globoside NORint (d18:1(4E)) + H(+) + UDP => a globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864577", "l": "TFAP2C translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209973", "l": "Tyrosine is diiodinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65151", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + trilobatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.57", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42689", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide => A + ergothioneine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050681", "l": "nuclear androgen receptor binding", "d": ["Binding to a nuclear androgen receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33124", "l": "all-trans-heptaprenyl diphosphate => (R)-tetraprenyl-beta-curcumene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374899", "l": "Release of noradrenaline  at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39469", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981657", "l": "IL34 dimer binds PTPRZ1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004398", "l": "histidine decarboxylase activity", "d": ["Catalysis of the reaction: L-histidine = histamine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176956", "l": "Formation of GINS complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76606", "l": "(12Z)-10-hydroxyoctadecenoate + H2O <=> 10,13-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48775", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a <=> 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51840", "l": "2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) + tauroallocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77348", "l": "L-alanine + oxaloacetate => L-aspartate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034943", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "d": ["Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653936", "l": "Formation of Ragulator complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51622", "l": "CO2 + dCTP + H2O => CTP + formate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27966", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate", "d": [], "t": []}, {"i": "EC:4.1.2.50", "l": "\"6-carboxytetrahydropterin synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755734", "l": "SARS-CoV-2 N binds IKBKB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848873", "l": "PTK6 phosphorylates ARAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18573", "l": "dihydrochelirubine + H(+) + O2 = chelirubine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50601", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39847", "l": "a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45793", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 => [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008793", "l": "aromatic-amino-acid:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12008", "l": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.11.16", "l": "\"[G-protein-coupled receptor] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373141", "l": "malate <=> fumarate + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15447", "l": "CO2 + 2 NH4(+) + pyruvate => H(+) + H2O + O-carbamoyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.67", "l": "\"choriolysin H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36939", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA = (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34738", "l": "a fatty acyl-CoA + sphinganine <=> an N-acylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.10", "l": "\"carboxypeptidase E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76488", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10386", "l": "beta-cyclopiazonate + diphosphate => cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75110", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45116", "l": "(4R)-ipsdienol + NADP(+) = H(+) + ipsdienone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25700", "l": "(E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-hexahomomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40633", "l": "2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate => H2O + trioctadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26483", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate => diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42228", "l": "17beta-estradiol + A = AH2 + estrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665871", "l": "ADRM1 binds 26S proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043783", "l": "oxidoreductase activity, acting on metal ions, flavin as acceptor", "d": ["Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor."], "t": []}, {"i": "EC:1.16.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64729", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332236", "l": "CBL neddylates TGFBR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75547", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH = (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21541", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37054", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404142", "l": "atROL binds RBP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44026", "l": "(2E)-dodecenoyl-CoA + H2O => (3R)-3-hydroxydodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34043", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine = 5''-phosphoribostamycin + diphosphate", "d": [], "t": []}, {"i": "EC:2.4.2.49", "l": "\"neamine phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66022", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20020", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 <=> 5,10-methylenetetrahydromethanopterin + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49269", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46841", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39960", "l": "1-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865482", "l": "KMT2A (MLL) binds RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264865", "l": "Caspase-mediated cleavage of Lamin A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428273", "l": "SPHK1 phosphorylates sphingoid (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20036", "l": "isopenicillin N <=> penicillin N", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944262", "l": "Association of procollagen type X (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74704", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] => 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209960", "l": "Diiodinated tyrosine can be deiodinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382053", "l": "Translocation of PDGF from ER to Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68966", "l": "2-oxooctadecanoate + H2O2 => 2-hydroxyoctadecanoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008043", "l": "MAPK8 phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352059", "l": "SLC6A15-mediated amino acid uptake (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36943", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2545196", "l": "FN1 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38617", "l": "ADP-D-ribose => cyclic ADP-beta-D-ribose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37773", "l": "1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21418", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37351", "l": "cytidine 2'-phosphate + H2O = cytidine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20782", "l": "ADP + GDP => ATP + GMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388808", "l": "CD28 homodimer binds B7-2 monomer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74547", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + talarodiene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43923", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203613", "l": "depalmitoylation of eNOS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64765", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043768", "l": "S-ribosylhomocysteine lyase activity", "d": ["Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46384", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47924", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (2S)-3-sulfolactaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.58", "l": "\"2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65943", "l": "(R)-glycerate + GDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24077", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641229", "l": "TLE oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5604929", "l": "Activated protein C binds Protein S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10761", "l": "citrate => acetate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37156", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901691", "l": "proton binding", "d": ["Binding to proton."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44425", "l": "a fatty acyl-CoA + heptadecasphing-4-enine => CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68856", "l": "(2Z,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002460", "l": "P4HB binds Collagen chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35948", "l": "dihydrochanoclavine-I aldehyde + NADP(+) => chanoclavine-I aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32913", "l": "sn-glycerol 3-phosphocholine(in) => sn-glycerol 3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34047", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.44", "l": "\"6'''-hydroxyneomycin C oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62645", "l": "(5Z,8Z)-eicosadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031014", "l": "troponin T binding", "d": ["Binding to troponin T, the tropomyosin-binding subunit of the troponin complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38184", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53271", "l": "L-ribulose <=> L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29468", "l": "H(+)(out) + K(+)(in) => H(+)(in) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43930", "l": "progesterone => pregn-5-ene-3,20-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112395", "l": "Abortive termination of elongation after arrest (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018808", "l": "RAC3 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193482", "l": "25(R) DHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57591", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35822", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) <=> 7,8-dihydromethanopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41745", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928641", "l": "PAK binds RAC and bPIX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44376", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211960", "l": "CYP2U1 19-hydroxylates ARA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164832", "l": "ATPase synthesizes ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15401", "l": "a dolichyl phosphate + UDP-alpha-D-glucose = a dolichyl beta-D-glucosyl phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.117", "l": "\"dolichyl-phosphate beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40506", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine <=> N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51621", "l": "CTP + formate + H(+) => CO2 + dCTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831514", "l": "CK2 phosphorylates nascent P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31047", "l": "(S)-2-methyl-3-oxopropanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.2", "l": "\"guanosine-3',5'-bis(diphosphate) 3'-diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39984", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20427", "l": "(S)-oxalosuccinate + ADP + H(+) + phosphate => 2-oxoglutarate + ATP + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57410", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421835", "l": "trans-Golgi Network Vesicle Scission (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627104", "l": "XIAP binds CASP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.134", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71843", "l": "tauroursodeoxycholate(out) = tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56616", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene = 1,2,4-trichlorobenzene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166753", "l": "Conversion of C4 into C4a and C4b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52294", "l": "13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58047", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose <=> 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28376", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982810", "l": "JAK2 phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10646", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73432", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647978", "l": "pro-RAS proteins are farnesylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11155", "l": "5-pyridoxate + NADPH + O2 <=> 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20218", "l": "H(+) + trimethylamine N-oxide => dimethylamine + formaldehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77534", "l": "hydrogen cyanide + nonanal <=> (2S)-2-hydroxydecanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76719", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19412", "l": "cholate + NAD(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54053", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + tau-cadinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76295", "l": "cob(I)alamin + S-adenosyl-L-methionine = methylcob(III)alamin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53528", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942302", "l": "MMP13 cleaves OPTC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647632", "l": "CASP3 cleaves GSDME (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63476", "l": "NADP(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668218", "l": "NBEA binds DLG3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16734", "l": "H(+) + orsellinate => CO2 + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877490", "l": "FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35448", "l": "(1'S)-averantin + NADP(+) => H(+) + NADPH + norsolorinic acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23583", "l": "prostaglandin H2 <=> prostaglandin I2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22680", "l": "dCTP + H(+) + H2O = dUTP + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.13", "l": "\"dCTP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031876", "l": "secretin receptor binding", "d": ["Binding to a secretin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23029", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] => acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31655", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008909", "l": "isochorismate synthase activity", "d": ["Catalysis of the reaction: chorismate = isochorismate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22921", "l": "L-glutamine + scyllo-inosose => 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73162", "l": "FMN(out) + NAD(+)(in) <=> FMN(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77257", "l": "beta-D-glucosylceramide(out) => beta-D-glucosylceramide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54046", "l": "7-epi-alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390116", "l": "Phospho FT reduces D accumulation at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46317", "l": "GDP-N,N'-diacetylbacillosamine + H2O => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034076", "l": "cucurbitadienol synthase activity", "d": ["Catalysis of the reaction: oxidosqualene = cucurbitadienol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53951", "l": "ATP + holo-[BtrI ACP] + L-glutamate <=> ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444476", "l": "FPRL2 receptor binds a wide range of ligands (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390929", "l": "HTR1 and 5A receptors can bind serotonin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392064", "l": "G alpha (z) inhibits adenylate cyclase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72551", "l": "glutarate(out) + urate(in) = glutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696670", "l": "CHD1L is recruited to GG-NER site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50103", "l": "dodecanoyl-CoA + taurine <=> CoA + H(+) + N-dodecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445704", "l": "Calcium Binds Caldesmon (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35984", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102971", "l": "phosphinothricin N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + phosphinothricin = H+ + coenzyme A(4-) + N-acetylphosphinatothricinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050147", "l": "nucleoside ribosyltransferase activity", "d": ["Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56637", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72309", "l": "L-glutamate(out) + taurocholate(in) => L-glutamate(in) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54855", "l": "H(+) + heptan-4-one + NADPH + O2 <=> H2O + NADP(+) + propyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10779", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40954", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O <=> acetate + L-2,4-diaminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858428", "l": "FCAMR binds IgA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140769", "l": "factor VII -> factor VIIa (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38322", "l": "chorismate + H2O <=> (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374662", "l": "Translocation of Ezrin to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75239", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549129", "l": "OCT1 transports organic cations into hepatic cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388596", "l": "Melanocortin receptors bind melanocortins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71190", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) <=> 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52070", "l": "(9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73985", "l": "(-)-beta-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10253", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine => L-cysteine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17728", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005385", "l": "zinc ion transmembrane transporter activity", "d": ["Enables the transfer of zinc (Zn) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32885", "l": "(+)-artemisinic aldehyde + H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696457", "l": "BDH2 dehydrogenates 3HBA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72419", "l": "(E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373342", "l": "CX3CR1 binds CX3CL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12638", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39391", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956568", "l": "RUNX1 binds the core TAL1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41146", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64812", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine = CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18767", "l": "a 1,2-diacyl-sn-glycerol + a sphingomyelin => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381727", "l": "RAP1A exchanges GDP for GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430183", "l": "NCK binds PAK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.17", "l": "\"deoxyribodipyrimidine endonucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17579", "l": "ADP-L-glycero-beta-D-manno-heptose => ADP-D-glycero-beta-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77334", "l": "glyoxylate + L-ornithine <=> 5-amino-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373074", "l": "Receptor CCR9  binds CCL25 ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.45013791078037", "identifiers": [{"i": "GO:0008375", "l": "acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168038", "l": "Collagen type XV restin release (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45313", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098641", "l": "cadherin binding involved in cell-cell adhesion", "d": ["Any cadherin binding that occurs as part of the process of cell-cell adhesion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9021357", "l": "PRKCI phosphorylates ELF3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64955", "l": "dCDP + H2O <=> dCMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50485", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57059", "l": "D-apiofuranose + NAD(+) <=> D-apionolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.58", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72635", "l": "eIF4F binds to mRNP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27338", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] => 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24442", "l": "ADP + H(+) + 2 phosphate(in) => ATP + H2O + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984733", "l": "Kinesin-3 is a dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0051540", "l": "metal cluster binding", "d": ["Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975633", "l": "atROL binds to RBP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23493", "l": "UDP-alpha-D-glucosamine => UDP-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351323", "l": "Release of 78 kDa glucose-regulated protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31377", "l": "1H-pyrrole + CO2 => H(+) + pyrrole-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65951", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 <=> A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36401", "l": "H(+) + NADPH + zymosterol => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6807872", "l": "Active ARF recruits coatomer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35152", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) => (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13134", "l": "CTP + di-trans,poly-cis-dolichol => a dolichyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.60", "l": "\"protein geranylgeranyltransferase type II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54541", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50424", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018850", "l": "chloromuconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664879", "l": "ATM:PEX5 binds ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417898", "l": "P2Y4 receptor can bind to UTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48546", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine => [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56417", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => alpha-D-glucose 1-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.605953599968913", "identifiers": [{"i": "GO:0015250", "l": "water channel activity", "d": ["Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47919", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine <=> ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20542", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 => 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68829", "l": "borneol + NAD(+) => camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16109", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.11", "l": "\"6-phosphofructokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63594", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433418", "l": "Phosphorylation of JAK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39876", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54949", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] => (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047580", "l": "4-hydroxyproline epimerase activity", "d": ["Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73334", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA <=> cimicifugate E + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53942", "l": "18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0019843", "l": "rRNA binding", "d": ["Binding to a ribosomal RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018638", "l": "toluene 4-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + H+ + NADH + O2 = 4-methylphenol + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26515", "l": "cyclohexan-1,2-dione + H2O => 6-oxohexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635842", "l": "ULK3 phosphorylates GLI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189488", "l": "UROS transforms HMB to URO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909755", "l": "Mitochondrial uptake of (R)-3-aminoisobutyric acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12825", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": [], "t": []}, {"i": "EC:1.21.4.3", "l": "\"sarcosine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691131", "l": "CANDI binds CUL1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0001016", "l": "RNA polymerase III transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15529", "l": "bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.60", "l": "\"bis(2-ethylhexyl)phthalate esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31171", "l": "(3S)-hydroxytetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.-", "l": "\"With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.6", "l": "\"DNA ligase (ATP or NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.171", "l": "\"rhamnogalacturonan hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030151", "l": "molybdenum ion binding", "d": ["Binding to a molybdenum ion (Mo)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25193", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430535", "l": "MASTL phosphorylates ENSA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71400", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18898", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32383", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12772", "l": "A + D-gluconate <=> 2-dehydro-D-gluconate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928656", "l": "gamma-secretase cleaves EPHB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202127", "l": "eNOS synthesizes NO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160931", "l": "Disassembly of tight junctions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29502", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61578", "l": "(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH => (4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44891", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68407", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) <=> 2-oxoheptanedioate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725117", "l": "ALK gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626816", "l": "PIN1 binds p-S345-NCF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420688", "l": "GABAB heterodimeric receptor binds GABA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44765", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18455", "l": "[(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate => [(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58533", "l": "15alpha-stemmadenine intermediate I + H2O => akuammicine + formate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36524", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43565", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine => [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73160", "l": "FMN(out) + NAD(+)(in) => FMN(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61310", "l": "germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51125", "l": "uridine in snRNA => pseudouridine in snRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681987", "l": "LC3 is cleaved by ATG4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23405", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026493", "l": "p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950782", "l": "p-STAT1 binds p-STAT3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043827", "l": "tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine57/adenosine58 in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N1-methyladenosine57/N1-methyladenosine58 in tRNA + 2 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12015", "l": "ATP + thiamine <=> ADP + H(+) + thiamine phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982645", "l": "GRKs bind ADRB2:Catecholamine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72621", "l": "Ribosomal scanning  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72679", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] = AMP + diphosphate + H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12445", "l": "hexadecanal + NADP(+) => (2E)-hexadecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29503", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + patchoulol", "d": [], "t": []}, {"i": "EC:4.2.3.70", "l": "\"patchoulol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10459", "l": "acetyl-CoA + D-maltose <=> 1-O-acetylmaltose + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17234", "l": "L-fucose => L-fuculose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373711", "l": "DCC interaction with Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015344", "l": "siderophore uptake transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62856", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141049", "l": "protein-glutathione oxidoreductase (glutathione) activity", "d": ["Catalysis of the reaction: glutathionylated protein (PSSG) + glutathione (GSH) = protein-thiol (PSH) + glutathione disulfide (GSSG). The reaction may proceed via a 'monothiol' or 'dithiol' mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13602", "l": "cis-4-hydroxy-L-proline + NAD(+) => 4-oxo-L-proline + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.5", "l": "\"thrombin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202137", "l": "AKT1 binds eNOS complex via HSP90 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22739", "l": "5-formimidoyltetrahydrofolate + 2 H(+) <=> (6R)-5,10-methenyltetrahydrofolate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018854", "l": "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610718", "l": "CK1 phosphorylates p-GLI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69469", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48341", "l": "a medium chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102974", "l": "hydroxyversicolorone reductase activity", "d": ["Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676599", "l": "sBAFF trimer binds BAFFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18833", "l": "4-formylbenzenesulfonate + H2O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.62", "l": "\"4-formylbenzenesulfonate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50061", "l": "ATP + glycochenodeoxycholate(in) + H2O => ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15270", "l": "L-xylo-hex-3-ulonolactone => H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28581", "l": "Co(2+)(in) <=> Co(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59448", "l": "dodecan-1-ol + NADP(+) = dodecanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72561", "l": "estrone 3-sulfate(in) + pentanoate(out) => estrone 3-sulfate(out) + pentanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58028", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH = a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.295", "l": "\"mycoketide-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14430", "l": "a [oligopeptide](in) + ATP + H2O => a [oligopeptide](out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987223", "l": "IL10RB binds TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193808", "l": "5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43110", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide => 2 Fe(III)-[cytochrome c] + H2O + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32112", "l": "S-adenosyl-L-methionine + trans-resveratrol => 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29828", "l": "Mg(2+)(in) => Mg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19030", "l": "3 H(+) + H2O + urea-1-carboxylate => 2 CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592240", "l": "Formation of NRF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399939", "l": "Autophosphorylation of PAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036239", "l": "taxoid 7beta-hydroxylase activity", "d": ["Catalysis of the reaction: taxusin + [reduced NADPH-hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O and 2alpha-hydroxytaxusin + [reduced NADPH-hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56678", "l": "(E)-feruloyl-CoA + H(+) + NADPH => dihydroferuloyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37497", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57405", "l": "NAD(+) + narcotine hemiacetal => H(+) + NADH + noscapine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693125", "l": "RHOF binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38237", "l": "1-O-octadecyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389381", "l": "Gads binds CD28 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73817", "l": "3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde => O2 + piceatannol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71303", "l": "RPE dimers isomerise RU5P to XY5P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16740", "l": "H(+) + NADH + O2 + toluene <=> (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731931", "l": "EDNRA binds selective ERAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52179", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140439", "l": "protein-cysteine S-stearoyltransferase activity", "d": ["Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59740", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12738", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine => [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24023", "l": "2-(N(omega)-L-arginino)succinate <=> fumarate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27897", "l": "3'-CMP + H2O <=> cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57504", "l": "3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64583", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + nerylneryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58816", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": [], "t": []}, {"i": "EC:6.3.2.53", "l": "\"UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102848", "l": "1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937814", "l": "RUNX3 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35740", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] => 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090542", "l": "ELYC domain binding", "d": ["Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41541", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52861", "l": "a short-chain fatty acid + ATP + CoA => a short-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11669", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426144", "l": "SREBP1A,2 binds the MVD promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140999", "l": "histone H3K4 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50176", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9702818", "l": "CALCR binds erenumab (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23375", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15432", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019781", "l": "NEDD8 activating enzyme activity", "d": ["Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade."], "t": []}, {"i": "EC:6.2.1.64", "l": "\"E1 NEDD8-activating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12705", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975633", "l": "atROL binds to RBP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67945", "l": "2-hydroxyhexadecanoate + O2 => 2-oxohexadecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56181", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12656", "l": "(S)-malate + NAD(+) <=> CO2 + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11227", "l": "ATP + 2 D-alanine <=> ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613207", "l": "EGR1 binds to the EGR1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179421", "l": "Degradation of multiubiquitinated Nek2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391934", "l": "DP2 receptor can bind PGD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52577", "l": "hexanoyl-CoA + NAD(+) => (2E)-hexenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035798", "l": "2-alkenal reductase (NADP+) activity", "d": ["Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54976", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O = (3S)-hydroxytetradecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.101", "l": "\"acylglycerone-phosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40468", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034789", "l": "2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429157", "l": "ABCC4 accumulation of dense granule contents (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66726", "l": "H2O + N-[(S)-lactoyl]-L-phenylalanine => (S)-lactate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686005", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848339", "l": "PNPLA5 hydrolyzes TAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166214", "l": "FA anion flip-flops to the opposite surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71218", "l": "2 Na(+)(out) + thiocyanate(out) <=> 2 Na(+)(in) + thiocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71090", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047771", "l": "carboxymethylhydantoinase activity", "d": ["Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047256", "l": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "d": ["Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000310", "l": "AURKA phosphorylates PLK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263490", "l": "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51872", "l": "dimethylallyl diphosphate + umbelliferone = diphosphate + osthenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32201", "l": "9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000277", "l": "[cytochrome c]-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389762", "l": "Phosphorylation of PD-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62807", "l": "2 7-demethylsiderin + NADPH + O2 <=> desertorin A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45784", "l": "2 H2O + phenylpropanonitrile = 3-phenylpropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227804", "l": "Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433418", "l": "Phosphorylation of JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46259", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209925", "l": "DIT and MIT combine to form triiodothyronine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017178", "l": "diphthine-ammonia ligase activity", "d": ["Catalysis of the reaction: ATP + diphthine + NH4 = ADP + diphthamide + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17008", "l": "ATP + D-glucuronate <=> 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39094", "l": "(2E)-decenedioyl-CoA + H2O <=> (3S)-hydroxydecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53119", "l": "an 11beta-hydroxysteroid + NAD(+) <=> an 11-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222128", "l": "NOC2L binds TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65137", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33285", "l": "6-oxohexanoate + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11285", "l": "hydroxymalonate + NAD(+) => H(+) + NADH + oxomalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42889", "l": "(R)-3-phosphomevalonate + ATP => (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18391", "l": "diphosphate + UDP-alpha-D-xylose => alpha-D-xylose 1-phosphate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23705", "l": "GTP + 4 H2O => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0070325", "l": "lipoprotein particle receptor binding", "d": ["Binding to a lipoprotein particle receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54335", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165043", "l": "Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44162", "l": "myo-inositol + phosphate => 1D-myo-inositol 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59699", "l": "D-cellotetraono-1,5-lactone + H2O <=> D-cellotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938913", "l": "RUNX1 binds ELF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655826", "l": "Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66768", "l": "ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047131", "l": "saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NAD+ = L-glutamate + allysine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17370", "l": "glycyrrhizin + H2O => 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31487", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose = H(+) + soyasaponin III + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.272", "l": "\"soyasapogenol B glucuronide galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77258", "l": "beta-D-glucosylceramide(in) <=> beta-D-glucosylceramide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75249", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein] => acetyl-CoA + N-terminal L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59621", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine => 4-aminobutanoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58603", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64216", "l": "2-carboxy-L-lyxonate + H(+) = CO2 + L-lyxonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678843", "l": "ISGylation of protein translation regulator 4EHP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23466", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806613", "l": "Keratin tetramers bind to form unit length filaments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20644", "l": "H2O + L-histidinol + 2 NAD(+) <=> 3 H(+) + L-histidine + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15129", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.99", "l": "\"(S)-limonene 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050135", "l": "NADP+ nucleosidase activity", "d": ["Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose-2-phosphate + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051117", "l": "ATPase binding", "d": ["Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64323", "l": "(9Z)-hexadecenoyl-CoA + cholesterol <=> cholesteryl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66845", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] => asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112430", "l": "Formation of P-TEFb complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74757", "l": "3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71769", "l": "2 Fe(3+) + NADPH => 2 Fe(2+) + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0042030", "l": "ATPase inhibitor activity", "d": ["Binds to and stops, prevents or reduces an ATP hydrolysis activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008974", "l": "phosphoribulokinase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39571", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16640", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41795", "l": "holo-[ACP] + malonyl-CoA <=> CoA + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71425", "l": "3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70482", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55947", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] <=> chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38407", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66641", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + koraiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18021", "l": "a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870465", "l": "RGGT binds the RAB-binding subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33823", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH = NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32114", "l": "S-adenosyl-L-methionine + trans-resveratrol <=> 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0000224", "l": "peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity", "d": ["Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111883", "l": "Hydrolysis of phosphatidylcholine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693540", "l": "MRN activates ATM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15758", "l": "L-homoserine + NAD(+) => H(+) + L-aspartate 4-semialdehyde + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77291", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675473", "l": "SH2B binds JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209910", "l": "Iodide is taken up by thyroid epithelial cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733247", "l": "YBX1 binds COL1A2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54964", "l": "hexadecanoyl-[ACP] + phosphate = hexadecanoyl phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209921", "l": "Monoiodinated tyrosine can be deiodinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56099", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) <=> [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818682", "l": "MEN1 binds MLL2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43035", "l": "3-chloro-D-alanine <=> 2-aminoprop-2-enoate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70398", "l": "3-oxosphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28028", "l": "[thioredoxin]-dithiol + UDP => [thioredoxin]-disulfide + dUDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69142", "l": "Recruitment of Dna2 endonuclease (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58167", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O <=> 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24204", "l": "acetyl phosphate + H(+) + sulfite = phosphate + sulfoacetaldehyde", "d": [], "t": []}, {"i": "EC:2.3.3.15", "l": "\"sulfoacetaldehyde acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62308", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-malbrancheamide B + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804229", "l": "JMY, TTC5 and EP300 bind (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70050", "l": "2-oxoadipate + L-kynurenine <=> H2O + kynurenate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55817", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690896", "l": "SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917730", "l": "Cargo Recognition And Sorting (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879942", "l": "The receptor is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034549", "l": "N-cyclopropylammelide alkylamino hydrolase activity", "d": ["Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46276", "l": "(S)-malate + H(+) = (S)-lactate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.101", "l": "\"malolactic enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795460", "l": "SGK1 phosphorylates MDM2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59674", "l": "D-maltotriono-1,5-lactone + H2O2 => D-maltotriose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697920", "l": "CLOCK acetylates lysine-10 of histone H3, H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15829", "l": "a 16alpha-hydroxysteroid = a 16beta-hydroxysteroid", "d": [], "t": []}, {"i": "EC:5.1.99.2", "l": "\"16-hydroxysteroid epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029471", "l": "Hydrolysis of PC to PA by PLD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51829", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31755", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": [], "t": []}, {"i": "EC:3.3.2.12", "l": "\"oxepin-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22144", "l": "cis-aconitate + H2O = D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663273", "l": "RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64900", "l": "H2O + UTP = H(+) + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20395", "l": "(R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP] => holo-[citrate lyase ACP] + S-acetylphosphopantotheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48201", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA => reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433395", "l": "Dimerization of sSCF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40662", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43914", "l": "(25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159771", "l": "Furin cleaves pro-protein C to protein C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25831", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 <=> A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32930", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603467", "l": "Activated protein C is released from PROCR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19358", "l": "H(+) + L-proline betaine + NADPH + O2 => formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25970", "l": "benzil + H(+) + NADPH => (S)-benzoin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018637", "l": "1-hydroxy-2-naphthoate hydroxylase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NAD(P)H + 2 H+ = NAD(P)+ + H2O + CO2 + 1,2-dihydroxynaphthalene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980125", "l": "ITCH binds DTX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631941", "l": "SESN1,2,3 bind AMPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35725", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + CoA => hexadecanoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55731", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047564", "l": "3-hydroxycyclohexanone dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675026", "l": "Formation of the MLL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13774", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58319", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69525", "l": "D-sorbitol + O2 => D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26551", "l": "(S)-piperazine-2-carboxamide + H2O => (S)-piperazine-2-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334794", "l": "FABPs bind LCFAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592249", "l": "NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006873", "l": "IL21 receptor STAT binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54911", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (4E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031855", "l": "oxytocin receptor binding", "d": ["Binding to an oxytocin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20410", "l": "alpha-D-glucose 1-phosphate + riboflavin => D-glucose + FMN", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696268", "l": "RND3 binds effectors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27751", "l": "2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863471", "l": "LDLR is bound by DAB2 and ARH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928624", "l": "EPHBs bind EFNBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33284", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 => 6-oxohexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032781", "l": "WWTR1 (TAZ) binds TEAD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58642", "l": "a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70780", "l": "D-glucose + NADP(+) => 6-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015658", "l": "branched-chain amino acid transmembrane transporter activity", "d": ["Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings."], "t": []}, {"i": "REACT:R-HSA-9672770", "l": "SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46749", "l": "carboxyphosphate + NH4(+) => carbamate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201708", "l": "Frizzled receptors bind Wnts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46589", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49937", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36826", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol <=> CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180732", "l": "Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38034", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24831", "l": "ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62133", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP => a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42516", "l": "H2O + L-gulono-1,4-lactone = H(+) + L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34484", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32732", "l": "a diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11387", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928615", "l": "EFNBs bind SFKs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52729", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate => a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13817", "l": "[protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone + [protein]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70089", "l": "hydroxyclavatol methyl ether => methanol + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16478", "l": "NAD(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75467", "l": "ethanolamine(out) + n H(+)(in) = ethanolamine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380294", "l": "Loss of C-Nap-1 from centrosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204824", "l": "Interaction of Tie2 and Ang4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30592", "l": "H2O + O2 + tyramine => (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61696", "l": "ATP + glycine + holo-[peptidyl-carrier protein] = AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.66", "l": "\"glyine--[glycyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809707", "l": "MTMR12 binds MTMR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77077", "l": "Capping complex formation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051407", "l": "glycerone phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32238", "l": "(6S)-NADPHX + ADP <=> AMP + H(+) + NADPH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29656", "l": "L-cysteine(in) => L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112271", "l": "The receptor:G-protein complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140842", "l": "n fibrin monomers -> fibrin multimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159771", "l": "Furin cleaves pro-protein C to protein C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689111", "l": "PARK2 autoubiquitinates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0016917", "l": "GABA receptor activity", "d": ["Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22574", "l": "AH2 + formaldehyde + L-glutamate => A + H2O + N-methyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11119", "l": "acetyl-CoA + an alkane-alpha,omega-diamine <=> an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41669", "l": "dihydrochelirubine + NADP(+) => chelirubine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018594", "l": "MECP2 binds LBR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981353", "l": "RASA1 stimulates RAS GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17581", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O = an L-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.87", "l": "\"N-carbamoyl-L-amino-acid hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24925", "l": "2-oxobutanoate + NH4(+) => L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31660", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45813", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA => a very-long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34653", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.54", "l": "\"gamma-renin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418553", "l": "cAMP degradation by Phosphodiesterases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56913", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) => (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62558", "l": "4-methylcatechol + CO2 => 3,4-dihydroxyphenylacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111237", "l": "Formation of ADAR1 homodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021068", "l": "PalmS-ESRs bind CAVs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443779", "l": "Linkage of L1 with treadmilling F-actin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432897", "l": "ILK interacts with beta-1 integrin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033871", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022819", "l": "potassium ion uniporter activity", "d": ["Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877187", "l": "P2X7 mediates loss of intracellular K+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62359", "l": "8-oxo-GDP + H2O <=> 8-oxo-GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41274", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016649", "l": "oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound."], "t": []}, {"i": "EC:1.5.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218805", "l": "PKC autophosphorylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43731", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25280", "l": "3',5'-cyclic AMP + H2O <=> AMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389352", "l": "Translocation of Vav1 to CD28 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202966", "l": "Caspase mediated cleavage of HIP-55 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903875", "l": "corticosterone binding", "d": ["Binding to corticosterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32884", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) => (+)-artemisinic aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015391", "l": "nucleobase:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20165", "l": "H2O + N(5)-acyl-L-ornithine ester = an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": [], "t": []}, {"i": "EC:3.1.1.48", "l": "\"fusarinine-C ornithinesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14843", "l": "ent-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034811", "l": "benzo(a)pyrene 9,10-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399913", "l": "atRAL binds to RBP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31134", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49780", "l": "docosanoyl-CoA + glycine = CoA + H(+) + N-docosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31707", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34707", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": [], "t": []}, {"i": "EC:4.7.1.1", "l": "\"alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50583", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67736", "l": "N-acetyl-alpha-neuraminate = aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75677", "l": "(12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202714", "l": "CD58 binds CD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17850", "l": "(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047109", "l": "(S)-3-hydroxyacid-ester dehydrogenase activity", "d": ["Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43672", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016361", "l": "activin receptor activity, type I", "d": ["Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17590", "l": "2,2'-iminodipropanoate + H2O + NAD(+) => H(+) + L-alanine + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36886", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43031", "l": "L-cysteate <=> 2-aminoprop-2-enoate + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75976", "l": "(S)-stylopine + S-adenosyl-L-methionine => (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56488", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68389", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 => 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950778", "l": "p-Y693-STAT4 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10784", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821368", "l": "AKAP8L binds MLL1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18065", "l": "ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)", "d": [], "t": []}, {"i": "EC:7.3.2.2", "l": "\"ABC-type phosphonate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55353", "l": "all-trans-retinol => 13-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10208", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": [], "t": []}, {"i": "EC:2.3.2.8", "l": "\"arginyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604722", "l": "Activation of proMMP9 by proteases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036192", "l": "3-hydroxyindolin-2-one monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72992", "l": "2 Na(+)(out) + scyllo-inositol(out) => 2 Na(+)(in) + scyllo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678327", "l": "MIOX oxidises Ins to GlcA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391941", "l": "BLT receptors can bind LTB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5632677", "l": "PTCH is internalized (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32653", "l": "erythromycin B + H(+) + S-adenosyl-L-homocysteine => erythromycin D + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11261", "l": "H(+) + NADPH + O2 => H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61277", "l": "H2O + L-ornithine + O2 => 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24458", "l": "alpha-ribazole + phosphate => alpha-ribazole 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71172", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) => H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790454", "l": "SUMOylation of XPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951486", "l": "CD46 binds C4b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19488", "l": "sphing-4-enine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981353", "l": "RASA1 stimulates RAS GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17284", "l": "(2S)-4-acetamido-2-aminobutanoate <=> H2O + L-ectoine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39975", "l": "2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67691", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O <=> 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47834", "l": "a ganglioside GM1 + N-acetylneuraminate => a ganglioside GD1a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20843", "l": "H(+) + L-histidine <=> CO2 + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62734", "l": "(+)-isomalbrancheamide D + FADH2 => (+)-isomalbrancheamide B + bromide + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432426", "l": "CRY is activated by light and binds to cytosolic TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33821", "l": "3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52590", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => choloyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27535", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3R,6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55998", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57572", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34702", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-isocomene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71337", "l": "chloride(in) + L-tryptophan(in) + 2 Na(+)(in) => chloride(out) + L-tryptophan(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68436", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 = (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140262", "l": "mRNA cap binding complex binding", "d": ["Binding to a mRNA cap binding complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61594", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine => H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24150", "l": "(2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36133", "l": "methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine => (indol-3-yl)acetate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004765", "l": "shikimate kinase activity", "d": ["Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69967", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64056", "l": "(1S,2R)-ephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32267", "l": "4-aminobutanoate + glyoxylate = glycine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650858", "l": "Meglitinides bind ABCC8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218822", "l": "CRK binds BCAR1 and or PXN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904769", "l": "isopentadecanoic acid binding", "d": ["Binding to isopentadecanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73585", "l": "CTP(in) + UDP(out) => CTP(out) + UDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75898", "l": "holothin + marinoloyl-CoA C <=> CoA + thiomarinol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43175", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15339", "l": "CoA + H(+) + phenylglyoxylate => H2O + phenylglyoxylyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099108", "l": "potassium channel activator activity involved in G protein-coupled receptor signaling pathway", "d": ["Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53329", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine => 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203977", "l": "SAR1 Activation And Membrane Binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33194", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70655", "l": "L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850945", "l": "Casein kinase II phosphorylates PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159253", "l": "MMAB adenosylates cob(I)alamin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13969", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}, {"i": "EC:6.5.1.5", "l": "\"RNA 3'-terminal-phosphate cyclase (GTP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863013", "l": "CDK5 binds p25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14910", "l": "L-gulonate + NADP(+) => aldehydo-D-glucuronate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66975", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54629", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 => 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197564", "l": "NOTCH2 stimulates transcription of HES5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007514", "l": "E2F1 binds APAF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71197", "l": "H(+)(in) + Zn(2+)(in) => H(+)(out) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390470", "l": "Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032115", "l": "sorbose reductase activity", "d": ["Catalysis of the reaction: D-glucitol + NADP+ = L-sorbose + H+ + NADPH. The reaction may occur, to a minor extent, in the reverse direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28217", "l": "[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134954", "l": "DHX9 binds DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65109", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] => aculene A + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55620", "l": "a carotenoid psi-end group = a carotenoid beta-end derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983680", "l": "OAS1 produces oligoadenylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669023", "l": "TWEAK binds FN14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59317", "l": "D-cellobiose + O2 => D-cellobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24478", "l": "H(+) + maleamate => H2O + maleimide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609921", "l": "SGTA binds Tail-anchored protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63152", "l": "an N-fatty acyl-taurine + H2O = a fatty acid + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941895", "l": "Formation of CDK4/6:CCND complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21609", "l": "isoliquiritigenin + S-adenosyl-L-methionine => 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250930", "l": "B-WICH recruits histone acetyltransferases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071551", "l": "RIP homotypic interaction motif binding", "d": ["Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852317", "l": "PLK1 phosphorylates GTSE1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446322", "l": "PARVA associates with Paxillin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23040", "l": "2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.6", "l": "\"2-ethylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804879", "l": "MDM2 ubiquitinates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061664", "l": "Pup ligase activity", "d": ["Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S = X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865626", "l": "p-STAT5 dimers bind the BRWD1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43819", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34925", "l": "nitrate(out) => nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12131", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12339", "l": "carboxymethoxysuccinate <=> fumarate + glycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45365", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine => (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49850", "l": "(-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (-)-dehydrodiconiferyl acid ketone + a quinone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102988", "l": "9,12-cis-hexadecadienoic acid delta 15 desaturase activity", "d": ["Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor = 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873927", "l": "Release of STAT1 dimer from active receptor unit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52464", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48559", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047148", "l": "methylamine-glutamate N-methyltransferase activity", "d": ["Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997237", "l": "SH2B proteins bind JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12214", "l": "9H-fluoren-9-one + H(+) + NADPH => 9H-fluoren-9-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62586", "l": "ADP + H(+) + L-tyrosine(in) + phosphate => ATP + H2O + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75478", "l": "D-mannose(out) + n Na(+)(out) <=> D-mannose(in) + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15807", "l": "(4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate => (7R,8S)-7,8-diammoniononanoate + ATP + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50227", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42843", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46059", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40789", "l": "CoA + H(+) + tetracosanoate => H2O + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67841", "l": "a lipid A disaccharide + ATP => a lipid IVA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55854", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102254", "l": "neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarotetraose + H2O = 3,6-anhydro-alpha-L-galactopyranose + agarotriose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70788", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) => H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45282", "l": "12-hydroxyoctadecanoate + phosphate => 12-(phosphooxy)octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004100", "l": "chitin synthase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52097", "l": "9-octadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005527", "l": "macrolide binding", "d": ["Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5674385", "l": "p-T,Y MAPKs dimerize (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034820", "l": "4,9-DSHA hydrolase activity", "d": ["Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004131", "l": "cytosine deaminase activity", "d": ["Catalysis of the reaction: cytosine + H2O = uracil + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10100", "l": "a sterol ester + H2O = a fatty acid + a sterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68289", "l": "heptanoyl-CoA + L-seryl-[protein] => CoA + O-heptanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928631", "l": "GIT1 binds bPIX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50065", "l": "ATP + H2O + taurochenodeoxycholate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41688", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12891", "l": "3-dehydro-L-gulonate + H(+) + NADH => L-gulonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592250", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65343", "l": "acetyl-CoA + L-threonyl-[protein] <=> CoA + O-acetyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047705", "l": "bilirubin oxidase activity", "d": ["Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545253", "l": "Deacetylation of cohesin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13495", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH => (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13888", "l": "H2O + stipitatonate <=> CO2 + stipitatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30683", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP", "d": [], "t": []}, {"i": "EC:3.2.1.183", "l": "\"UDP-N-acetylglucosamine 2-epimerase (hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77566", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol <=> 1-(9Z-octadecenoyl)-3-hexadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875591", "l": "DOCK7 activates RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47386", "l": "acetate + H(+) + hydroquinone => 4-acetoxyphenol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77523", "l": "butanal + hydrogen cyanide = (2S)-2-hydroxypentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68489", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) => CO2 + H2O + tridecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33672", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77125", "l": "1D-myo-inositol 1,2,3-trisphosphate + phosphate => 1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25080", "l": "4-methyl-2-oxopentanoate + CO2 => (2S)-2-isopropyl-3-oxosuccinate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850818", "l": "SPINK9 binds KLK5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73922", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) <=> H2O + norlichexanthone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870461", "l": "RABGGTA and RABGGTB bind (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990763", "l": "arrestin family protein binding", "d": ["Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74218", "l": "H2O + L-seryl-tRNA(Lys) <=> L-serine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183067", "l": "Localization of CBL:GRB2 to the membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696146", "l": "AOC2 deaminates TYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14316", "l": "2-iodophenol + S-adenosyl-L-methionine <=> 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50048", "l": "ATP + cholate(in) + H2O = ADP + cholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177922", "l": "EGFR dimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66962", "l": "beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12734", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73025", "l": "pregnenolone sulfate(in) => pregnenolone sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004140", "l": "dephospho-CoA kinase activity", "d": ["Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30530", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> ADP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2529020", "l": "CK2 phosphorylates condensin I subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62751", "l": "H2O + lovastatin <=> (S)-2-methylbutanoate + H(+) + monacolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59484", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O = arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}, {"i": "EC:1.20.2.1", "l": "\"arsenate reductase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684140", "l": "ATM phosphorylates RBBP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944265", "l": "Association of procollagen type IV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52066", "l": "(9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74063", "l": "2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68578", "l": "ADP + H(+) + phosphate + xanthine(in) => ATP + H2O + xanthine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77209", "l": "3alpha-sulfoglycodeoxycholate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + glycodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062153", "l": "C5-methylcytidine-containing RNA reader activity", "d": ["A protein adaptor that recognizes and binds an RNA molecule modified by C5-methylcytidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77374", "l": "[alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate <=> [alpha-N-acetylneuraminyl-(2->8)](n+1)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72250", "l": "(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46212", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine = 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74274", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP <=> a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033728", "l": "divinyl chlorophyllide a 8-vinyl-reductase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62722", "l": "betaenone B + 3 H2O + 3 NADP(+) => 3 H(+) + 3 NADPH + 3 O2 + probetaenone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73965", "l": "aristolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048032", "l": "galacturonate binding", "d": ["Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701147", "l": "TRPV1 binds TRPV1 blockers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34561", "l": "1-deoxy-11-oxopentalenate + H(+) + NADH => 1-deoxy-11beta-hydroxypentalenate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015048", "l": "phthalate dioxygenase reductase activity", "d": ["Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66519", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20331", "l": "ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor] => ATP + L-seryl-[low-density-lipoprotein receptor]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322431", "l": "XIAP binds TLE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40992", "l": "(E)-4-coumaroyl-CoA + H2O => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874080", "l": "SRC phosphorylates PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70511", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44088", "l": "ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028820", "l": "Formation of VAF (virus-activated factor) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706319", "l": "Active FLT3 binds to SLA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24334", "l": "H2O + monacolin L carboxylate => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446322", "l": "PARVA associates with Paxillin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156930", "l": "GTP-binding activates eEF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632738", "l": "DDIT4 binds 14-3-3 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35242", "l": "tetracycline(in) <=> tetracycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.7", "l": "\"tetrahydrocannabinolic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71580", "l": "CDP(out) + CDP-L-ribitol(in) => CDP(in) + CDP-L-ribitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58876", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30806", "l": "4-aminobutanal + H2O + NADP(+) <=> 4-aminobutanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141367", "l": "Myristoylation of tBID by NMT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005295", "l": "neutral L-amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64789", "l": "(E)-cinnamate + ATP + CoA => (E)-cinnamoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23272", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose = an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.118", "l": "\"cytokinin 7-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888589", "l": "Release of GABA at the synapse (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76581", "l": "(6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NADP(+) => (2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396234", "l": "Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38109", "l": "L-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690449", "l": "S1PR1 bind S1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51617", "l": "ATP + formate + H(+) => CO2 + dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203774", "l": "Interaction of Csk with PAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11546", "l": "H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29589", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH => 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68350", "l": "diphosphate + pppA(2'-5')pG => ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50070", "l": "ADP + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glycoursodeoxycholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23183", "l": "a secondary alcohol + O2 <=> a ketone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168888", "l": "Alpha1-Microglobulin binds heme (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42381", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O => 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21791", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46405", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16142", "l": "2'-deoxymugineate + NAD(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976768", "l": "Factor H binds to C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0042171", "l": "lysophosphatidic acid acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72541", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH => 3,4-dihydroxybenzaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11747", "l": "H2O + thiamine triphosphate <=> H(+) + phosphate + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32209", "l": "(3Z)-2-oxohex-3-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852019", "l": "MET bound PI3K generates PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56459", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-fischerindole U", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52542", "l": "alpha-D-ribose 1-phosphate + cytosine => cytidine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.53", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47539", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isochenodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140930", "l": "fructose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-fructose(out) + Na+(out) = D-fructose(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848864", "l": "PTK6 binds ARAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665727", "l": "FMNL2 binds CDC42:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11169", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) => 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428917", "l": "G13 activation by TP receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318590", "l": "Defective MMACHC does not decyanate CNCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989750", "l": "Expression of FATP1 (SLC27A1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684261", "l": "MAP3K8 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615910", "l": "SUMOylation of PCNA with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57478", "l": "2-hydroxydodecanoate + H2O => dodecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14021", "l": "AH2 + ecdysone + O2 = 20-hydroxyecdysone + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.22", "l": "\"ecdysone 20-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77541", "l": "1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43630", "l": "aminoacetaldehyde + CO2 + NADH => L-serine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678920", "l": "TLR processing at low pH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928597", "l": "EPH:EFN dimers tetramerise (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71684", "l": "2 H(+)(out) + L-aspartyl-glycine(out) => 2 H(+)(in) + L-aspartyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.9", "l": "\"dTMP kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.-", "l": "\"Metallocarboxypeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75669", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => (11Z,14Z,17Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664278", "l": "Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37933", "l": "(10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3878123", "l": "Initiation of SAHF formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031833", "l": "type 7 serotonin receptor binding", "d": ["Binding to a type 7 serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015514", "l": "nitrite efflux transmembrane transporter activity", "d": ["Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830368", "l": "Expression of EMX2 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013488", "l": "HEYL gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865275", "l": "PDGF-BB clevage by Furin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33182", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45508", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35355", "l": "3-hydroxyisopentadecanoyl-CoA = (2E)-13-methyltetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102463", "l": "quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose = quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35527", "l": "H(+) + N-ethylmaleimide + NADH = N-ethylsuccinimide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875817", "l": "MET phosphorylates STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52072", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75347", "l": "thiocyanate(in) = thiocyanate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48021", "l": "a globoside Gb3Cer + H2O => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69881", "l": "castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50453", "l": "prostaglandin H3 => prostaglandin E3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61488", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15718", "l": "daunorubicin + H(+) + NADPH + O2 => doxorubicin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102699", "l": "2-methylpropionitrile hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH = 2-hydroxy-2-methylpropanenitrile + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043999", "l": "histone H2AK5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34718", "l": "15-methylhexadecasphing-4-enine + ATP <=> 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.23", "l": "\"PepB aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21857", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187506", "l": "Translocation of p27 to the nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052933", "l": "alcohol dehydrogenase (cytochrome c(L)) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854466", "l": "VLDLR binds RELN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27365", "l": "bromide + S-adenosyl-L-methionine = bromomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0008066", "l": "glutamate receptor activity", "d": ["Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57748", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53426", "l": "an N-acyl-sphingoid base + CoA + H(+) => a fatty acyl-CoA + a sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939129", "l": "miR-215 binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17655", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1901235", "l": "(R)-carnitine transmembrane transporter activity", "d": ["Enables the transfer of (R)-carnitine from one side of a membrane to the other."], "t": []}, {"i": "RHEA:34959", "l": "(R)-carnitine(in) = (R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561072", "l": "OCT3 mediates renal uptake of organic cations (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103003", "l": "oleate peroxygenase activity", "d": ["Catalysis of the reaction: oleate + a lipid hydroperoxide = 9,10-epoxystearate + a lipid alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12096", "l": "H2O + N-benzylformamide = benzylamine + formate", "d": [], "t": []}, {"i": "EC:3.5.1.91", "l": "\"N-substituted formamide deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54177", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) => a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800797", "l": "The PIDDosome activates CASP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052728", "l": "capsorubin synthase activity", "d": ["Catalysis of the reaction: violaxanthin = capsorubin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0000104", "l": "succinate dehydrogenase activity", "d": ["Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62625", "l": "[glutaredoxin]-dithiol + a hydroperoxide => [glutaredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14002", "l": "choloyl-CoA + glycine => CoA + glycocholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.84", "l": "\"alcohol-forming fatty acyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432129", "l": "FGR binds and phosphorylates LRP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517705", "l": "p-S318,221-HuR binds mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76521", "l": "(R)-lipoate + L-lysyl-[lipoyl-carrier protein] => H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45847", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) <=> 3-oxooctanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.14", "l": "\"bile-salt sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004996", "l": "thyroid-stimulating hormone receptor activity", "d": ["Combining with thyroid-stimulating hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16158", "l": "2 Fe(III)-[leghemoglobin] + NADPH => 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852324", "l": "GTSE1 binds PLK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70034", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796051", "l": "AcK-NFE2L2 binds the AREG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004060", "l": "arylamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69004", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite = AMP + cremeomycin + diphosphate + H2O", "d": [], "t": []}, {"i": "EC:6.7.1.1", "l": "\"3-amino-2-hydroxy-4-methoxybenzoate diazotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828722", "l": "SH mRNA is translated into protein SH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49976", "l": "butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61274", "l": "2-oxopentanoate + H2O2 + NH4(+) => H2O + L-2-aminopentanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043906", "l": "Ala-tRNA(Pro) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44411", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52080", "l": "12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24112", "l": "2 glutathione + O2 = glutathione disulfide + H2O2", "d": [], "t": []}, {"i": "EC:1.8.3.3", "l": "\"glutathione oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52113", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16511", "l": "CO2 + formate => H(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34908", "l": "molybdate(in) => molybdate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65291", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20687", "l": "H(+) + keto-D-tagatose + NADH => galactitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507868", "l": "Aquaporins passively transport water into cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64979", "l": "8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52517", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36731", "l": "1-nitrocyclohexan + NADP(+) = 1-nitrocyclohexene + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428609", "l": "Type I Na+-coupled phosphate co-transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.40", "l": "\"(R)-2-hydroxyglutarate--pyruvate transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9833973", "l": "ISGylation of PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62087", "l": "ADP + D-glucosamine <=> AMP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669893", "l": "KIT binds type I TKIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11054", "l": "4-aminophenol + CO2 + H2O + NAD(+) => 4-aminobenzoate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43891", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine <=> [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77223", "l": "gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine = 5'-deoxyadenosine + cob(III)alamin + geneticin + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38278", "l": "(3R)-citramalyl-CoA <=> acetyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0008875", "l": "gluconate dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69029", "l": "5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692764", "l": "MAPK6 binds CCND3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45096", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964280", "l": "Active Gq binds BTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74184", "l": "S-adenosyl-L-methionine + taxifolin => H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42960", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] = NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71859", "l": "glycochenodeoxycholate(out) = glycochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50226", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67706", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72975", "l": "2 ATP + 2 indole-3-pyruvate = 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63916", "l": "5-fluorouridine + ATP = 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015606", "l": "spermidine transmembrane transporter activity", "d": ["Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other."], "t": []}, {"i": "RHEA:35039", "l": "spermidine(in) = spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45546", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10521", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53771", "l": "allocholate + allodeoxycholoyl-CoA <=> allocholoyl-CoA + allodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016936", "l": "galactoside binding", "d": ["Binding to a glycoside in which the sugar group is galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28033", "l": "[thioredoxin]-disulfide + dGDP + H2O <=> [thioredoxin]-dithiol + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60214", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432521", "l": "Nuclear TIM is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189488", "l": "UROS transforms HMB to URO3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66051", "l": "2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39347", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76031", "l": "2 H2O2 => O2 + 2 H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23953", "l": "H2O + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015254", "l": "glycerol channel activity", "d": ["Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.22", "l": "\"metallocarboxypeptidase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26235", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol => (2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570528", "l": "SUMOylation of XPC with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18331", "l": "(1S,5S)-sabinone + H(+) + NADH => (1S,3R,5S)-sabinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14682", "l": "2 2-aminophenol + A + O2 => 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678920", "l": "TLR processing at low pH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170674", "l": "Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.29", "l": "\"Kdo2-lipid A phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30912", "l": "a sphingomyelin + H2O => a carboxylate + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726580", "l": "PGR binds PGR agonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16886", "l": "2 bilirubin-glucuronoside => bilirubin IXalpha + bilirubin-bisglucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69969", "l": "Ca(2+)(in) + K(+)(in) + 4 Na(+)(out) => Ca(2+)(out) + K(+)(out) + 4 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201629", "l": "Caspase-mediated cleavage of Tau (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032021", "l": "RvT1-4 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004595", "l": "pantetheine-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46532", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.16", "l": "\"linoleoyl-lipid Delta(12) conjugase (11E,13Z-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13244", "l": "ATP + L-fucose <=> ADP + beta-L-fucose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13341", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40513", "l": "(2S)-3-sulfolactaldehyde + H(+) + NADH => (2S)-3-sulfopropanediol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38274", "l": "(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66020", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649856", "l": "Oxidative damage to the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033905", "l": "xylan endo-1,3-beta-xylosidase activity", "d": ["Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28259", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate => cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17259", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine => O2 + reduced [NADPH--hemoprotein reductase] + vinorine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57530", "l": "a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050452", "l": "CoA-glutathione reductase (NADP) activity", "d": ["Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132277", "l": "Complement factor H binds to surface-bound C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389862", "l": "Conversion of glyoxylate to oxalate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996727", "l": "REST recruits the BHC complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46209", "l": "ATP + CoA + eicosanoate => AMP + diphosphate + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60341", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391942", "l": "IP receptor can bind prostacyclin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31754", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63886", "l": "H2O + L-dopa => H2O2 + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37105", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19190", "l": "H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate => CO2 + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77526", "l": "butanal + hydrogen cyanide <=> (2S)-2-hydroxypentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936380", "l": "Interaction of PIN1 with p-IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65254", "l": "diphosphate + verruculide C => (2E,6E)-farnesyl diphosphate + 6-hydroxymellein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28276", "l": "(R)-S-adenosyl-L-methionine => (S)-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49290", "l": "AMP + diphosphate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] => (R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55587", "l": "an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50519", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990528", "l": "Interaction of PCBP2 with MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2423785", "l": "CR:atREs binds apoE and HSPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388503", "l": "Oxytocin receptor bind oxytocin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876484", "l": "NPC2 transfers CHOL to NPC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51259", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 <=> (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31857", "l": "achilleol B => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51260", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22235", "l": "H(+) + NADPH + presqualene diphosphate <=> diphosphate + NADP(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022893", "l": "low-affinity tryptophan transmembrane transporter activity", "d": ["Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63776", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804955", "l": "ATM phosphorylates MDM2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18829", "l": "4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.290", "l": "\"4-phosphoerythronate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42575", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) <=> 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50904", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54547", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine <=> 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20470", "l": "H2O + IMP => D-ribose 5-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.78", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44065", "l": "hexadecanoyl-CoA + octan-1-ol => CoA + octyl hexadecanoyl", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52942", "l": "chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => chenodeoxycholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30274", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 <=> 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15988", "l": "formate + NAD(+) <=> CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60360", "l": "FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2", "d": [], "t": []}, {"i": "EC:1.3.8.17", "l": "\"dehydro coenzyme F420 reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77537", "l": "H(+) + L-methionine + tRNA(Leu) => H2O + L-methionyl-tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798372", "l": "ATM phosphorylates DYRK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013435", "l": "RHOD auto-activates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33755", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114284", "l": "Release of Cytochrome c from mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48755", "l": "2-oxoglutarate + O2 + validamycin A <=> CO2 + H(+) + succinate + validamycin B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008449", "l": "N-acetylglucosamine-6-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14191", "l": "N-formyl-D-kynurenine => D-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016603", "l": "glutaminyl-peptide cyclotransferase activity", "d": ["Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042937", "l": "tripeptide transmembrane transporter activity", "d": ["Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.19", "l": "\"carboxypeptidase Taq\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690152", "l": "USP5 cleaves polyubiquitin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13479", "l": "H(+) + indole-3-pyruvate + NADPH + NH4(+) => H2O + L-tryptophan + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42733", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30382", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665998", "l": "MKL1 binds SRF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29892", "l": "ATP + H2O + L-histidine(out) => ADP + H(+) + L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51508", "l": "2-oxoglutarate + L-proline + O2 = CO2 + succinate + trans-4-hydroxy-L-proline", "d": [], "t": []}, {"i": "EC:1.14.11.57", "l": "\"L-proline trans-4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20652", "l": "23,24-dihydrocucurbitacin B + NADP(+) <=> cucurbitacin B + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674531", "l": "AAMP binds EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830480", "l": "Expression of RET in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13303", "l": "a 1-acyl-sn-glycerol + a sterol ester => a 1,2-diacyl-sn-glycerol + a sterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674093", "l": "PDGFRs bind type I TKI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928619", "l": "PAK1 binds RAC1:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19751", "l": "[(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42062", "l": "11-cis-retinal + H(+) + NADH => 11-cis-retinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58946", "l": "7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55194", "l": "2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methyldodecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204311", "l": "AOX1 oxidises PXL to PDXate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015454", "l": "light-driven active monoatomic ion transmembrane transporter activity", "d": ["Active transport of an ion across a membrane, driven by light."], "t": []}, {"i": "TCDB:3.E", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30287", "l": "15-cis-phytoene + 2 a plastoquinone = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399995", "l": "Muscarinic Acetylcholine Receptor M3 activates Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46214", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + formate => H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68830", "l": "camphor + H(+) + NADH => borneol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21355", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75510", "l": "n H(+)(out) + taurocholate(out) <=> n H(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857555", "l": "EGFR phosphorylates GPNMB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005546", "l": "phosphatidylinositol-4,5-bisphosphate binding", "d": ["Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71876", "l": "2 Na(+)(out) + taurocholate(out) => 2 Na(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34652", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176445", "l": "SMURF2 binds SMAD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694421", "l": "PP6 dephosphorylates SEC24 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016519", "l": "gastric inhibitory peptide receptor activity", "d": ["Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68623", "l": "cortisone + H(+) + NADPH <=> 20beta-dihydrocortisone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.923108426128749", "identifiers": [{"i": "GO:0004619", "l": "phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625883", "l": "PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398185", "l": "LARG binds plexin B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0070547", "l": "L-tyrosine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56844", "l": "nocamycin E + S-adenosyl-L-methionine = nocamycin I + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.351", "l": "\"nocamycin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731141", "l": "Syndecan-1 binds fibronectin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19031", "l": "2 CO2 + 2 NH4(+) => 3 H(+) + H2O + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51606", "l": "4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018794", "l": "2-hydroxyisobutyrate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61620", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose = [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.374", "l": "\"beta-1,2-mannooligosaccharide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35744", "l": "H(+) + NADPH + O2 + versicolorin B => 2 H2O + NADP(+) + versicolorin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23139", "l": "a primary amine + S-adenosyl-L-methionine <=> a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58265", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54859", "l": "H(+) + NADPH + O2 + octan-3-one <=> ethyl hexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65598", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032442", "l": "phenylcoumaran benzylic ether reductase activity", "d": ["Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68414", "l": "2 H(+) + L-glutamate + NADPH => H2O + L-glutamate 5-semialdehyde + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26016", "l": "3-dehydroquinate => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45872", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49762", "l": "ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O => EDTA + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28638", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106414", "l": "mRNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: mRNA-uracil + NAD(P)+ = mRNA-dihydrouridine + NAD(P)H+ + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39938", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807872", "l": "Active ARF recruits coatomer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607734", "l": "PKC-delta translocates to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38763", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712081", "l": "ALK fusions bind FRS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38730", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050045", "l": "laminaribiose phosphorylase activity", "d": ["Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16946", "l": "(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51468", "l": "(R)-lactate + a quinone = a quinol + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.5.12", "l": "\"D-lactate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749464", "l": "TP53 binds the IKBIP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47653", "l": "D-ribitol 1-phosphate + H2O => phosphate + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975180", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33466", "l": "episterol + H(+) + NADPH + O2 <=> 5-dehydroepisterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30324", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30973", "l": "all-trans-lycopene => 7,7',9,9'-tetra-cis-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042896", "l": "chloramphenicol transmembrane transporter activity", "d": ["Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53294", "l": "H(+) + N-carbamoyl-L-methionine => H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007901", "l": "IL1F10 binds IL1RL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042654", "l": "ecdysis-triggering hormone receptor activity", "d": ["Combining with ecdysis-triggering hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140893", "l": "neutral amino acid, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + amino acid(out) + Na+(out) = H+(out) + amino acid(in) + Na+(in)."], "t": []}, {"i": "TCDB:2.A.18.6.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705729", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12408", "l": "L-lysine + NAD(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49074", "l": "dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O => dibenzothiophene + 2 FMNH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204861", "l": "Interaction of Tie2 and Shc1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19395", "l": "(S)-2-amino-6-oxohexanoate + L-alanine => L-lysine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63365", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73209", "l": "sulfate(in) + sulfite(out) => sulfate(out) + sulfite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51891", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51301", "l": "(9Z)-octadecenoate + L-phenylalanine => H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25267", "l": "2-phenylacetaldehyde + H2O2 + NH4(+) => 2-phenylethylamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193997", "l": "CYP11B1 oxidises 11DCORT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38855", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13790", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20700", "l": "ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72221", "l": "3 hydrogencarbonate(in) + Na(+)(in) => 3 hydrogencarbonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46101", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => cortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25168", "l": "6-hydroxyhexan-6-olide = 6-oxohexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40985", "l": "(9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+) => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028328", "l": "SHC1 bound to activated NTRK2 recruits GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28460", "l": "biotin(out) => biotin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043796", "l": "glyceraldehyde dehydrogenase (NADP) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047955", "l": "glycerol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: A + glycerol = AH(2) + glycerone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.68", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30515", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": [], "t": []}, {"i": "EC:2.5.1.79", "l": "\"thermospermine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52908", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2", "d": [], "t": []}, {"i": "EC:1.13.11.83", "l": "\"4-hydroxy-3-prenylphenylpyruvate oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672173", "l": "Autophosphorylation of PDGFRA extracellular domain dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21559", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine <=> [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102841", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45030", "l": "2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein] => (2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687107", "l": "MAPK4,6 translocate to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404133", "l": "A REH hydrolses atREs to atROL and FAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033509", "l": "USP9X binds Ub:PEX5L (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983152", "l": "Transfer of ubiquitin from E1 to E2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49512", "l": "2-(phosphinatomethylidene)butanedioate + H2O = phosphinomethylisomalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702849", "l": "CALCR binds gepants (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731931", "l": "EDNRA binds selective ERAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40900", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77582", "l": "(9Z)-octadecenoyl-CoA + 1-octanoylglycerol <=> 1-octanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16382", "l": "L-arabinitol + NAD(+) => H(+) + L-xylulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40031", "l": "ent-copalyl diphosphate + H2O = diphosphate + ent-manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76202", "l": "oxalate(in) <=> oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33728", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine => a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102203", "l": "brassicasterol glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol = UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72406", "l": "2-oxoglutarate(out) + urate(in) <=> 2-oxoglutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74712", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine => 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55070", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12233", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) => [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332359", "l": "Active calmodulin binds CAMK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014294", "l": "RAC2 binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656070", "l": "FGFBPs bind FGFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58450", "l": "H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788623", "l": "p-Y-STATs translocate to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045505", "l": "dynein intermediate chain binding", "d": ["Binding to an intermediate chain of the dynein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102664", "l": "indole-3-acetyl-leucine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-leucine + ATP = H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093332", "l": "p-EPHB phosphorylates SDC2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67412", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004344", "l": "glucose dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9658253", "l": "RAS:GTP binds PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683925", "l": "ULK1 is dephosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995334", "l": "COX15 transforms heme O to heme A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30763", "l": "H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.23", "l": "\"valine dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22518", "l": "ADP + H(+) + N-phosphotaurocyamine => ATP + taurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050419", "l": "hydroxymandelonitrile lyase activity", "d": ["Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65400", "l": "butan-1-ol + butanoyl-CoA = butyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65453", "l": "ethanol + hexanoyl-CoA => CoA + ethyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086063", "l": "voltage-gated sodium channel activity involved in SA node cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43052", "l": "3-(methylsulfanyl)propanoate + ATP + CoA = 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.44", "l": "\"3-(methylthio)propionyl--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14283", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate => 2 Fe(III)-[cytochrome c] + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48186", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20649", "l": "23,24-dihydrocucurbitacin B + NADP(+) = cucurbitacin B + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77607", "l": "Formation of stem-loop structure in ApoB mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57842", "l": "1D-myo-inositol 1-phosphate + phosphate => 1D-myo-inositol 1,3-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31876", "l": "(S)-2,3-epoxysqualene => marneral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26532", "l": "(2E)-butenoyl-CoA + H2O => 4-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938174", "l": "PF4 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51836", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65843", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) <=> ATP(in) + Mg(2+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009885", "l": "transmembrane histidine kinase cytokinin receptor activity", "d": ["Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372529", "l": "Release of acetylcholine at the synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2430535", "l": "MASTL phosphorylates ENSA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17645", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33932", "l": "all-trans-zeaxanthin + O2 => (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174551", "l": "Formation of alternative pathway C5 convertase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198813", "l": "GSTO dimers reduce DeHA to AscH- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33876", "l": "cholesteryl (9Z-octadecenoate) + H2O => (9Z)-octadecenoate + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17959", "l": "H2O + propynoate => 3-oxopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26040", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605717", "l": "GM2A binds and mobilizes ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953013", "l": "E2F7 binds E2F8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200396", "l": "Creatine transport across the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001641", "l": "group II metabotropic glutamate receptor activity", "d": ["A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76633", "l": "Ca(2+)(out) + n H(+)(in) => Ca(2+)(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265301", "l": "Corticotropin cleavage from POMC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42223", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58784", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 = a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398184", "l": "LARG activation by G alpha 12/13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48157", "l": "a ganglioside GQ1b (d18:1(4E)) + H2O => a ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203130", "l": "OLR1 binds to oxidized LDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55401", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) => archaeosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592240", "l": "Formation of NRF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74912", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] => a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237129", "l": "Acireductone is created (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61615", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> 7-epi-cylindrospermopsin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52937", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O => (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53110", "l": "2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64180", "l": "an N-(fatty acyl)-L-tryptophan + H2O = a fatty acid + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51546", "l": "D-xylulose => D-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12583", "l": "H2O + NAD(+) + tauropine <=> H(+) + NADH + pyruvate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56000", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322422", "l": "Beta-catenin recruits SMARCA4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11709", "l": "H2O + IMP + NAD(+) => H(+) + NADH + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12294", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Ser) => ATP + L-serine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13385", "l": "3-oxododecanoate + H(+) = 2-undecanone + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.56", "l": "\"3-oxolaurate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47129", "l": "ATP + CoA + deoxycholate => AMP + deoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33565", "l": "(4R)-hydroxysphinganine 1-phosphate + ADP + H(+) => (4R)-hydroxysphinganine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76892", "l": "2-hydroxy-1-phenylethan-1-amine + H2O + NAD(+) => 2-hydroxyacetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647680", "l": "CASP1 cleaves GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76022", "l": "cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54352", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61102", "l": "(2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065959", "l": "An unknown protease degrades hCBXs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47233", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64722", "l": "H(+)(in) + pyruvate(in) => H(+)(out) + pyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75480", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) => S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51473", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68769", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52674", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693356", "l": "CEMIP hydrolyses HA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39864", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170116", "l": "Myt-1 mediated phosphorylation of Cyclin A:Cdc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20842", "l": "CO2 + histamine => H(+) + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15133", "l": "H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36149", "l": "benzyl acetate + CoA => acetyl-CoA + benzyl alcohol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856157", "l": "LAG3 (CD233) binds MHC II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29434", "l": "ATP + phosphate <=> ADP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.7", "l": "\"peroxisome-assembly ATPase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.9", "l": "\"T4 deoxyribonuclease IV\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37512", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10877", "l": "4-hydroxybenzoate + H(+) => CO2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22531", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72431", "l": "(E)-caffeate + ATP + H(+) = (E)-caffeoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71768", "l": "2 Fe(2+) + H(+) + NADP(+) => 2 Fe(3+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202216", "l": "Phosphorylation of SLP-76 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647680", "l": "CASP1 cleaves GSDMD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388605", "l": "POMC(138-176) binds MC2R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029690", "l": "Caspase-6 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174967", "l": "NAT2 acetylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46651", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA <=> androst-4-ene-3,17-dione + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15050", "l": "GDP-alpha-D-glucose + H2O => D-glucose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47977", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26400", "l": "all-trans-zeaxanthin + 2 O2 <=> 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3828025", "l": "DCN (decorin) degradation by MMP14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37127", "l": "2-oxoglutarate + dioxidophosphate + H2O2 = CO2 + H(+) + phosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682863", "l": "RNF168 binds DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018807", "l": "RAC3 GDIs block activation of RAC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20642", "l": "H2O + L-histidinol + 2 NAD(+) => 3 H(+) + L-histidine + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70613", "l": "H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47794", "l": "5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31529", "l": "guanidine + L-glutamate 5-semialdehyde => N(omega)-hydroxy-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16041", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74627", "l": "NADPH + 2 O2 + prefumagillin = acetaldehyde + fumagillin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371590", "l": "HSP70 binds to HSP40:nascent protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46634", "l": "7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12863", "l": "NH4(+) + xanthosine => guanosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0016778", "l": "diphosphotransferase activity", "d": ["Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)."], "t": []}, {"i": "EC:2.7.6.-", "l": "\"Diphosphotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727869", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205262", "l": "Direct recruitment of PI3K to p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.194", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682983", "l": "ATM phosphorylates WHSC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942302", "l": "MMP13 cleaves OPTC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66146", "l": "CoA + H(+) + melatonin => 5-methoxytryptamine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17060", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63854", "l": "(2R)-2-hydroperoxydodecanoate => dodecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340214", "l": "CYGB binds O2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68969", "l": "mandelate + O2 => H2O2 + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067640", "l": "IL6 binds IL6R-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450387", "l": "HuR binds the CRM1 nuclear export machinery (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247849", "l": "WLS dissociates from retromer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37405", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50710", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168857", "l": "Binding of vRNP:M1:NEP complex to CRM1 export receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46226", "l": "(E)-ferulate + CoA + H(+) => (E)-feruloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015486", "l": "glycoside-pentoside-hexuronide:cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25778", "l": "scyllo-inosine => scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44402", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-6 => 3-demethylubiquinol-6 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782637", "l": "HDAC8 deacetylates histones (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102413", "l": "6-O-methyl-deacetylisoipecoside beta-glucosidase activity", "d": ["Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O = 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045430", "l": "chalcone isomerase activity", "d": ["Catalysis of the reaction: a chalcone = a flavanone."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032840", "l": "intramolecular proline-rich ligand binding", "d": ["Binding to a proline-rich region within the same polypeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17743", "l": "3-dehydroshikimate + H(+) + NADH => NAD(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785898", "l": "IL4R binds JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665727", "l": "FMNL2 binds CDC42:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22928", "l": "4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.51", "l": "\"4-acetamidobutyryl-CoA deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707586", "l": "FeHM oxidises LDL,HDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26024", "l": "8'-apo-beta-carotenol + O2 => (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51105", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26219", "l": "abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22954", "l": "(2E)-octenedioyl-CoA + H2O2 => O2 + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66660", "l": "ATP + beta-D-glucosylceramide(in) + H2O = ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418850", "l": "Activation of Cdc42 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56259", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641229", "l": "TLE oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16321", "l": "(S)-indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464822", "l": "RDH12 reduces atRAL to atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191299", "l": "Squalene is oxidized to its epoxide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68048", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine = [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16526", "l": "2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004699", "l": "diacylglycerol-dependent, calcium-independent serine/threonine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium."], "t": []}, {"i": "REACT:R-HSA-5607740", "l": "PKC-delta phosphorylates CARD9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60154", "l": "L-glutamate + L-glutamyl-[protein] => gamma-L-glutamyl-L-glutamyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45985", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112037", "l": "Inactivation of PLC beta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19775", "l": "D-glyceraldehyde 3-phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49849", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68800", "l": "H2O + nigerose = alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13538", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424476", "l": "Activation of RAC1 by VAV2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74857", "l": "(R)-salsolinol-1-carboxylate + H2O => dopamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9821368", "l": "AKAP8L binds MLL1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018814", "l": "RHOT1 hydrolyzes GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12471", "l": "avenacoside A + H2O <=> 26-desgluco-avenacoside A + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679029", "l": "C-ter TLR7 dimer binds HCQ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047913", "l": "gallate 1-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31811", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + viridiflorene", "d": [], "t": []}, {"i": "EC:4.2.3.88", "l": "\"viridiflorene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42025", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) => 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848758", "l": "PTK6 phosphorylates AKT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22202", "l": "(E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014296", "l": "RAC2 GEFs activate RAC2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38863", "l": "phosphate + sucrose 6(F)-phosphate = alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.329", "l": "\"sucrose 6(F)-phosphate phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391913", "l": "FPR2 binds FPR2 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51347", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700149", "l": "Active ALK binds PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60430", "l": "(indol-3-yl)acetate + L-aspartate => (indol-3-yl)acetyl-L-aspartate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043737", "l": "deoxyribonuclease V activity", "d": ["Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28417", "l": "gamma-L-glutamylputrescine + H2O + O2 <=> 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72697", "l": "Start codon recognition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44071", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40234", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56598", "l": "(1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1S,4S)-bornane-2,5-dione + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34715", "l": "15-methylhexadecasphing-4-enine + ATP = 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620837", "l": "CCNG2 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679028", "l": "JAK3 binds JAK3 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60022", "l": "diphosphate + sesquisabinene A => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374663", "l": "DCC interaction with Ezrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53053", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754978", "l": "Unknown kinase phosphorylates RBV-MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110215", "l": "Cleavage of uracil by UNG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22572", "l": "A + H2O + N-methyl-L-glutamate = AH2 + formaldehyde + L-glutamate", "d": [], "t": []}, {"i": "EC:1.5.99.5", "l": "\"methylglutamate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036427", "l": "all-trans-undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP."], "t": []}, {"i": "RHEA:28118", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52279", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0120159", "l": "rRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: a uridine in rRNA = a pseudouridine in rRNA. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."], "t": []}, {"i": "RHEA:54568", "l": "a uridine in rRNA = a pseudouridine in rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675790", "l": "MTORC1 dissociates from ULK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.243", "l": "\"6(G)-fructosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37990", "l": "delta-tocopherol <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40348", "l": "3-oxotetradecanedioyl-CoA + CoA => acetyl-CoA + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51177", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18141", "l": "NAD(+) + trans-cyclohexane-1,2-diol = 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.174", "l": "\"cyclohexane-1,2-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1170539", "l": "Prolactin receptor is internalized (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36083", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160935", "l": "SMURF1 ubiquitinates RHOA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26025", "l": "(3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal => 8'-apo-beta-carotenol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047283", "l": "dolichyl-phosphate D-xylosyltransferase activity", "d": ["Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72521", "l": "6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380233", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044875", "l": "gamma-glutamyl hercynylcysteine sulfoxide synthase activity", "d": ["Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 = gamma-glutamyl-hercynyl cysteine sulfoxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109639", "l": "Formation of the closed pre-initiation complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45865", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77553", "l": "1-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 3-octadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70404", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine => CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.534762107606241", "identifiers": [{"i": "GO:0140358", "l": "P-type transmembrane transporter activity", "d": ["Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71643", "l": "guanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14017", "l": "ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.22", "l": "\"ribosylnicotinamide kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044587", "l": "cellopentaose binding", "d": ["Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39551", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56645", "l": "a uridine in mRNA => a pseudouridine in mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51212", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013143", "l": "RAC1 GEFs activate RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14030", "l": "A + H2O + selenite => AH2 + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64710", "l": "butanal + H(+) + NADPH => butan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44260", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140382", "l": "tryptamine 4-monooxygenase activity", "d": ["Catalysis of the reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25438", "l": "(E,R)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40255", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3R)-hydroxyhexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72443", "l": "(E)-feruloyl-AMP + CoA = (E)-feruloyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37782", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60422", "l": "[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => H2O + triglucosyl-enterobactin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75043", "l": "L-cystine(out) + L-leucine(in) = L-cystine(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050182", "l": "phosphate butyryltransferase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111930", "l": "Adenylate cyclase produces cAMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362465", "l": "GHBP binds GHR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42913", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28218", "l": "chloride + H(+) + H2O2 = H2O + hypochlorous acid", "d": [], "t": []}, {"i": "EC:1.11.2.2", "l": "\"myeloperoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60527", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22599", "l": "cephalosporin C + H2O <=> acetate + deacetylcephalosporin C + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42064", "l": "ATP + GTP = 2',3'-cGAMP + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.86", "l": "\"cyclic GMP-AMP synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64384", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10563", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O <=> 2,5-dioxopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111915", "l": "CAMK4 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72775", "l": "7-carboxymellein + ATP + L-phenylalanine = ADP + H(+) + ochratoxin B + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17672", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798743", "l": "Exocytosis of secretory granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454928", "l": "ABCG4 may mediate cholesterol efflux (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.173", "l": "\"L-rhamnose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39976", "l": "2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983422", "l": "Disassembly of COPII coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19819", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202174", "l": "Activation of ZAP-70 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.15", "l": "\"anhydrosialidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32089", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50747", "l": "2 glyphosate + O2 <=> 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51519", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67594", "l": "(R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71533", "l": "guanine(in) => guanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71437", "l": "an aromatic L-alpha-amino acid(out) + L-thyroxine(in) => an aromatic L-alpha-amino acid(in) + L-thyroxine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42678", "l": "H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide => L-cysteine + L-histidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47100", "l": "choloyl-CoA + taurine = CoA + H(+) + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627056", "l": "Procaspase 9 forms dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43340", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20026", "l": "gibberellin A3 + UDP-alpha-D-glucose => gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30380", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-chamigrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353475", "l": "Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63661", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655170", "l": "RCHY1 monoubiquitinates POLH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029473", "l": "Branching and elongation of mother and daughter filaments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47332", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39902", "l": "7-deoxyloganetin + UDP-alpha-D-glucose <=> 7-deoxyloganin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57370", "l": "(6R)-NADPHX => H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58958", "l": "a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31263", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol = but-3-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38415", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52997", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH => [eIF5A protein]-deoxyhypusine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18390", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44137", "l": "dodecanoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53564", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390597", "l": "Release Of ADP From Myosin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948775", "l": "MKRN1 polyubiquitinates PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047835", "l": "D-tryptophan N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39132", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18925", "l": "L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.20", "l": "\"glucuronolactone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333678", "l": "CPNEs bind PL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38611", "l": "NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11988", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.79", "l": "\"cyclopropane-fatty-acyl-phospholipid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.60", "l": "\"N-acylmannosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41589", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72095", "l": "Internal Methylation of mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76579", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADPH = (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51772", "l": "dimethylallyl diphosphate + phlorisobutanophenone = 4-prenylphlorisobutanophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34301", "l": "2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate => 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40674", "l": "2-iminopropanoate + H2O <=> NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72255", "l": "dopamine + S-adenosyl-L-methionine = 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56613", "l": "L-cysteinyl-[protein] + NAD(+) => H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656891", "l": "OPN1SW binds 11cRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607722", "l": "Active NIK phosphorylates IKKA dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13371", "l": "diphosphate + isoprene => dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37969", "l": "D-galactose + H(+) + NADPH => galactitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51803", "l": "deoxyadlupulone + dimethylallyl diphosphate <=> adlupulone + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58062", "l": "acetaldehyde + H(+) + sulfite => 2-sulfinoacetaldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007860", "l": "RUNX2 binds TWIST1,(TWIST2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68922", "l": "AMP + diphosphate + NADP(+) + pentanal => ATP + H(+) + NADPH + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052766", "l": "mannoside alpha-1,4-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50381", "l": "3 H(+) + 3 malonyl-CoA => 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201603", "l": "Caspase-mediated cleavage of PKC theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787820", "l": "IL34 dimer binds CSF1R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070053", "l": "thrombospondin receptor activity", "d": ["Combining with thrombospondin and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38248", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol => 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995330", "l": "COX10 transforms heme to heme O (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627106", "l": "SMAC (DIABLO) forms dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951910", "l": "RUNX3 binds the RUNX1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70432", "l": "2 H(+)(out) + Li(+)(in) => 2 H(+)(in) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008430", "l": "selenium binding", "d": ["Binding to a selenium (Se) ion."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69463", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine <=> [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005364", "l": "maltose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65292", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate = 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36997", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46188", "l": "an aliphatic nitrile + 2 H2O = a carboxylate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.5.7", "l": "\"aliphatic nitrilase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.207", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733969", "l": "Bile salts dissociate from FABP6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69376", "l": "2-hydroxydodecanoate + O2 = 2-oxododecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69649", "l": "beta-D-glucose + quercetin => H2O + quercetin 4'-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675910", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64453", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42009", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17639", "l": "hop-22(29)-ene => squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695964", "l": "ABHD14B hydrolyses PNPB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21675", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696268", "l": "RND3 binds effectors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799466", "l": "TP53I3 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73156", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) => adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13127", "l": "CoA-glutathione + glutathione => CoA + glutathione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42102", "l": "6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate => ATP + carbamoyl phosphate + H2O + kanamycin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70171", "l": "H(+)(in) + pemetrexed(in) = H(+)(out) + pemetrexed(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352921", "l": "1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75172", "l": "Formation of RAD50:MRE11 complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018642", "l": "chlorophenol 4-monooxygenase activity", "d": ["Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28519", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050105", "l": "L-gulonolactone oxidase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050017", "l": "L-3-cyanoalanine synthase activity", "d": ["Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863008", "l": "Calpain activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034796", "l": "Activated NTRK3 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18549", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.11", "l": "\"glycogen(starch) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68639", "l": "(2E)-geranyl diphosphate <=> diphosphate + sabinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18327", "l": "(+)-amorpha-4,11-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48047", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004768", "l": "stearoyl-CoA 9-desaturase activity", "d": ["Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52098", "l": "9-hydroxy-octadecanoate + H(+) + octadecanoate => 9-octadecanoyloxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29717", "l": "FMN + glycolaldehyde + 2 H(+) + H2O + sulfite => 2-hydroxyethane-1-sulfonate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20545", "l": "H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.9", "l": "\"kynurenine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052654", "l": "L-leucine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003835", "l": "beta-galactoside alpha-2,6-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36658", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine <=> descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22759", "l": "a long-chain primary fatty alcohol + O2 <=> a long-chain fatty aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44618", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38066", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA <=> 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22477", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0106260", "l": "DNA-DNA tethering activity", "d": ["Bridging together two regions of a DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654623", "l": "Activated FGFR3 binds FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34598", "l": "H(+) + isopentadecanoyl-CoA + L-serine <=> 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.-", "l": "\"Other carbon-carbon lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30093", "l": "a ubiquinol + NH4(+) + pyruvate => a ubiquinone + D-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64211", "l": "an N-(fatty acyl)-L-glutamine + H2O <=> a fatty acid + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58759", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388560", "l": "EDNRA,EDNRB bind EDNs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822185", "l": "HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60687", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44029", "l": "L-altrarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770129", "l": "Formation of the Spliceosomal A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948136", "l": "ULK1 Translocates to the mitochondria (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198599", "l": "AKT phosphorylates MDM2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32204", "l": "(R)-synephrine => (4-hydroxyphenyl)acetaldehyde + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53895", "l": "an S-prenyl-L-cysteine + H2O + O2 <=> a prenal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102482", "l": "5-deoxy-D-glucuronate isomerase activity", "d": ["Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20681", "l": "cis-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.215", "l": "\"cis-zeatin O-beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183051", "l": "CBL ubiquitinates Sprouty (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.92", "l": "\"fatty acid alpha-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71125", "l": "AMP + 2 CO2 + 2 CoA + diphosphate + hispidin => (E)-caffeate + ATP + H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68064", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333051", "l": "RPA1 binds HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806732", "l": "GNLY binds the bacterial cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236970", "l": "Proteasomal clevage of exogenous antigen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41763", "l": "a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30359", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 = chlorophyllide b + 3 H2O + 2 NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.122", "l": "\"chlorophyllide a oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28202", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.7", "l": "\"ferredoxin:protochlorophyllide reductase (ATP-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67455", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O <=> 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160107", "l": "tRNA (adenine(58)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22040", "l": "H2O + N-formyl-L-aspartate = formate + L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.1.8", "l": "\"formylaspartate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69005", "l": "Cdc6 protein is phosphorylated by CDK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10454", "l": "(R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047265", "l": "poly(glycerol-phosphate) alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67148", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 = 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835328", "l": "NPM binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748996", "l": "GST dimers cleave AZA to 6MP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45936", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51955", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696960", "l": "USP49 deubiquitinates H2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65686", "l": "a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424476", "l": "Activation of RAC1 by VAV2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392748", "l": "L1 binds to AP-2 Clathrin complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46400", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42253", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA => 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23767", "l": "diphosphate + L-serine <=> H(+) + O-phospho-L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52067", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444433", "l": "Cho transports from the extracellular space to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63763", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47254", "l": "6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64835", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA <=> 3-hydroxy-benzyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28430", "l": "D-allose 6-phosphate = D-allulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954056", "l": "E2F6 binds TFDP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44669", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73248", "l": "ladanein + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74733", "l": "Insulin receptor de-phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18864", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46424", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69194", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48886", "l": "3,8-divinyl protochlorophyllide a + H(+) + NADPH => NADP(+) + protochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10763", "l": "citrate <=> acetate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12538", "l": "CO2 + H2O + L-phenylalanine => H(+) + L-arogenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.37", "l": "\"pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70324", "l": "2,3-dioxo-L-gulonate => 2-carboxy-L-lyxonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27614", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52528", "l": "2-oxoglutarate + L-asparagine = 2-oxosuccinamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018746", "l": "RHOQ binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10622", "l": "(E)-cinnamoyl-CoA + H(+) + NADPH => (E)-cinnamaldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22168", "l": "UDP-alpha-D-glucose = UDP-alpha-D-galactose", "d": [], "t": []}, {"i": "EC:5.1.3.2", "l": "\"UDP-glucose 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65994", "l": "5,6-trans-vitamin D3 => calciol + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58358", "l": "CO2 + formaldehyde + L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626816", "l": "PIN1 binds p-S345-NCF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17854", "l": "keto-L-sorbose + O2 => 5-dehydro-D-fructose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375161", "l": "NCAM1 trans-homophilic interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533970", "l": "NID1 degradation by MMP3, 7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0000150", "l": "DNA strand exchange activity", "d": ["Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA."], "t": []}, {"i": "REACT:R-HSA-912458", "l": "Formation of meiotic heteroduplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27907", "l": "butanoyl-CoA + NADP(+) => (2E)-butenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993769", "l": "Transfer of SUMO3 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58376", "l": "decan-1-ol + NADP(+) = decanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853391", "l": "GlcNAc (Man)5 translocates from cytosol to lysosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59889", "l": "4-chloro-L-lysine + AH2 + O2 => A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39727", "l": "a sphingomyelin(in) = a sphingomyelin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0003721", "l": "telomerase RNA reverse transcriptase activity", "d": ["Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034544", "l": "trans-ACOHDA hydrolase activity", "d": ["Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429992", "l": "PARN deadenylates mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981832", "l": "NMUR2 binds neuromedin-S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008120", "l": "ceramide glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57919", "l": "ATP + L-aspartyl-tRNA(Asn) <=> 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667914", "l": "ALK binds ligand midkine (MDK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71516", "l": "hypoxanthine(out) => hypoxanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804006", "l": "NO and NO2 react to N2O3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840949", "l": "ARSA removes sulfate from SM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665998", "l": "MKL1 binds SRF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74900", "l": "(2E)-2-butenoate + ATP + holo-[ACP] => (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22861", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350598", "l": "Arginine<=>Agmatine+CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12181", "l": "anthranilate + S-adenosyl-L-methionine => H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47466", "l": "(2E,5Z)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68472", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40503", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871266", "l": "YAP1 binds TEAD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50479", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] <=> CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948583", "l": "miR-17 microRNA binds CNOT6L mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419843", "l": "CALCA(83-119) binds CALCR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036443", "l": "dermatan 6-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35449", "l": "H(+) + NADPH + norsolorinic acid => (1'S)-averantin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197690", "l": "Detachment of WASP/WAVE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473594", "l": "Collagen type II degradation by MMP15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72013", "l": "glutathione(out) + urate(in) => glutathione(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23261", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14137", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine = 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.13", "l": "\"psychosine sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35166", "l": "H(+)(out) + minocycline(in) <=> H(+)(in) + minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699574", "l": "FOXO3-dependent BCL2L11 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653840", "l": "POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69142", "l": "Recruitment of Dna2 endonuclease (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66872", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42769", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21641", "l": "NADP(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49334", "l": "2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977959", "l": "ERBB4 forms heterodimers with EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43890", "l": "[sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine => [sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672980", "l": "Dissociation of RAS:RAF complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008963", "l": "phospho-N-acetylmuramoyl-pentapeptide-transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21552", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001052", "l": "plastid PEP RNA polymerase core enzyme binding", "d": ["Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43939", "l": "androst-5-ene-3,17-dione <=> androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50116", "l": "eicosanoyl-CoA + taurine = CoA + H(+) + N-eicosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044692", "l": "exoribonuclease activator activity", "d": ["Binds to and increases the activity of an exoribonuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783880", "l": "PIPOX oxidises PPCA to P6C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51641", "l": "(9Z,12Z)-octadecadienoate + O2 => (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29827", "l": "Mg(2+)(in) = Mg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13422", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate => an N-acylneuraminate 9-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71391", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14221", "l": "H2O + monomethyl sulfate = H(+) + methanol + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.16", "l": "\"monomethyl-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718379", "l": "GNRHR binds chemical antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63409", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 => 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10380", "l": "diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": [], "t": []}, {"i": "EC:2.4.2.10", "l": "\"orotate phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44801", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) => 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57817", "l": "dGMP + H2O => 2-deoxy-D-ribose 5-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099582", "l": "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830762", "l": "Expression of WNT11 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48166", "l": "H(+) + red chlorophyll catabolite => epoxypheophorbide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791016", "l": "SFTPB binds itself (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.129", "l": "\"acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44264", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48828", "l": "H(+) + NADPH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.219", "l": "\"resorcinol 4-hydroxylase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49147", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49327", "l": "(5R,6S)-5,6-epoxi-capsanthin <=> all-trans-capsorubin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805811", "l": "Release of SEPT4 from mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60325", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001054", "l": "RNA polymerase I activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36895", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73047", "l": "guanidinoacetate(in) = guanidinoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177930", "l": "GAB1 phosphorylation by EGFR kinase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70963", "l": "D-phenylalanine + H2O + O2 = 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54875", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 <=> (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868236", "l": "BAR domain proteins recruit dynamin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686061", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.251", "l": "\"lipid IVA palmitoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39480", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60846", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate => a 5'-end diphospho-guanosine in mRNA + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17025", "l": "NADP(+) + xylitol = H(+) + L-xylulose + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.10", "l": "\"L-xylulose reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109813", "l": "GRB2-1 binds SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012835", "l": "GDIs block activation of RHOA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34437", "l": "4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine => 4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73909", "l": "ADP + aeruginascin + H(+) => 4-hydroxy-N,N,N-trimethyltryptamine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30564", "l": "dimethylallyl diphosphate + L-tryptophan => 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17674", "l": "quercetin + S-adenosyl-L-methionine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50327", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676595", "l": "TRAFs bind RANK:RANKL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029451", "l": "Activation of RAC1 by VAV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53186", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667965", "l": "ANKLE2 binds PP2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592278", "l": "Autocatalytic activation of proMMP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46331", "l": "L-threo-3-phenylserine <=> 3-phenylpyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57383", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15754", "l": "GTP + IMP + L-aspartate => GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43048", "l": "keto-D-tagatose = keto-D-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32790", "l": "ATP + H2O + L-ectoine(out) <=> ADP + H(+) + L-ectoine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35102", "l": "fusidate(in) + H(+)(out) <=> fusidate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74024", "l": "L-alanine(in) + L-serine(out) => L-alanine(out) + L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429157", "l": "ABCC4 accumulation of dense granule contents (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41704", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60932", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070742", "l": "C2H2 zinc finger domain binding", "d": ["Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696810", "l": "RNase P cleaves the 5' end of pre-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15691", "l": "CO2 + propane-1,3-diamine => H(+) + L-2,4-diaminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607753", "l": "CARD9 oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39917", "l": "1-O-alkyl-sn-glycerol + phosphate => 1-O-alkyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40650", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36152", "l": "(E)-cinnamyl alcohol + acetyl-CoA => (E)-cinnamyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54210", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77056", "l": "cyclopentylamine + H2O + NADP(+) => cyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54485", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20457", "l": "D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033708", "l": "isocitrate-homoisocitrate dehydrogenase activity", "d": ["Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166082", "l": "IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52815", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507871", "l": "Aquaporins passively transport glycerol out of cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44781", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine => H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655170", "l": "RCHY1 monoubiquitinates POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20041", "l": "3-oxopropanoate + H2O + NADP(+) = 2 H(+) + malonate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71453", "l": "bradykinin(1-7) + L-Phe-L-Arg => bradykinin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37360", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018768", "l": "RHOU auto-activates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74171", "l": "an N-methyl carbamate ester + H(+) + H2O = an alcohol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73830", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65775", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785898", "l": "IL4R binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193643", "l": "PRDM4 (SC1) binds to p75NTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011224", "l": "ROBO3.1 binds DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67931", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O <=> a 3'-end 3'-phosphouridine-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47158", "l": "7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH => 7alpha,25-dihydroxycholesterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27453", "l": "iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41732", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.1", "l": "\"glycogen phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58090", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+) => 1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68041", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH => (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12155", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene <=> (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31290", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA <=> acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070773", "l": "protein-N-terminal glutamine amidohydrolase activity", "d": ["Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426152", "l": "SREBP1A,2 binds the IDI1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54856", "l": "H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.36", "l": "\"acetoacetyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451649", "l": "TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10211", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) <=> H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444511", "l": "Formation of MSH2:MSH3 Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66268", "l": "CoA + nonanoyl-AMP = AMP + H(+) + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211164", "l": "AKT phosphorylates FOXO1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086060", "l": "voltage-gated sodium channel activity involved in AV node cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.59", "l": "\"tryptophan 6-halogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74258", "l": "XDH oxidizes xanthine to form urate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018520", "l": "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677050", "l": "Formation of the GCN5-ATAC complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467794", "l": "Resolution of sister chromatids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874087", "l": "SGT1 binds HSP90 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21657", "l": "CDP-alpha-D-paratose => CDP-3,6-dideoxy-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.104", "l": "\"3-dehydro-4-phosphotetronate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609921", "l": "SGTA binds Tail-anchored protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612076", "l": "p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0061598", "l": "molybdopterin adenylyltransferase activity", "d": ["Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49078", "l": "dibenzothiophene 5-oxide + FMN + H(+) + H2O => dibenzothiophene + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696131", "l": "AOC1 deaminates Hist (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65237", "l": "3-methylbutanol + acetyl-CoA => 3-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66113", "l": "2-oxobutanoate + L-tyrosine => (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016929", "l": "deSUMOylase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190141", "l": "ALAD binds to Pb2+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39044", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13548", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54117", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + pseudolaratriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39449", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63031", "l": "(15Z)-tetracosenamide + H2O <=> (15Z)-tetracosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72242", "l": "estrone 3-sulfate(out) + L-glutamate(in) <=> estrone 3-sulfate(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72611", "l": "H(+)(out) + L-alanyl-L-lysine(out) = H(+)(in) + L-alanyl-L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.66", "l": "\"choriolysin L\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797100", "l": "CCNK binds CDK13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54542", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071074", "l": "eukaryotic initiation factor eIF2 binding", "d": ["Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30217", "l": "a menaquinone + H2O + nitrous oxide => a menaquinol + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32095", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.197", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797553", "l": "Protein 4.1 binds CASK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202137", "l": "AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39146", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952996", "l": "E2F7 forms homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37334", "l": "H2O + L-methionyl-L-alanine <=> L-alanine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202731", "l": "JAM3 dimerises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59254", "l": "(E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619843", "l": "ERKs phosphorylate RSKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23838", "l": "4-methylsulfanyl-2-oxobutanoate + L-alanine => D-methionine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62518", "l": "a ganglioside GA2 + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102428", "l": "kaempferol-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose = kaempferol-3-gentiobioside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183032", "l": "Expression of GLUT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29667", "l": "H2O(in) = H2O(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42611", "l": "a plastoquinone + (n+1) H(+)(in) + NADH <=> a plastoquinol + n H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33706", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604763", "l": "Autocatalytic activation of MMP7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211405", "l": "Anthrax lef cleaves target cell MAP2K6 (MEK6) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20019", "l": "5,10-methylenetetrahydromethanopterin + H(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51455", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate <=> beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55403", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) <=> archaeosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50964", "l": "cytidine(8) in tRNA + H(+) + H2O = NH4(+) + uridine(8) in tRNA", "d": [], "t": []}, {"i": "EC:3.5.4.35", "l": "\"tRNA(cytosine(8)) deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25170", "l": "6-oxohexanoate + H(+) => 6-hydroxyhexan-6-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29882", "l": "ATP + H2O + L-arginine(out) <=> ADP + H(+) + L-arginine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659820", "l": "RB1 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877153", "l": "STARD7 binds PC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0099589", "l": "serotonin receptor activity", "d": ["Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53654", "l": "(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033149", "l": "FFAT motif binding", "d": ["Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74895", "l": "nitric oxide(out) = nitric oxide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690023", "l": "NUBPL binds 4Fe-4S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48343", "l": "a medium chain fatty acid + ATP + CoA <=> a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46439", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031489", "l": "myosin V binding", "d": ["Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848829", "l": "CBL autoubiquitinates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696274", "l": "RND1 binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179417", "l": "Multiubiquitination of Nek2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70763", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37576", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635842", "l": "ULK3 phosphorylates GLI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167085", "l": "Formation of DSIF:NELF:HIV-1 early elongation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917700", "l": "MVB Vesicle Formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783681", "l": "LIF binds LIFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560789", "l": "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24673", "l": "H2O + hypoxanthine + NAD(+) <=> H(+) + NADH + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679239", "l": "ULK complex translocates to the ER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75153", "l": "diphosphate + neoverrucosan-5beta-ol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031078", "l": "histone H3K14 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42335", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12888", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) <=> GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008750", "l": "NAD(P)+ transhydrogenase (AB-specific) activity", "d": ["Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832009", "l": "M2-1 tetramer gets phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14303", "l": "4-pyridoxate + H(+) => 4-pyridoxolactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31581", "l": "(5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31274", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39491", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22883", "l": "2-oxoglutarate + L-arogenate <=> L-glutamate + prephenate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050219", "l": "prostaglandin-A1 delta-isomerase activity", "d": ["Catalysis of the reaction: prostaglandin A1 = prostaglandin C1."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052722", "l": "fatty acid in-chain hydroxylase activity", "d": ["Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50441", "l": "prostaglandin H1 => prostaglandin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15426", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23382", "l": "H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33827", "l": "ergosterol = vitamin D2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374680", "l": "L1 trans-homophilic interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75464", "l": "choline(out) + n H(+)(in) => choline(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63906", "l": "H2O + phenguignardate => 2 3-phenylpyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28154", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27529", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007220", "l": "E2F6:TFDP1/2 binds the E2F1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018808", "l": "RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50790", "l": "(E)-pent-3-en-2-one + H(+) + NADPH => NADP(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938199", "l": "RUNX1:CBFB binds the MYL9 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32048", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70198", "l": "ATP + deamido-NAD(+) <=> ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013023", "l": "RHOB GEFs activate RHOB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980691", "l": "RHOA GEFs activate RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57929", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27909", "l": "butanoyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49790", "l": "CoA + glycochenodeoxycholate + H(+) => chenodeoxycholoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34592", "l": "Co-precorrin-7 + S-adenosyl-L-methionine => Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64112", "l": "an N-acyl-L-phenylalanine + H2O = a fatty acid + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72704", "l": "UDP-alpha-D-galactose(in) + UMP(out) => UDP-alpha-D-galactose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57802", "l": "4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite => 2,3-dinitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26543", "l": "(R)-piperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15910", "l": "2-oxoglutarate + O2 + taurine => aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73567", "l": "ITP(out) + UTP(in) = ITP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57546", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36412", "l": "7-dehydrocholesterol + hnu => calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61546", "l": "ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35120", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O => bisdemethoxycurcumin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73805", "l": "diphosphate + isoechinulin B => dimethylallyl diphosphate + neoechinulin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48984", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30986", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62024", "l": "campesteryl 3-beta-D-glucoside + H2O = campesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42926", "l": "2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56123", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983156", "l": "Polyubiquitination of substrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46686", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2 => 3-oxochol-4-en-24-oyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204600", "l": "Basigin homodimerises (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265301", "l": "Corticotropin cleavage from POMC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848339", "l": "PNPLA5 hydrolyzes TAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103083", "l": "methylthiobutylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(4'-methylthio)butylmalate = 3-(4'-methylthio)butylmalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693347", "l": "CRYM reduces P2C to PPCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23593", "l": "glycerol + NADP(+) => D-glyceraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49402", "l": "phosphate + validoxylamine A => H2O + validoxylamine A 7'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002058", "l": "uracil binding", "d": ["Binding to uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.76", "l": "\"prenyl-diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48011", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727922", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912374", "l": "Transport of NOTCH precursor to Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782943", "l": "UV-DDB ubiquitinates XPC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22736", "l": "5-formimidoyltetrahydrofolate + 2 H(+) = (6R)-5,10-methenyltetrahydrofolate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.4", "l": "\"formimidoyltetrahydrofolate cyclodeaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13995", "l": "2-methyl-3-oxopropanoate + L-glutamate => (S)-3-amino-2-methylpropanoate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36192", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41468", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.122", "l": "\"oryzalexin E synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72685", "l": "cholate(in) => cholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52995", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine <=> [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19015", "l": "dTDP + H(+) + phosphate => dTTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35869", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49143", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.77", "l": "\"snapalysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51853", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63721", "l": "losartan + UDP-alpha-D-glucuronate => losartan-2-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.182", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804762", "l": "TP53 forms homotetramers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015067", "l": "amidinotransferase activity", "d": ["Catalysis of the reversible transfer of an amidino group to an acceptor."], "t": []}, {"i": "EC:2.1.4.-", "l": "\"Amidinotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71506", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55292", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.257", "l": "\"tRNA (pseudouridine(54)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14491", "l": "a nucleoside 2'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.-.-", "l": "\"Enzymes using H2 as reductant\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614773", "l": "MBP gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12512", "l": "D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38527", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24367", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49717", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 => 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10220", "l": "ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": [], "t": []}, {"i": "EC:6.1.1.1", "l": "\"tyrosine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75820", "l": "(5Z,8Z)-octadecadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938231", "l": "RUNX1:CBFB binds CREBBP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209129", "l": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72487", "l": "citrate(out) + phosphoenolpyruvate(in) = citrate(in) + phosphoenolpyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26496", "l": "7-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622129", "l": "FABP5 binds atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004419", "l": "hydroxymethylglutaryl-CoA lyase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29512", "l": "(2E,6E)-farnesyl diphosphate => (+)-valencene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20462", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679028", "l": "JAK3 binds JAK3 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788061", "l": "Fibronectin degradation by ADAM8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001631", "l": "cysteinyl leukotriene receptor activity", "d": ["Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191656", "l": "Closure of gap junction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70274", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678327", "l": "MIOX oxidises Ins to GlcA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35944", "l": "brevianamide F + dimethylallyl diphosphate => deoxybrevianamide E + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23641", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 => CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42273", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9833635", "l": "p-PKR dimer localizes to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14767", "l": "CO2 + excited coelenteramide h monoanion + H(+) + hnu => coelenterazine h + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071558", "l": "histone H3K27me2/H3K27me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64513", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12122", "l": "ADP-alpha-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58665", "l": "(S)-2-hydroxyglutarate + a quinone => 2-oxoglutarate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31949", "l": "ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68649", "l": "2 L-cysteine => H(+) + hydrogen sulfide + L-lanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66850", "l": "2 Cu(+) + H(+) + NAD(+) => 2 Cu(2+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18048", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O <=> alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381644", "l": "ER calcium channels open in response to activated PKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61299", "l": "5-deoxy-alpha-D-ribose 1-phosphate <=> 5-deoxy-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41152", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23035", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22988", "l": "3-oxopropanoate + CoA + NADP(+) = acetyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50189", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54488", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52638", "l": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate => 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50730", "l": "4-hydroxyphenylacetonitrile + H2O => (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53491", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50174", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110218", "l": "Cleavage of uracil by TDG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708275", "l": "PDE4A binds PDE4A inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10758", "l": "AMP + diphosphate + H(+) + phosphoenolpyruvate => ATP + phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757954", "l": "N4BP1 binds IKBKG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35675", "l": "H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-210444", "l": "L-Glutamate loading of synaptic vesicle (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14486", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-juneol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50961", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73937", "l": "desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase] => griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937807", "l": "SRC phosphorylates RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246478", "l": "APOM binds retinoids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62067", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12848", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O <=> [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53653", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008780", "l": "acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5138459", "l": "WNT5A:FZD4 is endocytosed (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18928", "l": "L-gulono-1,4-lactone + NADP(+) <=> D-glucurono-3,6-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57154", "l": "(3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38879", "l": "a fatty acid(in) = a fatty acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36873", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50875", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 <=> (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46701", "l": "(R)-lipoate + GTP + H(+) => (R)-lipoyl-GMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24196", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13954", "l": "a D-aminoacyl-tRNA + H2O => a D-alpha-amino acid + a tRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18810", "l": "L-alanine + oxomalonate => aminomalonate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696275", "l": "RND2 binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707505", "l": "Hemes bind to CLEC1B dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26345", "l": "L-galactonate + NADP(+) = aldehydo-D-galacturonate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.365", "l": "\"D-galacturonate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24620", "l": "NAD(+) + octan-1-ol = H(+) + NADH + octanal", "d": [], "t": []}, {"i": "EC:1.1.1.73", "l": "\"octanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42092", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013109", "l": "RHOC GEFs activate RHOC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645481", "l": "TIFA oligomerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987039", "l": "JAK1 binds IL20RA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693598", "l": "ATM phosphorylates NBN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30532", "l": "biotinate sulfoxide + H(+) + NADH => biotin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102174", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800298", "l": "HGF dimer binds MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961972", "l": "E2F1 binds the RRM2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60487", "l": "CTP + UTP <=> cyclic CMP-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71340", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) => chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50856", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34580", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D => 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20531", "l": "2-cis-(+)-abscisate + H(+) + H2O2 => 2-cis-(+)-abscisic aldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65527", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18940", "l": "an N-acyl-L-homoserine lactone + H2O <=> a carboxylate + L-homoserine lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55456", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71101", "l": "androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in) => androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76760", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,5-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41513", "l": "L-ornithine + NADH + O2 => H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.150", "l": "\"lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42487", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683925", "l": "ULK1 is dephosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30392", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine => 2-oxoglutaramate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40697", "l": "1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13868", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol <=> beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16926", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine => (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41055", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27631", "l": "ethylene glycol + NAD(+) => glycolaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59745", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22877", "l": "(R)-mandelamide + H2O => (R)-mandelate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419644", "l": "Transphosphorylation of pLIMK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218836", "l": "PTK2beta binds alphaVbeta3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57235", "l": "GDP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10134", "l": "AMP + benzoyl-CoA + diphosphate => ATP + benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032798", "l": "DOCK3 activates RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47644", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573294", "l": "Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17026", "l": "NADP(+) + xylitol => H(+) + L-xylulose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51032", "l": "7-chloroindole-3-pyruvate imine dimer = dichlorochromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728752", "l": "TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69622", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43433", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] => butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21671", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) <=> ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16878", "l": "3-sulfino-L-alanine + H(+) => CO2 + hypotaurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024630", "l": "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.95", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73804", "l": "dimethylallyl diphosphate + neoechinulin B => diphosphate + isoechinulin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44784", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine = H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74887", "l": "2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16993", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] = 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}, {"i": "EC:1.8.2.6", "l": "\"S-disulfanyl-L-cysteine oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75843", "l": "ergothioneine(out) + Na(+)(out) = ergothioneine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35947", "l": "dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.100", "l": "\"chanoclavine-I aldehyde reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64226", "l": "5-hydroxyuridine(34) in tRNA + A + H2O => AH2 + O2 + uridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40333", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44851", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24664", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10340", "l": "(2E,6E)-farnesyl diphosphate = (-)-vetispiradiene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.21", "l": "\"vetispiradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050389", "l": "uronolactonase activity", "d": ["Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0015459", "l": "potassium channel regulator activity", "d": ["Binds to and modulates the activity of a potassium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70410", "l": "[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 <=> (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192830", "l": "Viral Polymerase Assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54469", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50520", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805122", "l": "AURKB binds TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444191", "l": "GPR120 is a receptor for unsaturated long-chain free fatty acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31074", "l": "(S)-2-methyl-3-oxopropanoate + L-alanine <=> (S)-3-amino-2-methylpropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14186", "l": "3-phenylpyruvate + H(+) => 2-phenylacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023455", "l": "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.116", "l": "\"3-hydroxypropionyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102507", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798749", "l": "Exocytosis of specific granule lumen proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51858", "l": "(2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14864", "l": "(S)-dihydroorotate + NADP(+) <=> H(+) + NADPH + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50004", "l": "H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.231", "l": "\"tetracycline 11a-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66374", "l": "glycerol + phosphate => H2O + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49178", "l": "12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71137", "l": "H(+)(out) + L-histidine(in) + Na(+)(in) => H(+)(in) + L-histidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139941", "l": "Binding of IP3 to IP3 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66698", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853429", "l": "PHLDA1 binds AURKA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.4", "l": "\"phosphatidate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60090", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADPH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204600", "l": "Basigin homodimerises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54416", "l": "5alpha-campestan-3-one + NADP(+) = campest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31865", "l": "friedelin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65022", "l": "CoA + H(+) + N(2)-succinyl-L-ornithine => L-ornithine + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18318", "l": "an L-alpha-amino acid => a D-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17882", "l": "H2O + N-sulfo-D-glucosamine => D-glucosamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18984", "l": "(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36970", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11879", "l": "NAD(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.102", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49819", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine <=> 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59785", "l": "H2O + NADP(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74536", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70806", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805103", "l": "AURKA phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25098", "l": "ATP + UDP = ADP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29590", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610036", "l": "Defective GALE does not epimerise UDP-Gal to UDP-Glc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32829", "l": "ADP + H(+) + methionine(in) + phosphate => ATP + H2O + methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75891", "l": "Abortive Initiation After Second Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11989", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67464", "l": "H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36082", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56721", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34517", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP => tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874082", "l": "MET phosphorylates PTK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001608", "l": "G protein-coupled nucleotide receptor activity", "d": ["Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12112", "l": "indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.47", "l": "\"indolepyruvate C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66704", "l": "H2O + mycophenolyl-CoA = CoA + H(+) + mycophenolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72871", "l": "anthocyanin A3 + malonyl-CoA = anthocyanin A5 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54294", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate => ATP + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55092", "l": "D-fructose + UDP-alpha-D-glucose = H(+) + sucrose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34231", "l": "5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40400", "l": "1,2-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18387", "l": "acetoacetate + 2 AMP + 4 H(+) + 4 phosphate => acetone + 2 ATP + 3 H2O + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186819", "l": "SH2 domain of Src binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51000", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine = [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.259", "l": "\"[fructose-bisphosphate aldolase]-lysine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5246478", "l": "APOM binds retinoids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138459", "l": "WNT5A:FZD4 is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74705", "l": "5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33424", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) => diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16715", "l": "glutathione + H(+) + succinate => H2O + S-succinylglutathione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57268", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55884", "l": "[aequorin] + 3 Ca(2+) = [aequorin]--dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10707", "l": "ATP + L-valine + tRNA(Val) <=> AMP + diphosphate + L-valyl-tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031151", "l": "histone H3K79 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45953", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose => H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.1", "l": "\"unspecific peroxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11049", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid => 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32401", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2R,4S)-neodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26501", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.78", "l": "\"GDP-D-glucose phosphorylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55102", "l": "(3R)-hydroxypentanoyl-[ACP] + NADP(+) => 3-oxopentanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30600", "l": "15-cis-phytoene + 3 A => 3 AH2 + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33567", "l": "A + ethanol = acetaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61705", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine => AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167459", "l": "Abortive  termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21605", "l": "styrene oxide => 2-phenylacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16597", "l": "ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27932", "l": "(R)-4'-phosphopantothenate + AMP + diphosphate + H(+) => (R)-4-phosphopantoate + ATP + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196753", "l": "2xPPCS ligates PPanK with Cys (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50706", "l": "H(+) + NADH + propanal => 1-propanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029272", "l": "Release of PLCG from FCGR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21779", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45881", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16783", "l": "a fatty acid + CoA + H(+) => a fatty acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32919", "l": "H2O + methyl (indol-3-yl)acetate = (indol-3-yl)acetate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090417", "l": "N-methylnicotinate transmembrane transporter activity", "d": ["Enables the transfer of N-methylnicotinate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688294", "l": "SIRT5 deacetylates Cytochrome C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47162", "l": "3-dehydro-4-methylzymosterol + CO2 + NADH => 4beta-methylzymosterol-4alpha-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11944", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799246", "l": "CHEK1 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75762", "l": "(9Z,11E)-octadecadienoate + H2O <=> 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045300", "l": "acyl-[acyl-carrier-protein] desaturase activity", "d": ["Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823354", "l": "Protein N forms hendecamers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63596", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675656", "l": "EDA:EDAR binds EDARADD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840334", "l": "PSAP gets cleaved (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784861", "l": "HSPG binds LPL dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52061", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875531", "l": "MET binds TNS4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047221", "l": "sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851011", "l": "TRIM27 polyubiquitinates PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73163", "l": "FAD(out) + NAD(+)(in) = FAD(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67599", "l": "heptadecasphing-4-enine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71872", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) => (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16616", "l": "acetyl-CoA + an arylamine <=> an N-acetylarylamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718379", "l": "GNRHR binds chemical antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411383", "l": "NLK phosphorylates TCF/LEF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43973", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377640", "l": "Autophosphorylation of SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995334", "l": "COX15 transforms heme O to heme A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27512", "l": "dehydro coenzyme F420-0 + GMP + H(+) => 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73577", "l": "CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389463", "l": "Proteinase-activated receptors can bind thrombin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20907", "l": "(S)-2-hydroxypropyl-coenzyme M <=> (S)-1,2-epoxypropane + coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681616", "l": "AP2 binds chlorpromazine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.3", "l": "\"plus-end-directed kinesin ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47326", "l": "3-oxo-3-phenylpropanoate + L-alanine => (S)-3-amino-3-phenylpropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0004129", "l": "cytochrome-c oxidase activity", "d": ["Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41864", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390453", "l": "Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047187", "l": "deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity", "d": ["Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30244", "l": "4 L-ascorbate + O2 => 2 H2O + 4 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0004035", "l": "alkaline phosphatase activity", "d": ["Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58987", "l": "acrolein + H2O + O2 <=> acrylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912627", "l": "CBL ubiquitinates PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42488", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III = 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64546", "l": "8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676257", "l": "Formation of the SET1A complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48371", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810643", "l": "EPPIN protein complex binds bacteria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11856", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164832", "l": "ATPase synthesizes ATP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785711", "l": "Telomere shortening during replicative exhaustion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61140", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + myricetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67091", "l": "ATP + H2O + tetracosanoate(in) <=> ADP + H(+) + phosphate + tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166538", "l": "The bound receptor dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388832", "l": "PI3K binds CD28 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83677", "l": "C4 deamination of cytidine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41354", "l": "a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17558", "l": "anthranilate + malonyl-CoA => CoA + N-malonylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58574", "l": "H2O2 + precondylocarpine acetate => O-acetyl-15alpha-stemmadenine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162914", "l": "Myristoylation of Nef (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679205", "l": "ULK1 phosphorylates Beclin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.4", "l": "\"acyl-lipid (11-3)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938371", "l": "RUNX2:CBFB binds the LGALS3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60001", "l": "hydroxymethylphosphonate + O2 => formate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17226", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] => 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102582", "l": "cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose = cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102925", "l": "solanine UDP-galactose galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445069", "l": "L1-EGFR trans-heterodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37689", "l": "1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000074", "l": "TCN2 binds RCbl in the circulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71783", "l": "MDH2 reduces OA to MAL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45625", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine => AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31110", "l": "3-phenylpyruvate + O2 <=> (2-hydroxyphenyl)acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54573", "l": "a uridine in tRNA => a pseudouridine in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58166", "l": "7-epi-ent-eudesmane-5,11-diol + diphosphate => (2E,6E)-farnesyl diphosphate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62068", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65589", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58930", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + H2O => (3R,4R)-7,2',4'-trihydroxyisoflavanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821931", "l": "BOD1L1 binds SET1A complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68753", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73190", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate <=> (2R,3S,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008470", "l": "isovaleryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050293", "l": "steroid-lactonase activity", "d": ["Catalysis of the reaction: H2O + testololactone = H+ + testolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0000703", "l": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451377", "l": "Interaction of IQGAP1 with nephrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022728", "l": "FKBP5 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16826", "l": "ATP + uridine => ADP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65178", "l": "AH2 + protoaustinoid B => A + protoaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22993", "l": "3-oxopropanoate + CoA + NAD(+) => acetyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444691", "l": "Prokineticin receptors bind prokineticin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66288", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73972", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607751", "l": "TRAF6 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33800", "l": "L-histidinol + NAD(+) => H(+) + L-histidinal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76456", "l": "(E)-coniferol + A => (E)-coniferaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48654", "l": "20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41340", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170149", "l": "Translocation of active Cdc25C to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24753", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite => 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57244", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13075", "l": "guanosine 3',5'-bis(diphosphate) + H(+) + phosphate => guanosine 3'-diphosphate 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19734", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) => bacteriochlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13506", "l": "choline + O2 => betaine aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36125", "l": "gibberellin A20 methyl ester + S-adenosyl-L-homocysteine => gibberellin A20 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16073", "l": "2,2-dialkylglycine + H(+) + pyruvate = CO2 + dialkyl ketone + L-alanine", "d": [], "t": []}, {"i": "EC:4.1.1.64", "l": "\"2,2-dialkylglycine decarboxylase (pyruvate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190258", "l": "FGFR2c binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14695", "l": "a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP => a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761843", "l": "NFE2L2-dependent GSR gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69835", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77311", "l": "glyoxylate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211247", "l": "Cleavage of DNA by DFF40 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59869", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine => 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24797", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O = (S)-2-amino-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74903", "l": "(2E)-2-butenoate + ATP + H(+) = (2E)-but-2-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36762", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70845", "l": "L-arginine(out) + L-methionine(in) + Na(+)(in) => L-arginine(in) + L-methionine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102432", "l": "quercetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = rhamnetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013021", "l": "GDIs block activation of RHOB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66811", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH <=> 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004436", "l": "phosphatidylinositol diacylglycerol-lyase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052747", "l": "sinapyl alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944225", "l": "Association of procollagen type XVII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37618", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65526", "l": "9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794346", "l": "NRXNs bind NLGNs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44773", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23068", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA = 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.94", "l": "\"6-deoxyerythronolide-B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67543", "l": "(9Z)-hexadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21255", "l": "(S)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30665", "l": "hapalindole H => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49757", "l": "H(+) + O2 + protoviolaceinate => CO2 + H2O + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12809", "l": "4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": [], "t": []}, {"i": "EC:1.1.3.14", "l": "\"catechol oxidase (dimerizing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692880", "l": "HRH3 binds Hist (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55338", "l": "a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52174", "l": "11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781941", "l": "WNTs are secreted in exosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25660", "l": "(R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247839", "l": "Retromer associates with WLS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873923", "l": "STARD10 binds LPCAT1 and PC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592238", "l": "Expression of ALAS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23999", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036191", "l": "indolin-2-one monooxygenase activity", "d": ["Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008738", "l": "L-fuculose-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31729", "l": "(2S)-2-phenyloxirane + FAD + H(+) + H2O => FADH2 + O2 + styrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196017", "l": "Dynamin is recruited to the gap junction plaque (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41200", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69347", "l": "(E)-but-1-en-1-SO-peroxol <=> (Z)-butanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086090", "l": "voltage-gated potassium channel activity involved in SA node cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944215", "l": "Association of procollagen type XX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60740", "l": "(S)-(-)-citronellal + H2O + NADP(+) = (S)-(-)-citronellate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63761", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0018030", "l": "peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16023", "l": "enol-oxaloacetate => oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55454", "l": "daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19585", "l": "lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.52", "l": "\"3alpha-hydroxycholanate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353226", "l": "Association of Ku heterodimer with ends of DNA double-strand breaks (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77202", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxy-5-cholenate <=> 3beta-sulfo-5-cholenate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60808", "l": "gibberellin A19 + H(+) + O2 = CO2 + gibberellin A20 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39705", "l": "(13Z)-eicosenoyl-CoA + NADP(+) => (2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59870", "l": "4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+) => 4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694389", "l": "nsp3 is glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42676", "l": "L-cysteine + L-histidine + O2 = H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": [], "t": []}, {"i": "EC:1.14.99.52", "l": "\"L-cysteinyl-L-histidinylsulfoxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17860", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76074", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) <=> (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043792", "l": "enamidase activity", "d": ["Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12232", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.21.4.2", "l": "\"glycine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40893", "l": "H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102035", "l": "2-methylpropanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylpropanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67308", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990471", "l": "piRNA uni-strand cluster binding", "d": ["Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49529", "l": "(ethylene terephthalate)(n) + H2O => (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65706", "l": "alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34445", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874080", "l": "SRC phosphorylates PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69152", "l": "Removal of remaining Flap (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848110", "l": "SOCS3 binds activated PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032145", "l": "succinate-semialdehyde dehydrogenase binding", "d": ["Binding to succinate-semialdehyde dehydrogenase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51222", "l": "2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72124", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) => Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59206", "l": "AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+) => docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65963", "l": "ATP + H2O + leukotriene C4(out) <=> ADP + H(+) + leukotriene C4(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40182", "l": "decanoyl-CoA + O2 <=> (2E)-decenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9737780", "l": "MTTP binds lomitapide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10346", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192123", "l": "CYP27A1 27-hydroxylates CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30586", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide <=> 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.283", "l": "\"2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72722", "l": "eIF2 activation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417896", "l": "P2Y6 receptor can bind to UDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099507", "l": "ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "d": ["Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717841", "l": "holo-FDPS dimer binds NBPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58140", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) = AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71857", "l": "taurochenodeoxycholate(in) => taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877281", "l": "PIAS1 binds p-STAT1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46339", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O <=> 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65259", "l": "AH2 + O2 + verruculide C <=> A + H2O + verruculide C epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17212", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O <=> 2-formylglutarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806405", "l": "TP53 stimulates PMS2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033732", "l": "pyrroloquinoline-quinone synthase activity", "d": ["Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098608", "l": "methylselenol demethylase activity", "d": ["Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH."], "t": []}, {"i": "REACT:R-HSA-2408530", "l": "MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35462", "l": "cholesterol + NAD(+) <=> cholest-5-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12936", "l": "L-fuculose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24302", "l": "2 cob(II)yrinate a,c diamide + FMNH2 => 2 cob(I)yrinate a,c diamide + FMN + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044023", "l": "histone H4S1 kinase activity", "d": ["Catalysis of the reaction: histone H4-serine (position 1) + ATP = histone H4-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H4."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11935", "l": "2-hydroxy-2-methylpropanenitrile <=> acetone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15724", "l": "glycine + H2O + NAD(+) <=> glyoxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12827", "l": "[thioredoxin]-dithiol + H(+) + phosphate + sarcosine => [thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944242", "l": "Association of procollagen type XXVII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65927", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11992", "l": "L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": [], "t": []}, {"i": "EC:1.5.3.7", "l": "\"L-pipecolate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24395", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate <=> dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53190", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676595", "l": "TRAFs bind RANK:RANKL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32345", "l": "(+)-thujan-3-one + H(+) + NADH => (+)-thujan-3-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31713", "l": "11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65353", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25111", "l": "ATP + pyridoxine <=> ADP + H(+) + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18023", "l": "a ganglioside GD1a (d18:1(4E)) + CMP + H(+) => a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61687", "l": "glycero-2-phosphocholine + H2O <=> glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018796", "l": "4,5-dihydroxyphthalate decarboxylase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56701", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46021", "l": "[pyruvate, water dikinase] + ADP => [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240787", "l": "E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799350", "l": "Exocytosis of specific granule membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57318", "l": "ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+) => ATP + cytidine 5'-diphosphoramidate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008998", "l": "ribonucleoside-triphosphate reductase activity", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50308", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63444", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77094", "l": "Formation of cap binding complex (CBC) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015503", "l": "glutathione-regulated potassium exporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174963", "l": "NAT1 acetylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622310", "l": "Activated NOD1 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25528", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.86", "l": "\"phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30647", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.74", "l": "\"1L-myo-inositol 1-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797100", "l": "CCNK binds CDK13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61715", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine <=> 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75566", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25417", "l": "AH2 + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11074", "l": "catechol + CO2 + NADP(+) + NH4(+) => anthranilate + 3 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43403", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54489", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42205", "l": "corticosterone + NAD(+) => 11-dehydrocorticosterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68642", "l": "diphosphate + limonene => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33865", "l": "fumarate + menaquinol-7 => menaquinone-7 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62550", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.171", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73620", "l": "CTP(out) + GTP(in) => CTP(in) + GTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47241", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64948", "l": "dCTP + H2O = dCDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25209", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39244", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032323", "l": "oxo-DPAn-3s translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76999", "l": "H(+) + NAD(+) + reduced [4Fe-4S]/[3Fe-4S]-[ferredoxin] = NADH + oxidized [4Fe-4S]/[3Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15736", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O <=> (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047106", "l": "4-hydroxyphenylacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35490", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047222", "l": "mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229152", "l": "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018747", "l": "phenanthrene-1,2-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12191", "l": "2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] <=> CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322429", "l": "XIAP monoubiquinates TLE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72555", "l": "estrone 3-sulfate(out) + propanoate(in) = estrone 3-sulfate(in) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13989", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": [], "t": []}, {"i": "EC:2.7.7.12", "l": "\"UDP-glucose--hexose-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23077", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) => 2,4-dichlorobenzoyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76237", "l": "a tRNA with a 3' CCACCA end + 3 diphosphate => a tRNA with a 3' CCA end + ATP + 2 CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422454", "l": "Polysialylation of NCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52926", "l": "16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0015216", "l": "purine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008938", "l": "nicotinate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624985", "l": "CAV1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672969", "l": "Phosphorylation of RAF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68604", "l": "(2S)-3-sulfopropanediol = H(+) + hydroxyacetone + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.41", "l": "\"(2S)-3-sulfopropanediol sulfolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11957", "l": "cholesteryl 3-beta-D-glucoside + H2O => cholesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381109", "l": "IRE1 binds IRE1 forming dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047818", "l": "D-fuconate dehydratase activity", "d": ["Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57056", "l": "D-apiofuranose + NAD(+) = D-apionolactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.420", "l": "\"D-apiose dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66368", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA = 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36127", "l": "gibberellin A34 + S-adenosyl-L-methionine = O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36556", "l": "eicosanoyl-CoA + sphinganine => CoA + H(+) + N-eicosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48414", "l": "a globoside Gb4Cer + N-acetyl-alpha-D-galactosamine => a globoside IV3GalNAc-Gb4Cer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29259", "l": "(2R,3R)-tartrate(out) + succinate(in) = (2R,3R)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56070", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.71", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63811", "l": "ATP + citrate + spermidine <=> AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15373", "l": "columbamine + S-adenosyl-L-methionine = H(+) + palmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.118", "l": "\"columbamine O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67910", "l": "a primary alcohol + H(+) + sulfate => a primary linear alkyl sulfate ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669250", "l": "PAK1 phosphorylates FLNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5622134", "l": "CRABP1 binds atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53160", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine = an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.103", "l": "\"physarolisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672817", "l": "Active MTORC1 binds the ULK1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20226", "l": "(E)-caffeate + S-adenosyl-L-methionine => (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801195", "l": "STEAP3 binds BNIP3L (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75809", "l": "Na(+)(in) + propanoate(in) => Na(+)(out) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13400", "l": "6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + hexanedioate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59977", "l": "2-phenylacetate + H(+) => CO2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51631", "l": "formate + H(+) + UTP <=> CO2 + dUTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419011", "l": "Transhomodimerization of Nectins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028583", "l": "Phosphorylation of YAP by LATS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48114", "l": "H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019143", "l": "3-deoxy-manno-octulosonate-8-phosphatase activity", "d": ["Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976726", "l": "NOTCH2 coactivator complex binds HES5 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33705", "l": "CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine => (4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021609", "l": "ESR-associated SRC autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45252", "l": "tetradecanoate(out) = tetradecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19079", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22929", "l": "4-acetamidobutanoyl-CoA + H2O => 4-aminobutanoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54644", "l": "trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.172", "l": "\"trans-4-hydroxy-L-proline dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18738", "l": "ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420274", "l": "GIP receptor binds gastric inhibitory peptide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73107", "l": "acacetin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175117", "l": "1-LTR circle formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64331", "l": "(7Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (7Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623558", "l": "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42256", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810643", "l": "EPPIN protein complex binds bacteria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54098", "l": "H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45729", "l": "(E)-caffeyl alcohol + NADP(+) => (E)-caffeyl aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140707", "l": "chromatin-nuclear membrane anchor activity", "d": ["Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77474", "l": "hydrogen cyanide + pentan-2-one <=> (2S)-2-hydroxy-2-methylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018816", "l": "2-hydroxyisobutyrate dehydratase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050617", "l": "15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681980", "l": "ATG12 binds ATG7 dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877369", "l": "RUNX1 and FOXP3 bind the IFNG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444476", "l": "FPRL2 receptor binds a wide range of ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014456", "l": "GDIs block activation of RHOG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18566", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine => 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46165", "l": "a quinone + H(+) + NADPH => a quinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112333", "l": "SRC autophosphorylation is positively regulated by InlA-bound CDH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57992", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49006", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12643", "l": "3-phosphooxypyruvate + H(+) + NADH => (2R)-3-phosphoglycerate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132074", "l": "Cleavage of surface-bound factor B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42232", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66685", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] => L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69774", "l": "a short-chain fatty aldehyde + H2O + NAD(+) <=> a short-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75081", "l": "Formation of AT-AC B Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57263", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP <=> GDP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373087", "l": "Receptor CCR6 binds CCL20 ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10067", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097263", "l": "eoxin E4 synthase activity", "d": ["Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine."], "t": []}, {"i": "REACT:R-HSA-2161868", "l": "EXD4 is converted to EXE4 by DPEP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042929", "l": "ferrichrome transmembrane transporter activity", "d": ["Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034321", "l": "alcohol O-octanoyltransferase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388808", "l": "CD28 homodimer binds B7-2 monomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19261", "l": "ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.5", "l": "\"ABC-type heme transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28296", "l": "(-)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047218", "l": "hydroxycinnamate 4-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24861", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30887", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin = 7,8-dihydropteroate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11639", "l": "NADP(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21535", "l": "ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19233", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:3.1.2.22", "l": "\"palmitoyl-protein hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14511", "l": "3-epihydroxymugineate + CO2 + H(+) + succinate => 2-oxoglutarate + mugineate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195304", "l": "Association of beta-catenin with the destruction complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11290", "l": "H2O2 + macarpine => dihydromacarpine + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032770", "l": "Translocation of YAP1 to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24827", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388605", "l": "POMC(138-176) binds MC2R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656070", "l": "FGFBPs bind FGFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140407", "l": "L-alanine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74729", "l": "5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+) => acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679205", "l": "ULK1 phosphorylates Beclin-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41391", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30464", "l": "(2Z,6Z)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71164", "l": "homogentisate + O2 => maleylacetoacetate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63975", "l": "A + dihydropyriculol <=> AH2 + pyriculol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12090", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68506", "l": "(Z)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39643", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH = (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391939", "l": "TP receptor can bind thromboxane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74019", "l": "glycine(out) + L-alanine(in) = glycine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174097", "l": "Association of Emi1 with Cdh1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203977", "l": "SAR1 Activation And Membrane Binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77217", "l": "2-deoxyribose 5-triphosphate + adenine => dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12727", "l": "H(+) + keto-D-sorbose + NADH => D-iditol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943279", "l": "GGT dimers hydrolyse GSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73263", "l": "genkwanin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17628", "l": "D-lysopine + H2O + NADP(+) <=> H(+) + L-lysine + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174203", "l": "SCF-mediated degradation of Emi1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12239", "l": "H2O + NADP(+) + nicotinate <=> 6-hydroxynicotinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45420", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18061", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}, {"i": "EC:2.3.1.101", "l": "\"formylmethanofuran--tetrahydromethanopterin N-formyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76695", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047334", "l": "diphosphate-fructose-6-phosphate 1-phosphotransferase activity", "d": ["Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27351", "l": "arseno-mycothiol + H2O => arsenate + mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47802", "l": "an aromatic oxo-acid + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36069", "l": "Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine => Co-precorrin-6B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18245", "l": "3'-dephospho-CoA + ATP = ADP + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.24", "l": "\"dephospho-CoA kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997237", "l": "SH2B proteins bind JAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809254", "l": "MTMR8 binds MTMR9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446391", "l": "Formation of the PINCH-ILK-parvin complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53093", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358789", "l": "Self-ubiquitination of RNF41 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39538", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793451", "l": "MLKL binds ITCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26391", "l": "all-trans-10'-apo-beta-carotenal + beta-ionone => all-trans-beta-carotene + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15624", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.73", "l": "\"jararhagin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950342", "l": "EBI3:CANX binds IL27 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786650", "l": "DDHD1,2 hydrolyse PA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59364", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33064", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] => NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15222", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76846", "l": "H2O + NAD(+) + octylamine <=> H(+) + NADH + NH4(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853762", "l": "RET dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39617", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41471", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20893", "l": "butanoyl-CoA + phosphate => butanoyl phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62436", "l": "L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.176", "l": "\"L-lyxonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15752", "l": "(S)-mandelate + A <=> AH2 + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.62", "l": "\"subtilisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51094", "l": "10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35777", "l": "2-oxoglutaramate + UDP-alpha-D-kanosamine => L-glutamine + UDP-3-oxo-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44853", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046421", "l": "methylisocitrate lyase activity", "d": ["Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32928", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58513", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25826", "l": "H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + O2 + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57147", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75342", "l": "chloride(out) + nitrate(in) <=> chloride(in) + nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938231", "l": "RUNX1:CBFB binds CREBBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168885", "l": "Haptoglobin binds Hemoglobin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669900", "l": "KIT mutants bind type II TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22577", "l": "an N-acyl-L-homoserine lactone + H2O => an N-acyl-L-homoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140625", "l": "opioid growth factor receptor activity", "d": ["Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76476", "l": "hexadecan-1-ol + O2 => H2O2 + hexadecanal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67549", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O => [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964274", "l": "G alpha (12) binds BTK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23386", "l": "beta-D-glucosyl-(1->4)-D-mannopyranose => D-cellobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45571", "l": "[heparosan](n) <=> [acharan](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73251", "l": "cirsimaritin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862700", "l": "CMKLR1 binds Resolvin E1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28179", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => colnelenate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030599", "l": "pectinesterase activity", "d": ["Catalysis of the reaction: pectin + n H2O = n methanol + pectate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390597", "l": "Release Of ADP From Myosin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29509", "l": "(-)-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32183", "l": "cholesterol + O2 = cholest-5-en-3-one + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.6", "l": "\"cholesterol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38392", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50675", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35000", "l": "ADP(in) + ATP(out) => ADP(out) + ATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16513", "l": "(S)-lactate + O2 = acetate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.13.12.4", "l": "\"lactate 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787566", "l": "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19586", "l": "lithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16191", "l": "CO2 + homogentisate => 3-(4-hydroxyphenyl)pyruvate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48257", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391933", "l": "EP3 receptor can bind PGE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11658", "l": "AMP + diphosphate + L-prolyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678517", "l": "Defective ABCB11 does not transport bile salts from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170003", "l": "heme B transmembrane transporter activity", "d": ["Enables the transfer of heme B from one side of a membrane to the other."], "t": []}, {"i": "RHEA:75443", "l": "heme b(in) = heme b(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710101", "l": "CASP4, CASP5 cleave GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55029", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine => an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61580", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) = (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451463", "l": "pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018775", "l": "2-hydroxymuconate-semialdehyde hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60414", "l": "[N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+) => H2O + monoglucosyl-enterobactin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14699", "l": "(2E,6E)-farnesal + H(+) + NADPH => (2E,6E)-farnesol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871260", "l": "YAP1 binds TEAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76368", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34074", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20632", "l": "H2O + O-phospho-L-seryl-[protein] <=> L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935960", "l": "RUNX1 binds the TJP1 (ZO-1) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65890", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27473", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.167", "l": "\"D-glycero-beta-D-manno-heptose-7-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49085", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] => (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45242", "l": "a (2E,4E)-(5,6-saturated)-dienoyl-CoA => a (3E,5Z)-dienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49058", "l": "asperlicin E + H2O + NADP(+) => asperlicin C + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33406", "l": "ATP + L-threonine <=> diphosphate + L-threonyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49350", "l": "2-oxospirilloxanthin + H2O => 2,2-dihydroxyspirilloxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16366", "l": "digallate + H2O => 2 3,4,5-trihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874186", "l": "MBTPS1 (S1P) cleaves CREB3L4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964912", "l": "DHAP from Ery4P and PEP (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209924", "l": "Dopa is decarboxylated to dopamine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24157", "l": "2-methylpropanoate + ATP => 2-methylpropanoyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693609", "l": "ATM phosphorylates TP53 at S15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317332", "l": "PIP3 recruits AKT to the membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45322", "l": "H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine => H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985943", "l": "p-Y701-STAT1 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13290", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022873", "l": "protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72355", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658430", "l": "NF1 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19263", "l": "ADP + H(+) + heme b(out) + phosphate => ATP + H2O + heme b(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016251", "l": "RNA polymerase II general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35854", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114671", "l": "vWF binds to collagen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37796", "l": "2 H(+) + 2 NADPH + O2 => 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50839", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010428", "l": "methyl-CpNpG binding", "d": ["Binding to a methylated cytosine/unspecified/guanine trinucleotide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27412", "l": "3 a menaquinone + protoporphyrinogen IX <=> 3 a menaquinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047872", "l": "dolichol O-acyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615249", "l": "ARBs bind AGRT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20848", "l": "H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.3", "l": "\"pyruvate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24099", "l": "isoorientin + S-adenosyl-L-methionine <=> H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788061", "l": "Fibronectin degradation by ADAM8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140741", "l": "WNT5A binds FZD and ROR receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937419", "l": "CBR3 reduces DOX to DOXOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31050", "l": "(S)-2-methyl-3-oxopropanoate + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42448", "l": "(R)-2-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.167", "l": "\"(R)-2-hydroxyglutaryl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43083", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202222", "l": "Phosphorylation of PKC theta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44875", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033829", "l": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51623", "l": "CTP + formate + H(+) <=> CO2 + dCTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27989", "l": "hydroxyacetone + NADP(+) <=> H(+) + methylglyoxal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48167", "l": "epoxypheophorbide a + H2O <=> H(+) + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25924", "l": "A + H2O + quinolin-8-ol = 8-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264458", "l": "Proteasome mediated degradation of COP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002460", "l": "P4HB binds Collagen chains (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36439", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27353", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine = H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.164", "l": "\"demethylrebeccamycin-D-glucose O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73988", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + discoidol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11196", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": [], "t": []}, {"i": "EC:2.4.2.21", "l": "\"nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72818", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.158", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28222", "l": "3-dehydro-L-gulonate + ATP = 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14439", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928641", "l": "PAK binds RAC and bPIX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008495", "l": "protoheme IX farnesyltransferase activity", "d": ["Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75256", "l": "mangiferin + O2 => 3'-dehydromangiferin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632182", "l": "PRMT1 methylates ESRs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68570", "l": "(3S)-1,2-diazinane-3-carboxylate + H(+) + H2O => N(5)-hydroxy-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730835", "l": "Autophosphorylation of PKC-theta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25649", "l": "(2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.82", "l": "\"(-)-isopiperitenone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.20", "l": "\"ribonuclease U2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340226", "l": "CYGB dioxygenates NO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71616", "l": "(S)-malate(in) + sulfate(out) => (S)-malate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009817", "l": "Acitretin binds to RAR:RXR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47124", "l": "glycine + hexacosanoate = H2O + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52979", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374909", "l": "Catabolism of Noradrenaline (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433418", "l": "Phosphorylation of JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047735", "l": "cellobiose dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416562", "l": "p190RhoGAP binds Plexin-B1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61783", "l": "keto-L-tagatose <=> keto-L-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139941", "l": "Binding of IP3 to IP3 receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050404", "l": "zeatin O-beta-D-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48309", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O => (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52749", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O => 2 isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53567", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647594", "l": "SAHF formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42727", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10887", "l": "(24R,24(1)R)-fucosterol epoxide <=> acetaldehyde + desmosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18696", "l": "a penicillin + H2O <=> 6-aminopenicillanate + a carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56330", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683546", "l": "FURIN binds furin inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41156", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674385", "l": "p-T,Y MAPKs dimerize (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83650", "l": "FasL:Fas binds FADD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937613", "l": "CRHBP binds CRH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71731", "l": "citrate(out) + tartrate(in) = citrate(in) + tartrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50359", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 <=> 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72649", "l": "1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+) => 1,6-dihydroxyphenazine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65733", "l": "2-oxoglutarate + heptyl sulfate + O2 => CO2 + H(+) + heptanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41332", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358619", "l": "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54471", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68106", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone => all-trans-zeaxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004698", "l": "calcium,diacylglycerol-dependent serine/threonine kinase activity", "d": ["Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72338", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate <=> 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787737", "l": "CSF3R binds CSF3 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26128", "l": "(+)-copalyl diphosphate = diphosphate + isopimara-7,15-diene", "d": [], "t": []}, {"i": "EC:4.2.3.44", "l": "\"isopimara-7,15-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229283", "l": "LCNs bind lipids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696357", "l": "LAIR2 binds collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10790", "l": "6-phospho-2-dehydro-D-gluconate + ADP + H(+) => 2-dehydro-D-gluconate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451474", "l": "Bacterial Flagellin binds TLR5 homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805479", "l": "TP53RK phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20866", "l": "beta-D-glucose 1-phosphate + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51951", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60749", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202731", "l": "JAM3 dimerises (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66766", "l": "ADP + folate(out) + H(+) + phosphate => ATP + folate(in) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24987", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58317", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545253", "l": "Deacetylation of cohesin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66005", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62303", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.49", "l": "\"omptin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61513", "l": "malvidin + UDP-alpha-D-glucose => malvidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047154", "l": "methylmalonyl-CoA carboxytransferase activity", "d": ["Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030792", "l": "methylarsonite methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0061791", "l": "GTPase motor activity", "d": ["A motor activity driven by GTP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41867", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH <=> decanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202947", "l": "Caspase mediated cleavage of APC (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48350", "l": "a pseudouridine in RNA => a uridine in RNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934446", "l": "Activated PKC phosphorylates SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36139", "l": "(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10998", "l": "2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine => 2-methylpropanal oxime + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56997", "l": "aldehydo-D-apiose => apulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428260", "l": "DEGS2 oxygenates dihydroceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51823", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) <=> AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008663", "l": "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194800", "l": "botE LC cleaves target cell SNAP25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62653", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218836", "l": "PTK2beta binds alphaVbeta3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75847", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264848", "l": "apoA-I binds to CUBN:AMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445705", "l": "Release Of ADP From Myosin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32861", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70246", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose <=> a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70832", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) => L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42302", "l": "a 1-acyl-sn-glycero-3-phosphate + holo-[ACP] => a fatty acyl-[ACP] + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757256", "l": "MCM3 binds MCM5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56757", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16065", "l": "2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.18", "l": "\"phytanoyl-CoA dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68878", "l": "AMP + diphosphate + NADP(+) + piperonal => ATP + H(+) + NADPH + piperonylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26495", "l": "chloride + FADH2 + L-tryptophan + O2 => 7-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24009", "l": "ATP + hypotaurocyamine => ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41076", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51681", "l": "(2E,6E)-farnesol + CTP => (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.6", "l": "\"nucleoside deoxyribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11037", "l": "a quaternary ammonium(out) + ATP + H2O => a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36024", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57656", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1balpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43030", "l": "2-aminoprop-2-enoate + H(+) + sulfite => L-cysteate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59380", "l": "4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.121", "l": "\"4-amino-4-deoxyprephenate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21912", "l": "CoA + H(+) + O2 + pyruvate = acetyl-CoA + CO2 + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.6", "l": "\"pyruvate oxidase (CoA-acetylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73628", "l": "CTP(out) + GMP(in) => CTP(in) + GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201515", "l": "Active ALK recruits PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65076", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51751", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A <=> 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864577", "l": "TFAP2C translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987007", "l": "p-STAT1 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035496", "l": "lipopolysaccharide-1,5-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66487", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose <=> 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670014", "l": "Factor VIIIa dissociates  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000402", "l": "crossed form four-way junction DNA binding", "d": ["Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17677", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.66", "l": "\"2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704297", "l": "CHRM2 binds CHRM2 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191654", "l": "c-src associates with Cx43 in gap junctions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27765", "l": "CTP + H2O <=> CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018025", "l": "calmodulin-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678925", "l": "NR3C1 binds NR3C1 agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61847", "l": "solasodine + UDP-alpha-D-glucose <=> H(+) + solasodine 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65375", "l": "a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate <=> a globoside MSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033428", "l": "CAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58234", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein] => L-seryl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52007", "l": "H2O + methylglyoxal + NAD(+) <=> 2 H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42530", "l": "pseudouridine(955/2504/2580) in 23S rRNA => uridine(955/2504/2580) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432411", "l": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706312", "l": "Active FLT3 binds to LCK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14349", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.37", "l": "\"fucosylgalactoside 3-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421835", "l": "trans-Golgi Network Vesicle Scission (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40666", "l": "L-serine <=> 2-aminoprop-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810392", "l": "TMEM55B translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51507", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose <=> a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59774", "l": "D-sorbopyranose + H2O2 => D-sorbitol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395768", "l": "LPL hydrolyses TGs from mature CMs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34197", "l": "2 aureusidin 6-O-beta-glucoside + 2 H2O => 2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814409", "l": "CK2 phosphorylates PDCL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25237", "l": "ATP + CDP = ADP + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32398", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63185", "l": "NADH + 2 O2 => H(+) + NAD(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50732", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55413", "l": "[phosphate](n) + GTP => [phosphate](n+1) + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944214", "l": "Association of procollagen type I (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39266", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH <=> (13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713785", "l": "Anti-cancer drugs generate DNA interstrand crosslinks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687458", "l": "HSV1 RIR1 binds CASP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679266", "l": "Beclin-1 complex translocates to the ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53075", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44172", "l": "H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64855", "l": "benzoyl-CoA + octan-1-ol <=> CoA + octyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183126", "l": "Factor B binds to surface-associated C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198508", "l": "MDH1 oxidizes MAL to OA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27497", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine = 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35514", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004900", "l": "erythropoietin receptor activity", "d": ["Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408529", "l": "Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21474", "l": "(3S)-citryl-CoA + ADP + phosphate => ATP + citrate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47192", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] = Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163672", "l": "Phosphorylation of ChREBP at Thr(653) by PKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76924", "l": "2-methylcyclopentanamine + H2O + NADP(+) => 2-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74167", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] = formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140844", "l": "NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-2 residue of the N-terminal tail of histone H2B (or an equivalent residue)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56151", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine <=> CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050231", "l": "putrescine carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578717", "l": "BCDIN3D dimethylates 5' phosphate of pre-miR-145 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976563", "l": "NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13556", "l": "alpha-D-galactose + ATP <=> ADP + alpha-D-galactose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39853", "l": "a 1,2-diacyl-sn-glycerol + glycerol => 2 a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23611", "l": "H(+) + H2O + N-isopropylammelide <=> cyanurate + isopropylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228992", "l": "ROCK1,ROCK2 are activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13056", "l": "L-phenylalanine + pyruvate <=> 3-phenylpyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67154", "l": "L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17086", "l": "4-pyridoxate + A => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983138", "l": "Transport of MHC heterotrimer to ER exit site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.153640326263854", "identifiers": [{"i": "GO:0003690", "l": "double-stranded DNA binding", "d": ["Binding to double-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662613", "l": "MT3 exchanges zinc for copper (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68588", "l": "(6R)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine = (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": [], "t": []}, {"i": "EC:2.1.2.14", "l": "\"GDP-perosamine N-formyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46036", "l": "2'-deoxycytidine + UTP = dCMP + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23669", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin => AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033827", "l": "high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617828", "l": "TRIP11:IFT20 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73077", "l": "H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170704", "l": "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42688", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.4.1.36", "l": "\"hercynylcysteine S-oxide lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19784", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802908", "l": "RAS mutants bind inactive RAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65752", "l": "2-oxoglutarate + L-glutamate + O2 = (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.76", "l": "\"L-glutamate 3(R)-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46005", "l": "2-methylpropanal + CoA + NAD(+) => 2-methylpropanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48277", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73524", "l": "TTP(out) + UTP(in) => TTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54407", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429529", "l": "Thrombin binding to GP1b:IX:V (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59686", "l": "D-maltohexaono-1,5-lactone + H2O2 => D-maltohexaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68174", "l": "CO2 + H2O + isodomoate A + succinate => 2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047593", "l": "6-acetylglucose deacetylase activity", "d": ["Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193656", "l": "p75NTR interacts with RIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57254", "l": "glycolate + GTP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102500", "l": "beta-maltose 4-alpha-glucanotransferase activity", "d": ["Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33273", "l": "a 1,2-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0008477", "l": "purine nucleosidase activity", "d": ["Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004703", "l": "G protein-coupled receptor kinase activity", "d": ["Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75214", "l": "Cu(+)(out) <=> Cu(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12308", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) = 2 H(+) + L-2-aminoadipate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23236", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.61", "l": "\"protein-glutamate methylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42962", "l": "NADH + 2 oxidized [nitric oxide reductase rubredoxin domain] => H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34089", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47800", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13696", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64903", "l": "H2O + UTP <=> H(+) + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19996", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64222", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38506", "l": "a 1,3-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694794", "l": "mRNA3 is translated to protein 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58233", "l": "L-seryl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69973", "l": "(22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102325", "l": "2,2',3-trihydroxybiphenyl monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ = 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017020", "l": "myosin phosphatase regulator activity", "d": ["Binds to and modulates of the activity of myosin phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692755", "l": "CDK1 phosphorylates MAPK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22302", "l": "a flavonol 3-O-beta-D-glucoside + H(+) + UDP => a flavonol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23533", "l": "ATP + cholate + CoA => AMP + choloyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55645", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] => ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20889", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51721", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77068", "l": "Activation of GT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210289", "l": "Recruitment of SYK to p-DAP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23623", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine <=> AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69811", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59335", "l": "1'-hydroxy-gamma-carotene + A <=> 1'-hydroxytorulene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950173", "l": "Expression of ADP-ribosylation factor 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71362", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106054", "l": "tRNA-uracil-34 sulfurtransferase activity", "d": ["Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34064", "l": "2-deoxystreptamine + UDP-alpha-D-glucose => 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77205", "l": "3alpha-sulfodeoxycholate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46367", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400143", "l": "Fatty acid ligands activate PPARA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30045", "l": "iminosuccinate + succinate => fumarate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296045", "l": "Activation of Potassium transport channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18974", "l": "2-oxoglutarate + deacetoxyvindoline + O2 => 4-O-deacetylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55024", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12285", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016492", "l": "G protein-coupled neurotensin receptor activity", "d": ["Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41619", "l": "D-ribose 2,5-bisphosphate + H2O <=> D-ribose 5-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209910", "l": "Iodide is taken up by thyroid epithelial cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61777", "l": "rebaudioside D + UDP-alpha-D-glucose => H(+) + rebaudioside M + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607737", "l": "BCL10 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.112", "l": "\"indanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730899", "l": "Oligomerization of BCL10 and MALT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46046", "l": "(2E)-octenoyl-CoA => (3Z)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190065", "l": "Activated TrkA receptor internalizes to endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169895", "l": "Crk's SH3 domain engages C3G (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29872", "l": "ATP + H2O + thiosulfate(out) => ADP + H(+) + phosphate + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668395", "l": "CHMP7 binds CC2D1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60633", "l": "all-trans-4-oxoretinol + NAD(+) => all-trans-4-oxoretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.1", "l": "\"triphosphate--protein phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34443", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.210", "l": "\"dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53886", "l": "alpha,alpha-trehalose 6-phosphate + CDP + H(+) => CDP-alpha-D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191830", "l": "snRNP nuclear import and release (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75863", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24611", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) <=> 2,5-dioxopentanoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65334", "l": "chrodrimanin E + H2O + NADP(+) => H(+) + NADPH + O2 + verruculide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102136", "l": "3-epi-6-deoxocathasterone C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reducdtase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65780", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53203", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23591", "l": "oxalate + succinyl-CoA <=> oxalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0031685", "l": "adenosine receptor binding", "d": ["Binding to an adenosine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71939", "l": "2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10124", "l": "H(+) + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.92", "l": "\"phenylacetone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37660", "l": "anthraniloyl-CoA + methanol => CoA + O-methyl anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008411", "l": "4-hydroxybutyrate CoA-transferase activity", "d": ["Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9620103", "l": "ALDH2 transforms GTN to NO (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008756", "l": "o-succinylbenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44086", "l": "AMP + diphosphate + heptadecanoyl-CoA => ATP + CoA + heptadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192061", "l": "CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839102", "l": "BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706399", "l": "RHOBTB3 hydrolyzes ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51685", "l": "(2E,6E)-farnesyl phosphate + CTP => (2E,6E)-farnesyl diphosphate + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72697", "l": "Start codon recognition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22321", "l": "2 alpha-D-glucose 1-phosphate + H2O => D-maltose + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62379", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O <=> (S)-lactate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190256", "l": "FGFR1c binds to FGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66854", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate => (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015527", "l": "glycerol-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24003", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] <=> a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.176141984063477", "identifiers": [{"i": "GO:0003924", "l": "GTPase activity", "d": ["Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52877", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782655", "l": "HDAC10 deacetylates histone (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67196", "l": "H2O + N-acetylserotonin = acetate + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60262", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48003", "l": "1,6-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834003", "l": "L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156682", "l": "PLK1 phosphorylates NUDC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54069", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + sesterfisherol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043824", "l": "succinylglutamate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H2O + NAD+ = N-succinyl-L-glutamate + 2 H+ + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867344", "l": "OMA1 hydrolyses OPA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358789", "l": "Self-ubiquitination of RNF41 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23549", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099619", "l": "UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333671", "l": "CLCAs self cleave (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44014", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177942", "l": "EGFR binds EGF ligand (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40289", "l": "AMP + decanedioyl-CoA + diphosphate => ATP + CoA + decanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40667", "l": "2-aminoprop-2-enoate = 2-iminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27918", "l": "H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53946", "l": "(2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH => 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44515", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28203", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64728", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10074", "l": "glycine betaine + H(+) + S-adenosyl-L-homocysteine => N,N-dimethylglycine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389862", "l": "Conversion of glyoxylate to oxalate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16102", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43460", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19749", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.183", "l": "\"alpha-1,3-glucan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36054", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O <=> 2 beta-L-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867344", "l": "OMA1 hydrolyses OPA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204871", "l": "Interaction of Tie2 and Grb2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395517", "l": "NADPH transfers electrons to FDXR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22170", "l": "UDP-alpha-D-galactose => UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25526", "l": "9alpha-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77032", "l": "(2R)-heptan-2-amine + H2O + NAD(+) => H(+) + heptan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23420", "l": "alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.12", "l": "\"trehalose-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53865", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676255", "l": "Formation of the MLL2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74172", "l": "an N-methyl carbamate ester + H(+) + H2O => an alcohol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624131", "l": "UNC119B binds myristoylated proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77088", "l": "isochorismoyl-L-glutamate => N-pyruvoyl-L-glutamate + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37108", "l": "H2O + N(7)-methyl-GMP => N(7)-methylguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76868", "l": "(R)-1-phenylethylamine + H2O + NAD(+) => acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170159", "l": "Translocation of Cdc25 to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31816", "l": "(2E,6E)-farnesyl diphosphate => (+)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42182", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23173", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49093", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69639", "l": "H2O + phlorizin = beta-D-glucose + phloretin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33354", "l": "hexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48705", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705926", "l": "AR binds AR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944454", "l": "mTORC1 phosphorylates MAF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704330", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483087", "l": "PI is exchanged with PC by PITPNB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61744", "l": "steviolbioside + UDP-alpha-D-glucose = stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102013", "l": "ATPase-coupled L-glutamate tranmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0004807", "l": "triose-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140332", "l": "lipopolysaccharide transfer activity", "d": ["Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75090", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74910", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] <=> (2E)-butenoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49207", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050588", "l": "apo-beta-carotenoid-14',13'-dioxygenase activity", "d": ["Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418091", "l": "F2R binds ARRB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22464", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48623", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18875", "l": "chloride + H(+) + NH4(+) + pyruvate => 3-chloro-D-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086037", "l": "P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76833", "l": "H(+) + hexanal + NADH + NH4(+) => H2O + hexylamine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31416", "l": "(2Z,6E)-farnesyl diphosphate => (+)-2-epi-prezizaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051269", "l": "alpha-keto ester reductase activity", "d": ["Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433451", "l": "JAK2 binds to p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32124", "l": "citrate(in) + H(+)(in) => citrate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71401", "l": "2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxusin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.32", "l": "\"17alpha-hydroxyprogesterone deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172666", "l": "RB1 binds condensin II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17949", "l": "3-hydroxy-1H-quinolin-4-one + O2 = CO + H(+) + N-formylanthranilate", "d": [], "t": []}, {"i": "EC:1.13.11.47", "l": "\"3-hydroxy-4-oxoquinoline 2,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665761", "l": "FMNL3 binds RHOC:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62362", "l": "(Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799097", "l": "ATM phosphorylates ZNF420 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37393", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64810", "l": "CoA + H(+) + O-(2-acetamidoethyl)-L-serine => acetyl-CoA + O-(2-aminoethyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20053", "l": "NAD(+) + ribitol = D-ribulose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.56", "l": "\"ribitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392834", "l": "Activation of EPACs by cAMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33641", "l": "AMP + diphosphate + tetracosanoyl-CoA => ATP + CoA + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034819", "l": "3-HSA hydroxylase activity", "d": ["Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63458", "l": "(2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+) => (2E,6E,10E)-geranylgeraniol + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68420", "l": "cis-(homo)3aconitate + H2O = (2R,3S)-iso(homo)3citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68280", "l": "L-seryl-[protein] + pentanoyl-CoA = CoA + O-pentanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33019", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA = (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.264", "l": "\"beta-lysine N(6)-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74590", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-exo-beta-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59352", "l": "beta-lactose + O2 = H2O2 + lactobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612501", "l": "SGK phosphorylates CREB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139899", "l": "Sequestration of BAD protein by 14-3-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35478", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051698", "l": "saccharopine oxidase activity", "d": ["Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9711058", "l": "SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018774", "l": "RHOBTB1 binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23908", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine = 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": [], "t": []}, {"i": "EC:1.16.1.8", "l": "\"[methionine synthase] reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34149", "l": "2-deoxy-scyllo-inosamine + 2-oxoglutaramate => 2-deoxy-L-scyllo-inosose + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29007", "l": "H(+)(in) + Mn(2+)(in) = H(+)(out) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59709", "l": "D-maltotriono-1,5-lactone + H2O => D-maltotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51648", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57908", "l": "ATP + L-glutamyl-tRNA(Gln) = 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102361", "l": "esculetin 4-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose = 4-O-beta-D-glucosyl-esculetin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672948", "l": "MARK3 phosphorylates KSR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62019", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69299", "l": "CDT1 binds geminin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607740", "l": "PKC-delta phosphorylates CARD9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67490", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74681", "l": "UDP-beta-L-arabinofuranose(out) + UMP(in) => UDP-beta-L-arabinofuranose(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76620", "l": "(6E)-8-methylnon-6-enoyl-CoA + 4-hydroxy-3-methoxy-benzenemethanol => capsiate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445448", "l": "HHIP binds Hedgehog (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18188", "l": "adenosine + O2 <=> 5'-dehydroadenosine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10218", "l": "ADP + H(+) + phospho-[DNA-directed RNA polymerase] => [DNA-directed RNA polymerase] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11645", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49057", "l": "asperlicin C + H(+) + NADPH + O2 => asperlicin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220979", "l": "NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419003", "l": "Interaction of Nectins with Afadin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58299", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996727", "l": "REST recruits the BHC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29230", "l": "H(+)(in) + indole(in) <=> H(+)(out) + indole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72427", "l": "chloride(in) + K(+)(in) = chloride(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048529", "l": "magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity", "d": ["Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102043", "l": "isopentenyl phosphate kinase activity", "d": ["Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) = isopentenyl diphosphate(3-) + ADP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186773", "l": "PDGF dimer binds two receptors simultaneously (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448591", "l": "Interleukin-32 binds proteinase-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694563", "l": "ABHD10 hydrolyses MPAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59193", "l": "ATP + eicosanoate + H(+) => diphosphate + icosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209313", "l": "Autocleavage of HH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22960", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.88", "l": "\"isoflavone 3'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26029", "l": "3-aminopropanal + H2O2 + N-acetylputrescine => H2O + N(1)-acetylspermidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686578", "l": "Activated ATM phosphorylates ABL1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140802", "l": "NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: [protein]-C-terminal glycine + NAD+ = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide."], "t": []}, {"i": "RHEA:58268", "l": "[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40436", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944246", "l": "Association of procollagen type XXI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67922", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351207", "l": "Spermine  => N-acetylated spermine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18552", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033767", "l": "4-hydroxyacetophenone monooxygenase activity", "d": ["Catalysis of the reaction: 4'-hydroxyacetophenone + H+ + NADPH + O2 = 4-hydroxyphenyl acetate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38265", "l": "2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44099", "l": "decan-1-ol + hexadecanoyl-CoA <=> CoA + decanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682712", "l": "nsp15 binds RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380586", "l": "loading of Serotonin in synaptic vesicles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52306", "l": "(2S)-2-acetamido-4-aminobutanoate => H2O + L-ectoine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59754", "l": "CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20892", "l": "butanoyl-CoA + phosphate = butanoyl phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.19", "l": "\"phosphate butyryltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53499", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59287", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O <=> D-glucose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879298", "l": "acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019144", "l": "ADP-sugar diphosphatase activity", "d": ["Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61882", "l": "1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69447", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64845", "l": "(2E)-geraniol + benzoyl-CoA => (2E)-geranyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15884", "l": "ATP + L-seryl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16118", "l": "acetoacetate + ATP + CoA => acetoacetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63592", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086078", "l": "gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204169", "l": "PDP dephosphorylates p-lipo-PDH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52867", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167924", "l": "SMAD7:SMURF1 complex binds XPO1 (CRM1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835385", "l": "DUS2 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045158", "l": "electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity", "d": ["Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660192", "l": "VDR agonists bind VDR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703440", "l": "FLT3 fusions:GRB2 bind GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25669", "l": "(2E)-geranyl diphosphate <=> beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74768", "l": "S-adenosyl-L-methionine + syringetin => 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202111", "l": "AKT1 phosphorylates eNOS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879362", "l": "AGER binds ERK1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76572", "l": "4-deoxy-L-erythro-hex-4-enopyranuronate => (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11948", "l": "4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.23", "l": "\"4-hydroxybenzoyl-CoA thioesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835252", "l": "Expression of PAX7 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50329", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37153", "l": "1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805276", "l": "CDK5 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37856", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA => 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48541", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34971", "l": "Fe(3+)(in) = Fe(3+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49308", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60746", "l": "CoA + pyrethrin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57313", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27456", "l": "iodide + L-tyrosine + NADP(+) <=> 3-iodo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140702", "l": "cyclic GMP-AMP binding", "d": ["Binding to cyclic GMP-AMP (cGAMP) nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.329", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46457", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008933", "l": "lytic transglycosylase activity", "d": ["Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39084", "l": "3-oxododecanedioyl-CoA + CoA => acetyl-CoA + decanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36229", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635927", "l": "ATF4 and a CEBP protein bind the TRIB3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014812", "l": "ROBOs bind keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36430", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391935", "l": "DP1 receptor can bind PGD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44715", "l": "a 1,2-diacylglycerol + H2O <=> a 1-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209754", "l": "Photolytic cleavage and thermal isomerization of 7-dehydroCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68094", "l": "a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+) => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163669", "l": "Transcriptional activation of pyruvate kinase gene by ChREBP:MLX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202137", "l": "AKT1 binds eNOS complex via HSP90 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47642", "l": "4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000034", "l": "adenine deaminase activity", "d": ["Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51757", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781953", "l": "YOD1 binds VCP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77121", "l": "1D-myo-inositol 1,2,6-trisphosphate + phosphate => 1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102326", "l": "2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O = 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64333", "l": "ATP + CoA + nicotinate => AMP + diphosphate + nicotinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052867", "l": "phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658253", "l": "RAS:GTP binds PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52057", "l": "12-hexadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64547", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24137", "l": "3'-phosphoadenylyl sulfate + a primary amine => a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5140741", "l": "WNT5A binds FZD and ROR receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40463", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20025", "l": "gibberellin A3 + UDP-alpha-D-glucose = gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.176", "l": "\"gibberellin beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46537", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16390", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 => CO2 + H2O + hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52303", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199404", "l": "CD40L binds CD40 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35643", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21625", "l": "FMNH2 + NADP(+) => FMN + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75165", "l": "H(+) + NADP(+) + UDP => NAD(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008822", "l": "PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49451", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O <=> alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483087", "l": "PI is exchanged with PC by PITPNB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59118", "l": "[protein]-disulfide + H2O2 => [protein]-dithiol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53139", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446077", "l": "BP230 interacts with keretin K5/K14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26548", "l": "beta-alanine + NH4(+) => beta-alaninamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37474", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66203", "l": "O2 + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75411", "l": "demethyllactenocin + S-adenosyl-L-methionine = H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30985", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103060", "l": "kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose = kaempferol-3-rhamnoside-7-rhamnoside + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15045", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63138", "l": "cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione => adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26290", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine => 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69234", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => (Z)-3-hydroxypropyl glucosinolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102084", "l": "L-dopa O-methyltransferase activity", "d": ["Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine = 3-O-methyldopa + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419861", "l": "Melanospin is stimulated by light (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614614", "l": "Cysteine is degraded to serine and H2S (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35374", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.10.1.-", "l": "\"Acting on sulfur-nitrogen bonds\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875531", "l": "MET binds TNS4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77025", "l": "2-oxoglutarate + H(+) + NADH + NH4(+) => D-glutamate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47961", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63611", "l": "apelin-17 + H2O <=> apelin-16 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821967", "l": "SRPK1 phosphorylates PRM2 in PRM2:dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74588", "l": "(2E,6E)-farnesyl diphosphate => (+)-exo-beta-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47562", "l": "a ganglioside GM1b (d18:1(4E)) + CMP + H(+) => a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615023", "l": "PLXNA4 gene expression is stimulated by FOXO6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51925", "l": "AH2 + menaquinone-9 => A + beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380216", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27379", "l": "(2R)-2-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.7", "l": "\"chaperonin ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63907", "l": "2 3-phenylpyruvate + H(+) <=> H2O + phenguignardate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173739", "l": "Spontaneous hydrolysis of C3 thioester (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102289", "l": "beta-amyrin 11-oxidase activity", "d": ["Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ = 11-oxo-beta-amyrin + 3 H2O + 2 NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28503", "l": "NAD(+) + S-(hydroxymethyl)mycothiol => H(+) + NADH + S-formylmycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001515", "l": "opioid peptide activity", "d": ["Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45143", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O <=> CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.121", "l": "\"colneleate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26559", "l": "(3S)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31708", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428625", "l": "Vesicular inhibitory amino acid transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18341", "l": "D-xylono-1,4-lactone + H2O = D-xylonate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.68", "l": "\"xylono-1,4-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679028", "l": "JAK3 binds JAK3 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64243", "l": "glycine + octanoyl-CoA <=> CoA + H(+) + N-octanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52766", "l": "(E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450975", "l": "isocitrate <=> citrate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72284", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58769", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24580", "l": "D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.50", "l": "\"sorbitol-6-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57408", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190260", "l": "FGFR2b binds to FGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68899", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH <=> 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24883", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032841", "l": "calcitonin binding", "d": ["Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35466", "l": "lathosterol + NAD(+) <=> 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691131", "l": "CANDI binds CUL1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14950", "l": "A + H2O + quinoline-4-carboxylate => 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420121", "l": "SFKs phosphorylate PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49208", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55732", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004445", "l": "inositol-polyphosphate 5-phosphatase activity", "d": ["Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65000", "l": "holo-[ACP] + octanoyl-AMP = AMP + H(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23542", "l": "AMP + diphosphate + L-glutamyl-tRNA(Glu) => ATP + L-glutamate + tRNA(Glu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201669", "l": "Beta-catenin translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62298", "l": "(+)-malbrancheamide + 2 FADH2 => (+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29271", "l": "a menaquinol + H(+) + trimethylamine N-oxide = a menaquinone + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16412", "l": "1,2-dihydrovomilenine + NADP(+) <=> H(+) + NADPH + vomilenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647746", "l": "EML4 trimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204798", "l": "Interaction of Tie2 and p85 of PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140344", "l": "triglyceride transfer activity", "d": ["Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30721", "l": "2-methyl-3-oxobutanoyl-CoA + CoA => acetyl-CoA + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400342", "l": "Expression of ARNTL (BMAL1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57673", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] => 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15011", "l": "7,8-dihydrofolate + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983148", "l": "Interaction of Erp57 with MHC class I HC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174202", "l": "Degradation of multiubiquitinated Securin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749505", "l": "LRRC14 binds IKBKB and CHUK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23016", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10473", "l": "(2R,3S)-2,3-dimethylmalate => propanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49346", "l": "2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74195", "l": "aspulvinone E + O2 = (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53656", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8862380", "l": "HSD17B13 binds lipid droplets (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690785", "l": "BAP1 binds Ub-HCFC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264865", "l": "Caspase-mediated cleavage of Lamin A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76046", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12714", "l": "a nucleoside 5'-phosphate + ATP => a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168337", "l": "Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856525", "l": "ANGPTL8 binds ANGPTL3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65408", "l": "NAD(+)(in) = NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1358791", "l": "Phosphorylation of USP8 by P-AKT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53893", "l": "an S-prenyl-L-cysteine + H2O + O2 => a prenal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77057", "l": "cyclopentanone + H(+) + NADPH + NH4(+) => cyclopentylamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008564", "l": "protein-exporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50550", "l": "H2O + prostaglandin A1 => prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45726", "l": "(E)-4-coumaraldehyde + H(+) + NADPH => (E)-4-coumaroyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035281", "l": "NR1H3 gene transcription regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16087", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015400", "l": "low-affinity secondary active ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59673", "l": "D-maltotriose + O2 => D-maltotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42451", "l": "(R)-2-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33102", "l": "acetyl-CoA + spermine <=> CoA + H(+) + N(1)-acetylspermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876731", "l": "CHEST translocates from ER membrane to lipid particle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905394", "l": "retromer complex binding", "d": ["Binding to a retromer complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635440", "l": "PapA5 transforms mycocerosyl to PDIM (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24141", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61297", "l": "5-deoxy-alpha-D-ribose 1-phosphate => 5-deoxy-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795134", "l": "Cipro is sulfonated to sulfo-Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753634", "l": "GGT dimers hydrolyse APAP-SG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73898", "l": "ATP + L-glutamate + spermine <=> ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53476", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112755", "l": "SOCS3 binds IL6ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16113", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.16.1.6", "l": "\"cyanocobalamin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0140296", "l": "general transcription initiation factor binding", "d": ["Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008073", "l": "ornithine decarboxylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ornithine decarboxylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32572", "l": "(E)-2-methylgeranyl diphosphate + H2O => 2-methylisoborneol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40774", "l": "(20S)-ginsenoside Rg1 + H2O <=> (20S)-ginsenoside F1 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75205", "l": "ADP + alpha,alpha-trehalose(in) + H(+) + phosphate => alpha,alpha-trehalose(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110322", "l": "Formation of Pol zeta complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67660", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16638", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine => [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44707", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51231", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate <=> 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32420", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58064", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin = 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33891", "l": "chanoclavine-I + NAD(+) = chanoclavine-I aldehyde + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.332", "l": "\"chanoclavine-I dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36157", "l": "A + Co-precorrin-4 + S-adenosyl-L-homocysteine => AH2 + Co(II)-factor III + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008508", "l": "bile acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212432", "l": "Formation of DRIP coactivator complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647977", "l": "ICMT methylates S-Farn RAS proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64972", "l": "dUDP + H2O = dUMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448632", "l": "IL34 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76501", "l": "N-acetyl-L-glutamate => N-acetyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62698", "l": "2 cornusiin E + 2 H2O => O2 + 4 tellimagrandin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50069", "l": "ATP + glycoursodeoxycholate(in) + H2O => ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170978", "l": "p-FRS2:CRKL binds C3G (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19682", "l": "ATP + biotin + CoA => AMP + biotinyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27870", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.13", "l": "\"2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264458", "l": "Proteasome mediated degradation of COP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17683", "l": "2-methyl-3-oxopropanoate + H(+) + NADH => 3-hydroxy-2-methylpropanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23818", "l": "4-aminobutanal + L-glutamate => 2-oxoglutarate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042602", "l": "riboflavin reductase (NADPH) activity", "d": ["Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28006", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 = formaldehyde + H2O2 + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009817", "l": "Acitretin binds to RAR:RXR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74220", "l": "H2O + L-seryl-tRNA(Thr) => L-serine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57824", "l": "dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001082", "l": "inulin binding", "d": ["Binding to inulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654573", "l": "Activated FGFR1 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37478", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18886", "l": "GDP-beta-L-fucose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62401", "l": "(1R,2S)-ephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48000", "l": "1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624948", "l": "KIF17 enters the cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28598", "l": "H2O + N-acetyl-L-lysine = acetate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810724", "l": "PI3 binds the bacterial surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60233", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76412", "l": "2',3'-cGAMP(out) + n H(+)(out) => 2',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73987", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + discoidol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23709", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3828025", "l": "DCN (decorin) degradation by MMP14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64212", "l": "an N-(fatty acyl)-L-isoleucine + H2O = a fatty acid + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38797", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202721", "l": "JAM2 binds JAM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27595", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956659", "l": "ABL1 phosphorylates YAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928640", "l": "PAKs phosphorylate MLC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350769", "l": "trans-Golgi Network Coat Activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835443", "l": "STAT1,STAT3 binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53645", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389352", "l": "Translocation of Vav1 to CD28 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72134", "l": "agmatine(out) <=> agmatine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869580", "l": "DEK binds TFAP2A homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40870", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9E)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14232", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41705", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961840", "l": "E2F1 binds the CCNE1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:1901681", "l": "sulfur compound binding", "d": ["Binding to a sulfur compound."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943279", "l": "GGT dimers hydrolyse GSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62038", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176298", "l": "Activation of claspin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67992", "l": "AH2 + trichloroethene = (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24825", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33035", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009392", "l": "N-acetyl-anhydromuramoyl-L-alanine amidase activity", "d": ["Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791109", "l": "GADD45A binds PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42546", "l": "pseudouridine(32) in tRNA => uridine(32) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37891", "l": "aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.95", "l": "\"aclacinomycin methylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140868", "l": "4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)", "d": ["Catalysis of the reaction: 3 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 3 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176318", "l": "Loading of claspin onto DNA during replication origin firing (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63143", "l": "H2O + N-tetracosanoyl-taurine <=> taurine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42537", "l": "uridine(65) in tRNA => pseudouridine(65) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205262", "l": "Direct recruitment of PI3K to p-KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008935", "l": "1,4-dihydroxy-2-naphthoyl-CoA synthase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210920", "l": "NEUROG3-dependent synthesis of NEUROD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706364", "l": "Internalization of ubiquitinated FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41863", "l": "(3R)-hydroxydecanoyl-[ACP] <=> (2E)-decenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.6", "l": "\"NAD(P)H-hydrate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71373", "l": "epitestosterone 17-sulfate(in) + 2 Na(+)(in) => epitestosterone 17-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204311", "l": "AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684290", "l": "nsp3 is glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49366", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047530", "l": "2,4-diaminopentanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28397", "l": "L-alanyl-L-glutamate <=> L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24315", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72559", "l": "estrone 3-sulfate(out) + pentanoate(in) = estrone 3-sulfate(in) + pentanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69785", "l": "2-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938887", "l": "PML binds RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47298", "l": "(2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein] => dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60655", "l": "an N-(acyl)-sphingosylphosphocholine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71122", "l": "H(+) + hispidin + NADPH + O2 <=> 3-hydroxyhispidin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72839", "l": "ADP(out) + CoA(in) = ADP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62309", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-malbrancheamide B + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70286", "l": "H2O + N-acetylputrescine + O2 <=> 4-acetamidobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68964", "l": "2-hydroxyoctadecanoate + O2 = 2-oxooctadecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686430", "l": "MUS81 binds EME1, EME2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74557", "l": "(S)-malate(in) => (S)-malate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015655", "l": "alanine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)."], "t": []}, {"i": "RHEA:29283", "l": "L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64527", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA <=> 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33840", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) => 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63614", "l": "prunetin-5-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75421", "l": "(S)-acetoin + H(+) + NADH => (R,S)-butane-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41612", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692315", "l": "OX40L binds OX40 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070694", "l": "deoxyribonucleoside 5'-monophosphate N-glycosidase activity", "d": ["Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base."], "t": []}, {"i": "REACT:R-HSA-8953339", "l": "DNPH1 hydrolyses dGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13000", "l": "(E)-feruloyl-CoA + galactarate <=> 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34286", "l": "2 L-tyrosine + O2 <=> 2 L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443783", "l": "Interaction of NUMB with L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50728", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350058", "l": "Formation of CSL NCOR corepressor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62116", "l": "H2O + iminosuccinate = NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031798", "l": "type 1 metabotropic glutamate receptor binding", "d": ["Binding to a type 1 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837376", "l": "RSV G binds CD209,CLEC4M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55755", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72552", "l": "glutarate(out) + urate(in) => glutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222376", "l": "NOX2 generates superoxide from oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23937", "l": "D-gluconate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64383", "l": "3 A + phytyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5622129", "l": "FABP5 binds atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22166", "l": "a globoside Forssman (d18:1(4E)) + H(+) + UDP => a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45275", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O <=> 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55069", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77686", "l": "a globoside Gb3Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> a globoside GalGb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33448", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) => 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660965", "l": "CCL17 and CCL22 genes are transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65342", "l": "CoA + O-acetyl-L-threonyl-[protein] => acetyl-CoA + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140764", "l": "small RNA binding translational repressor activity", "d": ["A translational repressor activity that binds to a single-stranded small regulatory RNA (either a miRNA or a siRNA) to guide it to its target mRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297275", "l": "CD9:Izumo Binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20094", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose => an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004067", "l": "asparaginase activity", "d": ["Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373745", "l": "SDK1 homophillic interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22259", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15629", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.4", "l": "\"steroid 11beta-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60066", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+) => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167118", "l": "NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53772", "l": "chenodeoxycholate + lithocholoyl-CoA = chenodeoxycholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30913", "l": "a carboxylate + sphing-4-enine-phosphocholine => a sphingomyelin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41108", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617853", "l": "GADD45A gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008260", "l": "succinyl-CoA:3-oxo-acid CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672083", "l": "KTN1 binds Kinesin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372819", "l": "PCK2 phosphorylates OA to yield PEP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204863", "l": "Interaction of Tie2 with Ang2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939929", "l": "ESRRA:PPARG1CA binds the RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804383", "l": "PRMT5 methylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12059", "l": "D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017491", "l": "RHOJ GEFs activate RHOJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44980", "l": "(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31888", "l": "(S)-2,3-epoxysqualene => tirucalladienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15997", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010855", "l": "adenylate cyclase inhibitor activity", "d": ["Binds to and decreases the activity of adenylate cyclase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705584", "l": "HMGCR dimer binds statins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19859", "l": "a 16-oxosteroid + H(+) + NADPH => a 16alpha-hydroxysteroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622363", "l": "CEBPA binds the promoter of the KLF5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190265", "l": "FGFR4 binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52750", "l": "2 isomaltose => alpha-isomaltosyl-(1->3)-isomaltose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21827", "l": "2-oxoglutarate + L-aspartate <=> L-glutamate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62288", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate = (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662986", "l": "MT2A binds copper (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.1", "l": "\"purine-nucleoside phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51490", "l": "archaetidylethanolamine + CO2 => archaetidylserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.57", "l": "\"leucyl endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68968", "l": "mandelate + O2 = H2O2 + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008267", "l": "ESR1 binds to TGFA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32608", "l": "(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-hydroxygeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31056", "l": "estrone 3-sulfate + H2O => estrone + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35197", "l": "L-quinate(out) => L-quinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73589", "l": "CTP(in) + UMP(out) => CTP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39098", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) <=> 3-oxodecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64778", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol => 3-sulfanylpentan-1-ol-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19000", "l": "CTP + H(+) + phosphocholine <=> CDP-choline + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10638", "l": "D-mannuronate + H(+) + NADPH => D-mannonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047510", "l": "(S)-2-methylmalate dehydratase activity", "d": ["Catalysis of the reaction: S-citramalate = H2O + mesaconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416562", "l": "p190RhoGAP binds Plexin-B1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77081", "l": "Formation of the CE:GMP intermediate complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22442", "l": "H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP => UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51711", "l": "D-altritol + NAD(+) <=> H(+) + keto-D-tagatose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52325", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] => 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21698", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65190", "l": "berkeleydione + CO2 + H2O + succinate => 2-oxoglutarate + berkeleyone B + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52900", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.3.3.7", "l": "\"Ni-sirohydrochlorin a,c-diamide reductive cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008999", "l": "peptide-alanine-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-peptide = CoA + H+ + N-terminal N-alpha-acetyl-L-alanyl-peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65007", "l": "ATP + decanoate + holo-[ACP] <=> AMP + decanoyl-[ACP] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49165", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004321", "l": "fatty-acyl-CoA synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392749", "l": "Transport of L1 into endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70830", "l": "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54759", "l": "deamido-NAD(+) + hydrogencarbonate <=> AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74476", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 => (-)-4'-methoxycyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.3", "l": "\"mannuronate-specific alginate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76491", "l": "(E)-ferulate + H2O = acetate + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.8", "l": "\"muramoylpentapeptide carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669893", "l": "KIT binds type I TKIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950778", "l": "p-Y693-STAT4 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42266", "l": "3-oxodecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031773", "l": "kisspeptin receptor binding", "d": ["Binding to a kisspeptin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54605", "l": "2-oxoglutarate + decanoyl-CoA + O2 => 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64264", "l": "atrochrysone carboxylate + H(+) = atrochrysone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17517", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate = a long-chain fatty acid + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.55", "l": "\"long-chain-fatty-acyl-glutamate deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31554", "l": "presqualene diphosphate <=> 15-cis-4,4'-diapophytoene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030506", "l": "ankyrin binding", "d": ["Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68518", "l": "beta-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44925", "l": "2-oxoadipate + acetyl-CoA + H2O => (R)-dihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24565", "l": "a 3-oxo acid + succinyl-CoA => a 3-oxoacyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72621", "l": "Ribosomal scanning  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67112", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60092", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.314050959231352", "identifiers": [{"i": "GO:0019104", "l": "DNA N-glycosylase activity", "d": ["Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25606", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O => 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74056", "l": "D-cysteine(out) + L-alanine(in) => D-cysteine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17198", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 => 2 4-hydroxyphenylacetate + 2 CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65181", "l": "AH2 + O2 + protoaustinoid B => A + H2O + preaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047624", "l": "adenosine-tetraphosphatase activity", "d": ["Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38060", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43054", "l": "3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate => 3-(methylsulfanyl)propanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50684", "l": "H2O + N(5)-phenyl-L-glutamine = aniline + H(+) + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.123", "l": "\"gamma-glutamylanilide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0141050", "l": "histone H3K deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine + H2O = histone H3 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990448", "l": "exon-exon junction complex binding", "d": ["Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62848", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052873", "l": "FMN reductase (NADPH) activity", "d": ["Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58950", "l": "4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374663", "l": "DCC interaction with Ezrin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611721", "l": "β1-agonists bind ADRB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72212", "l": "(+)-isoborneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36967", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37879", "l": "methyl aklanonate = aklaviketone", "d": [], "t": []}, {"i": "EC:5.5.1.23", "l": "\"aklanonic acid methyl ester cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11594", "l": "dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase] => dihydromonacolin L-[lovastatin nonaketide synthase] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429415", "l": "SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470009", "l": "Phosphorylation of STATs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982617", "l": "CYGB:O2 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380780", "l": "Activation of Src (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36843", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50950", "l": "a 2'-deoxyuridine in single-stranded DNA + NH4(+) => a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77370", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + CMP-N-acetyl-beta-neuraminate <=> [N-acetyl-alpha-D-neuraminosyl-(2->8)](n+1) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789160", "l": "Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018577", "l": "catechol 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050539", "l": "maleimide hydrolase activity", "d": ["Catalysis of the reaction: H2O + maleimide = H+ + maleamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17364", "l": "3-oxo-3-ureidopropanoate + H2O <=> H(+) + malonate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203977", "l": "SAR1 Activation And Membrane Binding (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858500", "l": "CLEC10A binds Tn-MUC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693148", "l": "BCKDK phosphorylates BCKDH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64170", "l": "(2S)-2-aminobutanoate + formaldehyde => 2-ethyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791069", "l": "Expression of ACADVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66229", "l": "asc-C13-CoA + O2 => asc-DeltaC13-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35625", "l": "gamma-D-glutamyl-D-glutamate + NH4(+) => D-glutamate + D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16145", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}, {"i": "EC:1.14.18.2", "l": "\"CMP-N-acetylneuraminate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2172666", "l": "RB1 binds condensin II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418925", "l": "ADORA2A,B bind Ade-Rib (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49940", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62934", "l": "acetate + cytidine + H(+) => H2O + N(4)-acetylcytidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204861", "l": "Interaction of Tie2 and Shc1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46328", "l": "L-threo-3-phenylserine = 3-phenylpyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45626", "l": "AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46858", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63027", "l": "(13Z)-docosenamide + H2O <=> (13Z)-docosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63107", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 <=> 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51333", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15411", "l": "1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51109", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19893", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.7", "l": "\"phosphooxymethylpyrimidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42958", "l": "5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(38) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005225", "l": "volume-sensitive anion channel activity", "d": ["Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell."], "t": []}, {"i": "REACT:R-HSA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36441", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31376", "l": "H(+) + pyrrole-2-carboxylate => 1H-pyrrole + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16522", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052659", "l": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685607", "l": "Sialic acid binds SIGLEC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399930", "l": "Activation of PAK by Rac1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31994", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquithujene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49817", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine => 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17597", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] = D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.2", "l": "\"mannitol dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674018", "l": "BRAP binds RAS:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45686", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(out) => N-dodecanoyl-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20657", "l": "4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.5.5", "l": "\"arylacetonitrilase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41222", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49484", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43753", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635842", "l": "ULK3 phosphorylates GLI (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24215", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP <=> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69747", "l": "(indol-3-yl)acetate + succinyl-CoA = (indol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39850", "l": "a 2-acylglycerol + ATP <=> a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28986", "l": "nitrite(in) <=> nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28657", "l": "glutathione + H(+) + sulfite => glutathione S,S-dioxide + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50999", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467716", "l": "AGRN binds Alpha-dystroglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050633", "l": "acetyl-CoA C-myristoyltransferase activity", "d": ["Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23301", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2Z,6E)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47133", "l": "11-cis-retinal + H2O + NAD(+) => 11-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202709", "l": "JAM2 dimerises (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75932", "l": "H2O + taurocyamine => taurine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54530", "l": "D-ribose 5-phosphate => aldehydo-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682388", "l": "Autophagosome maturation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61419", "l": "(S)-8-oxocitronellyl enol <=> cis-trans-nepetalactol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52559", "l": "3-dehydro-D-erythronate + ATP <=> 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48416", "l": "a ganglioside GA2 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM2 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33631", "l": "ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103092", "l": "methylthioalkylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(7'-methylthio)heptylmalate = 3-(7'-methylthio)heptylmalate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48826", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68894", "l": "3-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-methoxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65774", "l": "1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641206", "l": "RSPOs bind LGRs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75890", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] <=> ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45857", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1170539", "l": "Prolactin receptor is internalized (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31222", "l": "5-hydroxykynurenamine + CO2 <=> 5-hydroxy-L-kynurenine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47732", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68287", "l": "hexanoyl-CoA + L-seryl-[protein] <=> CoA + O-hexanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444572", "l": "Zinc is an agonist of GPR39 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160104", "l": "tRNA (guanine(26)-N2)-dimethyltransferase activity", "d": ["Catalysis of the reaction:guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68609", "l": "H(+) + isatin + NADPH => 3-hydroxyindolin-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24407", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75631", "l": "H2O + plasmodiophorol B = plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77248", "l": "H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15406", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) => [(3R)-hydroxybutanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45231", "l": "a (3E)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706837", "l": "AR binds AR antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76937", "l": "2-methylpropanal + H(+) + NADH + NH4(+) => 2-methylpropan-1-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74524", "l": "L-lysine + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50496", "l": "acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69221", "l": "a (Z)-glucosinolate + H2O => a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48517", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63060", "l": "5-methylorsellinate + ATP + H(+) + NADPH = 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15110", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) => (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17911", "l": "acetaldehyde + formate => (S)-lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60275", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070411", "l": "I-SMAD binding", "d": ["Binding to an inhibitory SMAD signaling protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850961", "l": "PREX2 binds PTEN and inhibits it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18237", "l": "2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.4", "l": "\"gentisate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0010297", "l": "heteropolysaccharide binding", "d": ["Binding to a heteropolysaccharide, a glycan composed of more than one type of monosaccharide residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22570", "l": "ascopyrone P => ascopyrone M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56092", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031732", "l": "CCR7 chemokine receptor binding", "d": ["Binding to a CCR7 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218806", "l": "FYN autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714580", "l": "SLC6A3 binds DRIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69514", "l": "H(+) + H2O2 + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67498", "l": "3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14356", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) <=> CO2 + L-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190260", "l": "FGFR2b binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77079", "l": "2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + N,N-dimethyl-cadaverine = H(+) + pre-flavunoidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40599", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15421", "l": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.3", "l": "\"long-chain-fatty-acid--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27450", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018705", "l": "1,2-dichloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928577", "l": "ROCK phosphorylates LIMK1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640167", "l": "RRAGA,B exchanges GDP for GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850534", "l": "PDCL promotes G-protein beta 5 folding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62039", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190829", "l": "Lysosomal degradation of gap junction plaques (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70994", "l": "H(+)(in) + L-mannopyranose(in) <=> H(+)(out) + L-mannopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418662", "l": "Src activation following P2Y purinoceptor activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674018", "l": "BRAP binds RAS:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592270", "l": "NID1 degradation by MMP1, 9, 12, ELANE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052832", "l": "inositol monophosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871266", "l": "YAP1 binds TEAD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73774", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032132", "l": "O6-alkylguanine-DNA binding", "d": ["Binding to an O6-alkylguanine adduct in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16181", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.82", "l": "\"3-methylquercetin 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707683", "l": "PGRMC2 binds Hemes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168888", "l": "Alpha1-Microglobulin binds heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55246", "l": "4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54221", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene => all-trans-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189069", "l": "sucrose + H2O => glucose + fructose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66347", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37610", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10537", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72819", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50640", "l": "2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70504", "l": "H2O + isopentenyl diphosphate => H(+) + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813740", "l": "GDE1 hydrolyzes GroPIns (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163310", "l": "TFAM binds to mitochondrial promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58726", "l": "H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine => adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714481", "l": "RAC2 binds effectors at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102956", "l": "UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140935", "l": "histone H2B conserved C-terminal lysine deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from the conserved C-terminal lysine residue of a histone H2B protein to which it is conjugated. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49108", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27381", "l": "(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.80", "l": "\"2,3-bisphosphoglycerate 3-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29485", "l": "(+)-beta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140395", "l": "averantin hydroxylase activity", "d": ["Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70860", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) => L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50323", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67709", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63173", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA => (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203979", "l": "Coat Assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015056", "l": "corticotrophin-releasing factor receptor activity", "d": ["Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63427", "l": "(2S)-2-phospholactate + GTP + H(+) <=> (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63211", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal <=> 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.53", "l": "\"methylenetetrahydrofolate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001792", "l": "polymeric immunoglobulin receptor activity", "d": ["Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38690", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O <=> (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68314", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647632", "l": "CASP3 cleaves GSDME (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373075", "l": "Metabotropic glutamate receptors bind glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0042947", "l": "glucoside transmembrane transporter activity", "d": ["Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43380", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] = L-arginyl-[protein] + phosphate", "d": [], "t": []}, {"i": "EC:3.9.1.2", "l": "\"protein arginine phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-166015", "l": "Association of LBP with LPS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198508", "l": "MDH1 oxidizes MAL to OA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.46", "l": "\"pyrimidine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975866", "l": "MyD88 forms a complex with the activated TLR receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374701", "l": "Phosphorylation of DCC by Fyn (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172433", "l": "Collagen type XIX degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49959", "l": "5,10-dihydrophenazine 1-carboxylate + O2 <=> H2O2 + phenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59251", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA <=> (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944262", "l": "Association of procollagen type X (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37178", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362522", "l": "ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40608", "l": "1-tetradecanoyl-sn-glycerol + H2O => glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73193", "l": "(2R,3S,11R)-acetylaszonalenin + CoA => (2R,3S,11R)-aszonalenin + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32741", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047298", "l": "(S)-3-amino-2-methylpropionate transaminase activity", "d": ["Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943279", "l": "GGT dimers hydrolyse GSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32137", "l": "CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => 2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68620", "l": "cortisone + H(+) + NADPH = 20beta-dihydrocortisone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55313", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42863", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34060", "l": "agroclavine + NADP(+) => didehydroagroclavine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20590", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65197", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine => H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50301", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850945", "l": "Casein kinase II phosphorylates PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211346", "l": "NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12163", "l": "2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31131", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43935", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) <=> androst-5-ene-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35720", "l": "(3S)-versiconol acetate + H2O => (S)-versiconol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74034", "l": "L-alanine(in) + L-cysteine(out) <=> L-alanine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507871", "l": "Aquaporins passively transport glycerol out of cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48974", "l": "ADP + H(+) + phosphate + phosphite(in) => ATP + H2O + phosphite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45255", "l": "tetradecanoate(out) <=> tetradecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25185", "l": "1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34871", "l": "methanol(out) = methanol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50933", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19335", "l": "CO2 + formyl-CoA => H(+) + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54992", "l": "3 A + FMN + H2O + L-glutamate + O2 = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": [], "t": []}, {"i": "EC:2.6.1.114", "l": "\"8-demethyl-8-aminoriboflavin-5'-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695964", "l": "ABHD14B hydrolyses PNPB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20753", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O => AH2 + 2 aquacob(III)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23473", "l": "2 alpha,alpha'-trehalose 6-mycolate => alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.116", "l": "\"D-arabinose 1-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481007", "l": "Exocytosis of platelet alpha granule contents (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700175", "l": "Active ALK phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75040", "l": "acetyl-CoA(in) => acetyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34499", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] = H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": [], "t": []}, {"i": "EC:1.14.15.11", "l": "\"pentalenic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390886", "l": "HRH4 binds Hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56297", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] => pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399930", "l": "Activation of PAK by Rac1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41974", "l": "a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+) => a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65754", "l": "(3R)-3-hydroxy-L-glutamate + CO2 + succinate => 2-oxoglutarate + L-glutamate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18980", "l": "a quinone + sn-glycerol 3-phosphate <=> a quinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15107", "l": "H(+) + kaempferide + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67485", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187746", "l": "RIT/RIN are activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5195402", "l": "CDK1 phosphorylates LPIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39854", "l": "2 a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215295", "l": "USP7 deubiquitinates MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047369", "l": "succinate-hydroxymethylglutarate CoA-transferase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20578", "l": "3-hydroxyaminophenol => aminohydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139906", "l": "Activation of BAD by calcineurin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37886", "l": "acetyl-CoA + oxalate <=> acetate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22423", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) <=> 2 H(+) + maleylacetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225949", "l": "Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653957", "l": "Rag dimer formation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24229", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) => 4-methylcatechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60368", "l": "urate(out) = urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140620", "l": "DNA strand exchange inhibitor activity", "d": ["Binds to and stops, prevents or reduces a DNA strand exchange activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17961", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = H2O + leukotriene A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66987", "l": "3-methylbutanoyl-CoA + H2O <=> 3-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.5", "l": "\"cytidine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.2", "l": "\"pyrroline-5-carboxylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102146", "l": "tricetin O-methytransferase activity", "d": ["Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75381", "l": "L-homoserine + N-hydroxyguanidine => H2O + L-canavanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990460", "l": "leptin receptor binding", "d": ["Binding to a leptin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193399", "l": "Cholate is translocated from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65157", "l": "2-oxoglutarate + O2 + preaustinoid A2 => CO2 + H2O + preaustinoid A3 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64825", "l": "1-naphthaleneacetamide + H2O => 1-naphthaleneacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46595", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691131", "l": "CANDI binds CUL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13338", "l": "D-glucurono-6,2-lactone + H2O => D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24031", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 <=> carnitine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45581", "l": "D-galactaro-1,5-lactone => D-galactaro-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71081", "l": "cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20061", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38826", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52004", "l": "H2O + methylglyoxal + NAD(+) = 2 H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32577", "l": "(1R,5R)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28883", "l": "H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39702", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA <=> (2E,13Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62034", "l": "a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48797", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140619", "l": "DNA strand exchange activator activity", "d": ["Binds to and increases a DNA strand exchange activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390673", "l": "CHRM2,4 bind acetylcholine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61145", "l": "myricetin + UDP-beta-L-rhamnose => H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61890", "l": "diosgenin 3-O-beta-D-glucoside + H(+) + UDP => diosgenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372742", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70671", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5444523", "l": "Formation of MSH1:PMS2 Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30699", "l": "2-oxoglutarate + beta-alanine = 3-oxopropanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.120", "l": "\"beta-alanine--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676596", "l": "TRAF3 binds BAFFR:BAFF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618093", "l": "ATP hydrolysis by HSP90 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76419", "l": "2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase] = (8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28441", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20151", "l": "3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + quinine + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033811", "l": "flavonol-3-O-triglucoside O-coumaroyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46562", "l": "5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53736", "l": "a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655046", "l": "Cleavage of FXII variant by KLKB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28235", "l": "L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33551", "l": "an N-acylsphinganine + H2O = a fatty acid + sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43933", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) => androst-5-ene-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693111", "l": "RHOF auto-activates (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50765", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804188", "l": "PRDM1 represses TP53 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.2.-", "l": "\"Acid--alcohol ligases (ester synthases)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69610", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38904", "l": "a sphingomyelin(in) + ATP + H2O => a sphingomyelin(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.23", "l": "\"DNA-formamidopyrimidine glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68309", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26294", "l": "(1'S,5'S)-averufin + NADPH + O2 => 1'-hydroxyversicolorone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202459", "l": "Phosphorylation of Bcl10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017065", "l": "single-strand selective uracil DNA N-glycosylase activity", "d": ["Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA."], "t": []}, {"i": "REACT:R-HSA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0031490", "l": "chromatin DNA binding", "d": ["Binding to DNA that is assembled into chromatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44353", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide C + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64593", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10026", "l": "H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => L-lysyl-[histone] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17022", "l": "(2-aminoethyl)phosphonate + pyruvate => L-alanine + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48750", "l": "D-erythrulose + H(+) + NADH => D-threitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56287", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) <=> a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64202", "l": "a fatty acid + L-leucine => an N-(fatty acyl)-L-leucine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033795", "l": "betaine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40055", "l": "1,2,3-trioctanoylglycerol + H2O = 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16099", "l": "acetate + H(+) + pyruvate => acetylpyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033893", "l": "ribonuclease IV activity", "d": ["Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70682", "l": "glycine betaine(in) + H(+)(in) <=> glycine betaine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449058", "l": "Interleukin-1 family are secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68260", "l": "D-serine(in) + Na(+)(in) = D-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50748", "l": "H2O + juglone = naphthalene-1,2,4,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55757", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 => a 2-hydroxyornithine lipid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052611", "l": "beta-carotene 3-hydroxylase activity", "d": ["Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198508", "l": "MDH1 oxidizes MAL to OA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75807", "l": "Na(+)(out) + propanoate(out) = Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25689", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) <=> L-cysteinyl-tRNA(Cys) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0032357", "l": "oxidized purine DNA binding", "d": ["Binding to a DNA region containing an oxidized purine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432129", "l": "FGR binds and phosphorylates LRP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112436", "l": "Formation of Elongin complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44714", "l": "a 1-acylglycerol + a fatty acid + H(+) => a 1,2-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59639", "l": "D-xylotriose + O2 <=> D-xylotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008815", "l": "citrate (pro-3S)-lyase activity", "d": ["Catalysis of the reaction: citrate = acetate + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637792", "l": "PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48662", "l": "8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47282", "l": "4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110311", "l": "POLZ extends translesion synthesis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74244", "l": "H2O + L-alanyl-tRNA(Pro) => H(+) + L-alanine + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57897", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26423", "l": "3'-phosphoadenylyl sulfate + thyroxine => adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608855", "l": "PRICKLE1 is degraded by the proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434989", "l": "SEMA7A binds to PLXNC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58731", "l": "adenosine in rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37287", "l": "ATP + H2O + L-alanyl-L-leucine(out) = ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58326", "l": "cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044102", "l": "purine deoxyribosyltransferase activity", "d": ["Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73668", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine => (E,E)-piperlonguminine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.66", "l": "\"beta-selinene cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17068", "l": "(R)-mevalonate + ATP <=> (R)-5-phosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21795", "l": "NADP(+) + propan-2-ol <=> acetone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65880", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A = 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37640", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.49", "l": "\"glucose-6-phosphate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568737", "l": "AP-1 transcription factor binds IL1A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52882", "l": "16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48046", "l": "D-galactose + ganglioside GM2 (d18:1(4E)/18:0) => ganglioside GM1 (d18:1(4E)/18:0) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38366", "l": "1-octadecanoylglycerol + H2O <=> glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712088", "l": "ALK fusion proteins bind IRS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56802", "l": "cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44446", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63580", "l": "20-hydroxyecdysone 22-phosphate + H2O = 20-hydroxyecdysone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69557", "l": "D-glucose(out) + H(+)(out) => D-glucose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909718", "l": "Formation of p-STAT1 homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64029", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19397", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}, {"i": "EC:6.3.2.5", "l": "\"phosphopantothenate--cysteine ligase (CTP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50384", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69149", "l": "H2O + O2 + spermine => H2O2 + NH4(+) + spermine monoaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47346", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin] => 7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47106", "l": "5,6,7,8-tetrahydromethanopterin + L-serine => 5,10-methylenetetrahydromethanopterin + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417908", "l": "P2RY1 binds ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26212", "l": "L-allo-threonine <=> acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28678", "l": "alpha-D-galactose <=> beta-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60096", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58255", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] <=> ADP-D-ribose + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828724", "l": "NS1 (1C) mRNA is translated into protein NS1 (1C) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48763", "l": "L-threitol + NAD(+) <=> H(+) + L-erythrulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12182", "l": "H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005275", "l": "amine transmembrane transporter activity", "d": ["Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008949", "l": "oxalyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: H+ + oxalyl-CoA = CO2 + formyl-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114683", "l": "Phosphorylation of Platelet Sec-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72807", "l": "L-histidine(out) = L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875568", "l": "RAPGEF1 activates RAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32031", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-curcumene", "d": [], "t": []}, {"i": "EC:4.2.3.94", "l": "\"gamma-curcumene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653974", "l": "Ragulator binds Rag dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047541", "l": "2-furoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638845", "l": "CERK phosphorylates CERA to form C1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36345", "l": "2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+) => 2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70170", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67940", "l": "2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68051", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine <=> [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29154", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376122", "l": "DSCAM/DSCAML1 homodimerization (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60198", "l": "CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33621", "l": "AMP + diphosphate + tetradecanoyl-CoA => ATP + CoA + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71237", "l": "[3Fe-4S](0)-[protein] + Fe(3+)-[Dph3] => [3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031808", "l": "H2 histamine receptor binding", "d": ["Binding to a H2 histamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19667", "l": "6-carboxyhex-2-enoyl-CoA + H(+) + NADH => 6-carboxyhexanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917693", "l": "ESCRT Disassembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3857336", "l": "CEBPB homodimerization (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55207", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741411", "l": "CYLD deubiquitinates NEMO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40460", "l": "(2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36949", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.976908003308438", "identifiers": [{"i": "GO:0016706", "l": "2-oxoglutarate-dependent dioxygenase activity", "d": ["Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21233", "l": "L-histidine => NH4(+) + trans-urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0015215", "l": "nucleotide transmembrane transporter activity", "d": ["Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52059", "l": "12-hexadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64199", "l": "an N-(fatty acyl)-L-lysine + H2O <=> a fatty acid + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36491", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649108", "l": "HTR3A pentamer binds 5HT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66724", "l": "(S)-lactate + L-phenylalanine = H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76539", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine = an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66973", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64165", "l": "2-methyl-L-serine => formaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34085", "l": "a (3S)-3-hydroxyacyl-CoA => a (3R)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72881", "l": "NH4(+) + phosphonoacetaldehyde => (1R)-(2-amino-1-hydroxyethyl)phosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655832", "l": "Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042013", "l": "interleukin-19 binding", "d": ["Binding to interleukin-19."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21457", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19109", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.143", "l": "\"beta-glucogallin--tetrakisgalloylglucose O-galloyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730835", "l": "Autophosphorylation of PKC-theta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76697", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14136", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44037", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O => 12,13-dihydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912790", "l": "CBL binds CRK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.1", "l": "\"NAD(P)(+) transhydrogenase (Si-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48779", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74715", "l": "Autophosphorylation of insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51798", "l": "colupulone + diphosphate + H(+) => deoxycohumulone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614614", "l": "Cysteine is degraded to serine and H2S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047801", "l": "L-cysteine transaminase activity", "d": ["Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57324", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651792", "l": "LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757256", "l": "MCM3 binds MCM5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692154", "l": "SOX9 binds the PTGDS gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482770", "l": "Release of platelet secretory granule components (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53502", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46097", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + dihydropinosylvin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18909", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.136", "l": "\"chlorophenol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41564", "l": "aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.326", "l": "\"aklavinone 7-L-rhodosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43121", "l": "2-oxoglutarate + O2 + xanthine => CO2 + succinate + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45831", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114563", "l": "Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17169", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.276", "l": "\"galactosamine-1-phosphate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67033", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16902", "l": "acetyl-CoA + L-2,4-diaminobutanoate => (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33308", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57876", "l": "uridine(54) in tRNA = pseudouridine(54) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134901", "l": "LRR FLII-interacting protein 1 associates with beta-catenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68823", "l": "(2Z,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786789", "l": "FLT3LG dimer binds FLT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952069", "l": "HDAC4 deacetylates RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10015", "l": "(R)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54141", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56523", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52591", "l": "choloyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606784", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48569", "l": "3-chlorocatechol + O2 => (2E,4Z)-2-chloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44729", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12496", "l": "2 Fe(2+) + 4 H2O + O2 = 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952419", "l": "SMURFs ubiquitinate RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3321805", "l": "NSL acetylates histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77118", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O <=> 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68466", "l": "2-butyloctan-1-ol + H(+) + sulfate => 2-butyloctyl sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24471", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 <=> H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.14", "l": "\"rhodopsin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67885", "l": "3'-phosphoadenylyl sulfate + dopamine => adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45046", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrite => 2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34671", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69014", "l": "5beta-androstane-3beta,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018798", "l": "RHOV binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28751", "l": "sn-glycerol 3-phosphate + ubiquinone-8 = dihydroxyacetone phosphate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63962", "l": "abscisate(in) + ADP + H(+) + phosphate => abscisate(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71460", "l": "H2O + substance P => L-Leu-L-Met-NH2 + substance P(1-9)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73594", "l": "CTP(out) + dUTP(in) <=> CTP(in) + dUTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102180", "l": "4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ = 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63419", "l": "2,6-dichlorohydroquinone + FADH2 + O2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391158", "l": "SIRP alpha binds CD47 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016913", "l": "follicle-stimulating hormone activity", "d": ["The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37759", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69695", "l": "H(+) + menadione + NADH = menadiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54174", "l": "2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.93", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201611", "l": "Caspase-mediated cleavage of Rock-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016631", "l": "enoyl-[acyl-carrier-protein] reductase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73767", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate = diphosphate + preechinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018478", "l": "malonate-semialdehyde dehydrogenase (acetylating) activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66931", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O <=> a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9834807", "l": "ILF3 binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34996", "l": "L-rhamnose(in) => L-rhamnose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102323", "l": "2-isopropylphenol monooxygenase activity", "d": ["Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836500", "l": "IKK complex is activated by PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26477", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate <=> alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674015", "l": "Olaratumab binds PDGFRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26255", "l": "2 H2O + isopimara-7,15-dienal + NADP(+) => H(+) + isopimara-7,15-dienol + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23480", "l": "2-methylene-3-methylsuccinate = dimethylmaleate", "d": [], "t": []}, {"i": "EC:5.3.3.6", "l": "\"methylitaconate Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18649", "l": "D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419389", "l": "LPA-binding receptors bind LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374298", "l": "Opioid receptors bind opioid peptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183122", "l": "Factor D cleaves C3b-bound Factor B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56663", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20103", "l": "AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein] => a long-chain fatty acid + ATP + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.5", "l": "\"haloalkane dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54893", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32706", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> 8-hydroxycopalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611158", "l": "Fusion of HCMV Envelope with Plasma Membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159796", "l": "Furin cleaves pro-factor IX to factor IX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69154", "l": "acrolein + spermidine => spermine monoaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43783", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665761", "l": "FMNL3 binds RHOC:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193646", "l": "NGF binding to p75NTR inactivates RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734730", "l": "ORC1 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34364", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264834", "l": "Endocytosis and degradation of apoA-I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29287", "l": "2 H(+)(in) + L-aspartate(in) = 2 H(+)(out) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429101", "l": "HMIT co-transports myo-inositol with a proton (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211224", "l": "Association of DFF40 with DFF45 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835944", "l": "ADAR1 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54284", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10568", "l": "luteolin + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.189", "l": "\"luteolin 7-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11011", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102218", "l": "starch, H2O dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56849", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine => H(+) + reumycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005157", "l": "macrophage colony-stimulating factor receptor binding", "d": ["Binding to a macrophage colony-stimulating factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692867", "l": "HRH3 binds pitosilant (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685838", "l": "CX3 complex binds D-loop structures (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19802", "l": "(R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212432", "l": "Formation of DRIP coactivator complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23682", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphate => a ribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174157", "l": "Degradation of multiubiquitinated Cyclin B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62685", "l": "norrubrofusarin + S-adenosyl-L-methionine => H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73572", "l": "(E,E)-piperate + ATP + CoA => (E,E)-piperoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39528", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55345", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol => 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20619", "l": "H(+) + H2O2 + L-ascorbate => L-galactono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18987", "l": "isochorismate => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46929", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53405", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53854", "l": "7-oxo-glycodeoxycholate + H(+) + NADH => glycocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52234", "l": "3 A + Fe(2+) + 3 H2O + mycobilin a => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75497", "l": "n H(+)(in) + pregnenolone sulfate(in) => n H(+)(out) + pregnenolone sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44933", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442715", "l": "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874138", "l": "ATF6B (ATF6-beta) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061897", "l": "all-trans retinal 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73707", "l": "ATP(in) + UDP(out) = ATP(out) + UDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29618", "l": "alpha-maltotriose + beta-maltose <=> alpha-maltotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15218", "l": "ecdysone + hexadecanoyl-CoA => CoA + ecdysone hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11933", "l": "2-hydroxy-2-methylpropanenitrile => acetone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678927", "l": "UNC93B1 delivers endosomal full-length TLRs to endolysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33342", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59308", "l": "D-galactono-1,5-lactone + H2O = D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58325", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58185", "l": "H(+) + NADPH + 2 phytyl diphosphate => (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.51", "l": "\"4-hydroxyphenylalkanoate adenylyltransferase FadD29\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11373", "l": "ATP + L-aspartate + NH4(+) => AMP + diphosphate + H(+) + L-asparagine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727944", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65396", "l": "8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047777", "l": "(S)-citramalyl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56394", "l": "(3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693148", "l": "BCKDK phosphorylates BCKDH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65100", "l": "a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26443", "l": "a ubiquinone + ethanol => a ubiquinol + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28602", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.39", "l": "\"isoleucine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14015", "l": "adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate => 3'-phosphoadenylyl sulfate + taurolithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17229", "l": "acetyl-CoA + an aliphatic alcohol = an acetyl ester + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.84", "l": "\"alcohol O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003871", "l": "5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43465", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70317", "l": "cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine => beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186747", "l": "Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31452", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) => a cardiolipin + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77739", "l": "a 1,2-diacylglycerol + a glycerophospholipid = a 1-acyl-sn-glycero-3-phospholipid + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73586", "l": "CTP(out) + UDP(in) <=> CTP(in) + UDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31413", "l": "a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357828", "l": "RIPK1 is cleaved by CASP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57453", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252133", "l": "ATP6AP1 binds V-ATPase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.194", "l": "\"ginsenosidase type IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606789", "l": "ARSB hydrolyses DS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.15", "l": "\"aminopeptidase Y\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114683", "l": "Phosphorylation of Platelet Sec-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3828025", "l": "DCN (decorin) degradation by MMP14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676589", "l": "RANKL,sRANKL trimer binds RANK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651789", "l": "LIG1 bound to POLB ligates SSB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813626", "l": "LEAP2 binds bacteria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205649", "l": "p62 links damaged mitochondria to LC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28305", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707586", "l": "FeHM oxidises LDL,HDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38900", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56329", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O => 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43848", "l": "[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-disulfide + arsenite + H2O", "d": [], "t": []}, {"i": "EC:1.20.4.4", "l": "\"arsenate reductase (thioredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71660", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] => a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18936", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0042083", "l": "5,10-methylenetetrahydrofolate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72694", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47550", "l": "3-oxochola-4,6-dien-24-oate + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670619", "l": "Defective ATRX does not bind DAXX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114558", "l": "Thrombin-activated PARs activate Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14162", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11338", "l": "deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156908", "l": "eEF1A:GTP:aminoacyl tRNA ternary complex formation. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29501", "l": "(+)-alpha-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35789", "l": "H(+) + kanamycin C + UDP => paromamine + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71691", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679775", "l": "COMT binds COMT Inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030781", "l": "6-O-methylnorlaudanosoline 5'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11727", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite <=> 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11163", "l": "2-oxoglutarate + L-2,4-diaminobutanoate <=> L-aspartate 4-semialdehyde + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14449", "l": "chlorophyllide a + NADP(+) = 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66337", "l": "L-glutamate(out) => L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432295", "l": "GPVI binds Fyn and Lyn (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374669", "l": "L1 binds NRP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944352", "l": "TCF/LEF binds WNT promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53504", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": [], "t": []}, {"i": "EC:4.1.99.23", "l": "\"5-hydroxybenzimidazole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43799", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805981", "l": "HMGB1 release from cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607838", "l": "Defective UNC93B1 does not bind TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109858", "l": "MAP2K2 binds MAPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13408", "l": "4-coumaroyl-CoA + agmatine <=> CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58656", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20237", "l": "(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13736", "l": "an n-alkanal + NAD(+) <=> an alk-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66145", "l": "5-methoxytryptamine + acetyl-CoA => CoA + H(+) + melatonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416929", "l": "PTGFR binds PGF2a (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48739", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36802", "l": "a ribonucleoside 5'-diphosphate + H2O <=> a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11643", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102266", "l": "tRNA-dihydrouridine20a synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) = H+ + a uracil20a in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977224", "l": "Serum amyloid P binds DNA and chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.18", "l": "\"ATP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070080", "l": "titin Z domain binding", "d": ["Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102864", "l": "1-18:3-2-18:2-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47269", "l": "bacterioruberin => H2O + monoanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953111", "l": "E2F6 binds TFDP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59731", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-ethylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72580", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730843", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785047", "l": "IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66320", "l": "2',3'-cGAMP(out) = 2',3'-cGAMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74316", "l": "O-isobutanoyl-(R)-carnitine(in) => O-isobutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55273", "l": "11-cis-retinol + tetradecanoyl-CoA => 11-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450088", "l": "GLUT1 tetramer binds 4xATP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72223", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) = 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418553", "l": "cAMP degradation by Phosphodiesterases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016756", "l": "glutathione gamma-glutamylcysteinyltransferase activity", "d": ["Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102878", "l": "(+)-alpha-barbatene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-alpha-barbatene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51717", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225919", "l": "Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53286", "l": "3-dehydro-scyllo-inosose + H(+) + NADH => NAD(+) + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111883", "l": "Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77688", "l": "a ganglioside GD1a (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GalNAc-GD1a (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44196", "l": "3-methylundecanoate + ATP + CoA = 3-methylundecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66434", "l": "H(+)(in) + L-galactose(in) => H(+)(out) + L-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69681", "l": "apigenin + beta-D-glucose => apigenin 7-O-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700997", "l": "TP53 binds the MDM2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45052", "l": "(2E)-butenoyl-CoA + (R)-carnitine = CoA + O-(2E)-butenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730902", "l": "Oligomerization of p-CARMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193656", "l": "p75NTR interacts with RIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047914", "l": "gamma-glutamylhistamine synthase activity", "d": ["Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44839", "l": "a globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose <=> a globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20794", "l": "AMP + diphosphate + L-lysyl-tRNA(Lys) => ATP + L-lysine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.136", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944254", "l": "Association of procollagen type XXVI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.1", "l": "\"dual-specificity kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51360", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23987", "l": "cholesterol + NADP(+) <=> 7-dehydrocholesterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.-", "l": "\"Miscellaneous\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23845", "l": "ATP + sedoheptulose => ADP + D-sedoheptulose 7-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198732", "l": "STAT3 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186773", "l": "PDGF dimer binds two receptors simultaneously (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70373", "l": "CoA + H(+) + N-decanoyl-3-oxosphinganine => 3-oxosphinganine + decanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701485", "l": "Active ALK binds JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416562", "l": "p190RhoGAP binds Plexin-B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52267", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine <=> gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791109", "l": "GADD45A binds PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41069", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40466", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19056", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875817", "l": "MET phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35985", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56165", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16883", "l": "2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0016670", "l": "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.8.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51665", "l": "D-5-phenylhydantoin + H2O => H(+) + N-carbamoyl-D-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64342", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate => (2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45425", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781922", "l": "USP13 binds UFD1L:SKP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213244", "l": "Loading of antigenic peptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61585", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25156", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}, {"i": "EC:6.3.2.51", "l": "\"phosphopantothenate--cysteine ligase (ATP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35150", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11402", "l": "4'-O-demethylsordarin + GDP + H(+) => GDP-6-deoxy-alpha-D-altrose + sordaricin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080076", "l": "caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74333", "l": "O-butanoyl-(R)-carnitine(out) => O-butanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928641", "l": "PAK binds RAC and bPIX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52538", "l": "AMP + dGDP + H(+) => adenosine + dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11865", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine => dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30897", "l": "3-aminopropanal + H2O2 + NH4(+) => H2O + O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873917", "l": "Translocation of STAT1 dimer to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23194", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67576", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0016273", "l": "arginine N-methyltransferase activity", "d": ["Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28504", "l": "H(+) + NADH + S-formylmycothiol => NAD(+) + S-(hydroxymethyl)mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25210", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75643", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018817", "l": "2-oxo-hept-3-ene-1,7-dioate hydratase activity", "d": ["Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818578", "l": "Cleaved KMT2B dimers translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63237", "l": "ATP + streptomycin => 6-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399999", "l": "AKT1 E17K mutant phosphorylates RSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24772", "l": "7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696958", "l": "USP44 deubiquitinates CDC20 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21483", "l": "2-furoyl-CoA + A + H2O <=> 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395764", "l": "atREs binds to nascent CM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693243", "l": "RHOD translocates to the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62677", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide => 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332388", "l": "Activation of MAP3K7 in response to WNT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102508", "l": "cyanidin 3,7-diglucoside glucosidase activity", "d": ["Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O = cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31765", "l": "4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid => a 2-oxocarboxylate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047650", "l": "alkylglycerone kinase activity", "d": ["Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614933", "l": "ACEIs bind ACE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354077", "l": "Integrin alphaIIb beta3 activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61485", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42441", "l": "L-aspartate + NAD(+) => H(+) + iminosuccinate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070016", "l": "armadillo repeat domain binding", "d": ["Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24545", "l": "H2O + L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23004", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5615668", "l": "AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69864", "l": "a uridine in mRNA + S-adenosyl-L-methionine => a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944240", "l": "Association of procollagen type III (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68478", "l": "a fatty aldehyde + CO2 + H2O => a (2R)-2-hydroperoxy fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72569", "l": "dehydroepiandrosterone 3-sulfate(out) + propanoate(in) => dehydroepiandrosterone 3-sulfate(in) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12333", "l": "ATP + Fe(3+)(out) + H2O => ADP + Fe(3+)(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47598", "l": "an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP => an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609310", "l": "β-blockers bind ADRB1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40421", "l": "3,7,11,15-tetramethylhexadecanoate + CoA + H(+) => H2O + phytanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560491", "l": "Expression of CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814153", "l": "ADO oxidises 2AET to HTAU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69068", "l": "RFC dissociates after sliding clamp formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23398", "l": "1,3,5-trihydroxybenzene + H(+) + phloretate => H2O + phloretin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757688", "l": "SERPINA6 binds PREDN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29225", "l": "dihydroxyacetone phosphate + menaquinol-8 => menaquinone-8 + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72631", "l": "Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018774", "l": "RHOBTB1 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804741", "l": "MDM2 forms homo- or heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31834", "l": "(2E,6E)-farnesyl diphosphate <=> delta-guaiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58065", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin => 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54953", "l": "ATP + CoA + nonanoate => AMP + diphosphate + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74733", "l": "Insulin receptor de-phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685319", "l": "CX3 complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24065", "l": "2 5-aminolevulinate => H(+) + 2 H2O + porphobilinogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53069", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate => 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036431", "l": "dCMP kinase activity", "d": ["Catalysis of the reaction: ATP + dCMP = ADP + dCDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14156", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine <=> 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061730", "l": "C-rich strand telomeric DNA binding", "d": ["Binding to C-rich, single-stranded, telomere-associated DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34709", "l": "5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane => AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626816", "l": "PIN1 binds p-S345-NCF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22104", "l": "2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.80", "l": "\"nicotianamine aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033402", "l": "UUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624951", "l": "TNPO1 binds KIF17 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70032", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508513", "l": "PTK2B binds JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674022", "l": "BRAP autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15085", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": [], "t": []}, {"i": "EC:3.2.1.49", "l": "\"alpha-N-acetylgalactosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62140", "l": "dTMP + GTP = dTDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63897", "l": "aspulvinone E + hnu => isoaspulvinone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22802", "l": "obtusifoliol => cycloeucalenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24424", "l": "2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate", "d": [], "t": []}, {"i": "EC:1.8.5.1", "l": "\"glutathione dehydrogenase (ascorbate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30476", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate => D-glucuronate + H(+) + oroxylin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70390", "l": "3-oxosphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61200", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158849", "l": "Phenol can form a sulfate conjugate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31739", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine = a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.46", "l": "\"isoflavone 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71171", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) = H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18632", "l": "ATP + NAD(+) <=> ADP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689630", "l": "BAP1 binds BAP1-interacting complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38807", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35736", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.16", "l": "\"D-alanine--alanyl-poly(glycerolphosphate) ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57144", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59001", "l": "H2O + O2 + propanal => H(+) + H2O2 + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114264", "l": "Translocation of activated BAX to the mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029690", "l": "Caspase-6 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33274", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31215", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38133", "l": "1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034520", "l": "2-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23294", "l": "ADP + H(+) + N-phospho-L-lombricine => ATP + L-lombricine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018509", "l": "cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928604", "l": "SFKs phosphorylate VAV2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30821", "l": "allantoate + H(+) => allantoin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674019", "l": "BRAP binds KSR1:MARK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25352", "l": "H2O + L-cysteinyl-tRNA(Pro) => H(+) + L-cysteine + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51249", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130706", "l": "MHC class II antigen processing (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64658", "l": "(E)-sinapoyl-CoA + H(+) + NADPH => (E)-sinapaldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43269", "l": "a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GM2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71095", "l": "2 Na(+)(out) + pregnenolone sulfate(out) = 2 Na(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52825", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813626", "l": "LEAP2 binds bacteria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328037", "l": "Fibrillin-1 binds integrins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67578", "l": "[protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47839", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17075", "l": "CoA + cortisol 21-acetate => acetyl-CoA + cortisol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102966", "l": "arachidoyl-CoA:1-dodecanol O-acyltransferase activity", "d": ["Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663246", "l": "RORA, EP300 bind NPAS2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008043", "l": "MAPK8 phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031878", "l": "type 1 somatostatin receptor binding", "d": ["Binding to a type 1 somatostatin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75081", "l": "Formation of AT-AC B Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57301", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36428", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69416", "l": "H(+) + H2O2 + thiocyanate = H2O + hypothiocyanous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0016898", "l": "oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule."], "t": []}, {"i": "EC:1.1.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66432", "l": "H(+)(out) + L-galactose(out) = H(+)(in) + L-galactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27364", "l": "chloride + S-adenosyl-L-methionine <=> chloromethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41381", "l": "H(+) + NADH + O2 + toluene => 4-methylphenol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75856", "l": "Abortive Initiation Before Second Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15553", "l": "1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.57", "l": "\"inositol-1,4-bisphosphate 1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70292", "l": "3-(2-aminophenyl)-3-oxopropanal => H2O + quinolin-4-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49390", "l": "H(+) + UDP + validamycin A => UDP-alpha-D-glucose + validoxylamine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205306", "l": "Interaction of SHP1 and KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64695", "l": "isobutanol + NAD(+) <=> 2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893609", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27838", "l": "9H-carbazole + H(+) + NADH + O2 = 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022065", "l": "DSPGs are secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34720", "l": "15-methylhexadecasphing-4-enine 1-phosphate => (2E)-13-methyltetradecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001042", "l": "RNA polymerase I core binding", "d": ["Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17849", "l": "(3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.55", "l": "\"3-hydroxybutyryl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61168", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71050", "l": "glycine(in) + L-phenylalanine(out) <=> glycine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130731", "l": "Formation of COPII vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691174", "l": "RAC1 binds effectors at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102039", "l": "NADH-dependent peroxiredoxin activity", "d": ["Catalysis of the reaction: a hydroperoxide + H+ + NADH = an alcohol + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21463", "l": "benzoin <=> 2 benzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.19", "l": "\"cis-1,2-dihydrobenzene-1,2-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40181", "l": "(2E)-decenoyl-CoA + H2O2 => decanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.71", "l": "\"sortase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31207", "l": "FAD + H(+) + hexanoyl-CoA = (2E)-hexenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47949", "l": "H2O + thiamine phosphate => phosphate + thiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58884", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 = A + chloramphenicol + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.99.67", "l": "\"alpha-N-dichloroacetyl-p-aminophenylserinol N-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9833635", "l": "p-PKR dimer localizes to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73857", "l": "5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP => 5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14421", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide = 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": [], "t": []}, {"i": "EC:3.5.1.72", "l": "\"D-benzoylarginine-4-nitroanilide amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61043", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72574", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70387", "l": "3-oxosphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018676", "l": "(S)-limonene 7-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (4S)-perillyl alcohol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538822", "l": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73233", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+) => 2,4,6-trichlorophenol + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31578", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21640", "l": "NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.13", "l": "\"prephenate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205649", "l": "p62 links damaged mitochondria to LC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50668", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.344", "l": "\"type 2 galactoside alpha-(1,2)-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247915", "l": "GSH translocates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008995", "l": "ribonuclease E activity", "d": ["Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60924", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12767", "l": "acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11726", "l": "3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67348", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA = apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446372", "l": "Association of  PARVA with TESK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41028", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45109", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65921", "l": "L-kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.726079367374183", "identifiers": [{"i": "GO:0046912", "l": "acyltransferase activity, acyl groups converted into alkyl on transfer", "d": ["Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer."], "t": []}, {"i": "EC:2.3.3.-", "l": "\"Acyl groups converted into alkyl groups on transfer\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714691", "l": "RAC3 binds ER effectors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43106", "l": "A + an N-acyleicosasphing-4-enine + 2 H2O => AH2 + an N-acyleicosasphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654571", "l": "Activated FGFR1 binds FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795473", "l": "PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754554", "l": "SARS-COV 7a translocates to the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102998", "l": "4-sulfomuconolactone hydrolase activity", "d": ["Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O = maleylacetate + sulfite + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75079", "l": "Formation of AT-AC C complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784735", "l": "PCSK9:LDLR bind to Clathrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617087", "l": "CEBPA binds the promoter of the GFI1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12826", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine => [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47224", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74321", "l": "O-acetyl-(R)-carnitine(out) => O-acetyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18129", "l": "2-oxoaldehyde + H2O + NADP(+) = a 2-oxocarboxylate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.49", "l": "\"2-oxoaldehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691150", "l": "TFR2 dimer binds 2xholoTF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71704", "l": "taurocholate(out) => taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23781", "l": "H2O + oxaloacetate + propanoyl-CoA => (2S,3S)-2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029471", "l": "Hydrolysis of PC to PA by PLD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446364", "l": "Migfilin interacts with VASP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33311", "l": "2 A + hydroxylamine + NH4(+) = 2 AH2 + H(+) + H2O + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099580", "l": "monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential", "d": ["Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205319", "l": "Interaction of APS and p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31465", "l": "beta-D-glucosyl crocetin + UDP => crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332235", "l": "CBL binds TGFBR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66119", "l": "2-oxobutanoate + L-glutamine <=> (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015462", "l": "ABC-type protein transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21554", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781899", "l": "USP13 binds SIAH2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796647", "l": "TP53 stimulates CCNK expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49516", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.54", "l": "\"mRNA N(1)-methyladenine demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034568", "l": "isoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638845", "l": "CERK phosphorylates CERA to form C1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57619", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O <=> dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55484", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60106", "l": "(E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein] => H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12733", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": [], "t": []}, {"i": "EC:2.4.2.19", "l": "\"nicotinate-nucleotide diphosphorylase (carboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19737", "l": "4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.94", "l": "\"gamma-glutamyl-gamma-aminobutyrate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69512", "l": "H2O + N-acetyl-D-galactosamine + O2 = H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25252", "l": "H(+) + 2 pyruvate <=> (2S)-2-acetolactate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74860", "l": "dopamine + formaldehyde => H2O + norsalsolinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11038", "l": "a quaternary ammonium(in) + ADP + H(+) + phosphate => a quaternary ammonium(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32663", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine = 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.243", "l": "\"2-ketoarginine methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21650", "l": "3-phenylpyruvate + CO2 + H2O => H(+) + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61722", "l": "a 3-dehydro-D-guloside + H(+) + NADH => a D-guloside + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33860", "l": "(2S-3S)-versiconal hemiacetal => H2O + versicolorin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59820", "l": "2 ATP = adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69282", "l": "3-hydroxypropyl isothiocyanate + sulfate => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49579", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866851", "l": "CFTR transits to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53481", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015304", "l": "glucose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047206", "l": "UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA(Ala) = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67066", "l": "A + asnovolin A => AH2 + asnovolin K", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21735", "l": "chorismate + L-glutamine <=> anthranilate + H(+) + L-glutamate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59274", "l": "D-cysteine => L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21098", "l": "3-dehydroshikimate + H2O => 3-dehydroquinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018814", "l": "RHOT1 hydrolyzes GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004430", "l": "1-phosphatidylinositol 4-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74071", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54907", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH <=> (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602242", "l": "Defective CYP2U1 does not omega-hydroxylate ARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14151", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP => luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928646", "l": "EPHAs bind EFNAs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339711", "l": "misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987120", "l": "JAK1 binds IFNLR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985943", "l": "p-Y701-STAT1 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.1", "l": "\"exoribonuclease II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177934", "l": "EGFR autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093331", "l": "Ras:GTP binds p120-RasGAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050290", "l": "sphingomyelin phosphodiesterase D activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14545", "l": "H2O + nicotinamide = NH4(+) + nicotinate", "d": [], "t": []}, {"i": "EC:3.5.1.19", "l": "\"nicotinamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42910", "l": "5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1939) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2870221", "l": "E-selectin binds E-selectin ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22327", "l": "H2O + leukotriene A4 <=> leukotriene B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16028", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA <=> an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16748", "l": "AH2 + O2 + phylloquinone <=> 2,3-epoxyphylloquinone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-990489", "l": "Kinesin-13 is a dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618582", "l": "CEBPA binds MYC gene:E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44206", "l": "2-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 2-hydroxyhexadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29909", "l": "glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-rac-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12729", "l": "lutein = (3R,3'S)-zeaxanthin", "d": [], "t": []}, {"i": "EC:5.3.3.22", "l": "\"lutein isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48263", "l": "a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421831", "l": "trans-Golgi Network Coat Assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25361", "l": "biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35683", "l": "hexadecasphinganine + NADP(+) = 3-oxohexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23066", "l": "an aldehyde + FMN + 2 H(+) + H2O + sulfite => an alkanesulfonate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61961", "l": "a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16128", "l": "ATP + D-fructose <=> ADP + D-fructose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41815", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH <=> butanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69737", "l": "2-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27777", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67678", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61389", "l": "ATP + biotin(in) + H2O => ADP + biotin(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.5.-", "l": "\"With a quinone or related compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784598", "l": "NPPA(124-151) binds NPR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47413", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14750", "l": "1-hydroxy-2-naphthoate + O2 => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30222", "l": "dimethyl sulfoxide + H2O + NAD(+) <=> dimethyl sulfone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35241", "l": "tetracycline(out) => tetracycline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047487", "l": "oligogalacturonide lyase activity", "d": ["Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49223", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP <=> CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41748", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17870", "l": "5,6,7,8-tetrahydropteridine + NAD(+) => 6,7-dihydropteridine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47186", "l": "7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417898", "l": "P2Y4 receptor can bind to UTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77081", "l": "Formation of the CE:GMP intermediate complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68892", "l": "3-methoxybenzoate + ATP + H(+) + NADPH = 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803801", "l": "TP53 in complex with ZNF385A binds the CDKN1A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54135", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77585", "l": "1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41508", "l": "L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052825", "l": "inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046558", "l": "arabinan endo-1,5-alpha-L-arabinosidase activity", "d": ["Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25333", "l": "(R)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39878", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389350", "l": "Activation of Cdc42 by pVav1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41941", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034785", "l": "salicylate 5-hydroxylase activity", "d": ["Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237119", "l": "Acireductone is oxidized to MOB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795153", "l": "Basolateral excretion of oxo-Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42416", "l": "a ubiquinone + L-proline = (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.339", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13254", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24256", "l": "ATP + kanamycin A = ADP + H(+) + kanamycin 3'-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.95", "l": "\"kanamycin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801637", "l": "TP53 stimulates PLK2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15945", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] = H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73785", "l": "diphosphate + echinulin => dimethylallyl diphosphate + tardioxopiperazine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373727", "l": "Nephrin binds CD2AP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69340", "l": "(E)-prop-1-en-1-SO-peroxol = (Z)-propanethial S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63068", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA = 2 CO2 + 3 CoA + triacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018613", "l": "9-fluorenone dioxygenase activity", "d": ["Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65333", "l": "H(+) + NADPH + O2 + verruculide A => chrodrimanin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38166", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48592", "l": "a quinone + formate + H(+) = a quinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047299", "l": "tryptophan-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167217", "l": "Phospho-Shc dissociates from the TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654533", "l": "KRAS4B recycles to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27692", "l": "ADP + dGTP => ATP + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73191", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA = (2R,3S,11R)-acetylaszonalenin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22447", "l": "(E)-coniferol + NADP(+) <=> (E)-coniferaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047051", "l": "D-lactate dehydrogenase (cytochrome c-553) activity", "d": ["Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67062", "l": "asnovolin K + S-adenosyl-L-homocysteine => asnovolin I + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.13", "l": "\"retroviral ribonuclease H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029454", "l": "Autophosphorylation of PAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030782", "l": "(S)-tetrahydroprotoberberine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22154", "l": "a ubiquinol + D-glucono-1,5-lactone => a ubiquinone + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694281", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54814", "l": "AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + ATP + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16424", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164832", "l": "ATPase synthesizes ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20510", "l": "ATP + viomycin => ADP + H(+) + O-phosphoviomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445700", "l": "Myosin Binds ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64251", "l": "decanoyl-CoA + glycine <=> CoA + H(+) + N-decanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707505", "l": "Hemes bind to CLEC1B dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033898", "l": "Bacillus subtilis ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140338", "l": "sphingomyelin transfer activity", "d": ["Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72896", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine => 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374173", "l": "AGT(34-41) binds to AGTR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68329", "l": "(R)-4'-phosphopantetheine + H2O => (R)-pantetheine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12434", "l": "H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine => L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641147", "l": "DACT1 binds DVL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50823", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> H(+) + NADPH + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19315", "l": "an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29986", "l": "cytidine(in) + H(+)(in) <=> cytidine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32671", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.176", "l": "\"UDP-N-acetylglucosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77401", "l": "(2S)-2-hydroxyhexanenitrile => hydrogen cyanide + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54181", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) => a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428625", "l": "Vesicular inhibitory amino acid transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033461", "l": "GGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200646", "l": "Cytosolic folate export across the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34780", "l": "a 3alpha-hydroxysteroid + NAD(+) => a 3-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52646", "l": "5-phospho-D-xylonate + H(+) => D-xylono-1,4-lactone 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72333", "l": "3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74176", "l": "a secondary alkyl amine + H2O + NAD(+) => a ketone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21149", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose => 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56090", "l": "a globoside DSGG + CMP + H(+) => a globoside MSGG + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74716", "l": "Insulin binds the insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047238", "l": "glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176318", "l": "Loading of claspin onto DNA during replication origin firing (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2169046", "l": "Degradation of TGF-beta receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873794", "l": "PCTP binds PC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12420", "l": "ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.144", "l": "\"tagatose-6-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375154", "l": "Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16179", "l": "2 H(+) + NADH + retinoate => H2O + NAD(+) + retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70638", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62372", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.399278032977378", "identifiers": [{"i": "GO:0005262", "l": "calcium channel activity", "d": ["Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791118", "l": "Expression of ASNS (Asparagine Synthetase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40708", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72047", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline = AH2 + fusahexin + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0052842", "l": "inositol diphosphate pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18122", "l": "an S-substituted L-cysteine + H2O => a thiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36544", "l": "H2O + mycothiol S-conjugate => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139898", "l": "Caspase-8 activates BID by cleavage (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39644", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH => (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399997", "l": "AKT1 E17K mutant translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052798", "l": "beta-galactoside alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805640", "l": "AKT phosphorylates KAT6A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69348", "l": "S-1-propenyl-L-cysteine sulfoxide = (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16950", "l": "myo-inositol + NAD(+) => H(+) + NADH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12515", "l": "D-aspartate + H2O + O2 <=> H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692134", "l": "Expression of FGF9 in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21125", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52697", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11960", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.17", "l": "\"succinyldiaminopimelate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.197", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60836", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45403", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11430", "l": "D-glucono-1,5-lactone + H2O2 => beta-D-glucose + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58632", "l": "N-tetradecanoyl-(2S)-hydroxyglycine = glyoxylate + tetradecamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183067", "l": "Localization of CBL:GRB2 to the membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13357", "l": "3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.59", "l": "\"3-hydroxypropionate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49029", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69015", "l": "5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18058", "l": "O2 + Watasenia luciferin => CO2 + hnu + oxidized Watasenia luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32709", "l": "(2R,4S)-bornyl diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018575", "l": "chlorocatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59413", "l": "2-oxosuccinamate + H2O => NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901584", "l": "tetrapeptide transmembrane transporter activity", "d": ["Enables the transfer of tetrapeptide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043785", "l": "cinnamoyl-CoA:phenyllactate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64654", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => (E)-4-coumaraldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668714", "l": "RAC1:GTP binds NOX1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675790", "l": "MTORC1 dissociates from ULK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134962", "l": "DHX36 binds DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34725", "l": "15-methylhexadecasphing-4-enine + phosphate => 15-methylhexadecasphing-4-enine 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77735", "l": "2 H2O + ITP = 2 H(+) + IMP + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30240", "l": "n a quinone + n H(+) + n hydrogen sulfide => n a quinol + n sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0045703", "l": "ketoreductase activity", "d": ["Catalysis of the reduction of a ketone group to form the corresponding alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683774", "l": "p-T68-CHEK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734597", "l": "MEF2C binds the SMYD1 (BOP) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450533", "l": "PKCdelta phosphorylates HuR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24610", "l": "2,5-dioxopentanoate + CO2 + H2O => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31997", "l": "7-epi-sesquithujene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18075", "l": "AH2 + orotate => (S)-dihydroorotate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76736", "l": "decane + O2 + reduced [NADPH--hemoprotein reductase] => 3-decanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39178", "l": "(3R)-hydroxyeicosanoyl-CoA <=> (2E)-eicosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418925", "l": "ADORA2A,B bind Ade-Rib (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681514", "l": "TMPRSS2 binds TMPRSS2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848713", "l": "PTK6 binds BCAR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70117", "l": "6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.-", "l": "\"Amidinotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57585", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15793", "l": "bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27861", "l": "2',3'-cyclophospho-GMP + H2O <=> 3'-GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211874", "l": "CYP2S1 4-hydroxylates atRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044685", "l": "tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858482", "l": "DVL is recruited to the receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031836", "l": "neuromedin K receptor binding", "d": ["Binding to a neuromedin K receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13446", "l": "(R)-pantetheine + H2O => (R)-pantothenate + cysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41194", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22608", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": [], "t": []}, {"i": "EC:3.5.1.18", "l": "\"succinyl-diaminopimelate desuccinylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33222", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28078", "l": "2-hydroxyethylphosphonate + NAD(+) = H(+) + NADH + phosphonoacetaldehyde", "d": [], "t": []}, {"i": "EC:1.1.1.309", "l": "\"phosphonoacetaldehyde reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15087", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31773", "l": "11-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33991", "l": "(2E,6E)-farnesyl diphosphate = alpha-copaene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.133", "l": "\"alpha-copaene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13641", "l": "H(+) + methane + NADPH + O2 = H2O + methanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67939", "l": "a 2-hydroxy carboxylate + O2 <=> a 2-oxocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35634", "l": "cyanidin + UDP-alpha-D-galactose <=> cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388828", "l": "PD-1 binds B7DC and B7H1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10855", "l": "dimethylallyl diphosphate + leachianone G <=> diphosphate + sophoraflavanone G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40855", "l": "FAD + H(+) + undecanoyl-CoA = FADH2 + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64560", "l": "butan-2-ol + NAD(+) = butan-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20583", "l": "2 H(+) + hydroxylamine + NADH => H2O + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047775", "l": "citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047465", "l": "N-acylglucosamine-6-phosphate 2-epimerase activity", "d": ["Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59462", "l": "H(+) + hexadecanal + NADPH => hexadecan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58331", "l": "(Z)-non-6-en-1-ol + NADP(+) <=> (Z)-non-6-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12483", "l": "5-aminolevulinate + pyruvate <=> 4,5-dioxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707523", "l": "Hemes bind to BACH1:MAFK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42946", "l": "5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(40) in tRNA precursor + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25292", "l": "acetaldehyde + H(+) + NADH => ethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43168", "l": "adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.33", "l": "\"tRNA(adenine(34)) deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71699", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) = H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63573", "l": "H2O + neurotensin-(1-8) => L-arginine + neurotensin-(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830969", "l": "EYA1, PAX2, and HOX11 paralog bind the GDNF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55284", "l": "all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27279", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57781", "l": "2-chloro-4-nitrotoluene + NADH + O2 => 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35796", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine => H(+) + kanamycin A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21993", "l": "acetyl-CoA + L-lysyl-[histone] => CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26097", "l": "(4R)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098769", "l": "TIMP family protein binding", "d": ["Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38329", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198611", "l": "AKT phosphorylates IKKalpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42491", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III <=> 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38474", "l": "L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55987", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose <=> (R)-prunasin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56555", "l": "ATP + L-threonyl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31896", "l": "(2E,6E)-farnesyl diphosphate => alpha-humulene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64884", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP = (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59444", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A = 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.4", "l": "\"ABC-type teichoic-acid transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49617", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) => 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54156", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49328", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50212", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48992", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 = 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.212", "l": "\"1,3,7-trimethyluric acid 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13312", "l": "H2O + NAD(+) + vanillin <=> 2 H(+) + NADH + vanillate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69687", "l": "genistein 7-O-beta-D-glucoside + H2O = beta-D-glucose + genistein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37258", "l": "A + D-asparagine + H2O <=> 2-oxosuccinamate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031758", "l": "Edg-5 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-5 sphingosine 1-phosphate receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.165", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69462", "l": "[thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine => [thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46739", "l": "H2O + monoacyl-sn-glycero-3-phosphate <=> a monoacylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57315", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine <=> cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76016", "l": "(3R)-hydroxybutanoate trimer + H2O => (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12056", "l": "D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.72", "l": "\"erythrose-4-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51871", "l": "dimethylallyl diphosphate + umbelliferone <=> demethylsuberosin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13507", "l": "betaine aldehyde + H2O2 => choline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15262", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66126", "l": "(2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate => 2-oxobutanoate + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13410", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) => 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22117", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44663", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41248", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690702", "l": "LYN phosphorylates CD22 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102953", "l": "hypoglycin A gamma-glutamyl transpeptidase activity", "d": ["Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667914", "l": "ALK binds ligand midkine (MDK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65715", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690669", "l": "CD22 binds itself to form homo-oligomers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16053", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.187", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49708", "l": "nocardicin G + S-adenosyl-L-methionine = H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080150", "l": "S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity", "d": ["Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64725", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48048", "l": "a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GM2 (d18:1(4E)) + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18560", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA <=> 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39029", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63147", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine <=> (15Z)-tetracosenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27714", "l": "GMP + H2O = guanosine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430308", "l": "PARVB interacts with Alpha-actinin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64923", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110360", "l": "Recruitment of POLB to the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59596", "l": "H2O + kynuramine + O2 = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52823", "l": "L-serine + succinyl-CoA <=> CoA + O-succinyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65383", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046608", "l": "carotenoid isomerase activity", "d": ["Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52785", "l": "2-sulfenohercynine + AH2 + H(+) => A + ergothioneine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019179", "l": "dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity", "d": ["Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718020", "l": "PTGFR binds PTGFR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77244", "l": "H(+) + hnu + octadecanoate => CO2 + heptadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382058", "l": "Nck binds to the active PDGF receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39749", "l": "cholesterol(out) => cholesterol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17183", "l": "a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu => a long-chain fatty aldehyde + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0033612", "l": "receptor serine/threonine kinase binding", "d": ["Binding to a receptor that possesses protein serine/threonine kinase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046932", "l": "sodium-transporting ATP synthase activity, rotational mechanism", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.617478300466217", "identifiers": [{"i": "GO:0052689", "l": "carboxylic ester hydrolase activity", "d": ["Catalysis of the hydrolysis of a carboxylic ester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700120", "l": "PTN and MDK bind to PTPRZ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68386", "l": "(2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052753", "l": "propan-2-ol:coenzyme F420 oxidoreductase activity", "d": ["Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43982", "l": "15-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38776", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34167", "l": "2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.19", "l": "\"2,6-dihydroxypseudooxynicotine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49250", "l": "galactitol 1-phosphate(in) + L-histidyl-[protein] => galactitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37197", "l": "1-octadecanoyl-sn-glycero-3-phosphate + CoA => octadecanoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58607", "l": "FAD + 2 H(+) + NADH + O2 <=> FADH2-C4alpha-hydroperoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160931", "l": "Disassembly of tight junctions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57306", "l": "glycolate + GMP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24763", "l": "H(+) + L-dopa + NADH <=> 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29419", "l": "H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879942", "l": "The receptor is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38731", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45475", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008983", "l": "protein-glutamate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008779", "l": "acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388605", "l": "POMC(138-176) binds MC2R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30837", "l": "NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28248", "l": "(R)-4-phosphopantoate + ADP + H(+) => (R)-pantoate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69766", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) <=> a medium chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51462", "l": "(9Z)-octadecenoate + L-glutamate => H2O + N-(9Z-octadecenoyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61428", "l": "cis-trans-nepetalactol + NAD(+) = cis-trans-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875183", "l": "CBL monoubiquitinates activated MET (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430190", "l": "p-SLP-76 binds NCK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733744", "l": "MESP1 binds the NKX2-5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874198", "l": "CREB3L2 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68812", "l": "(2Z,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25753", "l": "H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": [], "t": []}, {"i": "EC:5.3.3.13", "l": "\"polyenoic fatty acid isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803391", "l": "TP53 binds the PCBP4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21951", "l": "formamide + H2O <=> formate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56959", "l": "ITP + pyruvate <=> H(+) + IDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786190", "l": "CMBL hydrolyses OM to OLMS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0017076", "l": "purine nucleotide binding", "d": ["Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66453", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) => 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627350", "l": "SMAC (DIABLO) binds XIAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877281", "l": "PIAS1 binds p-STAT1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390593", "l": "ATP Hydrolysis By Myosin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75079", "l": "Formation of AT-AC C complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70142", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043908", "l": "Ser(Gly)-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24463", "l": "H(+) + malonyl-[ACP] <=> acetyl-[ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34918", "l": "D-galactose(in) <=> D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749609", "l": "BCHE hydrolyzes ASA- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.6", "l": "\"channel-conductance-controlling ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140691", "l": "RNA folding chaperone", "d": ["Binding to an RNA or an RNA-containing complex to assist the folding process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621571", "l": "CD209 binds ICAM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48123", "l": "a ganglioside GD3 + H2O <=> a ganglioside GM3 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34012", "l": "5-dehydroepisterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35106", "l": "fusidate(in) <=> fusidate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27876", "l": "pyruvate + salicylate => isochorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61938", "l": "ADP + cycloheximide(out) + H(+) + phosphate => ATP + cycloheximide(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052806", "l": "sulfite reductase (coenzyme F420) activity", "d": ["Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56473", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68519", "l": "(2Z,6Z)-farnesyl diphosphate <=> beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748996", "l": "GST dimers cleave AZA to 6MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696357", "l": "LAIR2 binds collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44798", "l": "H(+) + menaquinol-13 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-13 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190790", "l": "Assembly of gap junction plaques (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696131", "l": "AOC1 deaminates Hist (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48684", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": [], "t": []}, {"i": "EC:3.5.1.130", "l": "\"[amino group carrier protein]-lysine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23137", "l": "a primary amine + S-adenosyl-L-methionine => a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19587", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => lithocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029456", "l": "RAC1 and CDC42 activate PAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428625", "l": "Vesicular inhibitory amino acid transport (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114256", "l": "CYCS:APAF1 binds procaspase-9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964588", "l": "CCNA2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112385", "l": "Addition of nucleotides leads to transcript elongation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37230", "l": "(E,E)-sorbate + H(+) <=> (E)-1,3-pentadiene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22711", "l": "H2O + S-acylglutathione <=> a carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805061", "l": "CK2 binds FACT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37102", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085027", "l": "Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400204", "l": "PPARA binds RXRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042608", "l": "T cell receptor binding", "d": ["Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709179", "l": "DPP4 binds DPP4 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53336", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67533", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50349", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16626", "l": "acetyl-CoA + hydrogen sulfide => CoA + thioacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799733", "l": "Semiquinone reacts with oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12070", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] => apo-[ACP] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380930", "l": "Phosphorylated AMPK binds AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664268", "l": "Opsonized leishmania amastigote binds FCGR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0008187", "l": "poly-pyrimidine tract binding", "d": ["Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035374", "l": "chondroitin sulfate binding", "d": ["Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42792", "l": "cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166219", "l": "FA anion picks up a proton (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52557", "l": "3-dehydro-D-erythronate + ATP => 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68970", "l": "H2O2 + phenylglyoxylate => mandelate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59964", "l": "L-seryl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n4", "l": "\"ankyrin-repeat-histidine dioxagenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730842", "l": "PI3K associates with phosphorylated GAB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52893", "l": "H2O + NADP(+) + nitrosobenzene => H(+) + NADPH + nitrobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164505", "l": "Synthesis of full-length duplex viral DNA with a discontinuous plus strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939205", "l": "ESTG translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001671", "l": "ATPase activator activity", "d": ["Binds to and increases the activity of an ATP hydrolysis activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70354", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13024", "l": "H(+) + NADH + O2 + vanillate <=> 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22289", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794353", "l": "NRXNs binds MUNC18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102853", "l": "1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373733", "l": "Neurofascin binds contactin-1:CASPR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49228", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) = diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": [], "t": []}, {"i": "EC:2.5.1.133", "l": "\"bacteriochlorophyll a synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140761", "l": "sequestered tissue factor -> tissue factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38728", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379887", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25993", "l": "(2E,6E)-farnesyl diphosphate => (+)-epi-isozizaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852200", "l": "Inactivation of LCK by PTPN22 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54686", "l": "(-)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51977", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53467", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62424", "l": "(E)-caffeoyl-CoA + H2O = 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45437", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54610", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60170", "l": "a fatty acyl monophosphate + ADP => a fatty acid + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41618", "l": "D-ribose 5-phosphate + phosphate => D-ribose 2,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19377", "l": "NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15464", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39993", "l": "CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine => (4R)-hydroxyeicosasphinganine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787447", "l": "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15509", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.144", "l": "\"beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12913", "l": "(R)-lipoate + ATP + H(+) = (R)-lipoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18692", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15789", "l": "L-xylose + NADP(+) = H(+) + L-xylono-1,4-lactone + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.113", "l": "\"L-xylose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514865", "l": "cGMP dissociates from CNG channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33387", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.16", "l": "\"versatile peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52741", "l": "glyphosate + H2O + O2 => aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016861", "l": "PTCRA gene expression is stimulated by NOTCH3 and inhibited by IK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66241", "l": "ATP + CoA + IC-asc-C9 => AMP + diphosphate + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.101", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190698", "l": "Transport of connexins to the ER-Golgi intermediate compartment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63106", "l": "16-hydroxy-ilicicolin A epoxide + H2O + NADP(+) => H(+) + ilicicolin A epoxide + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64242", "l": "CoA + H(+) + N-octanoylglycine => glycine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604929", "l": "Activated protein C binds Protein S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77578", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecylglycerol <=> 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047058", "l": "vitamin-K-epoxide reductase (warfarin-insensitive) activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20358", "l": "3-phenylpropanoate + H(+) + NADH + O2 => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0035368", "l": "selenocysteine insertion sequence binding", "d": ["Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44218", "l": "12-hydroxyoctadecanoyl-CoA + AMP + diphosphate => 12-hydroxyoctadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23817", "l": "2-oxoglutarate + putrescine => 4-aminobutanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69780", "l": "2-oxindole-3-acetate + succinyl-CoA => (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10757", "l": "ATP + phosphate + pyruvate => AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.6", "l": "\"chalcone isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62988", "l": "dodecanamide + H2O = dodecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13599", "l": "agmatine + urea => 1,4-diguanidinobutane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65522", "l": "all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376122", "l": "DSCAM/DSCAML1 homodimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73729", "l": "Formation of SL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6802973", "l": "PLK3 phosphorylates CDC25C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29132", "l": "menaquinol-8 + nitrate => H2O + menaquinone-8 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5228992", "l": "ROCK1,ROCK2 are activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235070", "l": "Expression of Erythropoietin (EPO) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37791", "l": "aclacinomycin A + O2 = aclacinomycin Y + H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.14", "l": "\"aclacinomycin-A oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12842", "l": "pyridoxamine + pyruvate => L-alanine + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49101", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622415", "l": "RIP2 binds NEMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803890", "l": "SFN dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66499", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40614", "l": "H2O + trihexanoylglycerol <=> 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13603", "l": "4-oxo-L-proline + H(+) + NADH => cis-4-hydroxy-L-proline + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35324", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853444", "l": "AURKA phosphorylates PHLDA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29423", "l": "ATP + diphosphate = ADP + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30053", "l": "fluoride + glycolate + H(+) => fluoroacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11176", "l": "kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.230", "l": "\"kojibiose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2214324", "l": "Collagen type VII dimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62014", "l": "5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70979", "l": "4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047253", "l": "alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68485", "l": "(2R)-2-hydroperoxydodecanoate + H(+) => CO2 + H2O + undecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68820", "l": "(2Z,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59080", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53428", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62824", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26004", "l": "D-xylulose 5-phosphate + H(+) + NADH => D-arabinitol 1-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45076", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68390", "l": "2 H2O + 2 indole-5,6-quinone-2-carboxylate => 2 5,6-dihydroxyindole-2-carboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27896", "l": "cytidine + phosphate => 3'-CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668404", "l": "TNFA binds TNFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003961", "l": "O-acetylhomoserine aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66024", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617828", "l": "TRIP11:IFT20 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72728", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) => UDP-alpha-D-glucuronate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34834", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate <=> N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68788", "l": "(2Z,6Z)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16153", "l": "an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44053", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67635", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] <=> a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768999", "l": "NOTCH1 PEST domain mutants bind JAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31602", "l": "FMNH2 + NADH + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33639", "l": "ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102624", "l": "scutellarein 7-methyl ether 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine = ladanein + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163310", "l": "TFAM binds to mitochondrial promoters (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38664", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985594", "l": "MYO9B inactivates RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23647", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.917179239854292", "identifiers": [{"i": "GO:0016667", "l": "oxidoreductase activity, acting on a sulfur group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57168", "l": "(R)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102296", "l": "4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity", "d": ["Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982017", "l": "Active G alpha (q) binds RGS proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72160", "l": "glutarate(in) + taurocholate(out) => glutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21234", "l": "NH4(+) + trans-urocanate => L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30212", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide => 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873919", "l": "Phosphorylation of JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941895", "l": "Formation of CDK4/6:CCND complexes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55967", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265456", "l": "NPC1L1 binds ezetimibe (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13765", "l": "bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865275", "l": "PDGF-BB clevage by Furin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58636", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769307", "l": "NPAS4 represses INS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163310", "l": "TFAM binds to mitochondrial promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382061", "l": "Extracellular processing of novel PDGFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004783", "l": "sulfite reductase (NADPH) activity", "d": ["Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18281", "l": "NAD(+) + succinate = fumarate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.6", "l": "\"fumarate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102833", "l": "sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity", "d": ["Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol = D-galactosylononitol + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428123", "l": "KDSR reduces 3-ketosphingoid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17570", "l": "(R)-reticuline + NADP(+) => 1,2-dehydroreticuline + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373087", "l": "Receptor CCR6 binds CCL20 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55087", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O <=> (3R)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55699", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O <=> an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77476", "l": "acetyl-CoA + tetrahydroanabasine => ammodendrine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701485", "l": "Active ALK binds JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802165", "l": "TP53 binds the PLK3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22110", "l": "2-oxobutanoate + NH4(+) => L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40262", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3S)-hydroxyhexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712199", "l": "cAMP binds the olfactory CNG channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617815", "l": "BBSome binds RAB3IP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35051", "l": "N,N'-diacetylchitobiose(out) = N,N'-diacetylchitobiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17604", "l": "ATP + D-ribulose <=> ADP + D-ribulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14409", "l": "cysteamine + O2 = H(+) + hypotaurine", "d": [], "t": []}, {"i": "EC:1.13.11.19", "l": "\"cysteamine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160081", "l": "iodide channel activity", "d": ["Enables the facilitated diffusion of a iodide (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}, {"i": "RHEA:66324", "l": "iodide(out) = iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35349", "l": "(2E)-octadecenoyl-CoA + H2O => 3-hydroxyoctadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18041", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] = 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.7.7.1", "l": "\"ferredoxin--nitrite reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.157", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265456", "l": "NPC1L1 binds ezetimibe (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56204", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51680", "l": "(2E,6E)-farnesol + CTP = (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24340", "l": "(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.4", "l": "\"(R,R)-butanediol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46998", "l": "6-hydroxypseudooxynicotine => 6-hydroxy-N-methylmyosmine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140070", "l": "hydrogen peroxide channel activity", "d": ["Enables the transfer of hydrogen peroxide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34474", "l": "NAD(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445064", "l": "Activation of Rac1 by VAV2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35506", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34946", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) <=> arbutin 6-phosphate(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050611", "l": "arsenate reductase (azurin) activity", "d": ["Catalysis of the reaction: H2O + arsenite + 2 oxidized azurin = 2 H+ + 2 reduced azurin + arsenate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10098", "l": "an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine => a fatty acyl-[ACP] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34307", "l": "4-nitrocatechol + NADPH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59161", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48640", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37407", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66009", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754130", "l": "CDK4 inhibitors bind CDK4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782820", "l": "USP17 deubiquitinates SUDS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22474", "l": "(R)-4'-phosphopantetheine + ADP + H(+) => (R)-pantetheine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030116", "l": "glial cell-derived neurotrophic factor receptor binding", "d": ["A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429815", "l": "Formation Of Bloc-1 Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18085", "l": "coenzyme B + coenzyme M + methanophenazine = coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": [], "t": []}, {"i": "EC:1.8.98.1", "l": "\"dihydromethanophenazine:CoB--CoM heterodisulfide reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874789", "l": "TFAP2C homodimer binds the EGFR gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62725", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide C + FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008705", "l": "methionine synthase activity", "d": ["Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25180", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.167", "l": "\"baicalin-beta-D-glucuronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202717", "l": "Heterodimerization of CEACAMs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669024", "l": "CD70 binds CD27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59658", "l": "D-cellotriono-1,5-lactone + H2O2 => D-cellotriose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48485", "l": "a propanoate ester + H2O => an aliphatic alcohol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30114", "l": "Fe(III)-enterobactin + H(+) + 3 H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354124", "l": "Phosphorylation of pPTK2 by SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18343", "l": "D-xylonate + H(+) => D-xylono-1,4-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029690", "l": "Caspase-6 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14710", "l": "a 3-oxo-Delta(5)-steroid => a 3-oxo-Delta(4)-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450550", "l": "PKCalpha phosphorylates HuR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57991", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75081", "l": "32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18690", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341294", "l": "Superoxide reduces cytochrome c (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21492", "l": "2,3-dihydroxybenzoate + H(+) = catechol + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.46", "l": "\"o-pyrocatechuate decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10159", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34751", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine = ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75945", "l": "3-guanidinopropanoate + L-ornithine => beta-alanine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60825", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate => 2 AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71703", "l": "taurocholate(out) = taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632646", "l": "SMURF1/2 bind PTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44861", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA => CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50536", "l": "prostaglandin E2 = H2O + prostaglandin A2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51108", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68332", "l": "(R)-4'-phosphopantothenate + H2O = (R)-pantothenate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42075", "l": "(4Z)-2-oxohept-4-enedioate + H2O <=> (4S)-4-hydroxy-2-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47493", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56733", "l": "4,4-dihydroxy-all-trans-beta-carotene => echinenone + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12957", "l": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.6", "l": "\"acetylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52847", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675417", "l": "PEBP1 binds activated RAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0046974", "l": "histone H3K9 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209828", "l": "Tryptophan is hydroxylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350475", "l": "FLW:MBS complex dephosphorylates SQH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:0016837", "l": "carbon-oxygen lyase activity, acting on polysaccharides", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide."], "t": []}, {"i": "EC:4.2.2.-", "l": "\"Acting on polysaccharides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913446", "l": "Interleukin-5 is a homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59671", "l": "D-cellohexaose + O2 <=> D-cellohexaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76027", "l": "(S)-reticuline + 2-oxoglutarate + O2 = (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26523", "l": "(2S,3S)-2-methylcitrate => 2-methyl-trans-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58602", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56851", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine <=> H(+) + reumycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49424", "l": "ATP + validone = ADP + H(+) + validone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27291", "l": "A + formate + H(+) => AH2 + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40819", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73800", "l": "SAICAR => AICAR + Fumarate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.130", "l": "\"3-dehydro-L-gulonate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202692", "l": "PIP3 binds to RhoA and activates it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726509", "l": "NR3C2 binds fludrocortisone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70211", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose = (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49173", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27348", "l": "FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38094", "l": "delta-tocotrienol + S-adenosyl-L-methionine <=> beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72637", "l": "1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16371", "l": "H(+) + NADH + pyruvate => (R)-lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0015665", "l": "alcohol transmembrane transporter activity", "d": ["Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53693", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O => H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34756", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine => D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.170170386724372", "identifiers": [{"i": "GO:0099094", "l": "ligand-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62205", "l": "1-propanol + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419011", "l": "Transhomodimerization of Nectins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20235", "l": "a 7-oxosteroid + H(+) + NADPH => a 7beta-hydroxysteroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760402", "l": "ILF3 binds HOXC8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70161", "l": "folate(out) + H(+)(out) => folate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77583", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033458", "l": "GAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23594", "l": "D-glyceraldehyde + H(+) + NADPH => glycerol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656070", "l": "FGFBPs bind FGFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68416", "l": "cis-(homo)2aconitate + H2O = (2R,3S)-iso(homo)2citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158849", "l": "Phenol can form a sulfate conjugate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40794", "l": "H2O + hexacosanoyl-CoA <=> CoA + H(+) + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170964", "l": "FRS2 binds to active TrkA receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944240", "l": "Association of procollagen type III (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950183", "l": "IL12B binds IL23A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25485", "l": "(2E)-geranyl diphosphate => (1S,4R)-camphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25407", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38100", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate => a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34824", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + curcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57744", "l": "[protein]-disulfide + phylloquinol = [protein]-dithiol + phylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052848", "l": "inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "d": ["Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627089", "l": "CASP9 is phosphorylated at T412 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22037", "l": "[phosphate](n) + D-glucose => [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30756", "l": "ATP + carbamate => ADP + carbamoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166387", "l": "The FA anion diffuses away laterally from UCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102375", "l": "11-oxo-beta-amyrin 30-oxidase activity", "d": ["Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ = glycyrrhetinic acid + 3 NADP + 4 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16231", "l": "a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202307", "l": "Change of PKC theta conformation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76502", "l": "N-acetyl-D-glutamate <=> N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851908", "l": "Activated MET binds GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68636", "l": "(2E)-geranyl diphosphate = diphosphate + sabinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10623", "l": "(E)-cinnamaldehyde + CoA + NADP(+) <=> (E)-cinnamoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373736", "l": "Shootin-1 links L1 and retrograde actin flow (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65204", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O = (R)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14519", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => (E)-feruloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46648", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA = androst-4-ene-3,17-dione + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018677", "l": "pentachlorophenol monooxygenase activity", "d": ["Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.8", "l": "\"clostripain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18861", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42985", "l": "(+)-copalyl diphosphate => diphosphate + pimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732527", "l": "FFAR1 binds rosiglitazone (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58542", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-dodecanoylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13010", "l": "H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.61", "l": "\"caspase-8\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42550", "l": "pseudouridine(746) in 23S rRNA => uridine(746) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74061", "l": "beta-alanine(in) + L-alanine(out) => beta-alanine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52238", "l": "3 A + Fe(2+) + 3 H2O + mycobilin b => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21461", "l": "benzoin => 2 benzaldehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1214188", "l": "PRDM9 trimethylates histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61809", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP => AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77608", "l": "2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) => 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60295", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165195", "l": "GTP loading by Rheb (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34480", "l": "(1R,2R,3R)-prephytoene diphosphate => 15-cis-phytoene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43362", "l": "an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP => an N-acylsphinganine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32860", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676160", "l": "AAMP binds NOD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71510", "l": "(+)-alpha-tocopherol(out) <=> (+)-alpha-tocopherol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.1.-", "l": "\"Hydron translocation or charge separation linked to oxidoreductase reactions\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23936", "l": "D-gluconate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44674", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44956", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15550", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373047", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694723", "l": "Uncoating of SARS-CoV-2 Genome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514891", "l": "SLC24A1 exchanges 4Na+ for Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72383", "l": "Na(+)(out) + urate(in) = Na(+)(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76075", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) = a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27690", "l": "ATP + dGDP = ADP + dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63067", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + tetraacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53619", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-isoafricanol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25397", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72275", "l": "oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805943", "l": "S100A1 binds TLR4:LY96 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40125", "l": "an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61173", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200954", "l": "Nef Binds and activates the Src-family tyrosine kinase Lck (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44154", "l": "myo-inositol + phosphate => 1D-myo-inositol 2-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74517", "l": "aspoquinolone B => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018682", "l": "atrazine N-dealkylase activity", "d": ["Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18033", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.92", "l": "\"benzoate 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67041", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) => asnovolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68750", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32626", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62201", "l": "ethanol + 2 Fe(III)-[cytochrome c] => acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25707", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73429", "l": "H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether => genkwanin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42502", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74284", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14423", "l": "4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine => H2O + N(2)-benzoyl-D-arginine-4-nitroanilide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25662", "l": "(2E)-geranyl diphosphate = alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47398", "l": "an aliphatic alcohol + H(+) + octadecanoate => H2O + octadecanoate ester", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54852", "l": "H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59527", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] <=> 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965450", "l": "DAAM1 recruits PFN1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20915", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + taxa-4,11-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807872", "l": "Active ARF recruits coatomer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22874", "l": "CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070612", "l": "histone H2AR3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36595", "l": "hydrogen sulfide + NADP(+) = NADPH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008157", "l": "protein phosphatase 1 binding", "d": ["Binding to a protein phosphatase 1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23654", "l": "N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+) => N-terminal L-glutaminyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60785", "l": "2-oxoglutarate + gibberellin A24 + O2 => CO2 + gibberellin A25 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22388", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine = CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}, {"i": "EC:2.3.1.102", "l": "\"N(6)-hydroxylysine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61405", "l": "ATP + N-(D-ribulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59616", "l": "beta-alanyl-L-arginine + H2O = beta-alanine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21494", "l": "catechol + CO2 => 2,3-dihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851866", "l": "MET binds RANBP10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761474", "l": "AMOT-2 binds CDH11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61753", "l": "steviolbioside + UDP-alpha-D-glucose => H(+) + rebaudioside B + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21686", "l": "beta-alanine + H(+) + NADH + pyruvate => (R)-beta-alanopine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016428", "l": "tRNA (cytidine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64504", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine = 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55402", "l": "archaeosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875568", "l": "RAPGEF1 activates RAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37481", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43725", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51267", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70254", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102898", "l": "levopimaradienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 = levopiramadiene-diol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052929", "l": "ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity", "d": ["Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174963", "l": "NAT1 acetylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22895", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methenyltetrahydrofolate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50922", "l": "chromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66780", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O = N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75021", "l": "9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol => 1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29352", "l": "Zn(2+)(in) => Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32384", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72735", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67565", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate => adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17005", "l": "ATP + D-glucuronate = 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.43", "l": "\"glucuronokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74069", "l": "ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61871", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093332", "l": "p-EPHB phosphorylates SDC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047862", "l": "diisopropyl-fluorophosphatase activity", "d": ["Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + 2 H+ + hydrogen fluoride."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032050", "l": "clathrin heavy chain binding", "d": ["Binding to a clathrin heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507871", "l": "Aquaporins passively transport glycerol out of cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54247", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30886", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) <=> D-glucarate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700648", "l": "Active ALK binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.51", "l": "\"ophiolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23241", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56336", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.76", "l": "\"ent-isokaurene C2/C3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63781", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62179", "l": "GDP-alpha-D-glucose + H2O <=> alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683751", "l": "M protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31846", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19240", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide <=> 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.98.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664879", "l": "ATM:PEX5 binds ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.39", "l": "\"[butirosin acyl-carrier protein]--L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013143", "l": "RAC1 GEFs activate RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75783", "l": "ADP(in) = ADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990300", "l": "cellulosome binding", "d": ["Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1454916", "l": "The ABCC family mediates organic anion transport (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68482", "l": "CO2 + H2O + pentadecanal => (2R)-2-hydroperoxyhexadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928640", "l": "PAKs phosphorylate MLC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33778", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46337", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52210", "l": "H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69504", "l": "N-acetyl-D-glucosamine + O2 = H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67138", "l": "3-hydroxypropanoyl-CoA + ADP + phosphate => 3-hydroxypropanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052906", "l": "tRNA (guanine(37)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42080", "l": "all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52039", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate <=> L-isoleucine + tuberonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63803", "l": "GDP-alpha-D-mannose <=> GDP-beta-L-gulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953398", "l": "PIR oxygenates quercetin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875661", "l": "GGA3 associates with activated MET receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691167", "l": "CUL1, SKP1, FBXL5 bind (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25337", "l": "H2O + L-cysteinyl-tRNA(Cys) <=> H(+) + L-cysteine + tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29327", "l": "(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40537", "l": "2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27843", "l": "9H-carbazole + H(+) + NADPH + O2 => 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045031", "l": "G protein-coupled ATP receptor activity", "d": ["Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77325", "l": "5-(3-methylguanidino)-2-oxopentanoate + glycine => glyoxylate + N(omega)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34704", "l": "(2E,6E)-farnesyl diphosphate => (E)-2-epi-beta-caryophyllene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416510", "l": "GRK5 sequesters activated Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30854", "l": "beta-D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26536", "l": "3-hydroxypropanoyl-CoA + AMP + diphosphate => 3-hydroxypropanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35139", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + demethoxycurcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070677", "l": "rRNA (cytosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052691", "l": "UDP-arabinopyranose mutase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044377", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879273", "l": "mycothiol conjugates with electrophilic xenobiotic (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.1", "l": "\"non-specific serine/threonine protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373145", "l": "fumarate + H2O <=> malate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77042", "l": "4-hydroxyhexan-3-amine + H2O + NAD(+) <=> 4-hydroxyhexan-3-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42737", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50203", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592297", "l": "Full activation of MMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54472", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37557", "l": "kanosamine + phosphate => D-kanosamine 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940554", "l": "MMP2 cleaves OPTC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429415", "l": "SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202510", "l": "Activation of TAK1-TAB2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1364043", "l": "Tyrosine phosphorylation of PRLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035979", "l": "histone H2AXS139 kinase activity", "d": ["Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30134", "l": "H2O + octanoyl-[ACP] <=> H(+) + holo-[ACP] + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097020", "l": "COPII receptor activity", "d": ["Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71379", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805122", "l": "AURKB binds TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67764", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827867", "l": "Expression of TFAP2C in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761836", "l": "p14ARF binds NFE2L2:CREBBP, EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67433", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110360", "l": "Recruitment of POLB to the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296233", "l": "T2Rs bind bitter-tasting compounds (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72644", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21282", "l": "H(+) + 2 H2O2 + thiamine acetate => H2O + 2 O2 + thiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75244", "l": "FASL binds FAS Receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12221", "l": "H2O + L-leucine + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29371", "l": "dAMP + H2O = 2'-deoxyadenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001793", "l": "IgM receptor activity", "d": ["Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17625", "l": "D-lysopine + H2O + NADP(+) = H(+) + L-lysine + NADPH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.16", "l": "\"D-lysopine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49896", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate = 5,10-dihydrophenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34272", "l": "2-nitroimidazole + H2O => 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110244", "l": "Excision of FapyG by OGG1 glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22686", "l": "(2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67190", "l": "ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72947", "l": "acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21766", "l": "biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] => heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416929", "l": "PTGFR binds PGF2a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46279", "l": "(S)-malate + H(+) <=> (S)-lactate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67457", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60903", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005460", "l": "UDP-glucose transmembrane transporter activity", "d": ["Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28826", "l": "H(+)(in) + L-galactonate(in) <=> H(+)(out) + L-galactonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634834", "l": "ACHEIs bind ACHE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796617", "l": "MIB2 binds CFLAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392513", "l": "Rap1 signal termination by Rap1GAPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34124", "l": "3,5,7-trioxododecanoyl-CoA => CoA + H(+) + olivetolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72774", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67509", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27735", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418200", "l": "SRC-1 bound to ARRB2 is not activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12346", "l": "H(+) + L-glutamyl-tRNA(Glu) + NADPH => (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28382", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine = D-glucose 6-phosphate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5672951", "l": "Inactive RAFs bind YWHAB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693609", "l": "ATM phosphorylates TP53 at S15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036285", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604731", "l": "Autocatalytic activation of MMP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44937", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58335", "l": "(E)-non-2-en-1-ol + NADP(+) <=> (E)-non-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949413", "l": "HTMLYS translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647978", "l": "pro-RAS proteins are farnesylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37552", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate => 2-oxoglutarate + D-kanosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37899", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.42", "l": "\"tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047437", "l": "4-oxalocrotonate decarboxylase activity", "d": ["Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004099", "l": "chitin deacetylase activity", "d": ["Catalysis of the reaction: chitin + H2O = chitosan + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54446", "l": "a (2R,3R)-dihydroflavonol + H(+) + NADPH => a (2R,3S,4S)-leucoanthocyanidin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13139", "l": "cyclolaudenol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940134", "l": "FOLR2 binds FOLA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102106", "l": "curcumin synthase activity", "d": ["Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O = curcumin + 2 coenzyme A(4-) + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36594", "l": "(S)-2-chloropropanoate + NADP(+) <=> 2-chloroacrylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203553", "l": "eNOS binds NOSIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377640", "l": "Autophosphorylation of SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76203", "l": "n H(+)(out) + pyridoxine(out) = n H(+)(in) + pyridoxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698000", "l": "FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51027", "l": "H(+) + NADH + O2 + toluene-4-sulfonate <=> 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004662", "l": "CAAX-protein geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849900", "l": "SALMs1-3 bind each other in cis interactions (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63804", "l": "GDP-beta-L-gulose = GDP-beta-L-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56987", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030549", "l": "acetylcholine receptor activator activity", "d": ["Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638006", "l": "ARL3 hydrolyzes GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39530", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65872", "l": "1,17beta-dihydroxyandrostan-3-one + A = 17beta-hydroxyandrostan-1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40646", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69543", "l": "GTP + streptomycin <=> 6-O-guanylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22090", "l": "AMP + guanosine 3'-diphosphate 5'-triphosphate => ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23149", "l": "ATP + propanoate => ADP + propanoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50347", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH <=> 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029454", "l": "Autophosphorylation of PAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679044", "l": "FKBP1A binds sirolimus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614933", "l": "ACEIs bind ACE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717841", "l": "holo-FDPS dimer binds NBPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43326", "l": "1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102440", "l": "3',4',5'-trimethylmyricetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41942", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25100", "l": "ADP + UTP => ATP + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32652", "l": "erythromycin D + S-adenosyl-L-methionine => erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442739", "l": "PDPK1 phosphorylates RSKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034821", "l": "citronellol dehydrogenase activity", "d": ["Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39247", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA = (2E,11Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015487", "l": "melibiose:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27901", "l": "3'-AMP + H2O <=> adenosine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75143", "l": "prosolanapyrone III = solanapyrone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55096", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O = (3S)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30543", "l": "(S)-carnitine + ATP + CoA = (S)-carnitinyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001069", "l": "glycogen binding", "d": ["Binding to glycogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65857", "l": "A + a 1-hydroxy-3-oxo steroid => a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31598", "l": "(Z)-2-methylureidoacrylate + H2O <=> (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390302", "l": "tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047774", "l": "cis-2-enoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39537", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30471", "l": "(2Z,6Z)-farnesyl diphosphate = (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.54", "l": "\"(-)-endo-alpha-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17511", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) => H2O + thiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48126", "l": "a ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate => a ganglioside GD3 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29903", "l": "ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.5.2.7", "l": "\"ABC-type D-ribose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635845", "l": "GLI proteins bind CDC73 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047970", "l": "guanidinoacetase activity", "d": ["Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59646", "l": "D-xylobionate + H(+) => D-xylobiono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002145", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity", "d": ["Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48711", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665748", "l": "FMNL2 binds RHOC:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.10", "l": "\"ABC-type D-xylose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676595", "l": "TRAFs bind RANK:RANKL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50756", "l": "NADP(+) + reduced [flavodoxin] = 2 H(+) + NADPH + oxidized [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.19.1.1", "l": "\"flavodoxin--NADP(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.111", "l": "\"1,3-alpha-L-fucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51947", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine <=> 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0043733", "l": "DNA-3-methylbase glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228992", "l": "ROCK1,ROCK2 are activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691621", "l": "C5 binds C5 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.356", "l": "\"GDP-L-colitose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57481", "l": "2-hydroxydodecanoate + H2O2 => 2,3-dihydroxydodecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13837", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.64", "l": "\"phthalate 4,5-cis-dihydrodiol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61682", "l": "AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698005", "l": "FLT3 ITD mutants phosphorylate STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67157", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448702", "l": "Caspase-1 active tetramer formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27604", "l": "di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate => (2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39431", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.164", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863718", "l": "AGFG1 binds VAMP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63735", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan O-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453200", "l": "SYK autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44295", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54562", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60805", "l": "2-oxoglutarate + gibberellin A19 + O2 => CO2 + gibberellin A17 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34245", "l": "diphosphate + Mo-molybdopterin guanine dinucleotide => GTP + H(+) + Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57322", "l": "CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein] => acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036037", "l": "Defective IDUA does not hydrolyse Heparan sulfate chain(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23538", "l": "alpha-D-glucose 6-phosphate => alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28400", "l": "L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63524", "l": "2-propylphenol + H(+) + NADH + O2 = 3-propylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015328", "l": "cystine secondary active transmembrane transporter activity", "d": ["Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37784", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374664", "l": "Phosphorylation and activation of Ezrin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972979", "l": "POU5F1 (OCT4), NANOG bind the CDX2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74595", "l": "(2S,3R)-3-methyl-L-aspartate = mesaconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22514", "l": "hydrogenobyrinate => 3 H(+) + precorrin-8X", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55545", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140360", "l": "cyclic-GMP-AMP transmembrane transporter activity", "d": ["Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34586", "l": "2-oxoglutarate + O2 + pentalenolactone D <=> CO2 + H2O + pentalenolactone E + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007882", "l": "IL1F10 is cleaved (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660557", "l": "RAS:GTP binds RAL GDS proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69044", "l": "2-nitrobutanedioate = fumarate + H(+) + nitrite", "d": [], "t": []}, {"i": "EC:4.3.99.5", "l": "\"nitrosuccinate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449058", "l": "Interleukin-1 family are secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14840", "l": "glyoxylate + H2O + O2 <=> H(+) + H2O2 + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38811", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.991992031210344", "identifiers": [{"i": "GO:0016875", "l": "ligase activity, forming carbon-oxygen bonds", "d": ["Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.1.-.-", "l": "\"Forming carbon-oxygen bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29046", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68165", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211164", "l": "AKT phosphorylates FOXO1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39670", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983707", "l": "SYK autophosphorylates at the activated BCR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0045296", "l": "cadherin binding", "d": ["Binding to cadherin, a type I membrane protein involved in cell adhesion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42662", "l": "H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => NAD(+) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161612", "l": "PGH2 is reduced to PGF2a by FAM213B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14573", "l": "D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.40", "l": "\"glucarate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033190", "l": "solanapyrone synthase activity", "d": ["Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67231", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA <=> (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.21", "l": "\"dipeptidase E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797090", "l": "CCNK binds CDK12 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783483", "l": "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37911", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209193", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047760", "l": "butyrate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12464", "l": "myo-inositol + UDP-alpha-D-galactose = alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.123", "l": "\"inositol 3-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20309", "l": "2 H2O2 = 2 H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362427", "l": "Hh-Np binds GPC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727819", "l": "TAK1 phosphorylates MKK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098973", "l": "structural constituent of postsynaptic actin cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72129", "l": "agmatine(out) + H(+)(in) => agmatine(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32817", "l": "Hg(2+)(out) => Hg(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981892", "l": "Active G alpha (z) binds RGS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.12", "l": "\"alpha-lytic endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65634", "l": "an N-tetracosanoyl-sphingoid base + CoA + H(+) => a sphingoid base + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34271", "l": "2-nitroimidazole + H2O = 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": [], "t": []}, {"i": "EC:3.5.99.9", "l": "\"2-nitroimidazole nitrohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61235", "l": "H2O + L-isoleucine + O2 <=> (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709406", "l": "CO binds to Cytochrome c oxidase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047025", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity", "d": ["Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391211", "l": "Trace amine-associated receptors can bind trace amines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21809", "l": "2,5-dioxopiperazine + H2O => glycylglycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34546", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33902", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose <=> FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53682", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5606996", "l": "Soluble PROCR binds activated protein C (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66958", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696271", "l": "RND1 binds effectors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44369", "l": "Cr(6+) + 2 NADPH + O2 => Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12955", "l": "ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein] => ATP + L-seryl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19475", "l": "3,4-dihydroxybenzoate + H2O + NAD(+) => 4-hydroxybenzoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67999", "l": "(Z)-1,2-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56453", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-hapalindole U", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631885", "l": "PRDX1 overoxidizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44187", "l": "D-sedoheptulose 7-phosphate <=> 2-epi-5-epi-valiolone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36935", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029272", "l": "Release of PLCG from FCGR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60060", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168875", "l": "Trimerization of HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73926", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine <=> griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36789", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865454", "l": "CBFB binds RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950183", "l": "IL12B binds IL23A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429529", "l": "Thrombin binding to GP1b:IX:V (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19344", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] <=> H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33636", "l": "ATP + CoA + docosanoate => AMP + diphosphate + docosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.109", "l": "\"dolichyl-phosphate-mannose--protein mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39201", "l": "(2E)-tetracosenoyl-CoA + H2O => (3R)-hydroxytetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199456", "l": "PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047677", "l": "arachidonate 8(R)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10874", "l": "a carboxylate + L-aspartate => H2O + N-acyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11310", "l": "ADP + H(+) + malonyl-CoA + phosphate => acetyl-CoA + ATP + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26403", "l": "(2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone => all-trans-10'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54296", "l": "GTP + L-tyrosyl-[protein] = diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.7.n6", "l": "\"guanine phosphate-protein transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63985", "l": "5-hydroxyuridine + ATP => 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41633", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32418", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60728", "l": "citral + H2O + NADP(+) = 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950365", "l": "Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68573", "l": "L-tyrosine(in) => L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16779", "l": "ADP + H(+) + K(+)(in) + phosphate => ATP + H2O + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706393", "l": "RHOBTB3 binds ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67252", "l": "H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51407", "l": "H2O + L-arginine + O2 <=> 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56377", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0019238", "l": "cyclohydrolase activity", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419428", "l": "S1PR2-5 bind S1P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33538", "l": "H2O + lanosteryl ester <=> a carboxylate + H(+) + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015576", "l": "sorbitol transmembrane transporter activity", "d": ["Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16617", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate = alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.31", "l": "\"laminaribiose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23960", "l": "H(+) + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal", "d": [], "t": []}, {"i": "EC:1.11.1.3", "l": "\"fatty-acid peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13627", "l": "3-methyl-2-butenal + adenine + AH2 => A + H2O + N(6)-dimethylallyladenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010313", "l": "phytochrome binding", "d": ["Binding to a phytochrome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36008", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202500", "l": "Activation of IKK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250488", "l": "GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.449113659480474", "identifiers": [{"i": "GO:0030533", "l": "triplet codon-amino acid adaptor activity", "d": ["The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41910", "l": "(2E)-hexadecenoyl-[ACP] + H2O => (3R)-hydroxyhexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66798", "l": "11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-350769", "l": "trans-Golgi Network Coat Activation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65810", "l": "dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46839", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799246", "l": "CHEK1 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682826", "l": "LGI1 binds ADAM11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933525", "l": "Phosphorylation and release of IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18208", "l": "AH2 + O2 + progesterone <=> 11alpha-hydroxyprogesterone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.4", "l": "\"Xaa-Arg dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44982", "l": "CoA + O-butanoyl-(R)-carnitine => (R)-carnitine + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53079", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60840", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68613", "l": "H(+) + NADPH + prostaglandin E1 => NADP(+) + prostaglandin F1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937814", "l": "RUNX3 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65308", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.294", "l": "\"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51712", "l": "keto-D-tagatose 6-phosphate = keto-D-fructose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.40", "l": "\"D-tagatose 6-phosphate 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61579", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) <=> (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005344", "l": "oxygen carrier activity", "d": ["Binding to oxygen and delivering it to an acceptor molecule or a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77044", "l": "5-hydroxyoctan-4-amine + H2O + NAD(+) => 5-hydroxyoctan-4-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33476", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71006", "l": "L-histidine(in) + L-phenylalanine(out) <=> L-histidine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31520", "l": "O2 + torulene => 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77366", "l": "2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77383", "l": "H(+) + hnu + octanoate = CO2 + heptane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102620", "l": "3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity", "d": ["Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54267", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768993", "l": "NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52262", "l": "a bacteriochlorophyllide e + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide c", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033946", "l": "xyloglucan-specific endo-beta-1,4-glucanase activity", "d": ["Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28924", "l": "H(+)(in) + L-phenylalanine(in) => H(+)(out) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130731", "l": "Formation of COPII vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37278", "l": "H2O + L-alanyl-L-glutamine <=> L-alanine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43614", "l": "5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(341) in tmRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74952", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 => (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18592", "l": "[glutamine synthetase]-L-tyrosine + ATP <=> [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9633044", "l": "ESR binds STRN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21660", "l": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.7", "l": "\"benzaldehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48464", "l": "a ganglioside GM1b + H2O = a ganglioside GA1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785762", "l": "IL13RA1 binds TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033755", "l": "sulfur oxygenase/reductase activity", "d": ["Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252001", "l": "ATP1B4 binds SNW1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67971", "l": "H2O + presqualene diphosphate <=> H(+) + phosphate + presqualene monophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46842", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350769", "l": "trans-Golgi Network Coat Activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73414", "l": "succinate(in) + sulfate(out) <=> succinate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051109", "l": "crotonobetaine-CoA ligase activity", "d": ["Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22569", "l": "ascopyrone M => ascopyrone P", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63617", "l": "prunetin + UDP-alpha-D-glucuronate => H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16892", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate <=> 6-acetamido-3-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73835", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.156", "l": "\"geranylfarnesylglycerol-phosphate geranylfarnesyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821486", "l": "HCFC1 binds SET1A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45932", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60611", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61170", "l": "H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209738", "l": "VD3 binds GC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72184", "l": "creatinine(in) + H(+)(out) => creatinine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64703", "l": "1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28479", "l": "galactarate(in) + H(+)(in) => galactarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44820", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45843", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) <=> 3-oxodecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937792", "l": "RUNX3 binds SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67727", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) <=> CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19040", "l": "an epoxide + H2O <=> an ethanediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004931", "l": "extracellularly ATP-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}, {"i": "REACT:R-HSA-877187", "l": "P2X7 mediates loss of intracellular K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734687", "l": "ORC6 is phosphorylated on T195 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48518", "l": "dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14547", "l": "NH4(+) + nicotinate => H2O + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018517", "l": "phthalate 4,5-cis-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106343", "l": "glutarate dioxygenase activity", "d": ["Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038198", "l": "auxin receptor activity", "d": ["Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755303", "l": "26S proteasome degrades HIFalpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983299", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668545", "l": "NIK autophosphorylates on T559 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0043121", "l": "neurotrophin binding", "d": ["Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29935", "l": "cytosine(in) + H(+)(in) = cytosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50386", "l": "5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70245", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782820", "l": "USP17 deubiquitinates SUDS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26275", "l": "Co-precorrin-4 + S-adenosyl-L-homocysteine => Co-precorrin-3 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30290", "l": "15-cis-phytoene + 2 a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50207", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.121", "l": "\"polymannuronate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0015929", "l": "hexosaminidase activity", "d": ["Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848339", "l": "PNPLA5 hydrolyzes TAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66951", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42879", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27542", "l": "methanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.83", "l": "\"4-hydroxyphenylacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168310", "l": "Release of the RNP into the host cell nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529020", "l": "CK2 phosphorylates condensin I subunits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696960", "l": "USP49 deubiquitinates H2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696813", "l": "TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30264", "l": "H2O2 + 2 L-ascorbate => 2 H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.44", "l": "\"phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41125", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54422", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) => 3',3'-c-di-AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16646", "l": "H2O + hexadecanoyl-CoA => CoA + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.37", "l": "\"malate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202168", "l": "Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70120", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046970", "l": "NAD-dependent histone H4K16 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694441", "l": "CSNK1D phosphorylates SEC23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418553", "l": "cAMP degradation by Phosphodiesterases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169394", "l": "ISGylation of IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.50", "l": "\"lysyl endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72893", "l": "acetylcholine(in) + 2 H(+)(out) => acetylcholine(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614614", "l": "Cysteine is degraded to serine and H2S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793975", "l": "Expression of GATA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044012", "l": "histone H2AK9 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517731", "l": "Expression of IL-8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64603", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24993", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70527", "l": "H(+) + N-acyl-3-oxosphinganine + NADH = an N-acylsphinganine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39906", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44922", "l": "(3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562564", "l": "Caspase-8 processing within TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18701", "l": "arsenite + H2O + 2 oxidized [azurin] = arsenate + 3 H(+) + 2 reduced [azurin]", "d": [], "t": []}, {"i": "EC:1.20.9.1", "l": "\"arsenate reductase (azurin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634442", "l": "KLF5 gene expression is enhanced by CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10362", "l": "3-(2-hydroxyphenyl)propanoate + H(+) => 3,4-dihydrocoumarin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74513", "l": "aspoquinolone A => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879910", "l": "JAK2 is phosphorylated, activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11910", "l": "butanoate + H(+) + pentan-2-one => H2O + nonane-4,6-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46464", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034348", "l": "type III interferon receptor activity", "d": ["Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52426", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604732", "l": "Autocatalytic activation of proMMP13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193964", "l": "CYP21A2 21-hydroxylates PROG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49296", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.206", "l": "\"protein-N(pi)-phosphohistidine--L-sorbose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868071", "l": "Clathrin recruits PIK3C2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033526", "l": "USP9X binds Ub:PEX5S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39980", "l": "(+-)-pavine + S-adenosyl-L-methionine => H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5220959", "l": "TDG excises 5-formylcytosine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64735", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033851", "l": "lavandulyl diphosphate synthase activity", "d": ["Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69042", "l": "2-nitrobutanedioate + H2O + NADP(+) => (2S)-2-nitrosobutanedioate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68683", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) <=> 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34510", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate <=> N,N-diacetyllegionaminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358789", "l": "Self-ubiquitination of RNF41 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12136", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807826", "l": "LDHAL6B reduces PYR to LACT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663124", "l": "p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102881", "l": "(+)-beta-barbatene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-beta-barbatene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20408", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755304", "l": "MUL1 ubiquitinates UBXN7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.24", "l": "\"rhamnogalacturonan exolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42323", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031404", "l": "chloride ion binding", "d": ["Binding to a chloride ion (Cl-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23879", "l": "protoaphin aglucone <=> H2O + xanthoaphin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74478", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 <=> (-)-4'-methoxycyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10170", "l": "biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017060", "l": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12591", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209925", "l": "DIT and MIT combine to form triiodothyronine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659611", "l": "ANO1 inhibitors bind ANO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53612", "l": "CTP + D-ribulose 5-phosphate + H(+) = CDP-D-ribulose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22925", "l": "dCMP + H(+) + H2O => dUMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.6", "l": "\"lysine/arginine leucyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030275", "l": "LRR domain binding", "d": ["Binding to a LRR domain (leucine rich repeats) of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76133", "l": "3',5'-cyclic GMP(in) + a dicarboxylate(out) => 3',5'-cyclic GMP(out) + a dicarboxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64852", "l": "benzoyl-CoA + octan-1-ol = CoA + octyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109700", "l": "AKT2 binds PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61370", "l": "4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone sulfate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061784", "l": "peptidoglycan N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177923", "l": "Sustained activation of SRC kinase by SHP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55367", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140842", "l": "RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72103", "l": "Formation of pre-mRNPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707516", "l": "FeHM dissociates from MetHb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13011", "l": "formate + H(+) + L-kynurenine => H2O + N-formyl-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51234", "l": "2-glyceryl-prostaglandin D2 => 2-glyceryl-prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941895", "l": "Formation of CDK4/6:CCND complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64892", "l": "holo-[ACP] + tetradecanoyl-AMP = AMP + H(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928646", "l": "EPHAs bind EFNAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49492", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199518", "l": "C3d-complexed antigen binds to complement receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27782", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613666", "l": "p-PLINs translocate from lipid droplet surface to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61826", "l": "H(+) + pregnenolone 3-beta-D-glucoside + UDP => pregnenolone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28656", "l": "glutathione S,S-dioxide + H2O => glutathione + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051373", "l": "FATZ binding", "d": ["Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23141", "l": "beta-nicotinamide D-ribonucleotide + H2O => D-ribose 5-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54367", "l": "2 acetaldehyde <=> acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578712", "l": "Importin-8 binds AGO2:miRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10716", "l": "D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate", "d": [], "t": []}, {"i": "EC:5.5.1.4", "l": "\"inositol-3-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184269", "l": "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59473", "l": "2',3'-cGAMP + H2O => Gp(2'-5')Ap(3') + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11511", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050298", "l": "stizolobinate synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41975", "l": "a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55202", "l": "2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine => 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58178", "l": "all-trans-lycopaoctaene + 2 diphosphate + NADP(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28879", "l": "H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60048", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16671", "l": "H(+) + NADH + urate => H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10962", "l": "(R)-lactate => (S)-lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60418", "l": "H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 => diglucosyl-enterobactin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70971", "l": "citrate <=> isocitrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68453", "l": "all-trans-10'-apo-beta-carotenal + O2 => 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14551", "l": "2-oxopent-4-enoate + formate + H(+) => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50530", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50066", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + H2O + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49528", "l": "(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.101", "l": "\"poly(ethylene terephthalate) hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418856", "l": "Activation of Rac1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41601", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34929", "l": "glutathione + glutathioselenol + NADP(+) => H(+) + NADPH + selenodiglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607058", "l": "Activated protein C:PROCR binds F2R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953111", "l": "E2F6 binds TFDP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938507", "l": "miR-106a binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38062", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA <=> 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610720", "l": "PKA phosphorylates GLI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047231", "l": "pyridoxine 5'-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59211", "l": "ATP + H(+) + octadecanoate <=> diphosphate + octadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986446", "l": "IL26 binds IL20RA:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49981", "l": "H2O + hexanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31284", "l": "FAD + H(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042020", "l": "interleukin-23 receptor activity", "d": ["Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604763", "l": "Autocatalytic activation of MMP7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389350", "l": "Activation of Cdc42 by pVav1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15535", "l": "3-sulfopyruvate + H(+) + NADH => (2R)-3-sulfolactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047939", "l": "L-glucuronate reductase activity", "d": ["Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18453", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O = [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.5.2.3", "l": "\"ABC-type beta-glucan transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426150", "l": "SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782943", "l": "UV-DDB ubiquitinates XPC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191636", "l": "Phosphorylation of Cx43 by c-src (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37728", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12366", "l": "a quinol + beta-nicotinamide D-riboside => 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371422", "l": "ATP hydrolysis by HSP70 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20773", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) => 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64650", "l": "(E)-feruloyl-CoA + H(+) + NADPH => (E)-coniferaldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62208", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47313", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53516", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42286", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351456", "l": "Association of gamma H2AX and NBS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13727", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => acetyl-CoA + alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20139", "l": "baccatin III + CoA => 10-deacetylbaccatin III + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179417", "l": "Multiubiquitination of Nek2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42866", "l": "H(+) + norspermine + S-methyl-5'-thioadenosine => norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700156", "l": "Active ALK dimer binds IRS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15112", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061928", "l": "glutathione specific gamma-glutamylcyclotransferase activity", "d": ["Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40649", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69571", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218805", "l": "PKC autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18400", "l": "ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39583", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009208", "l": "Activated ERKs phosphorylate RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687107", "l": "MAPK4,6 translocate to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34897", "l": "ADP + H(+) + phosphate + selenite(in) => ATP + H2O + selenite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17338", "l": "catechol + O2 => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688459", "l": "RIPK3 binds HSP90:CDC37 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071111", "l": "cyclic-guanylate-specific phosphodiesterase activity", "d": ["Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693478", "l": "HTR1A binds HTR1A agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74497", "l": "yaequinolone C => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28549", "l": "alpha-D-glucose <=> alpha-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562564", "l": "Caspase-8 processing within TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53901", "l": "ATP + L-threonyl-[myosin light chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25845", "l": "(1S,5R)-carveol + NAD(+) => (R)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420131", "l": "The PACAP receptor binds PACAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619667", "l": "PRX gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12315", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011543", "l": "DCA binds PDK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651828", "l": "PARG dePARylates PARP1,PARP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34617", "l": "H(+) + hydrogencarbonate + methylphosphonate => 2-hydroxyethylphosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24928", "l": "H2O + L-cystine => NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.95", "l": "\"dextran 1,6-alpha-isomaltotriosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3878123", "l": "Initiation of SAHF formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649856", "l": "Oxidative damage to the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25334", "l": "H2O + L-cysteinyl-tRNA(Cys) = H(+) + L-cysteine + tRNA(Cys)", "d": [], "t": []}, {"i": "EC:3.6.1.n3", "l": "\"L-cysteinyl-tRNA(Cys) hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52095", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047234", "l": "raffinose-raffinose alpha-galactotransferase activity", "d": ["Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48708", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38179", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24796", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508513", "l": "PTK2B binds JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708557", "l": "FBXL17 binds BACH1:MAFK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981657", "l": "IL34 dimer binds PTPRZ1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62731", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28901", "l": "glycine(out) + H(+)(out) => glycine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15329", "l": "(S)-ureidoglycolate + NAD(+) = H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380294", "l": "Loss of C-Nap-1 from centrosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51734", "l": "H(+) + meleagrin + S-adenosyl-L-homocysteine => glandicoline B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858475", "l": "ppDVL recruits RAC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25917", "l": "A + H2O + quinolin-6-ol => 6-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877902", "l": "Activated AR binds RUNX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76168", "l": "glycyl-L-leucine(out) + 2 H(+)(out) => glycyl-L-leucine + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43661", "l": "ATP + hydrogencarbonate + propanoyl-CoA => ADP + H(+) + methylmalonyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52572", "l": "butanoyl-CoA + NAD(+) = (2E)-butenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19158", "l": "D-xylonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53129", "l": "delta-carotene => epsilon-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14057", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid = a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11184", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O = beta-alanine + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9660557", "l": "RAS:GTP binds RAL GDS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047136", "l": "4-(dimethylamino)phenylazoxybenzene reductase activity", "d": ["Catalysis of the reaction: 4-(dimethylamino)azobenzene + H2O + NADP+ = 4-(dimethylamino)phenylazoxybenzene + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862733", "l": "CCR2, CCR3 bind CCL13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656438", "l": "Defective ALDOB does not cleave Fru 1-P to GA and DHAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65541", "l": "a ganglioside GM3 + H2O => an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36683", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:2.3.1.225", "l": "\"protein S-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27432", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4837364", "l": "Secretion of SOD3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39642", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA <=> (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71774", "l": "2 Cu(+) + H(+) + NADP(+) <=> 2 Cu(2+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75852", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57758", "l": "C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015553", "l": "xanthosine transmembrane transporter activity", "d": ["Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690461", "l": "FKBP1A binds tacrolimus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47268", "l": "bacterioruberin = H2O + monoanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25903", "l": "D-arabino-hex-3-ulose 6-phosphate <=> beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803063", "l": "RNASEs bind bacterial LPS, PGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18367", "l": "CO2 + NADH + pyruvate => (R)-malate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31484", "l": "soyasapogenol E + UDP-alpha-D-glucuronate => H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451418", "l": "Pellino ubiquitinates IRAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333671", "l": "CLCAs self cleave (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665748", "l": "FMNL2 binds RHOC:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28552", "l": "CoA + N-acetylanthranilate => acetyl-CoA + anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709317", "l": "CO binds to free ferrohemoglobin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67574", "l": "adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + alpha-muricholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27988", "l": "H(+) + methylglyoxal + NADPH => hydroxyacetone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53672", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369052", "l": "ABCAs mediate lipid influx (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626816", "l": "PIN1 binds p-S345-NCF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18873", "l": "3-chloro-D-alanine + H2O = chloride + H(+) + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.5.1.2", "l": "\"3-chloro-D-alanine dehydrochlorinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20960", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16604", "l": "L-aspartate <=> fumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166214", "l": "FA anion flip-flops to the opposite surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42244", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA = 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12268", "l": "2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36653", "l": "H(+) + novobiocic acid + S-adenosyl-L-homocysteine => 8-desmethylnovobiocic acid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68059", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622390", "l": "Activation of TRPC channels by Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950591", "l": "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77072", "l": "(2E,6E)-farnesyl diphosphate => (1R,4R,5S)-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50482", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39067", "l": "3-oxooctanedioyl-CoA + CoA = acetyl-CoA + hexanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551648", "l": "SUMOylation of TDG with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61167", "l": "kaempferol + UDP-beta-L-rhamnose <=> H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53020", "l": "a plastoquinone + an L-alpha-amino acid + H2O = a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166038", "l": "GPI-bound CD14 binds LPS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47813", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71133", "l": "H(+)(out) + L-asparagine(in) + Na(+)(in) => H(+)(in) + L-asparagine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43327", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847534", "l": "RAB43 hydrolyses GTP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52675", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55997", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12362", "l": "13-(2-methylcrotonoyloxy)lupanine + CoA => (2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54356", "l": "3-methyl-2-oxobutanoate + H(+) = 2-methylpropanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51365", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine => CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35271", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38893", "l": "hexadecanoate + sphing-4-enine => H2O + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0008417", "l": "fucosyltransferase activity", "d": ["Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}, {"i": "REACT:R-HSA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63439", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390597", "l": "Release Of ADP From Myosin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71979", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59431", "l": "3-hydroxypropanal + H2O + NADP(+) <=> 3-hydroxypropanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.42", "l": "\"flavone 3'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36902", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61155", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44257", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58610", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-decanoylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008812", "l": "choline dehydrogenase activity", "d": ["Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212222", "l": "PRC2 recruits DNA methyltransferases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35483", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680348", "l": "PIK3R1:PIK3CA,B,G (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613497", "l": "Unwinding DNA for the nascent transcript (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48115", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37161", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964284", "l": "BTK in active Gq-BTK complex is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805061", "l": "CK2 binds FACT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60456", "l": "ATP + UTP = 3',3'-cUAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395517", "l": "NADPH transfers electrons to FDXR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10747", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) <=> 3,4-dihydroxybenzoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44787", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine <=> H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41959", "l": "2',3'-cyclophospho-CMP + H2O <=> cytidine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70448", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74054", "l": "D-threonine(out) + L-alanine(in) <=> D-threonine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655142", "l": "RCHY1 binds POLH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69237", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 4-hydroxybutylnitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019176", "l": "dihydroneopterin monophosphate phosphatase activity", "d": ["Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009045", "l": "xylose isomerase activity", "d": ["Catalysis of the reaction: D-xylose = D-xylulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888589", "l": "Release of GABA at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0034595", "l": "phosphatidylinositol phosphate 5-phosphatase activity", "d": ["Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20587", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin => loganin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67636", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate = dZMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15246", "l": "a monoacylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24297", "l": "(S)-dihydroorotate + H2O => H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675790", "l": "MTORC1 dissociates from ULK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46808", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine = [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.318", "l": "\"[trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73278", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine <=> 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47352", "l": "a hexanoate ester + H2O = an aliphatic alcohol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756661", "l": "EOMES and TBXT bind the SOX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25832", "l": "1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine", "d": [], "t": []}, {"i": "EC:1.1.1.369", "l": "\"D-chiro-inositol 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70858", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) <=> L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.-", "l": "\"Hydroxymethyl-, formyl- and related transferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851092", "l": "NPM1-ALK and FOXM1-dependent CCNB1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865482", "l": "KMT2A (MLL) binds RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38088", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050378", "l": "UDP-glucuronate 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75710", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate <=> 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75514", "l": "acetyl-CoA + S-benzyl-L-cysteine <=> CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50080", "l": "ATP + H2O + taurodeoxycholate(in) = ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16398", "l": "2 D-glucopyranose 1-phosphate => D-glucose + D-glucose 1,6-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48390", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29604", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28487", "l": "Fe(2+)(in) => Fe(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38104", "l": "L-galactonate => 2-dehydro-3-deoxy-L-galactonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54714", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160129", "l": "protein-DNA covalent cross-linking activity", "d": ["Catalysis of the cross-link between a protein and a DNA abasic site, forming a thiazolidine linkage between a DNA ring-opened abasic site and the alpha-amino and sulfhydryl substituents of cysteine residue of the protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53811", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209293", "l": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44415", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24002", "l": "a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein] => a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9707856", "l": "PGRMC2:Hemes dissociates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0032450", "l": "maltose alpha-glucosidase activity", "d": ["Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648268", "l": "HTR1A binds HTR1A antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29853", "l": "2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130706", "l": "MHC class II antigen processing (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53606", "l": "1-hexadecanoyl-sn-glycerol + phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864577", "l": "TFAP2C translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41775", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GQ1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71055", "l": "L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.653457143972261", "identifiers": [{"i": "GO:0016822", "l": "hydrolase activity, acting on acid carbon-carbon bonds", "d": ["Catalysis of the hydrolysis of any acid carbon-carbon bond."], "t": []}, {"i": "EC:3.7.-.-", "l": "\"Acting on carbon-carbon bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36494", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36108", "l": "gibberellin A4 + S-adenosyl-L-methionine => O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21573", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 => CO + H(+) + N-acetylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016414", "l": "O-octanoyltransferase activity", "d": ["Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42128", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19242", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928591", "l": "EPH:EFN tetramers oligomerise (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176956", "l": "Formation of GINS complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193981", "l": "CYP21A2 oxidises 17HPROG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67272", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70948", "l": "L-tryptophan(in) => L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60827", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate <=> 2 AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380294", "l": "Loss of C-Nap-1 from centrosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29119", "l": "a ubiquinol + nitrate = a ubiquinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75402", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) <=> 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52727", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate <=> a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033870", "l": "thiol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71598", "l": "2-oxoglutarate(out) + succinate(in) <=> 2-oxoglutarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40693", "l": "1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018561", "l": "2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55576", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine = H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467794", "l": "Resolution of sister chromatids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769000", "l": "NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16739", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => H(+) + NADH + O2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21210", "l": "L-serine + phosphate => H2O + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199112", "l": "CRTAM binds to NECL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74889", "l": "2',3'-cGAMP(out) + ADP + H(+) + phosphate => 2',3'-cGAMP(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854052", "l": "Formation of the SCF-FBXL7 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433501", "l": "Interaction of other adapter proteins with p-KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015111", "l": "iodide transmembrane transporter activity", "d": ["Enables the transfer of iodide ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49257", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018747", "l": "RHOQ GEFs activate RHOQ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65313", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33703", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033923", "l": "glucan 1,6-alpha-isomaltosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10541", "l": "7,8-dihydroneopterin => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443831", "l": "14-3-3-zeta binds Raf1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419841", "l": "Light stimulates opsin receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033843", "l": "xyloglucan 6-xylosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44070", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77426", "l": "cyclohexanecarbaldehyde + hydrogen cyanide <=> (2S)-2-cyclohexyl-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43624", "l": "2-aminomalonate semialdehyde + H(+) = aminoacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981621", "l": "C3 convertases spontaneously dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005260", "l": "intracellularly ATP-gated chloride channel activity", "d": ["Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60738", "l": "(2E,6E)-farnesoate + 2 H(+) + NADPH => (2E,6E)-farnesal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59707", "l": "D-cellohexaono-1,5-lactone + H2O <=> D-cellohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50172", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33965", "l": "ADP + isopentenyl diphosphate => ATP + isopentenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34186", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796691", "l": "SPATA2 links CYLD to LUBAC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19141", "l": "all-trans-retinol = 11-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321883", "l": "MSL acetylates histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805479", "l": "TP53RK phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71977", "l": "glutathione(in) + 3 Na(+)(in) => glutathione(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67808", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937369", "l": "ATAD2 binds ESR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051082", "l": "unfolded protein binding", "d": ["Binding to an unfolded protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823966", "l": "EOMES, SMAD2,3, MIXL1 bind the GSC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54057", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-hedycaryol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26533", "l": "4-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23461", "l": "benzyl cetraxate + H2O => benzyl alcohol + cetraxate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35893", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847968", "l": "PTEN binds FRK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31024", "l": "squalene => dammara-20,24-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49004", "l": "aurachin C + H(+) + NADPH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24095", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2S)-bisdechlorogeodin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716913", "l": "ESR1 binds ESR1 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61062", "l": "a neolactoside nLc4Cer + H(+) + UDP => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17452", "l": "(2E)-geranyl diphosphate + flaviolin <=> 3-linalylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33528", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol => CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432054", "l": "Aquaporin-1 passively transports water out of cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043135", "l": "5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50993", "l": "thromboxane B2(out) => thromboxane B2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42636", "l": "AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin", "d": [], "t": []}, {"i": "EC:2.8.1.9", "l": "\"molybdenum cofactor sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16916", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53085", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23592", "l": "glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693148", "l": "BCKDK phosphorylates BCKDH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33562", "l": "an acyl-CoA + sn-glycerol 3-phosphate <=> a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47464", "l": "(3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030560", "l": "tRNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45453", "l": "H2O + N-tetradecanoylethanolamine => ethanolamine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29534", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46413", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14134", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.653457143972261", "identifiers": [{"i": "GO:0008134", "l": "transcription factor binding", "d": ["Binding to a transcription factor, a protein required to initiate or regulate transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64686", "l": "3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626549", "l": "IQGAPs bind CALM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27960", "l": "cytosine + D-ribose => cytidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033825", "l": "oligosaccharide 4-alpha-D-glucosyltransferase activity", "d": ["Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24056", "l": "a myo-inositol phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199014", "l": "CD96 binds PVR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66375", "l": "H2O + sn-glycerol 3-phosphate <=> glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168849", "l": "tBID binds to inactive BAX protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31977", "l": "7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxusin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45918", "l": "4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53097", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13576", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate <=> [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653974", "l": "Ragulator binds Rag dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27738", "l": "2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950057", "l": "IL12RB1 binds TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13218", "l": "H2O + NAD(+) + succinate semialdehyde => 2 H(+) + NADH + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697057", "l": "esxG binds esxH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29490", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-3,5-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23002", "l": "(R)-4-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24436", "l": "H2 + methanophenazine = dihydromethanophenazine", "d": [], "t": []}, {"i": "EC:1.12.98.3", "l": "\"Methanosarcina-phenazine hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14825", "l": "(1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.275", "l": "\"(+)-trans-carveol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29345", "l": "L-aspartate(out) + succinate(in) => L-aspartate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62968", "l": "(R)-lactate + NADP(+) = H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664871", "l": "NBR1 translocates from cytosol to perixosomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14935", "l": "N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165033", "l": "Multimerization of Rev (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56964", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141341", "l": "SMOX-3 oxidises SPN to SPM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33158", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42230", "l": "AH2 + estrone => 17beta-estradiol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12451", "l": "(R)-pantothenate + H2O <=> (R)-pantoate + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31735", "l": "3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097079", "l": "selenite:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39049", "l": "2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050513", "l": "glycoprotein 2-beta-D-xylosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23507", "l": "adenosylcob(III)inamide + H2O <=> (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14022", "l": "AH2 + ecdysone + O2 => 20-hydroxyecdysone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417896", "l": "P2Y6 receptor can bind to UDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047609", "l": "acetylputrescine deacetylase activity", "d": ["Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34361", "l": "a 2-acylglycerol + a carboxylate + H(+) => a 1,2-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247837", "l": "WNT ligands traffic to the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61169", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004968", "l": "gonadotropin-releasing hormone receptor activity", "d": ["Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31156", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58668", "l": "3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37726", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71758", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) <=> 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646468", "l": "mTORC1 binds RHEB:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18012", "l": "glutaryl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18509", "l": "H(+) + H2O2 + NADH = 2 H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.11.1.1", "l": "\"NADH peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10943", "l": "(2E)-geranyl diphosphate <=> (4R)-limonene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57462", "l": "4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP => (E)-sinapyl alcohol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928578", "l": "EPH receptors autophosphorylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75067", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.201143870267188", "identifiers": [{"i": "GO:0016776", "l": "phosphotransferase activity, phosphate group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)."], "t": []}, {"i": "EC:2.7.4.-", "l": "\"Phosphotransferases with a phosphate group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61688", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine = AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.70", "l": "\"L-threonine--[L-threonyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41395", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34342", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23588", "l": "oxalate + succinyl-CoA = oxalyl-CoA + succinate", "d": [], "t": []}, {"i": "EC:2.8.3.2", "l": "\"oxalate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46223", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57159", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199839", "l": "AKT can phosphorylate RSK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067640", "l": "IL6 binds IL6R-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749609", "l": "BCHE hydrolyzes ASA- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047161", "l": "tartronate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36156", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine => A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203979", "l": "Coat Assembly (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035888", "l": "isoguanine deaminase activity", "d": ["Catalysis of the reaction: isoguanine + H2O = xanthine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75593", "l": "(11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61323", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34534", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18301", "l": "ATP + NH4(+) + XMP = AMP + diphosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64719", "l": "NADP(+) + propanal <=> acrolein + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11940", "l": "2 H(+) + H2O + L-citrulline = CO2 + L-ornithine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.20", "l": "\"citrullinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14620", "l": "CoA + glutathione + NADP(+) <=> CoA-glutathione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28037", "l": "[thioredoxin]-disulfide + dADP + H2O <=> [thioredoxin]-dithiol + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74601", "l": "AMP(in) + UDP-alpha-D-galactose(out) => AMP(out) + UDP-alpha-D-galactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53138", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18571", "l": "an aromatic carboxylate + H(+) + H2O2 => an aromatic aldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51634", "l": "all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27625", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate <=> 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18257", "l": "coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": [], "t": []}, {"i": "EC:1.3.3.3", "l": "\"coproporphyrinogen oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56171", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10930", "l": "ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625188", "l": "HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249378", "l": "STING recruits TBK1 and STAT6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59212", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP = AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33351", "l": "hexacosanoyl-CoA + sphinganine = CoA + H(+) + N-hexacosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667657", "l": "NBEA binds NICD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25422", "l": "3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate => 3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18478", "l": "2,3-dihydroxybenzoate + O2 => 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37283", "l": "H2O + L-alanyl-L-histidine = L-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51229", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate => 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694421", "l": "PP6 dephosphorylates SEC24 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177926", "l": "Dephosphorylation of PAG by SHP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61052", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043726", "l": "5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity", "d": ["Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19245", "l": "N-phenylhydroxylamine = 2-aminophenol", "d": [], "t": []}, {"i": "EC:5.4.4.1", "l": "\"(hydroxyamino)benzene mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59513", "l": "acetylsalicylate + L-seryl-[protein] => O-acetyl-L-seryl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-532549", "l": "MPI isomerises Fru6P to Man6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204303", "l": "MRE11 binds cytosolic DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874079", "l": "PTK2 binds activated MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254251", "l": "ERBB4s80 binds YAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875531", "l": "MET binds TNS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019776", "l": "Atg8-family ligase activity", "d": ["Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 family modifer to phosphatidylethanolamine or phosphatidylserine on a membrane."], "t": []}, {"i": "REACT:R-HSA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2250301", "l": "Formation of lysyl-pyrrole cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0019966", "l": "interleukin-1 binding", "d": ["Binding to interleukin-1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56306", "l": "21-phosphorifampicin + AMP + 2 H(+) + phosphate => ATP + H2O + rifampicin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33629", "l": "AMP + decanoyl-CoA + diphosphate => ATP + CoA + decanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20697", "l": "2 H(+) + 2 superoxide => H2O2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001161", "l": "intronic transcription regulatory region sequence-specific DNA binding", "d": ["Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63549", "l": "angiotensin-(1-9) + H2O => angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33378", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH <=> a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432946", "l": "PARVB/Affixin interacts with alpha PIX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.47", "l": "\"glucose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37316", "l": "glycyl-L-glutamine + H2O => glycine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37665", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16507", "l": "4-hydroxybenzoate + pyruvate => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450533", "l": "PKCdelta phosphorylates HuR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20095", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP => an anthocyanidin + H(+) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31078", "l": "(3S)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673761", "l": "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3209165", "l": "ID1 sequesters ETS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68911", "l": "ATP + H(+) + NADPH + picolinate <=> AMP + diphosphate + NADP(+) + picolinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55980", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O = an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.20", "l": "\"acyl-CoA:acyl-CoA alkyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607753", "l": "CARD9 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21500", "l": "UDP-alpha-D-glucose = H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}, {"i": "EC:4.2.1.76", "l": "\"UDP-glucose 4,6-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61788", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan = AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.73", "l": "\"L-tryptophan--[L-tryptophyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54094", "l": "2,4,5-trihydroxyphenylacetate + H2O + NADP(+) => 3,4-dihydroxyphenylacetate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22815", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methenyltetrahydrofolate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174070", "l": "Association of Cdh1 with the APC/C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421452", "l": "2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047255", "l": "galactogen 6-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11308", "l": "acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.2", "l": "\"acetyl-CoA carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63680", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43602", "l": "3R-hydroxyeicosanoyl-[ACP] + NADP(+) => 3-oxoeicosanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54268", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.30", "l": "\"hypoxia-inducible factor-asparagine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0031739", "l": "cholecystokinin receptor binding", "d": ["Binding to a cholecystokinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236970", "l": "Proteasomal clevage of exogenous antigen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140306", "l": "lipoprotein releasing activity", "d": ["The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18878", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77456", "l": "formylthiophene + hydrogen cyanide => (2R)-2-hydroxy-2-(thiophen-2-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46802", "l": "Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25481", "l": "acetoacetate + succinyl-CoA => acetoacetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.5", "l": "\"bacterial ABC-type protein transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.876091073600094", "identifiers": [{"i": "GO:0008378", "l": "galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}, {"i": "REACT:R-HSA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.140", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32087", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate = [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.98", "l": "\"Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6790038", "l": "Expression of HSP90B1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48748", "l": "D-threitol + NAD(+) = D-erythrulose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.403", "l": "\"D-threitol dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.371", "l": "\"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69095", "l": "H2O + NAD(+) + pentanal <=> 2 H(+) + NADH + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37690", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75373", "l": "guanosine(out) => guanosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12610", "l": "mercaptopurine + S-adenosyl-L-methionine => 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30315", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 = 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9770119", "l": "Formation of the Spliceosomal E complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16672", "l": "H2O + NAD(+) + xanthine <=> H(+) + NADH + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021609", "l": "ESR-associated SRC autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211219", "l": "Translocation of caspase-3 to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60770", "l": "3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A12 + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649735", "l": "Intrinsic nucleotide exchange on RAS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22615", "l": "(3S)-citramalyl-CoA <=> acetyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42388", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14058", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid => a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449829", "l": "IL11 binds IL11RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54339", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50940", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": [], "t": []}, {"i": "EC:2.3.2.20", "l": "\"cyclo(L-leucyl-L-phenylalanyl) synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2317332", "l": "PIP3 recruits AKT to the membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44265", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641205", "l": "RSPO:LGR binds ZNRF3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45000", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626549", "l": "IQGAPs bind CALM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19221", "l": "2 formaldehyde + H2O = formate + H(+) + methanol", "d": [], "t": []}, {"i": "EC:1.2.98.1", "l": "\"formaldehyde dismutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38720", "l": "(R)-carnitine(out) + ATP + H2O => (R)-carnitine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10883", "l": "7-methylxanthosine + H2O <=> 7-methylxanthine + D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1484099", "l": "MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29627", "l": "alpha-maltohexaose + beta-maltose = alpha-maltoheptaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52564", "l": "2-dehydro-L-erythronate = 3-dehydro-L-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484822", "l": "Kinetochore assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964851", "l": "Dehydratation of DHQ yields DHS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40433", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58175", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> beta-pinacene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432520", "l": "CLK:CYC heterodimer binds to cwo gene and activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943279", "l": "GGT dimers hydrolyse GSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379387", "l": "COMT transfers Met to DA to form 3MT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66156", "l": "butanoyl-CoA + tyramine = CoA + H(+) + N-butanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56967", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70736", "l": "chloride(out) + glycine betaine(out) + 2 Na(+)(out) => chloride(in) + glycine betaine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74140", "l": "petunidin + UDP-alpha-D-glucose => petunidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171291", "l": "Folding and Oligomerization of ENV glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030884", "l": "exogenous lipid antigen binding", "d": ["Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63688", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41413", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45059", "l": "deoxynogalonate + O2 <=> H(+) + H2O + nogalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55379", "l": "2 a quinol + O2 <=> 2 a quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28675", "l": "alpha-D-galactose = beta-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51764", "l": "dimethylallyl diphosphate + phlorisovalerophenone = 4-prenylphlorisovalerophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390276", "l": "4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15096", "l": "2-oxoglutarate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23302", "l": "(2Z,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36187", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49151", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634861", "l": "NPAS4 binds ARNT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38972", "l": "O2 + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77200", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxy-5-cholenate => 3beta-sulfo-5-cholenate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851064", "l": "AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11682", "l": "AMP + diphosphate + GMP + 2 H(+) + L-glutamate => ATP + H2O + L-glutamine + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.24", "l": "\"1,4-alpha-glucan 6-alpha-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035175", "l": "histone H3S10 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450088", "l": "GLUT1 tetramer binds 4xATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103015", "l": "4-amino-4-deoxy-L-arabinose transferase activity", "d": ["Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56503", "l": "(R)-3,5-bisphosphomevalonate + H(+) <=> CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853309", "l": "Autocatalytic phosphorylation of FGFR3 fusions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015319", "l": "sodium:inorganic phosphate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592297", "l": "Full activation of MMP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69074", "l": "Formation of Processive Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.-", "l": "\"CoA-transferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18290", "l": "(S,S)-tartrate => H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71987", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64118", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38630", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428273", "l": "SPHK1 phosphorylates sphingoid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40110", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12060", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42532", "l": "uridine(55) in tRNA = pseudouridine(55) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.25", "l": "\"tRNA pseudouridine(55) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673284", "l": "GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21307", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76651", "l": "3-methylbutanal + H2O + NADP(+) = 3-methylbutanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67169", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine => 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008783", "l": "agmatinase activity", "d": ["Catalysis of the reaction: agmatine + H2O = putrescine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51184", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O = H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53662", "l": "(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47056", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46555", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11863", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805640", "l": "AKT phosphorylates KAT6A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0034604", "l": "pyruvate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33049", "l": "(+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132061", "l": "Complement factor B binds to surface-bound C3b fragment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17033", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.56", "l": "\"cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625101", "l": "FOXO1 and SIN3A:HDAC complex bind GCK gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706393", "l": "RHOBTB3 binds ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74508", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197690", "l": "Detachment of WASP/WAVE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75103", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034569", "l": "monodemethylisoproturon dehydrogenase activity", "d": ["Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63778", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682377", "l": "LC3 de-lipidation by ATG4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71111", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) = L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62962", "l": "7-dehydrocholesterol(out) => 7-dehydrocholesterol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373734", "l": "Nephrin interacts with Podocin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22348", "l": "4-aminoimidazole + H(+) + H2O = imidazol-4-one + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.8", "l": "\"aminoimidazolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050104", "l": "L-gulonate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19147", "l": "D-glucose + H(+) + sulfate => D-glucose 6-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40438", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57201", "l": "glyoxal + L-arginyl-[protein] => N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008794", "l": "arsenate reductase (glutaredoxin) activity", "d": ["Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36759", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.306", "l": "\"UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22682", "l": "dUTP + NH4(+) => dCTP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031825", "l": "type 1F serotonin receptor binding", "d": ["Binding to a type 1F serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69449", "l": "(2E,6E)-farnesyl diphosphate + H2O => delta-cadinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41189", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31298", "l": "(2E)-2-hydroxypenta-2,4-dienoate <=> 2-oxopent-4-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562564", "l": "Caspase-8 processing within TLR4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983422", "l": "Disassembly of COPII coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61761", "l": "rebaudioside B + UDP-alpha-D-glucose => rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51381", "l": "(9Z)-octadecenoyl-CoA + dopamine => CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086076", "l": "gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395764", "l": "atREs binds to nascent CM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380234", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0019196", "l": "galactosamine transmembrane transporter activity", "d": ["Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678925", "l": "NR3C1 binds NR3C1 agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40742", "l": "(20S)-ginsenoside Rb2 + 2 H2O <=> (20S)-ginsenoside C-Y + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44078", "l": "AMP + diphosphate + pentadecanoyl-CoA => ATP + CoA + pentadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604722", "l": "Activation of proMMP9 by proteases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17463", "l": "D-sedoheptulose 7-phosphate + phosphate => D-sedoheptulose 1,7-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21672", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.100", "l": "\"protein-S-isoprenylcysteine O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46268", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650165", "l": "ASIC trimers bind H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15537", "l": "(2R)-3-sulfolactate + NADP(+) = 3-sulfopyruvate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.338", "l": "\"(2R)-3-sulfolactate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20049", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": [], "t": []}, {"i": "EC:3.5.4.19", "l": "\"phosphoribosyl-AMP cyclohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67014", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15935", "l": "(S)-lactaldehyde + H(+) + NADH => (S)-propane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14387", "l": "a dolichyl phosphate + H(+) + phosphate => a dolichyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13124", "l": "ATP + shikimate <=> 3-phosphoshikimate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29654", "l": "agmatine(in) + L-arginine(out) <=> agmatine(out) + L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71174", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) <=> H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674531", "l": "AAMP binds EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010176", "l": "homogentisate phytyltransferase activity", "d": ["Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57500", "l": "3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696491", "l": "CNTF binds CNTFR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53250", "l": "7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10978", "l": "5,6-dihydroquinoline-2,5,6-triol + NAD(+) => H(+) + NADH + O2 + quinolin-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033229", "l": "cysteine transmembrane transporter activity", "d": ["Enables the transfer of cysteine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31909", "l": "(S)-coclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-norcoclaurine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015315", "l": "organophosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990838", "l": "poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends", "d": ["Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72271", "l": "formate(out) + oxalate(in) = formate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350598", "l": "Arginine<=>Agmatine+CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68483", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) <=> CO2 + H2O + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174224", "l": "Dissociation of Cdc20 from APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64278", "l": "chrysophanol + H2O => chrysophanol-9-anthrone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49345", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75764", "l": "(9E,11E)-octadecadienoate + H2O => 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.490486312819655", "identifiers": [{"i": "GO:0016641", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31561", "l": "H(+) + L-galactono-1,4-lactone + NADH => L-galactose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114284", "l": "Release of Cytochrome c from mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14093", "l": "2-oxoglutarate + L-tryptophan = indole-3-pyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.27", "l": "\"tryptophan transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16876", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858489", "l": "ppDVL binds DAAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39779", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45655", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392834", "l": "Activation of EPACs by cAMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16459", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017108", "l": "5'-flap endonuclease activity", "d": ["Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685953", "l": "SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14458", "l": "glyoxylate + H2O + pentanoyl-CoA => 3-propylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450387", "l": "HuR binds the CRM1 nuclear export machinery (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70359", "l": "3-oxosphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16898", "l": "a 3beta-hydroxysteroid + a triacylglycerol => a 3beta-hydroxysteroid ester + a diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018589", "l": "di-n-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22488", "l": "S-(hydroxymethyl)glutathione = formaldehyde + glutathione", "d": [], "t": []}, {"i": "EC:4.4.1.22", "l": "\"S-(hydroxymethyl)glutathione synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11495", "l": "H(+) + O-phospho-L-threonine <=> (R)-1-aminopropan-2-yl phosphate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72259", "l": "L-dopa + S-adenosyl-L-methionine = 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28143", "l": "H2O + streptothricin D => streptothricin D acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72121", "l": "(R)-carnitine(out) + glycine betaine(in) => (R)-carnitine(in) + glycine betaine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688834", "l": "ATXN3 binds VCP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354060", "l": "Translocation of RIAM to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15943", "l": "acetate + L-ornithine => H2O + N(2)-acetyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18741", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.166", "l": "\"2alpha-hydroxytaxane 2-O-benzoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71526", "l": "adenine(out) <=> adenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964284", "l": "BTK in active Gq-BTK complex is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44229", "l": "9-decenoate + ATP + CoA => 9-decenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662606", "l": "MT3 binds zinc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004753", "l": "saccharopine dehydrogenase activity", "d": ["Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50991", "l": "prostaglandin F2alpha(out) <=> prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450551", "l": "AUF1 binds translation and heat shock proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50101", "l": "dodecanoyl-CoA + taurine => CoA + H(+) + N-dodecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004573", "l": "Glc3Man9GlcNAc2 oligosaccharide glucosidase activity", "d": ["Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14389", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.149", "l": "\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788611", "l": "HYKK phosphorylates 5HLYS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31882", "l": "(S)-2,3-epoxysqualene <=> beta-seco-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080078", "l": "tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24986", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin] => (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35049", "l": "AMP + H2O + Mo-molybdopterin => adenylyl-molybdopterin + H(+) + molybdate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70705", "l": "D-cycloserine(out) + H(+)(out) => D-cycloserine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60272", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75246", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40300", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43479", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64915", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68275", "l": "a fatty acyl-CoA + L-seryl-[protein] <=> CoA + O-fatty acyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.83", "l": "\"monoterpene epsilon-lactone hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627737", "l": "SLC26A3 does not exchange Cl- for HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70608", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol => 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49576", "l": "AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:4.1.99.22", "l": "\"GTP 3',8-cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047181", "l": "tetrahydroxybenzophenone synthase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682020", "l": "MRN complex binds shortened telomeres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004453", "l": "juvenile-hormone esterase activity", "d": ["Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63483", "l": "NADP(+) + prostaglandin F2alpha <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430311", "l": "Rsu-1 interacts with Pinch1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46357", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] => 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56662", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30437", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.18", "l": "\"pancreatic ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781953", "l": "YOD1 binds VCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52251", "l": "6 H2O + 4 Mn(3+) + O2 <=> 12 H(+) + 4 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0043047", "l": "single-stranded telomeric DNA binding", "d": ["Binding to single-stranded telomere-associated DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77423", "l": "cyclohexanecarbaldehyde + hydrogen cyanide = (2S)-2-cyclohexyl-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701064", "l": "TRPV1 binds TRPV1 agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21869", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O => 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004964", "l": "luteinizing hormone receptor activity", "d": ["Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26312", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30024", "l": "L-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874082", "l": "MET phosphorylates PTK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981892", "l": "Active G alpha (z) binds RGS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16409", "l": "1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine", "d": [], "t": []}, {"i": "EC:1.5.1.32", "l": "\"vomilenine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59132", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP = AMP + diphosphate + H(+) + staphyloferrin B", "d": [], "t": []}, {"i": "EC:6.3.2.56", "l": "\"staphyloferrin B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877187", "l": "P2X7 mediates loss of intracellular K+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173626", "l": "Activation of C1r (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32135", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74825", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848774", "l": "PTK6 binds DOK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909765", "l": "Mitochondrial uptake of beta-alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097003", "l": "adipokinetic hormone receptor activity", "d": ["Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44128", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24019", "l": "16-epivellosimine + acetyl-CoA <=> CoA + vinorine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73578", "l": "(E,E)-piperate + ATP + H(+) <=> (E,E)-piperoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54760", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide = 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847534", "l": "RAB43 hydrolyses GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.50", "l": "\"pentachlorophenol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.35", "l": "\"histolysain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863494", "l": "ASICs bind STOML3, (STOM) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15351", "l": "L-ornithine + N-acetyl-L-glutamate => L-glutamate + N(2)-acetyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102368", "l": "beta-amyrin 30-monooxygenase activity", "d": ["Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 = 30-hydroxy-beta-amyrin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082391", "l": "Trimerization of HSF1 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53615", "l": "CTP + D-ribulose 5-phosphate + H(+) <=> CDP-D-ribulose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70465", "l": "a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448963", "l": "Interaction of MyoD:E protein with MEF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374896", "l": "Uptake of Noradrenaline (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954082", "l": "E2F6 binds the PRC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16063", "l": "choline + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2265534", "l": "Defective GLB1 does not hydrolyse a glycosaminoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989777", "l": "Expression of RGL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35185", "l": "4-carboxy-2-thioxobutanoyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050254", "l": "rhodopsin kinase activity", "d": ["Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433415", "l": "Activation of RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23204", "l": "chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate", "d": [], "t": []}, {"i": "EC:2.3.1.98", "l": "\"chlorogenate--glucarate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174444", "l": "Formation of C-strand Okazaki fragments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72153", "l": "estrone 3-sulfate(in) + glutarate(out) => estrone 3-sulfate(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961888", "l": "E2F1 binds the CCNA1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.28", "l": "\"phenylsuccinyl-CoA transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408509", "l": "Sec-tRNA(Sec) binds to EEFSEC:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191763", "l": "snRNP:Snurportin complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30509", "l": "2-demethylmenaquinol-8 + NAD(+) => 2-demethylmenaquinone-8 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28920", "l": "4-aminobutanoate(in) + L-glutamate(out) => 4-aminobutanoate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369028", "l": "ABCAs mediate lipid efflux (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.20", "l": "\"cathepsin G\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419351", "l": "PAF receptor binds platelet activating factor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50225", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71638", "l": "phosphate(in) + 2 thiosulfate(out) <=> phosphate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75081", "l": "Formation of AT-AC B Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47897", "l": "6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24193", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34416", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 => (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.211", "l": "\"endo-(1->3)-fucoidanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77159", "l": "H2O + selenophosphate + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-1-seleno-beta-D-glucosamine + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112037", "l": "Inactivation of PLC beta (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211387", "l": "Anthrax lef cleaves target cell MAP2K7 (MEK7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56267", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65386", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.126200859969501", "identifiers": [{"i": "GO:0015157", "l": "oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of oligosaccharide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390597", "l": "Release Of ADP From Myosin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.-", "l": "\"Phosphorus-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27577", "l": "(3R)-piperidine-3-carboxamide + H2O <=> (3R)-piperidine-3-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53434", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23762", "l": "reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990407", "l": "calcitonin gene-related peptide binding", "d": ["Binding to calcitonin gene-related peptide (CGRP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26346", "l": "L-galactonate + NADP(+) => aldehydo-D-galacturonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65111", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] <=> aculene A + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76750", "l": "hexadecane + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hexadecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714483", "l": "RAC2 translocates to the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48388", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60817", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 => CO2 + gibberellin A14 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730856", "l": "Autophosphorylation of PAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873850", "l": "STARD5 binds DCA, LCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58995", "l": "(E)-cinnamaldehyde + H2O + O2 <=> (E)-cinnamate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004039", "l": "allophanate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 3 H+ + urea-1-carboxylate = 2 CO2 + 2 NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102702", "l": "2-carene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (+)-2-carene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9619355", "l": "CaMKK autophosphorylates in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}, {"i": "EC:1.13.11.40", "l": "\"arachidonate 8-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14894", "l": "D-ornithine => (2R,4S)-2,4-diaminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61698", "l": "AMP + diphosphate + glycyl-[peptidyl-carrier protein] => ATP + glycine + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863727", "l": "STON2 is neddylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40297", "l": "AMP + diphosphate + hexadecanedioyl-CoA => ATP + CoA + hexadecanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.28", "l": "\"tropomyosin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32680", "l": "(2E)-geranyl diphosphate + H2O => (2E)-geraniol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9703895", "l": "CASR binds CASR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38086", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070040", "l": "rRNA (adenine(2503)-C2-)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76739", "l": "dodecane + O2 + reduced [NADPH--hemoprotein reductase] = 5-dodecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15940", "l": "a primary alcohol + NADP(+) <=> an aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001221", "l": "transcription coregulator binding", "d": ["Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65669", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352268", "l": "Cleavage of Satb1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71435", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) = an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26544", "l": "(R)-piperazine-2-carboxylate + NH4(+) => (R)-piperazine-2-carboxamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18421", "l": "acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.28", "l": "\"chloramphenicol O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49185", "l": "chlorophyllide a + H(+) + H2O => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0004596", "l": "peptide alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.-", "l": "\"Transferring groups other than amino-acyl groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22471", "l": "GTP + 3 H2O <=> 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-593685", "l": "Netrin-4 binds DCC/UNC5A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45802", "l": "10-decarboxymethylaclacinomycin T + A + CO2 + H2O => 15-demethylaclacinomycin T + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.255", "l": "\"N-terminal amino-acid N(alpha)-acetyltransferase NatA\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187506", "l": "Translocation of p27 to the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67439", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55803", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49486", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802921", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20641", "l": "H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.23", "l": "\"histidinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29432", "l": "ATP + phosphate => ADP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66623", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65738", "l": "CO2 + H(+) + octanal + succinate + sulfate => 2-oxoglutarate + O2 + octyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38796", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32991", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11953", "l": "3-hydroxypyruvate => 2-hydroxy-3-oxopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55250", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950778", "l": "p-Y693-STAT4 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61510", "l": "peonidin 3-O-beta-D-glucoside + UDP => peonidin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67053", "l": "AH2 + asnovolin J + O2 => A + asnovolin A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052729", "l": "dimethylglycine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17955", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => 3-hydroxyanthranilate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69069", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868071", "l": "Clathrin recruits PIK3C2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805109", "l": "CDK2 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30088", "l": "(S)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177942", "l": "EGFR binds EGF ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21154", "l": "cis-4-hydroxy-D-proline => trans-4-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44667", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0010011", "l": "auxin binding", "d": ["Binding to auxin, a plant hormone that regulates aspects of plant growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38873", "l": "pseudouridine(2457) in 23S rRNA => uridine(2457) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853801", "l": "PSPN binds RET:GFRA4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004076", "l": "biotin synthase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0043130", "l": "ubiquitin binding", "d": ["Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1901239", "l": "malonate(1-) transmembrane transporter activity", "d": ["Enables the transfer of malonate(1-) from one side of a membrane to the other."], "t": []}, {"i": "RHEA:33115", "l": "malonate(in) = malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25762", "l": "ent-copalyl diphosphate <=> diphosphate + ent-isokaurene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37016", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592362", "l": "Activation of proMMP7 by MMP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250606", "l": "botD LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033238", "l": "PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48214", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28234", "l": "L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10760", "l": "citrate = acetate + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.1.3.6", "l": "\"citrate (pro-3S)-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39236", "l": "(3R)-hydroxytriacontanoyl-CoA => (2E)-triacontenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69776", "l": "(2E,6E)-farnesyl diphosphate => beta-ylangene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74939", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 = a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68399", "l": "a percarboxylic acid + H2O <=> a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10197", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51021", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] => an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57736", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol = AH2 + all-trans-3,4-didehydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58773", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46436", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236935", "l": "Proteasomal cleavage of substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28207", "l": "2'-deoxyuridine + ATP => ADP + dUMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551297", "l": "Defective ALG11 does not transfer Man to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008086", "l": "light-activated voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70724", "l": "sitosterol(out) => sitosterol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050597", "l": "taxane 10-beta-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211191", "l": "Association of DFF with alpha:beta importin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71204", "l": "L-homoarginine(in) => L-homoarginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71346", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) <=> chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53454", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33559", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.198", "l": "\"glycerol-3-phosphate 2-O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388809", "l": "CTLA-4 binds B7-1/B7-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67867", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16776", "l": "a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose <=> a ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35585", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13694", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047506", "l": "(deoxy)adenylate kinase activity", "d": ["Catalysis of the reaction: ATP + dAMP = ADP + dADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209823", "l": "Tyrosine is hydroxylated to dopa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050346", "l": "trans-L-3-hydroxyproline dehydratase activity", "d": ["Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32190", "l": "cholest-5-en-3-one <=> cholest-4-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814409", "l": "CK2 phosphorylates PDCL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374173", "l": "AGT(34-41) binds to AGTR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39609", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863494", "l": "ASICs bind STOML3, (STOM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32373", "l": "all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate => all-trans-violaxanthin + 2 L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34249", "l": "1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH => 1-deoxymethyl-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52993", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine => [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0160012", "l": "NAD-dependent histone decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71385", "l": "L-asparagine(out) + Na(+)(out) => L-asparagine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37201", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50781", "l": "NADP(+) + octanal => (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77706", "l": "a ganglioside GA1 (d18:1(4E)) + GDP-beta-L-fucose <=> a ganglioside Fuc-GA1 (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704248", "l": "CHRM4 binds CHRM4 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72691", "l": "Formation of the 43S pre-initiation complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657637", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51350", "l": "10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine => acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58401", "l": "heptan-1-ol + NADP(+) => H(+) + heptanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661230", "l": "MT1A binds arsenic (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10016", "l": "H2O + O-sinapoylcholine = (E)-sinapate + choline + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.49", "l": "\"sinapine esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68078", "l": "a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16312", "l": "H2O + taurochenodeoxycholate <=> chenodeoxycholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13914", "l": "L-threonine => D-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20087", "l": "a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 3-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791076", "l": "Expression of ADD1 (Adducin alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64904", "l": "GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0015562", "l": "efflux transmembrane transporter activity", "d": ["Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37942", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35729", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + CoA => dodecanoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61230", "l": "3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+) => H2O + L-histidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824280", "l": "MSGN1 binds the DLL3 gene in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21917", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O => an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41415", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24945", "l": "(4S)-4-hydroxy-L-glutamate + H(+) + NADPH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62663", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol <=> (2'R)-atrovenetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33501", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 => H(+) + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34191", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17034", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl-2,3-diol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205286", "l": "GRB2:SOS interacts with p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602466", "l": "Activation of MT-MMPs by FURIN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0018551", "l": "dissimilatory sulfite reductase activity", "d": ["Catalysis of the reactions: [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H+ + sulfite and [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H+ + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102157", "l": "(R)-sulfopropanediol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD = 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375138", "l": "CDO binds BOC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228992", "l": "ROCK1,ROCK2 are activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36288", "l": "H(+) + NADPH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51750", "l": "4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54378", "l": "diphosphate + nezukol => (+)-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64941", "l": "dGDP + H2O => dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60069", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58264", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000823", "l": "inositol-1,4,5-trisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + 2 ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + 2 ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380930", "l": "Phosphorylated AMPK binds AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647660", "l": "GSDME (1-270) binds PIPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68169", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660660", "l": "p300 acetylates RELA subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60237", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944240", "l": "Association of procollagen type III (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9844955", "l": "CLN3 transports GalCer to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42464", "l": "biphenyl-2,2',3-triol + O2 = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71993", "l": "(-)-astellatene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73599", "l": "CDP(in) + CTP(out) = CDP(out) + CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12541", "l": "ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48442", "l": "a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15059", "l": "(9Z)-octadecenoate + H(+) + holo-[ACP] => (9Z)-octadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58160", "l": "ent-copalyl diphosphate = diphosphate + dolabradiene", "d": [], "t": []}, {"i": "EC:4.2.3.196", "l": "\"dolabradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23046", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373738", "l": "Neurofascin interacts with syntenin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350578", "l": "NQO1 interaction with ODC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14133", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.103", "l": "\"tabersonine 16-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418172", "l": "F2R binds ARRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72127", "l": "agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66251", "l": "CoA + IC-asc-C9-AMP <=> AMP + H(+) + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016015", "l": "morphogen activity", "d": ["Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49035", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48445", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30781", "l": "2-dehydro-D-gluconate + FADH2 => D-gluconate + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296043", "l": "Activation of HCN channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604722", "l": "Activation of proMMP9 by proteases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114552", "l": "Thrombin-activated PARs activate G12/13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24722", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 = H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863727", "l": "STON2 is neddylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50687", "l": "H2O + N(5)-phenyl-L-glutamine <=> aniline + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156699", "l": "Inactivation of Wee1 kinase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051786", "l": "all-trans-retinol 13,14-reductase activity", "d": ["Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69817", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => cathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70153", "l": "6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048040", "l": "UDP-glucuronate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209165", "l": "ID1 sequesters ETS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65533", "l": "2-methylbutan-1-ol + hexanoyl-CoA => 2-methylbutyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15263", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15510", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22820", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.62", "l": "\"xylosyl alpha-1,3-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21394", "l": "2-phenylacetate + 2 H(+) + NADH => 2-phenylacetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11351", "l": "arsenite(in) + ATP + H2O <=> ADP + arsenite(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097077", "l": "copper ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.133", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033476", "l": "Dimerization of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167429", "l": "The receptor:G-protein complex  binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672980", "l": "Dissociation of RAS:RAF complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77515", "l": "3-methoxybenzaldehyde + hydrogen cyanide = (2S)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322135", "l": "Defective MMAA does not protect MUT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29203", "l": "dimethyl sulfoxide + menaquinol-8 = dimethyl sulfide + H2O + menaquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24526", "l": "5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68954", "l": "Mcm2-7 is phosphorylated by DDK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74535", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205238", "l": "SHP2 interacts with p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466764", "l": "NRPE condenses with atRAL to form A2PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77488", "l": "4-methylpentan-2-one + hydrogen cyanide => (2S)-2-hydroxy-2,4-dimethylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58549", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24416", "l": "2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.41", "l": "\"2,4'-dihydroxyacetophenone dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202137", "l": "AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10085", "l": "3,4-dihydroxybenzoate + O2 => 3-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19247", "l": "2-aminophenol => N-phenylhydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726949", "l": "PTGIR binds PTGIR agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75461", "l": "(9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047603", "l": "acetoacetyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: acetoacetyl-CoA + H2O = acetoacetate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858252", "l": "HDLBP binds HDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35810", "l": "2-dehydro-3-deoxy-D-arabinonate <=> 2,5-dioxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74798", "l": "N-methyl-(R)-salsolinol(in) <=> N-methyl-(R)-salsolinol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54430", "l": "ADP-D-ribose + H(+) + L-aspartyl-[protein] => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180606", "l": "Association of Vpu with CD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45060", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.11", "l": "\"2-haloacid dehalogenase (configuration-retaining)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.2", "l": "\"ABC-type Cd(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75474", "l": "thiamine diphosphate(out) <=> thiamine diphosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25286", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55783", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63465", "l": "(2E,6E,10E)-geranylgeraniol + UTP => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202164", "l": "Translocation of PDK1 to Plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73930", "l": "griseophenone D + S-adenosyl-L-methionine <=> griseophenone C + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106615", "l": "Removal of siRNA passenger strand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047145", "l": "demethylsterigmatocystin 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54099", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58164", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.197", "l": "\"eudesmane-5,11-diol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31460", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800793", "l": "PIDD1 translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41306", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40160", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032770", "l": "Translocation of YAP1 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046547", "l": "trans-aconitate 3-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61739", "l": "steviolmonoside + UDP-alpha-D-glucose <=> rubusoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700120", "l": "PTN and MDK bind to PTPRZ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38876", "l": "uridine(2604) in 23S rRNA => pseudouridine(2604) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14132", "l": "cholate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62528", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53227", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380177", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31630", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine <=> 10-deoxymethymycin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75172", "l": "Formation of RAD50:MRE11 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008469", "l": "histone arginine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31512", "l": "chenodeoxycholoyl-CoA + H2O => chenodeoxycholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57822", "l": "[phosphate](n+1) + AMP => [phosphate](n) + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46049", "l": "D-galactosamine 6-phosphate => alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18193", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52193", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41898", "l": "NADP(+) + tetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004021", "l": "L-alanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682258", "l": "nsp14 binds nsp12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627078", "l": "XIAP binds CASP9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.33", "l": "\"4-hydroxybenzoate 3-monooxygenase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32234", "l": "(6S)-NADPHX + ATP <=> ADP + H(+) + NADPH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18786", "l": "A + gibberellin A12 aldehyde + H2O => AH2 + gibberellin A12 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48461", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23271", "l": "guanidinoacetate + H2O <=> glycine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733973", "l": "Bile salts bind FABP6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58048", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA = 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51137", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34235", "l": "4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37399", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990055", "l": "phenylacetaldehyde synthase activity", "d": ["Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.28", "l": "\"2-phospho-L-lactate transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54260", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018849", "l": "muconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49106", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester => Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51972", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449058", "l": "Interleukin-1 family are secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60017", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033874", "l": "scymnol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40617", "l": "2,3-didecanoyl-sn-glycerol + decanoate + H(+) => H2O + tridecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53622", "l": "(-)-spiroviolene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56495", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41778", "l": "CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681375", "l": "KIT binds ripretinib (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46025", "l": "H2O2 + tetradecanoate => (3R)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683925", "l": "ULK1 is dephosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10251", "l": "dUTP + H2O <=> diphosphate + dUMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63915", "l": "6-azauridine + ATP <=> 6-azauridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77388", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51914", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59916", "l": "(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45277", "l": "12-phosphooxy-(9E)-octadecenoate + H2O => 12-hydroxy-(9E)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46382", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57237", "l": "GMP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42180", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43564", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine = [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.108", "l": "\"(5-formylfuran-3-yl)methyl phosphate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57340", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031962", "l": "nuclear mineralocorticoid receptor binding", "d": ["Binding to a nuclear mineralocorticoid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66061", "l": "2-oxohexanoate + L-kynurenine => H2O + kynurenate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38177", "l": "all-trans-retinyl hexadecanoate + CoA => all-trans-retinol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58742", "l": "diphosphate + H(+) + psi-UMP => H2O + psi-UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50804", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21926", "l": "2,3-dioxo-L-gulonate + H(+) + NADH => 3-dehydro-L-gulonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14510", "l": "2-oxoglutarate + mugineate + O2 => 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12889", "l": "L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.45", "l": "\"L-gulonate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13819", "l": "2,3-epoxyphylloquinone + [protein]-dithiol => [protein]-disulfide + H2O + phylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41403", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004610", "l": "phosphoacetylglucosamine mutase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879930", "l": "STAT5 is recruited by JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55091", "l": "eburicol + S-adenosyl-L-methionine <=> (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856189", "l": "TNFSF8 binds TNFRSF8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112510", "l": "IL6ST is tyrosine phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19815", "l": "2-oxosuccinamate + an L-alpha-amino acid => a 2-oxocarboxylate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74182", "l": "a secondary alkyl amine + H2O + NADP(+) <=> a ketone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24285", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate => 4-phospho-L-aspartate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761822", "l": "NFE2L2 binds the IDH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008768", "l": "UDP-sugar diphosphatase activity", "d": ["Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35627", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.238", "l": "\"delphinidin 3,5-di-O-glucoside 3'-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12502", "l": "3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH => (3R)-1,4-thiomorpholine-3-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218804", "l": "p38 MAPK activation by VEGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40238", "l": "coenzyme B + coenzyme M + fumarate <=> coenzyme M-coenzyme B heterodisulfide + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170149", "l": "Translocation of active Cdc25C to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77676", "l": "a globoside GalGb4Cer (d18:1(4E)) + H2O => an N-acylsphing-4-enine + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30122", "l": "dodecanoyl-[ACP] + H2O <=> dodecanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12741", "l": "ADP + H(+) + H2O = IDP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865994", "l": "GAB1 binds PTPN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38903", "l": "a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46680", "l": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": [], "t": []}, {"i": "EC:1.6.2.2", "l": "\"cytochrome-b5 reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28812", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) => 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26494", "l": "chloride + FADH2 + L-tryptophan + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.9", "l": "\"tryptophan 7-halogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28692", "l": "(S)-dihydroorotate + a ubiquinone => a ubiquinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562564", "l": "Caspase-8 processing within TLR4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0016211", "l": "ammonia ligase activity", "d": ["Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11075", "l": "anthranilate + 3 H(+) + NADPH + O2 <=> catechol + CO2 + NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37565", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15576", "l": "N-acetylserotonin + S-adenosyl-L-methionine <=> H(+) + melatonin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66896", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048502", "l": "ABC-type thiamine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H+ + phosphate + thiamine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68465", "l": "2-butyloctyl sulfate + H2O => 2-butyloctan-1-ol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109857", "l": "MAP2K1 binds MAPK3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46253", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30604", "l": "15-cis-phytoene + A => AH2 + all-trans-phytofluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56551", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784189", "l": "JAKs bind LIFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69127", "l": "Formation of the Flap Intermediate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17671", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933533", "l": "Dimerization of p-IRF7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27721", "l": "H2O + IMP <=> inosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74048", "l": "L-alanine(in) + L-valine(out) => L-alanine(out) + L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050301", "l": "streptomycin-6-phosphatase activity", "d": ["Catalysis of the reaction: H2O + streptomycin 6-phosphate = phosphate + streptomycin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120021", "l": "oxysterol transfer activity", "d": ["Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626938", "l": "Beta-catenin binds SOX proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.35", "l": "\"dimethylsulfone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56691", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 <=> (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62865", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72691", "l": "Formation of the 43S pre-initiation complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31799", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67810", "l": "H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine => L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55602", "l": "a mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12790", "l": "an alditol + NADP(+) => an aldose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396379", "l": "NOTCH1 Coactivator Complex binds HES5 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180728", "l": "Association of Ran-GTP with importin-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48140", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": [], "t": []}, {"i": "EC:1.14.15.17", "l": "\"pheophorbide a oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26116", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + epi-cedrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229283", "l": "LCNs bind lipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74064", "l": "2-aminoisobutanoate(out) + L-alanine(in) => 2-aminoisobutanoate(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090523", "l": "cytochrome-b5 reductase activity, acting on NADPH", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5)."], "t": []}, {"i": "RHEA:64576", "l": "2 Fe(III)-[cytochrome b5] + NADPH = 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828727", "l": "N mRNA is translated into protein N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655850", "l": "Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60484", "l": "CTP + UTP = cyclic CMP-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652165", "l": "MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507873", "l": "Aquaporins passively transport urea out of cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796209", "l": "Expression of FOXA2 in the anterior primitive streak (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43971", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0032217", "l": "riboflavin transmembrane transporter activity", "d": ["Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202703", "l": "CD47 binds SIRP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27824", "l": "acetate + L-homocysteine => hydrogen sulfide + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210439", "l": "glutamate uptake by astrocytes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13667", "l": "3',5'-cyclic GMP + diphosphate => GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73194", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA <=> (2R,3S,11R)-acetylaszonalenin + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49880", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848250", "l": "ACBD6 binds LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396370", "l": "VTN binds collagens II, III and V (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848873", "l": "PTK6 phosphorylates ARAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54311", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72697", "l": "Start codon recognition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44309", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928583", "l": "FYN phosphorylates NMDAR2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10713", "l": "L-phenylalanine + O2 => 2-phenylacetamide + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77218", "l": "dATP + H2O <=> 2-deoxyribose 5-triphosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0070643", "l": "vitamin D 25-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-25 of any form of vitamin D."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008893", "l": "guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity", "d": ["Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61425", "l": "cis-cis-nepetalactol + NAD(+) => cis-cis-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75244", "l": "FASL binds FAS Receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12118", "l": "AH2 => A + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48372", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45176", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52112", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240766", "l": "E2F1/2/3:DP1/2 binds SUZ12 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848930", "l": "PTK6 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27781", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) <=> 2-all-trans-octaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16094", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42859", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047064", "l": "sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity", "d": ["Catalysis of the reaction: O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109700", "l": "AKT2 binds PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622134", "l": "CRABP1 binds atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050167", "l": "pantothenoylcysteine decarboxylase activity", "d": ["Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H+ = (R)-pantetheine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938217", "l": "RUNX1 binds the SWI/SNF complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13762", "l": "L-methionine + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19849", "l": "H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12911", "l": "2 Fe(III)-[cytochrome] + H2O + nitrite => 2 Fe(II)-[cytochrome] + 2 H(+) + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18015", "l": "ethylamine + L-glutamate => H2O + N(5)-ethyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799761", "l": "TP53 binds PPP1R13L (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52571", "l": "epitestosterone + UDP-alpha-D-glucuronate <=> epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193703", "l": "IKKbeta is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48929", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11334", "l": "diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450187", "l": "TAK1 is activated within the TAK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374701", "l": "Phosphorylation of DCC by Fyn (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66254", "l": "AMP + diphosphate + IC-asc-C7-CoA => ATP + CoA + IC-asc-C7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323526", "l": "FRAT proteins bind GSK3beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002055", "l": "adenine binding", "d": ["Binding to adenine, a purine base."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35958", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B <=> 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20928", "l": "[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol", "d": [], "t": []}, {"i": "EC:1.8.5.9", "l": "\"protein dithiol:quinone oxidoreductase DsbB\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102838", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70224", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate => 2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684016", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57714", "l": "4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP => (E)-sinapaldehyde + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052610", "l": "beta-cryptoxanthin hydroxylase activity", "d": ["Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202127", "l": "eNOS synthesizes NO (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57730", "l": "CO2 + itaconate => H(+) + trans-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34992", "l": "L-arginine(out) + L-ornithine(in) => L-arginine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49116", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-919404", "l": "Phosphorylated STAT5 is released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434836", "l": "Syk/Lck phosphorylate LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424485", "l": "Release of p-PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018755", "l": "2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity", "d": ["Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67936", "l": "a 2-hydroxy carboxylate + O2 = a 2-oxocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58486", "l": "acetate + sphing-4-enine => H2O + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981680", "l": "C4b binding protein displaces C2a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15737", "l": "cyclopentanone + H(+) + NADPH + O2 = 5-valerolactone + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.16", "l": "\"cyclopentanone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71907", "l": "GDP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140346", "l": "phosphatidylserine flippase activity", "d": ["Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432510", "l": "CLK is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.775903698273282", "identifiers": [{"i": "GO:1904680", "l": "peptide transmembrane transporter activity", "d": ["Enables the transfer of a peptide from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-1500817", "l": "Glutathione is taken up by the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49191", "l": "a bacteriochlorophyllide d <=> a 3-vinylbacteriochlorophyllide d + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981637", "l": "Complement factor I inactivates C4BP-bound C4b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990846", "l": "ribonucleoside-diphosphate reductase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690669", "l": "CD22 binds itself to form homo-oligomers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42490", "l": "3'-N-debenzoyl-2'-deoxytaxol + CoA => (3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138432", "l": "DVL2 is phosphorylated by PKC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018594", "l": "MECP2 binds LBR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15093", "l": "2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031754", "l": "Edg-1 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-1 sphingosine 1-phosphate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218829", "l": "VEGF induces CDC42 activation by unknown mechanism (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965441", "l": "FZD recruits trimeric G-proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804379", "l": "PRMT5 binds TTC5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481010", "l": "Surface deployment of platelet dense granule membrane components (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57978", "l": "(20S)-ginsenoside C-K + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.54", "l": "\"mucrolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034482", "l": "chondroitin 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944246", "l": "Association of procollagen type XXI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57449", "l": "ATP + D-tyrosine + tRNA(Tyr) => AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22587", "l": "2 H(+) + heme b <=> Fe(2+) + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71716", "l": "H(+)(out) + L-leucyl-L-leucine(out) => H(+)(in) + L-leucyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106407", "l": "Glc2Man9GlcNAc2 oligosaccharide glucosidase activity", "d": ["Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H2O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012186", "l": "CHD1 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785213", "l": "LIPC dimer binds heparin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726949", "l": "PTGIR binds PTGIR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32028", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-cuprenene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34075", "l": "an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.275", "l": "\"acyl phosphate:glycerol-3-phosphate acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59921", "l": "(2E)-octenal + H2O + NAD(+) => (2E)-octenoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56278", "l": "3'-L-prolyl-AMP + diphosphate => ATP + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140805", "l": "NAD+-protein-serine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]."], "t": []}, {"i": "RHEA:58232", "l": "L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626914", "l": "α2-agonists bind ADRA2A,B,C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29079", "l": "(R)-lactate + ubiquinone-8 = pyruvate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13233", "l": "guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56889", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64620", "l": "(E)-sinapyl alcohol + acetyl-CoA = (E)-sinapoyl actetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34381", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937807", "l": "SRC phosphorylates RUNX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36932", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60719", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61206", "l": "H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein] => L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762343", "l": "PREDL:ALB dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48585", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64332", "l": "ATP + CoA + nicotinate = AMP + diphosphate + nicotinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169895", "l": "Crk's SH3 domain engages C3G (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59323", "l": "D-cellobiono-1,5-lactone + H2O <=> 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64956", "l": "dTTP + 2 H2O = dTMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41614", "l": "D-ribose 2,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354097", "l": "Activation of Talin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610653", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35154", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) <=> (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47021", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17401", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.83", "l": "\"4-oxalmesaconate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.135", "l": "\"galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29770", "l": "ATP + D-methionine(out) + H2O <=> ADP + D-methionine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16331", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75872", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421457", "l": "Mitochondrial uptake and processing of ALAS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692764", "l": "MAPK6 binds CCND3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14618", "l": "CoA + glutathione + NADP(+) => CoA-glutathione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13666", "l": "GTP => 3',5'-cyclic GMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015322", "l": "secondary active oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420977", "l": "Ca permeable AMPA receptor ligand binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050033", "l": "L-rhamnono-1,4-lactonase activity", "d": ["Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26424", "l": "adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate => 3'-phosphoadenylyl sulfate + thyroxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61675", "l": "ATP + H(+) + L-cysteine <=> diphosphate + L-cysteinyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58580", "l": "dihydroprecondylocarpine acetate = acetate + catharanthine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2301205", "l": "SETD8 monomethylates histone H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9842115", "l": "PSAP(195-273) dimer binds PE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847635", "l": "Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53513", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754130", "l": "CDK4 inhibitors bind CDK4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784620", "l": "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20614", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112755", "l": "SOCS3 binds IL6ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51915", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72697", "l": "Start codon recognition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050407", "l": "[glycogen-synthase-D] phosphatase activity", "d": ["Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44469", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917839", "l": "apo-Transferrin dissociates from the receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58707", "l": "rifampicin hemiaminal <=> rifampicin ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31832", "l": "(2E,6E)-farnesyl diphosphate => delta-guaiene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954082", "l": "E2F6 binds the PRC1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40123", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70791", "l": "H(+)(in) + L-ornithine(out) = H(+)(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68312", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O = 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48603", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O <=> [protein-PII]-L-tyrosine + H(+) + UMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18203", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047124", "l": "L-erythro-3,5-diaminohexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxo-hexanoate + H+ + NADH + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34549", "l": "ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031172", "l": "ornithine N5-monooxygenase activity", "d": ["Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30803", "l": "4-aminobutanal + H2O + NADP(+) = 4-aminobutanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166817", "l": "Cleavage of C3 by C3 convertases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36768", "l": "2-hydroxytetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.10", "l": "\"streptopain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71198", "l": "H(+)(out) + Zn(2+)(out) <=> H(+)(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002196", "l": "Ser-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10117", "l": "6-phospho-D-gluconate + NADP(+) => CO2 + D-ribulose 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23809", "l": "(S)-scoulerine + S-adenosyl-L-methionine => (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72256", "l": "dopamine + S-adenosyl-L-methionine => 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9671145", "l": "DKC1 binds SHQ1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050144", "l": "nucleoside deoxyribosyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61718", "l": "ADP + D-galactofuranose(in) + H(+) + phosphate => ATP + D-galactofuranose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73683", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358791", "l": "Phosphorylation of USP8 by P-AKT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54663", "l": "an aromatic (S)-hydroxynitrile <=> an aromatic aldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52448", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917987", "l": "TFRC dimer binds 2xholoTF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18550", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32763", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine = (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.59", "l": "\"3-methyl-D-ornithine--L-lysine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32701", "l": "beta-sesquiphellandrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60047", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77069", "l": "H(+) + NADPH + NH4(+) + pentanal => H2O + NADP(+) + pentylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0098879", "l": "structural constituent of postsynaptic specialization", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic specialization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50119", "l": "eicosanoyl-CoA + taurine <=> CoA + H(+) + N-eicosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75856", "l": "Abortive Initiation Before Second Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446364", "l": "Migfilin interacts with VASP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28412", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH => 4-(gamma-L-glutamylamino)butanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.12", "l": "\"Met-Xaa dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50071", "l": "ATP + glycoursodeoxycholate(in) + H2O <=> ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33569", "l": "acetaldehyde + AH2 => A + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31356", "l": "dimethyl sulfide + H(+) + NADH + O2 => formaldehyde + H2O + methanethiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28030", "l": "[thioredoxin]-disulfide + dGDP + H2O = [thioredoxin]-dithiol + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375160", "l": "NCAM1 binds to ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34509", "l": "N,N-diacetyllegionaminate + phosphate => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49084", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.72", "l": "\"(-)-pluviatolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16138", "l": "2'-deoxymugineate + NADP(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051978", "l": "lysophospholipid:sodium symporter activity", "d": ["Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70622", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74945", "l": "a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate => 2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021609", "l": "ESR-associated SRC autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73172", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) => adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50884", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047312", "l": "L-phenylalanine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73575", "l": "(E,E)-piperate + ATP + H(+) = (E,E)-piperoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011543", "l": "DCA binds PDK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080123", "l": "jasmonoyl-L-amino acid ligase activity", "d": ["Catalysis of the reaction: a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H+. In Arabidopsis, isoleucine is the principal amino acid that conjugates with JA to form JA (JA-Ile). Other amino acid can be conjugated with JA such as valine, leucine, and phenylalanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60337", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667456", "l": "AVPR1A,B bind desmopressin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61858", "l": "betaenone C + 3 H2O + 3 NADP(+) => dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65625", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76634", "l": "Ca(2+)(in) + n H(+)(out) <=> Ca(2+)(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34311", "l": "4-nitrocatechol + NADH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376145", "l": "SRGAP binds ROBO1:SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33775", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322434", "l": "XIAP dissociates from ub-TLE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10176", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.397", "l": "\"beta-methylindole-3-pyruvate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17569", "l": "(R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.27", "l": "\"1,2-dehydroreticulinium reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13960", "l": "4 H2O + O2 + 4 sulfur <=> 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62972", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33390", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine <=> aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27972", "l": "alpha-D-glucose + D-maltose => D-maltotriose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670416", "l": "Recruitment of STATs by KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65110", "l": "aculene A + holo-[peptidyl-carrier protein] => aculene C + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534359", "l": "CatSper Channel Mediated Calcium Transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981093", "l": "IL12 bound to IL12R internalises (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36588", "l": "an aldopyranose + NADP(+) => aldono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58667", "l": "(S)-2-hydroxyglutarate + a quinone <=> 2-oxoglutarate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20009", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose = H(+) + linamarin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.63", "l": "\"linamarin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201603", "l": "Caspase-mediated cleavage of PKC theta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202721", "l": "JAM2 binds JAM3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430158", "l": "p-SLP-76 binds VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928624", "l": "EPHBs bind EFNBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0019212", "l": "phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034804", "l": "benzo(a)pyrene 11,12-epoxidase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909729", "l": "Activation of JAK kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917696", "l": "Cargo Sequestration (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38625", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11317", "l": "an aliphatic aldoxime => a nitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69011", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 <=> 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23104", "l": "D-arabinose 5-phosphate = D-ribulose 5-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.13", "l": "\"arabinose-5-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624272", "l": "MMPs cleave HB-EGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55168", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22530", "l": "a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70863", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) = L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984821", "l": "Kinesin-12 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36933", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11093", "l": "NAD(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11488", "l": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.76", "l": "\"retinol O-fatty-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76179", "l": "a dipeptide(out) + 2 H(+)(out) = a dipeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71063", "l": "L-arginine(in) + L-histidine(out) = L-arginine(out) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55135", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63729", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan-2-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851988", "l": "BTN2A2 binds T cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.-", "l": "\"Peptidyl peptide hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2529020", "l": "CK2 phosphorylates condensin I subunits (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470010", "l": "Dimerization of STATs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49544", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.-.-", "l": "\"Transferring molybdenum- or tungsten-containing groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69925", "l": "brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => castasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008684", "l": "TBK1 phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65772", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36274", "l": "caffeine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27684", "l": "ADP + dTTP => ATP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20764", "l": "(S)-methylmalonyl-CoA + pyruvate = oxaloacetate + propanoyl-CoA", "d": [], "t": []}, {"i": "EC:2.1.3.1", "l": "\"methylmalonyl-CoA carboxytransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75856", "l": "Abortive Initiation Before Second Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164834", "l": "Enzyme-bound ATP is released (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.12", "l": "\"nepenthesin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73934", "l": "chloride + FADH2 + griseophenone C + O2 <=> FAD + griseophenone B + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805507", "l": "APAF1 binds AVEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58967", "l": "H2O + hexanal + O2 <=> H(+) + H2O2 + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097258", "l": "20-hydroxy-leukotriene B4 omega oxidase activity", "d": ["Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050694", "l": "galactose 3-O-sulfotransferase activity", "d": ["Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102243", "l": "ATP:geranylgeraniol phosphotransferase activity", "d": ["Catalysis of the reaction: (E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32367", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": [], "t": []}, {"i": "EC:1.3.2.3", "l": "\"L-galactonolactone dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38837", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56047", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617815", "l": "BBSome binds RAB3IP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76807", "l": "(S)-isoleucinol + H2O + NAD(+) = (3S)-1-hydroxy-3-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70764", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15425", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": [], "t": []}, {"i": "EC:1.3.98.3", "l": "\"coproporphyrinogen dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42974", "l": "a cardiolipin + ethanolamine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39875", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31090", "l": "acetyl-CoA + octanoyl-CoA <=> 3-oxodecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709360", "l": "H2O2 reduces MetHb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508513", "l": "PTK2B binds JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754129", "l": "CDK6 inhibitors bind CDK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66193", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O => ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201457", "l": "BMP2 binds to the receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69549", "l": "H(+) + O-phospho-L-serine => CO2 + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008421", "l": "long-chain fatty-acyl-glutamate deacylase activity", "d": ["Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39586", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176175", "l": "Stalling of DNA replication fork and RPA binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.-.-.-", "l": "\"Transferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220613", "l": "EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38224", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol => 1-O-decyl-(9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29608", "l": "H2O + NAD(+) + nitrous oxide => H(+) + NADH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40604", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209828", "l": "Tryptophan is hydroxylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56333", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O => AMP + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382055", "l": "Grb7 binds to the active PDGF receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19054", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O => H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29034", "l": "L-glutamate(in) + 2 Na(+)(in) <=> L-glutamate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380780", "l": "Activation of Src (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17373", "l": "all-trans-antheraxanthin = all-trans-capsanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12704", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69051", "l": "H2O + hexano-6-lactone <=> 6-hydroxyhexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39359", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19927", "l": "D-ribulose 5-phosphate + H(+) + NADH => D-ribitol 5-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30089", "l": "2-oxoglutarate + FADH2 => (S)-2-hydroxyglutarate + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53980", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004818", "l": "glutamate-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41930", "l": "NADP(+) + octadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77546", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA <=> 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66262", "l": "AMP + H(+) + IC-asc-C7-CoA => CoA + IC-asc-C7-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0030291", "l": "protein serine/threonine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10333", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29157", "l": "2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in) => 2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30810", "l": "L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14796", "l": "2-hydroxyadipate + NAD(+) <=> 2-oxoadipate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444516", "l": "Formation of MSH2:MSH6 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43145", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11964", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433542", "l": "Phosphorylation and activation of VAV1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26432", "l": "diphosphate + phyllocladan-16alpha-ol => (+)-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28753", "l": "dihydroxyacetone phosphate + ubiquinol-8 => sn-glycerol 3-phosphate + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983153", "l": "E1 mediated ubiquitin activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60957", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47763", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052638", "l": "indole-3-butyrate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64187", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine <=> (9Z)-octadecenoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14978", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 3-carboxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20680", "l": "alizarin + UDP-alpha-D-glucose <=> 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13702", "l": "acetyl-CoA + L-homoserine => CoA + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375138", "l": "CDO binds BOC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984226", "l": "PLK1 phosphorylates NEK9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12132", "l": "ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5228992", "l": "ROCK1,ROCK2 are activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68965", "l": "2-hydroxyoctadecanoate + O2 => 2-oxooctadecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32717", "l": "2-oxobutanoate + CO2 + NADH => (2R,3S)-3-methylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710295", "l": "IRF2 or IRF1 binds the GSDMD gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77685", "l": "a globoside GalGb3Cer (d18:1(4E)) + H(+) + UDP => a globoside Gb3Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102514", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156678", "l": "Activation of Cdc25C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47444", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA = (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695964", "l": "ABHD14B hydrolyses PNPB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76690", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione <=> (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62889", "l": "GDP-beta-L-fucose + lactose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38745", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20197", "l": "[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)", "d": [], "t": []}, {"i": "EC:5.1.3.17", "l": "\"heparosan-N-sulfate-glucuronate 5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29763", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36619", "l": "2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35031", "l": "L-serine(in) = L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47944", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875558", "l": "RAPGEF1 binds CRK,CRKL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35840", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => a cardiolipin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42923", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA <=> H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24872", "l": "5'-deoxyadenosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41999", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> a globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21798", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-beta-L-rhamnose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044015", "l": "histone H2BK12 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34854", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) <=> 3-oxoadipyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66443", "l": "butan-2-one + NADP(+) <=> but-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9834821", "l": "p-PRKRA dimer binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48667", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52920", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985104", "l": "OAS2 produces oligoadenylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55507", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41968", "l": "a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16670", "l": "H2O + NAD(+) + xanthine => H(+) + NADH + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177926", "l": "Dephosphorylation of PAG by SHP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050288", "l": "sorbose dehydrogenase activity", "d": ["Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467633", "l": "AGRN binds LRP4:MUSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013021", "l": "GDIs block activation of RHOB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192123", "l": "CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46147", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55835", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.8", "l": "\"capsanthin/capsorubin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12730", "l": "lutein => (3R,3'S)-zeaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39143", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102614", "l": "germacrene A acid 8beta-hydroxylase activity", "d": ["Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ = 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972962", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018457", "l": "perillyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + perillyl alcohol = H+ + NADH + perillyl aldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805205", "l": "GPR35 binds kynurenic acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205306", "l": "Interaction of SHP1 and KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9837337", "l": "DCAKD phosphorylates DP-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.283939330411002", "identifiers": [{"i": "GO:0004540", "l": "RNA nuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31427", "l": "(2E,6E)-farnesyl diphosphate = (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.81", "l": "\"exo-alpha-bergamotene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517674", "l": "p-S158,221-HuR binds mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12276", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.4", "l": "\"isovaleryl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75044", "l": "L-cystine(out) + L-leucine(in) => L-cystine(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49237", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose => L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429730", "l": "PPM1L dephosphorylates multiphospho-CERT1-2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20816", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.230", "l": "\"3alpha-hydroxyglycyrrhetinate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-990489", "l": "Kinesin-13 is a dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56458", "l": "12-epi-fischerindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51946", "l": "2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "53.538359132701942", "identifiers": [{"i": "GO:0016772", "l": "transferase activity, transferring phosphorus-containing groups", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.7.-.-", "l": "\"Transferring phosphorus-containing groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77060", "l": "3-methylcyclopentanamine + H2O + NADP(+) => 3-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674529", "l": "AAMP binds to TBXA2R (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31522", "l": "O2 + torulene <=> 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13735", "l": "an alk-2-enal + H(+) + NADH => an n-alkanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11652", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose = alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.6", "l": "\"undecaprenyl-phosphate galactose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61268", "l": "H2O + L-2-aminohexanoate + O2 = 2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938231", "l": "RUNX1:CBFB binds CREBBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373746", "l": "SEMA4D interacts with CD45 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73189", "l": "(2R,3S,11R)-aszonalenin + diphosphate => (R)-benzodiazepinedione + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37113", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34013", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1972385", "l": "ADP-Ribosylation of HNP-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39724", "l": "a 1,2-diacyl-sn-glycerol(in) => a 1,2-diacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24862", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose => H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052919", "l": "aliphatic (R)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide."], "t": []}, {"i": "RHEA:28170", "l": "(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide", "d": [], "t": []}, {"i": "EC:4.1.2.46", "l": "\"aliphatic (R)-hydroxynitrile lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45561", "l": "L-isoleucine => D-allo-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13540", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.39", "l": "\"hydroxyjasmonate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53959", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) <=> 4-aminobutanoyl-[BtrI ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69025", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 => H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60894", "l": "a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32500", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 => (1S,3R,5S)-sabinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43695", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] <=> AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22429", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 => 2 H2O + isopenicillin N", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17399", "l": "a 3-oxoacyl-[ACP] + H(+) + NADPH => a (3R)-hydroxyacyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38640", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13740", "l": "an n-alkanal + NADP(+) <=> an alk-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382056", "l": "Crk binds to the active PDGF receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69683", "l": "daidzein 7-O-beta-D-glucoside + H2O = beta-D-glucose + daidzein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63890", "l": "CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine => hexadecanoyl-CoA + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65724", "l": "2-oxoglutarate + O2 + pentyl sulfate = CO2 + H(+) + pentanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49605", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) => 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71138", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) <=> H(+)(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "78.496617203483822", "identifiers": [{"i": "GO:0140103", "l": "catalytic activity, acting on a glycoprotein", "d": ["Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034926", "l": "pyrene-4,5-epoxide hydrolase activity", "d": ["Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23972", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) = (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": [], "t": []}, {"i": "EC:7.2.4.5", "l": "\"glutaconyl-CoA decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10307", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0045181", "l": "glutamate synthase activity, NAD(P)H as acceptor", "d": ["Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905334", "l": "Swi5-Sfr1 complex binding", "d": ["Binding to a Swi5-Sfr1 complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166817", "l": "Cleavage of C3 by C3 convertases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70873", "l": "L-glutamine(out) + L-valine(in) + Na(+)(in) => L-glutamine(in) + L-valine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674019", "l": "BRAP binds KSR1:MARK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33752", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57424", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] = catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322422", "l": "Beta-catenin recruits SMARCA4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031725", "l": "CXCR6 chemokine receptor binding", "d": ["Binding to a CXCR6 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983153", "l": "E1 mediated ubiquitin activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20627", "l": "2 Fe(II)-[cytochrome c3] + 2 H(+) => 2 Fe(III)-[cytochrome c3] + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37464", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21458", "l": "(S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857336", "l": "CEBPB homodimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48666", "l": "12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16381", "l": "L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.12", "l": "\"L-arabinitol 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63697", "l": "SN-38 + UDP-alpha-D-glucuronate => H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14054", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223200", "l": "Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379977", "l": "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72051", "l": "butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46806", "l": "a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48606", "l": "2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16373", "l": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.33", "l": "\"pantothenate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38003", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.116", "l": "\"homogentisate geranylgeranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2429719", "l": "MCPH1 sequesters condensin II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21713", "l": "L-threo-3-phenylserine => benzaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13269", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.45", "l": "\"glucosylceramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36965", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102808", "l": "pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside = H+ + pelargonidin 3-O-sophoroside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018777", "l": "1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity", "d": ["Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.584647820776595", "identifiers": [{"i": "GO:0043168", "l": "anion binding", "d": ["Binding to an anion, a charged atom or group of atoms with a net negative charge."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350901", "l": "Iodide is organified (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10724", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50315", "l": "2-oxopentanoate + H(+) <=> butanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030429", "l": "kynureninase activity", "d": ["Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57189", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glycolate + H(+) + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75140", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 => asukamycin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63047", "l": "H2O + mevastatin <=> H(+) + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68728", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102502", "l": "ADP-glucose-starch glucosyltransferase activity", "d": ["Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801762", "l": "REG3A oligomerize to form a pore complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25585", "l": "alpha-L-rhamnose => beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49065", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003992", "l": "N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102585", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ = cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19174", "l": "H(+) + NADH + naphthalene + O2 => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76197", "l": "UDP-alpha-D-glucose(out) => UDP-alpha-D-glucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53732", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate = 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379387", "l": "COMT transfers Met to DA to form 3MT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76596", "l": "a dicarboxylate(in) + sulfate(out) => a dicarboxylate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029471", "l": "Hydrolysis of PC to PA by PLD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69519", "l": "N-acetyl-D-galactosamine + O2 <=> H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52636", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18943", "l": "a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH => a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785594", "l": "FANCD2 binds FANCI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21733", "l": "chorismate + L-glutamine => anthranilate + H(+) + L-glutamate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17358", "l": "O2 + 2 R'C(R)SH => H2O2 + R'C(R)S-S(R)CR'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809707", "l": "MTMR12 binds MTMR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635102", "l": "GPR161 is internalized (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9633044", "l": "ESR binds STRN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65514", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2 => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16173", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.78", "l": "\"(S)-norcoclaurine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39741", "l": "3,12-dihydroxydodecanoate + H2O + NADP(+) => 3-hydroxydodecanoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35960", "l": "H(+) + NADPH + O2 + tryprostatin B => demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33384", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine => (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856398", "l": "NPTN binds GABA A receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23633", "l": "D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3095889", "l": "MMACHC dealkylates RCbl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22205", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140416", "l": "transcription regulator inhibitor activity", "d": ["A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0045309", "l": "protein phosphorylated amino acid binding", "d": ["Binding to a phosphorylated amino acid residue within a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168299", "l": "Ribonucleoprotein release from M1 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14360", "l": "ATP + riboflavin <=> ADP + FMN + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35965", "l": "fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63693", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate => a beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0016500", "l": "protein-hormone receptor activity", "d": ["Combining with a protein hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24802", "l": "2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16884", "l": "hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31022", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 <=> 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30309", "l": "formaldehyde + H2O + NADP(+) + xanthine => 7-methylxanthine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15541", "l": "DIMBOA + UDP-alpha-D-glucose = DIMBOA beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050815", "l": "phosphoserine residue binding", "d": ["Binding to a phosphorylated serine residue within a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11232", "l": "3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.6.2.2", "l": "\"phosphoadenylylsulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112379", "l": "Recruitment of elongation factors to form elongation complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71449", "l": "D-alanine(out) + Na(+)(out) => D-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58244", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] = ADP-D-ribose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140108", "l": "high-affinity glucose transmembrane transporter activity", "d": ["Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66370", "l": "4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA => 6-methyl-3,7-dioxodecanedioyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031803", "l": "Maresin-like SPMs translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.83", "l": "\"anthrax lethal factor endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-688137", "l": "RIP2 is K63 polyubiquitinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836702", "l": "PKR inhibitors bind PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39401", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174235", "l": "Association of Emi1 with Cdc20 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17985", "l": "4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.47", "l": "\"4-trimethylammoniobutyraldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41016", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204303", "l": "MRE11 binds cytosolic DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46292", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74594", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351207", "l": "Spermine  => N-acetylated spermine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26246", "l": "geranylgeranyl diphosphate => diphosphate + fusicocca-2,10(14)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1671687", "l": "PRLR activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61467", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58240", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] = ADP-D-ribose + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-881988", "l": "CRY is phosphorylated by SGG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60350", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870269", "l": "Gastrin binds to CCK-B receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76274", "l": "N,N-dimethylglycine(in) <=> N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.42", "l": "\"[glycogen-synthase-D] phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944362", "l": "TCF/LEF:CTNNB1 bind canonical WNT target promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13509", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.7.7.23", "l": "\"UDP-N-acetylglucosamine diphosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13435", "l": "2'-deoxyuridine + NH4(+) => 2'-deoxycytidine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25836", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.22", "l": "\"3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726509", "l": "NR3C2 binds fludrocortisone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46467", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102499", "l": "SHG alpha-glucan phosphorylase activity", "d": ["Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36476", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56715", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] <=> H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392263", "l": "AVP(20-28) binds AVPR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70734", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160102", "l": "tRNA (guanine(10)-N2)-methyltransferase activity", "d": ["Catalysis of the reaction: guanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70241", "l": "PCK1 phosphorylates OA to yield PEP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809764", "l": "SBF1 binds MTMR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59852", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66994", "l": "3-methylpentanoyl-CoA + AMP + diphosphate => 3-methylpentanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64034", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798748", "l": "Exocytosis of secretory granule lumen proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60666", "l": "NADH + phosphate => H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64357", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052694", "l": "jasmonoyl-isoleucine-12-hydroxylase activity", "d": ["Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65434", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+) => a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36723", "l": "2-phenylethylamine + A + H2O = 2-phenylacetaldehyde + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61638", "l": "AMP + diphosphate + isophthalyl-CoA => ATP + CoA + isophthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41009", "l": "6-linalyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68344", "l": "ATP + GTP = 3',2'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61524", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56794", "l": "2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052726", "l": "inositol-1,3,4-trisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702849", "l": "CALCR binds gepants (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57865", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40847", "l": "eicosanoyl-CoA + FAD + H(+) = (2E)-eicosenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102422", "l": "curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose = curcumin 4'-O-beta-D-gentiotetraside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750666", "l": "ALB binds ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451033", "l": "(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43454", "l": "4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexanoyl-CoA + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102425", "l": "myricetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: myricetin + UDP-alpha-D-glucose = myricetin 3-O-beta-D-glucopyranoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264865", "l": "Caspase-mediated cleavage of Lamin A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852324", "l": "GTSE1 binds PLK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37159", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.95", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641229", "l": "TLE oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662606", "l": "MT3 binds zinc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32944", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11556", "l": "(S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.254", "l": "\"(S)-carnitine 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.142", "l": "\"limit dextrinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66198", "l": "CoA + H(+) + N-acetyltryptamine => acetyl-CoA + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685179", "l": "SARS-CoV-1 N protein binds TRIM25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212222", "l": "PRC2 recruits DNA methyltransferases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12996", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879762", "l": "Expression of DBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67562", "l": "adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390663", "l": "ADRA2A,B,C bind ADR,NAd (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72935", "l": "(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65981", "l": "hnu + previtamin D3 => tachysterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102972", "l": "gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming)", "d": ["Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666001", "l": "Profilin:G-actin binds MKL1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47434", "l": "(2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44473", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61727", "l": "a D-glucoside + NAD(+) <=> a 3-dehydro-D-glucoside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15393", "l": "(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate", "d": [], "t": []}, {"i": "EC:5.1.1.7", "l": "\"diaminopimelate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418200", "l": "SRC-1 bound to ARRB2 is not activated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13990", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41936", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416690", "l": "SEMA4A binds to PLXND1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71612", "l": "(S)-malate(in) + malonate(out) => (S)-malate(out) + malonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13370", "l": "dimethylallyl diphosphate => diphosphate + isoprene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58992", "l": "(E)-cinnamaldehyde + H2O + O2 = (E)-cinnamate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77347", "l": "L-alanine + oxaloacetate = L-aspartate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793564", "l": "Cipro HCl dissolves (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64849", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA => (3Z)-hex-3-en-1-yl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167415", "l": "G-protein alpha subunit is inactivated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18594", "l": "sphinganine 1-phosphate => hexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13477", "l": "H2O + L-tryptophan + NADP(+) = H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102094", "l": "S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol = S-adenosyl-L-homocysteine + H+ + a menaquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19325", "l": "H(+) + NADH + O2 + quinolin-4-ol = H2O + NAD(+) + quinoline-3,4-diol", "d": [], "t": []}, {"i": "EC:1.14.13.62", "l": "\"4-hydroxyquinoline 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.9", "l": "\"isotuberculosinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592245", "l": "NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45835", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638845", "l": "CERK phosphorylates CERA to form C1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114671", "l": "vWF binds to collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10123", "l": "adenosine in double-stranded RNA + H(+) + H2O <=> inosine in double-stranded RNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626914", "l": "α2-agonists bind ADRA2A,B,C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62709", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose => 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69179", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] <=> 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5225649", "l": "RBBP7 binds histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654625", "l": "Activated FGFR3 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56983", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29525", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034018", "l": "ascopyrone tautomerase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856945", "l": "PP2A methylation by LCMT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675656", "l": "EDA:EDAR binds EDARADD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47168", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34893", "l": "selenite(out) => selenite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390930", "l": "5-HT2 receptor can bind serotonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32138", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63746", "l": "UDP + zolarsartan-1-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31333", "l": "adenylyl-molybdopterin + diphosphate => ATP + H(+) + molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29114", "l": "H(+) + NADPH + ubiquinone-8 <=> NADP(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803858", "l": "TP53 binds the SFN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42295", "l": "a fatty acyl-[ACP] + phosphate <=> an acyl phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795667", "l": "MDM2 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69124", "l": "glyoxylate + L-tryptophan = glycine + indole-3-pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794345", "l": "NLGNs binds PSD-95 subfamily members (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19637", "l": "D-nopaline + H2O + NADP(+) = 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.19", "l": "\"D-nopaline dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42914", "l": "5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12641", "l": "(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.95", "l": "\"phosphoglycerate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46705", "l": "ATP + H(+) + salicylate => 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803890", "l": "SFN dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33360", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099615", "l": "(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44330", "l": "glycerol + H(+) + octanoate => 1-octanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26224", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102658", "l": "2-oxo-5-methylthiopentanoate aminotransferase activity", "d": ["Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid = L-homomethionine + a 2-oxo carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29262", "l": "(2R,3R)-tartrate(out) + succinate(in) <=> (2R,3R)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134914", "l": "Beta-catenin migrates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102922", "l": "phenylpropanoyltransferase activity", "d": ["Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41003", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201637", "l": "Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682011", "l": "LC3 binds ATG7 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60435", "l": "A + cannabigerolate <=> AH2 + cannabichromenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11305", "l": "(S)-ureidoglycolate => glyoxylate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14563", "l": "CoA + H(+) + piperine => (E,E)-piperoyl-CoA + piperidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034075", "l": "arabidiol synthase activity", "d": ["Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61058", "l": "H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44324", "l": "1-butyrylglycerol + H2O = butanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40456", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55713", "l": "3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043810", "l": "ornithine-acyl [acyl carrier protein] N-acyltransferase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54168", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.49", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050615", "l": "1,2-dihydrovomilenine reductase activity", "d": ["Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48733", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O => [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047813", "l": "D-arabinitol 4-dehydrogenase activity", "d": ["Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72407", "l": "H(+)(in) + Li(+)(out) = H(+)(out) + Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40891", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850794", "l": "SPINK6 binds KLK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928646", "l": "EPHAs bind EFNAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68913", "l": "ATP + H(+) + NADPH + propanoate => AMP + diphosphate + NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68957", "l": "S-adenosyl-L-methionine + scopoletin => H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008737", "l": "L-fuculokinase activity", "d": ["Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32165", "l": "AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine => ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31618", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine <=> dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22855", "l": "L-serine + pyruvate <=> 3-hydroxypyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72651", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 = 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31407", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) = all-trans-4,4'-diapolycopene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77077", "l": "Capping complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35849", "l": "ADP + H(+) + sphing-4-enine 1-phosphate => ATP + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48856", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76308", "l": "L-aspartate(in) + L-glutamate(out) => L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51679", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34674", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102810", "l": "glutarate-semialdehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32994", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24752", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite = 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.12", "l": "\"red chlorophyll catabolite reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351876", "l": "Caspase-mediated cleavage of occludin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818682", "l": "MEN1 binds MLL2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42164", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50576", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34583", "l": "2-oxoglutarate + O2 + pentalenolactone D = CO2 + H2O + pentalenolactone E + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14998", "l": "deoxylimonoate + H2O => deoxylimononate D-ring-lactone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44389", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72603", "l": "(E)-sinapate + ATP + H(+) = (E)-sinapoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45887", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019959", "l": "interleukin-8 binding", "d": ["Binding to interleukin-8."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15808", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 <=> (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605259", "l": "Active FLT3 binds FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44170", "l": "dodecanal + H2O + NAD(+) => dodecanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54001", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112392", "l": "Resumption of elongation after recovery from pausing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008773", "l": "[protein-PII] uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814088", "l": "SYS1 binds AcM-ARFRP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68246", "l": "L-phenylalanine(out) + Na(+)(out) => L-phenylalanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54561", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74864", "l": "(R)-salsolinol + S-adenosyl-L-methionine => H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28424", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33165", "l": "beta-nicotinamide D-riboside(out) => beta-nicotinamide D-riboside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44116", "l": "eicosan-1-ol + hexadecanoyl-CoA = CoA + eicosanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19182", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050094", "l": "methionine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190829", "l": "Lysosomal degradation of gap junction plaques (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59828", "l": "H2O + S-inosyl-L-homocysteine = inosine + L-homocysteine", "d": [], "t": []}, {"i": "EC:3.13.1.9", "l": "\"S-inosyl-L-homocysteine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19657", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47903", "l": "a ganglioside GM3 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879782", "l": "Expression of AVP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015519", "l": "D-xylose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695949", "l": "SPHK2 phosphorylates sphingoid (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69337", "l": "(E)-alk-1-en-1-SO-peroxol => (Z)-alkanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56545", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28548", "l": "alpha-D-fructose => alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53803", "l": "lithocholoyl-CoA + ursodeoxycholate <=> lithocholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901006", "l": "Binding of Malectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41199", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41431", "l": "L-tyrosine + S-adenosyl-L-methionine <=> 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57622", "l": "H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18121", "l": "an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.4.1.13", "l": "\"cysteine-S-conjugate beta-lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031697", "l": "beta-1 adrenergic receptor binding", "d": ["Binding to a beta-1 adrenergic receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58689", "l": "NADH + O2 + rifamycin SV => H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.24", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37223", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25136", "l": "phosphate + pyridoxamine => H2O + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42741", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835358", "l": "p-TARBP2 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.198", "l": "\"alpha-selinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25788", "l": "4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:4.1.2.52", "l": "\"4-hydroxy-2-oxoheptanedioate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65503", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299338", "l": "Activation of TRESK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008866", "l": "fructuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875558", "l": "RAPGEF1 binds CRK,CRKL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49456", "l": "(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": [], "t": []}, {"i": "EC:3.3.2.15", "l": "\"trans-2,3-dihydro-3-hydroxyanthranilic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36674", "l": "(17Z)-hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168947", "l": "Ligand binds to TLR10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323526", "l": "FRAT proteins bind GSK3beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42995", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (R)-nephthenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69565", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine => 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43089", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine => 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102771", "l": "sphingolipid very long chain fatty acid alpha-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14809", "l": "phenol + S-adenosyl-L-methionine = anisole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.25", "l": "\"phenol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0043752", "l": "adenosylcobinamide kinase activity", "d": ["Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39337", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804402", "l": "TP53 binds POU4F1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61888", "l": "diosgenin + UDP-alpha-D-glucose = diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990464", "l": "D-2-hydroxyacid dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19978", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester => adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29125", "l": "H2O(out) + nitrite(out) + ubiquinone-8(in) => nitrate(out) + ubiquinol-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76875", "l": "H2O + hexan-2-amine + NAD(+) = H(+) + hexan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59981", "l": "8-oxo-dGTP + H2O => 8-oxo-dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10534", "l": "D-glyceraldehyde 3-phosphate + H2O + L-tryptophan => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56703", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18436", "l": "cyclohexylamine + H2O + O2 <=> cyclohexanone + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340124", "l": "CSN polymer binds CaPO4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.-", "l": "\"Transferring other glycosyl groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.211", "l": "\"rifampicin monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71438", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) <=> an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57202", "l": "N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glyoxal + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53107", "l": "4-hydroxyestrone + S-adenosyl-L-methionine <=> 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26129", "l": "(+)-copalyl diphosphate => diphosphate + isopimara-7,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008809", "l": "carnitine racemase activity", "d": ["Catalysis of the reaction: D-carnitine = L-carnitine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68266", "l": "(6S)-5,6,7,8-tetrahydrofolate + formaldehyde => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67404", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57555", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631941", "l": "SESN1,2,3 bind AMPK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75131", "l": "neomorphinone = morphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40116", "l": "H2O + hexanoyl-CoA => CoA + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50697", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806732", "l": "GNLY binds the bacterial cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004778", "l": "succinyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + succinyl-CoA = CoA + H+ + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034002", "l": "(R)-limonene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40205", "l": "14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694406", "l": "nsp13 binds DDX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428260", "l": "DEGS2 oxygenates dihydroceramide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58805", "l": "5'-pApG-3' + H2O => 5'-ApG-3' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39079", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) = 3-oxododecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64565", "l": "8-epi-ilicicolin H => ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32215", "l": "(6R)-NADHX = (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103117", "l": "UDP-3-O-acyl-N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45199", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] <=> 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25798", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23965", "l": "(E)-coniferaldehyde + H2O + NADP(+) => (E)-ferulate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70652", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58575", "l": "O-acetyl-15alpha-stemmadenine + O2 <=> H2O2 + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44931", "l": "2-oxoheptanedioate + acetyl-CoA + H2O <=> (R)-trihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52859", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17942", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13996", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate <=> 2-methyl-3-oxopropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51842", "l": "2 Na(+)(in) + tauroallocholate(in) => 2 Na(+)(out) + tauroallocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140831", "l": "L-asparagine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-asparagine(out) + Na+(out) = H+(out) + L-asparagine(in) + Na+(in)."], "t": []}, {"i": "RHEA:71131", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) = H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866857", "l": "CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051778", "l": "ent-7-alpha-hydroxykaurenoate oxidase activity", "d": ["Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69022", "l": "H2O + N-hydroxy-L-aspartate + NADP(+) => L-aspartate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43912", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59509", "l": "fumarate + L-cysteinyl-[protein] => S-(2-succinyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36163", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.21", "l": "\"nicotinate phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52116", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55688", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49426", "l": "ADP + H(+) + validone 7-phosphate => ATP + validone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28779", "l": "4-hydroxy-L-threonine = glycine + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61216", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50882", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62587", "l": "ATP + H2O + L-tyrosine(out) <=> ADP + H(+) + L-tyrosine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645428", "l": "ALPK1 binds ADP-heptose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047822", "l": "hypotaurine dehydrogenase activity", "d": ["Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980138", "l": "NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35688", "l": "NADP(+) + tetradecasphinganine => 3-oxotetradecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.80", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31821", "l": "5-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31617", "l": "dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51934", "l": "2 Fe(II)-[cytochrome c3] + thiosulfate => 2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795473", "l": "PDPK1 phosphorylates SGK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57441", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] => 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61337", "l": "ATP + H2O + protoporphyrin IX(in) => ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114683", "l": "Phosphorylation of Platelet Sec-1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "60.02532655727714", "identifiers": [{"i": "GO:0098772", "l": "molecular function regulator activity", "d": ["A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28301", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36342", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16112", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53112", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051537", "l": "2 iron, 2 sulfur cluster binding", "d": ["Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10043", "l": "adenosine 3',5'-bisphosphate + H2O <=> AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050474", "l": "(S)-norcoclaurine synthase activity", "d": ["Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36145", "l": "hexadecanoyl-CoA + NADP(+) => (2E)-hexadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016496", "l": "substance P receptor activity", "d": ["Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37809", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71958", "l": "glutarate(out) + 3 Na(+)(out) <=> glutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16979", "l": "2-oxopropyl-coenzyme M + CO2 + NADPH => acetoacetate + coenzyme M + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160124", "l": "guanyl nucleotide exchange factor activator activity", "d": ["Binds to and increases the activity of a guanyl nucleotide exchange factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202127", "l": "eNOS synthesizes NO (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102365", "l": "taxusin 2-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201316", "l": "Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389756", "l": "AKT interacts and phosphorylates Cot (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016493", "l": "C-C chemokine receptor activity", "d": ["Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982066", "l": "Ligand-independent phosphorylation of overexpressed FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40344", "l": "3-oxohexadecanedioyl-CoA + CoA => acetyl-CoA + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46623", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047727", "l": "isobutyryl-CoA mutase activity", "d": ["Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070905", "l": "serine binding", "d": ["Binding to 2-amino-3-hydroxypropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426489", "l": "RISC binds inexactly matching target RNAs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761452", "l": "CTNNA1 binds to CDH11-bound CTNNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034550", "l": "dimethylarsinate reductase activity", "d": ["Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391936", "l": "EP1 receptor can bind PGE2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47194", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.41", "l": "\"sterol 22-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49099", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11844", "l": "acetyl-CoA + formate = CoA + pyruvate", "d": [], "t": []}, {"i": "EC:2.3.1.54", "l": "\"formate C-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71349", "l": "chloride(in) + L-lysine(in) + 2 Na(+)(in) => chloride(out) + L-lysine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10669", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655295", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70223", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74983", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] = (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0046983", "l": "protein dimerization activity", "d": ["The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64689", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62449", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP => AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64773", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48661", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031856", "l": "Sulfido conjugates translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23790", "l": "acetyl-[citrate lyase ACP] + AMP + diphosphate => acetate + ATP + holo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102943", "l": "trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity", "d": ["Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632738", "l": "DDIT4 binds 14-3-3 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785213", "l": "LIPC dimer binds heparin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34027", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56795", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52240", "l": "2 H2O + 2 Mn(2+) + O2 = 4 H(+) + 2 MnO2", "d": [], "t": []}, {"i": "EC:1.16.3.3", "l": "\"manganese oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74813", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482770", "l": "Release of platelet secretory granule components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65307", "l": "2-oxoglutarate + O2 + verruculide A <=> chrodrimanin T + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37955", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52947", "l": "cholate + UDP-alpha-D-glucuronate <=> choloyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62155", "l": "dGMP + dTTP <=> dGDP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112396", "l": "Separation of elongating transcript from template (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805479", "l": "TP53RK phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62316", "l": "salicylate + UDP-alpha-D-glucose = 1-O-salicyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63040", "l": "H2O + lovastatin = H(+) + lovastatin carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830867", "l": "G is O-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48693", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050330", "l": "theanine hydrolase activity", "d": ["Catalysis of the reaction: N(5)-ethyl-L-glutamine + H2O = L-glutamate + ethylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70997", "l": "L-cystine(in) + L-glutamate(out) => L-cystine(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875661", "l": "GGA3 associates with activated MET receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877153", "l": "STARD7 binds PC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938930", "l": "RUNX1 binds ELF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66625", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69063", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709179", "l": "DPP4 binds DPP4 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033922", "l": "peptidoglycan beta-N-acetylmuramidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353056", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42340", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44977", "l": "(R)-carnitine + propanoyl-CoA => CoA + O-propanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20326", "l": "N-hydroxy-4-acetylaminobiphenyl => N-acetoxy-4-aminobiphenyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53400", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10008", "l": "[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047196", "l": "long-chain-alcohol O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53406", "l": "13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56469", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45112", "l": "gamma-tocopherol + H(+) + NADPH + O2 = 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982792", "l": "Growth hormone receptor binds JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66561", "l": "(R)-noradrenaline + L-glutaminyl-[protein] => 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16027", "l": "an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57206", "l": "N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glyoxal + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156699", "l": "Inactivation of Wee1 kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42422", "l": "(4R)-4-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47827", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] <=> 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73863", "l": "dopamine(out) = dopamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251555", "l": "Expression of AXIN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33739", "l": "2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670888", "l": "F9 variant is not secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62154", "l": "dGDP + dTDP => dGMP + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54403", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1980125", "l": "ITCH binds DTX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22046", "l": "ADP + 2 H(+)(out) + K(+)(in) + phosphate => ATP + H(+)(in) + H2O + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17892", "l": "H2O + phosphoethanolamine <=> acetaldehyde + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28258", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.254", "l": "\"cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49150", "l": "dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182859", "l": "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198756", "l": "ERK1/2 phosphorylates MSK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351876", "l": "Caspase-mediated cleavage of occludin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74715", "l": "Autophosphorylation of insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.1", "l": "\"sesamin methylene transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19376", "l": "H2O + L-saccharopine + NADP(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21856", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": [], "t": []}, {"i": "EC:4.2.1.100", "l": "\"cyclohexa-1,5-dienecarbonyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218806", "l": "FYN autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196857", "l": "PANK2 phosphorylates PanK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68950", "l": "H(+) + S-adenosyl-L-homocysteine + scopoletin => esculetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696670", "l": "CHD1L is recruited to GG-NER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420202", "l": "Secretin receptor binds secretin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24791", "l": "(2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375140", "l": "CDO binds promyogenic cadherins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71733", "l": "citrate(in) + tartrate(out) => citrate(out) + tartrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54211", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13940", "l": "4-sulfobenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21765", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388831", "l": "Phosphorylation of CD28 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15108", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65293", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate => 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57757", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25708", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-dihomomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020249", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48013", "l": "4-methyl-5-nitrocatechol + NADPH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55923", "l": "[cis-1,4-isoprene](n) + O2 <=> (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29691", "l": "alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24337", "l": "a carboxylate + ATP + CoA => AMP + an acyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35561", "l": "menaquinol-7 + NAD(+) => H(+) + menaquinone-7 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63440", "l": "(2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.106", "l": "\"3-phospho-D-glycerate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034799", "l": "dihydride TNP tautomerase activity", "d": ["Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27849", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030341", "l": "chondroitin AC lyase activity", "d": ["Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32940", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047403", "l": "lacto-N-biosidase activity", "d": ["Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174124", "l": "Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196929", "l": "FLAD1 phosphorylates FMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.1", "l": "\"heterotrimeric G-protein GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33741", "l": "H2O + hexadecanal + NAD(+) => 2 H(+) + hexadecanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0016653", "l": "oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein."], "t": []}, {"i": "EC:1.6.2.-", "l": "\"With a heme protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19998", "l": "H2O + phosphoenolpyruvate => phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22261", "l": "H2O + triacetate lactone => H(+) + triacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74442", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817575", "l": "ERO1B oxidizes P4HB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57493", "l": "H2O + oxaloacetate + propanoyl-CoA => 2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54826", "l": "alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549322", "l": "OCT1 transports organic cations out of hepatic cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863494", "l": "ASICs bind STOML3, (STOM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60366", "l": "H(+)(in) + myo-inositol(in) => H(+)(out) + myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72721", "l": "AMP + 2 H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-dihydrolipoyl]-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620103", "l": "ALDH2 transforms GTN to NO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72130", "l": "agmatine(in) + H(+)(out) <=> agmatine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.367", "l": "\"UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56004", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}, {"i": "EC:3.2.1.209", "l": "\"endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211583", "l": "Partial autophosphorylation of PAK-2 at  Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40218", "l": "FADH2 + O2 <=> FAD + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.7", "l": "\"interstitial collagenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56439", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28044", "l": "acetyl-CoA + CO2 + NADH => CoA + NAD(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76549", "l": "CoA + H(+) + N-acetyl-D-glutamine => acetyl-CoA + D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389862", "l": "Conversion of glyoxylate to oxalate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49474", "l": "H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP => trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433415", "l": "Activation of RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25740", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209133", "l": "Formation of the 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54093", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.81", "l": "\"(+)-pulegone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451311", "l": "Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610442", "l": "Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372542", "l": "Loading of dopamine into synaptic veiscles (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197698", "l": "Src phosphorylate WASP,N-WASP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21390", "l": "L-lysine => H2O + L-2-aminohexano-6-lactam", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62596", "l": "(S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54129", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17601", "l": "ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2395517", "l": "NADPH transfers electrons to FDXR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21572", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = CO + H(+) + N-acetylanthranilate", "d": [], "t": []}, {"i": "EC:1.13.11.48", "l": "\"3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604752", "l": "Initial activation of proMMP13 by MMP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17950", "l": "3-hydroxy-1H-quinolin-4-one + O2 => CO + H(+) + N-formylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33259", "l": "4-aminoimidazole + H(+) + 2 H2O = N-formimidoylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42541", "l": "uridine(13) in tRNA => pseudouridine(13) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64930", "l": "dAMP + H(+) + phosphate => dADP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24309", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40728", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid => a 1-acylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41046", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71707", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) = H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17397", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.100", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22002", "l": "D-xylono-1,5-lactone + H(+) + NADPH => D-xylose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442387", "l": "ZIP8 mediates zinc influx into cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52110", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12416", "l": "beta-alanyl-CoA = acryloyl-CoA + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.6", "l": "\"beta-alanyl-CoA ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75760", "l": "(9Z,11E)-octadecadienoate + H2O => 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45727", "l": "(E)-4-coumaroyl alcohol + NADP(+) <=> (E)-4-coumaraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15385", "l": "L-asparagine = 3-cyano-L-alanine + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.65", "l": "\"3-cyanoalanine hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591086", "l": "SERPINA5 binds activated protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030774", "l": "anthranilate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34422", "l": "(+)-lariciresinol + NADP(+) <=> (+)-pinoresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050595", "l": "7-deoxyloganin 7-hydroxylase activity", "d": ["Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21758", "l": "dopamine + secologanin => deacetylisoipecoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867041", "l": "EGFR phosphorylates EPS15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60864", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23296", "l": "aceneuramate = N-acetyl-D-mannosamine + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.3", "l": "\"N-acetylneuraminate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786650", "l": "DDHD1,2 hydrolyse PA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47456", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) = 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001860", "l": "complement component C3d receptor activity", "d": ["Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32957", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102900", "l": "dehydroabietadienal hydroxylase activity", "d": ["Catalysis of the reaction: dehydroabietadienal + NADPH + O2 = dehydroabietic acid + NADP + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804527", "l": "INTL1 binds bacterial glycans (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051062", "l": "UDP reductase activity", "d": ["Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41735", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate <=> [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58332", "l": "(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41315", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25958", "l": "3-dehydroquinate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015039", "l": "NADPH-adrenodoxin reductase activity", "d": ["Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983156", "l": "Polyubiquitination of substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40864", "l": "FAD + H(+) + heptadecanoyl-CoA => FADH2 + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31886", "l": "(S)-2,3-epoxysqualene <=> delta-amyrin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72639", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44540", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55638", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate => ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50866", "l": "9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68958", "l": "H(+) + S-adenosyl-L-homocysteine + scoparone => S-adenosyl-L-methionine + scopoletin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23929", "l": "H2O + N(8)-acetylspermidine => acetate + spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23102", "l": "ADP + dADP => ATP + dAMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210824", "l": "HNF6-dependent synthesis of HNF1B protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706837", "l": "AR binds AR antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676133", "l": "CD74 binds MIF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26431", "l": "(+)-copalyl diphosphate + H2O => diphosphate + phyllocladan-16alpha-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60445", "l": "an S-substituted L-cysteinylglycine + H2O => an S-substituted L-cysteine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38313", "l": "daunorubicin + H(+) + S-adenosyl-L-homocysteine => carminomycin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31212", "l": "ATP + H2O + L-selenomethionine => diphosphate + L-adenosylselenomethionine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30567", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate = 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.33", "l": "\"tetrahydrosarcinapterin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64326", "l": "cholesteryl (11Z)-octadecenoate + CoA => (11Z)-octadecenoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047703", "l": "beta-nitroacrylate reductase activity", "d": ["Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33619", "l": "ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77158", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58221", "l": "L-lysyl-[protein] + NAD(+) => H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38303", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.29", "l": "\"D-glucosaminate-6-phosphate ammonia lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28188", "l": "H2O2 + methylglyoxal + NH4(+) => aminoacetone + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19923", "l": "D-ribulose 5-phosphate + H(+) + NADPH => D-ribitol 5-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20950", "l": "CO2 + sulfoacetaldehyde => 3-sulfopyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199154", "l": "CD200 binds to CD200R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62030", "l": "D-glucose + stigmasterol => H2O + stigmasteryl 3-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956639", "l": "RUNX1 binds YAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635845", "l": "GLI proteins bind CDC73 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186780", "l": "PI3-kinase binds to the active receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018839", "l": "cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity", "d": ["Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75644", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532603", "l": "Nephrin mediated activation of N-WASP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691154", "l": "HFE binds TFRC dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51509", "l": "2-oxoglutarate + L-proline + O2 => CO2 + succinate + trans-4-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69542", "l": "6-O-guanylylstreptomycin + diphosphate => GTP + streptomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005118", "l": "sevenless binding", "d": ["Binding to a sevenless (sev) protein, a receptor tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46366", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50368", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 = 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.19.48", "l": "\"tert-amyl alcohol desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5603467", "l": "Activated protein C is released from PROCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68155", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40015", "l": "(+)-copalyl diphosphate + H2O = 13-epi-manool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55170", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63949", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate => phosphate + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44689", "l": "a 2-acylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59784", "l": "H2O + NADP(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76172", "l": "glycyl-L-lysine(out) + 2 H(+)(out) => glycyl-L-lysine(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807106", "l": "PTEN undergoes monoubiquitination (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77673", "l": "a globoside MSGG (d18:1(4E)) + CMP + H(+) => a globoside GalGb4Cer (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429449", "l": "Syk activation leads to SLP-76 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211712", "l": "Proteolytic PAK-2p34 fragment translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54815", "l": "(+)-7-isojasmonate + ATP + L-isoleucine <=> AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31646", "l": "mycinamicin VI + S-adenosyl-L-methionine <=> H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49319", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54083", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16586", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203712", "l": "eNOS associates with Caveolin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803437", "l": "TP53 stimulates ZNF385A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28095", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O => di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40094", "l": "26-hydroxyhexacosanoate + NAD(+) <=> 26-oxohexacosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047103", "l": "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57366", "l": "(6S)-NADHX => H2O + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39987", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61573", "l": "(11Z,14Z)-eicosadienoate + O2 => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139917", "l": "tBID activates BAX protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693536", "l": "ATM phosphorylates MDC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004766", "l": "spermidine synthase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062146", "l": "4-chloro-allylglycine synthase activity", "d": ["Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)."], "t": []}, {"i": "RHEA:59888", "l": "4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691621", "l": "C5 binds C5 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665232", "l": "Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38521", "l": "(9Z)-octadecenoate + 2-octadecanoylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.24", "l": "\"phenylalanine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57447", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65952", "l": "2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035472", "l": "choriogonadotropin hormone receptor activity", "d": ["Combining with the choriogonadotropin hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.184", "l": "\"carbonyl reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061667", "l": "URM1 ligase activity", "d": ["Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S = X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.62", "l": "\"caspase-9\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57729", "l": "H(+) + trans-aconitate => CO2 + itaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33822", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate <=> 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862300", "l": "LYZ binds bacterial peptidoglycan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45978", "l": "9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45931", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35696", "l": "(3S)-versiconol acetate + NADP(+) => (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76837", "l": "acetaldehyde + H(+) + NADH + NH4(+) => ethylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71191", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36235", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.16", "l": "\"cathepsin H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.232", "l": "\"initiation-specific alpha-1,6-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.27", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38122", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64813", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine => CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034988", "l": "Fc-gamma receptor I complex binding", "d": ["Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11998", "l": "biphenyl-2,3-diol + H2O + NAD(+) => biphenyl-2-ol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62692", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 = 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40906", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60061", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865098", "l": "UBA6 conjugates ubiquitin to UBA6 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31864", "l": "(S)-2,3-epoxysqualene => friedelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938930", "l": "RUNX1 binds ELF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31805", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP => H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58399", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21970", "l": "3-dehydroquinate + phosphate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70012", "l": "2-aminobenzoyl-AMP + CoA => AMP + anthraniloyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62902", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.20", "l": "\"DNA-3-methyladenine glycosylase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110011", "l": "Binding of Grb10 to the insulin receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24829", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.21", "l": "\"phosphoribosylglycinamide formyltransferase 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676595", "l": "TRAFs bind RANK:RANKL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9763137", "l": "BRCA2 binds SEM1 (DSS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625421", "l": "The anterograde IFT train dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72905", "l": "butyrolactone I + diphosphate => butyrolactone II + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809680", "l": "MTMR12 binds MTM1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23519", "l": "(R)-glycerate + ATP <=> (2R)-3-phosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41868", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984606", "l": "Kinesin-5 is a homotetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18179", "l": "a (2E)-enoyl-CoA + H(+) + NADH => a 2,3-saturated acyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75080", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58157", "l": "ATP + H2O + 4 Na(+)(in) => ADP + H(+) + 4 Na(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32521", "l": "(E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine => (2E)-geranyl diphosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41438", "l": "cholesteryl (9Z-octadecenoate) + CoA => (9Z)-octadecenoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179417", "l": "Multiubiquitination of Nek2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051401", "l": "CH domain binding", "d": ["Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21647", "l": "ATP + glycerol <=> ADP + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23844", "l": "ATP + sedoheptulose = ADP + D-sedoheptulose 7-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.14", "l": "\"sedoheptulokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59496", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611851", "l": "ADRB2 bind ADR,NAd (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75164", "l": "NAD(+) + UTP => H(+) + NADP(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047598", "l": "7-dehydrocholesterol reductase activity", "d": ["Catalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694442", "l": "CNIH2,3 bind GRIA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008674", "l": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity", "d": ["Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682631", "l": "nsp13 binds DDX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50296", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32801", "l": "urea(out) => urea(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050406", "l": "[acetyl-CoA carboxylase]-phosphatase activity", "d": ["Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22962", "l": "calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30888", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin => 7,8-dihydropteroate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.90", "l": "\"tRNA-dihydrouridine(20a/20b) synthase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58141", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) => AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0050543", "l": "icosatetraenoic acid binding", "d": ["Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684323", "l": "3CLp forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205115", "l": "NGF:p75NTR complex binds to NRAGE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71017", "l": "4-methylaminobutanal + H2O2 + NH4(+) => H2O + N-methylputrescine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982775", "l": "Growth hormone receptor dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825564", "l": "MESP2 binds the EPHA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50644", "l": "2-(3-methylsulfanyl)propylmalate = 3-(3-methylsulfanyl)propylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0097245", "l": "flavanol binding", "d": ["Binding to a flavanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24974", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175976", "l": "TMT transfers CH3 from AdoMet to BME (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166792", "l": "Conversion of C2 into C2a and C2b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174963", "l": "NAT1 acetylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64848", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA = (3Z)-hex-3-en-1-yl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009072", "l": "STAT3 phosphorylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033191", "l": "macrophomate synthase activity", "d": ["Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77094", "l": "Formation of cap binding complex (CBC) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015139", "l": "alpha-ketoglutarate transmembrane transporter activity", "d": ["Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle."], "t": []}, {"i": "REACT:R-HSA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187332", "l": "Cytosolic CMs translocate to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102784", "l": "lutein oxygenase activity", "d": ["Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964274", "l": "G alpha (12) binds BTK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43375", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102877", "l": "alpha-copaene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-copaene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047562", "l": "3-hydroxyaspartate aldolase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018807", "l": "RAC3 GDIs block activation of RAC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41832", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73910", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP <=> ADP + aeruginascin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22505", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26428", "l": "ADP + CTP + 2 H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103027", "l": "FMN phosphatase activity", "d": ["Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49134", "l": "an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21319", "l": "H2O + phorbol 12,13-dibutanoate <=> butanoate + H(+) + phorbol 13-butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22598", "l": "acetate + deacetylcephalosporin C + H(+) => cephalosporin C + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17098", "l": "3-phenylpyruvate => enol-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48954", "l": "14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH => 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60672", "l": "NAD(+) + nerol = H(+) + NADH + neral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14385", "l": "a dolichyl diphosphate + H2O = a dolichyl phosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.43", "l": "\"dolichyldiphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30364", "l": "fumonisin B1 + 2 H2O => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33570", "l": "A + ethanol <=> acetaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11454", "l": "H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31194", "l": "(3S)-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71778", "l": "acetoacetate(out) + H(+)(out) <=> acetoacetate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018758", "l": "RHOH binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139917", "l": "tBID activates BAX protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788622", "l": "p-Y-STATs dimerize (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70600", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418451", "l": "cGMP stimulates Protein Kinase G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635839", "l": "ULK3:SUFU dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210430", "l": "Release of L-Glutamate at the synapse (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26337", "l": "L-homocysteine + S-methyl-L-methionine = H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62638", "l": "an alcohol + H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] => a hydroperoxide + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45608", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53373", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) => H(+) + NADH + uridine(17) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67140", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 = H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032798", "l": "DOCK3 activates RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432067", "l": "Aquaporin-4 passively transports water out of cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10759", "l": "ATP + phosphate + pyruvate <=> AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830270", "l": "Protein M2-1 forms tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69271", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate <=> an alkenyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60737", "l": "(2E,6E)-farnesal + H2O + NADP(+) => (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198314", "l": "DAG stimulates protein kinase C-delta (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70971", "l": "citrate <=> isocitrate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21684", "l": "(R)-beta-alanopine + H2O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.26", "l": "\"beta-alanopine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25617", "l": "terpentedienyl diphosphate = diphosphate + terpentetriene", "d": [], "t": []}, {"i": "EC:4.2.3.36", "l": "\"terpentetriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24795", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53036", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45070", "l": "CoA + O-acyl-(R)-carnitine => (R)-carnitine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42800", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) = all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40057", "l": "2,3-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27729", "l": "5-dehydro-4-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43181", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75565", "l": "cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cyathadiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045551", "l": "cinnamyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008551", "l": "P-type cadmium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034700", "l": "allulose 6-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018112", "l": "proline racemase activity", "d": ["Catalysis of the reaction: L-proline = D-proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662466", "l": "XYLB phosphorylates D-xylulose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862184", "l": "USP48 cleaves polyubiquitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221061", "l": "TDG excises 5-carboxylcytosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75144", "l": "prosolanapyrone III => solanapyrone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047394", "l": "glycerophosphoinositol inositolphosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57883", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62091", "l": "D-glucosamine 6-phosphate + NADP(+) <=> 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75742", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH <=> 10-oxooctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24938", "l": "H2O + imidazol-4-one <=> N-formimidoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202168", "l": "Phosphorylation of ZAP-70 by Lck (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41202", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870465", "l": "RGGT binds the RAB-binding subunit (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70037", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol => 6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17943", "l": "2-methyl-cis-aconitate + H2O => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047056", "l": "(S)-canadine synthase activity", "d": ["Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693198", "l": "RHOD binds effectors at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21702", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52282", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25556", "l": "9alpha-copalyl diphosphate = diphosphate + stemod-13(17)-ene", "d": [], "t": []}, {"i": "EC:4.2.3.34", "l": "\"stemod-13(17)-ene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21348", "l": "8 H(+) + 10 malonyl-CoA = 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": [], "t": []}, {"i": "EC:2.3.1.235", "l": "\"tetracenomycin F2 synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043716", "l": "2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13151", "l": "AH2 + NADP(+) => A + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67328", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione = trichosetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0070529", "l": "L-tryptophan aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635854", "l": "GLI2,3 are degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.87", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693609", "l": "ATM phosphorylates TP53 at S15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77007", "l": "(2S)-5,5-dimethylpiperidine-2-carboxylate + 10-hydroxy-pre-flavunoidine + ATP = AMP + diphosphate + flavunoidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088130", "l": "PLK1 binds FOXM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19831", "l": "an aldehyde + H2O2 => a primary alcohol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50802", "l": "prostaglandin A2-S-(S)-glutathione => glutathione + prostaglandin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210439", "l": "glutamate uptake by astrocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070594", "l": "juvenile hormone response element binding", "d": ["Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50487", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371467", "l": "SIRT1 deacetylates HSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647632", "l": "CASP3 cleaves GSDME (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73557", "l": "(E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514854", "l": "CDK1 phosphorylates condensin I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61131", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.146", "l": "\"(iso)eugenol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10828", "l": "anthranilate + ATP + CoA = AMP + anthraniloyl-CoA + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.32", "l": "\"anthranilate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61592", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": [], "t": []}, {"i": "EC:1.8.98.7", "l": "\"cysteine-type anaerobic sulfatase-maturating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63052", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44901", "l": "D-galactono-1,4-lactone + H2O => D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369028", "l": "ABCAs mediate lipid efflux (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961934", "l": "CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109701", "l": "PDPK1 binds PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68063", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42667", "l": "alpha-L-arabinopyanose + NADP(+) <=> H(+) + L-arabinono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58686", "l": "FADH2-C4alpha-hydroperoxide + NADP(+) => FAD + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64787", "l": "S-ethyl-L-cysteine <=> 2-aminoprop-2-enoate + ethanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73806", "l": "AIR + CO2 => CAIR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709396", "l": "CO translocates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39743", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641134", "l": "SMURF2 binds AXIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021949", "l": "MEF2C gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004956", "l": "prostaglandin D receptor activity", "d": ["Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14071", "l": "5-dehydro-D-fructose + H(+) + NADPH => D-fructose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20967", "l": "2-oxoglutarate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871373", "l": "BMX phosphorylates RUFY1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1990088", "l": "[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase", "d": ["Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-coenzyme M + a [Co(I) methanol-specific corrinoid protein] + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209925", "l": "DIT and MIT combine to form triiodothyronine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53458", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649733", "l": "mature p21 RAS binds GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828715", "l": "F mRNA is translated into nascent protein F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030955", "l": "potassium ion binding", "d": ["Binding to a potassium ion (K+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13097", "l": "a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.59", "l": "\"3-hydroxyacyl-[acyl-carrier-protein] dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69630", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59535", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74505", "l": "H2O + NADP(+) + penigequinolone B => H(+) + NADPH + yaequinolone D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444661", "l": "HCAR2 binds HCAR2 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46232", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0032553", "l": "ribonucleotide binding", "d": ["Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624953", "l": "ARL13B binds INPP5E (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340226", "l": "CYGB dioxygenates NO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45412", "l": "H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60967", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76948", "l": "3-methyl-2-aminobutane + H2O + NADP(+) => 3-methylbutan-2-one + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21587", "l": "NAD(+) + propane-1,2-diol 1-phosphate <=> H(+) + hydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744886", "l": "The Ligand:GPCR:Gs complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61538", "l": "ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55378", "l": "2 a quinone + 2 H2O => 2 a quinol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396083", "l": "Laminins bind galactosyl sulfatide and related sulfated glycolipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71099", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804998", "l": "p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71572", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) => 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13147", "l": "alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine => 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013438", "l": "RHOD binds effectors at the endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63532", "l": "angiotensin I + H2O = angiotensin-(1-9) + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11854", "l": "adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265177", "l": "Exocyst complex formation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70987", "l": "beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186780", "l": "PI3-kinase binds to the active receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18006", "l": "D-threitol + NADP(+) => D-erythrulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69122", "l": "3-phenylpyruvate + glycine => glyoxylate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17507", "l": "a long-chain fatty acid + ethanolamine => H2O + N-(long-chain fatty acyl)ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10843", "l": "H2O + O-phospho-L-homoserine <=> L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23814", "l": "(1R,4S)-menthone + H(+) + NADPH => (+)-neomenthol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57251", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP <=> dGTP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610723", "l": "GLI proteins bind SUFU (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74451", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54348", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534160", "l": "HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59951", "l": "H2O + prostaglandin F2alpha-CoA <=> CoA + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49265", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O => (E)-caffeate + H(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45703", "l": "glycine betaine + H(+) + NADH + O2 <=> formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432054", "l": "Aquaporin-1 passively transports water out of cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676160", "l": "AAMP binds NOD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74769", "l": "3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51864", "l": "(2E)-geranyl diphosphate + esculetin = 8-geranylesculetin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031849", "l": "olfactory receptor binding", "d": ["Binding to an olfactory receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73285", "l": "H(+)(in) + L-isoleucine(out) => H(+)(out) + L-isoleucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.3", "l": "\"2-acetolactate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354066", "l": "Translocation of PTK2 to Focal complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210300", "l": "Interaction of DAP12 and TREM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15697", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371422", "l": "ATP hydrolysis by HSP70 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382058", "l": "Nck binds to the active PDGF receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40998", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA <=> 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.59", "l": "\"tryptase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159253", "l": "MMAB adenosylates cob(I)alamin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687465", "l": "MRN complex binds RBBP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858270", "l": "HILPDA binds lipid droplets (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52927", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52767", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O <=> (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62911", "l": "nor-toralactone + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13549", "l": "beta-L-fucose 1-phosphate + GTP + H(+) = diphosphate + GDP-beta-L-fucose", "d": [], "t": []}, {"i": "EC:2.7.7.30", "l": "\"fucose-1-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23671", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9817575", "l": "ERO1B oxidizes P4HB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788623", "l": "p-Y-STATs translocate to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444100", "l": "PROT mediates L-proline uptake (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38800", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005369", "l": "taurine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28690", "l": "(S)-dihydroorotate + ubiquinone-8 <=> orotate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.6", "l": "\"leucine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66914", "l": "avenanthramide B + H(+) + S-adenosyl-L-homocysteine => avenanthramide C + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218804", "l": "p38 MAPK activation by VEGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043992", "l": "histone H3K9 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034878", "l": "2-hydroxyisonicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75732", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) => 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030229", "l": "very-low-density lipoprotein particle receptor activity", "d": ["Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404135", "l": "RBP4 binds atROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68449", "l": "13-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13028", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48271", "l": "4',4'-dihydroxyechinenone <=> canthaxanthin + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30252", "l": "2 a ubiquinol + n H(+)(in) + O2 => 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66591", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474266", "l": "Formation of collagen fibrils (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46891", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851098", "l": "NPM1-ALK- and JUN-dependent CDKN1A gene repression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25827", "l": "H2O + O2 + spermine <=> H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37305", "l": "ADP + glycyl-L-asparagine(in) + H(+) + phosphate => ATP + glycyl-L-asparagine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49018", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => aurachin C epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421158", "l": "xanthine + H2O + NAD+ => urate + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30551", "l": "acetyl-CoA + beta-D-glucose = 6-O-acetyl-beta-D-glucose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65064", "l": "dimethylallyl diphosphate + siccayne = diphosphate + pestalodiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26282", "l": "Co-precorrin-5A + H2O => acetaldehyde + Co-precorrin-5B + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75238", "l": "TRAIL binds TRAIL receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428750", "l": "Gq activation by TP receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67794", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA => ribonucleotidyl-uridine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396370", "l": "VTN binds collagens II, III and V (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28619", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 => 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9834821", "l": "p-PRKRA dimer binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40588", "l": "H2O + octanedioyl-CoA => CoA + H(+) + octanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769383", "l": "CBY1 binds beta-catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62008", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35747", "l": "(2E,6E)-farnesyl diphosphate = 7-epizingiberene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.142", "l": "\"7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004895", "l": "cell adhesion receptor activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070034", "l": "telomerase RNA binding", "d": ["Binding to the telomerase RNA template."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130151", "l": "Dimerization of DAP12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193722", "l": "TetraHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44577", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) => 2-all-trans-nonaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446634", "l": "IRAK4 is activated by autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25248", "l": "(R)-S-lactoylglutathione + H2O <=> (R)-lactate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66827", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29442", "l": "Fe(2+)(in) + H(+)(out) <=> Fe(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212356", "l": "Formation of CSL-NICD coactivator complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63004", "l": "(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52052", "l": "9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59815", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031728", "l": "CCR3 chemokine receptor binding", "d": ["Binding to a CCR3 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66380", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O = ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61665", "l": "(2E,6E,10E)-geranylgeraniol + ATP => (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46621", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39457", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62854", "l": "GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68120", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467811", "l": "Separation of sister chromatids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47305", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54220", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43953", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.14", "l": "\"5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18171", "l": "glyoxylate + pyruvate => 4-hydroxy-2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047898", "l": "formate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610732", "l": "GSK3 phosphorylates p-GLI3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71934", "l": "fumarate(out) + 3 Na(+)(out) <=> fumarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171288", "l": "Cleavage of the viral Env gp160 precursor polyprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140376", "l": "innate immune receptor activity", "d": ["Receiving a signal and transmitting it in a cell to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56869", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30261", "l": "2 a menaquinone + n H(+)(out) + 2 H2O(in) => 2 a menaquinol + n H(+)(in) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70000", "l": "L-threonine(in) + Na(+)(in) => L-threonine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27579", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + tert-butylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211959", "l": "CYP3A43 6b-hydroxylates TEST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61914", "l": "ADP + H(+) + phosphate + voriconazole(out) => ATP + H2O + voriconazole(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28232", "l": "(+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50217", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114684", "l": "Phosphorylation of Syntaxin-4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015224", "l": "biopterin transmembrane transporter activity", "d": ["Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57173", "l": "(S)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32421", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2R,4R)-neoisodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15700", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37975", "l": "H(+) + homogentisate + phytyl diphosphate = 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.115", "l": "\"homogentisate phytyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954117", "l": "E2F6:TFDP1 binds EPC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25729", "l": "H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395340", "l": "Formation of hydroxyallysine by LOX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64435", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) <=> H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788867", "l": "FN3K phosphorylates ketosamines (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32171", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.149", "l": "\"phenylacetyl-CoA 1,2-epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29095", "l": "5 H(+)(in) + NADH + ubiquinone-8 = 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25335", "l": "H2O + L-cysteinyl-tRNA(Cys) => H(+) + L-cysteine + tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22515", "l": "3 H(+) + precorrin-8X <=> hydrogenobyrinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18100", "l": "pteridine-2,4,6,7-tetrol <=> H(+) + xanthine-8-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18638", "l": "H2 + NADP(+) => H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30276", "l": "AH2 + H2O2 => A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.88", "l": "\"repressor LexA\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43449", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22886", "l": "4-methylsulfanyl-2-oxobutanoate + glycine => glyoxylate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35035", "l": "4-aminobutanoate(in) = 4-aminobutanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20802", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70402", "l": "3-oxosphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22591", "l": "4-aminobutanal <=> 1-pyrroline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48970", "l": "[thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O => [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617852", "l": "FOXO3,FOXO4,(FOXO1) bind GADD45A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30188", "l": "(S)-dihydroorotate + a quinone => a quinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46659", "l": "androst-4-ene-3,17-dione + H(+) + NADPH <=> 5beta-androstane-3,17-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678327", "l": "MIOX oxidises Ins to GlcA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38143", "l": "carbon disulfide + 2 H2O = CO2 + 2 H(+) + 2 hydrogen sulfide", "d": [], "t": []}, {"i": "EC:3.13.1.5", "l": "\"carbon disulfide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68152", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19691", "l": "(S)-lactaldehyde + dihydroxyacetone phosphate => L-rhamnulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15414", "l": "(2R,3R)-tartrate => H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71455", "l": "goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32429", "l": "(S)-carvone + AH2 => (1R,4S)-isodihydrocarvone + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252133", "l": "ATP6AP1 binds V-ATPase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64958", "l": "dTMP + 2 H(+) + 2 phosphate => dTTP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769141", "l": "NPAS4 translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11272", "l": "a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol", "d": [], "t": []}, {"i": "EC:1.1.5.10", "l": "\"D-2-hydroxyacid dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71086", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) <=> estrone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32515", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33937", "l": "H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203973", "l": "Vesicle budding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53052", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851147", "l": "miR-21 RISC binds DNMT1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56496", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38105", "l": "2-dehydro-3-deoxy-L-galactonate + H2O => L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37277", "l": "L-alanine + L-glutamine => H2O + L-alanyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73663", "l": "(E,E)-piperoyl-CoA + pyrrolidine = CoA + H(+) + piperyline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47824", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] = 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72837", "l": "H(+) + U[3'-5']pAp[3'] => 3',3'-cUAMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015531", "l": "citrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)."], "t": []}, {"i": "RHEA:32123", "l": "citrate(in) + H(+)(in) = citrate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11769", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate => 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35594", "l": "H2 + n sulfur <=> H(+) + hydrogen sulfide + (n-1) sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58318", "l": "cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27657", "l": "2-oxobutanoate + H(+) + pyruvate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62603", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033266", "l": "ABC-type choline transporter activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20894", "l": "butanoyl phosphate + CoA => butanoyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987039", "l": "JAK1 binds IL20RA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018768", "l": "RHOU auto-activates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140806", "l": "SERPINC1 binds SERPINC1 activators (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42069", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH => clavulanate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19619", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41585", "l": "dimethylallyl diphosphate + L-tyrosine => 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.9", "l": "\"nitroquinoline-N-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389756", "l": "AKT interacts and phosphorylates Cot (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791057", "l": "Expression of TSPYL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72691", "l": "Formation of the 43S pre-initiation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112514", "l": "JAK activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202969", "l": "Caspase mediated cleavage of beta-catenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061675", "l": "RBL family protein binding", "d": ["Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004655", "l": "porphobilinogen synthase activity", "d": ["Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63346", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018503", "l": "ESR1:ESTG bind the EBAG9 5' region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.27", "l": "\"thermolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351429", "l": "Association of 53BP1 with gamma H2AX at double strand break (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928657", "l": "MMP2,9 cleave EPHB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050590", "l": "desacetoxyvindoline 4-hydroxylase activity", "d": ["Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67915", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49332", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029473", "l": "Branching and elongation of mother and daughter filaments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008725", "l": "DNA-3-methyladenine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709406", "l": "CO binds to Cytochrome c oxidase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140769", "l": "factor VII -> factor VIIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004013", "l": "adenosylhomocysteinase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549467", "l": "Expression of CRYPTOCHROME-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18220", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine <=> an omega-aminoaldehyde + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20588", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016213", "l": "linoleoyl-CoA desaturase activity", "d": ["Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373707", "l": "Netrin-1 induced DCC clustering (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785213", "l": "LIPC dimer binds heparin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19629", "l": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.42", "l": "\"isocitrate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592278", "l": "Autocatalytic activation of proMMP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59819", "l": "a long-chain fatty acyl-CoA + a sterol <=> a sterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140065", "l": "peptide butyryltransferase activity", "d": ["Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide."], "t": []}, {"i": "RHEA:53912", "l": "butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373724", "l": "Nephrin binds NCK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61550", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47647", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9680443", "l": "ROCK1,2 bind ROCKi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710263", "l": "GZMB cleaves GSDME (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37780", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38672", "l": "sphinganine 1-phosphate(in) => sphinganine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374298", "l": "Opioid receptors bind opioid peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762343", "l": "PREDL:ALB dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14752", "l": "1-hydroxy-2-naphthoate + O2 <=> (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.195", "l": "\"L-ornithine N(5)-monooxygenase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044197", "l": "Rel homology domain binding", "d": ["Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75839", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) = H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061697", "l": "protein-glutaryllysine deglutarylase activity", "d": ["Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:47664", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34365", "l": "diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046556", "l": "alpha-L-arabinofuranosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60772", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 = 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50293", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27935", "l": "(3S)-3-hydroxy-D-aspartate => glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689861", "l": "Recruitment of XPA and release of CAK  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45259", "l": "hexadecanoate(out) <=> hexadecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34132", "l": "neryl diphosphate + olivetolate => cannabinerolate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761027", "l": "ZEB2 binds SP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48487", "l": "a propanoate ester + H2O <=> an aliphatic alcohol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43412", "l": "a D-galactosylceramide + H2O = an N-acyl-sphingoid base + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0016679", "l": "oxidoreductase activity, acting on diphenols and related substances as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.10.-.-", "l": "\"Acting on diphenols and related substances as donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18815", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193668", "l": "p75NTR and RHOA-GDI interact (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47600", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8960973", "l": "RLBP1:11cRAL dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61877", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58415", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35391", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451466", "l": "TRAF6 binding to activated IRAK2 stimulates its oligomerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30454", "l": "(S)-2,3-epoxysqualene <=> isomultiflorenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45986", "l": "9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16766", "l": "D-mannitol + NADP(+) => D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44478", "l": "1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40940", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH => 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432143", "l": "PECAM-1 binds PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37923", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868236", "l": "BAR domain proteins recruit dynamin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42007", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67132", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28600", "l": "acetate + L-lysine => H2O + N-acetyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296244", "l": "SUCNR1 binds SUCCA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60708", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13818", "l": "[protein]-disulfide + H2O + phylloquinone => 2,3-epoxyphylloquinone + [protein]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659998", "l": "Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876472", "l": "NPC2 binds CHOL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927886", "l": "SUMOylation of NCOR2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033403", "l": "UUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.61", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168638", "l": "Activated IKK phosphorylates I-kappaB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29439", "l": "Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800797", "l": "The PIDDosome activates CASP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45185", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803719", "l": "TP53 binds ZNF385A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77180", "l": "(5'S,6'R)-C-glycyluridine + O2 => CO2 + H2O + uridine-5'-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73859", "l": "1-methylnicotinamide(out) = 1-methylnicotinamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50398", "l": "2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O => (2-aminobenzoyl)acetate + H(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72951", "l": "butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043863", "l": "4-hydroxy-2-ketopimelate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30203", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964284", "l": "BTK in active Gq-BTK complex is activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70381", "l": "CoA + H(+) + N-tetradecanoyl-3-oxosphinganine => 3-oxosphinganine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67853", "l": "FMNH2 + O2 => FMN-N(5)-peroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549129", "l": "OCT1 transports organic cations into hepatic cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15167", "l": "glyoxylate + H2O2 + methylamine => H2O + O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35017", "l": "riboflavin(out) => riboflavin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395764", "l": "atREs binds to nascent CM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669158", "l": "NF2 binds PAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170159", "l": "Translocation of Cdc25 to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694522", "l": "Inner coat assembly and cargo binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66736", "l": "ATP + beta-citrylglutamate(in) + H2O = ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004741", "l": "[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45457", "l": "H2O + N-dodecanoylethanolamine => dodecanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59075", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31956", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45065", "l": "H2O + N-hexadecanoylethanolamine => ethanolamine + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47899", "l": "6-sulfo-D-quinovose + NAD(+) <=> 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168637", "l": "CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680349", "l": "CSF1R dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13404", "l": "(2E,6E)-farnesol <=> (2Z,6E)-farnesol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47503", "l": "cholate + NADP(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57175", "l": "(S)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12154", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+) => (3R,4S,5S,6R)-pentachlorocyclohexene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69802", "l": "D-tryptophanyl-tRNA(Trp) + H2O <=> D-tryptophan + tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.51", "l": "\"cruzipain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033928", "l": "mannan 1,4-mannobiosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13841", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) = Fe(III)2-[transferrin] + NADH", "d": [], "t": []}, {"i": "EC:1.16.1.2", "l": "\"diferric-transferrin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730904", "l": "Auto-ubiquitination of TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53015", "l": "2,5-dichlorohydroquinone + 2 glutathione <=> chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804379", "l": "PRMT5 binds TTC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75173", "l": "GDP + H(+) + NADP(+) => GTP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018479", "l": "benzaldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0048258", "l": "3-ketoglucose-reductase activity", "d": ["Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67446", "l": "a long-chain fatty aldehyde + formyl-CoA => an (R)-2-hydroxy-long-chain-fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62232", "l": "a thymidine(6-4)thymidine in DNA = a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72791", "l": "bilirubin-glucuronoside(out) = bilirubin-glucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38648", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62777", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63851", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 <=> 2 3',4'-dihydroxyaurone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72441", "l": "(E)-feruloyl-AMP + diphosphate => (E)-ferulate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36820", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11697", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830805", "l": "Nascent sG localizes to ER lumen, gets glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0009931", "l": "calcium-dependent protein serine/threonine kinase activity", "d": ["Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23320", "l": "D-tryptophan + malonyl-CoA = CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": [], "t": []}, {"i": "EC:2.3.1.112", "l": "\"D-tryptophan N-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033736", "l": "L-lysine 6-oxidase activity", "d": ["Catalysis of the reaction: L-lysine + H2O + O2 = allysine + H2O2 + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604731", "l": "Autocatalytic activation of MMP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26195", "l": "(S)-malyl-CoA + ADP + phosphate => (S)-malate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15341", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.6.1.2", "l": "\"cobaltochelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13591", "l": "3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate => 3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003852", "l": "2-isopropylmalate synthase activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374173", "l": "AGT(34-41) binds to AGTR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24488", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14920", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252001", "l": "ATP1B4 binds SNW1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226012", "l": "Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70130", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16182", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16002", "l": "H(+) + H2O + N(6)-methyl-AMP => IMP + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20124", "l": "ATP + L-glutamine + tRNA(Gln) <=> AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41282", "l": "H2O + N-octadecanoylsphing-4-enine <=> octadecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49716", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.223", "l": "\"3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17182", "l": "a long-chain fatty aldehyde + FMNH2 + O2 => a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76955", "l": "2-methylbutanamine + H2O + NAD(+) = 2-methylbutanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701147", "l": "TRPV1 binds TRPV1 blockers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033809", "l": "anthocyanin 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38931", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66597", "l": "O2 + 2 tyramine => 2 dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0097493", "l": "structural molecule activity conferring elasticity", "d": ["The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75272", "l": "S-adenosyl-L-methionine + serotonin => 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54282", "l": "(3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68569", "l": "N(5)-hydroxy-L-ornithine => (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54909", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (4E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71192", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) => an L-alpha-amino acid(out) + L-kynurenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58729", "l": "adenosine in rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086083", "l": "SUMOylation of ING2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38889", "l": "hexanoate + sphinganine => H2O + N-hexanoyl-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75875", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.389", "l": "\"[methyl-Co(III) quaternary-amine-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36888", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341072", "l": "SUMOylation of RARA with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31753", "l": "7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59600", "l": "5-methoxytryptamine + H2O + O2 = 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391936", "l": "EP1 receptor can bind PGE2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39087", "l": "decanedioyl-CoA + O2 = (2E)-decenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19128", "l": "glyoxylate + L-serine <=> 3-hydroxypyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57350", "l": "3-hydroxy-4-methylanthranilate + H(+) + L-alanine => 3-hydroxy-4-methyl-L-kynurenine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55741", "l": "H2O + oleuropein => D-glucose + oleuropein aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050099", "l": "methylglutamate dehydrogenase activity", "d": ["Catalysis of the reaction: N-methyl-L-glutamate + A + H2O = L-glutamate + AH(2) + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34886", "l": "ATP + H2O + selenate(out) <=> ADP + H(+) + phosphate + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47314", "l": "15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51439", "l": "acetyl-CoA + D-alanine <=> (2R)-2-amino-4-oxopentanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49274", "l": "calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062203", "l": "Viteagnusin D synthase activity", "d": ["Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D."], "t": []}, {"i": "RHEA:62180", "l": "H2O + peregrinol diphosphate = diphosphate + viteagnusin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31709", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28363", "l": "dGTP + H2O => dGMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69355", "l": "2 (E)-prop-1-en-1-SO-peroxol <=> H2O + thiosulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20351", "l": "2-hydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39451", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA = (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198669", "l": "p38MAPK phosphorylates MSK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23941", "l": "D-gluconate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.350", "l": "\"menaquinone C(8)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37632", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24327", "l": "6-oxocineole + H(+) + NADPH + O2 <=> 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70272", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36072", "l": "6-tuliposide A => D-glucose + tulipalin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25338", "l": "H(+) + urea = isocyanate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686625", "l": "LAIR1 binds collagen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050275", "l": "scopoletin glucosyltransferase activity", "d": ["Catalysis of the reaction: scopoletin + UDP-D-glucose = H+ + scopolin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77589", "l": "Recognition of AAUAAA sequence by CPSF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848758", "l": "PTK6 phosphorylates AKT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008755", "l": "O antigen polymerase activity", "d": ["Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852019", "l": "MET bound PI3K generates PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199014", "l": "CD96 binds PVR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67772", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O = a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22823", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2467775", "l": "Autocleavage of ESPL1 (Separase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39736", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55615", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O <=> 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.23", "l": "\"lipopolysaccharide heptosyltransferase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51616", "l": "ATP + formate + H(+) = CO2 + dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38261", "l": "glyoxylate + propanoyl-CoA => (2R,3S)-beta-methylmalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46964", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.1.436", "l": "\"lactate dehydrogenase (NAD(+),ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203613", "l": "depalmitoylation of eNOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696605", "l": "USP12, USP26 deubiquitinate AR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53046", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43511", "l": "2,5-diformylfuran + H2O <=> 2-(dihydroxymethyl)-5-formylfuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035991", "l": "nitric oxide sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72605", "l": "(E)-sinapoyl-AMP + diphosphate => (E)-sinapate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53100", "l": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.4", "l": "\"tripeptide aminopeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004924", "l": "oncostatin-M receptor activity", "d": ["Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381309", "l": "PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709360", "l": "H2O2 reduces MetHb (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22121", "l": "CoA + GTP + succinate => GDP + phosphate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694427", "l": "MIA3 binds procollagen VII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42399", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42127", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> androsterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18588", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170979", "l": "(Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32619", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76468", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin B2 => 8-demethyltetracenomycin C + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76643", "l": "xanthine(out) = xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177937", "l": "Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693540", "l": "MRN activates ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62791", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> aurasperone B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.26", "l": "\"DNA alpha-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22370", "l": "D-xylulose 5-phosphate => L-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39109", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848751", "l": "PTK6 binds AKT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984606", "l": "Kinesin-5 is a homotetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22218", "l": "3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+) => (E)-caffeate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42119", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52235", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.-", "l": "\"Serine endopeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0106019", "l": "phosphatidylinositol-4,5-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692738", "l": "HRH2 binds HRH2 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64571", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65856", "l": "A + a 1-hydroxy-3-oxo steroid = a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38178", "l": "all-trans-retinol + hexadecanoyl-CoA <=> all-trans-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937034", "l": "IRAK1 phosphorylates Pellino (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611277", "l": "P2RY12 binds P2RY12 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851988", "l": "BTN2A2 binds T cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45807", "l": "ATP + hydroxylamine + L-glutamate <=> ADP + L-glutamine hydroxamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.137", "l": "\"arsenite methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693111", "l": "RHOF auto-activates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67765", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205238", "l": "SHP2 interacts with p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40183", "l": "O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35502", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047713", "l": "galactitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: galactitol + NAD+ = D-tagatose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141367", "l": "Myristoylation of tBID by NMT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13858", "l": "a dolichyl beta-D-glucosyl phosphate + H2O => a dolichyl phosphate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43434", "l": "butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) => butan-1-ol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400143", "l": "Fatty acid ligands activate PPARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61619", "l": "H(+) + L-proline betaine + NADH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42654", "l": "diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77701", "l": "a ganglioside GT1balpha  (d18:1(4E)) + CMP + H(+) => a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17763", "l": "an aromatic aldehyde + H(+) + NADPH => an aromatic primary alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004746", "l": "riboflavin synthase activity", "d": ["Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34607", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine = a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021357", "l": "PRKCI phosphorylates ELF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332359", "l": "Active calmodulin binds CAMK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21156", "l": "(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.20", "l": "\"phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203567", "l": "palmitoylation of eNOS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36914", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369080", "l": "PRLR binds STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047243", "l": "flavanone 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16802", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] => adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16021", "l": "oxaloacetate = enol-oxaloacetate", "d": [], "t": []}, {"i": "EC:5.3.2.2", "l": "\"oxaloacetate tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803890", "l": "SFN dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58002", "l": "(20S)-ginsenoside Rg3 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047455", "l": "16-alpha-hydroxyprogesterone dehydratase activity", "d": ["Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71292", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) => (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55294", "l": "H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine => pseudouridine(54) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.161", "l": "\"oligosaccharide 4-alpha-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034070", "l": "aminoglycoside 1-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66261", "l": "CoA + IC-asc-C7-AMP => AMP + H(+) + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0016504", "l": "peptidase activator activity", "d": ["Binds to and increases the activity of a peptidase."], "t": []}, {"i": "REACT:R-HSA-168865", "l": "NA activation of TGF-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49172", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28166", "l": "5-nitroanthranilate + H(+) + H2O = 5-nitrosalicylate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.8", "l": "\"5-nitroanthranilic acid aminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509831", "l": "ITPA hydrolyses XTP to XMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11536", "l": "choline + H2O + 2 O2 = glycine betaine + H(+) + 2 H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.17", "l": "\"choline oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35714", "l": "acetate + succinyl-CoA <=> acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008675", "l": "2-dehydro-3-deoxy-phosphogluconate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161293", "l": "Tropoelastin forms aggregate globules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30521", "l": "diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine => GTP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64797", "l": "H2O + L-lysine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61572", "l": "(11Z,14Z)-eicosadienoate + O2 = (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77107", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001064", "l": "cellooligosaccharide binding", "d": ["Binding to cellooligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172433", "l": "Collagen type XIX degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514865", "l": "cGMP dissociates from CNG channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32275", "l": "4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.262", "l": "\"4-hydroxythreonine-4-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48845", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43795", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649733", "l": "mature p21 RAS binds GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55175", "l": "2-oxoglutarate + hexanoyl-CoA + O2 <=> 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58948", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203774", "l": "Interaction of Csk with PAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65345", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA => (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45237", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28023", "l": "ATP + holo-[ACP] + octanoate => AMP + diphosphate + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176452", "l": "Degradation of ubiquitinated SMAD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55002", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58569", "l": "15alpha-stemmadenine + acetyl-CoA => CoA + O-acetyl-15alpha-stemmadenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33326", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728150", "l": "SLC5A2 binds gliflozins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211924", "l": "CYP4B1 12-hydroxylates ARA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878654", "l": "ACP6 hydrolyses MYS-LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26045", "l": "CoA + N-acetyl-9-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16421", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.5", "l": "\"aldehyde ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54150", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40509", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694261", "l": "nsp9 forms a homotetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29824", "l": "chloride(in) => chloride(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3899291", "l": "SUMOylation of EP300 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199299", "l": "AKT phosphorylates FOXO transcription factors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22967", "l": "H(+) + L-ornithine <=> CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36664", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA => (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10832", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.50", "l": "\"glycosylphosphatidylinositol phospholipase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74701", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O => (5R)-hydroxy-beta-trans-bergamotene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617179", "l": "PRKACA phosphorylates TNNI3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73292", "l": "H(+)(out) + L-valine(in) => H(+)(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68611", "l": "Formation of ORC(1-5) complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10848", "l": "an [alpha-factor](in) + ATP + H2O = ADP + an [alpha-factor](out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.7", "l": "\"ABC-type alpha-factor-pheromone transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.38", "l": "\"glutamin-(asparagin-)ase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660662", "l": "ASC binds Caspase-8 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35660", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose => GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48853", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013979", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30537", "l": "biotin + H2O + NADP(+) => biotinate sulfoxide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2328037", "l": "Fibrillin-1 binds integrins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30381", "l": "(+)-beta-chamigrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625901", "l": "CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48694", "l": "H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58239", "l": "L-tyrosyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16460", "l": "(2R,3S)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.175", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12295", "l": "ATP + L-serine + tRNA(Ser) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18662", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) => H(+) + L-ornithine + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25752", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694401", "l": "E protein gets palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42780", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.183", "l": "\"18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167429", "l": "The receptor:G-protein complex  binds GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65072", "l": "(2E,6E)-farnesyl diphosphate = dauca-4,7-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666178", "l": "RTKN binds RHOA, RHOC or RHOB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14161", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.53", "l": "\"acireductone dioxygenase (Ni(2+)-requiring)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218814", "l": "PAK2 autophorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23353", "l": "2-oxoglutarate + 4-aminobutanoate => L-glutamate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218821", "l": "PDK1 phosphorylates PKC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68752", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31873", "l": "alpha-seco-amyrin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12726", "l": "D-iditol + NAD(+) => H(+) + keto-D-sorbose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16545", "l": "formyl-CoA + oxalate = formate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34037", "l": "6'-oxoparomamine + H2O2 => O2 + paromamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74519", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O = beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015540", "l": "3-hydroxyphenyl propionate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24450", "l": "monoglucosyl-enterobactin + UDP => enterobactin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848829", "l": "CBL autoubiquitinates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72122", "l": "(R)-carnitine(in) + glycine betaine(out) <=> (R)-carnitine(out) + glycine betaine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449087", "l": "CD4 binds Interleukin-16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37190", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69405", "l": "uracil(in) => uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49625", "l": "ATP + erythritol => ADP + D-erythritol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803719", "l": "TP53 binds ZNF385A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944026", "l": "SNAI1,SNAI2 bind the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16054", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine => H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40274", "l": "O2 + tetradecanedioyl-CoA <=> (2E)-tetradecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53594", "l": "1-tetradecanoyl-sn-glycerol + phosphate => 1-tetradecanoyl-sn-glycerol 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51257", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 => (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54036", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) = [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": [], "t": []}, {"i": "EC:1.20.4.3", "l": "\"mycoredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030108", "l": "HLA-A specific activating MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38038", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate <=> (4Z)-2-oxohept-4-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9846477", "l": "A4GALT transfers galactose to LacCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192841", "l": "Viral Protein Synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784861", "l": "HSPG binds LPL dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19035", "l": "an N-acyl-D-mannosamine => an N-acyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22134", "l": "ADP + D-maltose(in) + H(+) + phosphate => ATP + D-maltose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32552", "l": "(2E)-geranyl diphosphate + H2O => (S)-alpha-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68593", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O => (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20186", "l": "a CMP-N-acyl-beta-neuraminate + H2O => an N-acylneuraminate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44391", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30844", "l": "H2O + N-formylmaleamate => formate + H(+) + maleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56060", "l": "H(+) + hexadecanoate + hnu = CO2 + pentadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032559", "l": "adenyl ribonucleotide binding", "d": ["Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141040", "l": "very-long-chain 3-oxoacyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH. This reaction is the second (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011997", "l": "ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66153", "l": "acetyl-CoA + noradrenaline => CoA + H(+) + N-acetylnoradrenaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201622", "l": "Caspase-mediated cleavage of gelsolin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72473", "l": "citrate(in) + D-threo-isocitrate(out) => citrate(out) + D-threo-isocitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63494", "l": "menadiol + NADP(+) => H(+) + menadione + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59112", "l": "ATP + L-serine = ADP + H(+) + O-phospho-L-serine", "d": [], "t": []}, {"i": "EC:2.7.1.225", "l": "\"L-serine kinase (ATP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655170", "l": "RCHY1 monoubiquitinates POLH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56875", "l": "(S)-N-acetyl-1-phenylethylamine + H2O <=> (S)-1-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432483", "l": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380949", "l": "AMPK is dephosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166038", "l": "GPI-bound CD14 binds LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16134", "l": "H2O + N(1)-acetylspermine + O2 => 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799431", "l": "TP53 binds HIPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34753", "l": "ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => ATP + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15705", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA = 2 a ubiquinol + phenylglyoxylyl-CoA", "d": [], "t": []}, {"i": "EC:1.17.5.1", "l": "\"phenylacetyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928623", "l": "EPHBs bind NMDARs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18972", "l": "a long-chain fatty acid + H(+) + hnu <=> a long-chain alkane + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56953", "l": "CTP + pyruvate => CDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10392", "l": "(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30820", "l": "allantoin + H2O => allantoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37003", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61204", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal = H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.163", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47886", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050030", "l": "L-pipecolate dehydrogenase activity", "d": ["Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32375", "l": "limonene-1,2-diol + NAD(+) = 1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139941", "l": "Binding of IP3 to IP3 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45157", "l": "3-oxopropanoyl-CoA + H2O => 3-oxopropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750942", "l": "USP14 deubiquitinates NLRC5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052760", "l": "coenzyme F420-dependent 2,4-dinitrophenol reductase activity", "d": ["Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052658", "l": "inositol-1,4,5-trisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102802", "l": "thebaine 6-O-demethylase activity", "d": ["Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45694", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(out) => N-(octanoyl)-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10237", "l": "trans-2-coumarate + UDP-alpha-D-glucose => H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22858", "l": "(7S)-O-acetylsalutaridinol + CoA => (7S)-salutaridinol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450551", "l": "AUF1 binds translation and heat shock proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55829", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73613", "l": "CTP(in) + dCDP(out) => CTP(out) + dCDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13319", "l": "(R)-glycerate + CO2 => (2R,3R)-tartrate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75582", "l": "A + cyathatriol <=> AH2 + cyathin A3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814764", "l": "Plasma membrane resorption (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53361", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) => H(+) + NADPH + uridine(47) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017017", "l": "MAP kinase tyrosine/serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47607", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GP1calpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69097", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine => H2O + kynurenate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74620", "l": "CMP(in) + UMP(out) => CMP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65399", "l": "8-oxo-dATP + H2O <=> 8-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963578", "l": "SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788999", "l": "HV1-mediated H+ transfer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689630", "l": "BAP1 binds BAP1-interacting complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353524", "l": "XP-C binds to RAD23B forming a heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940100", "l": "CDK1 phosphorylates VCPIP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45569", "l": "[heparosan](n) => [acharan](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54026", "l": "(3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32189", "l": "cholest-4-en-3-one => cholest-5-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65252", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein = diphosphate + verruculide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033715", "l": "nucleoside oxidase activity", "d": ["Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749977", "l": "UGT1A6 glucuronates ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66763", "l": "ATP + H2O + kainate(in) <=> ADP + H(+) + kainate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34850", "l": "7,8-dihydromonapterin + H(+) + NADPH <=> 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50223", "l": "(S)-demethyl-4-deoxygadusol <=> (R)-demethyl-4-deoxygadusol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800794", "l": "PIDD1 associates with CRADD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627056", "l": "Procaspase 9 forms dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28359", "l": "FAD + H(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29584", "l": "guanosine(in) + H(+)(out) => guanosine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19049", "l": "(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.81", "l": "\"hydroxylysine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10245", "l": "4-fumarylacetoacetate + H2O => acetoacetate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25408", "l": "ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389083", "l": "Autophosphorylation of PDGF alpha receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677051", "l": "Formation of the PCAF-ATAC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25235", "l": "N-acetyl-beta-neuraminate => N-acetyl-alpha-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40273", "l": "(2E)-tetradecenedioyl-CoA + H2O2 => O2 + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21099", "l": "3-dehydroquinate <=> 3-dehydroshikimate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64024", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15423", "l": "a long-chain fatty acyl-CoA + AMP + diphosphate => a long-chain fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.-.-", "l": "\"Glycosylases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22563", "l": "(3R)-vestitone + NADP(+) <=> 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22115", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44895", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose <=> an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40936", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54481", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18302", "l": "ATP + NH4(+) + XMP => AMP + diphosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13178", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate => 3-oxopropanoate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56093", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028598", "l": "Phosphorylation of YAP by LATS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419351", "l": "PAF receptor binds platelet activating factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24785", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389762", "l": "Phosphorylation of PD-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37855", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20461", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.344", "l": "\"ornithine lipid N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019215", "l": "intermediate filament binding", "d": ["Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047204", "l": "chlorogenate-glucarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62060", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380949", "l": "AMPK is dephosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140033", "l": "acetylation-dependent protein binding", "d": ["Binding to a protein upon acetylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56032", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.-", "l": "\"Sulfurtransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.4.4", "l": "\"[ribosomal protein uS12] (aspartate(89)-C(3))-methylthiotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111930", "l": "Adenylate cyclase produces cAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048495", "l": "Roundabout binding", "d": ["Binding to Roundabout (ROBO) receptor, a transmembrane receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37363", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66970", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168768", "l": "JAK2 binds STAT1/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67913", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O => 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445699", "l": "ATP Hydrolysis By Myosin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362427", "l": "Hh-Np binds GPC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25378", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA <=> a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58253", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] => ADP-D-ribose + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749215", "l": "MCM8 binds CDC6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654224", "l": "Activated FGFR3 binds PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47912", "l": "6-deoxy-6-sulfo-D-gluconate = 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.162", "l": "\"6-deoxy-6-sulfo-D-gluconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858482", "l": "DVL is recruited to the receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11595", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O <=> dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182795", "l": "RNase H-mediated degradation of the template strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74258", "l": "XDH oxidizes xanthine to form urate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33348", "l": "2-iminoacetate + H2O => glyoxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36663", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA = (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.226", "l": "\"carboxymethylproline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42997", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-cembrene A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666008", "l": "SCAI binds SRF:MKL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937369", "l": "ATAD2 binds ESR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954056", "l": "E2F6 binds TFDP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102667", "l": "indole-3-acetyl-beta-1-D-glucose hydrolase activity", "d": ["Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O = H+ + indole-3-acetate + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008107", "l": "galactoside 2-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38479", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70366", "l": "cyanurate + H2O <=> 1-carboxybiuret + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187828", "l": "Translocation of p21 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37996", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43290", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018798", "l": "RHOV binds GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epi-alpha-bisabolol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55955", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698844", "l": "MLKL binds HSP90:CDC37 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14432", "l": "a [oligopeptide](in) + ATP + H2O <=> a [oligopeptide](out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390112", "l": "Phosphorylated HPO dimer phosphorylates WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58799", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836468", "l": "G protein binds CX3CR1 on host cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61065", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54495", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628901", "l": "TP53 stimulates TIGAR expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13504", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63265", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62834", "l": "GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75079", "l": "Formation of AT-AC C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46138", "l": "2 H2O + NADP(+) + pyrrolnitrin => aminopyrrolnitrin + H(+) + NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21737", "l": "(3S)-3,6-diaminohexanoate => (3S,5S)-3,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209272", "l": "N-HH binds to the transmembrane HSPG proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14098", "l": "3-phenylpyruvate + L-aspartate => L-phenylalanine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10484", "l": "H2O + N-feruloylglycine = (E)-ferulate + glycine", "d": [], "t": []}, {"i": "EC:3.5.1.71", "l": "\"N-feruloylglycine deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.-.-", "l": "\"Catalysing the translocation of other compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56815", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 <=> 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045483", "l": "aristolochene synthase activity", "d": ["Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52970", "l": "H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008667", "l": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity", "d": ["Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ = 2,3-dihydroxybenzoate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32578", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202726", "l": "F11R dimerises (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210282", "l": "Interaction of GPVI and FceRI gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64683", "l": "benzoyl-CoA + ethanol <=> CoA + ethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51637", "l": "a quinone + H2O + selenite => a quinol + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62383", "l": "carbaryl + H(+) + H2O <=> 1-naphthol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210886", "l": "NEUROG3-dependent synthesis of PAX4 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007759", "l": "MSX2 binds RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43760", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047742", "l": "chenodeoxycholoyltaurine hydrolase activity", "d": ["Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043864", "l": "indoleacetamide hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56738", "l": "H(+) + H2O2 + retinoate => H2O + O2 + retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754839", "l": "SARS-CoV-2 9b binds IKBKG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944240", "l": "Association of procollagen type III (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30108", "l": "D-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47771", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66547", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62982", "l": "(9Z)-hexadecenoate + NH4(+) => (9Z)-hexadecenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60692", "l": "(E)-non-2-enal + H2O + NADP(+) = (E)-non-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0003867", "l": "4-aminobutyrate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41696", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15689", "l": "H(+) + L-2,4-diaminobutanoate = CO2 + propane-1,3-diamine", "d": [], "t": []}, {"i": "EC:4.1.1.86", "l": "\"diaminobutyrate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15964", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> H(+) + taxiphyllin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689317", "l": "Formation of the pre-incision complex in GG-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70282", "l": "H2O + stachyose <=> D-galactose + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193801", "l": "Influx of 27-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41540", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.305", "l": "\"8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40692", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol => 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47280", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53909", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833388", "l": "MAVS and DDX58 interact (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54195", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35399", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine = beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.213", "l": "\"cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6'''-O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693012", "l": "TNFSF15 binds TNFRSF25 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54276", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202241", "l": "Recruitment of SLP-76 to Gads (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26302", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => (S)-allantoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682377", "l": "LC3 de-lipidation by ATG4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50584", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65322", "l": "chrodrimanin A + CO2 + succinate => 2-oxoglutarate + chrodrimanin E + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341072", "l": "SUMOylation of RARA with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114552", "l": "Thrombin-activated PARs activate G12/13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66253", "l": "ATP + CoA + IC-asc-C7 => AMP + diphosphate + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75588", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose => erinacine Q2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57505", "l": "3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28740", "l": "Cd(2+)(in) + H(+)(out) => Cd(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29107", "l": "H(+) + NADH + ubiquinone-8 = NAD(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444572", "l": "Zinc is an agonist of GPR39 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35220", "l": "8-oxo-dADP + H2O => 8-oxo-dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186780", "l": "Degradation of Ub-SMAD7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0004448", "l": "isocitrate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49010", "l": "aurachin C epoxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.578880498257753", "identifiers": [{"i": "GO:0016830", "l": "carbon-carbon lyase activity", "d": ["Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14200", "l": "ATP + L-aspartate + NH4(+) <=> ADP + H(+) + L-asparagine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67563", "l": "3'-phosphoadenylyl sulfate + taurocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52776", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.52", "l": "\"camalexin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24007", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39037", "l": "an omega-oxo fatty acid + H(+) + NADH => an omega-hydroxy fatty acid + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:1990043", "l": "5' deoxyribonuclease (pyrimidine dimer) activity", "d": ["Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033927", "l": "glucan 1,4-alpha-maltohexaosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64840", "l": "2-phenylethanol + benzoyl-CoA = CoA + phenethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031870", "l": "thromboxane A2 receptor binding", "d": ["Binding to a thromboxane A2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70047", "l": "2-oxoadipate + L-kynurenine = H2O + kynurenate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619756", "l": "NR1H2 binds ABCA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166753", "l": "Conversion of C4 into C4a and C4b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34505", "l": "(+)-epi-alpha-bisabolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65036", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63557", "l": "dynorphin A-(1-13) + H2O => dynorphin A-(1-12) + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.57", "l": "\"O-sialoglycoprotein endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35338", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA <=> 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30840", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose => UDP-N-acetyl-beta-L-fucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75184", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + lydicene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624668", "l": "CEBPA binds CDKN1A (p21) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34553", "l": "ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate c monoamide + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31503", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate = 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.95", "l": "\"xanthan pyruvate transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55571", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine <=> 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790025", "l": "Expression of BCL2, BCL2L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61813", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose => dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052843", "l": "inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52491", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10270", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 2-dehydro-3-deoxy-D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66570", "l": "preluffariellolide A => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404142", "l": "atROL binds RBP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183055", "l": "Binding of CBL to EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103001", "l": "dimethylsulfoxide oxygenase activity", "d": ["Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ = sulfonyldimethane + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625482", "l": "PTK2 binds activated EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25496", "l": "(2E)-geranyl diphosphate = (1S,5S)-beta-pinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.120", "l": "\"(-)-beta-pinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3159259", "l": "MMAA:MUT binds AdoCbl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858475", "l": "ppDVL recruits RAC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047272", "l": "phosphopolyprenol glucosyltransferase activity", "d": ["Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11032", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+)", "d": [], "t": []}, {"i": "EC:5.5.1.7", "l": "\"chloromuconate cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63745", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-1-N-beta-D-glucuronide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102148", "l": "N-acetyl-beta-D-galactosaminidase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5225649", "l": "RBBP7 binds histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209815", "l": "Tyrosine is monoiodinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134896", "l": "LRR FLII-interacting protein 1 binds dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28851", "l": "melibiose(in) + Na(+)(in) = melibiose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35264", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32253", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186798", "l": "GAP binds to PDGF-beta receptors only (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28031", "l": "[thioredoxin]-disulfide + dGDP + H2O => [thioredoxin]-dithiol + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814831", "l": "TBC1D20 binds RAB1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13909", "l": "phosphate + urate D-ribonucleoside = alpha-D-ribose 1-phosphate + urate", "d": [], "t": []}, {"i": "EC:2.4.2.16", "l": "\"urate-ribonucleoside phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60314", "l": "H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76301", "l": "L-aspartate(out) + L-cystine(in) => L-aspartate(in) + L-cystine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59103", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose <=> H(+) + triglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428749", "l": "Activated TP receptor binds G-proten Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210912", "l": "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28402", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062078", "l": "TSC1-TSC2 complex binding", "d": ["Binding to a TSC1-TSC2 complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66396", "l": "ATP + cholate(in) + glutathione(in) + H2O = ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198611", "l": "AKT phosphorylates IKKalpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20525", "l": "ATP + ethylamine + L-glutamate = ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.6", "l": "\"glutamate--ethylamine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71596", "l": "2-oxoglutarate(out) + succinate(in) => 2-oxoglutarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76755", "l": "decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,3-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029460", "l": "PAK1 phosphorylates LIMK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8863727", "l": "STON2 is neddylated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.63", "l": "\"2-hydroxyacyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35748", "l": "(2E,6E)-farnesyl diphosphate => 7-epizingiberene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31243", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) = (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351876", "l": "Caspase-mediated cleavage of occludin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64697", "l": "benzyl alcohol + NAD(+) => benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73353", "l": "AMP + carcinine + diphosphate + H(+) => ATP + beta-alanine + histamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68546", "l": "(E)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102383", "l": "steviol 19-O glucosyltransferase activity", "d": ["Catalysis of the reaction: steviol + UDP-alpha-D-glucose = 19-O-beta-glucopyranosyl-steviol + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32903", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.24", "l": "\"vitamin D 25-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71031", "l": "L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29153", "l": "3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33486", "l": "an acyl-CoA + ergosterol <=> CoA + ergosteryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49182", "l": "a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine => a bacteriochlorophyllide d + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31357", "l": "formaldehyde + H2O + methanethiol + NAD(+) => dimethyl sulfide + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62113", "l": "(3S)-3-hydroxy-D-aspartate => H2O + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714483", "l": "RAC2 translocates to the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203979", "l": "Coat Assembly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380780", "l": "Activation of Src (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58624", "l": "N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37489", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789092", "l": "NOX2 generates superoxide anion from oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31028", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71145", "l": "(E)-caffeoylpyruvate + CO2 + hnu => 3-hydroxyhispidin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37912", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047640", "l": "aldose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.107", "l": "\"apo-salmochelin esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865505", "l": "SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451283", "l": "kainate receptor binds glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29454", "l": "H2O + phosphonate <=> H2 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77214", "l": "3'-phosphoadenylyl sulfate + taurodeoxycholate <=> 3alpha-sulfotaurodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40221", "l": "CoA + H(+) + malonate => H2O + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43552", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68359", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate <=> L-glutamate + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168046", "l": "Collagen type XII degradation by MMP12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168445", "l": "PTP1B binds the GH receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817254", "l": "DUX4 binds HSATII pericentric repeat (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417896", "l": "P2Y6 receptor can bind to UDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983707", "l": "SYK autophosphorylates at the activated BCR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798374", "l": "DYRK2 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45238", "l": "(25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75450", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661432", "l": "BIL binds ALB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55058", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879909", "l": "Activation of STAT5a/b by JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647977", "l": "ICMT methylates S-Farn RAS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60517", "l": "L-tryptophan => D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61205", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal => H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905201", "l": "gibberellin transmembrane transporter activity", "d": ["Enables the transfer of gibberellin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63115", "l": "A + ascofuranol <=> AH2 + ascofuranone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176318", "l": "Loading of claspin onto DNA during replication origin firing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44638", "l": "2,4-dinitrophenol + H(+) + methanol => 2,4-dinitroanisole + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35032", "l": "L-serine(in) => L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218814", "l": "PAK2 autophorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73549", "l": "GTP(in) + UTP(out) => GTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39560", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22714", "l": "adenosylcob(III)inamide-GDP + diphosphate => adenosylcob(III)inamide phosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44859", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55171", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18320", "l": "an L-alpha-amino acid <=> a D-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32185", "l": "cholest-5-en-3-one + H2O2 => cholesterol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34304", "l": "L-lysine => L-pipecolate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59941", "l": "2-methyloctadecanoyl-CoA + H2O => 2-methyloctadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54625", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA => 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682983", "l": "ATM phosphorylates WHSC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70018", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone <=> 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71675", "l": "glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74194", "l": "carbofuran + H(+) + H2O <=> 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050573", "l": "dTDP-4-dehydro-6-deoxyglucose reductase activity", "d": ["Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694421", "l": "PP6 dephosphorylates SEC24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429719", "l": "MCPH1 sequesters condensin II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374686", "l": "L1 interaction with Integrins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36193", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008110", "l": "L-histidine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56264", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54919", "l": "9-cis-retinol + NADP(+) <=> 9-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627369", "l": "SEPT4 binds XIAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.-.-", "l": "\"Other oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047743", "l": "chlordecone reductase activity", "d": ["Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56709", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168412", "l": "MDP elicits a NOD2 response (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29673", "l": "Ca(2+)(out) => Ca(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769394", "l": "AKT phosphorylates CBY1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226016", "l": "Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50610", "l": "12-oxo-leukotriene B4 + H(+) + NADPH => leukotriene B4 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72726", "l": "UDP-alpha-D-xylose(in) + UMP(out) <=> UDP-alpha-D-xylose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987223", "l": "IL10RB binds TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047642", "l": "aldose beta-D-fructosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0005381", "l": "iron ion transmembrane transporter activity", "d": ["Enables the transfer of iron (Fe) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27440", "l": "2 glutathione amide + H2O2 <=> glutathione amide disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58019", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672817", "l": "Active MTORC1 binds the ULK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902051", "l": "(25S)-Delta(4)-dafachronate binding", "d": ["Binding to (25S)-Delta(4)-dafachronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71679", "l": "H(+)(out) + L-lysyl-glycine(out) = H(+)(in) + L-lysyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082391", "l": "Trimerization of HSF1 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879327", "l": "acetylglucosamine-inositol is deacetylated by Mca (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876255", "l": "CBL recruits CIN85:endophilin complex to InlB-bound MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60315", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68706", "l": "3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75523", "l": "acetyl-CoA + S-methyl-L-cysteine = CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021935", "l": "SST gene expression is stimulated by MECP2 and CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20808", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801109", "l": "CHM binds RGGT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372425", "l": "fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44498", "l": "2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749197", "l": "ORC1 binds to H4K20me2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75557", "l": "erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21369", "l": "H2O + O2 + urate => 5-hydroxyisourate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390078", "l": "14-3-3 dimer binds to phosphorylated YKI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362465", "l": "GHBP binds GHR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46410", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042071", "l": "leucokinin receptor activity", "d": ["Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44221", "l": "15-hydroxypentadecanoate + ATP + CoA => 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30915", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73983", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-barbatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63316", "l": "(9Z,12Z)-octadecadienoate + O2 = 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66550", "l": "4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate => 3'-phosphoadenylyl sulfate + 4-nitrophenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68170", "l": "2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694419", "l": "SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432164", "l": "Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008467", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009824", "l": "AMP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43532", "l": "a ribonucleoside 3',5'-bisphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.97", "l": "\"3',5'-nucleoside bisphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50658", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 3-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30856", "l": "dammarenediol-II => (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73724", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate => (2R,3S,11S)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.65", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69431", "l": "arsenite + 3 glutathione + H(+) <=> arsenic triglutathione + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10676", "l": "(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052765", "l": "reduced coenzyme F420 oxidase activity", "d": ["Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603419", "l": "Activated NTRK3 binds SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12840", "l": "ATP + choline <=> ADP + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247497", "l": "ERBB3 binds neuregulins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58570", "l": "CoA + O-acetyl-15alpha-stemmadenine => 15alpha-stemmadenine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835454", "l": "DNAJC3 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35698", "l": "(3S)-versiconol acetate + NADP(+) <=> (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74715", "l": "Autophosphorylation of insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801101", "l": "RABGGTA binds RABGGTB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30711", "l": "(S)-linalool = beta-myrcene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.127", "l": "\"linalool dehydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61540", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66834", "l": "diphosphate + preasperterpenoid A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672978", "l": "RAF phosphorylates MAP2K dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14106", "l": "L-proline + NAD(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49709", "l": "nocardicin G + S-adenosyl-L-methionine => H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218804", "l": "p38 MAPK activation by VEGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76276", "l": "Na(+)(out) + uracil(out) => Na(+)(in) + uracil(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18693", "l": "a penicillin + H2O = 6-aminopenicillanate + a carboxylate", "d": [], "t": []}, {"i": "EC:3.5.1.11", "l": "\"penicillin amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005252", "l": "open rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625540", "l": "Cys-sulfenyl chloride is converted to Cys-sulfenic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33084", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67770", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53724", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63438", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) => 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725030", "l": "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202328", "l": "Translocation of PKC theta to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46823", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008897", "l": "holo-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43763", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22936", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:3.5.1.25", "l": "\"N-acetylglucosamine-6-phosphate deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375131", "l": "Basigin binds CD98 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102681", "l": "isoamylase (maltodextrin-releasing) activity", "d": ["Catalysis of the reaction: n H2O + a glycogen = n a maltodextrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32440", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30469", "l": "(+)-endo-beta-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5604929", "l": "Activated protein C binds Protein S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212614", "l": "Glutamine transport from astrocytes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62818", "l": "2 dinapinone E + 2 H2O => 4 monapinone E + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35670", "l": "a triacylglycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28275", "l": "(S)-S-adenosyl-L-methionine => (R)-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58368", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25454", "l": "diphosphate + germacrene A => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445714", "l": "Aquaporin-3 passively transports water out of cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16180", "l": "H2O + NAD(+) + retinal <=> 2 H(+) + NADH + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936676", "l": "Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38802", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877153", "l": "STARD7 binds PC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18619", "l": "ADP + CO2 + phosphoenolpyruvate => ATP + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624951", "l": "TNPO1 binds KIF17 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59525", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] => 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619355", "l": "CaMKK autophosphorylates in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41496", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65057", "l": "glycochenodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25671", "l": "sucrose + UDP-alpha-D-galactose => H(+) + loliose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20263", "l": "CO2 + CoA + olivetol => 3,5,7-trioxododecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41940", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.43", "l": "\"[amino-group carrier protein]--L-2-aminoadipate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433395", "l": "Dimerization of sSCF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36780", "l": "2-oxoglutarate + GDP-alpha-D-perosamine => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66922", "l": "(2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate => 6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.-", "l": "\"Acting on GTP; involved in cellular and subcellular movement\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69096", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine = H2O + kynurenate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53018", "l": "chloride + glutathione disulfide + H(+) + hydroquinone => chlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19869", "l": "an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.13", "l": "\"glycine N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44857", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20831", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46627", "l": "a D-5-monosubstituted hydantoin <=> a L-5-monosubstituted hydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11884", "l": "3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.18", "l": "\"cortisol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14040", "l": "4,5beta-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444516", "l": "Formation of MSH2:MSH6 Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805638", "l": "KAT6A acetylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40560", "l": "dTDP-beta-L-evernosamine + NADPH + O2 => dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62796", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B = aurasperone A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54179", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.12", "l": "\"DNA helicase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71658", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O <=> a thymidine in DNA + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251942", "l": "Hikeshi binds HSP70s:ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004902", "l": "granulocyte colony-stimulating factor receptor activity", "d": ["Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43019", "l": "an S-alkyl-L-cysteine <=> 2-aminoprop-2-enoate + an alkyl thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170001", "l": "ergothioneine transmembrane transporter activity", "d": ["Enables the transfer of ergothioneine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13794", "l": "2-methyleneglutarate => 2-methylene-3-methylsuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28153", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56568", "l": "a globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine = a globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41563", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 <=> (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802938", "l": "Inhibitors bind and inhibit highly active BRAF mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671702", "l": "AP1G2 binds HGS and CHMP2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13987", "l": "ADP + H(+) + O-phospho-L-homoserine => ATP + L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30271", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68595", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58045", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66553", "l": "L-glutaminyl-[protein] + serotonin => 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69749", "l": "(indol-3-yl)acetyl-CoA + succinate => (indol-3-yl)acetate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42973", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a cardiolipin + ethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465940", "l": "atRAL is reduced to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46502", "l": "CO2 + phosphate + succinate + uridine-5'-aldehyde => 2-oxoglutarate + O2 + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19219", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+) => 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012651", "l": "p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39207", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72697", "l": "Start codon recognition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873794", "l": "PCTP binds PC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388830", "l": "PI3K binds ICOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44399", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25557", "l": "9alpha-copalyl diphosphate => diphosphate + stemod-13(17)-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75834", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170964", "l": "FRS2 binds to active TrkA receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42779", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66158", "l": "CoA + H(+) + N-butanoyltyramine => butanoyl-CoA + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817512", "l": "UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50810", "l": "prostaglandin J2-S-(S)-glutathione => glutathione + prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56767", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 <=> 12-epi-fischerindole G + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785895", "l": "Expression of IL4, IL13-upregulated extracellular proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13827", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-alpha-D-rhamnose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692788", "l": "JUN positively regulates MAPK6 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694428", "l": "LMAN family proteins bind glycosylated cargo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43559", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016524", "l": "latrotoxin receptor activity", "d": ["Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34911", "l": "D-methionine(in) = D-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30273", "l": "2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O => 2 (3,4-dimethoxyphenyl)methanol + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.41", "l": "\"bis(5'-nucleosyl)-tetraphosphatase (symmetrical)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20421", "l": "alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:3.2.1.122", "l": "\"maltose-6'-phosphate glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55726", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354077", "l": "Integrin alphaIIb beta3 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39108", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578777", "l": "DMPK phosphorylates PLN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66598", "l": "2 dopamine => O2 + 2 tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686088", "l": "CASP3 cleaves GSDMD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874078", "l": "PTK2 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56485", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] => gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176116", "l": "Recruitment and activation of Chk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750942", "l": "USP14 deubiquitinates NLRC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33278", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4539779", "l": "Collagen type IV binds integrin alpha10beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26323", "l": "3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine => resorcinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878654", "l": "ACP6 hydrolyses MYS-LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034647", "l": "histone H3K4me/H3K4me2/H3K4me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30403", "l": "Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}, {"i": "EC:7.2.1.3", "l": "\"ascorbate ferrireductase (transmembrane)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419166", "l": "GEFs activate RhoA,B,C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55303", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30612", "l": "A + all-trans-zeta-carotene => AH2 + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26333", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": [], "t": []}, {"i": "EC:2.8.1.12", "l": "\"molybdopterin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786101", "l": "IL4 binds IL4R:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40505", "l": "N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51393", "l": "(9Z)-octadecenoyl-CoA + serotonin => CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199093", "l": "CXADR binds to AMICA1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27401", "l": "2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": [], "t": []}, {"i": "EC:5.99.1.4", "l": "\"2-hydroxychromene-2-carboxylate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77280", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693575", "l": "DNA-PKcs autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71587", "l": "(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692755", "l": "CDK1 phosphorylates MAPK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36552", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062192", "l": "L-rhamnose mutarotase activity", "d": ["Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29855", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine = D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190519", "l": "Internalization of gap junction plaques (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34892", "l": "selenite(in) => selenite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63320", "l": "a glycerophospholipid(in) + ATP + H2O = a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35261", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23056", "l": "urea = cyanamide + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.69", "l": "\"cyanamide hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69381", "l": "2-hydroxy-4-methylpentanoate + O2 => 4-methyl-2-oxopentanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22295", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63073", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130349", "l": "Generation of CLIP from lip10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700156", "l": "Active ALK dimer binds IRS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18459", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+) => D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847977", "l": "FRK phosphorylates PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317531", "l": "SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005366", "l": "myo-inositol:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11903", "l": "(2R,3S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102253", "l": "neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarobiose + H2O = 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195251", "l": "Assembly of the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41462", "l": "a 1,2-diacylglycerol + a sphingomyelin => 1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16432", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008825", "l": "cyclopropane-fatty-acyl-phospholipid synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53674", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66047", "l": "2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052868", "l": "protein-lysine lysyltransferase activity", "d": ["Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57755", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20466", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793666", "l": "MDM2 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.32", "l": "\"stem bromelain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42564", "l": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.45", "l": "\"tRNA pseudouridine(38/39) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202726", "l": "F11R dimerises (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784765", "l": "p-Y705-STAT3 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964492", "l": "DREAM complex binds the RBL1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15456", "l": "S-adenosyl-L-methionine + sarcosine <=> H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53987", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399939", "l": "Autophosphorylation of PAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73780", "l": "dimethylallyl diphosphate + preechinulin => diphosphate + tardioxopiperazine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008908", "l": "isochorismatase activity", "d": ["Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36147", "l": "acetyl-CoA + benzyl alcohol = benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41971", "l": "a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44652", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392749", "l": "Transport of L1 into endosomes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19256", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63537", "l": "bradykinin(1-8) + H2O => bradykinin(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67996", "l": "(Z)-1,2-dichloroethene + AH2 = A + chloride + chloroethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005523", "l": "tropomyosin binding", "d": ["Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43926", "l": "H(+) + NADH + pregn-5-ene-3,20-dione => NAD(+) + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24988", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374909", "l": "Catabolism of Noradrenaline (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72911", "l": "proatranorin III + S-adenosyl-L-methionine = atranorin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31677", "l": "H(+) + NADPH + perakine => NADP(+) + raucaffrinoline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419351", "l": "PAF receptor binds platelet activating factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417829", "l": "P2RY12 binds ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203611", "l": "N-myristoylation of eNOS (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25900", "l": "D-arabino-hex-3-ulose 6-phosphate = beta-D-fructose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.27", "l": "\"6-phospho-3-hexuloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47948", "l": "H2O + thiamine phosphate = phosphate + thiamine", "d": [], "t": []}, {"i": "EC:3.1.3.100", "l": "\"thiamine phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67477", "l": "dimethylallyl diphosphate + L-glutamate => diphosphate + prekainate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917693", "l": "ESCRT Disassembly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696960", "l": "USP49 deubiquitinates H2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76925", "l": "2-methylcyclopentanone + H(+) + NADPH + NH4(+) => 2-methylcyclopentanamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38859", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77301", "l": "3,7-dimethylurate + a ubiquinol => a ubiquinone + H2O + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514865", "l": "cGMP dissociates from CNG channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) = 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036348", "l": "hydantoin racemase activity", "d": ["Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952996", "l": "E2F7 forms homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57045", "l": "D-apionate + NAD(+) => 3-oxoisoapionate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59095", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose <=> [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42755", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102682", "l": "cytokinin riboside 5'-monophosphate phosphoribohydrolase activity", "d": ["Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63332", "l": "alpha-L-arabinopyanose = beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694341", "l": "Spike protein gets palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61295", "l": "(R)-pantoate + NAD(+) <=> 2-dehydropantoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018531", "l": "(S)-6-hydroxynicotine oxidase activity", "d": ["Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052683", "l": "(Z)-gamma-bisabolene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162657", "l": "Inactivation of Myt1 kinase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27867", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + alpha-D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17324", "l": "L-tryptophan + S-adenosyl-L-methionine <=> 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30595", "l": "4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.9", "l": "\"4-hydroxyphenylacetate 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173542", "l": "SMURF2 ubiquitinates SMAD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649733", "l": "mature p21 RAS binds GDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.24", "l": "\"lipopolysaccharide heptosyltransferase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445704", "l": "Calcium Binds Caldesmon (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69546", "l": "6-O-adenylylstreptidine + diphosphate => ATP + streptidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25198", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140932", "l": "5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "d": ["Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61997", "l": "L-lysyl-[protein] + lactoyl-CoA => CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030757", "l": "3-methylquercitin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41060", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30370", "l": "adenosylcob(III)alamin 5'-phosphate + H2O <=> adenosylcob(III)alamin + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-178208", "l": "SMAD7 binds to SMURF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60561", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047883", "l": "ethanolamine oxidase activity", "d": ["Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65012", "l": "decanoyl-AMP + holo-[ACP] = AMP + decanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63912", "l": "6-azauridine + ATP = 6-azauridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14498", "l": "A + pyridoxine => AH2 + isopyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10954", "l": "(E)-sinapoyltartronate + CoA => (E)-sinapoyl-CoA + hydroxymalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848414", "l": "Activated PTK6 binds CDKN1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051118", "l": "glucan endo-1,3-alpha-glucosidase activity", "d": ["Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851933", "l": "MET phosphorylates GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425861", "l": "Activation of Protein Kinase C novel isoforms (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75937", "l": "6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+) => ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021050", "l": "HSBP1 oligomer binds ESRs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61407", "l": "ATP + N-(D-ribulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201611", "l": "Caspase-mediated cleavage of Rock-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50182", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114683", "l": "Phosphorylation of Platelet Sec-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25212", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine <=> acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692867", "l": "HRH3 binds pitosilant (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48426", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20878", "l": "(E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein] => (R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.125", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870466", "l": "RGGT:CHM binds RABs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050609", "l": "phosphonate dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + phosphonate = 2 H+ + NADH + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76632", "l": "Ca(2+)(in) + n H(+)(out) => Ca(2+)(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26159", "l": "D-mannose + NADP(+) <=> D-glucosone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610627", "l": "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56063", "l": "H(+) + hexadecanoate + hnu <=> CO2 + pentadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52891", "l": "N-phenylhydroxylamine + NADP(+) <=> H(+) + NADPH + nitrosobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110156", "l": "UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35528", "l": "H(+) + N-ethylmaleimide + NADH => N-ethylsuccinimide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43851", "l": "[thioredoxin]-dithiol + arsenate + H(+) <=> [thioredoxin]-disulfide + arsenite + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22752", "l": "A + H2O + uracil = AH2 + barbiturate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624798", "l": "LBR binds KPNB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177690", "l": "Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987007", "l": "p-STAT1 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19829", "l": "a primary alcohol + O2 = an aldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.13", "l": "\"alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22350", "l": "imidazol-4-one + NH4(+) => 4-aminoimidazole + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75522", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 <=> (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047849", "l": "dextransucrase activity", "d": ["Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54381", "l": "(2E,6E)-farnesyl diphosphate + H2O => 5-hydroxy-alpha-gurjunene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48304", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68575", "l": "L-tyrosine(in) <=> L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68374", "l": "2-oxosuccinamate + L-alanine => L-asparagine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65020", "l": "L-ornithine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707683", "l": "PGRMC2 binds Hemes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23467", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867613", "l": "PICALM binds R-SNAREs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029680", "l": "Caspase-7 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62534", "l": "dihydrodigitoxin + 2 Fe(III)-[cytochrome c] => digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75683", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 = (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45178", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050350", "l": "trihydroxystilbene synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168459", "l": "Lyn activates ERK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27881", "l": "2',3'-cyclophospho-UMP + H2O <=> 3'-UMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72996", "l": "L-fucose(out) + 2 Na(+)(out) => L-fucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769401", "l": "DKK and KRM bind LRP5/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16427", "l": "formate + 2 H(+) + NADH => formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69568", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008657", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37274", "l": "ATP + H2O + L-alanyl-L-glutamine(out) <=> ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183051", "l": "CBL ubiquitinates Sprouty (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679028", "l": "JAK3 binds JAK3 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25289", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8980691", "l": "RHOA GEFs activate RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25626", "l": "H2O + histamine + O2 => H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029471", "l": "Hydrolysis of PC to PA by PLD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28829", "l": "L-ornithine(in) + putrescine(out) => L-ornithine(out) + putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65990", "l": "calciol => previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54109", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + guaia-4,6-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008993", "l": "rhamnulokinase activity", "d": ["Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69520", "l": "H2O + N-acetyl-D-galactosamino-1,5-lactone = H(+) + N-acetyl-D-galactosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482770", "l": "Release of platelet secretory granule components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658253", "l": "RAS:GTP binds PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798044", "l": "BTG2 binds CCR4-NOT complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37805", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14493", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] = ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": [], "t": []}, {"i": "EC:3.2.2.24", "l": "\"ADP-ribosyl-[dinitrogen reductase] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14373", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63638", "l": "a medium-chain fatty acyl-[ACP] + AMP + H(+) => a medium-chain fatty acyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047460", "l": "L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity", "d": ["Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H2O = 2-oxopent-4-enoate + chloride + H+ + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72672", "l": "The 60S subunit joins the translation initiation complex  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160050", "l": "xanthine binding", "d": ["Binding to xanthine, a purine base."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5622129", "l": "FABP5 binds atRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73694", "l": "3'-AMP(out) + phosphate(in) <=> 3'-AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59166", "l": "AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52655", "l": "lanosterol + S-adenosyl-L-methionine <=> eburicol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381091", "l": "IRE1 dimer autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004949", "l": "cannabinoid receptor activity", "d": ["Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050499", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H."], "t": []}, {"i": "EC:1.20.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19541", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.41", "l": "\"glutamate-5-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75763", "l": "(9E,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33587", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}, {"i": "EC:2.3.1.201", "l": "\"UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601910", "l": "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193537", "l": "5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44826", "l": "a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665659", "l": "RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448678", "l": "CTSG cleaves CASP1(1-404) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39966", "l": "2-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31688", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9702818", "l": "CALCR binds erenumab (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692408", "l": "NPR2 binds NPPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047789", "l": "creatininase activity", "d": ["Catalysis of the reaction: creatinine + H2O = creatine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71184", "l": "L-kynurenine(out) + L-tryptophan(in) => L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41544", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.306", "l": "\"8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)-tetracenomycin-C 3'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55881", "l": "apo-[aequorin]--coelenterazine + O2 => [aequorin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72697", "l": "Start codon recognition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54788", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53494", "l": "5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) => 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67753", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21501", "l": "UDP-alpha-D-glucose => H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213246", "l": "Disassociation of CLIP from MHC II (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40808", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19945", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.201", "l": "\"alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863463", "l": "STON2 binds SYT proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198599", "l": "AKT phosphorylates MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46297", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622831", "l": "Substrate:LAMP2a binds HSP90 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73085", "l": "S-adenosyl-L-homocysteine + velutin => chrysoeriol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76522", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] <=> (R)-lipoate + L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430347", "l": "MigFilin associates with Filamin and F-actin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211951", "l": "CYP1B1 4-hydroxylates EST17b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77142", "l": "1D-myo-inositol 2,3-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061686", "l": "hercynylcysteine sulfoxide synthase activity", "d": ["Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 = hercynylcysteine sulfoxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004185", "l": "serine-type carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38119", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64442", "l": "glycylglycyl-L-proline(in) + H(+)(in) => glycylglycyl-L-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51152", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 = 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": [], "t": []}, {"i": "EC:1.8.3.7", "l": "\"formylglycine-generating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65165", "l": "benzoyl-CoA + hexan-3-ol => CoA + hexan-3-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57932", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38566", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O <=> 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41224", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35889", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72988", "l": "myo-inositol(out) + 2 Na(+)(out) => myo-inositol(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042007", "l": "interleukin-18 binding", "d": ["Binding to interleukin-18."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156930", "l": "GTP-binding activates eEF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73328", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA => cimicifugate J + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869683", "l": "oxPL binds LBP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55515", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390930", "l": "5-HT2 receptor can bind serotonin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47911", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O <=> 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450550", "l": "PKCalpha phosphorylates HuR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53685", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45408", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH = dodecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65790", "l": "3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705926", "l": "AR binds AR agonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49008", "l": "aurachin C + H(+) + NADPH + O2 = aurachin C epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14865", "l": "S-adenosyl-L-methionine + tyramine = H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.27", "l": "\"tyramine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937134", "l": "miR-27a binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10486", "l": "(E)-ferulate + glycine => H2O + N-feruloylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35073", "l": "4-methylphenol(out) => 4-methylphenol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218806", "l": "FYN autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37639", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156699", "l": "Inactivation of Wee1 kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70789", "l": "H(+)(out) + L-citrulline(out) + L-ornithine(in) => H(+)(in) + L-citrulline(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014296", "l": "RAC2 GEFs activate RAC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989774", "l": "Expression of AGT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71156", "l": "(E)-caffeoylpyruvate + H2O => (E)-caffeate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938853", "l": "CDK6 binds RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61582", "l": "(5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => (3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61856", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 = betaenone C + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727297", "l": "mRNA7 is translated to protein 7a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678920", "l": "TLR processing at low pH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66178", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out) => ATP + H2O + taurochenodeoxycholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43180", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.311", "l": "\"25S rRNA (cytosine(2278)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26344", "l": "L-selenocysteine + S-methyl-L-methionine <=> H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.40", "l": "\"pyruvate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76515", "l": "H2O + orobanchol = 5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0070853", "l": "myosin VI binding", "d": ["Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66227", "l": "asc-C9-CoA + O2 <=> asc-DeltaC9-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20809", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-7-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202709", "l": "JAM2 dimerises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29731", "l": "beta-maltose(in) = beta-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73264", "l": "genkwanin + S-adenosyl-L-methionine => apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418858", "l": "RhoGTPase GEF's recruited to DCC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247922", "l": "GGCT transforms gGluCys to OPRO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23677", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70129", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49684", "l": "H(+) + NADH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.220", "l": "\"resorcinol 4-hydroxylase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045157", "l": "electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity", "d": ["Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49497", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637765", "l": "Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42986", "l": "diphosphate + pimara-8(14),15-diene => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10940", "l": "(2E)-geranyl diphosphate = (4R)-limonene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.20", "l": "\"(R)-limonene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67904", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685607", "l": "Sialic acid binds SIGLEC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61112", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24070", "l": "H2O + hexano-6-lactone + NADP(+) => cyclohexanone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28815", "l": "4-hydroxybenzoate(in) + H(+)(out) = 4-hydroxybenzoate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052725", "l": "inositol-1,3,4-trisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49616", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) = 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.98", "l": "\"2-hydroxy-2-methylpropanal dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005000", "l": "vasopressin receptor activity", "d": ["Combining with vasopressin to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60067", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26112", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631885", "l": "PRDX1 overoxidizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390846", "l": "D2D3,4 bind to DA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30220", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62075", "l": "D-galactose 6-phosphate + NADP(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050166", "l": "pantoate 4-dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + H+ + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31675", "l": "NADP(+) + raucaffrinoline = H(+) + NADPH + perakine", "d": [], "t": []}, {"i": "EC:1.1.1.317", "l": "\"perakine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49782", "l": "CoA + H(+) + N-docosanoylglycine => docosanoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623806", "l": "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134953", "l": "DHX36 or DHX9 binds MyD88 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36923", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25874", "l": "H2O + pyridine N-oxide => H2O2 + pyridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16088", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392530", "l": "p-S400-Cot phosphorylates NIK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60034", "l": "8-oxo-GDP + H(+) + phosphate => 8-oxo-GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944216", "l": "Association of procollagen type XV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53061", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848939", "l": "PTK6 binds KHDRBS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77197", "l": "(2E)-decenoyl-CoA => (3Z)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57281", "l": "a guanosine in RNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140475", "l": "spindle pole body anchor activity", "d": ["The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34710", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835385", "l": "DUS2 binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617881", "l": "HOXB4 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863973", "l": "Fusion of ERC and phagosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936563", "l": "ISGylation of DDX58 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341294", "l": "Superoxide reduces cytochrome c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961920", "l": "E2F1 binds the CDK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693243", "l": "RHOD translocates to the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64918", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48391", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44900", "l": "D-galactono-1,4-lactone + H2O = D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43364", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose = beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30318", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35608", "l": "acetoin + NADP(+) => diacetyl + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10996", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.91", "l": "\"isobutyraldoxime O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009037", "l": "tyrosine-based site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52533", "l": "adenosine + GTP => AMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214351", "l": "PLK1 phosphorylates GORASP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114419", "l": "Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31406", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) <=> all-trans-4,4'-diaponeurosporene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29947", "l": "H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-rhamnopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30956", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone => 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39706", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (13Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41716", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75731", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) = 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30367", "l": "adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24618", "l": "estrone + H(+) + NADPH => 17beta-estradiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19401", "l": "methanol + NAD(+) = formaldehyde + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.244", "l": "\"methanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169406", "l": "ISGylation of host proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29819", "l": "ATP + H2O + L-isoleucine(out) = ADP + H(+) + L-isoleucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000825", "l": "inositol tetrakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45092", "l": "H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66160", "l": "hexanoyl-CoA + tyramine = CoA + H(+) + N-hexanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106625", "l": "Duplex siRNA is loaded into Argonaute (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27677", "l": "ATP + dADP <=> ADP + dATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166214", "l": "FA anion flip-flops to the opposite surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75166", "l": "NAD(+) + UTP <=> H(+) + NADP(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709317", "l": "CO binds to free ferrohemoglobin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622386", "l": "LEF1 binds the promoter of the CEBPA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15386", "l": "L-asparagine => 3-cyano-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481007", "l": "Exocytosis of platelet alpha granule contents (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34213", "l": "ecgonone methyl ester + H(+) + NADPH => ecgonine methyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29380", "l": "dGMP + H2O => 2'-deoxyguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49292", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.205", "l": "\"protein-N(pi)-phosphohistidine--D-cellobiose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940100", "l": "CDK1 phosphorylates VCPIP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106615", "l": "Removal of siRNA passenger strand (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31439", "l": "(2E,6E)-farnesyl diphosphate = alpha-longipinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.80", "l": "\"alpha-longipinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322429", "l": "XIAP monoubiquinates TLE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373717", "l": "DCC interacts with DIP13alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52347", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042356", "l": "GDP-4-dehydro-D-rhamnose reductase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25741", "l": "H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18316", "l": "(R)-mandelonitrile <=> benzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72109", "l": "Na(+)(in) + O-acyl-(R)-carnitine(in) => Na(+)(out) + O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197958", "l": "FPGS-2 transforms THF to THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34375", "l": "4-guanidinobutanamide + H2O = 4-guanidinobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29905", "l": "ADP + D-ribose(in) + H(+) + phosphate => ATP + D-ribose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12711", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28743", "l": "nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371527", "l": "HSF1 trimer translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68541", "l": "(2Z,6Z)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66646", "l": "diphosphate + trichobrasilenol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372697", "l": "Crk binding to p130cas (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177479", "l": "Axonal transport of NGF:Trk complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16690", "l": "D-glucose 6-phosphate + H2O => D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097682", "l": "intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity", "d": ["Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76289", "l": "Na(+)(in) + thymine(in) => Na(+)(out) + thymine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55083", "l": "ADP-alpha-D-glucose + D-fructose <=> ADP + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70971", "l": "citrate <=> isocitrate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58557", "l": "15alpha-stemmadenine intermediate II + H2O => (16S)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202709", "l": "JAM2 dimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36340", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986083", "l": "USP33 deubiquitinates ROBO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198714", "l": "ERK5 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21532", "l": "ATP + glutathione + glutathionylspermidine = ADP + H(+) + phosphate + trypanothione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917839", "l": "apo-Transferrin dissociates from the receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75157", "l": "diphosphate + verrucosan-2beta-ol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34629", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62775", "l": "N-acetyl-D-phenylalanine <=> N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63698", "l": "H(+) + SN-38 O-beta-D-glucuronide + UDP => SN-38 + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23051", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate <=> (R)-2-hydroxyglutarate + acetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41356", "l": "bacteriochlorophyll a + 3 NADP(+) = geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.111", "l": "\"geranylgeranyl-bacteriochlorophyllide a reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68658", "l": "7beta-hydroxycholesterol + NADP(+) => 7-oxocholesterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73048", "l": "guanidinoacetate(in) => guanidinoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683606", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618834", "l": "Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787820", "l": "IL34 dimer binds CSF1R (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21436", "l": "[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.11.20", "l": "\"[elongation factor 2] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73752", "l": "(R)-adrenaline(in) + 2 H(+)(out) => (R)-adrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221061", "l": "TDG excises 5-carboxylcytosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13626", "l": "A + H2O + N(6)-dimethylallyladenine => 3-methyl-2-butenal + adenine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211219", "l": "Translocation of caspase-3 to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55936", "l": "all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934688", "l": "RUNX1:CBFB binds the LIFR gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61532", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21852", "l": "(R)-10-hydroxyoctadecanoate = (9Z)-octadecenoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.53", "l": "\"oleate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831107", "l": "Nascent SH localizes to Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848873", "l": "PTK6 phosphorylates ARAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210290", "l": "Interaction of PECAM-1 and SHIP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58238", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => L-tyrosyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38326", "l": "2 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12578", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170986", "l": "Ral-GDS binds to Ras-GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13102", "l": "4-imidazolone-5-propanoate => H2O + trans-urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005143", "l": "interleukin-12 receptor binding", "d": ["Binding to an interleukin-12 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48958", "l": "[thyroglobulin]-3-iodo-L-tyrosine + 2 H2O => [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112430", "l": "Formation of P-TEFb complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15791", "l": "H(+) + L-xylono-1,4-lactone + NADPH => L-xylose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733969", "l": "Bile salts dissociate from FABP6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252001", "l": "ATP1B4 binds SNW1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047036", "l": "codeinone reductase (NADPH) activity", "d": ["Catalysis of the reaction: codeine + NADP+ = codeinone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12101", "l": "1,5-anhydro-D-fructose => H2O + microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22476", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61347", "l": "H2O + L-serine + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69876", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047235", "l": "sucrose 6F-alpha-galactotransferase activity", "d": ["Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042299", "l": "lupeol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34302", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate <=> 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098613", "l": "methaneselenol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide."], "t": []}, {"i": "REACT:R-HSA-2408541", "l": "MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60834", "l": "a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate => a 5'-end triphospho-guanosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43714", "l": "diphosphate + dodecanoyl-AMP => ATP + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41855", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] <=> 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55159", "l": "a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54617", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 => 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60760", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone = CoA + jasmolin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592362", "l": "Activation of proMMP7 by MMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097158", "l": "pre-mRNA intronic pyrimidine-rich binding", "d": ["Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32529", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine => N,N'-diacetylchitobiose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56819", "l": "a pyrimidine ribonucleoside + H2O <=> a pyrimidine nucleobase + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050507", "l": "indoxyl-UDPG glucosyltransferase activity", "d": ["Catalysis of the reaction: indoxyl + UDP-D-glucose = H+ + indican + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66056", "l": "indole-3-pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874718", "l": "TTPA binds alpha-TOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25270", "l": "(R)-noradrenaline + S-adenosyl-L-methionine => (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39403", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62974", "l": "3 CO2 + 4 CoA + orsellinate => acetyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62302", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2059926", "l": "NPHP4 protein binds LATS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033416", "l": "UGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGG codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72430", "l": "chloride(in) + K(+)(in) <=> chloride(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17627", "l": "H(+) + L-lysine + NADPH + pyruvate => D-lysopine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237119", "l": "Acireductone is oxidized to MOB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0090490", "l": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)", "d": ["Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.245", "l": "\"assimilatory dimethylsulfide S-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508292", "l": "SYK binds IL2RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12760", "l": "dihydrozeatin + NADP(+) <=> H(+) + NADPH + zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031521", "l": "NR1H2,3 binds the APOC2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850818", "l": "SPINK9 binds KLK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56311", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45204", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol = H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": [], "t": []}, {"i": "EC:2.1.1.90", "l": "\"methanol--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54483", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73350", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine <=> beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49153", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853908", "l": "VENTX stimulates CSF1R (M-CSF-R) expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62043", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate <=> N-octanoylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67238", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA => mycophenolyl-CoA + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247847", "l": "WLS is endocytosed to the early endosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060182", "l": "apelin receptor activity", "d": ["Combining with the peptide apelin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612509", "l": "SGK phosphorylates SRF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031864", "l": "EP1 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP1 subtype prostaglandin E2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995330", "l": "COX10 transforms heme to heme O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52485", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65565", "l": "(9Z)-octadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41033", "l": "1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871226", "l": "RET binds GFRA1,GFRA2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328037", "l": "Fibrillin-1 binds integrins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190682", "l": "Connexin synthesis (generic) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004848", "l": "ureidoglycolate hydrolase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372697", "l": "Crk binding to p130cas (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9690494", "l": "RHOB translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33552", "l": "an N-acylsphinganine + H2O => a fatty acid + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11243", "l": "ATP + thiamine diphosphate <=> ADP + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57395", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine <=> 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58672", "l": "D-glucuronate = aldehydo-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14039", "l": "cortisone + H(+) + NADPH => 4,5beta-dihydrocortisone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199046", "l": "Ligands bind L-selectin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977959", "l": "ERBB4 forms heterodimers with EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40683", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol = 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27895", "l": "3'-CMP + H2O => cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60241", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32279", "l": "allantoate + 2 H(+) + 2 H2O = (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788346", "l": "Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55444", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32910", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70668", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65336", "l": "chrodrimanin T + H(+) + NADPH + O2 = chrodrimanin A + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202692", "l": "PIP3 binds to RhoA and activates it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71223", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) = chloride(in) + 2 Na(+)(in) + taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52126", "l": "(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140343", "l": "phosphatidylserine transfer activity", "d": ["Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51526", "l": "magnoflorine + S-adenosyl-L-homocysteine => (S)-corytuberine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77054", "l": "3,5-dimethylcyclohexanamine + H2O + NADP(+) <=> 3,5-dimethylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42400", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + lactose 6-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.207", "l": "\"protein-N(pi)-phosphohistidine--lactose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36597", "l": "NADPH + sulfur => hydrogen sulfide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944232", "l": "Association of procollagen type XII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578965", "l": "TNRC6A binds AGO2:miRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626034", "l": "EEF1A1 dissociates from p-GFAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332236", "l": "CBL neddylates TGFBR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031686", "l": "A1 adenosine receptor binding", "d": ["Binding to an A1 adenosine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63376", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43908", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = D-galactose + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070284", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity", "d": ["Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19467", "l": "H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42679", "l": "L-cysteine + L-histidine + O2 <=> H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67474", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine => H2O + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692539", "l": "HRH1 binds HRH1 inverse agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45552", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52509", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61892", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665871", "l": "ADRM1 binds 26S proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10819", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside <=> L-fucose + methyl beta-D-galactoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592362", "l": "Activation of proMMP7 by MMP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33233", "l": "heme d cis-diol => H2O2 + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48136", "l": "a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44177", "l": "a 2,3-diacyl-sn-glycerol + H2O => a 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50703", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26394", "l": "all-trans-zeaxanthin + 2 O2 => 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030487", "l": "inositol-4,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432516", "l": "CLK and CYC bind to form a heterodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030378", "l": "serine racemase activity", "d": ["Catalysis of the synthesis of free D-serine from L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75332", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) => chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62272", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878654", "l": "ACP6 hydrolyses MYS-LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42829", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047572", "l": "3-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + H2O = D-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59057", "l": "2 methanethiol + NAD(+) => dimethyl disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016689", "l": "manganese peroxidase activity", "d": ["Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59252", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16747", "l": "2,3-epoxyphylloquinone + A + H2O => AH2 + O2 + phylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11961", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64655", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.129", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60613", "l": "1-octanoyl-sn-glycero-3-phosphocholine => 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24237", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine => 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004122", "l": "cystathionine beta-synthase activity", "d": ["Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34684", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O => alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047354", "l": "sphingosine cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + sphingosine = CMP + H+ + sphingosyl-phosphocholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668605", "l": "RAC2:GTP binds NOX2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381091", "l": "IRE1 dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636564", "l": "SapM binds RAB7A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28506", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102534", "l": "apigenin-7,4'-dimethyl ether 6-hydroxylase activity", "d": ["Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ = ladanein + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58881", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17089", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43915", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433456", "l": "Recruitment of STATs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692755", "l": "CDK1 phosphorylates MAPK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254291", "l": "ERBB4s80 binds STAT5A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22764", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.36", "l": "\"phosphoinositide 5-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483219", "l": "PC is exchanged with PI by PITPNB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213244", "l": "Loading of antigenic peptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34627", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42212", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67663", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002953", "l": "5'-deoxynucleotidase activity", "d": ["Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63425", "l": "(2S)-2-phospholactate + GTP + H(+) => (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17609", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:1.1.98.7", "l": "\"serine-type anaerobic sulfatase-maturating enzyme\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50505", "l": "acetyl-CoA + N-terminal L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16835", "l": "glutathione disulfide + 2 H2O => 2 glutathione + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11172", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": [], "t": []}, {"i": "EC:2.1.1.13", "l": "\"methionine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20770", "l": "CO2 + phosphonoacetaldehyde => 3-phosphonopyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727349", "l": "XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785087", "l": "FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71639", "l": "K(+)(in) + Na(+)(in) = K(+)(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52552", "l": "3-dehydro-L-erythronate + ATP = 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432067", "l": "Aquaporin-4 passively transports water out of cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52589", "l": "choloyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72054", "l": "butanoate(out) + estrone 3-sulfate(in) <=> butanoate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417908", "l": "P2RY1 binds ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050249", "l": "Renilla-luciferin sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H+ + luciferyl sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63523", "l": "2-isopropylphenol + H(+) + NADH + O2 <=> 3-isopropylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76995", "l": "H(+) + NADP(+) + 2 reduced [4Fe-4S]-[ferredoxin] = NADPH + 2 oxidized [4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632652", "l": "Hh-Npp binds CDON and PTCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691621", "l": "C5 binds C5 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16286", "l": "D-octopine + H2O + NAD(+) => H(+) + L-arginine + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28104", "l": "D-mannose + GDP + H(+) => GDP-alpha-D-mannose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16310", "l": "H2O + taurochenodeoxycholate => chenodeoxycholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0140996", "l": "histone H3 kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54205", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63625", "l": "hexadecanoyl-AMP + holo-[ACP] => AMP + H(+) + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55112", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849435", "l": "PTPN1 dephosphorylates PTK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77102", "l": "5-hydroxymethyl-dUMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40673", "l": "NH4(+) + pyruvate => 2-iminopropanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.154", "l": "\"ureidoglycolate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651467", "l": "SERPING1 variant does not bind kallikrein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166753", "l": "Conversion of C4 into C4a and C4b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34180", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide => D-glucuronate + H(+) + mycophenolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43065", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate => holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620788", "l": "FOXO1,FOXO3,FOXO4 binds RBL2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67113", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71386", "l": "L-asparagine(in) + Na(+)(in) <=> L-asparagine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29131", "l": "menaquinol-8 + nitrate = H2O + menaquinone-8 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71794", "l": "(R)-lactate(in) + H(+)(in) <=> (R)-lactate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35339", "l": "3-hydroxyicosanoyl-CoA + NADP(+) = 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180573", "l": "Degradation of ubiquitinated CD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965450", "l": "DAAM1 recruits PFN1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179293", "l": "UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20101", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:6.2.1.19", "l": "\"long-chain-fatty-acid--protein ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34372", "l": "H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72616", "l": "H(+)(out) + L-alanyl-L-valine(out) => H(+)(in) + L-alanyl-L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40678", "l": "L-threonine <=> 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39978", "l": "2-iminobutanoate + H2O <=> 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12631", "l": "(6S)-6-hydroxyhyoscyamine + CO2 + succinate => 2-oxoglutarate + L-hyoscyamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822734", "l": "Caplacizumab binds VWF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74511", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702613", "l": "ponatinib-resistant FLT3 mutants don't bind ponatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77612", "l": "2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) => 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749215", "l": "MCM8 binds CDC6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39942", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174255", "l": "Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45362", "l": "(11Z)-eicosenoate + sphinganine => H2O + N-(11Z-eicosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16510", "l": "H(+) + oxalate => CO2 + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21598", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => L-serine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832938", "l": "Expression of OTX2 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66148", "l": "2-phenylethylamine + acetyl-CoA = CoA + H(+) + N-(2-phenylethyl)acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706293", "l": "Active FLT3 binds to CBL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404144", "l": "Parenchymal atROL translocates to HSCs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42316", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.11", "l": "\"2-oxoacid oxidoreductase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814831", "l": "TBC1D20 binds RAB1:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15227", "l": "diphosphate + dTDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + dTTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61651", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate <=> AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170978", "l": "p-FRS2:CRKL binds C3G (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71999", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682011", "l": "LC3 binds ATG7 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008976", "l": "polyphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36962", "l": "D-ribono-1,4-lactone + H(+) + NADH <=> D-ribose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.117", "l": "\"6-aminohexanoate-oligomer endohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50627", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O <=> a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697064", "l": "lprG binds to LAM,LM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624949", "l": "Assembly of the anterograde IFT train (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47674", "l": "2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45087", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14964", "l": "H2O + S-formylglutathione <=> formate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692315", "l": "OX40L binds OX40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033454", "l": "GCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209156", "l": "MYD88 binds to TUB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42701", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O => 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14916", "l": "AMP + thymidine <=> adenosine + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209960", "l": "Diiodinated tyrosine can be deiodinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65129", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420977", "l": "Ca permeable AMPA receptor ligand binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903136", "l": "cuprous ion binding", "d": ["Binding to a cuprous ion, copper(1+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40286", "l": "(R)-carnitine + hexadecanedioyl-CoA <=> CoA + O-hexadecanedioyl-L-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59904", "l": "H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901680", "l": "sulfur-containing amino acid secondary active transmembrane transporter activity", "d": ["Enables the transfer of sulfur-containing amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694563", "l": "ABHD10 hydrolyses MPAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50851", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034200", "l": "D,D-heptose 1,7-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70971", "l": "D-dopa + H2O + O2 = 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11929", "l": "hydroxylamine + NH4(+) => H(+) + H2O + hydrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47328", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13327", "l": "3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.27", "l": "\"uracil-DNA glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140740", "l": "ADP-riboxanase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4(+) + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102891", "l": "2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone = H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68943", "l": "Na(+)(in) + tellurite(in) <=> Na(+)(out) + tellurite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874078", "l": "PTK2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836404", "l": "p-PKR dimer phosphorylates MAPT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62819", "l": "4 monapinone E + O2 <=> 2 dinapinone E + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034871", "l": "1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709360", "l": "H2O2 reduces MetHb (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64048", "l": "(13Z)-docosenoyl-CoA + sphinganine = CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140793", "l": "histone H2AXY142 phosphatase activity", "d": ["Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61909", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol => 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102149", "l": "farnesylcysteine lyase activity", "d": ["Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O = (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47735", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31451", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25261", "l": "2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41709", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51232", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990931", "l": "mRNA N6-methyladenosine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.5", "l": "\"tetraether lipid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22449", "l": "ATP + pseudouridine => ADP + H(+) + psi-UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693250", "l": "RHOD binds effectors at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202726", "l": "F11R dimerises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46800", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:7.2.1.2", "l": "\"ferredoxin--NAD(+) oxidoreductase (Na(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24244", "l": "NADP(+) + pseudotropine = H(+) + NADPH + tropinone", "d": [], "t": []}, {"i": "EC:1.1.1.236", "l": "\"tropinone reductase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76060", "l": "RNA Polymerase III Promoter Opening at Type 1 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28707", "l": "Cd(2+)(in) = Cd(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698844", "l": "MLKL binds HSP90:CDC37 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27506", "l": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.84", "l": "\"cocaine esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13187", "l": "hydroxymethylbilane + 4 NH4(+) => H2O + 4 porphobilinogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030732", "l": "methionine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190141", "l": "ALAD binds to Pb2+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56466", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13761", "l": "L-methionine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": [], "t": []}, {"i": "EC:2.1.1.12", "l": "\"methionine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75194", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46737", "l": "H2O + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951486", "l": "CD46 binds C4b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11963", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204779", "l": "Interaction of Tie2 with Ang1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65438", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate => a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77329", "l": "5-amino-2-oxopentanoate + L-alanine => L-ornithine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42067", "l": "ATP + GTP <=> 2',3'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35531", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 = albonoursin + 2 H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.13", "l": "\"albonoursin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937034", "l": "IRAK1 phosphorylates Pellino (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019145", "l": "aminobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20776", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose", "d": [], "t": []}, {"i": "EC:2.4.1.67", "l": "\"galactinol--raffinose galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666430", "l": "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71039", "l": "L-methionine(in) + L-phenylalanine(out) = L-methionine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849857", "l": "KLK5 cleaves and activates CELA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28269", "l": "(2E,6E)-farnesyl diphosphate <=> (S)-beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73155", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) = adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51632", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199456", "l": "PTEN dephosphorylates PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863011", "l": "p25-bound CDK5 phosphorylates CDC25C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50361", "l": "(R)-mandelonitrile + O2 => benzoyl cyanide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66045", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33127", "l": "H2O + salicin-6-phosphate = beta-D-glucose 6-phosphate + salicyl alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47376", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156699", "l": "Inactivation of Wee1 kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212352", "l": "Formation of ARC coactivator complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76230", "l": "(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate <=> (indol-3-yl)acetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731931", "l": "EDNRA binds selective ERAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13330", "l": "A + a 3-oxosteroid => a 3-oxo-Delta(1)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840564", "l": "OMA1 hydrolyzes YME1L1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635804", "l": "ATF4 and phospho-ATF2 bind the DDIT3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65407", "l": "butan-1-ol + hexanoyl-CoA <=> butyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57245", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72767", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH = 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38046", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57160", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114352", "l": "Sequestration of tBID by BCL-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692794", "l": "p-S215 FOXO1 positively regulates RAG gene expression  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29705", "l": "L-valine(out) => L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38956", "l": "an N-acylsphing-4-enine 1-phosphate(in) => an N-acylsphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9707856", "l": "PGRMC2:Hemes dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390930", "l": "5-HT2 receptor can bind serotonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38211", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034610", "l": "oligodeoxyribonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72033", "l": "(E)-sinapaldehyde + H2O2 => (E)-sinapyl alcohol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199404", "l": "CD40L binds CD40 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42915", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007901", "l": "IL1F10 binds IL1RL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602458", "l": "Activation of proMMP10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693644", "l": "HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296326", "l": "HCAR1 binds LACT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112037", "l": "Inactivation of PLC beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75855", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080031", "l": "methyl salicylate esterase activity", "d": ["Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047693", "l": "ATP diphosphatase activity", "d": ["Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48863", "l": "18-HEPE + O2 <=> (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35996", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68809", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O => alpha-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019166", "l": "trans-2-enoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33227", "l": "(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374899", "l": "Release of noradrenaline  at the synapse (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27997", "l": "H2O + xanthosine <=> D-ribose + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71259", "l": "2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27596", "l": "all-trans-nonaprenyl diphosphate + 5 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14610", "l": "D-sorbitol + NADP(+) => H(+) + keto-L-sorbose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25066", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40396", "l": "1,2-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14143", "l": "adenosine 5'-phosphosulfate + 2 glutathione => AMP + glutathione disulfide + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51380", "l": "(9Z)-octadecenoyl-CoA + dopamine = CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037040", "l": "SRC,FYN phosphorylate NTRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045480", "l": "galactose oxidase activity", "d": ["Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052894", "l": "norspermine:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26381", "l": "4-hydroxybutanoate + NADP(+) = H(+) + NADPH + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:1.1.1.n11", "l": "\"succinic semialdehyde reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66574", "l": "2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-naphthol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018554", "l": "1,2-dihydroxynaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52624", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.60", "l": "\"glutamate--[amino group carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390909", "l": "HRH2 binds hist (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175993", "l": "HNMT transfers CH3 group from AdoMet to Hist (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033463", "l": "GGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047491", "l": "poly(alpha-L-guluronate) lyase activity", "d": ["Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36797", "l": "a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a ribonucleoside 5'-triphosphate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23449", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP => CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67366", "l": "L-serine + L-threonine => H2O + L-threonyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54191", "l": "H2O + N-acetyl-L-phenylalanine <=> acetate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48176", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58021", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => eupatolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209143", "l": "Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0002094", "l": "polyprenyltransferase activity", "d": ["Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140537", "l": "transcription regulator activator activity", "d": ["A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58352", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28356", "l": "(2E)-decenoyl-CoA + FADH2 => decanoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828720", "l": "SH mRNA is translated into protein SHt (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48983", "l": "3,4-dichlorocatechol + O2 <=> (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186780", "l": "Degradation of Ub-SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849085", "l": "ARHGAP35 binds RHOA:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.18", "l": "\"glutathione transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67026", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.775903698273282", "identifiers": [{"i": "GO:0140030", "l": "modification-dependent protein binding", "d": ["Binding to a protein upon post-translation modification of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648017", "l": "EML4 binds to microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785762", "l": "IL13RA1 binds TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67347", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13579", "l": "a long chain fatty alcohol + a long-chain fatty acid + H(+) => a wax ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.20", "l": "\"succinyl-CoA--D-citramalate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66805", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814096", "l": "ARL1:GTP binds SCOC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23307", "l": "atropine + H2O <=> H(+) + tropate + tropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731081", "l": "Syndecan-1 binds Integrin alphaVBeta5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32770", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730848", "l": "Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751013", "l": "Inactive G alpha (s) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-555065", "l": "Formation of clathrin coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-622310", "l": "Activated NOD1 oligomerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32670", "l": "coenzyme M + methanethiol <=> H(+) + hydrogen sulfide + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5600598", "l": "Defective CYP11B2 does not oxidise 11DCORST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033776", "l": "phenylacetone monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13875", "l": "abieta-7,13-diene + diphosphate => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627350", "l": "SMAC (DIABLO) binds XIAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681375", "l": "KIT binds ripretinib (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48234", "l": "CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde => acetyl-CoA + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63195", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 <=> glycine betaine + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008732", "l": "L-allo-threonine aldolase activity", "d": ["Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19670", "l": "GTP + H2O => GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791158", "l": "Expression of CXXC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52506", "l": "(9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13669", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.51", "l": "\"3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11062", "l": "AMP + diphosphate + L-isoleucyl-tRNA(Ile) => ATP + L-isoleucine + tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32104", "l": "2 S-adenosyl-L-methionine + trans-resveratrol => 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23813", "l": "(+)-neomenthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12368", "l": "2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.4", "l": "\"dehydrogluconate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444523", "l": "Formation of MSH1:PMS2 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36554", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781953", "l": "YOD1 binds VCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016532", "l": "superoxide dismutase copper chaperone activity", "d": ["A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66394", "l": "ADP + H(+) + phosphate + prostaglandin E1(out) => ATP + H2O + prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29686", "l": "alpha-maltohexaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37013", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432129", "l": "FGR binds and phosphorylates LRP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.3", "l": "\"thiamine phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13307", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + UDP => (E)-sinapate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18463", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690461", "l": "FKBP1A binds tacrolimus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69166", "l": "2 H(+) + N-(2-carboxyethyl)putrescine + NADH => H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683393", "l": "nsp15 binds nsp8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57328", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327733", "l": "FN1 binds Collagen types I-V, VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018832", "l": "halohydrin hydrogen-halide-lyase B activity", "d": ["Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73749", "l": "(R)-noradrenaline(out) + 2 H(+)(in) => (R)-noradrenaline(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42951", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244415", "l": "botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021596", "l": "Membrane estrogen receptors bind SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63274", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64621", "l": "(E)-sinapyl alcohol + acetyl-CoA => (E)-sinapoyl actetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0033677", "l": "DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592234", "l": "Expression of GABPA (NRF2 alpha subunit) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32822", "l": "chromate(in) <=> chromate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46843", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.73", "l": "\"albendazole monooxygenase (sufoxide-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22965", "l": "H(+) + L-ornithine => CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2562526", "l": "PLK1 phosphorylates OPTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66955", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36994", "l": "phosphate + UMP <=> alpha-D-ribose 1,5-bisphosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102137", "l": "7-oxateasterone synthase activity", "d": ["Catalysis of the reaction: H+ + teasterone + NADPH + O2 = 7-oxateasterone + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51771", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate <=> 4-prenylphlormethylbutanophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56369", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015481", "l": "maltose transporting porin activity", "d": ["Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67662", "l": "a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018653", "l": "3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65424", "l": "AMP(in) + NAD(+)(out) = AMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11684", "l": "methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21881", "l": "2 H(+) + O2 + oxalate => 2 CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060230", "l": "lipoprotein lipase activator activity", "d": ["Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35827", "l": "H2O + N(1)-aminopropylagmatine = spermidine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.24", "l": "\"N(1)-aminopropylagmatine ureohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18775", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112271", "l": "The receptor:G-protein complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40908", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48287", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> a globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168285", "l": "Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015111", "l": "Factor Xa inhibitors binds Xa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76107", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 = (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396029", "l": "Latent TGF-beta-3 binds integrins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28645", "l": "alpha-zingiberene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39676", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850997", "l": "TRIM27 binds PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44294", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14082", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250220", "l": "Homodimerization of ERBB4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75974", "l": "NADP(+) + neomorphine <=> H(+) + NADPH + neomorphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36808", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA => 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25728", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46675", "l": "aldosterone + H(+) + NADPH <=> 5beta-dihydroaldosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174171", "l": "Association of Cyclin A with the APC/C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396399", "l": "Fibrillins bind BMPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35797", "l": "H(+) + kanamycin A + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10487", "l": "H2O + N-feruloylglycine <=> (E)-ferulate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27464", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77601", "l": "3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol) => 2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672176", "l": "STAT binds to the mutant PDGFRA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173318", "l": "C5a anaphylatoxin binds C5a receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65726", "l": "CO2 + H(+) + pentanal + succinate + sulfate => 2-oxoglutarate + O2 + pentyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800794", "l": "PIDD1 associates with CRADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015207", "l": "adenine transmembrane transporter activity", "d": ["Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52851", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine <=> 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016153", "l": "urocanate hydratase activity", "d": ["Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379864", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61390", "l": "ADP + biotin(out) + H(+) + phosphate => ATP + biotin(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685542", "l": "Viral release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755303", "l": "26S proteasome degrades HIFalpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029451", "l": "Activation of RAC1 by VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26498", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561072", "l": "OCT3 mediates renal uptake of organic cations (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626699", "l": "MARK4 binds ODF2 in the centriole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64354", "l": "2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29366", "l": "dCMP + H2O <=> 2'-deoxycytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22678", "l": "7(1)-hydroxychlorophyllide a + H2O + NADP(+) => chlorophyllide a + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74732", "l": "rhamnetin + S-adenosyl-L-methionine => 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61803", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine <=> AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73963", "l": "(2E,6E)-farnesyl diphosphate = aristolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74356", "l": "a cytidine in mRNA + H(+) + H2O => a uridine in mRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76808", "l": "(S)-isoleucinol + H2O + NAD(+) => (3S)-1-hydroxy-3-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22553", "l": "3'-phosphoadenylyl sulfate + an alcohol => adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613497", "l": "Unwinding DNA for the nascent transcript (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65679", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11947", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874197", "l": "CREB3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264848", "l": "apoA-I binds to CUBN:AMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53527", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444691", "l": "Prokineticin receptors bind prokineticin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22541", "l": "5'-dehydroadenosine + H2O + O2 => 9-riburonosyladenine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67889", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine => 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64505", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine => 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32313", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031844", "l": "type 4 neuropeptide Y receptor binding", "d": ["Binding to a type 4 neuropeptide Y receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850961", "l": "PREX2 binds PTEN and inhibits it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28682", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34649", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31521", "l": "3-methyl-2-butenal + 4'-apo-beta-carotenal => O2 + torulene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682598", "l": "ATM phosphorylates HERC2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57379", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75662", "l": "(11Z,14Z)-eicosadienoate + O2 <=> 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15037", "l": "putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.53", "l": "\"putrescine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23918", "l": "CO2 + UDP-alpha-D-xylose => H(+) + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551555", "l": "RYK binds WNT5A and VANGL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38500", "l": "a triacyl-sn-glycerol + H2O => a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35402", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine <=> beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65619", "l": "A + cholest-4-en-3-one + H2O <=> 25-hydroxycholest-4-en-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76946", "l": "3-aminohexane + H2O + NADP(+) <=> H(+) + hexan-3-one + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47446", "l": "(5Z)-tetradecenoyl-CoA + acetyl-CoA => 3-oxo-(7Z-hexadecenoyl)-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004952", "l": "dopamine neurotransmitter receptor activity", "d": ["Combining with the neurotransmitter dopamine to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13555", "l": "ADP + alpha-D-galactose 1-phosphate + H(+) => alpha-D-galactose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53391", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28252", "l": "acetoacetyl-CoA + CO2 + CoA => acetyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57450", "l": "AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+) => ATP + D-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20748", "l": "2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.1", "l": "\"deacetoxycephalosporin-C synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814088", "l": "SYS1 binds AcM-ARFRP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20162", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose => myo-inositol + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358790", "l": "RNF41 ubiquitinates ERBB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30977", "l": "5 AH2 + all-trans-3,4-didehydrolycopene => 15-cis-phytoene + 5 A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28193", "l": "2'-deoxyadenosine + H(+) + H2O <=> 2'-deoxyinosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26082", "l": "(2E,6E)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421835", "l": "trans-Golgi Network Vesicle Scission (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63009", "l": "(6Z)-octadecenamide + H2O => (6Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38483", "l": "a 2,3-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26479", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) => a 2-demethylmenaquinol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35602", "l": "NADP(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31685", "l": "(-)-solanapyrone A => prosolanapyrone III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71878", "l": "2 Na(+)(out) + taurocholate(out) <=> 2 Na(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59163", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548830", "l": "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76466", "l": "CYP4A11 12-hydroxylates DDCX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374701", "l": "Phosphorylation of DCC by Fyn (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48219", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008463", "l": "formylmethionine deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-methionine + H2O = L-methionine + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51020", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] = an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.8", "l": "\"alcohol dehydrogenase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72691", "l": "Formation of the 43S pre-initiation complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14919", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54829", "l": "dimethylamine + H(+) + NADPH + O2 => formaldehyde + H2O + methylamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47557", "l": "H2O + taurodeoxycholate => deoxycholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48252", "l": "a ganglioside GD2 + UDP-alpha-D-galactose = a ganglioside GD1b + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080030", "l": "methyl indole-3-acetate esterase activity", "d": ["Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71576", "l": "5-phosphomethyl-dUMP in DNA + putrescine => 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51974", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76456", "l": "O-atom dealkylation of dextromethorphan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34046", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine <=> 5''-phosphoribostamycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32988", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14226", "l": "6-hydroxyhexanoate + NAD(+) => 6-oxohexanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31331", "l": "ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.75", "l": "\"molybdopterin adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62667", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine <=> deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70573", "l": "argininosuccinate <=> fumarate + arginine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64672", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol = butyl 2-(methylsulfanyl)acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659764", "l": "Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417825", "l": "P2Y11 receptor can bind to ATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624211", "l": "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849094", "l": "ARHGAP35 binds RASA1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533965", "l": "NID1 degradation by MMP14, MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66718", "l": "(2S)-3-sulfolactaldehyde + D-fructose 6-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210932", "l": "ANTXR2-bound pagA(197-794) forms oligomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0002161", "l": "aminoacyl-tRNA editing activity", "d": ["The hydrolysis of an incorrectly aminoacylated tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23525", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol => an alkyl cinnamate + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757688", "l": "SERPINA6 binds PREDN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435244", "l": "PECAM1 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57233", "l": "GDP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48766", "l": "3-acetyl-3-devinylchlorophyllide a + H(+) + NADH => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75778", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O <=> (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793949", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11833", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2214324", "l": "Collagen type VII dimerization (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097604", "l": "temperature-gated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665709", "l": "ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73255", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine = (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35575", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51504", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.360", "l": "\"2-hydroxyflavanone C-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044610", "l": "FMN transmembrane transporter activity", "d": ["Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694433", "l": "MIA2 binds PREB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63356", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12862", "l": "guanosine + H(+) + H2O => NH4(+) + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53776", "l": "3-sulfanylpropanoate + O2 = 3-sulfinopropanoate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.91", "l": "\"3-mercaptopropionate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001092", "l": "TFIIA-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30304", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.128", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29834", "l": "Ni(2+)(in) <=> Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50068", "l": "ATP + glycoursodeoxycholate(in) + H2O = ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16918", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 => 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170846", "l": "TGFBR2 recruits TGFBR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24979", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72144", "l": "AH2 + GTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49995", "l": "H(+) + NADH + O2 + propane <=> H2O + NAD(+) + propan-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203712", "l": "eNOS associates with Caveolin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836606", "l": "SPHK1 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676254", "l": "Formation of the MLL3 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749320", "l": "CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75204", "l": "alpha,alpha-trehalose(out) + ATP + H2O => ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32736", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671702", "l": "AP1G2 binds HGS and CHMP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849878", "l": "PSD-95 binds NMDA receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15032", "l": "D-mannitol + NAD(+) <=> D-mannose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23292", "l": "ATP + L-lombricine = ADP + H(+) + N-phospho-L-lombricine", "d": [], "t": []}, {"i": "EC:2.7.3.5", "l": "\"lombricine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15158", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15621", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.122", "l": "\"N-acetylgalactosaminide beta-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39842", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31519", "l": "O2 + torulene = 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": [], "t": []}, {"i": "EC:1.13.11.59", "l": "\"torulene dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399711", "l": "Activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640167", "l": "RRAGA,B exchanges GDP for GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645428", "l": "ALPK1 binds ADP-heptose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13887", "l": "CO2 + stipitatate => H2O + stipitatonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351871", "l": "Caspase-mediated cleavage of Z0-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53655", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76413", "l": "2',3'-cGAMP(in) + n H(+)(in) => 2',3'-cGAMP(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54411", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47615", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24704", "l": "CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose => NAD(+) + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783670", "l": "CRLF1 binds CLCF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965446", "l": "WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450533", "l": "PKCdelta phosphorylates HuR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804276", "l": "ATM phosphorylates TTC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.184720489211337", "identifiers": [{"i": "GO:0016817", "l": "hydrolase activity, acting on acid anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride."], "t": []}, {"i": "EC:3.6.-.-", "l": "\"Acting on acid anhydrides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380782", "l": "STAT binds to the active receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54078", "l": "diphosphate + stellata-2,6,19-triene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21847", "l": "L-glutamine + phenylacetyl-CoA <=> CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-212614", "l": "Glutamine transport from astrocytes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174916", "l": "Formation of N-glucuronides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047322", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity", "d": ["Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047220", "l": "galactosylxylosylprotein 3-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49421", "l": "ATP + valienone => ADP + H(+) + valienone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451418", "l": "Pellino ubiquitinates IRAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41575", "l": "lipoxin A4 + NAD(+) <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668395", "l": "CHMP7 binds CC2D1B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51038", "l": "2 H2O + indole-3-pyruvate imine dimer => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388808", "l": "CD28 homodimer binds B7-2 monomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029454", "l": "Autophosphorylation of PAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429845", "l": "5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39006", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63911", "l": "ATP + H2O + pravastatin(in) <=> ADP + H(+) + phosphate + pravastatin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11152", "l": "5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.241", "l": "\"5-pyridoxate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112385", "l": "Addition of nucleotides leads to transcript elongation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034889", "l": "endosulfan hemisulfate sulfatase activity", "d": ["Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24874", "l": "H2O + O-phospho-D-serine => D-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.78", "l": "\"granzyme A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32258", "l": "meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168400", "l": "iE-DAP elicits a NOD1 response (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11752", "l": "acetylsalicylate + H2O = acetate + H(+) + salicylate", "d": [], "t": []}, {"i": "EC:3.1.1.55", "l": "\"acetylsalicylate deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034236", "l": "protein kinase A catalytic subunit binding", "d": ["Binding to one or both of the catalytic subunits of protein kinase A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696323", "l": "CNRs bind CNR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167511", "l": "HLCS biotinylates ACACB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619376", "l": "CAMK1 binds calmodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193668", "l": "p75NTR and RHOA-GDI interact (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694442", "l": "CNIH2,3 bind GRIA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.353", "l": "\"demethylluteothin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004551", "l": "dinucleotide phosphatase activity", "d": ["Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047199", "l": "phosphatidylcholine-dolichol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58825", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47514", "l": "isocholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56782", "l": "(+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66495", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37792", "l": "aclacinomycin A + O2 => aclacinomycin Y + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.26", "l": "\"toluene methyl-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042561", "l": "alpha-amyrin synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835443", "l": "STAT1,STAT3 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47531", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isocholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45074", "l": "(9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001681", "l": "sialate O-acetylesterase activity", "d": ["Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047681", "l": "aryl-alcohol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23622", "l": "AMP + deoxyamidinoproclavaminate + diphosphate + H(+) => ATP + N(2)-(2-carboxyethyl)-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655839", "l": "Expression of Phosphomevalonate Kinase (PMVK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611721", "l": "β1-agonists bind ADRB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12999", "l": "2-O-[(E)-feruloyl]-D-galactarate + CoA => (E)-feruloyl-CoA + galactarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13306", "l": "(E)-sinapate + UDP-alpha-D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19425", "l": "H(+) + imidazole-4-acetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.5", "l": "\"imidazoleacetate 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38727", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52470", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72970", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) <=> 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18496", "l": "benzoyl-CoA + glycine <=> CoA + H(+) + N-benzoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73206", "l": "D-glucose(out) + H(+)(in) <=> D-glucose(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641134", "l": "SMURF2 binds AXIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10350", "l": "ADP + H(+) + L-glutamate + phosphate => 5-oxo-L-proline + ATP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17518", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate => a long-chain fatty acid + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814764", "l": "Plasma membrane resorption (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34467", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + valerena-4,7(11)-diene", "d": [], "t": []}, {"i": "EC:4.2.3.139", "l": "\"valerena-4,7(11)-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610723", "l": "GLI proteins bind SUFU (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102420", "l": "sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity", "d": ["Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796042", "l": "NFE2L2 dependent ABCF2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30022", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + lipid A-core", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70097", "l": "peniphenone D => (R)-5-methyl-tetronate + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11525", "l": "5beta-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54122", "l": "coelenterazine h dioxetanone => coelenterazine h + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28725", "l": "(S)-allantoin(out) + H(+)(out) => (S)-allantoin(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757451", "l": "ASA-,ST translocate from cytosol to ER lumen of hepatocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49858", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047430", "l": "oligosaccharide-diphosphodolichol diphosphatase activity", "d": ["Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27811", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate => (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396392", "l": "NOTCH1 PEST domain mutants bind HES1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14674", "l": "a polar amino acid(out) + ATP + H2O => a polar amino acid(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32061", "l": "(R)-glycerate + D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001858", "l": "complement component iC3b receptor activity", "d": ["Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56789", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin => cob(II)alamin-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47238", "l": "(2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein] => eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868118", "l": "MAPK12 phosphorylates PTPN3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912734", "l": "CBL:CRKL binds RAPGEF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950415", "l": "Expression of heterogeneous nuclear ribonucleoprotein F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11730", "l": "cyclopentanone + H(+) + NADH => cyclopentanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917693", "l": "ESCRT Disassembly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102946", "l": "soyasapogenol E UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E = UDP + a soyasapogenol E monoglucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044653", "l": "dextrin alpha-glucosidase activity", "d": ["Catalysis of the reaction: dextrin + H2O = alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045135", "l": "poly(beta-D-mannuronate) lyase activity", "d": ["Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32925", "l": "glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483219", "l": "PC is exchanged with PI by PITPNB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73984", "l": "(2E,6E)-farnesyl diphosphate => (-)-beta-barbatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38747", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45996", "l": "a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.5.1", "l": "\"D-amino acid dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26397", "l": "all-trans-zeaxanthin + 2 O2 = 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}, {"i": "EC:1.13.11.84", "l": "\"crocetin dialdehyde synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418850", "l": "Activation of Cdc42 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660828", "l": "ADORA2B:Ade-Rib binds heterometric G-protein Gs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26090", "l": "(4S)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77433", "l": "a ganglioside GT1c + H(+) + UDP => a ganglioside GT2 + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351948", "l": "Mitochondrial recruitment of Drp1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14938", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70596", "l": "GOT2 dimer deaminates L-Asp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57051", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088130", "l": "PLK1 binds FOXM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803892", "l": "SFN dimer binds BAX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372529", "l": "Release of acetylcholine at the synapse (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388503", "l": "Oxytocin receptor bind oxytocin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76345", "l": "(2S)-2-isopropylmalate(out) + sulfate(in) => (2S)-2-isopropylmalate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12919", "l": "D-glucose + strictosidine aglycone => 3alpha(S)-strictosidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42510", "l": "5-acetamidopentanoate + CO2 + H(+) + NADH => 6-acetamido-2-oxohexanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38040", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48512", "l": "ATP + H2O + phosphinate(out) = ADP + H(+) + phosphate + phosphinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73023", "l": "pregnenolone sulfate(out) = pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2059926", "l": "NPHP4 protein binds LATS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112703", "l": "PTPN11 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034541", "l": "dimethylarsinite methyltransferase activity", "d": ["Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660694", "l": "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382061", "l": "Extracellular processing of novel PDGFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10001", "l": "H2O + pentanamide => NH4(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018495", "l": "2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71353", "l": "androsterone 3alpha-sulfate(in) + 2 Na(+)(in) => androsterone 3alpha-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34143", "l": "cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63928", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20316", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP <=> 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252072", "l": "AZGP1 binds PIP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67647", "l": "ATP + dZDP <=> ADP + dZTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399712", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772430", "l": "CTNNBIP1 binds beta-catenin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045509", "l": "interleukin-27 receptor activity", "d": ["Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869694", "l": "oxPL binds CD14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53245", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16253", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol", "d": [], "t": []}, {"i": "EC:1.3.1.49", "l": "\"cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10190", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+) => acetoacetyl-CoA + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950342", "l": "EBI3:CANX binds IL27 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22485", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => GMP + GTP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75238", "l": "TRAIL binds TRAIL receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75068", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73569", "l": "ITP(in) + UTP(out) => ITP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17099", "l": "enol-phenylpyruvate => 3-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30718", "l": "(2E)-geraniol <=> (S)-linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0016722", "l": "oxidoreductase activity, acting on metal ions", "d": ["Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45527", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21462", "l": "2 benzaldehyde => benzoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.31", "l": "\"mycolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690152", "l": "USP5 cleaves polyubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851979", "l": "BTNL9 binds immune cell surfaces (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65936", "l": "beta-D-mannose = beta-D-glucose", "d": [], "t": []}, {"i": "EC:5.1.3.44", "l": "\"mannose 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14630", "l": "ATP + N-acetyl-L-glutamate => ADP + N-acetyl-L-glutamyl 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16987", "l": "H(+) + maleylacetate + NADPH => 3-oxoadipate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019828", "l": "aspartic-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71849", "l": "LDH tetramer reduces PYR to LACT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65878", "l": "1-hydroxy-5alpha-androstan-3,17-dione => 5alpha-androst-1-ene-3,17-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399928", "l": "Recruitment of Rnd1 to Plexin A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13195", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52584", "l": "chenodeoxycholoyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904678", "l": "alpha-aminoacyl-tRNA binding", "d": ["Binding to an alpha-aminoacyl-tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139909", "l": "Translocation of BMF to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001596", "l": "angiotensin type I receptor activity", "d": ["An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41271", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437999", "l": "Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56537", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33088", "l": "cyclic dehypoxanthinylfutalosinate => 1,4-dihydroxy-6-naphthoate + chemical entity", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213200", "l": "Release of endostatin-like peptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391377", "l": "Luteinizing hormone receptor can bind LH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28617", "l": "(1Z,2S)-2-methylbutanal oxime <=> (2S)-2-methylbutanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25897", "l": "H(+) + malonate => acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29362", "l": "H2O + UMP <=> phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018685", "l": "alkane 1-monooxygenase activity", "d": ["Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061752", "l": "telomeric repeat-containing RNA binding", "d": ["Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28979", "l": "H(+)(out) + nitrite(in) = H(+)(in) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798528", "l": "S100A8:S100A9 binds Mn2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14499", "l": "AH2 + isopyridoxal => A + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73357", "l": "carcinine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56900", "l": "a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = a globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624800", "l": "CDK1 phosphorylates LBR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64780", "l": "S-benzyl-L-cysteine = 2-aminoprop-2-enoate + benzylthiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56534", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74640", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) => AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67544", "l": "(9Z)-tetradecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202726", "l": "F11R dimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68044", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51179", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41195", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809010", "l": "COPI vesicle uncoating (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936058", "l": "miR-675 binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673346", "l": "Unknown kinase phosphorylates p-DVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58074", "l": "a jasmonate + NADP(+) => a 4,5-didehydrojasmonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24261", "l": "(3E)-2-oxohex-3-enedioate + H(+) => 2-oxopent-4-enoate + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65699", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22878", "l": "(R)-mandelate + NH4(+) => (R)-mandelamide + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033808", "l": "6'-deoxychalcone synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018515", "l": "pimeloyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759513", "l": "CDH11 canonical mRNA is translated into CDH11 canonical protein isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12724", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + S-methyl-5'-thioadenosine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14329", "l": "2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22312", "l": "5-(methylsulfanyl)-D-ribose + ATP = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.100", "l": "\"S-methyl-5-thioribose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49639", "l": "H2O + methylglyoxal + O2 <=> H(+) + H2O2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17859", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate => O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19705", "l": "CoA + hexadecanal + NAD(+) = H(+) + hexadecanoyl-CoA + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.42", "l": "\"hexadecanal dehydrogenase (acylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37364", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858475", "l": "ppDVL recruits RAC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48008", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 = 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.209", "l": "\"salicyloyl-CoA 5-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64107", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] <=> 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27871", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74558", "l": "(S)-malate(out) <=> (S)-malate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018800", "l": "5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46658", "l": "5beta-androstane-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354066", "l": "Translocation of PTK2 to Focal complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377644", "l": "Release of CSK from SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76907", "l": "(1S)-2-methyl-cyclohexylamine + H2O + NADP(+) = 2-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71982", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72439", "l": "(E)-ferulate + ATP + H(+) = (E)-feruloyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24294", "l": "CoA + H(+) + N-acetyl-L-glutamate => acetyl-CoA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033853", "l": "aspartate-prephenate aminotransferase activity", "d": ["Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033509", "l": "USP9X binds Ub:PEX5L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77062", "l": "3-methylcyclopentanamine + H2O + NADP(+) <=> 3-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44150", "l": "D-beta-lysine => L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60714", "l": "(+)-artemisinic aldehyde + H(+) + NADH => (+)-artemisinic alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51770", "l": "4-prenylphlormethylbutanophenone + diphosphate => 2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15891", "l": "L-glutamate + NH4(+) => H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76650", "l": "(3S)-3-hydroxyadipyl-CoA <=> (E)-2,3-didehydroadipoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62747", "l": "H2O + mevastatin <=> (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57859", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 <=> (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28817", "l": "4-hydroxybenzoate(out) + H(+)(in) => 4-hydroxybenzoate(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004637", "l": "phosphoribosylamine-glycine ligase activity", "d": ["Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047654", "l": "alliin lyase activity", "d": ["Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016844", "l": "strictosidine synthase activity", "d": ["Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634834", "l": "ACHEIs bind ACHE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57501", "l": "3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32833", "l": "an R-cob(III)alamin(out) => an R-cob(III)alamin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014449", "l": "RHOG binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112282", "l": "CAMK4 enters the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093329", "l": "EFNBs bind SDCBP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26293", "l": "(1'S,5'S)-averufin + NADPH + O2 = 1'-hydroxyversicolorone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66927", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA <=> [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759356", "l": "NFE2L2-dependent GSTA3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9658253", "l": "RAS:GTP binds PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66226", "l": "asc-DeltaC9-CoA + H2O2 => asc-C9-CoA + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65718", "l": "an aldehyde + CO2 + H(+) + succinate + sulfate => 2-oxoglutarate + a primary linear alkyl sulfate ester + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23503", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) <=> 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57040", "l": "aldehydo-D-apiose = D-apiofuranose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982775", "l": "Growth hormone receptor dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71414", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71210", "l": "iodide(out) + 2 Na(+)(out) <=> iodide(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031852", "l": "mu-type opioid receptor binding", "d": ["Binding to a mu-type opioid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9615348", "l": "AGT(34-41) binds to AGTR2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69012", "l": "5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099534", "l": "calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30234", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine <=> (2E,6E)-farnesal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38651", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49412", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose = alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.341", "l": "\"alpha-1,2-colitosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67541", "l": "(9Z)-hexadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874685", "l": "CBL binds MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66425", "l": "ATP + H2O + leukotriene B4(in) => ADP + H(+) + leukotriene B4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159259", "l": "MMAA:MUT binds AdoCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12543", "l": "ATP + L-alanine + tRNA(Ala) <=> AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62299", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) <=> (+)-malbrancheamide + 2 FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191072", "l": "Synthesis of Cx43 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70132", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48607", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15852", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015607", "l": "ABC-type fatty-acyl-CoA transporter activity", "d": ["Catalysis of the reaction ATP + H2O + fatty acyl CoA(Side 1) = ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56517", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 => 2 CO2 + 4 H2O + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162657", "l": "Inactivation of Myt1 kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10409", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA => 3-oxopristanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38045", "l": "(4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40734", "l": "(20S)-ginsenoside Rg3 + 2 H2O <=> (20S)-protopanaxadiol + 2 D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49721", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NAD(+) + violacein", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22433", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62808", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46541", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636658", "l": "esxA binds PGK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41078", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357472", "l": "PAK1-3 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022456", "l": "MECP2 binds 5mC-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18768", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45722", "l": "N-hexadecanoylsphing-4-enine(out) => N-hexadecanoylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176298", "l": "Activation of claspin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29279", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide = H2O + menaquinone-8 + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33455", "l": "4alpha-carboxyzymosterol + NADP(+) = CO2 + NADPH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52408", "l": "4-phospho-D-erythronate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.409", "l": "\"4-phospho-D-erythronate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13644", "l": "H(+) + methane + NADPH + O2 <=> H2O + methanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42901", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38271", "l": "(3S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.153", "l": "\"3-methylfumaryl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74388", "l": "formamide(out) => formamide(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15057", "l": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25339", "l": "H(+) + urea => isocyanate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40077", "l": "futalosine + NH4(+) => 6-amino-6-deoxyfutalosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20168", "l": "H2O + N(5)-acyl-L-ornithine ester <=> an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72424", "l": "(E)-4-coumaroyl-AMP + CoA => (E)-4-coumaroyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39343", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA = (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65495", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21148", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.156", "l": "\"indolylacetyl-myo-inositol galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76517", "l": "5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings => H2O + orobanchol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15309", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.5", "l": "\"phycocyanobilin:ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46136", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 = 2 H2O + NADP(+) + pyrrolnitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76064", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) => 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102902", "l": "isopimaradienal hydroxylase activity", "d": ["Catalysis of the reaction: isopimaradienal + NADPH + O2 = isopimaric acid + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69156", "l": "spermine dialdehyde = acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210439", "l": "glutamate uptake by astrocytes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33211", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) = 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10875", "l": "H2O + N-acyl-L-aspartate <=> a carboxylate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21359", "l": "L-arabinitol + NAD(+) <=> H(+) + L-ribulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9670673", "l": "FIX is secreted (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217255", "l": "FMO1:FAD N-oxidises TAM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20468", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168848", "l": "tBID binds to inactive BAK protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58497", "l": "choline + H(+) + NADH + O2 => glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707594", "l": "Hemes bind LY96 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56257", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928641", "l": "PAK binds RAC and bPIX (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420121", "l": "SFKs phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047266", "l": "poly(ribitol-phosphate) beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341072", "l": "SUMOylation of RARA with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022141", "l": "Prolysyl oxidase activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10039", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 <=> H2O2 + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420265", "l": "AMY1-3 bind IAPP(34-70) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847537", "l": "RAB43:GTP binds USP8NL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25650", "l": "(2R,5R)-isopulegone + NADP(+) => (6R)-isopiperitenone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36115", "l": "gibberellin A3 + S-adenosyl-L-methionine = O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31009", "l": "beta-amyrin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12534", "l": "coenzyme M-coenzyme B heterodisulfide + methane => coenzyme B + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634228", "l": "TRAF1 is cleaved by caspases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74392", "l": "methylamine(out) => methylamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47988", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.389", "l": "\"2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23556", "l": "D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4(+)", "d": [], "t": []}, {"i": "EC:2.3.2.14", "l": "\"D-alanine gamma-glutamyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11588", "l": "A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one", "d": [], "t": []}, {"i": "EC:1.3.99.16", "l": "\"isoquinoline 1-oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16839", "l": "a carboxylate + AMP + 2 H(+) => 5'-acylphosphoadenosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090556", "l": "phosphatidylserine floppase activity", "d": ["Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}, {"i": "RHEA:38567", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57010", "l": "2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+) => 5,5'-dehydrodivanillate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203973", "l": "Vesicle budding (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.242", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52434", "l": "2 NH4(+) + pyruvate => (R)-2,3-diaminopropanoate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.2", "l": "\"small monomeric GTPase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.75", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592362", "l": "Activation of proMMP7 by MMP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33352", "l": "hexacosanoyl-CoA + sphinganine => CoA + H(+) + N-hexacosanoylsphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50423", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] <=> H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.34", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29681", "l": "formate(out) => formate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59447", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A <=> 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19313", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.8", "l": "\"alpha-N-acetylneuraminate alpha-2,8-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40120", "l": "H2O + tetradecanoyl-CoA => CoA + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56896", "l": "a carboxylate + ATP + H(+) = an acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.34", "l": "\"lipoprotein lipase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69134", "l": "5-aminopentanal + H2O2 + NH4(+) => cadaverine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65364", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66707", "l": "H2O + mycophenolyl-CoA <=> CoA + H(+) + mycophenolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43443", "l": "hexadecanoate + sphinganine <=> H2O + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38048", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905131", "l": "carcinine transmembrane transporter activity", "d": ["Enables the transfer of carcinine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134962", "l": "DHX36 binds DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254251", "l": "ERBB4s80 binds YAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45257", "l": "hexadecanoate(out) => hexadecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20977", "l": "a primary nitroalkane + H2O + O2 => an aldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61142", "l": "CO2 + H(+) + H2O + myricetin + succinate => (2R,3R)-dihydromyricetin + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67173", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] => formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545196", "l": "FN1 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34757", "l": "D-glucose + N-acyl-15-methylhexadecasphing-4-enine => H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72142", "l": "estrone 3-sulfate(in) + H(+)(out) <=> estrone 3-sulfate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202233", "l": "Inactivation of Lck by Csk (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442832", "l": "PAK phosphorylates cortactin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196026", "l": "Dab2 is recruited to the junctional plaques (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46592", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000298", "l": "endopolyphosphatase activity", "d": ["Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202241", "l": "Recruitment of SLP-76 to Gads (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24955", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48210", "l": "(2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14296", "l": "D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448678", "l": "CTSG cleaves CASP1(1-404) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444661", "l": "HCAR2 binds HCAR2 ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102238", "l": "geraniol kinase activity (ATP-dependent) activity", "d": ["Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37735", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43200", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.226", "l": "\"23S rRNA (cytidine(1920)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73198", "l": "malonate(in) + sulfate(out) <=> malonate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72404", "l": "2-oxoglutarate(out) + urate(in) => 2-oxoglutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73205", "l": "D-glucose(in) + H(+)(out) => D-glucose(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8960973", "l": "RLBP1:11cRAL dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64945", "l": "dCTP + 2 H2O => dCMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674397", "l": "Imatinib-resistant PDGFR mutants don't bind imatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645535", "l": "ALPK1 phosphorylates TIFA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41991", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71195", "l": "H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450466", "l": "AUF1:mRNA complex is destroyed (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451895", "l": "IL2RG binds JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28759", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.325", "l": "\"TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650447", "l": "SERPING1 variant is not secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162096", "l": "carbovir diphosphate + ATP => carbovir triphosphate + ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34551", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine = ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24734", "l": "2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374919", "l": "Noradrenaline clearance from the synaptic cleft (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24686", "l": "H2O + N-formylmethanofuran = formate + methanofuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64519", "l": "2-hydroxyethane-1-sulfonate + NAD(+) <=> H(+) + NADH + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3159253", "l": "MMAB adenosylates cob(I)alamin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65246", "l": "(2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-hesperetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22338", "l": "L-methionine + N,N-dimethylglycine => glycine betaine + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944457", "l": "MAF1 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61385", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-919404", "l": "Phosphorylated STAT5 is released (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59710", "l": "D-maltotrionate + H(+) => D-maltotriono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38788", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15153", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.194", "l": "\"4-hydroxybenzoate 4-O-beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17825", "l": "ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936599", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690785", "l": "BAP1 binds Ub-HCFC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42325", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) => 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962039", "l": "TK1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11851", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine <=> [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15319", "l": "2-deoxy-D-glucose + an alcohol => a 2-deoxy-alpha-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42881", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine => H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625510", "l": "FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21658", "l": "CDP-3,6-dideoxy-alpha-D-mannose => CDP-alpha-D-paratose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871226", "l": "RET binds GFRA1,GFRA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30753", "l": "AMP + diphosphate + hexadecanoyl-CoA => ATP + CoA + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014449", "l": "RHOG binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202443", "l": "Oligomerization of CARMA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75458", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592371", "l": "Initial activation of proMMP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25404", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate = (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49742", "l": "CO2 + deoxyviolacein + 2 H2O + NADP(+) => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75973", "l": "H(+) + NADPH + neomorphinone => NADP(+) + neomorphine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38681", "l": "ADP + H(+) + phosphate + sphinganine(out) => ATP + H2O + sphinganine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43114", "l": "H(+) + NADH + phenylglyoxylate => (R)-mandelate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983427", "l": "Expression of peptide bound class I MHC on cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30560", "l": "GTP + H2O => guanosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51865", "l": "(2E)-geranyl diphosphate + esculetin => 8-geranylesculetin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38221", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13096", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51983", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254290", "l": "CSN2 gene expression is stimulated by ERBB4s80:STAT5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004905", "l": "type I interferon receptor activity", "d": ["Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015209", "l": "cytosine transmembrane transporter activity", "d": ["Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050594", "l": "tabersonine 16-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + tabersonine = 16-hydroxytabersonine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49569", "l": "2-glutathionyl-2-methylbut-3-en-1-ol => (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54771", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9627369", "l": "SEPT4 binds XIAP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52758", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37350", "l": "(R)-lactate + ATP + D-alanine <=> ADP + D-alanyl-(R)-lactate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426566", "l": "Interaction of DAP12 and CLM7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55329", "l": "9-cis-retinol + hexadecanoyl-CoA => 9-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72588", "l": "(E)-sinapate + ATP + CoA => (E)-sinapoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605797", "l": "SMPD1 hydrolyzes SPHM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11299", "l": "2,5-dioxopentanoate + H2O + NADP(+) <=> 2-oxoglutarate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55380", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) = a 3-oxo bile acid CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67591", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607058", "l": "Activated protein C:PROCR binds F2R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047932", "l": "glucosamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047053", "l": "(S)-cheilanthifoline synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 = (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74923", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] = a (2E)-enoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39915", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20827", "l": "adenosine + ATP <=> ADP + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68900", "l": "4-methoxybenzoate + ATP + H(+) + NADPH = 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25760", "l": "ent-copalyl diphosphate => diphosphate + ent-isokaurene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665767", "l": "Activated FMNL3 binds G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0016662", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome."], "t": []}, {"i": "EC:1.7.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55257", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27405", "l": "a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2", "d": [], "t": []}, {"i": "EC:1.2.5.1", "l": "\"pyruvate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74740", "l": "Binding of SHC1 to insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16051", "l": "adenosylcob(III)alamin + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682011", "l": "LC3 binds ATG7 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23230", "l": "H2O + N(6)-hydroxy-L-lysine + NADP(+) => L-lysine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864433", "l": "TFAP2A,TFAP2C homodimers stimulate CGA gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72234", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) <=> chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031722", "l": "hemoglobin beta binding", "d": ["Binding to a hemoglobin beta chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28049", "l": "phosphate + propanoyl-CoA <=> CoA + propanoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202472", "l": "Translocation of TRAF6 to CBM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61324", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63927", "l": "ATP + N(4)-acetylcytidine <=> ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34855", "l": "2 H2O + iminodiacetonitrile = N-(cyanomethyl)glycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44113", "l": "hexadecanoyl-CoA + nonan-1-ol => CoA + nonyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73075", "l": "luteolin + S-adenosyl-L-methionine = H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77000", "l": "H(+) + NAD(+) + reduced [4Fe-4S]/[3Fe-4S]-[ferredoxin] => NADH + oxidized [4Fe-4S]/[3Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65145", "l": "2-oxoglutarate + berkeleyone A + O2 => CO2 + H2O + preaustinoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70458", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21638", "l": "4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP => (E)-4-coumarate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38685", "l": "ADP + H(+) + phosphate + sphing-4-enine(out) => ATP + H2O + sphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009452", "l": "SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73506", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine <=> 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66578", "l": "4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-isopropylphenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37846", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57917", "l": "ATP + L-aspartyl-tRNA(Asn) => 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44273", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35779", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = mutildienyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10596", "l": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25985", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373739", "l": "Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62922", "l": "1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76223", "l": "3',5'-cyclic AMP(in) = 3',5'-cyclic AMP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167408", "l": "The high affinity receptor complex binds to G-protein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76423", "l": "(8S)-annullatin E + dimethylallyl diphosphate = (8S)-annullatin J + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55785", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate => all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63157", "l": "H2O + N-docosanoyl-taurine => docosanoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33598", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855648", "l": "SALM3 binds LAR-RPTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46694", "l": "4-hydroxybenzoyl-5'-AMP + diphosphate => 4-hydroxybenzoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69378", "l": "2-oxododecanoate + H2O2 => 2-hydroxydodecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11383", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 <=> [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38252", "l": "hexadecan-1-ol + octadecanoyl-CoA => CoA + hexadecanyl octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210769", "l": "HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29017", "l": "phosphate(in) + sn-glycerol 3-phosphate(out) => phosphate(out) + sn-glycerol 3-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28043", "l": "CoA + NAD(+) + pyruvate => acetyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728664", "l": "GLP1R binds GLP1R agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13840", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) <=> 4,5-dihydroxyphthalate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982765", "l": "Growth hormone forms dimers and oligomers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43043", "l": "hexadecanoyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295632", "l": "PPA2A dephosphorylates SPRY2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244503", "l": "botE HC:LC binds SV2A or B and GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47760", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29786", "l": "ATP + H2O + L-cysteine(in) <=> ADP + H(+) + L-cysteine(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72328", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate => 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832951", "l": "Expression of ZIC2 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50502", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12991", "l": "a dolichyl phosphate + D-mannose + H(+) => a dolichyl beta-D-mannosyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760402", "l": "ILF3 binds HOXC8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22675", "l": "2 (2E,6E)-farnesyl diphosphate <=> diphosphate + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55593", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O => (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50741", "l": "H2O + leukotriene C4 => glycine + leukotriene F4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173636", "l": "Formation of classic pathway C5 convertase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727188", "l": "ATP4A:ATP4B binds PPIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74433", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50986", "l": "prostaglandin E2(in) => prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209840", "l": "Two DITs combine to form thyroxine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61778", "l": "H(+) + rebaudioside M + UDP => rebaudioside D + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785181", "l": "LMF1,2 bind LIPC dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28555", "l": "D-mannose 6-phosphate + H2O => D-mannose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63056", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56255", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38822", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36926", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018752", "l": "epsilon-caprolactam lactamase activity", "d": ["Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66778", "l": "ADP + H(+) + phosphate + uroporphyrin III(out) => ATP + H2O + uroporphyrin III(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357472", "l": "PAK1-3 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37160", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828024", "l": "SOX17 and TFAP2C bind the NANOG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102313", "l": "1,8-cineole synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) + H2O = 1,8-cineole + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28729", "l": "Cu(2+)(out) + H(+)(out) => Cu(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60279", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74402", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) <=> 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64911", "l": "CTP + 2 H2O <=> CMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52277", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76470", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin B2 <=> 8-demethyltetracenomycin C + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31742", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57371", "l": "H2O + NADPH <=> (6R)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071857", "l": "beta-endorphin receptor binding", "d": ["Binding to a beta-endorphin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27491", "l": "D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate => 2 D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22698", "l": "A + H2O + testololactone => AH2 + androst-4-ene-3,17-dione + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.31", "l": "\"3-hydroxyisobutyrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421835", "l": "trans-Golgi Network Vesicle Scission (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63394", "l": "AH2 + Fe(II)-heme i => A + Fe(II)-heme o + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.67", "l": "\"11-hydroxysugiol 20-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008807", "l": "carboxyvinyl-carboxyphosphonate phosphorylmutase activity", "d": ["Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10044", "l": "cyclohexanol + NAD(+) = cyclohexanone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.245", "l": "\"cyclohexanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391942", "l": "IP receptor can bind prostacyclin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39291", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607733", "l": "BCL10 binds CARD9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036175", "l": "ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695964", "l": "ABHD14B hydrolyses PNPB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070025", "l": "carbon monoxide binding", "d": ["Binding to carbon monoxide (CO)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018521", "l": "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34131", "l": "neryl diphosphate + olivetolate = cannabinerolate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15986", "l": "formate + NAD(+) => CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44894", "l": "an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP => an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31193", "l": "(2E)-decenoyl-CoA + H2O => (3S)-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865276", "l": "PDGF-AB clevage by Furin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37296", "l": "ATP + H2O + L-alanyl-L-threonine(out) => ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64828", "l": "3-hydroxybenzyl alcohol + acetyl-CoA = 3-hydroxy-benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21031", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050683", "l": "AF-1 domain binding", "d": ["Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954513", "l": "NAA translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39360", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69949", "l": "3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416683", "l": "SEMA3E binds to PLXND1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11778", "l": "(9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16440", "l": "glutathione + RX <=> a halide anion + an S-substituted glutathione + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43786", "l": "H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983266", "l": "Kinesins bind microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199456", "l": "PTEN dephosphorylates PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31684", "l": "prosolanapyrone III => (-)-solanapyrone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209792", "l": "N-acetylation of serotonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13588", "l": "ATP + butanoate <=> ADP + butanoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28119", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose => D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77478", "l": "acetyl-CoA + tetrahydroanabasine <=> ammodendrine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44920", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75788", "l": "GTP(in) => GTP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31996", "l": "(2E,6E)-farnesyl diphosphate => 7-epi-sesquithujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33264", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60400", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19878", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72589", "l": "(E)-sinapoyl-CoA + AMP + diphosphate => (E)-sinapate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654425", "l": "Activated FGFR4 binds SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15828", "l": "AZD1979 + H2O <=> AZD1979 oxetane hydrolysis product + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41133", "l": "1-decanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-decanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33298", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54640", "l": "(+)-copalyl diphosphate = (12E)-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.193", "l": "\"(12E)-labda-8(17),12,14-triene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696275", "l": "RND2 binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72860", "l": "3',3',3'-c-tri-AMP + H2O => A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72180", "l": "Cleavage of mRNA at the 3'-end (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727607", "l": "MME:Zn2+ binds sacubitrilat (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0046030", "l": "inositol trisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835121", "l": "Heparin binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047342", "l": "galactose-1-phosphate thymidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707505", "l": "Hemes bind to CLEC1B dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874082", "l": "MET phosphorylates PTK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570528", "l": "SUMOylation of XPC with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046404", "l": "ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39320", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10827", "l": "(S)-malate + NADP(+) <=> H(+) + NADPH + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047986", "l": "hydrogen-sulfide S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12915", "l": "(R)-lipoyl-5'-AMP + diphosphate => (R)-lipoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396370", "l": "VTN binds collagens II, III and V (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173725", "l": "C9 binds C5b:C6:C7:C8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17319", "l": "chlorophyll a + diphosphate => chlorophyllide a + H(+) + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24329", "l": "7,8-dihydrofolate + ATP + formate => 10-formyldihydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043008", "l": "ATP-dependent protein binding", "d": ["Binding to a protein or protein complex using energy from ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41399", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193702", "l": "Part of the ICD migrates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265867", "l": "Formation of RPA-heterotrimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31307", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.265", "l": "\"dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10228", "l": "citrate = cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606160", "l": "p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63655", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56759", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23325", "l": "2'-phospho-[ligated tRNA] + NAD(+) => ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35287", "l": "ATP + chloramphenicol(in) + H2O = ADP + chloramphenicol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6802973", "l": "PLK3 phosphorylates CDC25C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61932", "l": "(S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29803", "l": "ATP + H2O + L-valine(out) = ADP + H(+) + L-valine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30527", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796081", "l": "EIF2AK3 phosphorylates NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14145", "l": "ATP + guanidinoacetate = ADP + H(+) + phosphoguanidinoacetate", "d": [], "t": []}, {"i": "EC:2.7.3.1", "l": "\"guanidinoacetate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19366", "l": "ATP + D-ribulose 5-phosphate => ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16707", "l": "estrone + H(+) + NADPH => 17alpha-estradiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20054", "l": "NAD(+) + ribitol => D-ribulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65300", "l": "2-oxoglutarate + chrodrimanin C + O2 = CO2 + H2O + succinate + verruculide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019535", "l": "ferric-vibriobactin transmembrane transporter activity", "d": ["Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48805", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731002", "l": "CLCN3 exchanges Cl- for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62385", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O => (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10718", "l": "1D-myo-inositol 3-phosphate => D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15609", "l": "ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.6.1", "l": "\"ribose-phosphate diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32972", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64807", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49980", "l": "H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218820", "l": "Src kinases phosphorylate VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24676", "l": "ADP + CMP + H(+) => ATP + cytidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56680", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.27", "l": "\"beta-dihydromenaquinone-9 omega-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22728", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate", "d": [], "t": []}, {"i": "EC:2.9.1.1", "l": "\"L-seryl-tRNA(Sec) selenium transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41529", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH => NAD(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44748", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.223", "l": "\"aminoimidazole riboside kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692867", "l": "HRH3 binds pitosilant (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67559", "l": "3'-phosphoadenylyl sulfate + glycocholate <=> adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31771", "l": "an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033406", "l": "UCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204850", "l": "Interaction of Tie2 and Dok-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950364", "l": "IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59390", "l": "a fatty acid + an aliphatic alcohol + H(+) => a fatty acid ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37987", "l": "delta-tocopherol = 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090079", "l": "GLB1 hydrolyses linker chain(2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948775", "l": "MKRN1 polyubiquitinates PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799431", "l": "TP53 binds HIPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13190", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O => 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75216", "l": "beta-L-fucose + NADP(+) => H(+) + L-fucono-1,5-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21164", "l": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.1", "l": "\"carboxylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429449", "l": "Syk activation leads to SLP-76 activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392513", "l": "Rap1 signal termination by Rap1GAPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34019", "l": "a 1-acylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676041", "l": "Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052585", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound."], "t": []}, {"i": "EC:1.4.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682967", "l": "WHSC1 binds DNA DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57469", "l": "(E)-ferulate + UDP-alpha-D-glucose => 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74367", "l": "substance P(out) = substance P(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27555", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.82", "l": "\"hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18779", "l": "an alkane + Hg(2+) => an alkylmercury + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168950", "l": "TLR6:TLR2 is recruited to ligand:CD14:CD36 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66331", "l": "taurine(out) <=> taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9833777", "l": "PKR binds activating host RNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53834", "l": "a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate => 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848370", "l": "IL18 binds IL18R1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352840", "l": "glucose + ATP => glucose 6-phosphate + ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047237", "l": "glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11899", "l": "7alpha-hydroxycholesterol + NAD(+) <=> 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176175", "l": "Stalling of DNA replication fork and RPA binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797090", "l": "CCNK binds CDK12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51387", "l": "hexadecanoyl-CoA + serotonin <=> CoA + H(+) + N-hexadecanoyl-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928656", "l": "gamma-secretase cleaves EPHB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71164", "l": "homogentisate + O2 => maleylacetoacetate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23704", "l": "GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": [], "t": []}, {"i": "EC:3.5.4.25", "l": "\"GTP cyclohydrolase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975125", "l": "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10606", "l": "a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39206", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56192", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374662", "l": "Translocation of Ezrin to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55383", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) <=> a 3-oxo bile acid CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202164", "l": "Translocation of PDK1 to Plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31414", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617832", "l": "FOXO4:ATXN3 binds SOD2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944225", "l": "Association of procollagen type XVII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878266", "l": "IHH gene transcription is stimulated by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30571", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine = 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.14", "l": "\"enterobactin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19825", "l": "(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.9", "l": "\"aristolochene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13417", "l": "5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin", "d": [], "t": []}, {"i": "EC:1.3.1.41", "l": "\"xanthommatin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167477", "l": "Abortive HIV-1 initiation after formation of the first phosphodiester bond (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38852", "l": "H(+) + tetracenomycin F2 => H2O + tetracenomycin F1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17681", "l": "3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17379", "l": "3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) => a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050661", "l": "NADP binding", "d": ["Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001761", "l": "beta-alanine transmembrane transporter activity", "d": ["Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140696", "l": "factor V -> factor Va + factor V activation peptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909729", "l": "Activation of JAK kinases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781953", "l": "YOD1 binds VCP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940959", "l": "Neurolysin degrades neurotensin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682020", "l": "MRN complex binds shortened telomeres (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390930", "l": "5-HT2 receptor can bind serotonin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74733", "l": "Insulin receptor de-phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41477", "l": "an acyl-CoA + zymosterol => CoA + zymosterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36400", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => H(+) + NADPH + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9645598", "l": "RRAGC,D hydrolyzes GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25175", "l": "L-citrulline + methylamine => H2O + N(omega)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317332", "l": "PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44506", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate => 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63137", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868071", "l": "Clathrin recruits PIK3C2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483186", "l": "PC is converted to PS by PTDSS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43694", "l": "AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] => ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198599", "l": "AKT phosphorylates MDM2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951966", "l": "EP300 acetylates RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11981", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) => bis-gamma-glutamylcystine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016633", "l": "galactonolactone dehydrogenase activity", "d": ["Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36805", "l": "genistein + H(+) + H2O => 2-hydroxy-2,3-dihydrogenistein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046507", "l": "UDPsulfoquinovose synthase activity", "d": ["Catalysis of the reaction: sulfite + UDP-D-glucose = H2O + UDP-6-sulfoquinovose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047848", "l": "dephospho-[reductase kinase] kinase activity", "d": ["Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48520", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.n2", "l": "\"protein-S-isoprenylcysteine alpha-carbonyl methylesterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362386", "l": "Glycosylation of Hh (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22649", "l": "holo-[cytochrome c] => apo-[cytochrome c] + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37392", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39299", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25242", "l": "(S)-2-ureidoglycine + H2O => (S)-ureidoglycolate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003830", "l": "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33773", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52576", "l": "hexanoyl-CoA + NAD(+) = (2E)-hexenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660530", "l": "Expression of SNCB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22254", "l": "a globoside Gb4Cer (d18:1(4E)) + H(+) + UDP => a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696323", "l": "CNRs bind CNR agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63293", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58932", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH = 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.289", "l": "\"aureothin polyketide synthase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45263", "l": "tetracosanoate(out) <=> tetracosanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77618", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol <=> 1-decanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63742", "l": "2-phenylethanol + NAD(+) => 2-phenylacetaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75446", "l": "heme b(in) <=> heme b(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70228", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA => (E)-2-benzylidenesuccinyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32295", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH = 2 diphosphate + NADP(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39111", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37170", "l": "(2E,6E)-farnesol + NAD(+) <=> (2E,6E)-farnesal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43075", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43582", "l": "AH2 + iminoarginine => A + D-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63075", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74260", "l": "H2O + L-homoseryl-tRNA(Lys) => H(+) + L-homoserine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417927", "l": "P2Y2 receptor binds ATP and UTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46936", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = ATP + H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.95", "l": "\"L-2-aminoadipate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004923", "l": "leukemia inhibitory factor receptor activity", "d": ["Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047701", "l": "beta-L-arabinosidase activity", "d": ["Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44211", "l": "12-methyltridecanoate + ATP + CoA <=> 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047683", "l": "aryl-aldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4837364", "l": "Secretion of SOD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28475", "l": "D-glucarate(in) + H(+)(in) => D-glucarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49218", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977375", "l": "CR1 binds C3bBb/C4bC2a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41961", "l": "a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose => a ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71714", "l": "H(+)(out) + L-tyrosylglycine(out) <=> H(+)(in) + L-tyrosylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821395", "l": "PAXIP1 binds PAGR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27400", "l": "4'-demethylrebeccamycin + H2O <=> beta-D-glucose + dichloroarcyriaflavin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25469", "l": "(2E,6E)-farnesyl diphosphate => beta-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654623", "l": "Activated FGFR3 binds FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43807", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72842", "l": "ADP(out) + CoA(in) <=> ADP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30361", "l": "chlorophyllide b + 3 H2O + 2 NADP(+) => chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35542", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 <=> albonoursin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40497", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.315", "l": "\"11-cis-retinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684169", "l": "G6B binds PTPN6,PTPN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626816", "l": "PIN1 binds p-S345-NCF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351936", "l": "Caspase-mediated cleavage of claspin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43919", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247836", "l": "Retromer recycles WLS to the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38560", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate => (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18538", "l": "H2O + NAD(+) + salicylaldehyde => 2 H(+) + NADH + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21217", "l": "ATP + D-ribose 5-phosphate => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44217", "l": "12-hydroxyoctadecanoate + ATP + CoA => 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63546", "l": "kinetensin-(1-8) + L-leucine => H2O + kinetensin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800380", "l": "PTPRD binds IL1RAP-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090595", "l": "acetyl-CoA:L-lysine N6-acetyltransferase", "d": ["Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375138", "l": "CDO binds BOC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392263", "l": "AVP(20-28) binds AVPR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0170009", "l": "endoplasmic reticulum-organelle membrane tether activity", "d": ["The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain membrane contact sites and mediate organelle exchange and communication."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72811", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32714", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58124", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987007", "l": "p-STAT1 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871227", "l": "RET binds GFRA4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33887", "l": "(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.331", "l": "\"secoisolariciresinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72135", "l": "putrescine(out) = putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354077", "l": "Integrin alphaIIb beta3 activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685838", "l": "CX3 complex binds D-loop structures (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52350", "l": "(24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67274", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+) => 1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28736", "l": "H(+)(in) + spermidine(out) => H(+)(out) + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77470", "l": "butan-2-one + hydrogen cyanide <=> 2-hydroxy-2-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53354", "l": "H(+) + NADH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29804", "l": "ATP + H2O + L-valine(out) => ADP + H(+) + L-valine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33976", "l": "DIMBOA beta-D-glucoside + H2O => D-glucose + DIMBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41089", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686731", "l": "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008772", "l": "[isocitrate dehydrogenase (NADP+)] kinase activity", "d": ["Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804276", "l": "ATM phosphorylates TTC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047190", "l": "2-acylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75416", "l": "H2O + N-methylmyosmine => pseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28425", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873923", "l": "STARD10 binds LPCAT1 and PC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868236", "l": "BAR domain proteins recruit dynamin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008735", "l": "L-carnitine CoA-transferase activity", "d": ["Catalysis of the reactions: (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA and 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710101", "l": "CASP4, CASP5 cleave GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57974", "l": "eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59053", "l": "D-lysine + H(+) => cadaverine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49837", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine => (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59330", "l": "D-xylonate + H(+) => D-xylono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35415", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose = an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.295", "l": "\"anthocyanin 3-O-sambubioside 5-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64421", "l": "H(+)(out) + L-alanyl-L-proline(out) => H(+)(in) + L-alanyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676254", "l": "Formation of the MLL3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451900", "l": "IL2RB binds JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627369", "l": "SEPT4 binds XIAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16602", "l": "L-aspartate => fumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0099101", "l": "G-protein gated potassium channel activity", "d": ["A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30967", "l": "9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene", "d": [], "t": []}, {"i": "EC:5.2.1.12", "l": "\"zeta-carotene isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62540", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain = dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40558", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50549", "l": "prostaglandin E1 => H2O + prostaglandin A1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63770", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine => 2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647680", "l": "CASP1 cleaves GSDMD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23765", "l": "diphosphate + L-serine => H(+) + O-phospho-L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218832", "l": "CDC42:GTP binds PAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36164", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate => ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50235", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54966", "l": "hexadecanoyl phosphate + holo-[ACP] => hexadecanoyl-[ACP] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432054", "l": "Aquaporin-1 passively transports water out of cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21711", "l": "H2O + S-adenosyl-L-homocysteine <=> adenosine + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76176", "l": "glycyl-L-glutamate(out) + 3 H(+)(out) => glycyl-L-glutamate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24497", "l": "4-O-deacetylvindoline + acetyl-CoA => CoA + vindoline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12254", "l": "(E)-coniferol + D-glucose => 4-O-(beta-D-glucosyl)-(E)-coniferol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140806", "l": "SERPINC1 binds SERPINC1 activators (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11596", "l": "H(+) + orotidine 5'-phosphate = CO2 + UMP", "d": [], "t": []}, {"i": "EC:4.1.1.23", "l": "\"orotidine-5'-phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30330", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373705", "l": "Caspase cleavage of DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77146", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17391", "l": "D-ribulose + H(+) + NADH => D-arabinitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862380", "l": "HSD17B13 binds lipid droplets (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29247", "l": "3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20629", "l": "H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19902", "l": "L-tryptophan + O2 => alpha,beta-didehydrotryptophan + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682011", "l": "LC3 binds ATG7 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68099", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56410", "l": "1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47358", "l": "an aliphatic alcohol + H(+) + octanoate => an octanoate ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21228", "l": "alpha-maltose = beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015136", "l": "sialic acid transmembrane transporter activity", "d": ["Enables the transfer of sialic acid from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624798", "l": "LBR binds KPNB1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46455", "l": "2 L-leucyl-tRNA(Leu) <=> cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22810", "l": "2,6-dihydroxynicotinate + H2O2 => 6-hydroxynicotinate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234081", "l": "SUMOylation of TFAP2A with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58429", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) => (E,E)-2,4-hexadienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41706", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28298", "l": "(2E,6E)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.59", "l": "\"(E)-gamma-bisabolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59117", "l": "[protein]-dithiol + O2 => [protein]-disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209960", "l": "Diiodinated tyrosine can be deiodinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16913", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.8", "l": "\"CDP-diacylglycerol--serine O-phosphatidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871226", "l": "RET binds GFRA1,GFRA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010815", "l": "SLITs bind keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45289", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 => 2-glyceryl-prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111930", "l": "Adenylate cyclase produces cAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193656", "l": "p75NTR interacts with RIP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163750", "l": "Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351341", "l": "Exocytosis of Proactivator polypeptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0005432", "l": "calcium:sodium antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77068", "l": "Activation of GT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.143", "l": "\"diphosphate-purine nucleoside kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18717", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.84", "l": "\"methylquercetagetin 6-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964498", "l": "DREAM complex binds the CDC6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58094", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75172", "l": "Formation of RAD50:MRE11 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51389", "l": "acetyl-CoA + dopamine => CoA + H(+) + N-acetyl-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668831", "l": "CST complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71500", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44040", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26411", "l": "H2O + N-acetyl-D-muramate 6-phosphate => (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33555", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20453", "l": "scopoletin + UDP-alpha-D-glucose = H(+) + scopolin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.128", "l": "\"scopoletin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708275", "l": "PDE4A binds PDE4A inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12811", "l": "2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O => 4 catechol + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45576", "l": "(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA", "d": [], "t": []}, {"i": "EC:5.4.99.63", "l": "\"ethylmalonyl-CoA mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42090", "l": "all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617194", "l": "Phospho-STAT3 binds the promoter of the CEBPB gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863494", "l": "ASICs bind STOML3, (STOM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140069", "l": "histone butyryltransferase activity", "d": ["Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53773", "l": "chenodeoxycholate + lithocholoyl-CoA => chenodeoxycholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68006", "l": "A + chloride + ethene + H(+) => AH2 + chloroethene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56962", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a ribonucleoside 5'-triphosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0022842", "l": "narrow pore channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867047", "l": "PTPN3 dephosphorylates EPS15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57568", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75168", "l": "CTP + NAD(+) => CDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814766", "l": "GDPD1 hydrolyzes LysoPtdCho (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851062", "l": "AcK685 pY705,S727 STAT3 binds the MIR21 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48689", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine => D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37207", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549364", "l": "Expression of SERPINE1 (PAI-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70737", "l": "chloride(in) + glycine betaine(in) + 2 Na(+)(in) => chloride(out) + glycine betaine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21723", "l": "formamide <=> H2O + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19522", "l": "acetyl-CoA + phosphate => acetyl phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75891", "l": "Abortive Initiation After Second Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804879", "l": "MDM2 ubiquitinates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204773", "l": "Interaction of Tie2 and Grb7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48075", "l": "a ganglioside GM1 (d18:1(4E)) + H2O <=> a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938201", "l": "MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.348", "l": "\"(3R)-2'-hydroxyisoflavanone reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014454", "l": "RHOG translocates to the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63188", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine = A + H2O + norbelladine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39543", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56689", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 => (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30489", "l": "(1E,2S)-2-methylbutanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48994", "l": "1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+) => 1,3,7-trimethylurate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71189", "l": "3-hydroxy-L-kynurenine(in) + L-tryptophan(out) => 3-hydroxy-L-kynurenine(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814096", "l": "ARL1:GTP binds SCOC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69173", "l": "Joining of adjacent Okazaki fragments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68781", "l": "(2Z,6Z)-farnesyl diphosphate => alpha-humulene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70730", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O <=> 6-sulfo-alpha-D-quinovose + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004845", "l": "uracil phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72697", "l": "Start codon recognition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.36", "l": "\"hyaluronoglucuronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174367", "l": "GCL ligates L-Glu to L-Cys (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15918", "l": "an aldopyranose + NAD(+) => aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66614", "l": "methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55768", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55312", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42094", "l": "all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46624", "l": "a D-5-monosubstituted hydantoin = a L-5-monosubstituted hydantoin", "d": [], "t": []}, {"i": "EC:5.1.99.5", "l": "\"hydantoin racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49483", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) <=> H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26140", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O = 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047494", "l": "serine-phosphoethanolamine synthase activity", "d": ["Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39721", "l": "24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868236", "l": "BAR domain proteins recruit dynamin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32122", "l": "GDP-valienol + validamine 7-phosphate <=> GDP + H(+) + validoxylamine A 7'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848713", "l": "PTK6 binds BCAR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15853", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24084", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32843", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662466", "l": "XYLB phosphorylates D-xylulose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707683", "l": "PGRMC2 binds Hemes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41774", "l": "a ganglioside GQ1b (d18:1(4E)) + CMP + H(+) => a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37950", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46056", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621032", "l": "EGR1 binds the TPH1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50214", "l": "11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58410", "l": "H(+) + NADPH + undecanal => NADP(+) + undecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65865", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O => 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77711", "l": "Fe(III)-heme b-[protein] + H2O + nitric oxide = Fe(II)-heme b-[protein] + 2 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39999", "l": "a sphingoid 1-phosphate = a fatty aldehyde + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68190", "l": "CoA + dodecanoate phytyl ester => dodecanoyl-CoA + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65915", "l": "3-hydroxy-L-kynurenine + pyruvate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692749", "l": "CDC14A,B bind MAPK6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34846", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O <=> 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.4", "l": "\"amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0033892", "l": "deoxyribonuclease (pyrimidine dimer) activity", "d": ["Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622129", "l": "FABP5 binds atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783473", "l": "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047297", "l": "asparagine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72389", "l": "2 hydrogencarbonate(in) + sulfate(out) => 2 hydrogencarbonate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654573", "l": "Activated FGFR1 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43001", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74545", "l": "(E,E,E)-alpha-springene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11651", "l": "(-)-menthol + H(+) + NADPH + O2 <=> 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698179", "l": "FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611851", "l": "ADRB2 bind ADR,NAd (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11602", "l": "ADP + CDP => ATP + CMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34998", "l": "L-rhamnose(in) <=> L-rhamnose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944233", "l": "Association of procollagen type XIX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49785", "l": "chenodeoxycholoyl-CoA + taurine => CoA + H(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77091", "l": "ATP + isochorismate + L-glutamate = AMP + diphosphate + H(+) + isochorismoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046962", "l": "sodium-transporting ATPase activity, rotational mechanism", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48291", "l": "a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685953", "l": "SIRT6 deacetylates RBBP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484822", "l": "Kinetochore assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56109", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22628", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.6", "l": "\"phosphoribosylaminoimidazolesuccinocarboxamide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482772", "l": "Release of platelet cytosolic components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74405", "l": "2 (S)-lactate(out) + prostaglandin D2(in) => 2 (S)-lactate(in) + prostaglandin D2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390593", "l": "ATP Hydrolysis By Myosin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41127", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013021", "l": "GDIs block activation of RHOB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71960", "l": "3 Na(+)(out) + oxaloacetate(out) => 3 Na(+)(in) + oxaloacetate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112037", "l": "Inactivation of PLC beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66243", "l": "ATP + CoA + IC-asc-C9 <=> AMP + diphosphate + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36661", "l": "novobiocin + phosphate => carbamoyl phosphate + descarbamoylnovobiocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75733", "l": "10-oxo-(12Z)-octadecenoate + H(+) + NADH => (10S)-hydroxy-(12Z)-octadecenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177922", "l": "EGFR dimerization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802918", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46546", "l": "an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851866", "l": "MET binds RANBP10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804099", "l": "HMGB1 binds LTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65160", "l": "benzoyl-CoA + hexan-2-ol = CoA + hexan-2-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50822", "l": "H(+) + NADPH + testosterone => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61284", "l": "H2O + L-cystine + O2 = (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445700", "l": "Myosin Binds ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214860", "l": "CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72468", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35883", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63644", "l": "GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62821", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57747", "l": "[protein]-disulfide + phylloquinol <=> [protein]-dithiol + phylloquinone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16259", "l": "alpha-D-glucose + alpha-D-glucose 1-phosphate => alpha,alpha-trehalose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018528", "l": "iminodiacetate dehydrogenase activity", "d": ["Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130619", "l": "TGN-lysosomal vesicle coat assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983158", "l": "Trimming of peptides in ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983153", "l": "E1 mediated ubiquitin activation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690449", "l": "S1PR1 bind S1P (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54998", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.23", "l": "\"matrilysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814838", "l": "Defective GYG1 is not autoglucosyolated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351948", "l": "Mitochondrial recruitment of Drp1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25905", "l": "futalosine + H2O => dehypoxanthine futalosine + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71066", "l": "L-arginine(in) + L-histidine(out) <=> L-arginine(out) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43079", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16326", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP => diphosphate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62234", "l": "a thymidine dimer in DNA => a thymidine(6-4)thymidine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70880", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) => L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19266", "l": "carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30767", "l": "D-glucurono-3,6-lactone + H2O = D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40206", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67285", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174367", "l": "GCL ligates L-Glu to L-Cys (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68476", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) = a fatty aldehyde + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29304", "l": "2 H(+)(in) + succinate(in) => 2 H(+)(out) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52774", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218812", "l": "FYN phosphorylates PAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64235", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59137", "l": "ATP + citrate + D-ornithine => AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16256", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) <=> H(+) + NADH + phenanthrene-3,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430308", "l": "PARVB interacts with Alpha-actinin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420977", "l": "Ca permeable AMPA receptor ligand binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.318", "l": "\"eugenol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16563", "l": "hopan-22-ol => H2O + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34647", "l": "S-adenosyl-L-methionine + squalene = 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14120", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50958", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75908", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] => ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53812", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38701", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69200", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44642", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + ADP => a 2'-deoxyribonucleoside 5'-diphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156678", "l": "Activation of Cdc25C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876472", "l": "NPC2 binds CHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23341", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate => D-arabinose + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.16", "l": "\"citrate synthase (unknown stereospecificity)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901047", "l": "Binding of ERp57 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36600", "l": "hydrogen sulfide + NAD(+) => NADH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35817", "l": "4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate => 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877338", "l": "RUNX1 and NFATC2 bind the IL2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18721", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = diphosphate + ent-13-epi-manoyl oxide", "d": [], "t": []}, {"i": "EC:4.2.3.186", "l": "\"ent-13-epi-manoyl oxide synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21339", "l": "NAD(+) + pyridoxal <=> 4-pyridoxolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.58", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009282", "l": "CDK1 phosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824236", "l": "MSGN1 and LEF1:CTNNB1 bind the DLL1 gene in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22903", "l": "(R)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36362", "l": "2 a plastoquinone + 2 H2O + 4 hnu <=> 2 a plastoquinol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67236", "l": "mycophenolyl-CoA + propanoyl-CoA = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213241", "l": "Formation of nonameric complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928656", "l": "gamma-secretase cleaves EPHB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52693", "l": "3-phenyllactate + NADP(+) => 3-phenylpyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73447", "l": "acetyl-CoA(in) + AMP(out) = acetyl-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708557", "l": "FBXL17 binds BACH1:MAFK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32531", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.281", "l": "\"4-O-beta-D-mannosyl-D-glucose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103063", "l": "trans-keto-C61-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] = diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27852", "l": "CoA + H(+) + phenylacetylglycine => glycine + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53040", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32886", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) <=> (+)-artemisinic aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15625", "l": "Co-precorrin-6B + NAD(+) = Co-precorrin-6A + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.106", "l": "\"cobalt-precorrin-6A reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35418", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose <=> an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42129", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74783", "l": "tyramine(in) = tyramine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71170", "l": "glycine(out) + H(+)(in) + Na(+)(out) <=> glycine(in) + H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681694", "l": "TNC binds Syndecan-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59168", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate = AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36573", "l": "CoA + H(+) + N-(tetradecanoyl)-sphinganine => sphinganine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30607", "l": "A + all-trans-phytofluene = AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76292", "l": "Na(+)(out) + xanthine(out) => Na(+)(in) + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708275", "l": "PDE4A binds PDE4A inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55215", "l": "(2R)-hydroxyhexadecanoyl-CoA <=> formyl-CoA + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46741", "l": "7-dehydrodesmosterol + H(+) + NADPH => desmosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19213", "l": "acetyl-CoA + an S-substituted L-cysteine = an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.80", "l": "\"cysteine-S-conjugate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40813", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23389", "l": "ATP + hygromycin B => 7''-O-phosphohygromycin B + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46727", "l": "(2S)-2-methyltetradecanoyl-CoA <=> (2R)-2-methyltetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9823816", "l": "OPTN binds CASP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956608", "l": "MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217147", "l": "Phosphorylation of c-Abl and Arg by ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168638", "l": "Activated IKK phosphorylates I-kappaB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54329", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH => hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16598", "l": "ATP + NH4(+) + UTP => ADP + CTP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043015", "l": "gamma-tubulin binding", "d": ["Binding to the microtubule constituent protein gamma-tubulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63800", "l": "GDP-alpha-D-mannose = GDP-beta-L-gulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15873", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.242", "l": "\"NDP-glucose--starch glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047736", "l": "cellobiose epimerase activity", "d": ["Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0019862", "l": "IgA binding", "d": ["Binding to an immunoglobulin of an IgA isotype."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023460", "l": "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212380", "l": "Formation of TRAP coactivator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788622", "l": "p-Y-STATs dimerize (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166387", "l": "The FA anion diffuses away laterally from UCP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790907", "l": "Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45033", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine => 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029270", "l": "Recruitment of PLCgamma to membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56219", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429449", "l": "Syk activation leads to SLP-76 activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71411", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) = 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333678", "l": "CPNEs bind PL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33616", "l": "ATP + CoA + octadecanoate => AMP + diphosphate + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77503", "l": "3-phenylpropanal + hydrogen cyanide = (2S)-2-hydroxy-4-phenylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24501", "l": "adenosine 5'-tetraphosphate + H2O => ATP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35177", "l": "novobiocin(out) => novobiocin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392749", "l": "Transport of L1 into endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36313", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH => 3,4-dihydroxybenzaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20471", "l": "D-ribose 5-phosphate + hypoxanthine => H2O + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26449", "l": "3-oxopropanoate + CoA + NADP(+) <=> H(+) + malonyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029680", "l": "Caspase-7 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.12", "l": "\"glucuronate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608039", "l": "NR1H2,3 binds the PLIN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015117", "l": "thiosulfate transmembrane transporter activity", "d": ["Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other."], "t": []}, {"i": "RHEA:32807", "l": "thiosulfate(in) = thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45320", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine = H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62576", "l": "ATP + H2O + L-cystine(out) = ADP + H(+) + L-cystine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120328", "l": "ATP-dependent DNA (cytosine-5-)-methyltransferase activity", "d": ["Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis."], "t": []}, {"i": "RHEA:68984", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46048", "l": "D-galactosamine 6-phosphate = alpha-D-galactosamine 1-phosphate", "d": [], "t": []}, {"i": "EC:5.4.2.13", "l": "\"phosphogalactosamine mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944457", "l": "MAF1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44279", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32371", "l": "all-trans-violaxanthin + 2 L-ascorbate = all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": [], "t": []}, {"i": "EC:1.23.5.1", "l": "\"violaxanthin de-epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172126", "l": "DAP12 interacts with NKG2C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56924", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047662", "l": "aminobenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865605", "l": "BRWD1 binds SMARCA4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18908", "l": "H2O + phosphonoacetaldehyde <=> acetaldehyde + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15693", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 = (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19093", "l": "2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2", "d": [], "t": []}, {"i": "EC:4.1.1.111", "l": "\"siroheme decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050069", "l": "lysine dehydrogenase activity", "d": ["Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25773", "l": "2-oxoglutarate + L-asparagine + O2 => (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004476", "l": "mannose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68944", "l": "esculetin + S-adenosyl-L-methionine = H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73642", "l": "CTP(out) + ITP(in) <=> CTP(in) + ITP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32497", "l": "(6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13639", "l": "H2O + methanol + NAD(+) => H(+) + methane + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665411", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804100", "l": "HMGB1 binds LPS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396399", "l": "Fibrillins bind BMPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66438", "l": "H(+) + NADPH + pent-1-en-3-one => NADP(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50990", "l": "prostaglandin F2alpha(in) => prostaglandin F2alpha(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663132", "l": "p-BMAL1:p-CLOCK,NPAS2 binds DBP gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204465", "l": "Basigin interacts with CD43 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253343", "l": "WWOX binds ERBB4s80 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36747", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.303", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631885", "l": "PRDX1 overoxidizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099100", "l": "G-protein gated monoatomic cation channel activity", "d": ["A cation channel activity that is gated by binding of a G-protein beta-gamma dimer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50860", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070123", "l": "transforming growth factor beta receptor activity, type III", "d": ["Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451826", "l": "YKI binds to EX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213241", "l": "Formation of nonameric complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65987", "l": "hnu + previtamin D3 <=> lumisterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35739", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}, {"i": "EC:1.14.15.6", "l": "\"cholesterol monooxygenase (side-chain-cleaving)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37411", "l": "aklavinone + NADP(+) = aklaviketone + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.362", "l": "\"aklaviketone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390835", "l": "DRD1,5 bind DA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44225", "l": "16-hydroxyhexadecanoate + ATP + CoA => 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12058", "l": "4-phospho-D-erythronate + 2 H(+) + NADH => D-erythrose 4-phosphate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53115", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63887", "l": "H2O2 + L-tyrosine <=> H2O + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873919", "l": "Phosphorylation of JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865276", "l": "PDGF-AB clevage by Furin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75483", "l": "estrone 3-sulfate(out) + n H(+)(out) = estrone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795473", "l": "PDPK1 phosphorylates SGK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23509", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O => (7R)-7-aminocephalosporanate + glutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31778", "l": "all-trans-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22274", "l": "(20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22482", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65441", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47116", "l": "eicosanoate + glycine = H2O + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40363", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60872", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33930", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 <=> 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23940", "l": "D-gluconate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668605", "l": "RAC2:GTP binds NOX2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36402", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) <=> H(+) + NADPH + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16355", "l": "L-glutamate + sulfoacetaldehyde => 2-oxoglutarate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76557", "l": "1-(ergostan-3beta-yl)-L-aspartate + tRNA(Asp) => ergosterol + L-aspartyl-tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20500", "l": "a 2-arylethylamine + acetyl-CoA <=> an N-acetyl-2-arylethylamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507873", "l": "Aquaporins passively transport urea out of cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67614", "l": "a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27917", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56685", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45882", "l": "4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57665", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.53", "l": "\"beta-N-acetylgalactosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944457", "l": "MAF1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34935", "l": "2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39225", "l": "(2E)-octacosenoyl-CoA + H2O => (3R)-hydroxyoctacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.98.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50937", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate => acetoacetyl-CoA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375138", "l": "CDO binds BOC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782943", "l": "UV-DDB ubiquitinates XPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836256", "l": "RSV sG binds TLR2:TLR6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33416", "l": "bornane-2,6-dione + H2O => [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19478", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53525", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850961", "l": "PREX2 binds PTEN and inhibits it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650165", "l": "ASIC trimers bind H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60123", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine <=> H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16508", "l": "chorismate <=> 4-hydroxybenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70266", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.11", "l": "\"3-oxo-Delta(1)-steroid hydratase/dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693243", "l": "RHOD translocates to the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67051", "l": "AH2 + chermesin D + O2 <=> A + asnovolin I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58674", "l": "aldehydo-D-glucuronate => D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27285", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209377", "l": "Polymeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35467", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.269", "l": "\"dimethylsulfoniopropionate demethylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64736", "l": "4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14967", "l": "a carboxylate + H(+) + phosphate => an acyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52214", "l": "ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43437", "l": "coproporphyrinogen III + 3 O2 => coproporphyrin III + 3 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44583", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) <=> 2-all-trans-decaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49501", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15523", "l": "CoA + H(+) + N-tetradecanoylglycyl-[protein] => N-terminal glycyl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015643", "l": "toxic substance binding", "d": ["Binding to a toxic substance, a poisonous substance that causes damage to biological systems."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59426", "l": "benzaldehyde + H2O2 + NH4(+) => benzylamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17457", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine = [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14026", "l": "H(+) + H2O + sepiapterin => NH4(+) + xanthopterin-B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70241", "l": "PCK1 phosphorylates OA to yield PEP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18711", "l": "AH2 + NH4(+) + sulfoacetaldehyde => A + H2O + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72363", "l": "chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690873", "l": "ACO1 binds 4Fe-4S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43583", "l": "A + D-arginine <=> AH2 + iminoarginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74726", "l": "Dissociation of insulin from insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196753", "l": "2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10338", "l": "D-threo-isocitrate => citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33069", "l": "(4R)-hydroxysphinganine + phosphate => (4R)-hydroxysphinganine 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11464", "l": "2 glutathione + L,L-homocystine = glutathione disulfide + 2 L-homocysteine", "d": [], "t": []}, {"i": "EC:1.8.4.1", "l": "\"glutathione--homocystine transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38464", "l": "a 1-acyl-sn-glycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45982", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+) => 3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13805", "l": "A + a 3-oxo-5alpha-steroid = a 3-oxo-Delta(4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42439", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12899", "l": "(+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44568", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) = 2-all-trans-hexaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14863", "l": "H(+) + NADPH + orotate => (S)-dihydroorotate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102173", "l": "24-methylenecycloartanol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20934", "l": "dihydroxyacetone phosphate + formaldehyde => L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68504", "l": "(2Z,6Z)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2974737", "l": "NOTCH2 binds MDK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62214", "l": "gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795473", "l": "PDPK1 phosphorylates SGK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084912", "l": "Arresten binds integrin alpha1beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22411", "l": "dimethylallyl diphosphate + isopentenyl diphosphate <=> (2E)-geranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005159", "l": "insulin-like growth factor receptor binding", "d": ["Binding to an insulin-like growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682769", "l": "LGI2 binds ADAM22,23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30752", "l": "ATP + CoA + hexadecanoate => AMP + diphosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032775", "l": "YAP1 binds TEAD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59457", "l": "NADP(+) + tetradecan-1-ol => H(+) + NADPH + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559439", "l": "CD14:LPS binds CR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37099", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75274", "l": "S-adenosyl-L-methionine + serotonin <=> 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.57", "l": "\"AMP phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44439", "l": "a 1,2-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76010", "l": "(3R)-hydroxybutanoate pentamer + H2O <=> (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38349", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate => (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18355", "l": "ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate => ATP + H2O + K(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77012", "l": "(2S)-2-amino-3-methylbutan-1-ol + H2O + NAD(+) => 1-hydroxy-3-methylbutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102367", "l": "2-alpha-hydroxytaxusin 7-beta-hydroxylase activity", "d": ["Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7beta-dihydroxytaxusin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443779", "l": "Linkage of L1 with treadmilling F-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49878", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30863", "l": "4-O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16914", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421831", "l": "trans-Golgi Network Coat Assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38553", "l": "(R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35023", "l": "hydroquinone O-beta-D-glucopyranoside(out) = hydroquinone O-beta-D-glucopyranoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004416", "l": "hydroxyacylglutathione hydrolase activity", "d": ["Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015567", "l": "alkane transmembrane transporter activity", "d": ["Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22938", "l": "acetate + D-glucosamine 6-phosphate => H2O + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72023", "l": "nicotinate(in) + urate(out) = nicotinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62389", "l": "[(1->2)-beta-D-glucosyl](n) + H2O => [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21677", "l": "2 dimethylallyl diphosphate => (R)-lavandulyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252001", "l": "ATP1B4 binds SNW1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14881", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) = asparagusate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.8.1.11", "l": "\"asparagusate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64057", "l": "(1S,2R)-ephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0061599", "l": "molybdopterin molybdotransferase activity", "d": ["Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427404", "l": "Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11566", "l": "alpha-D-glucose 1-phosphate + D-gluconate => 4-O-beta-D-glucopyranosyl-D-gluconate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30337", "l": "NH4(+) + UTP => CTP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768930", "l": "NPAS4 binds MDM2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47213", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37295", "l": "ATP + H2O + L-alanyl-L-threonine(out) = ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72707", "l": "GDP-beta-L-fucose(in) + GMP(out) = GDP-beta-L-fucose(out) + GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14838", "l": "glyoxylate + H2O + O2 => H(+) + H2O2 + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14868", "l": "S-adenosyl-L-methionine + tyramine <=> H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55580", "l": "ATP + H2O + L-glutamine = AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": [], "t": []}, {"i": "EC:2.7.3.13", "l": "\"glutamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42851", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50451", "l": "AH2 + prostaglandin G3 <=> A + H2O + prostaglandin H3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64162", "l": "ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase] => ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008918", "l": "lipopolysaccharide 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167427", "l": "Opioid dissociates from MOR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31288", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA => acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62782", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72993", "l": "2 Na(+)(in) + scyllo-inositol(in) => 2 Na(+)(out) + scyllo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102446", "l": "rhamnetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28498", "l": "formaldehyde + mycothiol = S-(hydroxymethyl)mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473186", "l": "FSTL3 binds Activin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16196", "l": "an (R)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218806", "l": "FYN autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72776", "l": "7-carboxymellein + ATP + L-phenylalanine => ADP + H(+) + ochratoxin B + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34526", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59029", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004055", "l": "argininosuccinate synthase activity", "d": ["Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31819", "l": "(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.90", "l": "\"5-epi-alpha-selinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432946", "l": "PARVB/Affixin interacts with alpha PIX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788611", "l": "HYKK phosphorylates 5HLYS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804379", "l": "PRMT5 binds TTC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47081", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77607", "l": "2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12550", "l": "2-cis-(+)-abscisic aldehyde + H(+) + NADH => 2-cis,4-trans-xanthoxin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691131", "l": "CANDI binds CUL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22987", "l": "carbamoyl phosphate + oxamate <=> N-carbamoyl-2-oxoglycine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36869", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74057", "l": "D-cysteine(in) + L-alanine(out) => D-cysteine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24357", "l": "a 1-acyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70431", "l": "2 H(+)(out) + Li(+)(in) = 2 H(+)(in) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2299620", "l": "Collagen XI cross-links with collagen II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72414", "l": "inulobiose <=> alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018510", "l": "phloroglucinol reductase activity", "d": ["Catalysis of the reaction: dihydrophloroglucinol + NADP+ = H+ + NADPH + phloroglucinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66563", "l": "(R)-noradrenaline + L-glutaminyl-[protein] <=> 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62763", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39932", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008692", "l": "3-hydroxybutyryl-CoA epimerase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160123", "l": "structural constituent of nuclear lamina", "d": ["The action of a molecule that contributes to the structural integrity of nuclear lamina."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873794", "l": "PCTP binds PC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071837", "l": "HMG box domain binding", "d": ["Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16589", "l": "A + sucrose = 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.13", "l": "\"glucoside 3-dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17624", "l": "acetyl-CoA + citramalate <=> (3S)-citramalyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20653", "l": "23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57078", "l": "(2R)-3-phosphoglycerate + glycolate + H(+) => 3-oxoisoapionate 4-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090729", "l": "toxin activity", "d": ["Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760402", "l": "ILF3 binds HOXC8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678327", "l": "MIOX oxidises Ins to GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12349", "l": "(S)-muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40548", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60905", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21238", "l": "2,3-dihydroxybenzoate + NADP(+) + NH4(+) => anthranilate + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56089", "l": "a globoside MSGG + CMP-N-acetyl-beta-neuraminate => a globoside DSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41358", "l": "geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH => bacteriochlorophyll a + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.151319539368089", "identifiers": [{"i": "GO:0008528", "l": "G protein-coupled peptide receptor activity", "d": ["Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23801", "l": "H2O + L-methionine => 2-oxobutanoate + methanethiol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400204", "l": "PPARA binds RXRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60013", "l": "a tRNA with a 3' CC end + ATP => a tRNA with a 3' CCA end + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69152", "l": "Removal of remaining Flap (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61307", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose <=> H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15747", "l": "[(2->1)-beta-D-fructosyl](n+1) + D-glucose => [(2->1)-beta-D-fructosyl](n) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16335", "l": "diphosphate + holo-[citrate lyase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807008", "l": "PTPRJ dephosphorylates MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018756", "l": "RHOH binds GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350058", "l": "Formation of CSL NCOR corepressor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76786", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,9-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71321", "l": "chloride(in) + L-cysteine(in) + 2 Na(+)(in) => chloride(out) + L-cysteine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.108", "l": "\"UDP-3-O-acyl-N-acetylglucosamine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000263", "l": "TCN2:RCbl is degraded to release RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428260", "l": "DEGS2 oxygenates dihydroceramide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334827", "l": "SUMO-CRABP2 binds atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46134", "l": "25-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19799", "l": "1D-myo-inositol 1,4-bisphosphate + phosphate => 1D-myo-inositol 1,4,5-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103011", "l": "mannosylfructose-phosphate synthase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate = mannosylfructose-phosphate + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50143", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19841", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.12", "l": "\"formylmethanofuran dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54583", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP <=> a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31549", "l": "15-cis-4,4'-diapophytoene + 2 diphosphate => 2 (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59857", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium => methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17878", "l": "a catechol + S-adenosyl-L-methionine => a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033826", "l": "xyloglucan 4-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44291", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1454916", "l": "The ABCC family mediates organic anion transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59912", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159259", "l": "MMAA:MUT binds AdoCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1358791", "l": "Phosphorylation of USP8 by P-AKT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004864", "l": "protein phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50483", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53559", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607736", "l": "MALT1 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56478", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016297", "l": "fatty acyl-[ACP] hydrolase activity", "d": ["Catalysis of the reaction: a fatty acyl-[ACP] + H2O = a fatty acid + H(+) + holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39151", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714691", "l": "RAC3 binds ER effectors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209322", "l": "In the absence of ARM, GRO binds to PAN and inhibits transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68387", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138432", "l": "DVL2 is phosphorylated by PKC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71998", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + preaspterpenacid acid I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042656", "l": "JUN kinase kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56397", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54394", "l": "(9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607721", "l": "Activation of NIK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77068", "l": "Activation of GT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27554", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate <=> di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5623643", "l": "RDH13 reduces atRAL to atROL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844241", "l": "ADAMTS13 cleaves VWF variant multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74867", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) = (E)-caffeoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801776", "l": "REG3A binds bacterial phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.496617203483822", "identifiers": [{"i": "GO:0016891", "l": "RNA endonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66911", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36479", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27947", "l": "dopamine + H2O + O2 => 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45097", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0090580", "l": "phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "d": ["Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63545", "l": "H2O + kinetensin => kinetensin-(1-8) + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65194", "l": "berkeleytrione + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 2 O2 + preaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46835", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44057", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710254", "l": "GSDME oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046978", "l": "TAP1 binding", "d": ["Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29182", "l": "a menaquinol + 2 O2 <=> a menaquinone + 2 H(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008922", "l": "long-chain fatty acid [acyl-carrier-protein] ligase activity", "d": ["Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352268", "l": "Cleavage of Satb1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11635", "l": "AH2 + L-selenocysteine <=> A + H(+) + hydrogenselenide + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57429", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] => formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756150", "l": "PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851142", "l": "TYK2-dependent STAT1 and STAT3 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56071", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.85", "l": "\"7-deoxyloganate 7-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:1990814", "l": "DNA/DNA annealing activity", "d": ["An activity that faciliates the formation of a complementary double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685600", "l": "viral HA binds NCRI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785607", "l": "FANCM binds FAAP24 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201717", "l": "CSNK2-mediated phosphorylation of DVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050276", "l": "scyllo-inosamine 4-kinase activity", "d": ["Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.67228564893351", "identifiers": [{"i": "GO:0035251", "l": "UDP-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule."], "t": []}, {"i": "REACT:R-HSA-1912353", "l": "Glucosylation of Pre-NOTCH by POGLUT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047613", "l": "aconitate decarboxylase activity", "d": ["Catalysis of the reaction: cis-aconitate + H+ = CO2 + itaconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30418", "l": "H(+) + 2 NADPH + O2 + octadecanal <=> formate + H2O + heptadecane + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61414", "l": "ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine => ATP + N-(D-erythrulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70442", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37346", "l": "adenosine 2'-phosphate + H2O <=> adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56656", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1170539", "l": "Prolactin receptor is internalized (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32553", "l": "(S)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392749", "l": "Transport of L1 into endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76844", "l": "H2O + NAD(+) + octylamine => H(+) + NADH + NH4(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45506", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24342", "l": "(R)-acetoin + H(+) + NADH => (R,R)-butane-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72357", "l": "dehydroepiandrosterone 3-sulfate(in) + glutarate(out) => dehydroepiandrosterone 3-sulfate(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61196", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23608", "l": "H(+) + H2O + N-isopropylammelide = cyanurate + isopropylamine", "d": [], "t": []}, {"i": "EC:3.5.4.42", "l": "\"N-isopropylammelide isopropylaminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549129", "l": "OCT1 transports organic cations into hepatic cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2301205", "l": "SETD8 monomethylates histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47266", "l": "AMP + diphosphate + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18809", "l": "L-alanine + oxomalonate = aminomalonate + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.47", "l": "\"alanine--oxomalonate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112755", "l": "SOCS3 binds IL6ST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25107", "l": "ATP + pyridoxamine <=> ADP + H(+) + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29585", "l": "guanosine(out) + H(+)(in) => guanosine(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28892", "l": "H(+)(in) + putrescine(in) => H(+)(out) + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.2.3", "l": "\"trimethylamine-N-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47013", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.593242189043409", "identifiers": [{"i": "GO:1901363", "l": "heterocyclic compound binding", "d": ["Binding to heterocyclic compound."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42275", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65161", "l": "benzoyl-CoA + hexan-2-ol => CoA + hexan-2-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428262", "l": "ACER3 hydrolyzes phytoceramide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17634", "l": "a beta-D-glucuronoside + H2O => an alcohol + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614933", "l": "ACEIs bind ACE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19519", "l": "dimethylamine + formate => H2O + N,N-dimethylformamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354073", "l": "Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69919", "l": "inosine(out) + 2 Na(+)(out) = inosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19787", "l": "clavaminate + CO2 + H2O + succinate => 2-oxoglutarate + dihydroclavaminate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75300", "l": "NAD(+) => 2'cADPR + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56026", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30488", "l": "H(+) + N,N-dihydroxy-L-isoleucine => (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444202", "l": "Receptor FFAR1 binds free fatty acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18128", "l": "A + a D-alpha-amino acid + H2O <=> a 2-oxocarboxylate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448963", "l": "Interaction of MyoD:E protein with MEF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70343", "l": "chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.25", "l": "\"L-arginine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20208", "l": "methylazoxymethanol + UDP-alpha-D-glucose <=> cycasin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67151", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 <=> 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098614", "l": "hydrogen selenide methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol."], "t": []}, {"i": "REACT:R-HSA-2408536", "l": "H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45689", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.199", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425861", "l": "Activation of Protein Kinase C novel isoforms (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69807", "l": "benzoyl-AMP + CoA = AMP + benzoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202709", "l": "JAM2 dimerises (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10326", "l": "a 2-hydroxycarbonyl + H(+) + NADPH => an L-glycol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732629", "l": "PPARG binds PPARG agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54263", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52447", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31913", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate => beta-D-fructose 1,6-bisphosphate + methylglyoxal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60701", "l": "a 1-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9656893", "l": "OPN1MW binds 11cRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190261", "l": "FGFR3c binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389381", "l": "Gads binds CD28 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620456", "l": "sGC stimulators bind sGC:NO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327746", "l": "FN1 aggregation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64329", "l": "(7Z)-octadecenoyl-CoA + cholesterol => cholesteryl (7Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50495", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390641", "l": "ADRA1A,B,D bind ADR,NAd (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29643", "l": "D-maltoheptaose + H2O = alpha-D-glucose + D-maltohexaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730856", "l": "Autophosphorylation of PAK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753634", "l": "GGT dimers hydrolyse APAP-SG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14704", "l": "2 CoA + NAD(+) <=> CoA-disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52554", "l": "3-dehydro-4-O-phospho-L-erythronate + ADP + H(+) => 3-dehydro-L-erythronate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48627", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373705", "l": "Caspase cleavage of DCC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76319", "l": "L-aspartate(in) + L-leucine(out) = L-aspartate(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193981", "l": "CYP21A2 oxidises 17HPROG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.70", "l": "\"7-deoxycylindrospermopsin hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47854", "l": "a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174171", "l": "Association of Cyclin A with the APC/C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.3", "l": "\"NAD(P)(+) transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68656", "l": "7-oxocholesterol + H(+) + NADPH = 7beta-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090486", "l": "small RNA 2'-O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10971", "l": "a carboxylate + CoA + GTP <=> an acyl-CoA + GDP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140827", "l": "zinc chaperone activity", "d": ["Binding to and delivering zinc ions to a target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741411", "l": "CYLD deubiquitinates NEMO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18672", "l": "adenosine + H2O <=> adenine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52742", "l": "aminomethylphosphonate + glyoxylate + H(+) + H2O2 => glyphosate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66828", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35325", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34716", "l": "15-methylhexadecasphing-4-enine + ATP => 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050046", "l": "delta7-sterol 5(6)-desaturase activity", "d": ["Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69516", "l": "N-acetyl-D-galactosamine + O2 = H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19390", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52752", "l": "H2O + isomaltose = beta-D-glucose + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.205", "l": "\"isomaltose glucohydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001734", "l": "mRNA (N6-adenosine)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U."], "t": []}, {"i": "REACT:R-HSA-72095", "l": "Internal Methylation of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63487", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70782", "l": "D-glucose + NADP(+) <=> 6-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031423", "l": "hexon binding", "d": ["Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013147", "l": "RAC1 GDIs block activation of RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47184", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28797", "l": "2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14340", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32874", "l": "a 2-acylglycerol + H2O <=> a carboxylate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75512", "l": "acetyl-CoA + S-benzyl-L-cysteine => CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19689", "l": "L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.19", "l": "\"rhamnulose-1-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44373", "l": "Cr(6+) + 2 NADH + O2 => Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3134962", "l": "DHX36 binds DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65711", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48910", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635839", "l": "ULK3:SUFU dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58501", "l": "glycine betaine + H(+) + NADH + O2 => glyoxylate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56898", "l": "an acyl-AMP + diphosphate => a carboxylate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751051", "l": "GSH cleaves AZA to 6MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30939", "l": "ATP + dIDP = ADP + dITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68960", "l": "DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004611", "l": "phosphoenolpyruvate carboxykinase activity", "d": ["Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696947", "l": "USP47 deubiquitinates POLB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67862", "l": "3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45399", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11568", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP = 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": [], "t": []}, {"i": "EC:2.1.1.54", "l": "\"deoxycytidylate C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41187", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50221", "l": "(S)-demethyl-4-deoxygadusol => (R)-demethyl-4-deoxygadusol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16575", "l": "(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate => 2-oxoglutarate + 4-(phosphooxy)-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047177", "l": "glycerophospholipid arachidonoyl-transferase (CoA-independent) activity", "d": ["Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683455", "l": "nsp16 binds VHL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24477", "l": "H2O + maleimide => H(+) + maleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72742", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) <=> chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52807", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-eremophilene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353268", "l": "Binding of Pol zeta complex to a DNA template containing lesions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.364", "l": "\"protopanaxadiol-type ginsenoside 3-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139898", "l": "Caspase-8 activates BID by cleavage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34294", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose <=> 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56584", "l": "1,2-epoxypropane + H2O = propane-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76268", "l": "carnosine(in) => carnosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036008", "l": "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26176", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.1.13", "l": "\"L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62346", "l": "diphosphate + notoamide S => 6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349455", "l": "Phosphorylation of MDM4 by ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42945", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204873", "l": "Interaction of Tie2 and Shp2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66189", "l": "3',5'-cyclic GMP(in) + ATP + H2O => 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381290", "l": "PPARG:RXRA heterodimer binds to PPARG corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.17", "l": "\"stromelysin 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67598", "l": "CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848077", "l": "PTK6 phosphorylates STAP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77512", "l": "2-methoxybenzaldehyde + hydrogen cyanide => (2S)-2-hydroxy-2-(2-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793176", "l": "DS is cleaved from its proteoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32147", "l": "H2O + sepiapterin = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417890", "l": "P2Y5 receptor can bind to LPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835411", "l": "FA core complex:HSP70s binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419389", "l": "LPA-binding receptors bind LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21362", "l": "diphosphate + NAD(+) => ATP + beta-nicotinamide D-ribonucleotide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16277", "l": "H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.7", "l": "\"indole-3-acetaldehyde oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202947", "l": "Caspase mediated cleavage of APC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.37", "l": "\"xylan 1,4-beta-xylosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57019", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428609", "l": "Type I Na+-coupled phosphate co-transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32805", "l": "ADP + H(+) + phosphate + urea(in) => ATP + H2O + urea(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877396", "l": "IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007901", "l": "IL1F10 binds IL1RL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74250", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54087", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine <=> archaeosine(15) in tRNA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035484", "l": "CysS248-MPST:TXN2 dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806629", "l": "Formation of tonofilament bundles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051120", "l": "hepoxilin A3 synthase activity", "d": ["Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37448", "l": "O2 + tetracenomycin F1 => H(+) + H2O + tetracenomycin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13705", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine = alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.138", "l": "\"mannotetraose 2-alpha-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193668", "l": "p75NTR and RHOA-GDI interact (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71849", "l": "LDH tetramer reduces PYR to LACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17064", "l": "H(+) + NADPH + O2 + phenol <=> catechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64114", "l": "a fatty acid + L-phenylalanine => an N-acyl-L-phenylalanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944227", "l": "Association of procollagen type XXII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.-", "l": "\"Carboxylic ester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31577", "l": "8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68432", "l": "lutein + O2 = (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660819", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.755473255981116", "identifiers": [{"i": "GO:0016803", "l": "ether hydrolase activity", "d": ["Catalysis of the hydrolysis of an ether bond, -O-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58296", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64487", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA <=> 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10054", "l": "4-methyl-2-oxopentanoate + H(+) + NADH => (R)-2-hydroxy-4-methylpentanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685290", "l": "SFTPD gene produces SFTPD protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700175", "l": "Active ALK phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69286", "l": "a 17-oxo steroid + H(+) + NADPH => a 17beta-hydroxy steroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61646", "l": "2 Fe(III)-[cytochrome b5] + H2O + L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24138", "l": "a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+) => 3'-phosphoadenylyl sulfate + a primary amine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418850", "l": "Activation of Cdc42 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964773", "l": "OXGR1 binds 2OG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222093", "l": "BRD7 binds TP53 and EP300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44468", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33037", "l": "2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43648", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008692", "l": "IL37(?-218) binds SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60644", "l": "3'-phosphoadenylyl sulfate + androsterone = adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202726", "l": "F11R dimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031868", "l": "prostaglandin F2-alpha receptor binding", "d": ["Binding to a prostaglandin F2-alpha receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045294", "l": "alpha-catenin binding", "d": ["Binding to catenin complex alpha subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12573", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69143", "l": "N-(4-aminobutyl)-3-aminopropanal <=> acrolein + putrescine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57510", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + staphylopine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74254", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76466", "l": "CYP4A11 12-hydroxylates DDCX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204485", "l": "Basigin binds CyPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12973", "l": "AMP + ATP = 2 ADP", "d": [], "t": []}, {"i": "EC:2.7.4.3", "l": "\"adenylate kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018121", "l": "NAD(P)-asparagine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14475", "l": "a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH => a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20900", "l": "H(+) + H2O + N-benzyloxycarbonylglycine = benzyl alcohol + CO2 + glycine", "d": [], "t": []}, {"i": "EC:3.5.1.58", "l": "\"N-benzyloxycarbonylglycine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58922", "l": "(+)-medicarpin + H2O => (3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047657", "l": "alpha-1,3-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21167", "l": "a carboxylic ester + H2O <=> a carboxylate + an alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11814", "l": "formaldehyde + H(+) + H2O2 + hydrogen sulfide => H2O + methanethiol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42404", "l": "H2O + lactose 6-phosphate = beta-D-glucose + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132060", "l": "Formation of C5b:C6:C7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.135", "l": "\"1-hydroxy-2-naphthoate hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24433", "l": "H2O + oxaloacetate => acetate + H(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35787", "l": "paromamine + UDP-alpha-D-kanosamine = H(+) + kanamycin C + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357483", "l": "RAC1 binds PAK1-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390846", "l": "D2D3,4 bind to DA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67874", "l": "3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46512", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}, {"i": "EC:1.14.18.7", "l": "\"dihydroceramide fatty acyl 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48971", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 <=> [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17509", "l": "H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55439", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20119", "l": "ADP + H(+) + L-rhamnulose 1-phosphate => ATP + L-rhamnulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654603", "l": "Activated FGFR2 binds FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59661", "l": "D-cellotetraose + O2 => D-cellotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65795", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102832", "l": "verbascose galactinol:ajugose galactosyltransferase activity", "d": ["Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol = ajugose + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44771", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132206", "l": "MASPs activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204549", "l": "Caveolin-1 binds Basigin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694522", "l": "Inner coat assembly and cargo binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16924", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432067", "l": "Aquaporin-4 passively transports water out of cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055053", "l": "mannose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50044", "l": "an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674430", "l": "PDGFR mutants bind type II TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67271", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate <=> sch 210972", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66719", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21626", "l": "FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538904", "l": "Phosphorylated PER binds to CLK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102317", "l": "4-methylaminobutyrate oxidase (demethylating) activity", "d": ["Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O = gamma-aminobutyric acid + formaldehyde + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41817", "l": "a ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110244", "l": "Excision of FapyG by OGG1 glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956659", "l": "ABL1 phosphorylates YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0043023", "l": "ribosomal large subunit binding", "d": ["Binding to a large ribosomal subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18189", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.21", "l": "\"starch synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47036", "l": "uridine in 5S rRNA = pseudouridine in 5S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047011", "l": "2-dehydropantolactone reductase (A-specific) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098606", "l": "selenocystathionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77501", "l": "(2S)-2-hydroxy-3-phenylpropanenitrile => 2-phenylacetaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42751", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63830", "l": "pyruvate + vanillylamine => L-alanine + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15261", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654399", "l": "Activated FGFR2 binds FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35517", "l": "CoA + salvianin => 4'''-demalonylsalvianin + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56363", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 <=> 13-dihydrocarminomycin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69150", "l": "H2O2 + NH4(+) + spermine monoaldehyde => H2O + O2 + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.340966656807453", "identifiers": [{"i": "GO:0016879", "l": "ligase activity, forming carbon-nitrogen bonds", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.3.-.-", "l": "\"Forming carbon-nitrogen bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50025", "l": "dodecanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24270", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH => 2,6-dioxo-6-phenylhexanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21080", "l": "ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.6", "l": "\"methionine adenosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755258", "l": "DDX58 binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62920", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol = 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420265", "l": "AMY1-3 bind IAPP(34-70) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76810", "l": "(S)-isoleucinol + H2O + NAD(+) <=> (3S)-1-hydroxy-3-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417820", "l": "P2Y9 receptor can bind to LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708866", "l": "pro-F2R binds vorapaxar (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31555", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA = (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": [], "t": []}, {"i": "EC:2.3.1.247", "l": "\"3-keto-5-aminohexanoate cleavage enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950634", "l": "Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047965", "l": "glycoprotein O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28790", "l": "4-hydroxy-L-threonine + ATP <=> 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.10", "l": "\"pectin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022734", "l": "MECP2 binds FKBP5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193068", "l": "CYP17A1 17-hydroxylates PREG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791235", "l": "GADD45A binds AURKA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72320", "l": "n chloride(in) + urate(out) => n chloride(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791387", "l": "TP53 binds the ARID3A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12463", "l": "(S)-malate <=> fumarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662619", "l": "MT1H binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11581", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23510", "l": "(7R)-7-aminocephalosporanate + glutarate => (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28309", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15465", "l": "ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.36", "l": "\"aldose-1-phosphate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21300", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.8", "l": "\"cerebroside-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018826", "l": "RHOT2 hydrolyzes GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21937", "l": "carbamoyl phosphate + putrescine => H(+) + N-carbamoylputrescine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112120", "l": "Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018662", "l": "phenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848338", "l": "PNPLA4 hydrolyzes TAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61642", "l": "benzoyl-CoA + CO2 => H(+) + isophthalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19280", "l": "ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29462", "l": "beta-alanine(in) + H(+)(in) <=> beta-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093329", "l": "EFNBs bind SDCBP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46844", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33441", "l": "glyoxylate + H(+) + H2O2 => glyoxal + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11270", "l": "H(+) + hydrogen sulfide + NH4(+) + pyruvate => D-cysteine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16697", "l": "A + H2O + quinaldate = AH2 + kynurenate", "d": [], "t": []}, {"i": "EC:1.3.99.18", "l": "\"quinaldate 4-oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801101", "l": "RABGGTA binds RABGGTB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30341", "l": "CO2 + tryptamine => H(+) + L-tryptophan", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34573", "l": "H(+) + NADPH + presqualene diphosphate => C30 botryococcene + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296421", "l": "NLRP3 oligomerizes via NACHT domains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49686", "l": "benzene-1,2,4-triol + H2O + NAD(+) => H(+) + NADH + O2 + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781021", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22692", "l": "3-hydroxybenzoate + H(+) + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.24", "l": "\"3-hydroxybenzoate 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.30", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211948", "l": "CYP3A4 can N-demethylate loperamide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176517", "l": "SULTs transfer (SO4)2- group to PREG (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76911", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NAD(+) = 3-methylcyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35982", "l": "dimethylallyl diphosphate + verruculogen <=> diphosphate + fumitremorgin A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30375", "l": "(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.79", "l": "\"thujopsene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21514", "l": "2-dehydro-3-deoxy-L-galactonate => 3,6-anhydro-L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797810", "l": "PTPRD binds IL1RAPL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12639", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59841", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37880", "l": "methyl aklanonate => aklaviketone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956684", "l": "ITCH polyubiquitinates TP73 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67121", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26336", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O <=> 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77337", "l": "alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP + H(+) => [3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49126", "l": "H2O + NADP(+) + protoviolaceinate => H(+) + NADPH + O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.73", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008670", "l": "2,4-dienoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791235", "l": "GADD45A binds AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60254", "l": "acryloyl-CoA + CO2 + NADPH => (S)-methylmalonyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770145", "l": "Formation of the Spliceosomal Bact complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29400", "l": "H2O + ITP => diphosphate + H(+) + IMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56814", "l": "4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004098", "l": "cerebroside-sulfatase activity", "d": ["Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66573", "l": "2-naphthol + 3'-phosphoadenylyl sulfate => 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21783", "l": "A + cyclohexanone <=> AH2 + cyclohex-2-enone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37934", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.7", "l": "\"heparin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140741", "l": "WNT5A binds FZD and ROR receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16368", "l": "digallate + H2O <=> 2 3,4,5-trihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37495", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53197", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004361", "l": "glutaryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12397", "l": "dTDP-D-galactose + H2O + 2 NADP(+) => dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63684", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP = (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64094", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15623", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10783", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333051", "l": "RPA1 binds HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55857", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34982", "l": "H(+)(in) <=> H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53894", "l": "a prenal + H2O2 + L-cysteine => an S-prenyl-L-cysteine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69482", "l": "beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71653", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide => a thymidine in DNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426032", "l": "DAG is metabolized by DAGL to 2-AG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15014", "l": "3alpha(S)-strictosidine + H2O => secologanin + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42370", "l": "H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53518", "l": "(11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65445", "l": "butanoyl-CoA + hexan-1-ol => CoA + hexyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23872", "l": "(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102121", "l": "ceramidase activity", "d": ["Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.4", "l": "\"ribonuclease H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74712", "l": "Dissociation of IRS-P from insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031762", "l": "follicle-stimulating hormone receptor binding", "d": ["Binding to a follicle-stimulating hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194678", "l": "CYP51A1 demethylates LNSOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36312", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47348", "l": "a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15009", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.3", "l": "\"dihydrofolate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008996", "l": "ribonuclease G activity", "d": ["Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952069", "l": "HDAC4 deacetylates RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67672", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66038", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30126", "l": "H2O + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.44", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32120", "l": "GDP-valienol + validamine 7-phosphate => GDP + H(+) + validoxylamine A 7'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63636", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035598", "l": "N6-threonylcarbomyladenosine methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)."], "t": []}, {"i": "REACT:R-HSA-6786571", "l": "CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622310", "l": "Activated NOD1 oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70975", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29272", "l": "a menaquinol + H(+) + trimethylamine N-oxide => a menaquinone + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.61", "l": "\"kexin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112396", "l": "Separation of elongating transcript from template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30760", "l": "5-methylcytosine + H(+) + H2O => NH4(+) + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63292", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66387", "l": "(2E,6E,10E,14E)-geranylfarnesol <=> scalar-17(25)-en-19-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37150", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72506", "l": "glutarate(in) + prostaglandin F2alpha(out) <=> glutarate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008043", "l": "MAPK8 phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799466", "l": "TP53I3 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1067659", "l": "Assembly of hexameric IL-6 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858346", "l": "AMHR2 binds AMH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36763", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868236", "l": "BAR domain proteins recruit dynamin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30701", "l": "3-oxopropanoate + L-glutamate => 2-oxoglutarate + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63118", "l": "nitrate => peroxynitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70903", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928604", "l": "SFKs phosphorylate VAV2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54059", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-hedycaryol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130504", "l": "Cleavage of lip22 to lip10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61210", "l": "H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein] => 8-nitro-cGMP + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36928", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14523", "l": "(2E)-geranial + H(+) + NADPH => (2E)-geraniol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34067", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate = diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": [], "t": []}, {"i": "EC:2.4.2.45", "l": "\"decaprenyl-phosphate phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362422", "l": "Hh-Np binds to DISP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0010484", "l": "histone H3 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59593", "l": "ATP + beta-alanine + L-arginine => ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16744", "l": "a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0008519", "l": "ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33685", "l": "3-oxoeicosasphinganine + CO2 + CoA => H(+) + L-serine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018748", "l": "iprodione amidohydrolase activity", "d": ["Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48028", "l": "H2O + triacetin = acetate + diacetylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16623", "l": "H2O2 + sanguinarine => dihydrosanguinarine + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51001", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine => [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44955", "l": "(2E)-octenoyl-CoA + H(+) + NADPH <=> NADP(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218815", "l": "p-6Y-VEGFR2 binds NCK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29104", "l": "5 H(+)(in) + menaquinone-8 + NADH => 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760402", "l": "ILF3 binds HOXC8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634834", "l": "ACHEIs bind ACHE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047754", "l": "choline sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199929", "l": "ERK5 activates the transcription factor MEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613497", "l": "Unwinding DNA for the nascent transcript (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77359", "l": "2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39258", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46720", "l": "(3R)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416929", "l": "PTGFR binds PGF2a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62755", "l": "H2O + pravastatin lactone <=> (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61183", "l": "quercetin + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45148", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40414", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21570", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose => beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36511", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47029", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44352", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide C + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354097", "l": "Activation of Talin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14328", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose <=> daphnin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396370", "l": "VTN binds collagens II, III and V (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44197", "l": "3-methylundecanoate + ATP + CoA => 3-methylundecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49221", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP => CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177920", "l": "Binding of GRB2 to GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944104", "l": "PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098882", "l": "structural constituent of presynaptic active zone", "d": ["The action of a molecule that contributes to the structural integrity of a presynaptic active zone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41072", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63677", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74711", "l": "Phosphorylation of IRS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22272", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.121", "l": "\"protopanaxadiol 6-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40931", "l": "2-oxoglutarate + L-ornithine + O2 = (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72747", "l": "leukotriene E4(out) = leukotriene E4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388831", "l": "Phosphorylation of CD28 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417890", "l": "P2Y5 receptor can bind to LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20022", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 => amidinoproclavaminate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54429", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O => ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864577", "l": "TFAP2C translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042898", "l": "fosmidomycin transmembrane transporter activity", "d": ["Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010681", "l": "PKC phosphorylates ROBO3.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15996", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65919", "l": "L-kynurenine + pyruvate <=> H2O + kynurenate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769394", "l": "AKT phosphorylates CBY1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51216", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103008", "l": "4-chloro-2-methylphenoxyacetate oxygenase activity", "d": ["Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632738", "l": "DDIT4 binds 14-3-3 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047964", "l": "glyoxylate reductase (NAD+) activity", "d": ["Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12865", "l": "1-methyladenosine + H2O = 1-methyladenine + D-ribose", "d": [], "t": []}, {"i": "EC:3.2.2.13", "l": "\"1-methyladenosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0003870", "l": "5-aminolevulinate synthase activity", "d": ["Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60271", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27444", "l": "NAD(+) + xylitol <=> D-xylose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682967", "l": "WHSC1 binds DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202222", "l": "Phosphorylation of PKC theta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879562", "l": "SLCO2B1 has a narrow substrate specificity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690740", "l": "CD22 binds B-cell receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15933", "l": "(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31411", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203700", "l": "eNOS translocation from Golgi to Caveolae (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31244", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) => (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013159", "l": "CDC42 GEFs activate CDC42 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12204", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37724", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004587", "l": "ornithine aminotransferase activity", "d": ["Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72409", "l": "H(+)(out) + Li(+)(in) => H(+)(in) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54265", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831057", "l": "Expression of SALL1 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879674", "l": "CD97 binds CD55 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74955", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005026", "l": "transforming growth factor beta receptor activity, type II", "d": ["Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor."], "t": []}, {"i": "REACT:R-HSA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018071", "l": "NAD(P)-cysteine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977375", "l": "CR1 binds C3bBb/C4bC2a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14714", "l": "A + keto-L-sorbose => 5-dehydro-D-fructose + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678925", "l": "NR3C1 binds NR3C1 agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601976", "l": "Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52931", "l": "3',3'-c-di-GMP + 2 H2O <=> 2 GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000120", "l": "CBLIF binds RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102224", "l": "GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity", "d": ["Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71491", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20711", "l": "ATP + erythritol <=> ADP + D-erythritol 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0008376", "l": "acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70703", "l": "D-cycloserine(in) + H(+)(in) = D-cycloserine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837337", "l": "DCAKD phosphorylates DP-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090591", "l": "protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55603", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134914", "l": "Beta-catenin migrates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58457", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75071", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) = chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112727", "l": "Serine phosphorylation of STATs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75960", "l": "(S)-scoulerine + 2-oxoglutarate + O2 => (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21431", "l": "(2R)-3-sulfolactate <=> H(+) + pyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222526", "l": "AhpC reduces peroxidated lipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48567", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O <=> D-ribose 5-phosphate + trans-zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173739", "l": "Spontaneous hydrolysis of C3 thioester (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65215", "l": "(2E)-dodecenoyl-CoA + H2O <=> (2E)-dodecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033130", "l": "acetylcholine receptor binding", "d": ["Binding to an acetylcholine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20327", "l": "N-acetoxy-4-aminobiphenyl => N-hydroxy-4-acetylaminobiphenyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41849", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH => NADP(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52683", "l": "acetyl-CoA + L-alpha-phenylglycine <=> CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52862", "l": "a short-chain fatty acyl-CoA + AMP + diphosphate => a short-chain fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12654", "l": "(S)-malate + NAD(+) => CO2 + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61282", "l": "H2O2 + NH4(+) + succinate semialdehyde => 4-aminobutanoate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218821", "l": "PDK1 phosphorylates PKC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49560", "l": "D-sedoheptulose 7-phosphate = (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.154", "l": "\"demethyl-4-deoxygadusol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990424", "l": "protein arginine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75466", "l": "choline(out) + n H(+)(in) <=> choline(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704248", "l": "CHRM4 binds CHRM4 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27655", "l": "2-oxobutanoate + H(+) + pyruvate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39454", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52611", "l": "2-hydroxybutanoate + NADP(+) <=> 2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446634", "l": "IRAK4 is activated by autophosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050302", "l": "indole-3-acetaldehyde oxidase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21107", "l": "AH2 + cholesterol + O2 <=> 25-hydroxycholesterol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28469", "l": "pyridoxamine(in) <=> pyridoxamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74131", "l": "malvidin + UDP-alpha-D-galactose = H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59670", "l": "D-cellohexaono-1,5-lactone + H2O2 => D-cellohexaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73827", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52507", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39402", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420243", "l": "GHRH receptor binds GHRH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53884", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19437", "l": "nicotinate + UDP-alpha-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.196", "l": "\"nicotinate glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58177", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41473", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25451", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-guaia-6,9-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22420", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) = 2 H(+) + maleylacetate + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.61", "l": "\"4-hydroxymuconic-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39123", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14768", "l": "coelenterazine h + O2 <=> CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004656", "l": "procollagen-proline 4-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16239", "l": "[protein]-peptidylproline (omega=0) => [protein]-peptidylproline (omega=180)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18118", "l": "L-tyrosine + O2 => H2O + L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69795", "l": "D-aspartyl-tRNA(Asp) + H2O = D-aspartate + H(+) + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296477", "l": "Defective AMN does not transport GIF:Cbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21014", "l": "4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010872", "l": "SLIT2 binds Dystroglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40890", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29809", "l": "ADP + H(+) + L-leucine(in) + phosphate => ATP + H2O + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606602", "l": "ASAH1 hydrolyzes ceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55470", "l": "11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68614", "l": "NADP(+) + prostaglandin F1 => H(+) + NADPH + prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37490", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35445", "l": "an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31656", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77279", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43091", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine <=> 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250220", "l": "Homodimerization of ERBB4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18641", "l": "a menaquinone + H2 = a menaquinol", "d": [], "t": []}, {"i": "EC:1.12.5.1", "l": "\"hydrogen:quinone oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043823", "l": "spheroidene monooxygenase activity", "d": ["Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050550", "l": "pinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate. This reaction can produce both alpha-pinene and beta-pinene."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60283", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350158", "l": "LGMN degrades GC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015277", "l": "kainate selective glutamate receptor activity", "d": ["An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64906", "l": "GMP + 2 H(+) + 2 phosphate => GTP + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22263", "l": "H2O + triacetate lactone <=> H(+) + triacetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70911", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190260", "l": "FGFR2b binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23429", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.923108426128749", "identifiers": [{"i": "GO:0140104", "l": "molecular carrier activity", "d": ["Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45549", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48175", "l": "a ganglioside GM2 + H2O <=> a ganglioside GA2 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204485", "l": "Basigin binds CyPA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32890", "l": "all-trans-beta-carotene + O2 <=> 2 all-trans-retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.34", "l": "\"6,7-dihydropteridine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.395", "l": "\"3alpha-hydroxybile acid CoA 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66773", "l": "ATP + H2O + uroporphyrin I(in) => ADP + H(+) + phosphate + uroporphyrin I(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730862", "l": "Autophosphorylation of LYN kinase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37060", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate => AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50082", "l": "ADP + H(+) + phosphate + taurodeoxycholate(out) => ATP + H2O + taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873927", "l": "Release of STAT1 dimer from active receptor unit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24048", "l": "phosphate + sucrose = alpha-D-glucose 1-phosphate + D-fructose", "d": [], "t": []}, {"i": "EC:2.4.1.7", "l": "\"sucrose phosphorylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20612", "l": "2-dehydro-3-deoxy-D-arabinonate <=> glycolaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168848", "l": "tBID binds to inactive BAK protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56327", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] <=> 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690886", "l": "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34470", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + valerena-4,7(11)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654651", "l": "Activated FGFR4 binds FRS3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13346", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31858", "l": "(S)-2,3-epoxysqualene <=> achilleol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211247", "l": "Cleavage of DNA by DFF40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690740", "l": "CD22 binds B-cell receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031851", "l": "kappa-type opioid receptor binding", "d": ["Binding to a kappa-type opioid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842115", "l": "PSAP(195-273) dimer binds PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50828", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725206", "l": "IgE binds FCERI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73204", "l": "D-glucose(out) + H(+)(in) => D-glucose(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36416", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28134", "l": "(2S)-hesperidin + H2O = (2S)-hesperetin + rutinose", "d": [], "t": []}, {"i": "EC:3.2.1.168", "l": "\"hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37225", "l": "1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106243", "l": "syn-isopimara-7,15-diene synthase activity", "d": ["Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene."], "t": []}, {"i": "RHEA:62188", "l": "9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48529", "l": "a ganglioside GP1c (d18:1(4E)) + H2O => a ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51670", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone => 2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44117", "l": "eicosan-1-ol + hexadecanoyl-CoA => CoA + eicosanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44461", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48881", "l": "a quinone + CO + H2O => a quinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180007", "l": "RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36893", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74580", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] => N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46092", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32363", "l": "L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate", "d": [], "t": []}, {"i": "EC:1.1.3.8", "l": "\"L-gulonolactone oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.-.-", "l": "\"Oxidizing metal ions\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36110", "l": "gibberellin A4 + S-adenosyl-L-methionine <=> O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73158", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) <=> adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41196", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093329", "l": "EFNBs bind SDCBP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17320", "l": "chlorophyllide a + H(+) + phytyl diphosphate <=> chlorophyll a + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48959", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40542", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55522", "l": "3 diphosphate + nerylneryl diphosphate => dimethylallyl diphosphate + 3 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27925", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23966", "l": "(E)-ferulate + 2 H(+) + NADPH => (E)-coniferaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71189", "l": "AFMID hydrolyses NFK to L-KYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761344", "l": "USP18 binds IKBKG within IKK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199093", "l": "CXADR binds to AMICA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30783", "l": "D-glyceraldehyde + H2O + NAD(+) = (R)-glycerate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354097", "l": "Activation of Talin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211904", "l": "CYP4F12 18-hydroxylates ARA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19364", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2E,6E)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20852", "l": "ATP + H(+)(in) + H2O = ADP + 2 H(+)(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.1.2.1", "l": "\"P-type H(+)-exporting transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172666", "l": "RB1 binds condensin II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18473", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": [], "t": []}, {"i": "EC:2.4.2.17", "l": "\"ATP phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16472", "l": "(R)-2-benzylsuccinate + succinyl-CoA <=> (R)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0003724", "l": "RNA helicase activity", "d": ["Unwinding of an RNA helix, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27552", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate => di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0019156", "l": "isoamylase activity", "d": ["Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75261", "l": "3'-dehydroisoorientin + H2O2 => isoorientin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57021", "l": "apulose + ATP => ADP + apulose 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48677", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36066", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + kunzeaol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649393", "l": "ERBB2 KD mutants bind trastuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.71", "l": "\"endothelin-converting enzyme 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102237", "l": "ATP:farnesol kinase activity", "d": ["Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1878002", "l": "XYLTs transfer Xyl to core protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10525", "l": "2-oxoglutarate + H(+) => CO2 + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981353", "l": "RASA1 stimulates RAS GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69847", "l": "a 5,6-dihydrouridine in RNA + NADP(+) = a uridine in RNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69529", "l": "chorismate + H2O + 2 L-glutamine => 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54202", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018807", "l": "6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21179", "l": "L-idonate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43503", "l": "beta-D-glucuronate + NAD(+) <=> D-glucaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74861", "l": "H2O + norsalsolinol => dopamine + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42707", "l": "hercynine + L-cysteine + O2 <=> H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63262", "l": "4-pyridoxate + NAD(+) => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40229", "l": "A47934 + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + desulfo-A47934", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39041", "l": "a dicarboxylate + 2 H(+) + NADH => an omega-oxo fatty acid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.25", "l": "\"cucumisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53957", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) => 4-aminobutanoyl-[BtrI ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.47", "l": "\"8-amino-7-oxononanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707516", "l": "FeHM dissociates from MetHb (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392749", "l": "Transport of L1 into endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.122", "l": "\"transmembrane protease serine 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299338", "l": "Activation of TRESK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "56.414080930423076", "identifiers": [{"i": "GO:0005249", "l": "voltage-gated potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28318", "l": "scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45398", "l": "(9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66310", "l": "an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0019003", "l": "GDP binding", "d": ["Binding to GDP, guanosine 5'-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0005518", "l": "collagen binding", "d": ["Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030597", "l": "RNA glycosylase activity", "d": ["Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450422", "l": "KSRP recruits RNA degradation activities (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67893", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine => 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.12", "l": "\"N-acetylgalactosamine-4-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205238", "l": "SHP2 interacts with p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55770", "l": "all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-retinoate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66659", "l": "Cu(2+)(out) + L-ascorbate(in) <=> Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.249098858391747", "identifiers": [{"i": "GO:0034212", "l": "peptide N-acetyltransferase activity", "d": ["Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950342", "l": "EBI3:CANX binds IL27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54697", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681987", "l": "LC3 is cleaved by ATG4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46152", "l": "15-cis-phytoene + a plastoquinone = 15,9'-di-cis-phytofluene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17884", "l": "H2O + N-sulfo-D-glucosamine <=> D-glucosamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35401", "l": "beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+) => 1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70401", "l": "CoA + H(+) + N-tetracosanoyl-3-oxosphinganine => 3-oxosphinganine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77549", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59538", "l": "(2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55113", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784861", "l": "HSPG binds LPL dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47114", "l": "glycochenodeoxycholate + H2O => chenodeoxycholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824222", "l": "HES7 binds the HES7 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20189", "l": "5,6-dihydrouracil + NAD(+) = H(+) + NADH + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24059", "l": "a myo-inositol phosphate + H2O <=> myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848395", "l": "IL18:IL18R1 binds IL18RAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42363", "l": "D-allulose <=> keto-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621399", "l": "SCD5 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74258", "l": "XDH oxidizes xanthine to form urate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0017154", "l": "semaphorin receptor activity", "d": ["Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21038", "l": "acetoacetyl-CoA + CoA => 2 acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9650165", "l": "ASIC trimers bind H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71730", "l": "citrate(out) + fumarate(in) <=> citrate(in) + fumarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042806", "l": "fucose binding", "d": ["Binding to fucose, the pentose 6-deoxygalactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25294", "l": "acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40565", "l": "dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+) => dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52092", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71844", "l": "tauroursodeoxycholate(out) => tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39063", "l": "NADP(+) + scyllo-inositol = H(+) + NADPH + scyllo-inosose", "d": [], "t": []}, {"i": "EC:1.1.1.371", "l": "\"scyllo-inositol 2-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41635", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202241", "l": "Recruitment of SLP-76 to Gads (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56501", "l": "(R)-3,5-bisphosphomevalonate + H(+) => CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678981", "l": "TLR9 processing at neutral pH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198813", "l": "GSTO dimers reduce DeHA to AscH- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50309", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46973", "l": "A + dihydrobisanhydrobacterioruberin => AH2 + bisanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102071", "l": "9,10-epoxy-18-hydroxystearate hydrolase activity", "d": ["Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O = 9,10,18-trihydroxystearate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64782", "l": "2-aminoprop-2-enoate + benzylthiol => S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981892", "l": "Active G alpha (z) binds RGS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018619", "l": "benzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene + H+ + NADH + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254291", "l": "ERBB4s80 binds STAT5A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46952", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.17.1.11", "l": "\"formate dehydrogenase (NAD(+), ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61630", "l": "1-piperideine + H2O => 5-aminopentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48137", "l": "a ganglioside GM3 + H2O => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20324", "l": "L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174097", "l": "Association of Emi1 with Cdh1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49199", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13903", "l": "N-(hydroxymethyl)urea + NH4(+) => H2O + N-(aminomethyl)urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38412", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004745", "l": "NAD-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16334", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] => diphosphate + holo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001571", "l": "non-tyrosine kinase fibroblast growth factor receptor activity", "d": ["Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40964", "l": "4 2-aminophenol + 3 O2 => 2 2-aminophenoxazin-3-one + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350058", "l": "Formation of CSL NCOR corepressor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39782", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35969", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12895", "l": "prostaglandin E2 => prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51579", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + phlorizin + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036384", "l": "CDP phosphatase activity", "d": ["Catalysis of the reaction: CDP + H2O = CMP + phosphate."], "t": []}, {"i": "RHEA:64880", "l": "CDP + H2O = CMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12668", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA <=> an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446322", "l": "PARVA associates with Paxillin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10683", "l": "L-proline <=> D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64929", "l": "dADP + H2O => dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44541", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612246", "l": "ERBB4s80 binds the APOE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33835", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42931", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13703", "l": "CoA + O-acetyl-L-homoserine => acetyl-CoA + L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77517", "l": "(2S)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile => 3-methoxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.1", "l": "\"deoxyribonuclease I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750666", "l": "ALB binds ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418549", "l": "PKG1 phosphorylates BK channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67907", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] <=> 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14224", "l": "H2O + monomethyl sulfate <=> H(+) + methanol + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57587", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66582", "l": "adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+) => 3'-phosphoadenylyl sulfate + bisphenol A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21719", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46959", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69082", "l": "3,4-dihydroxyphenylacetate + 2 H(+) + NADH => 3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.-", "l": "\"Serine-type carboxypeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672978", "l": "RAF phosphorylates MAP2K dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28801", "l": "glycine + L-proline => H2O + L-prolinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45669", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42599", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213017", "l": "Auto-ubiquitination of TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68062", "l": "a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140481", "l": "ABC-type iron-sulfur cluster transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)."], "t": []}, {"i": "TCDB:3.A.1.210.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18897", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine", "d": [], "t": []}, {"i": "EC:1.21.99.3", "l": "\"thyroxine 5-deiodinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68216", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21526", "l": "(2S)-2-isopropylmalate + CoA + H(+) => 3-methyl-2-oxobutanoate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30816", "l": "beta-nicotinamide D-ribonucleotide + H2O => beta-nicotinamide D-riboside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16954", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine => L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28565", "l": "D-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34964", "l": "Na(+)(in) => Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0004738", "l": "pyruvate dehydrogenase activity", "d": ["Catalysis of the oxidative decarboxylation of pyruvate."], "t": []}, {"i": "REACT:R-HSA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139920", "l": "Translocation of tBID to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034952", "l": "malonate semialdehyde decarboxylase activity", "d": ["Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987120", "l": "JAK1 binds IFNLR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11757", "l": "ATP + biotin + L-lysyl-[protein] => AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483087", "l": "PI is exchanged with PC by PITPNB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694525", "l": "M protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018808", "l": "RAC3 binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18047", "l": "alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+) => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62376", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O = (S)-lactate + H(+) + pyruvate", "d": [], "t": []}, {"i": "EC:3.7.1.26", "l": "\"2,4-didehydro-3-deoxy-L-rhamnonate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76752", "l": "5-hydroxydodecanoate + H(+) => delta-dodecalactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114284", "l": "Release of Cytochrome c from mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209130", "l": "Full-length SPZ dimer is cleaved by EA/SPE serine protease (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.155", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54655", "l": "peregrinol diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59512", "l": "acetylsalicylate + L-seryl-[protein] = O-acetyl-L-seryl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48024", "l": "1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11293", "l": "2 H(+) + O2 + rifamycin B => H2O2 + rifamycin O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.77", "l": "\"alkyl sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980051", "l": "DLL4 binds NOTCH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20442", "l": "L-cysteine + O2 => 3-sulfino-L-alanine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564169", "l": "Collagen type VIII degradation by MMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21818", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => a D-alpha-amino acid + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44509", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45299", "l": "a sphingosylphosphocholine + H2O <=> a sphingoid base + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34532", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68953", "l": "isoscopoletin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62216", "l": "isoepoxydon + NADP(+) = H(+) + NADPH + phyllostine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395764", "l": "atREs binds to nascent CM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75276", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20304", "l": "ATP + L-arginine + tRNA(Arg) <=> AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45479", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40424", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19043", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10853", "l": "dimethylallyl diphosphate + leachianone G => diphosphate + sophoraflavanone G", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31449", "l": "5-aminopentanoate + CO2 + H2O => 6-amino-2-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197690", "l": "Detachment of WASP/WAVE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102895", "l": "colneleate synthase activity", "d": ["Catalysis of the reaction: 9(S)-HPODE = colneleate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938987", "l": "BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592236", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51846", "l": "(9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40655", "l": "(R)-malate + succinyl-CoA = (R)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69878", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75038", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate <=> 1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14711", "l": "a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(5)-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22158", "l": "GMP + H(+) + phosphate => GDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33632", "l": "ATP + CoA + octanoate => AMP + diphosphate + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690494", "l": "RHOB translocates to the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29907", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49495", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016152", "l": "mercury (II) reductase activity", "d": ["Catalysis of the reaction: H+ + Hg + NADP+ = Hg2+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62032", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.59", "l": "\"protein geranylgeranyltransferase type I\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222412", "l": "lpdC dimer reactivates dlaT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047395", "l": "glycerophosphoinositol glycerophosphodiesterase activity", "d": ["Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = sn-glycerol 3-phosphate + myo-inositol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0070546", "l": "L-phenylalanine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607043", "l": "factor VIIIa associates with cell membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39369", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34642", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + neopentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19281", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": [], "t": []}, {"i": "EC:1.14.14.141", "l": "\"psoralen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60433", "l": "A + cannabigerolate => AH2 + cannabichromenate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10967", "l": "ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016314", "l": "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35232", "l": "rifampicin(in) => rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839073", "l": "HTRA2 binds NDUFA13 (GRIM-19) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11223", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17920", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) <=> [Glu(-Cys)](n+1)-Gly + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37820", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72556", "l": "estrone 3-sulfate(out) + propanoate(in) => estrone 3-sulfate(in) + propanoate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63127", "l": "H2O + N-octadecanoyl ethanolamine <=> ethanolamine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20714", "l": "(8S)-8-amino-7-oxononanoate + CO2 + CoA => 6-carboxyhexanoyl-CoA + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391941", "l": "BLT receptors can bind LTB4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44752", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75832", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299484", "l": "TIMM8:TIMM13 chaperones hydrophobic proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023348", "l": "MECP2 binds DLL1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60636", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine = choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45605", "l": "D-glucaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213192", "l": "Hemidesmosome formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070406", "l": "glutamine binding", "d": ["Binding to glutamine, 2,5-diamino-5-oxopentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53509", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40776", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O => D-alpha-phenylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18084", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + pentalenene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851919", "l": "Activated MET binds GAB1 and GRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34947", "l": "(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656891", "l": "OPN1SW binds 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653886", "l": "B4GALT1 binds LALBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31203", "l": "acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69775", "l": "(2E,6E)-farnesyl diphosphate = beta-ylangene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56726", "l": "4-hydroxy-all-trans-beta-carotene + A + H2O => AH2 + all-trans-beta-carotene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52136", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.70", "l": "\"guaosine-5'-diphospho-5'-[DNA] diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0008422", "l": "beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080097", "l": "L-tryptophan:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111238", "l": "Formation of ADAR2  homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34545", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70965", "l": "3-phenylpyruvate + H2O2 + NH4(+) => D-phenylalanine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53644", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.163", "l": "\"(+)-corvol ether B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848250", "l": "ACBD6 binds LCFA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76031", "l": "2 H2O2 => O2 + 2 H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31841", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67956", "l": "(S)-2-chloropropanoate + H2O = (R)-lactate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66886", "l": "11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702607", "l": "pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69066", "l": "H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54723", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44485", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33477", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732629", "l": "PPARG binds PPARG agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72797", "l": "bilirubin-bisglucuronoside(in) => bilirubin-bisglucuronoside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982775", "l": "Growth hormone receptor dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034796", "l": "adipate-CoA ligase activity", "d": ["Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-921155", "l": "p-STAT5 dissociates from the receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14315", "l": "1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine => 2-iodophenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189439", "l": "ALAD condenses 2 dALAs to form PBG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9833777", "l": "PKR binds activating host RNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560802", "l": "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873929", "l": "Casein kinase II phosphorylates STARD10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48612", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}, {"i": "EC:2.8.1.11", "l": "\"molybdopterin synthase sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25699", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67277", "l": "H2O + hexanal + NAD(+) => 2 H(+) + hexanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004058", "l": "aromatic-L-amino-acid decarboxylase activity", "d": ["Catalysis of the reaction: L-amino acid + H+ = R-H + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61799", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP <=> AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805061", "l": "CK2 binds FACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28437", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] <=> ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57220", "l": "GTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676268", "l": "Formation of the MLL4 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0050750", "l": "low-density lipoprotein particle receptor binding", "d": ["Binding to a low-density lipoprotein receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671772", "l": "p-T38-PPP1R14A binds MLCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21286", "l": "all-trans-retinal + H(+) + NADH => all-trans-retinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48595", "l": "a quinone + formate + H(+) <=> a quinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376122", "l": "DSCAM/DSCAML1 homodimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67249", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097383", "l": "dIDP phosphatase activity", "d": ["Catalysis of the reaction: dIDP + H2O = dIMP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362437", "l": "C-terminal Hh fragments are bound by lectins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38561", "l": "(R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10007", "l": "benzyl isothiocyanate <=> benzyl thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12670", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67815", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64764", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44886", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => a cardiolipin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31603", "l": "(Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76573", "l": "(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate => 4-deoxy-L-erythro-hex-4-enopyranuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033792", "l": "3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity", "d": ["Catalysis of the reactions: a 3alpha-hydroxy bile acid CoA + NAD+ = a 3-oxo bile acid CoA + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70596", "l": "GOT2 dimer deaminates L-Asp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008839", "l": "BAX gene expression is stimulated by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34638", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + pentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51497", "l": "a sphingoid base + ATP => a sphingoid 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507873", "l": "Aquaporins passively transport urea out of cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52245", "l": "4 H(+) + 4 Mn(2+) + O2 => 2 H2O + 4 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69981", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69944", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44702", "l": "a (2E)-enoyl-CoA + FADH2 => a 2,3-saturated acyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23522", "l": "acetate + propanoyl-CoA => acetyl-CoA + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48593", "l": "a quinone + formate + H(+) => a quinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0017018", "l": "myosin phosphatase activity", "d": ["Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47250", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63417", "l": "2,6-dichlorohydroquinone + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483186", "l": "PC is converted to PS by PTDSS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709547", "l": "ESTG binds ESR2:chaperone complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700984", "l": "TP53 family members stimulate BAX transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73979", "l": "(2E,6E)-farnesyl diphosphate = calarene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18856", "l": "NAD(+) + tartrate <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27541", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75705", "l": "14,15-epoxy-12-hydroxy-(10E)-eicosenoate => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16126", "l": "ATP + D-fructose => ADP + D-fructose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69963", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20921", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 => 3,5-dichlorocatechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35980", "l": "dimethylallyl diphosphate + verruculogen => diphosphate + fumitremorgin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016711", "l": "flavonoid 3'-monooxygenase activity", "d": ["Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961915", "l": "CDC45 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866941", "l": "MID1IP1 binds THRSP (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23247", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59847", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730501", "l": "SARS-CoV-2 3CLpro dimer binds to STING (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10585", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72724", "l": "UDP-alpha-D-xylose(in) + UMP(out) => UDP-alpha-D-xylose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683656", "l": "mRNA4 is translated to protein E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849908", "l": "SALM4 binds flotillin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602458", "l": "Activation of proMMP10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20879", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32946", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679044", "l": "FKBP1A binds sirolimus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199131", "l": "PVR binds CD226 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54843", "l": "H(+) + NADPH + O2 + octan-3-one <=> H2O + NADP(+) + pentyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73313", "l": "L-thyroxine sulfate(in) => L-thyroxine sulfate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220944", "l": "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20352", "l": "H(+) + NADH + O2 + toluene <=> 2-hydroxytoluene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33696", "l": "C20 sphinganine + NADP(+) => 3-oxoeicosasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836404", "l": "p-PKR dimer phosphorylates MAPT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54136", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65354", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660479", "l": "MTF1 dimer:12Zn2+ binds SNCB gene (beta-synuclein) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58229", "l": "L-asparaginyl-[protein] + NAD(+) => H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41854", "l": "3-oxodecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203700", "l": "eNOS translocation from Golgi to Caveolae (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198983", "l": "NKG2D homodimer interacting with ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35212", "l": "dIDP + H2O => dIMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395801", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45624", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine = AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.46", "l": "\"L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42338", "l": "[thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin] => [thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.72", "l": "\"xylan 1,3-beta-xylosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10696", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] = AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}, {"i": "EC:6.2.1.49", "l": "\"long-chain fatty acid adenylyltransferase FadD28\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28551", "l": "acetyl-CoA + anthranilate => CoA + N-acetylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54131", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018804", "l": "RAC3 GEFs activate RAC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76247", "l": "ATP + ergothioneine(out) + H2O = ADP + ergothioneine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59099", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose <=> diglucosyl-enterobactin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56781", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74853", "l": "(R)-salsolinol + H2O => acetaldehyde + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948136", "l": "ULK1 Translocates to the mitochondria (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48718", "l": "13-oxo-(9Z,11E)-octadecadienoate + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989754", "l": "Expression of APOA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31829", "l": "(+)-gamma-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24799", "l": "(S)-2-amino-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688294", "l": "SIRT5 deacetylates Cytochrome C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990482", "l": "sphingolipid alpha-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15709", "l": "kaempferol + UDP-alpha-D-galactose = H(+) + kaempferol 3-O-beta-D-galactoside + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.234", "l": "\"kaempferol 3-O-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.176", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928604", "l": "SFKs phosphorylate VAV2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55077", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) => 3-methylsulfanylpropanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13682", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708275", "l": "PDE4A binds PDE4A inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29430", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) <=> (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0043178", "l": "alcohol binding", "d": ["Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203979", "l": "Coat Assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445700", "l": "Myosin Binds ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51065", "l": "3'-phosphoadenylyl sulfate + lithocholate => adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30517", "l": "H(+) + S-methyl-5'-thioadenosine + thermospermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28048", "l": "CoA + propanoyl phosphate => phosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70277", "l": "D-galactose + sucrose => H2O + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70899", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2423785", "l": "CR:atREs binds apoE and HSPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32430", "l": "(1R,4S)-isodihydrocarvone + A <=> (S)-carvone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19267", "l": "3-dehydrocarnitine + H(+) + NADH => carnitine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34360", "l": "a 1,2-diacylglycerol + H2O => a 2-acylglycerol + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37322", "l": "ATP + glycyl-L-methionine(out) + H2O <=> ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655193", "l": "KIAA0101 double monoubiquitination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16048", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41524", "l": "5 H(+) + 5 malonyl-CoA = 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}, {"i": "EC:2.3.1.233", "l": "\"1,3,6,8-tetrahydroxynaphthalene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50285", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35687", "l": "NADP(+) + tetradecasphinganine = 3-oxotetradecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20221", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-formyltetrahydrofolate + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.3", "l": "\"formate--tetrahydrofolate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976801", "l": "Complement factor I complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49573", "l": "Fe-coproporphyrin III + 2 H(+) => coproporphyrin III + Fe(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614591", "l": "Excess cysteine yields lanthionine and H2S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45574", "l": "[alginate](n) => [(1->4)-beta-D-mannuronosyl](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632958", "l": "PMS2 variants-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761421", "l": "CDH11 associates with catenins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72537", "l": "2 H(+) + NADPH + vanillate => H2O + NADP(+) + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.393", "l": "\"MMP alpha-(1->4)-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433986", "l": "activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the  phospho-IkB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.31", "l": "\"ananain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17293", "l": "2 H(+) + NADH + O2 + precorrin-3A = H2O + NAD(+) + precorrin-3B", "d": [], "t": []}, {"i": "EC:1.14.13.83", "l": "\"precorrin-3B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42709", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22828", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.31", "l": "\"phosphoribosyl-ATP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173723", "l": "C8 binds C5b:C6:C7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042281", "l": "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2167942", "l": "Collagen type XIII ectodomain shedding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36720", "l": "hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-hexacosenoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1454916", "l": "The ABCC family mediates organic anion transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62343", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide C + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654167", "l": "Activated FGFR1 binds PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16255", "l": "H(+) + NADH + phenanthrene-3,4-diol => (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0000978", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10958", "l": "H2O + NADP(+) + trans-2-coumarate => (E)-cinnamate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080007", "l": "S-nitrosoglutathione reductase activity", "d": ["Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41809", "l": "(3R)-hydroxybutanoyl-[ACP] => (2E)-butenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45792", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 = [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24989", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] => calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380949", "l": "AMPK is dephosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23892", "l": "3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.16", "l": "\"beta-nitroacrylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25251", "l": "(2S)-2-acetolactate + CO2 => H(+) + 2 pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.215", "l": "\"arabinogalactan exo alpha-(1,3)-alpha-D-galactosyl-(1->3)-L-arabinofuranosidase (non-reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762345", "l": "PREDN:ALB dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990650", "l": "inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140946", "l": "histone H3K4 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38022", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol <=> 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16961", "l": "epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine", "d": [], "t": []}, {"i": "EC:4.3.2.8", "l": "\"gamma-glutamylamine cyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19875", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate => dehydroepiandrosterone 3-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.112", "l": "\"oxaloacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047630", "l": "ADP-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166015", "l": "Association of LBP with LPS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008913", "l": "lauroyltransferase activity", "d": ["Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432054", "l": "Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53617", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-isoafricanol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332390", "l": "Translocation and activation of PKC alpha in response to WNT signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25163", "l": "2-oxoglutarate + L-ornithine <=> L-glutamate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018674", "l": "(S)-limonene 3-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (1S,6R)-isopiperitenol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19574", "l": "[phosphate](n) + ATP => [phosphate](n+1) + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444100", "l": "PROT mediates L-proline uptake (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60578", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27971", "l": "D-maltotriose + H2O => alpha-D-glucose + D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61567", "l": "a tetracycline + H(+) + NADPH + O2 <=> a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947499", "l": "Exchange of oxygen with sulfur in MoCo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.316", "l": "\"mitomycin 6-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23630", "l": "a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25677", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031403", "l": "lithium ion binding", "d": ["Binding to a lithium ion (Li+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162363", "l": "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863463", "l": "STON2 binds SYT proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0000700", "l": "mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060961", "l": "phospholipase D inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of phospholipase D."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44730", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419645", "l": "Dimerization of LIMK1 by Hsp90 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199112", "l": "CRTAM binds to NECL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694409", "l": "Nucleotide exchange on RAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15769", "l": "adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607744", "l": "MALT1 binds BCL10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25862", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+) => GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40705", "l": "1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39344", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39698", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.301", "l": "\"2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168886", "l": "Hemopexin binds Hemes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202534", "l": "Ubiquitination of NEMO by TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45983", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070854", "l": "myosin VI heavy chain binding", "d": ["Binding to a heavy chain of a myosin VI complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48550", "l": "[phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211959", "l": "CYP3A43 6b-hydroxylates TEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41922", "l": "(3R)-hydroxyoctadecanoyl-[ACP] + NADP(+) => 3-oxooctadecanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014454", "l": "RHOG translocates to the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28413", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015350", "l": "methotrexate transmembrane transporter activity", "d": ["Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62530", "l": "dihydrodigoxin + 2 Fe(III)-[cytochrome c] => digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834897", "l": "Expression of MSX1 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41509", "l": "L-ornithine + NADPH + O2 => H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18450", "l": "A + arsenite + H2O => AH2 + arsenate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66566", "l": "5-histaminyl-L-glutamyl-[protein] + NH4(+) => histamine + L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.64", "l": "\"inosine diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052612", "l": "adonirubin 3-hydroxylase activity", "d": ["Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55156", "l": "a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione", "d": [], "t": []}, {"i": "EC:1.8.5.8", "l": "\"eukaryotic sulfide quinone oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46430", "l": "(25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12334", "l": "ADP + Fe(3+)(in) + H(+) + phosphate => ATP + Fe(3+)(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63042", "l": "H(+) + lovastatin carboxylate => H2O + lovastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168459", "l": "Lyn activates ERK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67618", "l": "8-oxo-GMP + diphosphate + H(+) => 8-oxo-GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710106", "l": "ELANE cleaves GSDMD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76170", "l": "glycyl-L-leucine(out) + 2 H(+)(out) <=> glycyl-L-leucine + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42434", "l": "maleylacetate => 3-hydroxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050490", "l": "1,4-lactonase activity", "d": ["Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474266", "l": "Formation of collagen fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50416", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176175", "l": "Stalling of DNA replication fork and RPA binding (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75873", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58392", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58915", "l": "ATP + H2O + iron(III) dicitrate(out) <=> ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220966", "l": "NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30233", "l": "(2E,6E)-farnesal + H2O2 + L-cysteine => H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29143", "l": "a ubiquinol + 2 H(+)(in) + nitrate = a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12240", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.165", "l": "\"6-methylsalicylic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33812", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine => 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050364", "l": "tryptophan dimethylallyltransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44979", "l": "(R)-carnitine + propanoyl-CoA <=> CoA + O-propanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52458", "l": "H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP => testosterone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67986", "l": "N-acetyl-D-leucine => N-acetyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40621", "l": "2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+) => H2O + tridodecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30907", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) = 2-methylbutanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31510", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630921", "l": "NFKBIA variant binds NFkB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68610", "l": "Formation of ORC(2-5) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75336", "l": "bromide(in) + chloride(out) => bromide(out) + chloride(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42930", "l": "H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22063", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052934", "l": "alcohol dehydrogenase (cytochrome c) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726580", "l": "PGR binds PGR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30498", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088134", "l": "PLK1 phosphorylates FOXM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168884", "l": "Hemagglutinin (HA) protein synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66096", "l": "3-phenylpyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.38", "l": "\"malate dehydrogenase (oxaloacetate-decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59129", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654159", "l": "Activated FGFR2 binds PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20397", "l": "L-cysteine + O-succinyl-L-homoserine = H(+) + L,L-cystathionine + succinate", "d": [], "t": []}, {"i": "EC:2.5.1.48", "l": "\"cystathionine gamma-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73669", "l": "(E,E)-piperlonguminine + CoA + H(+) => (E,E)-piperoyl-CoA + 2-methylpropan-1-amine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74740", "l": "Binding of SHC1 to insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102598", "l": "3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity", "d": ["Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 = oryzalexin D + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474210", "l": "Collagen type III degradation by MMP14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44549", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196417", "l": "Reduction of desmosterol to cholesterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.1", "l": "\"leucyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38629", "l": "1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.218", "l": "\"morphine 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033509", "l": "USP9X binds Ub:PEX5L (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38367", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA = 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.260", "l": "\"tetracycline polyketide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003785", "l": "actin monomer binding", "d": ["Binding to monomeric actin, also known as G-actin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21544", "l": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.18", "l": "\"farnesyl-diphosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47380", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29306", "l": "2 H(+)(in) + succinate(in) <=> 2 H(+)(out) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33393", "l": "C20 sphinganine + phosphate => C20 sphinganine 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30384", "l": "(2E,6E)-farnesyl diphosphate => (-)-7-epi-alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68768", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031820", "l": "P2Y11 nucleotide receptor binding", "d": ["Binding to a P2Y11 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10803", "l": "diphosphate + XMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712204", "l": "ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863472", "l": "DAB2 binds LRP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377640", "l": "Autophosphorylation of SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36860", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451447", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051787", "l": "misfolded protein binding", "d": ["Binding to a misfolded protein."], "t": []}, {"i": "REACT:R-HSA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851011", "l": "TRIM27 polyubiquitinates PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392143", "l": "NO binds to Guanylate Cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69173", "l": "Joining of adjacent Okazaki fragments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047878", "l": "erythritol kinase activity", "d": ["Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082356", "l": "HSF1-mediated gene expression (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050267", "l": "rubber cis-polyprenylcistransferase activity", "d": ["Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24122", "l": "20-hydroxy-leukotriene E4 + H2O + NADP(+) => H(+) + leukotriene E4 + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32902", "l": "1,8-cineole + O2 + reduced [flavodoxin] <=> 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56041", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097434", "l": "succinate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044508", "l": "glucagon-like peptide 1 receptor activity", "d": ["Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48870", "l": "AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609310", "l": "β-blockers bind ADRB1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211193", "l": "Homodimerization  of DFF40 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65813", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 => A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19867", "l": "4 CO2 + coproporphyrinogen III => 4 H(+) + uroporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30838", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714580", "l": "SLC6A3 binds DRIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803719", "l": "TP53 binds ZNF385A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209566", "l": "TRAF6 is auto-ubiquitinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56102", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate => [small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43435", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] <=> butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15135", "l": "2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36693", "l": "CoA + H(+) + N-octadecanoylsphing-4-enine => octadecanoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1031713", "l": "GAF binds the GAS promoter elements in the IFNG-regulated genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75114", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013006", "l": "RHOA:GTP translocates to the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43825", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35045", "l": "N-(4-aminobenzoyl)-L-glutamate(out) => N-(4-aminobenzoyl)-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13830", "l": "GDP-alpha-D-rhamnose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139919", "l": "Translocation of BIM to mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20120", "l": "ATP + L-rhamnulose <=> ADP + H(+) + L-rhamnulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48706", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0072518", "l": "Rho-dependent protein serine/threonine kinase activity", "d": ["Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830875", "l": "G is palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18115", "l": "a ribonucleoside 5'-triphosphate + ADP => a ribonucleoside 5'-diphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866269", "l": "ARRB bind GPCRs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21153", "l": "trans-4-hydroxy-L-proline => cis-4-hydroxy-D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37195", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18916", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50175", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102650", "l": "cyclo-acetoacetyl-L-tryptophan synthetase activity", "d": ["Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP = cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614460", "l": "Dimerization of procollagen type VI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033520", "l": "TYSND1 cleaves TYSND1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987039", "l": "JAK1 binds IL20RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254291", "l": "ERBB4s80 binds STAT5A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47965", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30507", "l": "2-demethylmenaquinone-8 + H(+) + NADH = 2-demethylmenaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877187", "l": "P2X7 mediates loss of intracellular K+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178218", "l": "SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36908", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39416", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60835", "l": "a 5'-end triphospho-guanosine in mRNA + H2O <=> a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29583", "l": "guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64457", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27754", "l": "H2O + methylglyoxal = (R)-lactate + H(+)", "d": [], "t": []}, {"i": "EC:4.2.1.130", "l": "\"D-lactate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57513", "l": "chlorobenzene + H(+) + NADH + O2 => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708866", "l": "pro-F2R binds vorapaxar (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68945", "l": "esculetin + S-adenosyl-L-methionine => H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69445", "l": "(2E,6E)-farnesyl diphosphate => alpha-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67616", "l": "8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674531", "l": "AAMP binds EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16420", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) <=> H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848606", "l": "PTK6 phosphorylates PXN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003864", "l": "3-methyl-2-oxobutanoate hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47481", "l": "deoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68105", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76600", "l": "(9Z,12Z)-octadecadienoate + H2O => (12Z)-10-hydroxyoctadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928615", "l": "EFNBs bind SFKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29570", "l": "2 chloride(in) + H(+)(out) <=> 2 chloride(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24913", "l": "L,L-cystathionine <=> 2-aminobut-2-enoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61862", "l": "epoxybetaenone + H2O + NADP(+) => dehydroprobetaenone I + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57767", "l": "2,6-dinitrotoluene + NADH + O2 <=> 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46776", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.45", "l": "\"sn-1 oleoyl-lipid 12-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27820", "l": "2-dehydro-L-idonate + H(+) + NADH => L-idonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807106", "l": "PTEN undergoes monoubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54462", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113442", "l": "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623999", "l": "BCL gene expression downstream of ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46539", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42339", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731031", "l": "SARS-CoV-1 6 binds to NPIPB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32381", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH => (1R,2R,4S)-limonene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046910", "l": "pectinesterase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of pectinesterase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098619", "l": "selenocysteine-tRNA ligase activity", "d": ["Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate."], "t": []}, {"i": "REACT:R-HSA-2408526", "l": "tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23955", "l": "H2O + N-(2-phenylethyl)acetamide <=> 2-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59914", "l": "(E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH => (E)-4-hydroxynon-2-enal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432371", "l": "CRY is activated by light and binds to phosphorylated nuclear TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60380", "l": "L-dehydroascorbate(out) = L-dehydroascorbate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62699", "l": "O2 + 4 tellimagrandin II <=> 2 cornusiin E + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23188", "l": "NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.202", "l": "\"1,3-propanediol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48469", "l": "a ganglioside GM1b (d18:1(4E)) + H2O => a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32119", "l": "GDP-valienol + validamine 7-phosphate = GDP + H(+) + validoxylamine A 7'-phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.135", "l": "\"validamine 7-phosphate valienyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015526", "l": "hexose-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44310", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737046", "l": "L-Glutamate binds GRM4 (mGluR4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11773", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13129", "l": "cis-4-coumarate + UDP-alpha-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.209", "l": "\"cis-p-coumarate glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050600", "l": "acyl-CoA 11-(E)-desaturase activity", "d": ["Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11E)-delta11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704297", "l": "CHRM2 binds CHRM2 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24481", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46069", "l": "(3E)-nonenoyl-CoA => (2E)-nonenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54138", "l": "5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA precursor + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39954", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32405", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2S,4R)-neodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156699", "l": "Inactivation of Wee1 kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938815", "l": "RNF152 polyubiquitinates RRAGA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32179", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) = dipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0071553", "l": "G protein-coupled pyrimidinergic nucleotide receptor activity", "d": ["Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69087", "l": "acrolein + H2O + NAD(+) <=> acrylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202203", "l": "Recruitment of PI3K to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60473", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112042", "l": "Opioid binds MOR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10732", "l": "ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": [], "t": []}, {"i": "EC:1.13.12.7", "l": "\"firefly luciferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654514", "l": "KAL1 binds FGFR1c (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77198", "l": "(3Z)-decenoyl-CoA <=> (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48325", "l": "a ganglioside GD1b + GDP-beta-L-fucose => a ganglioside Fuc-GD1b + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62395", "l": "levoglucosan + NAD(+) <=> 3-dehydrolevoglucosan + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45551", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389862", "l": "Conversion of glyoxylate to oxalate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030789", "l": "precorrin-3B C17-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450259", "l": "Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32297", "l": "2 diphosphate + NADP(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395992", "l": "p-T,4S-IRF3 is dimerized (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10140", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2", "d": [], "t": []}, {"i": "EC:1.1.1.188", "l": "\"prostaglandin-F synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69068", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline = A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371554", "l": "HSF1 acetylation at Lys80 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140696", "l": "factor V -> factor Va + factor V activation peptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0102175", "l": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168400", "l": "iE-DAP elicits a NOD1 response (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188985", "l": "trehalose + H2O => 2 D-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27772", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17527", "l": "NH4(+) + urea-1-carboxylate => biuret + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74929", "l": "(2E)-butenoyl-[ACP] + glycine + H2O => (3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008671", "l": "2-dehydro-3-deoxygalactonokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30708", "l": "putrescine + pyruvate => 4-aminobutanal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43556", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.3", "l": "\"omega-amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11924", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.228", "l": "\"lactosylceramide 4-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77684", "l": "a globoside Gb3Cer (d18:1(4E)) + UDP-alpha-D-galactose => a globoside GalGb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32303", "l": "(2R)-homocitrate = (2R,3S)-homoisocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31606", "l": "(Z)-3-ureidoacrylate + H2O <=> (Z)-3-aminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874080", "l": "SRC phosphorylates PTK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76180", "l": "a dipeptide(out) + 2 H(+)(out) => a dipeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50132", "l": "ethyl hexadecanoate + H2O = ethanol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11886", "l": "adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cortisol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626549", "l": "IQGAPs bind CALM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66186", "l": "3',5'-cyclic AMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic AMP(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956676", "l": "YAP1 binds TP73 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70531", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33399", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) = L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.192", "l": "\"protein-N(pi)-phosphohistidine--N-acetylmuramate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-593685", "l": "Netrin-4 binds DCC/UNC5A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678998", "l": "Endosomal TLRs pass through the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21399", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) <=> CO2 + Na(+)(out) + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013004", "l": "RHOA binds effectors at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28130", "l": "baicalin + H2O = baicalein + D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41996", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22453", "l": "[phosphate](n+1) + n H2O => n H(+) + (n+1) phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66240", "l": "ATP + CoA + IC-asc-C9 = AMP + diphosphate + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26023", "l": "8'-apo-beta-carotenol + O2 = (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": [], "t": []}, {"i": "EC:1.13.11.67", "l": "\"8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56867", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47699", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800001", "l": "TP53 family members stimulate FAS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849646", "l": "SPINK5(490-624) binds KLK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160935", "l": "SMURF1 ubiquitinates RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200646", "l": "Cytosolic folate export across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210271", "l": "Interaction of DAP12 and MDL-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43669", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate => 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47993", "l": "H(+)(in) + NAD(+) + NADPH => H(+)(out) + NADH + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70565", "l": "2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.1.3", "l": "\"phosphohistidine phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247510", "l": "MARCO:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668395", "l": "CHMP7 binds CC2D1B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34632", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21138", "l": "CoA + O-acetyl-(R)-carnitine => (R)-carnitine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11348", "l": "arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.3.2.7", "l": "\"arsenite-transporting ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670620", "l": "Defective DAXX does not bind ATRX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15089", "l": "(R)-lactate + A = AH2 + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.99.6", "l": "\"D-lactate dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33160", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70510", "l": "LDH tetramer oxidises LACT to PYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15103", "l": "CO2 + L-lysine => H(+) + meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16793", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.36", "l": "\"phosphopantothenoylcysteine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830917", "l": "EYA1, PAX2, and HOX11 paralog bind the SIX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75341", "l": "chloride(in) + nitrate(out) => chloride(out) + nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46107", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39275", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH = (15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56780", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65384", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34833", "l": "N-acyl-15-methylhexadecasphing-4-enine + phosphate => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47369", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983259", "l": "Kinesins move along microtubules consuming ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62107", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53269", "l": "L-ribulose => L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.13", "l": "\"ABC-type D-xylose/L-arabinose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334794", "l": "FABPs bind LCFAs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362427", "l": "Hh-Np binds GPC5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865107", "l": "MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450975", "l": "isocitrate <=> citrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46168", "l": "ATP + CoA + pentanoate = AMP + diphosphate + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008255", "l": "ecdysis-triggering hormone activity", "d": ["The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044588", "l": "laminaribiose binding", "d": ["Binding to laminaribiose, a disaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003746", "l": "translation elongation factor activity", "d": ["Functions in chain elongation during polypeptide synthesis at the ribosome."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77504", "l": "3-phenylpropanal + hydrogen cyanide => (2S)-2-hydroxy-4-phenylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24034", "l": "6-O-alpha-D-glucopyranosyl-D-fructose => sucrose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38336", "l": "(20S)-ginsenoside Rb1 + 2 H2O => (20S)-ginsenoside Rg3 + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418200", "l": "SRC-1 bound to ARRB2 is not activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28733", "l": "H(+)(in) + L-leucine(out) => H(+)(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140817", "l": "NAD+-histone H3S10 serine ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67906", "l": "3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA => glutaryl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77589", "l": "Recognition of AAUAAA sequence by CPSF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15944", "l": "H2O + N(2)-acetyl-L-ornithine <=> acetate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112437", "l": "Formation of NELF complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26232", "l": "3 NADP(+) + phytyl diphosphate <=> geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112430", "l": "Formation of P-TEFb complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27425", "l": "(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.47", "l": "\"beta-farnesene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46989", "l": "(R)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16830", "l": "an aldehyde + H2O + O2 => a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005035", "l": "death receptor activity", "d": ["Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389970", "l": "Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981610", "l": "Neuroglobin binds oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21564", "l": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.16", "l": "\"acetyl-CoA C-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20350", "l": "H(+) + NADH + O2 + toluene => 2-hydroxytoluene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434130", "l": "IRAK4 binds to activated TLR5 or 15. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373705", "l": "Caspase cleavage of DCC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58626", "l": "dodecanamide + glyoxylate => N-dodecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15268", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65623", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10662", "l": "D-seryl-[protein] => L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033769", "l": "glyceollin synthase activity", "d": ["Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin II or glyceollin III + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin I + NADP+ + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47349", "l": "a butanoate ester + H2O => an aliphatic alcohol + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22397", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => glycolaldehyde + guaiacol + H2O + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37426", "l": "aclacinomycin N + O2 <=> aclacinomycin A + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12634", "l": "benzoate + H(+) + NADH + O2 => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561072", "l": "OCT3 mediates renal uptake of organic cations (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391872", "l": "NCAM1 cis-homophilic interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933533", "l": "Dimerization of p-IRF7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.5", "l": "\"phosphoglucomutase (glucose-cofactor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874079", "l": "AIM2 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602454", "l": "proMMP9 binds TIMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45220", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] = Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43884", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) = 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362465", "l": "GHBP binds GHR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.4", "l": "\"DNA 3'-5' helicase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65831", "l": "H2O + neryl diphosphate <=> diphosphate + nerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50919", "l": "a carboxylate + ATP + H(+) + NADPH <=> AMP + an aldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31021", "l": "4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O => 4 AH2 + all-trans-4,4'-diapolycopene + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37290", "l": "ATP + H2O + L-alanyl-L-leucine(out) <=> ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9035227", "l": "TXN2 binds CysS248-MPST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954117", "l": "E2F6:TFDP1 binds EPC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48961", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39687", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA = (2E,11Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008684", "l": "TBK1 phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17564", "l": "acetylcholine + H2O <=> acetate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102822", "l": "quercetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070402", "l": "NADPH binding", "d": ["Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64669", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4686998", "l": "Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65392", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH = (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58483", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111930", "l": "Adenylate cyclase produces cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71128", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) => H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54413", "l": "a 3-oxo-5beta-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15455", "l": "H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.8", "l": "\"protein-secreting ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141101", "l": "tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + uridine44 in tRNASer = 2'-O-methyluridine44 in tRNASer + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004313", "l": "[acyl-carrier-protein] S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52125", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63088", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49793", "l": "eicosanoyl-CoA + glycine => CoA + H(+) + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204485", "l": "Basigin binds CyPA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69068", "l": "RFC dissociates after sliding clamp formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19092", "l": "S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202443", "l": "Oligomerization of CARMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983144", "l": "Transport of Antigen peptide in to ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204873", "l": "Interaction of Tie2 and Shp2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54132", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33951", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine = 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.285", "l": "\"UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759158", "l": "SQSTM1 oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63503", "l": "H(+) + NADPH + S-nitrosoglutathione <=> NADP(+) + sulfinamide glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18373", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.154", "l": "\"phosphatidylinositol-4-phosphate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683888", "l": "LMCD1 binds GATA6, sequestering it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32020", "l": "(2E,6E)-farnesyl diphosphate => beta-cubebene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61176", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43440", "l": "hexadecanoate + sphinganine = H2O + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210909", "l": "ANTXR1-bound pagA(197-794) forms oligomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59049", "l": "D-ornithine + H(+) => CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51139", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443817", "l": "Phosphorylation of L1 by EPHB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72497", "l": "glutarate(out) + prostaglandin E2(in) => glutarate(in) + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20618", "l": "L-galactono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004998", "l": "transferrin receptor activity", "d": ["Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190265", "l": "FGFR4 binds to FGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679775", "l": "COMT binds COMT Inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953013", "l": "E2F7 binds E2F8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65066", "l": "diphosphate + pestalodiol => dimethylallyl diphosphate + siccayne", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668395", "l": "CHMP7 binds CC2D1B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48625", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15751", "l": "AH2 + phenylglyoxylate => (S)-mandelate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56315", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O <=> 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047977", "l": "hepoxilin-epoxide hydrolase activity", "d": ["Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22935", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18306", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-4-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29541", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110215", "l": "Cleavage of uracil by UNG glycosylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199131", "l": "PVR binds CD226 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64484", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA = 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64584", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) = 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27982", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.20", "l": "\"7-cyano-7-deazaguanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817258", "l": "DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXB gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30249", "l": "O2 + 2 plastoquinol-9 => 2 H2O + 4 hnu + 2 plastoquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443779", "l": "Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23580", "l": "prostaglandin H2 = prostaglandin I2", "d": [], "t": []}, {"i": "EC:5.3.99.4", "l": "\"prostaglandin-I synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201515", "l": "Active ALK recruits PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49022", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654533", "l": "KRAS4B recycles to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74380", "l": "2 (S)-lactate(in) + prostaglandin H2(out) => 2 (S)-lactate(out) + prostaglandin H2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54963", "l": "ATP + CoA + dinor-OPDA <=> AMP + dinor-OPDA-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008855", "l": "exodeoxyribonuclease VII activity", "d": ["Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9639286", "l": "RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49955", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine 1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64099", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] <=> 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54636", "l": "(13E)-labda-7,13-dien-15-yl diphosphate = diphosphate + labda-7,13(16),14-triene", "d": [], "t": []}, {"i": "EC:4.2.3.192", "l": "\"labda-7,13(16),14-triene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71594", "l": "2-oxoglutarate(out) + malonate(in) <=> 2-oxoglutarate(in) + malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507870", "l": "Aquaporins passively transport water out of cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395517", "l": "NADPH transfers electrons to FDXR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47337", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696274", "l": "RND1 binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610726", "l": "The IFT-A complex recruits TULP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944214", "l": "Association of procollagen type I (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20530", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 => 2-cis-(+)-abscisate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11855", "l": "phosphate + S-methyl-5'-thioadenosine <=> adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446364", "l": "Migfilin interacts with VASP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44267", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050365", "l": "tryptophanamidase activity", "d": ["Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8979071", "l": "KDM6B binds iron (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.102", "l": "\"2-alkenal reductase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17508", "l": "H2O + N-(long-chain fatty acyl)ethanolamine <=> a long-chain fatty acid + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60244", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}, {"i": "EC:1.14.99.66", "l": "\"[histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0015035", "l": "protein-disulfide reductase activity", "d": ["Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58844", "l": "(6E)-8-hydroxygeranial + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052817", "l": "very long-chain fatty acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H+. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons."], "t": []}, {"i": "RHEA:67072", "l": "a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209183", "l": "Scaffolding protein CKA binds BSK and phosphorylated HEP kinases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41352", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64266", "l": "atrochrysone + CO2 => atrochrysone carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32566", "l": "(2E)-geranyl diphosphate <=> alpha-terpinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19421", "l": "(R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:1990782", "l": "protein tyrosine kinase binding", "d": ["Binding to protein tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015069", "l": "scyllo-inosamine-4-phosphate amidinotransferase activity", "d": ["Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24374", "l": "H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine => H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953339", "l": "DNPH1 hydrolyses dGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912357", "l": "ITCH ubiquitinates DTX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.-", "l": "\"With reduced pteridine as one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633005", "l": "EIF2AK4 (GCN2) binds tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67775", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O <=> a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60196", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870461", "l": "RABGGTA and RABGGTB bind (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75856", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37144", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71582", "l": "CDP(out) + CDP-L-ribitol(in) <=> CDP(in) + CDP-L-ribitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46642", "l": "7alpha-hydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63233", "l": "(2E)-octenoyl-CoA + H(+) + NADH => NAD(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35071", "l": "4-methylphenol(in) = 4-methylphenol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50829", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15000", "l": "deoxylimonoate + H2O <=> deoxylimononate D-ring-lactone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953037", "l": "E2F8 forms homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63686", "l": "(4R,5S)-dethiobiotin + ADP + H(+) + phosphate => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41349", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32025", "l": "avermitilol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64601", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000155", "l": "phosphorelay sensor kinase activity", "d": ["Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19517", "l": "H2O + N,N-dimethylformamide = dimethylamine + formate", "d": [], "t": []}, {"i": "EC:3.5.1.56", "l": "\"N,N-dimethylformamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033994", "l": "glucuronan lyase activity", "d": ["Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709885", "l": "BIL scavenges NO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676229", "l": "WIPIs bind PI3P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48821", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10329", "l": "an L-glycol + NAD(+) => a 2-hydroxycarbonyl + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14685", "l": "A + a primary alcohol = AH2 + an aldehyde", "d": [], "t": []}, {"i": "EC:1.1.99.20", "l": "\"alkan-1-ol dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77350", "l": "L-alanine + oxaloacetate <=> L-aspartate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170846", "l": "TGFBR2 recruits TGFBR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684096", "l": "CDK2 phosphorylates RBBP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41465", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71752", "l": "2-oxoglutarate(out) + glutarate(in) => 2-oxoglutarate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016828", "l": "hydrolase activity, acting on acid sulfur-sulfur bonds", "d": ["Catalysis of the hydrolysis of any acid sulfur-sulfur bond."], "t": []}, {"i": "EC:3.12.-.-", "l": "\"Acting on sulfur-sulfur bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22016", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) = arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": [], "t": []}, {"i": "EC:1.20.4.1", "l": "\"arsenate reductase (glutathione/glutaredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043262", "l": "ADP phosphatase activity", "d": ["Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9639286", "l": "RRAGC,D exchanges GTP for GDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71698", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) <=> 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38300", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67152", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] = L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-901047", "l": "Binding of ERp57 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77211", "l": "3'-phosphoadenylyl sulfate + taurodeoxycholate = 3alpha-sulfotaurodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45746", "l": "7,8-dihydropteroate + H(+) + NADH => (6S)-5,6,7,8-tetrahydropteroate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72752", "l": "H2O + ochratoxin A => L-phenylalanine + ochratoxin alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780995", "l": "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28175", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => colneleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050697", "l": "1,1,2-trichloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20689", "l": "chlorogenate + H2O = (E)-caffeate + H(+) + L-quinate", "d": [], "t": []}, {"i": "EC:3.1.1.42", "l": "\"chlorogenate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694780", "l": "Spike translocates to ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42878", "l": "H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709842", "l": "MAVS binds TOMM70 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084912", "l": "Arresten binds integrin alpha1beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341294", "l": "Superoxide reduces cytochrome c (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0008195", "l": "phosphatidate phosphatase activity", "d": ["Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730847", "l": "Hydrolysis of PIP2 by PLCG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74707", "l": "Binding of IRS to insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74723", "l": "Endosome acidification (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35065", "l": "NH4(+) + pyrazine-2-carboxylate => H2O + pyrazinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13881", "l": "a quinone + an aldehyde + H2O = a carboxylate + a quinol + H(+)", "d": [], "t": []}, {"i": "EC:1.2.5.2", "l": "\"aldehyde dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-383190", "l": "HCO3- transport through ion channel (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36162", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605060", "l": "Expression of SCD regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18173", "l": "(R)-octopamine = (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": [], "t": []}, {"i": "EC:4.2.1.87", "l": "\"octopamine dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43286", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39122", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111264", "l": "Addition of nucleotides between position +11 and +30 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614605", "l": "Persulfide sulfur is dioxygenated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42002", "l": "an isogloboside iGb3Cer (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790038", "l": "Expression of HSP90B1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19433", "l": "ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.12", "l": "\"gluconokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374689", "l": "Neogenin binds Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182263", "l": "Degradation of MHC I Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848436", "l": "PTK6 phosphorylates CDKN1B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835454", "l": "DNAJC3 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684140", "l": "ATM phosphorylates RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29998", "l": "ATP + H2O + putrescine(out) <=> ADP + H(+) + phosphate + putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.51", "l": "\"3(or 17)beta-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25483", "l": "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37194", "l": "2',3'-cyclophospho-AMP + H2O <=> adenosine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51738", "l": "H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004026", "l": "alcohol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19032", "l": "3 H(+) + H2O + urea-1-carboxylate <=> 2 CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51051", "l": "5alpha-androstan-3,17-dione + A <=> AH2 + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471354", "l": "HNP1-3 bind gp120 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67246", "l": "2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH => 3-deoxyglucosone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.32", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41461", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacylglycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19555", "l": "indole + NH4(+) + pyruvate => H2O + L-tryptophan", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.29", "l": "\"glycerate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782655", "l": "HDAC10 deacetylates histone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53881", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate => ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42115", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) <=> H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30298", "l": "GTP + pyruvate <=> GDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21296", "l": "D-galactose + NAD(+) = D-galactono-1,4-lactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.48", "l": "\"D-galactose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944263", "l": "Association of procollagen type II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46607", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate <=> [HPr protein]-L-serine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9734730", "l": "ORC1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14802", "l": "(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34980", "l": "H(+)(in) => H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46120", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730862", "l": "Autophosphorylation of LYN kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672951", "l": "Inactive RAFs bind YWHAB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31772", "l": "an all-trans-retinyl ester + H2O => 11-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70072", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol => (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30936", "l": "H2O + nicotinate beta-D-ribonucleotide => beta-D-ribosylnicotinate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030621", "l": "U4 snRNA binding", "d": ["Binding to a U4 small nuclear RNA (U4 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470009", "l": "Phosphorylation of STATs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607734", "l": "PKC-delta translocates to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63070", "l": "2 CO2 + 3 CoA + triacetate lactone => acetyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72558", "l": "estrone 3-sulfate(out) + propanoate(in) <=> estrone 3-sulfate(in) + propanoate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58886", "l": "A + chloramphenicol + 2 H2O => AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30559", "l": "GTP + H2O = guanosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69685", "l": "CHEK2 phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873926", "l": "IFNG dimer binds IFNGR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44382", "l": "a ubiquinol + H(+) + S-adenosyl-L-homocysteine => a 3-demethylubiquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70321", "l": "1D-myo-inositol 3,4-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66810", "l": "7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A => 5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.836106170294514", "identifiers": [{"i": "GO:0004364", "l": "glutathione transferase activity", "d": ["Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392206", "l": "G alpha (i) inhibits adenylate cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61801", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine => AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691621", "l": "C5 binds C5 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507873", "l": "Aquaporins passively transport urea out of cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696482", "l": "CTF1 binds LIFR:JAKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948775", "l": "MKRN1 polyubiquitinates PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218814", "l": "PAK2 autophorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11129", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA => 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40612", "l": "H2O + trihexanoylglycerol => 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33846", "l": "H2O + N-tetracosanoylsphinganine <=> sphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162188", "l": "MDMQ10H2 is methylated to DMQ10H2 by COQ5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226999", "l": "ADD1:ADD3 binds DMTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25932", "l": "4-methylquinoline + A + H2O = 4-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51496", "l": "a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202325", "l": "Recruitment of Gads to LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62764", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875568", "l": "RAPGEF1 activates RAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944218", "l": "Association of procollagen type VIII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53360", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) = H(+) + NADPH + uridine(47) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71109", "l": "L-leucine(in) + S-methylmercury-L-cysteine(out) => L-leucine(out) + S-methylmercury-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26471", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate => 16-feruloyloxyhexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11257", "l": "H2O + limonin + UDP-alpha-D-glucose => glucosyl-limonin + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66129", "l": "2-oxobutanoate + L-phenylalanine => (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782138", "l": "ERCC5 and RPA bind TC-NER site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36321", "l": "CoA + 2 NADP(+) + octadecan-1-ol => 2 H(+) + 2 NADPH + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48383", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39016", "l": "22-oxodocosanoate + H2O + NAD(+) => docosanedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20167", "l": "an alcohol + H(+) + N(5)-acyl-L-ornithine => H2O + N(5)-acyl-L-ornithine ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033756", "l": "Oplophorus-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20880", "l": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.66", "l": "\"omega-hydroxydecanoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31847", "l": "(S)-2,3-epoxysqualene = shionone", "d": [], "t": []}, {"i": "EC:5.4.99.46", "l": "\"shionone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58488", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 = H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13500", "l": "5-dehydro-2-deoxy-D-gluconate + ATP <=> 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27557", "l": "all-trans-hexaprenyl diphosphate + 2 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130504", "l": "Cleavage of lip22 to lip10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54637", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => diphosphate + labda-7,13(16),14-triene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0019209", "l": "kinase activator activity", "d": ["Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351208", "l": "Spermidine  => N-acetylated spermidine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21258", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate => 3-phosphoshikimate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700120", "l": "PTN and MDK bind to PTPRZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983259", "l": "Kinesins move along microtubules consuming ATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16035", "l": "CO2 + gibberellin A19 + H2O + succinate => 2-oxoglutarate + gibberellin A44 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70481", "l": "TPI1 isomerizes GA3P to DHAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71211", "l": "chlorate(out) + 2 Na(+)(out) = chlorate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5603467", "l": "Activated protein C is released from PROCR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18937", "l": "an N-acyl-L-homoserine lactone + H2O = a carboxylate + L-homoserine lactone", "d": [], "t": []}, {"i": "EC:3.5.1.97", "l": "\"acyl-homoserine-lactone acylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659611", "l": "ANO1 inhibitors bind ANO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50445", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 => prostaglandin G3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41295", "l": "H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17215", "l": "UDP-N-acetyl-alpha-D-mannosamine => UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32703", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = 8-hydroxycopalyl diphosphate", "d": [], "t": []}, {"i": "EC:4.2.1.133", "l": "\"copal-8-ol diphosphate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66988", "l": "4-methylpentanoate + ATP + CoA = 4-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10524", "l": "2-oxoglutarate + H(+) = CO2 + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:4.1.1.71", "l": "\"2-oxoglutarate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.5", "l": "\"aldehyde oxygenase (deformylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32085", "l": "CMP-pseudaminate + diphosphate => CTP + pseudaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483186", "l": "PC is converted to PS by PTDSS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26043", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-9-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112395", "l": "Abortive termination of elongation after arrest (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010357", "l": "homogentisate solanesyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9717841", "l": "holo-FDPS dimer binds NBPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004500", "l": "dopamine beta-monooxygenase activity", "d": ["Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112604", "l": "Phosphorylated STATs are released (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653936", "l": "Formation of Ragulator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58949", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43772", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.264", "l": "\"23S rRNA (guanine(2069)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011975", "l": "Estrogen-responsive MYC gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26451", "l": "CoA + NADP(+) + succinate semialdehyde => H(+) + NADPH + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74986", "l": "Elongation of pre-rRNA transcript (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877884", "l": "RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008951", "l": "palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity", "d": ["Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877361", "l": "Pyrin binds ASC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2429719", "l": "MCPH1 sequesters condensin II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61999", "l": "L-lysyl-[protein] + lactoyl-CoA <=> CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17118", "l": "ATP + L-glutamate + methylamine => ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043014", "l": "alpha-tubulin binding", "d": ["Binding to the microtubule constituent protein alpha-tubulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047343", "l": "glucose-1-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467209", "l": "Binding of defensins to lipid II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54959", "l": "ATP + CoA + OPC-6 <=> AMP + diphosphate + OPC-6-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203979", "l": "Coat Assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69518", "l": "H2O2 + N-acetyl-D-galactosamino-1,5-lactone => N-acetyl-D-galactosamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49130", "l": "5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine => AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39574", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19890", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617829", "l": "Assembly of IFT A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938356", "l": "RMB14 binds RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59609", "l": "beta-alanyl-L-lysine + H2O => beta-alanine + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046180", "l": "KSPG is secreted from the cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418662", "l": "Src activation following P2Y purinoceptor activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16572", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 <=> (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112042", "l": "Opioid binds MOR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430096", "l": "GP1b-IX-V binds filamin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53027", "l": "a plastoquinone + H2O + L-arginine <=> 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49384", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76751", "l": "5-hydroxydodecanoate + H(+) = delta-dodecalactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50018", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine => H2O + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50022", "l": "adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+) => decanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247497", "l": "ERBB3 binds neuregulins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211239", "l": "SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614271", "l": "Autocleavage of ADGRG6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72476", "l": "cis-aconitate(in) + citrate(out) => cis-aconitate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848930", "l": "PTK6 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57553", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218821", "l": "PDK1 phosphorylates PKC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25159", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0035064", "l": "methylated histone binding", "d": ["Binding to a histone in which a residue has been modified by methylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54245", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750226", "l": "NLRC5 binds IKBKB and CHUK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.249098858391747", "identifiers": [{"i": "GO:0019213", "l": "deacetylase activity", "d": ["Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule."], "t": []}, {"i": "REACT:R-HSA-5689000", "l": "AADAC deacetylates PHEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19756", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16489", "l": "(R)-prunasin + H2O = D-glucose + mandelonitrile", "d": [], "t": []}, {"i": "EC:3.2.1.118", "l": "\"prunasin beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23815", "l": "(+)-neomenthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56216", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813740", "l": "GDE1 hydrolyzes GroPIns (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50626", "l": "a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+) => acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64748", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211960", "l": "CYP2U1 19-hydroxylates ARA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63216", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine = 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201639", "l": "Caspase-mediated cleavage of GAS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50679", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] <=> N-terminal L-aspartyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247841", "l": "PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112755", "l": "SOCS3 binds IL6ST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028263", "l": "PGJ3 isomerises to δ12-PGJ3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187506", "l": "Translocation of p27 to the nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-874087", "l": "SGT1 binds HSP90 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211948", "l": "CYP3A4 can N-demethylate loperamide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203553", "l": "eNOS binds NOSIP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202489", "l": "Oligomerization of Bcl10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33369", "l": "D-glucose 6-phosphate(in) + L-histidyl-[protein] => D-glucose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033816", "l": "diaminobutyrate acetyltransferase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60475", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651697", "l": "Defective SLC34A2 does not cotransport Pi, 3Na+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33223", "l": "2-oxobutanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64156", "l": "an N-(fatty acyl)-L-methionine + H2O = a fatty acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106417", "l": "dopaminechrome tautomerase activity", "d": ["Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole."], "t": []}, {"i": "RHEA:70199", "l": "dopaminechrome = 5,6-dihydroxyindole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55103", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37390", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55904", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.60", "l": "\"7-chloro-L-tryptophan 6-halogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48731", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38195", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733960", "l": "Bile salts and acids dissociate from ALB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682967", "l": "WHSC1 binds DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042912", "l": "colicin transmembrane transporter activity", "d": ["Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080133", "l": "midchain alkane hydroxylase activity", "d": ["Catalysis of the conversion of an alkane to a secondary alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848713", "l": "PTK6 binds BCAR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014454", "l": "RHOG translocates to the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27802", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.91", "l": "\"all-trans-decaprenyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46663", "l": "H(+) + NADPH + progesterone <=> 5beta-pregnan-3,20-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864577", "l": "TFAP2C translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50232", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.20", "l": "\"heme oxygenase (biliverdin-producing, ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018710", "l": "acetone carboxylase activity", "d": ["Catalysis of the reaction: acetone + ATP + CO2 + 2 H2O = acetoacetate + AMP + 4 H+ + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74669", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(+) + H2O => (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47877", "l": "a ganglioside GD1b + H2O => a ganglioside GM1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66688", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 = (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42187", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018505", "l": "cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839634", "l": "CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37564", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59690", "l": "D-maltoheptaono-1,5-lactone + H2O2 => D-maltoheptaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66702", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612219", "l": "ERBB4s80 binds to SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252072", "l": "AZGP1 binds PIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26283", "l": "acetaldehyde + Co-precorrin-5B + H(+) => Co-precorrin-5A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67206", "l": "acetate + tryptamine => H2O + N-acetyltryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18102", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) => 3-ethylcatechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14014", "l": "3'-phosphoadenylyl sulfate + taurolithocholate => adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.202", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24624", "l": "ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": [], "t": []}, {"i": "EC:6.1.1.3", "l": "\"threonine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.266", "l": "\"glucosyl-3-phosphoglycerate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77077", "l": "Capping complex formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22575", "l": "A + H2O + N-methyl-L-glutamate <=> AH2 + formaldehyde + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34819", "l": "dihydrocurcumin + NADP(+) = curcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56375", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61930", "l": "(R)-miconazole(out) + ADP + H(+) + phosphate => (R)-miconazole(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017398", "l": "NOTCH3 coactivator complex binds HEYL gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17644", "l": "H(+) + L-arginine <=> agmatine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18524", "l": "licodione + S-adenosyl-L-methionine <=> 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036487", "l": "nitric-oxide synthase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of nitric oxide synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698008", "l": "FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67087", "l": "ATP + H2O + hexacosanoate(in) <=> ADP + H(+) + hexacosanoate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66559", "l": "dopamine + L-glutaminyl-[protein] <=> 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016691", "l": "chloride peroxidase activity", "d": ["Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39861", "l": "a triacyl-sn-glycerol + glycerol => a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706323", "l": "Active FLT3 binds to SLA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26251", "l": "2 H2O + levopimaradienal + NADP(+) => H(+) + levopimaradienol + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005169", "l": "neurotrophin TRKB receptor binding", "d": ["Binding to a neurotrophin TRKB receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102659", "l": "UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate = H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936380", "l": "Interaction of PIN1 with p-IRF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031299", "l": "taurine-pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48317", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate => a ganglioside GD1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47208", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25828", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 = A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29637", "l": "alpha-D-glucose + D-maltotetraose => D-maltopentaose + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0042132", "l": "fructose 1,6-bisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43838", "l": "26-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0016894", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters."], "t": []}, {"i": "EC:3.1.31.1", "l": "\"micrococcal nuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62457", "l": "ATP + H(+) + L-glutamate => diphosphate + L-glutamyl-5'-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685319", "l": "CX3 complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1370500", "l": "PRLR binds SCF beta-TrCP complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42706", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => hercynine + L-cysteine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112703", "l": "PTPN11 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848392", "l": "IL18BP binds IL18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030977", "l": "taurine binding", "d": ["Binding to taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53763", "l": "allocholate + deoxycholoyl-CoA <=> allocholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76103", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine = (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.84", "l": "\"glucan 1,3-alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57672", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] = 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663105", "l": "p-BMAL1:p-CLOCK,NPAS2 binds BHLHE41 (DEC2) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70543", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.22", "l": "\"aminopeptidase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14929", "l": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102475", "l": "2-hydroxyeriodictyol 6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol = isoorientin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813626", "l": "LEAP2 binds bacteria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33238", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 <=> 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51477", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30133", "l": "H(+) + holo-[ACP] + octanoate => H2O + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164617", "l": "Elongation of Extended Telomeric Chromosome End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72926", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693243", "l": "RHOD translocates to the Golgi membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46454", "l": "cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu) => 2 L-leucyl-tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016162", "l": "cellulose 1,4-beta-cellobiosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71375", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) = 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000210", "l": "NAD+ diphosphatase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = AMP + NMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17176", "l": "glutathionylspermidine + H2O <=> glutathione + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40132", "l": "(9Z)-hexadecenoyl-CoA + H2O => (9Z)-hexadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047310", "l": "glutamine-scyllo-inositol transaminase activity", "d": ["Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874080", "l": "SRC phosphorylates PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17619", "l": "glutathione + leukotriene A4 => leukotriene C4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.200", "l": "\"tetracenomycin A2 monooxygenase-diooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30693", "l": "formaldehyde + 2 H2O => H2O2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67228", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA = (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32864", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64631", "l": "acetyl-CoA + octan-1-ol <=> CoA + octyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20847", "l": "ATP + hydrogencarbonate + pyruvate <=> ADP + H(+) + oxaloacetate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63066", "l": "3 CO2 + 4 CoA + tetraacetate lactone => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.182", "l": "\"4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27593", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17556", "l": "ATP + guanidinoethyl methyl phosphate <=> ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20217", "l": "H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde", "d": [], "t": []}, {"i": "EC:4.1.2.32", "l": "\"trimethylamine-oxide aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016085", "l": "myoinhibitory hormone activity", "d": ["The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42321", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052639", "l": "salicylic acid glucosyltransferase (ester-forming) activity", "d": ["Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73692", "l": "3'-AMP(out) + phosphate(in) => 3'-AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51747", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704692", "l": "SARS-CoV-1 7a binds BCL2L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419351", "l": "PAF receptor binds platelet activating factor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149519", "l": "MMACHC decyanates CNCbl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189069", "l": "sucrose + H2O => glucose + fructose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17720", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.7", "l": "\"ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase ferredoxin-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10833", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O => 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005302", "l": "L-tyrosine transmembrane transporter activity", "d": ["Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38679", "l": "ATP + H2O + sphinganine(in) = ADP + H(+) + phosphate + sphinganine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41049", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163810", "l": "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10857", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10840", "l": "H2O + O-phospho-L-homoserine = L-threonine + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.1", "l": "\"threonine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0043211", "l": "ABC-type carbohydrate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32178", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389348", "l": "Activation of Rac1 by pVav1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24994", "l": "2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102799", "l": "glucosinolate glucohydrolase activity", "d": ["Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051996", "l": "squalene synthase activity", "d": ["Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22995", "l": "3-oxopropanoate + CoA + NAD(+) <=> acetyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34236", "l": "4-nitro-6-oxohepta-2,4-dienedioate => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74571", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] = N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45158", "l": "3-oxopropanoate + CoA + H(+) => 3-oxopropanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39053", "l": "ADP + cholesterol(out) + H(+) + phosphate => ATP + cholesterol(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913725", "l": "viral dsRNA binds IFIH1:TKFC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177937", "l": "Phosphorylation of EGFR by SRC kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43897", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24405", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => acetoacetate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19399", "l": "CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + CTP + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55236", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16828", "l": "ATP + uridine <=> ADP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70330", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867344", "l": "OMA1 hydrolyses OPA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54137", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13091", "l": "6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite => 6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193981", "l": "CYP21A2 oxidises 17HPROG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9620103", "l": "ALDH2 transforms GTN to NO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64137", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine => (9Z)-octadecenoate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692408", "l": "NPR2 binds NPPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41032", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603719", "l": "Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56403", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12074", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.85", "l": "\"limulus clotting factor B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52050", "l": "(9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754974", "l": "ADK phosphorylates RBV (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10374", "l": "benzoyl-CoA + CO2 + NADH => CoA + NAD(+) + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38432", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58938", "l": "all-trans-lycopaoctaene + 2 diphosphate + NAD(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39128", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102977", "l": "nitrilotriacetate monooxygenase activity (FMN-dependent)", "d": ["Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51445", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44624", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.384", "l": "\"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71518", "l": "hypoxanthine(out) <=> hypoxanthine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36414", "l": "7-dehydrocholesterol + hnu <=> calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52239", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68931", "l": "ATP + H(+) + heptanoate + NADPH <=> AMP + diphosphate + heptanal + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.53", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60391", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41611", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose <=> 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.126200859969501", "identifiers": [{"i": "GO:0035250", "l": "UDP-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050198", "l": "pinosylvin synthase activity", "d": ["Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H+ + 3 malonyl-CoA = 4 CO2 + 4 CoA + pinosylvin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047184", "l": "1-acylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18948", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782859", "l": "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29997", "l": "ADP + H(+) + phosphate + putrescine(in) => ATP + H2O + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28277", "l": "(S)-S-adenosyl-L-methionine <=> (R)-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47730", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64701", "l": "1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72621", "l": "Ribosomal scanning  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070906", "l": "aspartate:alanine antiporter activity", "d": ["Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)."], "t": []}, {"i": "RHEA:33139", "l": "L-alanine(out) + L-aspartate(in) = L-alanine(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44712", "l": "a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10435", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O <=> acetate + CO2 + NH4(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353313", "l": "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70650", "l": "D-serine(out) + H(+)(out) <=> D-serine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372697", "l": "Crk binding to p130cas (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53470", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14651", "l": "demethylmacrocin + dTDP + H(+) => demethyllactenocin + dTDP-beta-L-mycarose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709098", "l": "DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73906", "l": "ATP + ethanolamine + L-glutamate <=> ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77312", "l": "glyoxylate + N(omega),N(omega)-dimethyl-L-arginine => 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20999", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (3E)-2-oxohex-3-enedioate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69406", "l": "uracil(out) => uracil(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33665", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654399", "l": "Activated FGFR2 binds FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43734", "l": "a 1,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.59", "l": "\"juvenile-hormone esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17680", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.47", "l": "\"N-acylsphingosine galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39752", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659611", "l": "ANO1 inhibitors bind ANO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69058", "l": "H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+) => H(+) + N(omega)-methyl-L-arginine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72336", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate => 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102927", "l": "beta-chaconine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.69", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12972", "l": "a sn-glycero-3-phosphodiester + H2O <=> an alcohol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33907", "l": "4-(methylamino)butanoate + H2O + O2 = 4-aminobutanoate + formaldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.19", "l": "\"4-methylaminobutanoate oxidase (formaldehyde-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70361", "l": "CoA + H(+) + N-acyl-3-oxosphinganine => 3-oxosphinganine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17066", "l": "(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75838", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38570", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072373", "l": "alpha-carotene epsilon hydroxylase activity", "d": ["Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22466", "l": "2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694793", "l": "Spike protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607753", "l": "CARD9 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653936", "l": "Formation of Ragulator complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004409", "l": "homoaconitate hydratase activity", "d": ["Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75567", "l": "acetyl-CoA + cyathatriol = 11-O-acetylcyathatriol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65005", "l": "ATP + decanoate + holo-[ACP] => AMP + decanoyl-[ACP] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62770", "l": "4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61633", "l": "5-aminopentanal + H2O + NAD(+) => 5-aminopentanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047290", "l": "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "d": ["Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837034", "l": "SLIRP:LRPPRC binds mitochondrial RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621918", "l": "Defective GCK does not phosphorylate Glc to form G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247922", "l": "GGCT transforms gGluCys to OPRO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41073", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210426", "l": "Glutamate synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102068", "l": "alpha-humulene 10-hydroxylase activity", "d": ["Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ = 10-hydroxy-alpha-humulene + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14754", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047926", "l": "geranyl-diphosphate cyclase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45469", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate => (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54608", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168272", "l": "Binding of the influenza virion to the host cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357483", "l": "RAC1 binds PAK1-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17164", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> 2-oxopent-4-enoate + benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033478", "l": "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69763", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) = a medium chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26153", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil => 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68777", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70908", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26485", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate <=> diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38912", "l": "avenacoside B + H2O => 26-desgluco-avenacoside B + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8873946", "l": "OTUD3 deubiquitinates PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72207", "l": "chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.137", "l": "\"N-methylcarbamate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60945", "l": "quercetin + S-adenosyl-L-methionine => H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433374", "l": "Processing of SCF isoform 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46500", "l": "2-oxoglutarate + O2 + UMP = CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": [], "t": []}, {"i": "EC:1.14.11.49", "l": "\"uridine-5'-phosphate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050465", "l": "nitroquinoline-N-oxide reductase activity", "d": ["Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31035", "l": "arabidiol = (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.124", "l": "\"arabidiol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419254", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61950", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64416", "l": "D-xylofuranose + NADP(+) = D-xylono-1,4-lactone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.424", "l": "\"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,4-lactone-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43025", "l": "an S-substituted L-cysteine => 2-aminoprop-2-enoate + a thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34424", "l": "(-)-secoisolariciresinol + NADP(+) => (+)-lariciresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13064", "l": "O2 + S-sulfanylglutathione <=> glutathione S,S-dioxide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16446", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone => daidzein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014433", "l": "RHOG GEFs activate RHOG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46564", "l": "acetyl-CoA + apo-[ACP] = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70041", "l": "3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49969", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47976", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388831", "l": "Phosphorylation of CD28 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482770", "l": "Release of platelet secretory granule components (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42419", "l": "a ubiquinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199154", "l": "CD200 binds to CD200R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608855", "l": "PRICKLE1 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45661", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68119", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol <=> a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374909", "l": "Catabolism of Noradrenaline (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48609", "l": "A + a 2,3-saturated acyl-CoA => a 2,3-dehydroacyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001064", "l": "single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399996", "l": "AKT1 E17K mutant phosphorylates CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43197", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine => 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645672", "l": "p14ARF translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76720", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74327", "l": "O-propanoyl-(R)-carnitine(in) = O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22641", "l": "NADP(+) + sphinganine => 3-oxosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69236", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate = 4-hydroxybutylnitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54813", "l": "(+)-7-isojasmonate + ATP + L-isoleucine => AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29431", "l": "ATP + phosphate = ADP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21076", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine", "d": [], "t": []}, {"i": "EC:1.14.11.3", "l": "\"pyrimidine-deoxynucleoside 2'-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71050", "l": "Trimerization of the FASL:FAS receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12938", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618584", "l": "CEBPB and phospho-STAT3 bind the promoter of the MYC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.2", "l": "\"membrane alanyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27653", "l": "GTP + uridine <=> GDP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62440", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) = 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": [], "t": []}, {"i": "EC:4.2.2.27", "l": "\"pectin monosaccharide-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74180", "l": "a secondary alkyl amine + H2O + NADP(+) => a ketone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57000", "l": "acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050618", "l": "phycoerythrobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56989", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.286", "l": "\"chalcone 4'-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450474", "l": "MK2 phosphorylates BRF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62521", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69679", "l": "apigenin 7-O-beta-D-glucoside + H2O = apigenin + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951966", "l": "EP300 acetylates RUNX3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21744", "l": "S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:4.4.1.14", "l": "\"1-aminocyclopropane-1-carboxylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110215", "l": "Cleavage of uracil by UNG glycosylase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448629", "l": "IL33 binds IL1RL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990841", "l": "promoter-specific chromatin binding", "d": ["Binding to a section of chromatin that is associated with gene promoter sequences of DNA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784189", "l": "JAKs bind LIFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668714", "l": "RAC1:GTP binds NOX1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047035", "l": "testosterone dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798082", "l": "TP53 family members bind the CASP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804099", "l": "HMGB1 binds LTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39653", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702849", "l": "CALCR binds gepants (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811412", "l": "Active ARF recruits coatomer to the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428909", "l": "Activated TP receptor binds G-protein  G13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004897", "l": "ciliary neurotrophic factor receptor activity", "d": ["Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44919", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH <=> (3E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49485", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74479", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 = (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17470", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44630", "l": "H(+) + L-anticapsin + NADH => L-dihydroanticapsin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647631", "l": "GSDMD (1-275) binds PIPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47954", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+) => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24608", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.41", "l": "\"5-dehydro-4-deoxyglucarate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013145", "l": "RAC1 binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948757", "l": "AKT phosphorylates MKRN1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692376", "l": "BCL2 binds BCL2 antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42300", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.n5", "l": "\"glycerol-3-phosphate acyltransferase (acyl-[acyl-carrier-protein]-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25219", "l": "CoA + H(+) + N-acetylserotonin => acetyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44947", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63795", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696358", "l": "TREM,CD300 binds lipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419003", "l": "Interaction of Nectins with Afadin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10474", "l": "propanoate + pyruvate => (2R,3S)-2,3-dimethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40446", "l": "6-deoxy-6-sulfo-D-fructose + ATP <=> 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23658", "l": "3-carboxy-cis,cis-muconate + H(+) => 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67088", "l": "ATP + H2O + tetracosanoate(in) = ADP + H(+) + phosphate + tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13967", "l": "L-homocysteine + NH4(+) + pyruvate => H2O + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66933", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate => avenanthramide A + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65387", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20747", "l": "NADP(+) + prostaglandin D2 <=> 15-oxoprostaglandin D2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34448", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43785", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003862", "l": "3-isopropylmalate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159250", "l": "ATF7IP binds SETDB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36263", "l": "hydroxyurea + O-acetyl-L-serine = acetate + H(+) + O-ureido-L-serine", "d": [], "t": []}, {"i": "EC:2.6.99.3", "l": "\"O-ureido-L-serine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54817", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] => [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102824", "l": "UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose = H+ + quercetin 3-O-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22280", "l": "O-demethylpuromycin + S-adenosyl-L-methionine = H(+) + puromycin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.38", "l": "\"O-demethylpuromycin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016004", "l": "phospholipase activator activity", "d": ["Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73305", "l": "H(+)(out) + oxaloacetate(in) + phosphate(out) => H(+)(in) + oxaloacetate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24713", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018794", "l": "RHOV binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39887", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28804", "l": "H2O + L-ascorbate 6-phosphate => 3-dehydro-L-gulonate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033976", "l": "2-haloacid dehalogenase (configuration-inverting) activity", "d": ["Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54917", "l": "9-cis-retinol + NADP(+) => 9-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57752", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64753", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O => 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210309", "l": "Interaction of DAP12 and KIR2DS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22726", "l": "a sterol 3-beta-D-glucoside + H(+) + UDP => a sterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0015159", "l": "polysaccharide transmembrane transporter activity", "d": ["Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74842", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) <=> UDP(out) + UDP-alpha-D-glucuronate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60031", "l": "(2E)-geranyl diphosphate + H2O <=> 4-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64064", "l": "(1R,2R)-pseudoephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21256", "l": "3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.19", "l": "\"3-phosphoshikimate 1-carboxyvinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026891", "l": "NTRK2 activates RAS signaling through SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668404", "l": "TNFA binds TNFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53287", "l": "NAD(+) + scyllo-inosose <=> 3-dehydro-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430311", "l": "Rsu-1 interacts with Pinch1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24630", "l": "5 H(+) + 3 NADH + nitrite => 2 H2O + 3 NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004819", "l": "glutamine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70916", "l": "guanosine(in) + H(+)(in) => guanosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.23", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482770", "l": "Release of platelet secretory granule components (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32312", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66271", "l": "CoA + nonanoyl-AMP <=> AMP + H(+) + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48282", "l": "a ganglioside GM1 + H(+) + UDP => a ganglioside GM2 + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23673", "l": "a quinone + L-quinate => 3-dehydroquinate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17928", "l": "alpha-L-arabinopyanose + NAD(+) <=> H(+) + L-arabinono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57403", "l": "3-O-acetylpapaveroxine + H2O <=> acetate + H(+) + narcotine hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161282", "l": "Elastic fibres bind associated proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32587", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634861", "l": "NPAS4 binds ARNT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44829", "l": "(R)-carnitine + decanoyl-CoA => CoA + O-decanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62785", "l": "2 fonsecin B + H(+) + NADPH + O2 => bifonsecin B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691131", "l": "CANDI binds CUL1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36740", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35986", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022141", "l": "Prolysyl oxidase activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159796", "l": "Furin cleaves pro-factor IX to factor IX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67444", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43997", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 => a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40296", "l": "ATP + CoA + hexadecanedioate => AMP + diphosphate + hexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39172", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0004363", "l": "glutathione synthase activity", "d": ["Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093342", "l": "SDC2 multimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42147", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008254", "l": "3'-nucleotidase activity", "d": ["Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9732629", "l": "PPARG binds PPARG agonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008412", "l": "CDK4 phosphorylates RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067640", "l": "IL6 binds IL6R-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31809", "l": "alpha-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48510", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30102", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35340", "l": "3-hydroxyicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47438", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA => (2E,7Z)-hexadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050508", "l": "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718360", "l": "GNRHR binds GNRHR peptide agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31365", "l": "2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n) => NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37184", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39073", "l": "(2E)-dodecenedioyl-CoA + H2O2 => dodecanedioyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38522", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047746", "l": "chlorophyllase activity", "d": ["Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610722", "l": "CK1 phosphorylates p-GLI3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000832", "l": "inositol hexakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262606", "l": "XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682011", "l": "LC3 binds ATG7 dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620813", "l": "RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62560", "l": "(4R)-limonene + A + H2O = (4R)-perillyl alcohol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102746", "l": "tetrahydrogeranylgeranyl-PP reductase activity", "d": ["Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43313", "l": "ATP + N-(hexanoyl)sphing-4-enine => ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76845", "l": "H(+) + NADH + NH4(+) + octanal => H2O + NAD(+) + octylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42702", "l": "6-carboxyhexanoyl-[ACP] + H(+) + methanol => 6-carboxyhexanoyl-[ACP] methyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451505", "l": "Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54549", "l": "D-xylulose 1,5-bisphosphate + H2O => D-xylulose 5-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.-", "l": "\"Acting on ATP; involved in cellular and subcellular movement\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72822", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23620", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.3.4", "l": "\"(carboxyethyl)arginine beta-lactam-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53169", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674562", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69824", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56580", "l": "6-thioguanine + S-adenosyl-L-methionine = 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050203", "l": "oxalate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H+ + oxalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181155", "l": "The NODAL Receptor binds NODAL ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44277", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44651", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592398", "l": "Activation of proMMP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59814", "l": "CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein] => hexadecanoyl-CoA + N-terminal glycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757256", "l": "MCM3 binds MCM5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618811", "l": "Calcium binds calmodulin at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102793", "l": "soyasapogenol B glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B = H+ + UDP + soyasapogenol B 3-O-beta-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65595", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.13", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28757", "l": "a ubiquinol + dihydroxyacetone phosphate => a ubiquinone + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66745", "l": "ATP + H2O + N-acetyl-L-aspartate(in) => ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47265", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA => AMP + diphosphate + pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66267", "l": "ATP + H(+) + nonanoate <=> diphosphate + nonanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42317", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19806", "l": "a purine D-ribonucleoside + phosphate => a purine nucleobase + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683624", "l": "mRNA2 is translated to Spike (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004365", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47798", "l": "an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => an aralkylamine + H2O + 2 oxidized [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014293", "l": "RAC2 GDIs block activation of RAC2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190245", "l": "FGFR1b binds to FGF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831714", "l": "M forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14973", "l": "L-aspartate = D-aspartate", "d": [], "t": []}, {"i": "EC:5.1.1.13", "l": "\"aspartate racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10160", "l": "L-iditol + NAD(+) = H(+) + keto-L-sorbose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448744", "l": "IL20RA binds IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63182", "l": "H(+) + NADP(+) + 2 superoxide => NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35498", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate <=> 4-aminobenzoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10165", "l": "(2R)-2-phosphoglycerate => H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981606", "l": "Myoglobin binds oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63400", "l": "Fe(II)-hydroxyheme i = Fe(II)-heme a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71553", "l": "5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine => 5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855160", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50260", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956676", "l": "YAP1 binds TP73 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.32", "l": "\"codeine 3-O-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937792", "l": "RUNX3 binds SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77524", "l": "butanal + hydrogen cyanide => (2S)-2-hydroxypentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71429", "l": "3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26462", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65531", "l": "hexan-1-ol + octanoyl-CoA <=> CoA + hexyl octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189488", "l": "UROS transforms HMB to URO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362386", "l": "Glycosylation of Hh (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41811", "l": "(3R)-hydroxybutanoyl-[ACP] <=> (2E)-butenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28635", "l": "(2E,6E)-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.61", "l": "\"5-epiaristolochene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39801", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103105", "l": "2-oxo-6-methylthiohexanoate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid = dihomomethionine + a 2-oxo carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070005", "l": "cysteine-type aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52207", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047882", "l": "estradiol 6-beta-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + estradiol-17beta + O2 = 6beta-hydroxyestradiol-17beta + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58079", "l": "1-(11Z-eicosenoyl)-glycerol + H2O <=> (11Z)-eicosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53202", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944215", "l": "Association of procollagen type XX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371467", "l": "SIRT1 deacetylates HSF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63908", "l": "ATP + H2O + pravastatin(in) = ADP + H(+) + phosphate + pravastatin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15367", "l": "3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41890", "l": "(3R)-hydroxytetradecanoyl-[ACP] + NADP(+) => 3-oxotetradecanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54146", "l": "5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28875", "l": "H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60762", "l": "CoA + jasmolin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42162", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371527", "l": "HSF1 trimer translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35664", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25429", "l": "ATP + N-acetyl-D-hexosamine => ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033737", "l": "1-pyrroline dehydrogenase activity", "d": ["Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21547", "l": "(2E,6E)-farnesyl diphosphate + ATP <=> (2E,6E)-farnesyl triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15298", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14280", "l": "(S)-lactaldehyde + H2O + NAD(+) <=> (S)-lactate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033754", "l": "indoleamine 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110068", "l": "glucosylglycerate phosphorylase activity", "d": ["Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102305", "l": "(13E)-labda-7,13-dien-15-ol synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062181", "l": "1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity", "d": ["Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]."], "t": []}, {"i": "RHEA:49192", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43877", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77344", "l": "N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate => 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37339", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O = (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853444", "l": "AURKA phosphorylates PHLDA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55951", "l": "A + D-alanine + H2O <=> AH2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44159", "l": "1D-myo-inositol 5-phosphate + H2O <=> myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851352", "l": "CCR8 binds CCL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12519", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-(R)-germacrene A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49839", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine <=> (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64859", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + phomopsene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18994", "l": "(9Z,12Z)-octadecadienoate + O2 => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18364", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67515", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43116", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38824", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73864", "l": "dopamine(out) => dopamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030557", "l": "tRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005020", "l": "stem cell factor receptor activity", "d": ["Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33253", "l": "6-kestotriose + beta-D-glucose => 2 sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71624", "l": "malonate(out) + phosphate(in) => malonate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047205", "l": "quinate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37631", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1467466", "l": "ABCA4 mediates atRAL transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52894", "l": "H(+) + NADPH + nitrobenzene => H2O + NADP(+) + nitrosobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44685", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683734", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73927", "l": "griseophenone D + S-adenosyl-L-methionine = griseophenone C + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15334", "l": "(S)-ureidoglycolate + NADP(+) => H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26315", "l": "dihydroxyacetone phosphate + L-aspartate 4-semialdehyde => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52003", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48710", "l": "a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37017", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32666", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine <=> 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088134", "l": "PLK1 phosphorylates FOXM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21837", "l": "D-arabinonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796058", "l": "AcK-NFE2L2 binds the TXN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58223", "l": "L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58456", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose", "d": [], "t": []}, {"i": "EC:3.2.1.170", "l": "\"mannosylglycerate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76745", "l": "7-tetradecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18460", "l": "D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102516", "l": "delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose = delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44616", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28524", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate => D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58891", "l": "4-aminobenzoate + AH2 + 2 O2 <=> 4-nitrobenzoate + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52005", "l": "H2O + methylglyoxal + NAD(+) => 2 H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21157", "l": "(2R)-2-phosphoglycerate + H2O => (R)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50682", "l": "N-terminal L-glutamyl-[protein] + NH4(+) => H2O + N-terminal L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602549", "l": "Defective TLR3 does not bind viral dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420977", "l": "Ca permeable AMPA receptor ligand binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54614", "l": "2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylbutanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690997", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69844", "l": "a 5,6-dihydrouridine in RNA + NAD(+) => a uridine in RNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30378", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-thujopsene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47447", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA <=> (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662837", "l": "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391158", "l": "SIRP alpha binds CD47 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68577", "l": "ATP + H2O + xanthine(out) => ADP + H(+) + phosphate + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70582", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41757", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810392", "l": "TMEM55B translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.39", "l": "\"deuterolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3244643", "l": "STING binds cyclic GMP-AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12965", "l": "ATP + D-galacturonate = 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.44", "l": "\"galacturonokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33099", "l": "acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624494", "l": "RAF1 binds p21 RAS:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160149", "l": "tRNA pseudouridine(65) synthase activity", "d": ["Catalysis of the reaction: uridine(65) in tRNA = pseudouridine(65) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15461", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202111", "l": "AKT1 phosphorylates eNOS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68251", "l": "L-tyrosine(in) + Na(+)(in) <=> L-tyrosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015228", "l": "coenzyme A transmembrane transporter activity", "d": ["Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649655", "l": "NEIL1 recognizes and binds DHU-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13039", "l": "ITP + NH4(+) => ATP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54061", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2Z,6E)-hedycaryol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0015165", "l": "pyrimidine nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.58", "l": "\"russellysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25278", "l": "3',5'-cyclic AMP + H2O => AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836702", "l": "PKR inhibitors bind PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47563", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033222", "l": "xylose binding", "d": ["Binding to the D- or L-enantiomer of xylose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29840", "l": "L-idonate + NADP(+) => 2-dehydro-L-idonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72762", "l": "anthocyanin A6 + malonyl-CoA <=> anthocyanin A8 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34126", "l": "3,5,7-trioxododecanoyl-CoA <=> CoA + H(+) + olivetolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73161", "l": "FMN(in) + NAD(+)(out) => FMN(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57221", "l": "GTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68710", "l": "diphosphate + linalool => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395992", "l": "p-T,4S-IRF3 is dimerized (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222491", "l": "Lactoferrin scavenges iron ions (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389352", "l": "Translocation of Vav1 to CD28 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41197", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30067", "l": "betaine aldehyde + H2O + NADP(+) = glycine betaine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209960", "l": "Diiodinated tyrosine can be deiodinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189439", "l": "ALAD condenses 2 dALAs to form PBG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44923", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH <=> (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10844", "l": "oxaloacetate + pyridoxamine = L-aspartate + pyridoxal", "d": [], "t": []}, {"i": "EC:2.6.1.31", "l": "\"pyridoxamine--oxaloacetate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68404", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) = 2-oxoheptanedioate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444171", "l": "Receptor FFAR2 binds carboxylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26240", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56921", "l": "a medium chain fatty acid + ATP + H(+) => a medium-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665707", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703438", "l": "FLT3 fusions phosphorylate GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675431", "l": "PP2A dephosphorylates RAF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47273", "l": "monoanhydrobacterioruberin => bisanhydrobacterioruberin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228407", "l": "tetX HC:LC binds target cell-surface gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683840", "l": "SFTPB gene produces pro-SFTPB protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25802", "l": "3-acetamidopropanal + H2O2 + spermidine => H2O + N(1)-acetylspermine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "43.444569111645905", "identifiers": [{"i": "GO:0060089", "l": "molecular transducer activity", "d": ["A compound molecular function in which an effector function is controlled by one or more regulatory components."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11494", "l": "(R)-1-aminopropan-2-yl phosphate + CO2 => H(+) + O-phospho-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70002", "l": "L-threonine(in) + Na(+)(in) <=> L-threonine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955844", "l": "RBKS phosphorylates ribose to R5P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015130", "l": "mevalonate transmembrane transporter activity", "d": ["Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873921", "l": "Binding of STAT1 to p-IFNGR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948757", "l": "AKT phosphorylates MKRN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37587", "l": "2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875451", "l": "MET phosphorylates CBL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806613", "l": "Keratin tetramers bind to form unit length filaments (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42524", "l": "uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.23", "l": "\"23S rRNA pseudouridine(1911/1915/1917) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791177", "l": "Expression of KLHDC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35558", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31121", "l": "(2E)-2-methylbut-2-enoyl-CoA + H2O => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004558", "l": "alpha-1,4-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066785", "l": "Retranslocation of DHA back to ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59247", "l": "3''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37832", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15150", "l": "O2 + pyridoxine 5'-phosphate => H2O2 + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19798", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56868", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.273", "l": "\"diglucosylglycerate octanoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39367", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983144", "l": "Transport of Antigen peptide in to ER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60310", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411383", "l": "NLK phosphorylates TCF/LEF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840949", "l": "ARSA removes sulfate from SM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44374", "l": "Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide => Cr(6+) + 2 NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140819", "l": "UDP-beta-L-arabinofuranose transporter activity", "d": ["Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13123", "l": "3-phosphoshikimate + ADP + H(+) => ATP + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23421", "l": "alpha,alpha-trehalose 6-phosphate + H2O => alpha,alpha-trehalose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26455", "l": "NADP(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53897", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62461", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036004", "l": "GAF domain binding", "d": ["Binding to a GAF protein domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37340", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O => (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013109", "l": "RHOC GEFs activate RHOC (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21404", "l": "chloride + O2 = chlorite", "d": [], "t": []}, {"i": "EC:1.13.11.49", "l": "\"chlorite O2-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14570", "l": "propane-1,2-diol => H2O + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22328", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61752", "l": "steviolbioside + UDP-alpha-D-glucose = H(+) + rebaudioside B + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32329", "l": "H(+) + NADH + zerumbone => 10-hydroxy-alpha-humulene + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13629", "l": "(1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.243", "l": "\"carveol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047686", "l": "arylsulfate sulfotransferase activity", "d": ["Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17039", "l": "H(+) + indole-3-acetaldehyde + NADPH => indole-3-ethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25648", "l": "(2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64151", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GalNAc-R + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380782", "l": "STAT binds to the active receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173725", "l": "C9 binds C5b:C6:C7:C8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74213", "l": "L-threonine + tRNA(Lys) => H2O + L-threonyl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389919", "l": "Grb2 binds pBTLA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18522", "l": "licodione + S-adenosyl-L-methionine => 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69152", "l": "Removal of remaining Flap (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11952", "l": "3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate", "d": [], "t": []}, {"i": "EC:5.3.1.22", "l": "\"hydroxypyruvate isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30834", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36037", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77176", "l": "5-hydroxymethyl-dCMP + H(+) + H2O => 5-hydroxymethyl-dUMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189488", "l": "UROS transforms HMB to URO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809707", "l": "MTMR12 binds MTMR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227891", "l": "TRAF3/or TRAF6 interacts with IPS-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49441", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA => (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659899", "l": "Defective SI does not hydrolyze maltotriose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14598", "l": "a CDP-1,2-diacyl-sn-glycerol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680836", "l": "NS5B binds ribavirin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0043176", "l": "amine binding", "d": ["Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21988", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside = 4'''-demalonylsalvianin + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.172", "l": "\"anthocyanin 5-O-glucoside 6'''-O-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15111", "l": "(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH => 2-dehydro-3-deoxy-D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20499", "l": "an N-acetyl-2-arylethylamine + CoA + H(+) => a 2-arylethylamine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382061", "l": "Extracellular processing of novel PDGFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007926", "l": "ATRX binds DAXX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46163", "l": "a quinone + H(+) + NADH <=> a quinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110319", "l": "Elongation by POLH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193700", "l": "p75NTR ICD signals to NF-kB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18067", "l": "ADP + H(+) + phosphate + phosphonate(in) => ATP + H2O + phosphonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191654", "l": "c-src associates with Cx43 in gap junctions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835121", "l": "Heparin binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805122", "l": "AURKB binds TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55145", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68256", "l": "L-cystine(in) + Na(+)(in) = L-cystine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17979", "l": "a long-chain fatty acid + 3 H(+) + 2 NADH => a long-chain primary fatty alcohol + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682598", "l": "ATM phosphorylates HERC2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61355", "l": "ATP + H2O + riboflavin(in) <=> ADP + H(+) + phosphate + riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805399", "l": "TAF1 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655170", "l": "RCHY1 monoubiquitinates POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33141", "l": "L-alanine(in) + L-aspartate(out) => L-alanine(out) + L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002460", "l": "P4HB binds Collagen chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15732", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004349", "l": "glutamate 5-kinase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56650", "l": "3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000074", "l": "TCN2 binds RCbl in the circulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74814", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28907", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) = 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50199", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57337", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009072", "l": "STAT3 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047295", "l": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141437", "l": "Formation of the MCC complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605717", "l": "GM2A binds and mobilizes ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27886", "l": "2',3'-cyclophospho-AMP + H2O = 3'-AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62738", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64803", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37453", "l": "1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203567", "l": "palmitoylation of eNOS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800816", "l": "TP53 or TP63 stimulates PERP gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865320", "l": "CBFB binds RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39735", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.6", "l": "\"nucleoside diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549533", "l": "Expression of PERIOD-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674385", "l": "p-T,Y MAPKs dimerize (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647746", "l": "EML4 trimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59973", "l": "decanoyl-CoA + L-seryl-[protein] => CoA + O-decanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168947", "l": "Ligand binds to TLR10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38273", "l": "3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640195", "l": "RRAGA,B hydrolyzes GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209107", "l": "Further phosphorylation of APC by DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33920", "l": "H(+) + lanosterol + NADPH => 24,25-dihydrolanosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035241", "l": "protein-arginine omega-N monomethyltransferase activity", "d": ["Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52096", "l": "9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173542", "l": "SMURF2 ubiquitinates SMAD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11510", "l": "3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018594", "l": "MECP2 binds LBR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22643", "l": "NADP(+) + sphinganine <=> 3-oxosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189488", "l": "UROS transforms HMB to URO3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60946", "l": "H(+) + isorhamnetin + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40215", "l": "FADH2 + O2 = FAD + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74740", "l": "Binding of SHC1 to insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694462", "l": "ABHD6,12 hydrolyse 3AG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33276", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19769", "l": "phaseollidin hydrate = H2O + phaseollidin", "d": [], "t": []}, {"i": "EC:4.2.1.97", "l": "\"phaseollidin hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24303", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) <=> 2 cob(II)yrinate a,c diamide + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703442", "l": "Phosphorylated FLT3 fusions bind GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28646", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-zingiberene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426566", "l": "Interaction of DAP12 and CLM7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19378", "l": "NADP(+) + reduced riboflavin => 2 H(+) + NADPH + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975098", "l": "MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19938", "l": "glycine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202713", "l": "CD84 homodimerises (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56248", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46368", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71207", "l": "iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514790", "l": "Elastin degradation by MMP14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805470", "l": "AMPK phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010284", "l": "lariciresinol reductase activity", "d": ["Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003848", "l": "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51016", "l": "7,8-dihydroneopterin 3'-phosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.59", "l": "\"dihydroneopterin phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70227", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA = (E)-2-benzylidenesuccinyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.180", "l": "\"(E)-benzylidenesuccinyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74354", "l": "2 (S)-lactate(in) + prostaglandin E3(out) <=> 2 (S)-lactate(out) + prostaglandin E3(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68843", "l": "(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052914", "l": "16S rRNA (guanine(1207)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61129", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671702", "l": "AP1G2 binds HGS and CHMP2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18418", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190256", "l": "FGFR1c binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64839", "l": "2-phenylethanol + acetyl-CoA <=> CoA + phenethyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61921", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O => (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374664", "l": "Phosphorylation and activation of Ezrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111962", "l": "PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44678", "l": "a diacylglycerol + an all-trans-retinyl ester => a triacyl-sn-glycerol + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38147", "l": "carbon disulfide + H2O = carbonyl sulfide + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371527", "l": "HSF1 trimer translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52309", "l": "2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647994", "l": "RAS proteins are depalmitoylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63026", "l": "(13Z)-docosenoate + NH4(+) => (13Z)-docosenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13991", "l": "alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029273", "l": "PI3K binds to p-6Y-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000120", "l": "CBLIF binds RCbl (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68816", "l": "(2Z,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67932", "l": "ATP + desmosterol(in) + H2O = ADP + desmosterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0031811", "l": "G protein-coupled nucleotide receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193665", "l": "MYD88 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021050", "l": "HSBP1 oligomer binds ESRs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74484", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 => (-)-cyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.88", "l": "\"tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669893", "l": "KIT binds type I TKIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35966", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A <=> fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54741", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62348", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449117", "l": "TXLNA (IL14) binds syntaxin1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749253", "l": "Formation of MCM2-7 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010698", "l": "acetyltransferase activator activity", "d": ["Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003957", "l": "NAD(P)+ transhydrogenase (B-specific) activity", "d": ["Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484822", "l": "Kinetochore assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080047", "l": "GDP-L-galactose phosphorylase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + phosphate = beta-L-galactose-1-phosphate + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57768", "l": "2-nitrotoluene + NADH + O2 = 3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16735", "l": "CO2 + orcinol => H(+) + orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696275", "l": "RND2 binds GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31659", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376140", "l": "Ena/VASP proteins bind ROBO1:SLIT2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37434", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0016160", "l": "amylase activity", "d": ["Catalysis of the hydrolysis of amylose or an amylose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015105", "l": "arsenite transmembrane transporter activity", "d": ["Enables the transfer of arsenite from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432054", "l": "Aquaporin-1 passively transports water out of cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47731", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051433", "l": "BH2 domain binding", "d": ["Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592240", "l": "Formation of NRF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047345", "l": "ribose-5-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ADP + H+ = ADP-ribose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981832", "l": "NMUR2 binds neuromedin-S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57804", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031804", "l": "type 7 metabotropic glutamate receptor binding", "d": ["Binding to a type 7 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874718", "l": "TTPA binds alpha-TOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168400", "l": "iE-DAP elicits a NOD1 response (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23161", "l": "L-rhamnopyranose => L-rhamnulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44545", "l": "a fatty acid(out) + ATP + H2O => a fatty acid(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031765", "l": "type 2 galanin receptor binding", "d": ["Binding to a type 2 galanin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197698", "l": "Src phosphorylate WASP,N-WASP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38137", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23836", "l": "D-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.41", "l": "\"D-methionine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46218", "l": "3beta-hydroxypregn-4-ene-20-one + NADP(+) => H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53091", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67868", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43007", "l": "H(+) + O-carbamoyl-L-serine <=> 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25639", "l": "2 H(+) + NADH + sulfoacetate => H2O + NAD(+) + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11702", "l": "H2O + NADP(+) + testosterone acetate => H(+) + NADPH + O2 + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76291", "l": "Na(+)(out) + xanthine(out) = Na(+)(in) + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196773", "l": "COASY phosphorylates DP-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.200", "l": "\"exo-chitinase (non-reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660615", "l": "Defective RB1 does not translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757454", "l": "ST translocates from cytosol to mitochondrial matrix of hepatocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57960", "l": "dimethyl sulfide + H(+) + NADH + O2 = dimethyl sulfoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804379", "l": "PRMT5 binds TTC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25978", "l": "(5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75912", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51706", "l": "4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthohumol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016230", "l": "sphingomyelin phosphodiesterase activator activity", "d": ["Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050051", "l": "leukotriene-B4 20-monooxygenase activity", "d": ["Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75506", "l": "glycocholate(out) + n H(+)(out) <=> glycocholate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018568", "l": "3,4-dihydroxyphenanthrene dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003883", "l": "CTP synthase activity", "d": ["Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77687", "l": "a ganglioside GD1a (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GalNAc-GD1a (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166753", "l": "Conversion of C4 into C4a and C4b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624948", "l": "KIF17 enters the cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016622", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome."], "t": []}, {"i": "EC:1.2.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380930", "l": "Phosphorylated AMPK binds AMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661161", "l": "USP9X:SNCA dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45034", "l": "4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite => 4 Fe(III)-[cytochrome c] + H2O + hydroxylamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77349", "l": "L-aspartate + pyruvate => L-alanine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29978", "l": "2'-deoxycytidine(in) + H(+)(in) <=> 2'-deoxycytidine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112429", "l": "Formation of FACT complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22826", "l": "2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34048", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 => 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987214", "l": "p-STAT3 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59119", "l": "[protein]-dithiol + O2 <=> [protein]-disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250930", "l": "B-WICH recruits histone acetyltransferases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0004812", "l": "aminoacyl-tRNA ligase activity", "d": ["Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP."], "t": []}, {"i": "EC:6.1.1.-", "l": "\"Ligases forming aminoacyl-tRNA and related compounds\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73651", "l": "CTP(out) = CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37192", "l": "2',3'-cyclophospho-AMP + H2O => adenosine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21548", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] = acetate + L-lysyl-[alpha-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14050", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56158", "l": "(12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31574", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16437", "l": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204303", "l": "MRE11 binds cytosolic DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74305", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH => 12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106310", "l": "protein serine kinase activity", "d": ["Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34798", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047302", "l": "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69053", "l": "RFC binding displaces Pol Alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12223", "l": "H2O + L-leucine + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852010", "l": "BTNL2 binds activated T cells surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19403", "l": "formaldehyde + H(+) + NADH => methanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730841", "l": "Phosphorylation and activation of VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68022", "l": "(2E)-geraniol + phosphate => (2E)-geranyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33456", "l": "4alpha-carboxyzymosterol + NADP(+) => CO2 + NADPH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57912", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) = H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64694", "l": "2-methylpropanal + H(+) + NADH => isobutanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849463", "l": "PTK6 phosphorylates SFPQ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48472", "l": "a ganglioside GT1a + H2O = a ganglioside GD1a + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20554", "l": "(R)-methylmalonyl-CoA => (S)-methylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434650", "l": "MATEs mediate extrusion of xenobiotics (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39945", "l": "a 1,2-diacylglycerol + CoA => a 1-acylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9619756", "l": "NR1H2 binds ABCA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951442", "l": "CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32482", "l": "2 iodide + L-tyrosine + 2 NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21476", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.34", "l": "\"1,3-beta-glucan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033713", "l": "choline:oxygen 1-oxidoreductase activity", "d": ["Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088134", "l": "PLK1 phosphorylates FOXM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984226", "l": "PLK1 phosphorylates NEK9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70096", "l": "(R)-5-methyl-tetronate + o-quinone methide => peniphenone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047233", "l": "N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30950", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-gamma-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32439", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.39", "l": "\"epi-isozizaene 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19907", "l": "dehydrospermidine + H(+) + NADH => NAD(+) + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60231", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.28", "l": "\"glucosyl-DNA beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30262", "l": "2 a menaquinol + n H(+)(in) + O2 <=> 2 a menaquinone + n H(+)(out) + 2 H2O(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198714", "l": "ERK5 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41142", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018572", "l": "EGFR phosphorylates NOTCH3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695949", "l": "SPHK2 phosphorylates sphingoid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31166", "l": "(3S)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.13", "l": "\"sterol esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047075", "l": "2,5-dihydroxypyridine 5,6-dioxygenase activity", "d": ["Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684008", "l": "NBN binds KPNA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30826", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19387", "l": "H(+) + raucaffricine + UDP => UDP-alpha-D-glucose + vomilenine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036312", "l": "phosphatidylinositol 3-kinase regulatory subunit binding", "d": ["Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75543", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] = (2E)-decenoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24729", "l": "N-demethylindolmycin + S-adenosyl-L-methionine <=> H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34529", "l": "(S)-3-amino-3-phenylpropanoate => L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666435", "l": "VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37439", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26198", "l": "H2O + melamine => ammeline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13323", "l": "3-methyl-2-oxobutanoate + CO2 + NADH => (R)-3,3-dimethylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36684", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] => CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44869", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol => 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12780", "l": "2-amino-4-hydroxypteridine + O2 <=> 2-amino-4,7-dihydroxypteridine + chemical entity", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25910", "l": "an aldose + H2O2 => an alditol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31871", "l": "(S)-2,3-epoxysqualene = alpha-seco-amyrin", "d": [], "t": []}, {"i": "EC:5.4.99.52", "l": "\"alpha-seco-amyrin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202966", "l": "Caspase mediated cleavage of HIP-55 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102002", "l": "valine N-monooxygenase (oxime forming) activity", "d": ["Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ = (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004523", "l": "RNA-DNA hybrid ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56725", "l": "AH2 + all-trans-beta-carotene + O2 => 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834807", "l": "ILF3 binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27458", "l": "3-iodo-L-tyrosine + iodide + NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33470", "l": "5-dehydroepisterol + H(+) + NADPH + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29076", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 => CO2(out) + H(+)(out) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.4", "l": "\"type II site-specific deoxyribonuclease\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36790", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36270", "l": "caffeine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22866", "l": "D-lysine => L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67505", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685011", "l": "ATR activation at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16194", "l": "an (R)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56807", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64943", "l": "dGDP + H2O <=> dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26220", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63696", "l": "SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174202", "l": "Degradation of multiubiquitinated Securin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56260", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose = 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72481", "l": "citrate(in) + trans-aconitate(out) => citrate(out) + trans-aconitate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17146", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) => 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68392", "l": "H2O + peracetic acid = acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66142", "l": "CoA + H(+) + N-acetyloctopamine => acetyl-CoA + octopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65446", "l": "CoA + hexyl butanoate => butanoyl-CoA + hexan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14222", "l": "H2O + monomethyl sulfate => H(+) + methanol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052877", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor."], "t": []}, {"i": "EC:1.4.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648883", "l": "p-T-EIF2AK1:ferriheme dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876484", "l": "NPC2 transfers CHOL to NPC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70374", "l": "3-oxosphinganine + decanoyl-CoA <=> CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73904", "l": "ATP + ethanolamine + L-glutamate => ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36237", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63570", "l": "beta-casomorphin-6 + L-isoleucine => beta-casomorphin-7 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31310", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54609", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14999", "l": "deoxylimononate D-ring-lactone + H(+) => deoxylimonoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420131", "l": "The PACAP receptor binds PACAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55385", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate => 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41062", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611852", "l": "ADRB3 bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190829", "l": "Lysosomal degradation of gap junction plaques (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33186", "l": "citrate(in) <=> citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50376", "l": "a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38494", "l": "2-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351948", "l": "Mitochondrial recruitment of Drp1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444523", "l": "Formation of MSH1:PMS2 Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19776", "l": "NADP(+) + sn-glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102622", "l": "linuron hydrolase activity", "d": ["Catalysis of the reaction: linuron + H2O = N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34564", "l": "CDP-alpha-D-abequose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39545", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102389", "l": "polyprenol reductase activity", "d": ["Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12262", "l": "ADP + H(+) + NADPH => ATP + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623365", "l": "Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106324", "l": "(S)-limonene 1,2-monooxygenase NADH activity", "d": ["Catalysis of the reaction: (4S)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4S)-limonene-1,2-epoxide."], "t": []}, {"i": "RHEA:26089", "l": "(4S)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69818", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0015378", "l": "sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034084", "l": "steryl deacetylase activity", "d": ["Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004913", "l": "interleukin-4 receptor activity", "d": ["Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77604", "l": "2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) => 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169680", "l": "IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070038", "l": "rRNA (pseudouridine-N3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53847", "l": "glycochenodeoxycholate + NAD(+) <=> 7-oxoglycolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314678", "l": "ASA- acetylates PTGS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52065", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71247", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31629", "l": "10-deoxymethymycin + dTDP + H(+) => 10-deoxymethynolide + dTDP-alpha-D-desosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801101", "l": "RABGGTA binds RABGGTB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168640", "l": "Ubiquitinated IkB is degraded (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50539", "l": "prostaglandin E2 <=> H2O + prostaglandin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67762", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0000217", "l": "DNA secondary structure binding", "d": ["Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42409", "l": "(2R)-2-phosphoglycerate + ATP => (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20797", "l": "aldehydo-D-ribose => D-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607753", "l": "CARD9 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114352", "l": "Sequestration of tBID by BCL-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12145", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose => cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685230", "l": "CHEK1 phosphorylates RAD51 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56631", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O <=> chloride + 2 H(+) + maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47076", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29655", "l": "L-cysteine(in) = L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25186", "l": "1,2-dichloroethane + H2O => 2-chloroethanol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43974", "l": "H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40142", "l": "(9Z)-octadecenoyl-CoA + H2O <=> (9Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51160", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45684", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) = N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22655", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O <=> 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31054", "l": "(3R)-beta-leucine + H2O + NAD(+) <=> 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202437", "l": "Phosphorylation of CARMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18366", "l": "(R)-malate + NAD(+) => CO2 + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65827", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72665", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12030", "l": "H(+) + N-carbamoyl-L-aspartate => H2O + L-5-carboxymethylhydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56182", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2 => 8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.2", "l": "\"NAD(P)H oxidase (H2O-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50871", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601924", "l": "Primary piRNA transcript translocates from nucleoplasm to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12686", "l": "2 mycothiol + NADP(+) => H(+) + mycothione + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0097200", "l": "cysteine-type endopeptidase activity involved in execution phase of apoptosis", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047738", "l": "cellobiose phosphorylase activity", "d": ["Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23216", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.58", "l": "\"benzoyl-CoA 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193684", "l": "p62 recruits an atypical PKC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807106", "l": "PTEN undergoes monoubiquitination (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72766", "l": "anthocyanin A10 + malonyl-CoA <=> anthocyanin A11 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75059", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019191", "l": "cellobiose transmembrane transporter activity", "d": ["Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863494", "l": "ASICs bind STOML3, (STOM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549304", "l": "OCT3 mediates renal clearance of organic cations (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114553", "l": "Activation of conventional Protein Kinase C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029451", "l": "Activation of RAC1 by VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071535", "l": "RING-like zinc finger domain binding", "d": ["Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67213", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62756", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40508", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33606", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730842", "l": "PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202713", "l": "CD84 homodimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57743", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) <=> a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102735", "l": "trihydroxybenzophenone synthase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74980", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) => (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14660", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14854", "l": "4-chlorobenzoyl-CoA + H2O => 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3095889", "l": "MMACHC dealkylates RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34414", "l": "cannabigerolate + O2 <=> cannabidiolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014342", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25928", "l": "3-methylquinoline + A + H2O = 3-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51469", "l": "(R)-lactate + a quinone => a quinol + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733545", "l": "Bile salts and acids bind ALB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202969", "l": "Caspase mediated cleavage of beta-catenin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76862", "l": "3-aminopentane + H2O + NAD(+) <=> H(+) + NADH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683774", "l": "p-T68-CHEK2 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66248", "l": "CoA + IC-asc-C9-AMP = AMP + H(+) + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103106", "l": "brassinolide 23-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose = brassinolide-23-O-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60856", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17881", "l": "H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate", "d": [], "t": []}, {"i": "EC:3.10.1.1", "l": "\"N-sulfoglucosamine sulfohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005094", "l": "Rho GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64902", "l": "H(+) + phosphate + UDP => H2O + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45719", "l": "H2O + N,N,N-trimethylglycyl-CoA <=> CoA + glycine betaine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389762", "l": "Phosphorylation of PD-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53224", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19374", "l": "H2O + L-saccharopine + NADP(+) => 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655193", "l": "KIAA0101 double monoubiquitination (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11936", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + trans-resveratrol", "d": [], "t": []}, {"i": "EC:2.3.1.95", "l": "\"trihydroxystilbene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-921155", "l": "p-STAT5 dissociates from the receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71113", "l": "L-phenylalanine(in) + S-methylmercury-L-cysteine(out) => L-phenylalanine(out) + S-methylmercury-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55558", "l": "an oxoeicosatetraenoate + H2O => a hydroperoxyeicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39494", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71347", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) = chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033968", "l": "glutaryl-7-aminocephalosporanic-acid acylase activity", "d": ["Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44519", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20997", "l": "(2Z,4E)-2-aminomuconate + H2O => (3E)-2-oxohex-3-enedioate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849094", "l": "ARHGAP35 binds RASA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66028", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine = (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.379", "l": "\"[methyl coenzyme M reductase]-L-arginine C-5-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67287", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39799", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24828", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62104", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23107", "l": "D-arabinose 5-phosphate <=> D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70659", "l": "H(+)(in) + N,N-dimethylglycine(in) = H(+)(out) + N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52748", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O = 2 isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64517", "l": "2-hydroxyethane-1-sulfonate + NAD(+) => H(+) + NADH + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30754", "l": "ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40430", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428123", "l": "KDSR reduces 3-ketosphingoid (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39910", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose <=> dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36884", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54868", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH = butanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32547", "l": "(2E)-geranyl diphosphate = (1R,5R)-sabinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.110", "l": "\"(+)-sabinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47594", "l": "a ganglioside GP1c (d18:1(4E)) + CMP + H(+) => a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030778", "l": "columbamine O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H+ + palmatine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61057", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674018", "l": "BRAP binds RAS:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63412", "l": "2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.1", "l": "\"hexokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682709", "l": "LGI4 binds ADAM22,23,11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22758", "l": "a long-chain fatty aldehyde + H2O2 => a long-chain primary fatty alcohol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.12", "l": "\"xanthan lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58537", "l": "glycine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0030561", "l": "RNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67743", "l": "N-acetyl-beta-neuraminate <=> aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10285", "l": "L-leucine => (3R)-beta-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63139", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57364", "l": "H2O + NADH = (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28321", "l": "scutellarein + UDP-alpha-D-glucuronate <=> scutellarin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28737", "l": "H(+)(out) + spermidine(in) => H(+)(in) + spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435244", "l": "PECAM1 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69129", "l": "glyoxylate + L-leucine => 4-methyl-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28739", "l": "Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62984", "l": "H2O + hexadecanamide = hexadecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0000171", "l": "ribonuclease MRP activity", "d": ["Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11154", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+) => 5-pyridoxate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68611", "l": "Formation of ORC(1-5) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54968", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59220", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.25", "l": "\"2-hydroxy-6-oxohepta-2,4-dienoate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72287", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) = 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619478", "l": "CAMKK2 phosphorylates AMPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39137", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682010", "l": "ATG10:ATG12 binds ATG5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374701", "l": "Phosphorylation of DCC by Fyn (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707516", "l": "FeHM dissociates from MetHb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114671", "l": "vWF binds to collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46038", "l": "dCMP + H(+) + UDP => 2'-deoxycytidine + UTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471322", "l": "Beta-defensins are secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31046", "l": "(S)-2-methyl-3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + methylmalonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57171", "l": "(R)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640195", "l": "RRAGA,B hydrolyzes GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.84", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903879", "l": "11beta-hydroxyprogesterone binding", "d": ["Binding to 11beta-hydroxyprogesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29205", "l": "dimethyl sulfide + H2O + menaquinone-8 => dimethyl sulfoxide + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52442", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67395", "l": "2-oxo-ATP + H2O <=> 2-oxo-AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12590", "l": "a ganglioside GM2 (d18:1(4E)) + H(+) + UDP => a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390641", "l": "ADRA1A,B,D bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693598", "l": "ATM phosphorylates NBN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019960", "l": "C-X3-C chemokine binding", "d": ["Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48976", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + pyocyanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25365", "l": "H(+) + momilactone A + NADH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38169", "l": "CoA + hexadecanyl hexadecanoate => hexadecan-1-ol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21252", "l": "(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.2", "l": "\"L-2-hydroxyglutarate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69396", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247844", "l": "WNT ligands traffic to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375302", "l": "Kinetochore capture of astral microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48784", "l": "D-erythrulose 4-phosphate = D-erythrose 4-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.34", "l": "\"D-erythrulose 4-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018608", "l": "1-indanone dioxygenase activity", "d": ["Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013159", "l": "CDC42 GEFs activate CDC42 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654514", "l": "KAL1 binds FGFR1c (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44111", "l": "H2O + heptanal + NAD(+) <=> 2 H(+) + heptanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32599", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788622", "l": "p-Y-STATs dimerize (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15321", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.93", "l": "\"3,9-dihydroxypterocarpan 6a-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753634", "l": "GGT dimers hydrolyse APAP-SG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9656244", "l": "DRD2 binds DA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48924", "l": "a ganglioside GM4 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25576", "l": "3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX", "d": [], "t": []}, {"i": "EC:1.3.3.4", "l": "\"protoporphyrinogen oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678854", "l": "S1PR1 binds S1PR1 agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48526", "l": "a ganglioside GQ1c + N-acetylneuraminate => a ganglioside GP1c + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362465", "l": "GHBP binds GHR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875431", "l": "LRIG1 undergoes ubiquitination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004470", "l": "malic enzyme activity", "d": ["Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666008", "l": "SCAI binds SRF:MKL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22945", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683712", "l": "3a translocates to the ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41091", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875661", "l": "GGA3 associates with activated MET receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358512", "l": "MLH1:PMS2 makes single strand incision near  insertion/deletion loop of 2 bases or more (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698844", "l": "MLKL binds HSP90:CDC37 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20865", "l": "alpha,alpha-trehalose 6-phosphate + phosphate => beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.196", "l": "\"L-ornithine N(5)-monooxygenase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005456", "l": "CMP-N-acetylneuraminate transmembrane transporter activity", "d": ["Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109700", "l": "AKT2 binds PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.111", "l": "\"2-oxoglutaramate amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000170", "l": "sphingosine hydroxylase activity", "d": ["Catalysis of the hydroxylation of sphingolipid long chain bases."], "t": []}, {"i": "REACT:R-HSA-428260", "l": "DEGS2 oxygenates dihydroceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19618", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977605", "l": "Factor H displaces Bb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18365", "l": "(R)-malate + NAD(+) = CO2 + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.1.83", "l": "\"D-malate dehydrogenase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38901", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10710", "l": "diphosphate + GDP-D-glucose => alpha-D-glucose 1-phosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74746", "l": "kaempferol + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015577", "l": "galactitol transmembrane transporter activity", "d": ["Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose."], "t": []}, {"i": "RHEA:33143", "l": "galactitol(in) = galactitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34934", "l": "glutathioselenol + NADPH <=> glutathione + hydrogenselenide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32409", "l": "(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2S,4S)-neoisodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102580", "l": "cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose = cyanidin 3-O-beta-D-sambubioside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30028", "l": "D-glyceraldehyde + H(+) + NADH => glycerol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450088", "l": "GLUT1 tetramer binds 4xATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001602", "l": "pancreatic polypeptide receptor activity", "d": ["Combining with pancreatic polypeptide PP to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36171", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:2.5.1.26", "l": "\"alkylglycerone-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22699", "l": "AH2 + androst-4-ene-3,17-dione + O2 <=> A + H2O + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036188", "l": "abieta-7,13-dien-18-al dehydrogenase activity", "d": ["Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754974", "l": "ADK phosphorylates RBV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59645", "l": "D-xylobiono-1,5-lactone + H2O => D-xylobionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332235", "l": "CBL binds TGFBR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66541", "l": "7-dehydrocholesterol + A + H2O => AH2 + cholesta-5,7-dien-3beta,25-diol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33154", "l": "(R)-dihydrolipoamide + acetyl-CoA <=> (R)-S(6)-acetyldihydrolipoamide + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389523", "l": "BTLA interacts with HVEM (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873918", "l": "Transphosphorylation of JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641205", "l": "RSPO:LGR binds ZNRF3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381644", "l": "ER calcium channels open in response to activated PKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75221", "l": "H(+) + L-fuconate => H2O + L-fucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76805", "l": "1-hydroxypentan-2-one + H(+) + NADH + NH4(+) => 2-aminopentan-1-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58879", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14046", "l": "1-carboxyvinyl carboxyphosphonate + H(+) => 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483107", "l": "GPETA is hydrolyzed to ETA and G3P by GPCPD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62329", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51576", "l": "phloretin + UDP-alpha-D-glucose = H(+) + phlorizin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.357", "l": "\"phlorizin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62748", "l": "H2O + lovastatin = (S)-2-methylbutanoate + H(+) + monacolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12124", "l": "4-coumaroyl-CoA + shikimate = CoA + trans-4-coumaroylshikimate", "d": [], "t": []}, {"i": "EC:2.3.1.133", "l": "\"shikimate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936642", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK1 (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13177", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.29", "l": "\"5-dehydro-2-deoxyphosphogluconate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51294", "l": "a quinol + L-methionyl-(S)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52745", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O => alpha-isomaltosyl-(1->3)-isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75636", "l": "(9Z)-octadecenoate + O2 => 10-hydroperoxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65213", "l": "(2E)-dodecenoyl-CoA + H2O => (2E)-dodecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804383", "l": "PRMT5 methylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17322", "l": "L-tryptophan + S-adenosyl-L-methionine => 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35091", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:6.3.2.40", "l": "\"cyclopeptine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68199", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA <=> 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990409", "l": "adrenomedullin binding", "d": ["Binding to adrenomedullin (AM)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44994", "l": "CoA + O-2-methylbutanoyl-(R)-carnitine => (R)-carnitine + 2-methylbutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69123", "l": "glyoxylate + L-phenylalanine <=> 3-phenylpyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15200", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29457", "l": "D-serine(out) => D-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73675", "l": "ADP(out) + dAMP(in) + H(+)(out) = ADP(in) + dAMP(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391867", "l": "Fyn binds NCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134800", "l": "STING dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032931", "l": "histone H3K56 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68795", "l": "alpha-NAD(+) + H2O <=> ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49773", "l": "glycine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48264", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] = H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22816", "l": "alpha-D-xylose = alpha-D-xylulofuranose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375160", "l": "NCAM1 binds to ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73069", "l": "an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] => an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13464", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 <=> 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362416", "l": "Frataxin binds iron (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050809", "l": "diazepam binding", "d": ["Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835189", "l": "NCK1 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71945", "l": "(S)-malate(in) + 3 Na(+)(in) => (S)-malate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928615", "l": "EFNBs bind SFKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983158", "l": "Trimming of peptides in ER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74564", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate => aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10324", "l": "an L-glycol + NADP(+) = a 2-hydroxycarbonyl + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68460", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid = a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.15", "l": "\"steroid sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671868", "l": "Phosphorylated LEPR Binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193695", "l": "IRAK interacts with TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45090", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247847", "l": "WLS is endocytosed to the early endosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25619", "l": "diphosphate + terpentetriene => terpentedienyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29554", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73810", "l": "GDP + S-adenosyl-L-methionine <=> N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48681", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) => a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2981040", "l": "COLEC12:ligand is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183055", "l": "Binding of CBL to EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166214", "l": "FA anion flip-flops to the opposite surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29542", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19994", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578663", "l": "MSH3 variant:MSH2-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.30", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987007", "l": "p-STAT1 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856945", "l": "PP2A methylation by LCMT1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031693", "l": "alpha-1D adrenergic receptor binding", "d": ["Binding to an alpha-1D adrenergic receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10729", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106099", "l": "2-keto-3-deoxy-L-rhamnonate aldolase activity", "d": ["Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755304", "l": "MUL1 ubiquitinates UBXN7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40772", "l": "(20S)-ginsenoside Rg1 + H2O => (20S)-ginsenoside F1 + D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46731", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34083", "l": "a (3R)-3-hydroxyacyl-CoA = a (3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67302", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63076", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55567", "l": "4-hydroxytryptamine + ATP <=> 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53922", "l": "ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein] => ATP + L-threonyl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950271", "l": "sIL27RA translocates from the cytoplasm to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53593", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O => 1-tetradecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047232", "l": "galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59428", "l": "3-hydroxypropanal + H2O + NADP(+) = 3-hydroxypropanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696275", "l": "RND2 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69980", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830804", "l": "N-/O-glycan-sG is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68277", "l": "butanoyl-CoA + L-seryl-[protein] => CoA + O-butanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24184", "l": "4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.55", "l": "\"4,5-dihydroxyphthalate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429441", "l": "SYK activation by SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68741", "l": "7-oxocholesterol + H(+) + NADPH => 7alpha-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36253", "l": "(E)-feruloyl-CoA + AMP + diphosphate => (E)-ferulate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55716", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419083", "l": "Myosin phosphatase inactivation by ROCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65238", "l": "3-methylbutyl acetate + CoA => 3-methylbutanol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37558", "l": "D-kanosamine 6-phosphate + H2O <=> kanosamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0046961", "l": "proton-transporting ATPase activity, rotational mechanism", "d": ["Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18724", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> diphosphate + ent-13-epi-manoyl oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977605", "l": "Factor H displaces Bb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50892", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite = a menaquinol + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19139", "l": "6beta-hydroxyestradiol-17beta + A + H2O => 17beta-estradiol + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66276", "l": "tigogenin + UDP-alpha-D-glucose = H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27905", "l": "caffeine + H2O + ubiquinone-0 <=> 1,3,7-trimethylurate + ubiquinol-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.44", "l": "\"nodavirus endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34435", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.261", "l": "\"4-dimethylallyltryptophan N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71721", "l": "H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in) => H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204303", "l": "MRE11 binds cytosolic DNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016752", "l": "sinapoyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48476", "l": "a ganglioside GT1a (d18:1(4E)) + H2O = a ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757686", "l": "SERPINA6 binds PREDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018856", "l": "benzoyl acetate-CoA ligase activity", "d": ["Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75472", "l": "thiamine diphosphate(out) => thiamine diphosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35148", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58873", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034900", "l": "3-(N-formyl)-formiminopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102535", "l": "ladanein 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: ladanein + S-adenosyl-L-methionine = H+ + salvigenin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950681", "l": "Expression of Lamin-B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13516", "l": "(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30970", "l": "9,9',15-tri-cis-zeta-carotene <=> 9,9'-di-cis-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.17", "l": "\"3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38675", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110219", "l": "Cleavage of thymine by TDG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047047", "l": "oxaloglycolate reductase (decarboxylating) activity", "d": ["Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54940", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696271", "l": "RND1 binds effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009940", "l": "amino-terminal vacuolar sorting propeptide binding", "d": ["Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38489", "l": "(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56594", "l": "a ketone + hydrogen cyanide => a disubstituted aliphatic (S)-hydroxynitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50725", "l": "(E)-4-hydroxyphenylacetaldehyde oxime => (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11812", "l": "H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": [], "t": []}, {"i": "EC:1.8.3.4", "l": "\"methanethiol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733292", "l": "AMY1-3 bind pramlintide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213466", "l": "RIPK3 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60912", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762333", "l": "ANGPTL4 binds to CDH11v (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72957", "l": "2 Na(+)(in) + nicotinate(in) => 2 Na(+)(out) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20080", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164056", "l": "Dephosphorylation of pChREBP (Ser 556) by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39913", "l": "(3S)-2-oxo-3-phenylbutanoate + L-glutamate => (2S,3S)-3-methylphenylalanine + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36316", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH => CoA + hexadecan-1-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433672", "l": "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809764", "l": "SBF1 binds MTMR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.024411547311772", "identifiers": [{"i": "GO:0015932", "l": "nucleobase-containing compound transmembrane transporter activity", "d": ["Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72546", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) <=> 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202500", "l": "Activation of IKK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77527", "l": "hexanal + hydrogen cyanide = (2S)-2-hydroxyheptanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35973", "l": "diphosphate + fumitremorgin B => 12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65999", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) <=> methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030741", "l": "inositol 1-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700184", "l": "Ligand-independent dimerization of point mutants of ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156678", "l": "Activation of Cdc25C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.653457143972261", "identifiers": [{"i": "GO:0004197", "l": "cysteine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61288", "l": "5-deoxy-D-ribose + ATP = 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47646", "l": "4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29035", "l": "ATP + H2O + L-glutamate(out) = ADP + H(+) + L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19487", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP => sphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835358", "l": "p-TARBP2 binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39888", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9844860", "l": "ST3GAL5 transfers NeuNAc to ceramides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141423", "l": "Binding of the MCC complex to the APC/C complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35465", "l": "5alpha-cholest-7-en-3-one + H(+) + NADH => lathosterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73581", "l": "(E,E)-piperoyl-CoA + AMP + H(+) => (E,E)-piperoyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15503", "l": "2-oxoglutarate + H(+) + L-glutamine + NADPH => 2 L-glutamate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41427", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 <=> formate + grixazone A + H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050391", "l": "valine dehydrogenase (NADP) activity", "d": ["Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182286", "l": "Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62980", "l": "(9Z)-hexadecenamide + H2O = (9Z)-hexadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76896", "l": "2-hexyl-5-pentylresorcinol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hexyl-5-(5-hydroxypentyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944215", "l": "Association of procollagen type XX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32611", "l": "(6E)-8-hydroxygeranial + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724745", "l": "PLG(20-810) binds aprotinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13273", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol = 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.19", "l": "\"triglucosylalkylacylglycerol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59936", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17739", "l": "3-dehydroshikimate + H(+) + NADPH => NADP(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29022", "l": "D-galactose(in) + H(+)(in) <=> D-galactose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74335", "l": "O-2-methylbutanoyl-(R)-carnitine(in) = O-2-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20467", "l": "H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP => [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862084", "l": "PILRA,PILRB bind CD99 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796050", "l": "AcK-NFE2L2 binds the KEAP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75424", "l": "(R,S)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33913", "l": "an alkylamine + glyoxylate + H2O2 => an N-alkylglycine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682598", "l": "ATM phosphorylates HERC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203516", "l": "Alpha-1-Microglobulin is cleaved (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373746", "l": "SEMA4D interacts with CD45 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102632", "l": "(S)-nandinine synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612509", "l": "SGK phosphorylates SRF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791060", "l": "Expression of SRPRB (SRP Receptor subunit beta) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16177", "l": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636242", "l": "PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46360", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}, {"i": "EC:1.14.18.4", "l": "\"phosphatidylcholine 12-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60871", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65906", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine => 3-hydroxy-L-kynurenine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.6", "l": "\"galactonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15369", "l": "2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.28", "l": "\"2,3-dihydroxybenzoate 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45293", "l": "2-glyceryl-prostaglandin G2 + AH2 => 2-glyceryl-prostaglandin H2 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665284", "l": "Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853444", "l": "AURKA phosphorylates PHLDA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17339", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+) => catechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58200", "l": "2-oxoglutarate + 6-aminohexanoate = 6-oxohexanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.116", "l": "\"6-aminohexanoate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160915", "l": "Receptor-mediated uptake of HA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60990", "l": "(E)-hex-2-enal + H(+) + NADH => (E)-hex-2-en-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41903", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] <=> 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985201", "l": "ABCE1 binds RNASEL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166015", "l": "Association of LBP with LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70078", "l": "acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433826", "l": "Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688797", "l": "ATXN3 family cleave Ub chains (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0031705", "l": "bombesin receptor binding", "d": ["Binding to a bombesin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373716", "l": "DCC interacting NCK-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15524", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40174", "l": "dodecanoyl-CoA + O2 <=> (2E)-dodecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60882", "l": "a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43551", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62993", "l": "H2O + tetradecamide => NH4(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.86", "l": "\"limulus clotting enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014433", "l": "RHOG GEFs activate RHOG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45997", "l": "a D-alpha-amino acid + a quinone + H2O => a 2-oxocarboxylate + a quinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69068", "l": "RFC dissociates after sliding clamp formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626817", "l": "PKC phosphorylates NCF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371435", "l": "Constitutive phosphorylation by GSK3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59171", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate <=> AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68556", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18834", "l": "4-formylbenzenesulfonate + H2O + NAD(+) => 4-sulfobenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-593685", "l": "Netrin-4 binds DCC/UNC5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452102", "l": "p-STAT5 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71188", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) => 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698762", "l": "FLT3 ITD- and STAT5-dependent NOX4 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42758", "l": "5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40991", "l": "(E)-4-coumaroyl-CoA + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873850", "l": "STARD5 binds DCA, LCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735442", "l": "FOXO4, MEF2C, and NKX2-5 bind the MYOCD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004079", "l": "biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685606", "l": "CLEC2D binds KLRB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42656", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + H(+) + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.97", "l": "\"methylated diphthine methylhydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39193", "l": "docosanoyl-CoA + NADP(+) => (2E)-docosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74578", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] <=> N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59553", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 => H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254251", "l": "ERBB4s80 binds YAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27651", "l": "GTP + uridine => GDP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013024", "l": "RHOB binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68351", "l": "ATP + GTP <=> diphosphate + pppA(2'-5')pG", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52209", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22985", "l": "carbamoyl phosphate + oxamate => N-carbamoyl-2-oxoglycine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15015", "l": "secologanin + tryptamine => 3alpha(S)-strictosidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47654", "l": "phosphate + ribitol => D-ribitol 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77609", "l": "Binding of APOBEC-1 to form editosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65101", "l": "a 1-acylglycerol + hexadecanoyl-CoA => an hexadecanoyl-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390025", "l": "Phosphorylated WTS autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53531", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417820", "l": "P2Y9 receptor can bind to LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65284", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42303", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40213", "l": "3-oxotetradecanedioyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50095", "l": "a fatty acyl-CoA + taurine <=> an N-fatty acyl-taurine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10664", "l": "NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde", "d": [], "t": []}, {"i": "EC:1.1.1.144", "l": "\"perillyl-alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27454", "l": "iodide + L-tyrosine + NADP(+) => 3-iodo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48099", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11796", "l": "ecdysone + O2 = 3-dehydroecdysone + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.16", "l": "\"ecdysone oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009485", "l": "IL34:CSF1 binds CSF1R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30870", "l": "H2O + indole-3-acetaldehyde + NAD(+) <=> (indol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47317", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54718", "l": "H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43520", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 = 2,5-dicarboxyfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038046", "l": "G protein-coupled enkephalin receptor activity", "d": ["Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49270", "l": "23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102805", "l": "codeine O-demethylase activity", "d": ["Catalysis of the reaction: codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + carbon dioxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18565", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.3.1.161", "l": "\"lovastatin nonaketide synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31727", "l": "FADH2 + O2 + styrene = (2S)-2-phenyloxirane + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.11", "l": "\"styrene monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804762", "l": "TP53 forms homotetramers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21995", "l": "acetyl-CoA + L-lysyl-[histone] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656070", "l": "FGFBPs bind FGFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20357", "l": "3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61878", "l": "1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37605", "l": "1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75193", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-fuconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.139", "l": "\"umbelliferone 6-dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71783", "l": "MDH2 reduces OA to MAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61325", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61965", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37117", "l": "CoA + H(+) + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935972", "l": "TJP1 (ZO-1) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644879", "l": "NPAS4:ARNT2 binds BDNF gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52540", "l": "cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0046332", "l": "SMAD binding", "d": ["Binding to a SMAD signaling protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69216", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) = (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44679", "l": "a triacyl-sn-glycerol + all-trans-retinol <=> a diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72086", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O <=> ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30372", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O => (-)-geosmin + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21395", "l": "2-phenylacetaldehyde + H2O + NAD(+) <=> 2-phenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42452", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate = H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23760", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.12.98.1", "l": "\"coenzyme F420 hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875817", "l": "MET phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029690", "l": "Caspase-6 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69142", "l": "Recruitment of Dna2 endonuclease (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71433", "l": "3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050462", "l": "N-acetylneuraminate synthase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61820", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose = epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162187", "l": "DHB is hydroxylated to DHDB by COQ6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170120", "l": "Translocation of Cdc25B to the cytoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44539", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39744", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76941", "l": "2-methylpropanal + H(+) + NADPH + NH4(+) => 2-methylpropan-1-amine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21846", "l": "CoA + H(+) + N(2)-phenylacetyl-L-glutamine => L-glutamine + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11141", "l": "alpha-D-mannose 1-phosphate => D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66350", "l": "(2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2 => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627089", "l": "CASP9 is phosphorylated at T412 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008270", "l": "Activated TAK1 leaves endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21876", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.199", "l": "\"(S)-usnate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714580", "l": "SLC6A3 binds DRIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592278", "l": "Autocatalytic activation of proMMP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34297", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10560", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O = 2,5-dioxopentanoate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.22", "l": "\"1-pyrroline-4-hydroxy-2-carboxylate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1218833", "l": "Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12717", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.140", "l": "\"inositol-tetrakisphosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.86", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48254", "l": "a ganglioside GD1b + H(+) + UDP => a ganglioside GD2 + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21592", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) = H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.28", "l": "\"opine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656893", "l": "OPN1MW binds 11cRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950398", "l": "CANX dissociates from IL27:EBI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69222", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+) => a (Z)-glucosinolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30411", "l": "benzoyl-CoA + benzyl alcohol = benzyl benzoate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.196", "l": "\"benzyl alcohol O-benzoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034806", "l": "benzo(a)pyrene 11,12-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55028", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine = an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47014", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938231", "l": "RUNX1:CBFB binds CREBBP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354124", "l": "Phosphorylation of pPTK2 by SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65127", "l": "benzoyl-CoA + ethanol <=> benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483087", "l": "PI is exchanged with PC by PITPNB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62340", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-malbrancheamide C + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187382", "l": "Degradation of ubiquitinated SMAD3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21341", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 => 2 vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809764", "l": "SBF1 binds MTMR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15955", "l": "ADP + 2 H(+) + N(4)-phosphoagmatine => agmatine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54989", "l": "4 e(-) + 4 H(+)(in) + O2(in) => 2 H2O(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102939", "l": "3-methoxy-5-hydroxytoluene O-methyltransferase activity", "d": ["Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63451", "l": "(2-aminoethyl)phosphonate + CTP <=> CMP-(2-aminoethyl)phosphonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809521", "l": "BPIF binds bacteria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371591", "l": "Trimerization of cytosolic HSF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247497", "l": "ERBB3 binds neuregulins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56653", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74727", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH = 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193068", "l": "CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957241", "l": "TP73 tetramer translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517674", "l": "p-S158,221-HuR binds mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59684", "l": "D-maltohexaose + O2 = D-maltohexaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0061609", "l": "fructose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873926", "l": "IFNG dimer binds IFNGR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909776", "l": "beta-alanine + pyruvate => 3-oxopropanoate + alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036400", "l": "short neuropeptide F receptor activity", "d": ["Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13488", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine <=> 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77513", "l": "(2S)-2-hydroxy-2-(2-methoxyphenyl)acetonitrile => 2-methoxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56615", "l": "L-cysteinyl-[protein] + NAD(+) <=> H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56817", "l": "a pyrimidine ribonucleoside + H2O => a pyrimidine nucleobase + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004136", "l": "deoxyadenosine kinase activity", "d": ["Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709454", "l": "EPOR binds EPOR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25863", "l": "GTP + H2O <=> 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140860", "l": "(3R)-2'-hydroxyisoflavanone reductase activity", "d": ["Catalysis of the reaction: a (3R,4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31013", "l": "camelliol C => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71303", "l": "RPE dimers isomerise RU5P to XY5P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.95", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38142", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43724", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.128", "l": "\"farnesoate epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16260", "l": "alpha,alpha-trehalose + phosphate <=> alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52520", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613768", "l": "SOX10, POU3F1 and POU3F2 bind EGR2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62798", "l": "aurasperone A + 2 H2O + NADP(+) => H(+) + NADPH + O2 + 2 rubrofusarin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102792", "l": "sinapaldehyde:NAD(P)+ oxidoreductase activity", "d": ["Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O = 2 H+ + trans-sinapate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376419", "l": "Formation of NR-MED1 Coactivator Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683888", "l": "LMCD1 binds GATA6, sequestering it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76513", "l": "5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one => 5-deoxystrigol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59864", "l": "(indol-3-yl)butanoate + ATP + L-glutamine = (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53167", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762246", "l": "ANGPTL4 binds CDH11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67415", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59965", "l": "L-seryl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77602", "l": "2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) <=> 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0043364", "l": "glycyl-radical enzyme activating activity", "d": ["Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247843", "l": "secretion of WNT ligands (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204824", "l": "Interaction of Tie2 and Ang4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018503", "l": "trans-1,2-dihydrodiolphenanthrene dehydrogenase activity", "d": ["Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38754", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51607", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678998", "l": "Endosomal TLRs pass through the Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45758", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine => (6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19306", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22897", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23160", "l": "L-rhamnopyranose = L-rhamnulose", "d": [], "t": []}, {"i": "EC:5.3.1.14", "l": "\"L-rhamnose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31163", "l": "(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690449", "l": "S1PR1 bind S1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42032", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.27", "l": "\"[histone H3]-dimethyl-L-lysine(36) demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73347", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine = beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373738", "l": "Neurofascin interacts with syntenin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1901683", "l": "arsenate ion transmembrane transporter activity", "d": ["Enables the transfer of an arsenate ion from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42437", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] => L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814764", "l": "Plasma membrane resorption (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983427", "l": "Expression of peptide bound class I MHC on cell surface (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804596", "l": "APAF1:CYCS binds APIP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50142", "l": "(14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43761", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48838", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69492", "l": "O2 + octan-1-ol = H2O2 + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58973", "l": "H2O + O2 + vanillin => H(+) + H2O2 + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30063", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine = H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69861", "l": "a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 12S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084910", "l": "Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31082", "l": "3-hydroxyisovaleryl-CoA <=> 3-methyl-(2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40168", "l": "hexadecanoyl-CoA + O2 => (2E)-hexadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38980", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20514", "l": "2-aryl-2-methylmalonate + H(+) => 2-arylpropionate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018628", "l": "terephthalate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14419", "l": "H(+) + N(6)-acetyl-L-lysine + phosphate => acetyl phosphate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001517", "l": "N-acetylglucosamine 6-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24113", "l": "2 glutathione + O2 => glutathione disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002171", "l": "low-affinity IgA receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871265", "l": "YAP1 binds TEAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177937", "l": "Phosphorylation of EGFR by SRC kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0000701", "l": "purine-specific mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site."], "t": []}, {"i": "EC:3.2.2.31", "l": "\"adenine glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018754", "l": "GDIs bind RHOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29315", "l": "alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.94", "l": "\"D-galactose 1-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003837", "l": "beta-ureidopropionase activity", "d": ["Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621048", "l": "TPH1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42552", "l": "uridine(31) in tRNA = pseudouridine(31) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.42", "l": "\"tRNA pseudouridine(31) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65684", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67848", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66062", "l": "H2O + kynurenate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004439", "l": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.170", "l": "\"3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683663", "l": "N-glycan trimming of Spike (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71641", "l": "K(+)(out) + Na(+)(out) => K(+)(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16305", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11111", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35459", "l": "cholesterol + NAD(+) = cholest-5-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68431", "l": "lutein + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37297", "l": "ADP + H(+) + L-alanyl-L-threonine(in) + phosphate => ATP + H2O + L-alanyl-L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41686", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660980", "l": "p-S276-RELA binds RELB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112385", "l": "Addition of nucleotides leads to transcript elongation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54200", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032896", "l": "palmitoyl-CoA 9-desaturase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12086", "l": "D-fructose + H(+) + NADH => D-mannitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59461", "l": "hexadecan-1-ol + NADP(+) => H(+) + hexadecanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69589", "l": "inosine + UMP => IMP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73363", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine = beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54475", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72387", "l": "2 hydrogencarbonate(out) + sulfate(in) = 2 hydrogencarbonate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399939", "l": "Autophosphorylation of PAK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865454", "l": "CBFB binds RUNX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53071", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate <=> 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57472", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937343", "l": "NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392530", "l": "p-S400-Cot phosphorylates NIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59666", "l": "D-cellopentaono-1,5-lactone + H2O2 => D-cellopentaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0008169", "l": "C-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35254", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047391", "l": "alkylglycerophosphoethanolamine phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40346", "l": "3-oxohexadecanedioyl-CoA + CoA <=> acetyl-CoA + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762343", "l": "PREDL:ALB dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58712", "l": "NADH + O2 + rifampicin = H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32218", "l": "(6R)-NADHX <=> (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68267", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59556", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone = H(+) + N,N'-diacetylchitobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71813", "l": "3,3',5-triiodo-L-thyronine(in) => 3,3',5-triiodo-L-thyronine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008882", "l": "[glutamate-ammonia-ligase] adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928641", "l": "PAK binds RAC and bPIX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12696", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine <=> 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.287", "l": "\"D-arabinitol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102250", "l": "linear malto-oligosaccharide phosphorylase activity", "d": ["Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134800", "l": "STING dimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56153", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18758", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => CO2 + cylindrospermopsin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61483", "l": "a sphingoid base + a very long-chain fatty acyl-CoA <=> an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354066", "l": "Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75987", "l": "a dicarboxylate(in) + indoxyl sulfate(out) = a dicarboxylate(out) + indoxyl sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59310", "l": "D-galactonate + H(+) => D-galactono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37485", "l": "1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10925", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532603", "l": "Nephrin mediated activation of N-WASP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33713", "l": "2 H(+) + maleylacetate + sulfite => 4-sulfomuconolactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43700", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38384", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61305", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose => H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48672", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66939", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate <=> avenanthramide C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11802", "l": "AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) => H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57623", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730860", "l": "Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52588", "l": "choloyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63472", "l": "all-trans-hexaprenol + ATP = ADP + all-trans-hexaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.5", "l": "\"galactose-6-sulfurylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009016", "l": "succinyldiaminopimelate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50705", "l": "1-propanol + NAD(+) => H(+) + NADH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9737780", "l": "MTTP binds lomitapide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58868", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}, {"i": "EC:1.14.18.11", "l": "\"plant 4alpha-monomethylsterol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16535", "l": "H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56732", "l": "4,4-dihydroxy-all-trans-beta-carotene = echinenone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20929", "l": "[DsbA protein]-dithiol + a quinone => [DsbA protein]-disulfide + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46590", "l": "calcidiol + H2O + 2 oxidized [adrenodoxin] => calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.n1", "l": "\"peptidoglycan lytic exotransglycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69039", "l": "5beta-androstane-3,17-dione + H(+) + NADPH <=> 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55458", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol => ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66619", "l": "Mg(2+)(in) + 2 Na(+)(out) <=> Mg(2+)(out) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57846", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form) => fraxetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38071", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37402", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635461", "l": "PtpA dephosphorylates GSK3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38234", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976801", "l": "Complement factor I complex formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607747", "l": "TRAF6 binds MALT1 oligomers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47876", "l": "a ganglioside GD1b + H2O = a ganglioside GM1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21870", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.141", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72235", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) = 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37285", "l": "L-alanine + L-histidine => H2O + L-alanyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15022", "l": "(E)-feruloyl-CoA + L-quinate => 4-O-feruloyl-D-quinate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42172", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 = (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21174", "l": "5-dehydro-D-gluconate + H(+) + NADH => L-idonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35607", "l": "acetoin + NADP(+) = diacetyl + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705320", "l": "TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54534", "l": "2-oxoglutarate + L-cysteinylglycine => H2O + N-(4-oxoglutaryl)-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.57", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48709", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004040", "l": "amidase activity", "d": ["Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40308", "l": "A + decanedioyl-CoA => (2E)-decenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018456", "l": "aryl-alcohol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798749", "l": "Exocytosis of specific granule lumen proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65018", "l": "4-hydroxychlorothalonil + chloride + 2 H(+) => chlorothalonil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23916", "l": "H(+) + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose", "d": [], "t": []}, {"i": "EC:4.1.1.35", "l": "\"UDP-glucuronate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57877", "l": "uridine(54) in tRNA => pseudouridine(54) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950716", "l": "IL27RA binds JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56519", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 <=> 2 CO2 + 4 H2O + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75439", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71718", "l": "H(+)(out) + L-leucyl-L-leucine(out) <=> H(+)(in) + L-leucyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40974", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35636", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690494", "l": "RHOB translocates to the endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38461", "l": "2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65576", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate = an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63799", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050405", "l": "[acetyl-CoA carboxylase] kinase activity", "d": ["Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033726", "l": "aldehyde ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183052", "l": "CBL binds to GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65889", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61250", "l": "3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => H2O + L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75243", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76493", "l": "acetate + vanillin => (E)-ferulate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591052", "l": "PROCR binds Protein C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626753", "l": "H2O2 oxidizes Cys residues to form Cys-sulfenic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70320", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209566", "l": "TRAF6 is auto-ubiquitinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37361", "l": "D-glucosamine 6-phosphate(in) + L-histidyl-[protein] => D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12084", "l": "D-mannitol + NAD(+) = D-fructose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.67", "l": "\"mannitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34496", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983424", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72697", "l": "Start codon recognition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662608", "l": "MT2A binds cadmium (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22049", "l": "7,8-dihydroneopterin 3'-triphosphate => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005503", "l": "all-trans retinal binding", "d": ["Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58926", "l": "(-)-maackiain + H2O => (3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47683", "l": "D-galactosamine 6-phosphate + H2O <=> D-tagatopyranose 1-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12322", "l": "1,2-dihydrovomilenine + 2 H(+) + NADPH => 17-O-acetylnorajmaline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34765", "l": "(S,S)-tartrate(in) + succinate(out) => (S,S)-tartrate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13619", "l": "5-(methylsulfanyl)-D-ribose + adenine => H2O + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32661", "l": "(6E)-8-oxogeranial + 2 H(+) + 2 NADPH => (6E)-8-hydroxygeraniol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14546", "l": "H2O + nicotinamide => NH4(+) + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047808", "l": "D(-)-tartrate dehydratase activity", "d": ["Catalysis of the reaction: D-tartrate = H2O + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928625", "l": "PAKs autophosphorylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011748", "l": "IL9R binds JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67818", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15716", "l": "a beta-D-galactoside + acetyl-CoA <=> a 6-acetyl-beta-D-galactoside + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336420", "l": "DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835454", "l": "DNAJC3 binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389841", "l": "MTFMT formylates methionyl-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140680", "l": "histone H3K36me/H3K36me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218906", "l": "RIPK3 phosphorylates MLKL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876789", "l": "CARNMT1 methylates CARN to Anserine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62487", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49499", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55555", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785594", "l": "FANCD2 binds FANCI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41119", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625416", "l": "Anterograde IFT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865182", "l": "OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.796139606449842", "identifiers": [{"i": "GO:0042054", "l": "histone methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69457", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912357", "l": "ITCH ubiquitinates DTX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59293", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O => D-galactose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63600", "l": "H2O + neocasomorphin = L-isoleucine + neocasomorphin-(1-5)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24061", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69127", "l": "Formation of the Flap Intermediate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77067", "l": "H2O + NADP(+) + pentylamine = H(+) + NADPH + NH4(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25539", "l": "ent-copalyl diphosphate <=> diphosphate + ent-sandaracopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032142", "l": "single guanine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73678", "l": "ADP(out) + dAMP(in) + H(+)(out) <=> ADP(in) + dAMP(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58841", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.4", "l": "\"xanthine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804425", "l": "TP53 binds POU4F2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43857", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114354", "l": "SMAC binds XIAP:Caspase-7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63930", "l": "an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43160", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.223", "l": "\"tRNA1(Val) (adenine(37)-N(6))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956676", "l": "YAP1 binds TP73 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54918", "l": "9-cis-retinal + H(+) + NADPH => 9-cis-retinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is not sequence specific\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015532", "l": "alpha-ketoglutarate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43513", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 => 2-carboxy-5-formylfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56434", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50115", "l": "octadecanoyl-CoA + taurine <=> CoA + H(+) + N-octadecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112435", "l": "Formation of Elongin BC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.15", "l": "\"(S)-2-hydroxy-acid oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62541", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain => dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29946", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) <=> 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32855", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22990", "l": "acetyl-CoA + CO2 + NADPH => 3-oxopropanoate + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.50", "l": "\"alpha-N-acetylglucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010307", "l": "acetylglutamate kinase regulator activity", "d": ["Binds to and modulates the activity of acetylglutamate kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9737780", "l": "MTTP binds lomitapide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.1", "l": "\"transketolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37548", "l": "D-glucose 6-phosphate + NAD(+) => 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57338", "l": "3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467811", "l": "Separation of sister chromatids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58250", "l": "ADP-D-ribose + H(+) + L-glutamyl-[protein] => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.126200859969501", "identifiers": [{"i": "GO:0140938", "l": "histone H3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295632", "l": "PPA2A dephosphorylates SPRY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22908", "l": "3',5'-cyclic AMP + H(+) + H2O = 3',5'-cyclic IMP + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.46", "l": "\"cAMP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12100", "l": "1,5-anhydro-D-fructose = H2O + microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50518", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48185", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45472", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13723", "l": "H(+) + testolate => H2O + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426032", "l": "DAG is metabolized by DAGL to 2-AG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102054", "l": "maleylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O = H+ + maleate(2-) + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627107", "l": "XIAP binds CASP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57791", "l": "1,3-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54668", "l": "pre-alpha-onocerin = alpha-onocerin", "d": [], "t": []}, {"i": "EC:5.4.99.66", "l": "\"alpha-onocerin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418553", "l": "cAMP degradation by Phosphodiesterases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55057", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54690", "l": "2-aminoprop-2-enoate + allylsulfenate => alliin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937369", "l": "ATAD2 binds ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30172", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64139", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine <=> (9Z)-octadecenoate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17499", "l": "ononin + UDP => formononetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.98", "l": "\"hepacivirin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693148", "l": "BCKDK phosphorylates BCKDH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73923", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine = griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16008", "l": "galactarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871266", "l": "YAP1 binds TEAD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0044769", "l": "ATPase activity, coupled to transmembrane movement of ions, rotational mechanism", "d": ["Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54279", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182990", "l": "Sprouty sequesters CBL away from active EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49294", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein] => D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983153", "l": "E1 mediated ubiquitin activation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034322", "l": "alcohol O-decanoyltransferase activity", "d": ["Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44897", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47786", "l": "5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805205", "l": "GPR35 binds kynurenic acid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15251", "l": "1-O-galloyl-beta-D-glucose + UDP => 3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67114", "l": "H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14639", "l": "adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate => 3'-phosphoadenylyl sulfate + a thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12147", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose <=> cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54172", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) = 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72601", "l": "N-acetyl-L-aspartyl-L-glutamate(in) => N-acetyl-L-aspartyl-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54658", "l": "(2E)-geraniol => linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52944", "l": "cholate + UDP-alpha-D-glucuronate = choloyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50240", "l": "[hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": [], "t": []}, {"i": "EC:4.2.2.1", "l": "\"hyaluronate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050629", "l": "tetrachloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15675", "l": "acetoacetate + CoA + H(+) => acetoacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682388", "l": "Autophagosome maturation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011941", "l": "Estrogen-responsive BCL2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624953", "l": "ARL13B binds INPP5E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12289", "l": "an alpha-L-fucoside + H2O => an alcohol + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12561", "l": "hydroquinone + UDP-alpha-D-glucose => H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-708349", "l": "Activated NOD2 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029453", "l": "Phosphorylation of VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14909", "l": "L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.19", "l": "\"glucuronate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199839", "l": "AKT can phosphorylate RSK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46582", "l": "25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.366", "l": "\"L-idonate 5-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264865", "l": "Caspase-mediated cleavage of Lamin A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30707", "l": "putrescine + pyruvate = 4-aminobutanal + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.113", "l": "\"putrescine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10432", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O = acetate + CO2 + NH4(+) + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:3.5.1.29", "l": "\"2-(acetamidomethylene)succinate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102907", "l": "sesquisabinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + sesquisabinene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51457", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine => (9Z)-octadecenoate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29504", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + patchoulol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196964", "l": "RFK:Mg2+ phosphorylates RIB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69738", "l": "phenylsuccinate + succinyl-CoA <=> 2-phenylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58702", "l": "FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADPH + rifampicin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21468", "l": "dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.316", "l": "\"tylactone mycaminosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16862", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine => (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24107", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA <=> 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0030551", "l": "cyclic nucleotide binding", "d": ["Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033772", "l": "flavonoid 3',5'-hydroxylase activity", "d": ["Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433845", "l": "chicken RIP1 facilitates IKKs complex activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28813", "l": "2,3-dioxo-L-gulonate(out) + Na(+)(out) => 2,3-dioxo-L-gulonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168046", "l": "Collagen type XII degradation by MMP12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202248", "l": "Phosphorylation of PLC-gamma1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14914", "l": "AMP + thymidine => adenosine + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693061", "l": "STAMBP binds STAM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30322", "l": "H(+) + NADH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33397", "l": "GMP + N(alpha)-acetyl-L-lysine methyl ester => H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664879", "l": "ATM:PEX5 binds ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014293", "l": "RAC2 GDIs block activation of RAC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15883", "l": "ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein] => ATP + L-seryl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62492", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine = AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.63", "l": "\"L-arginine--[L-arginyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865320", "l": "CBFB binds RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836275", "l": "TFAP2A binds TFAP2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33075", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.120", "l": "\"aminodeoxyfutalosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54772", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977301", "l": "Histidine is decarboxylated to histamine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28398", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76882", "l": "3-aminobutan-2-ol + H2O + NAD(+) <=> acetoin + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112430", "l": "Formation of P-TEFb complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61610", "l": "[DsbB protein]-disulfide + a quinol => [DsbB protein]-dithiol + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72914", "l": "proatranorin III + S-adenosyl-L-methionine <=> atranorin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76834", "l": "H2O + hexylamine + NAD(+) <=> H(+) + hexanal + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44008", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) = a 2-methyl fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805122", "l": "AURKB binds TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.923108426128749", "identifiers": [{"i": "GO:0008410", "l": "CoA-transferase activity", "d": ["Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936381", "l": "OTUD5 deubiquitinates TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46961", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982017", "l": "Active G alpha (q) binds RGS proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12178", "l": "H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine => phenylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75410", "l": "2-dehydro-D-glucose <=> cortalcerone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47390", "l": "an aliphatic alcohol + H(+) + tetradecanoate => a tetradecanoate ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166038", "l": "GPI-bound CD14 binds LPS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47065", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033920", "l": "6-phospho-beta-galactosidase activity", "d": ["Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23130", "l": "4-hydroxybutanoyl-CoA + AMP + diphosphate => 4-hydroxybutanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46319", "l": "GDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29372", "l": "dAMP + H2O => 2'-deoxyadenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11517", "l": "H2O + succinyl-CoA => CoA + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205136", "l": "GTP-bound RAC contributes to JNK activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10520", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.241", "l": "\"digalactosyldiacylglycerol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784861", "l": "HSPG binds LPL dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192061", "l": "CYP46A1 24-hydroxylates CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41029", "l": "1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50733", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112727", "l": "Serine phosphorylation of STATs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21952", "l": "5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17082", "l": "(E)-isoeugenol + S-adenosyl-L-methionine => (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12776", "l": "2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381704", "l": "G(s):GTP activates Adenylyl cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52498", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65310", "l": "a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17864", "l": "21-hydroxyprogesterone <=> 20-hydroxy-3-oxopregn-4-en-21-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61082", "l": "(+)-echitovenine + CoA => (+)-minovincinine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68288", "l": "heptanoyl-CoA + L-seryl-[protein] = CoA + O-heptanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009673", "l": "low-affinity phosphate transmembrane transporter activity", "d": ["Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12343", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] <=> H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72103", "l": "Formation of pre-mRNPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33583", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate = 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}, {"i": "EC:2.6.1.98", "l": "\"UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75500", "l": "cholate(out) + n H(+)(out) => cholate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005109", "l": "frizzled binding", "d": ["Binding to a frizzled (fz) receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654167", "l": "Activated FGFR1 binds PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426209", "l": "DAG activation of TRPC channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25899", "l": "H(+) + malonate <=> acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454239", "l": "Phosphorylation of SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15848", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67473", "l": "H2O + succinyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16391", "l": "CO2 + H2O + hydroquinone + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12621", "l": "H(+) + L-aspartate = CO2 + L-alanine", "d": [], "t": []}, {"i": "EC:4.1.1.12", "l": "\"aspartate 4-decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74834", "l": "UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) <=> UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211239", "l": "Association of DFF40 with chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067659", "l": "Assembly of hexameric IL-6 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111930", "l": "Adenylate cyclase produces cAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56285", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) => a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64259", "l": "dodecanoyl-CoA + glycine <=> CoA + H(+) + N-dodecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33810", "l": "(E)-ferulate + H(+) <=> 2-methoxy-4-vinylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033888", "l": "chondro-6-sulfatase activity", "d": ["Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25345", "l": "H2O + urea <=> carbamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098627", "l": "protein arginine phosphatase activity", "d": ["Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53892", "l": "an S-prenyl-L-cysteine + H2O + O2 = a prenal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166542", "l": "beta-NGF dimer binds to TrkA receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26227", "l": "abieta-7,13-dien-18-oate + 2 H(+) + NADH => abieta-7,13-dien-18-al + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58121", "l": "ATP + L-seryl-[protein] => 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43264", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22516", "l": "ATP + taurocyamine = ADP + H(+) + N-phosphotaurocyamine", "d": [], "t": []}, {"i": "EC:2.7.3.4", "l": "\"taurocyamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005585", "l": "MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29967", "l": "2'-deoxyuridine(in) + H(+)(in) = 2'-deoxyuridine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247849", "l": "WLS dissociates from retromer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33867", "l": "(S)-2-ureidoglycine + glyoxylate = glycine + N-carbamoyl-2-oxoglycine", "d": [], "t": []}, {"i": "EC:2.6.1.112", "l": "\"(S)-ureidoglycine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17783", "l": "formate + L-methionine => H2O + N-formyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72095", "l": "Internal Methylation of mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33984", "l": "(+)-copalyl diphosphate => diphosphate + miltiradiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53702", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395320", "l": "Latent TGF-beta-1 binds integrins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103035", "l": "NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity", "d": ["Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654533", "l": "KRAS4B recycles to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14948", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9844955", "l": "CLN3 transports GalCer to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19732", "l": "acetoacetate + H(+) <=> acetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807008", "l": "PTPRJ dephosphorylates MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36070", "l": "Co-precorrin-6B + S-adenosyl-L-methionine <=> Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65170", "l": "A + H2O + preaustinoid A1 => AH2 + O2 + preaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656070", "l": "FGFBPs bind FGFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24445", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43618", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48810", "l": "(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70872", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) => L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68505", "l": "(2Z,6Z)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55331", "l": "9-cis-retinol + hexadecanoyl-CoA <=> 9-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418856", "l": "Activation of Rac1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296309", "l": "HCAR3 binds HCAR3 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44874", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36618", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683648", "l": "Spike trimer glycoside chains are extended (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55162", "l": "coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16841", "l": "precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.130", "l": "\"precorrin-2 C(20)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44649", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17734", "l": "acetylenedicarboxylate + H(+) + H2O => CO2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12672", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869543", "l": "TFPA2A homodimer and NPM1 bind the NOP2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77599", "l": "2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604360", "l": "Initial activation of proMMP2 by MMP14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420206", "l": "Phosphorylation of SRC-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40801", "l": "2-methylpropanoate + CoA + H(+) => 2-methylpropanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682388", "l": "Autophagosome maturation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0004112", "l": "cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159250", "l": "ATF7IP binds SETDB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42313", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] => NADPH + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46225", "l": "(E)-feruloyl-CoA + H2O => (E)-ferulate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75237", "l": "L-fucono-1,4-lactone => L-fucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061759", "l": "alpha-ketoglutarate reductase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor."], "t": []}, {"i": "RHEA:21254", "l": "2-oxoglutarate + AH2 => (S)-2-hydroxyglutarate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209365", "l": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23255", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5227009", "l": "ABCF1 binds EIF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23223", "l": "4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23298", "l": "N-acetyl-D-mannosamine + pyruvate => aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015080", "l": "silver ion transmembrane transporter activity", "d": ["Enables the transfer of silver (Ag) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58578", "l": "H(+) + NADPH + precondylocarpine acetate => dihydroprecondylocarpine acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650858", "l": "Meglitinides bind ABCC8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039552", "l": "RIG-I binding", "d": ["Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010872", "l": "SLIT2 binds Dystroglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37349", "l": "ADP + D-alanyl-(R)-lactate + phosphate => (R)-lactate + ATP + D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190263", "l": "FGFR3b binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202703", "l": "CD47 binds SIRP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935864", "l": "miR-302b binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.71", "l": "\"arylamine glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437936", "l": "p-Y348-SYK phosphorylates VAV family (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57847", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48241", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63606", "l": "[Pyr1]apelin-12 + L-phenylalanine => [Pyr1]apelin-13 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51443", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632668", "l": "SMO translocates to the cilium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004950", "l": "chemokine receptor activity", "d": ["Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55032", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine = an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77355", "l": "2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39703", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH = (13Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47239", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35447", "l": "(1'S)-averantin + NADP(+) = H(+) + NADPH + norsolorinic acid", "d": [], "t": []}, {"i": "EC:1.1.1.349", "l": "\"norsolorinic acid ketoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74885", "l": "GUCYs converts GTP to cGMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11435", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside <=> 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58764", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.268", "l": "\"tRNA(Thr) (cytosine(32)-N(3))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793837", "l": "TBX6 binds the MESP2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975040", "l": "KRAB-ZNF / KAP Interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12439", "l": "(E)-caffeoyl-CoA + putrescine <=> CoA + H(+) + N-caffeoylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70936", "l": "L-lysine(in) => L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24730", "l": "anthranilate + H(+) = aniline + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420980", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043889", "l": "(S)-3-O-geranylgeranylglyceryl phosphate synthase activity", "d": ["Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72273", "l": "formate(in) + oxalate(out) => formate(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607746", "l": "PKC-delta is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002950", "l": "ceramide phosphoethanolamine synthase activity", "d": ["Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10130", "l": "all-trans-neoxanthin => all-trans-violaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404193", "l": "IGF1R phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22875", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75518", "l": "H2O + N-acetyl-L-cysteine <=> acetate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27418", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate => 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034832", "l": "geranial dehydrogenase activity", "d": ["Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159733", "l": "Furin cleaves pro-factor X to factor X (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65234", "l": "3-hydroxydodecanoate + CoA + H(+) => 3-hydroxydodecanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57007", "l": "acetyl-CoA + streptothricin D <=> CoA + H(+) + N(beta)-acetylstreptothricin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730842", "l": "PI3K associates with phosphorylated GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102334", "l": "N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity", "d": ["Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77380", "l": "H(+) + hnu + tetradecanoate => CO2 + tridecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42589", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29033", "l": "L-glutamate(out) + 2 Na(+)(out) => L-glutamate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68674", "l": "16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n3", "l": "\"ISG15--protein ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71359", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39870", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50102", "l": "CoA + H(+) + N-dodecanoyl-taurine => dodecanoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64490", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA => acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46950", "l": "N(7)-methyl-GTP + S-adenosyl-L-homocysteine => GTP + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433599", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691174", "l": "RAC1 binds effectors at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14766", "l": "coelenterazine h + O2 => CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10112", "l": "L-homocysteine + L-serine = H2O + L,L-cystathionine", "d": [], "t": []}, {"i": "EC:4.2.1.22", "l": "\"cystathionine beta-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562564", "l": "Caspase-8 processing within TLR4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047160", "l": "alkylglycerophosphate 2-O-acetyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167511", "l": "HLCS biotinylates ACACB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57638", "l": "holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51540", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.51", "l": "\"(S)-corytuberine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944215", "l": "Association of procollagen type XX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21763", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (3R)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851133", "l": "STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38075", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446211", "l": "Flipping of dolichyl-phosphate-glucose into the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76934", "l": "3-aminobutan-2-ol + H2O + NADP(+) <=> acetoin + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080046", "l": "quercetin 4'-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419334", "l": "Melatonin receptors can bind melatonin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169402", "l": "ISGylation of E2 conjugating enzymes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685605", "l": "SLAMF7 binds SLAMF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73037", "l": "Co(2+)(in) + H(+)(in) => Co(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18676", "l": "ATP + L-seryl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016699", "l": "oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.12.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58908", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH = C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73868", "l": "serotonin(out) => serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33790", "l": "3'-ketolactose + H2O <=> 3-keto-beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984775", "l": "Kinesin-9 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66291", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050274", "l": "salicyl-alcohol beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H+ + salicin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464810", "l": "atRAL(membrane) diffuses to atRAL(cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64184", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine = (9Z)-octadecenoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69049", "l": "H2O + hexano-6-lactone => 6-hydroxyhexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35114", "l": "2-dehydro-L-idonate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690702", "l": "LYN phosphorylates CD22 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49401", "l": "H2O + validoxylamine A 7'-phosphate => phosphate + validoxylamine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2245218", "l": "CDK1 phosphorylates PHF8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49552", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451311", "l": "Activation of Ca-permeable Kainate receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804762", "l": "TP53 forms homotetramers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16693", "l": "alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": [], "t": []}, {"i": "EC:5.5.1.10", "l": "\"alpha-pinene-oxide decyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35609", "l": "diacetyl + H(+) + NADPH => acetoin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638137", "l": "EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794523", "l": "SLC22A1 transports Cipro into renal cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67211", "l": "H2O + melatonin <=> 5-methoxytryptamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51498", "l": "a sphingoid 1-phosphate + ADP + H(+) => a sphingoid base + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213246", "l": "Disassociation of CLIP from MHC II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33948", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine => 2'-N-acetylparomamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74211", "l": "H2O + L-threonyl-tRNA(Lys) = L-threonine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804099", "l": "HMGB1 binds LTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34921", "l": "thiamine(out) => thiamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36569", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH => GDP-beta-L-colitose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76935", "l": "2-methylpropan-1-amine + H2O + NAD(+) = 2-methylpropanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825615", "l": "Expression of RIPPLY2 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.62", "l": "\"17beta-estradiol 17-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27500", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine <=> 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56366", "l": "carminomycin + 2 H2O + NADP(+) => 13-dihydrocarminomycin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23552", "l": "2-methylpropane-1,2-diol + NAD(+) = 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.400", "l": "\"2-methyl-1,2-propanediol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11384", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.99", "l": "\"(S)-2-hydroxy-fatty-acid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31643", "l": "mycinamicin VI + S-adenosyl-L-methionine = H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.238", "l": "\"mycinamicin VI 2''-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27357", "l": "iodide + S-adenosyl-L-methionine = iodomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25721", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-trihomomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34063", "l": "2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.284", "l": "\"2-deoxystreptamine glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35633", "l": "cyanidin 3-O-beta-D-galactoside + H(+) + UDP => cyanidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25340", "l": "isocyanate + NH4(+) => H(+) + urea", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59581", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29704", "l": "L-valine(in) => L-valine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18471", "l": "an N(2)-acyl-L-glutamine + CoA + H(+) => an acyl-CoA + L-glutamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21518", "l": "piperitenone => isopiperitenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22467", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8949580", "l": "F1Fo ATP synthase dimerizes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59226", "l": "diphosphate + hydropyrene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25991", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15909", "l": "2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": [], "t": []}, {"i": "EC:1.14.11.17", "l": "\"taurine dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429732", "l": "Multiphospho-CERT1-2 binds PPM1L, VAPA/B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20961", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44064", "l": "hexadecanoyl-CoA + octan-1-ol = CoA + octyl hexadecanoyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63407", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 <=> 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483087", "l": "PI is exchanged with PC by PITPNB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11423", "l": "NADPH + O2 + senecionine <=> H2O + NADP(+) + senecionine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698174", "l": "FLT3 mutants recruit PIK3CA through PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5323526", "l": "FRAT proteins bind GSK3beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801087", "l": "TP53 binds the RABGGTA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202111", "l": "AKT1 phosphorylates eNOS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030158", "l": "protein xylosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046180", "l": "KSPG is secreted from the cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32866", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46922", "l": "CO2 + styrene => (E)-cinnamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41198", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53744", "l": "glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61915", "l": "ATP + H2O + voriconazole(in) <=> ADP + H(+) + phosphate + voriconazole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005049", "l": "nuclear export signal receptor activity", "d": ["Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53226", "l": "3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950362", "l": "EBI3:CANX binds IL12A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174235", "l": "Association of Emi1 with Cdc20 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.17", "l": "\"[phosphorylase] phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30745", "l": "D-ribose + H(+) + nicotinamide => beta-nicotinamide D-riboside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015265", "l": "urea channel activity", "d": ["Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61827", "l": "pregnenolone + UDP-alpha-D-glucose <=> H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14095", "l": "indole-3-pyruvate + L-glutamate => 2-oxoglutarate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29801", "l": "ADP + D-allose(in) + H(+) + phosphate => ATP + D-allose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10184", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.24", "l": "\"3-oxoadipate enol-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12360", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine = 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.93", "l": "\"13-hydroxylupanine O-tigloyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64679", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol <=> butyl 3-(methylsulfanyl)propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54283", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66800", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13757", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-desulfoglucotropeolin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167468", "l": "Abortive HIV-1 Initiation After Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60736", "l": "(2E,6E)-farnesal + H2O + NADP(+) = (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140221", "l": "Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928624", "l": "EPHBs bind EFNBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874083", "l": "p-Y397-PTK2 binds SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32255", "l": "meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.35", "l": "\"pyridoxal kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480301", "l": "Expression of EPAS1 (HIF2A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.156270827921489", "identifiers": [{"i": "GO:0016763", "l": "pentosyltransferase activity", "d": ["Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35256", "l": "ATP + H2O + lipid A-core(in) => ADP + H(+) + lipid A-core(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419277", "l": "GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77594", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol <=> 1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3244643", "l": "STING binds cyclic GMP-AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726875", "l": "HCNs:cAMP bind SNIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156678", "l": "Activation of Cdc25C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604722", "l": "Activation of proMMP9 by proteases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35296", "l": "adenylyl-molybdopterin + H(+) + tungstate => AMP + H2O + W-molybdopterin cofactor", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33722", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13700", "l": "ATP + D-ribose <=> ADP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24163", "l": "D-galactose + O2 <=> D-galacto-hexodialdose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65250", "l": "6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O => AH2 + 5 H(+) + 5 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75017", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65912", "l": "3-hydroxy-L-kynurenine + pyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031419", "l": "cobalamin binding", "d": ["Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55870", "l": "H2O2 + pyruvate => (S)-lactate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67640", "l": "ATP + dZMP = ADP + dZDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654514", "l": "KAL1 binds FGFR1c (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73536", "l": "CDP(out) + UTP(in) => CDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50170", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215406", "l": "PRMT5 binds WDR77 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806610", "l": "Keratin filament formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979071", "l": "KDM6B binds iron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687107", "l": "MAPK4,6 translocate to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31573", "l": "CO2 + H2O + NADP(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796617", "l": "MIB2 binds CFLAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769347", "l": "Activated glucocorticoid receptor binds NPAS4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419428", "l": "S1PR2-5 bind S1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033204", "l": "ribonuclease P RNA binding", "d": ["Binding to RNA subunit of ribonuclease P."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102267", "l": "tRNA-dihydrouridine20b synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60130", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43478", "l": "10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69415", "l": "2 glutathione + tert-butyl hydroperoxide <=> glutathione disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15070", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a => chlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43060", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = beta-D-glucose 1-phosphate + glycerol", "d": [], "t": []}, {"i": "EC:2.4.1.332", "l": "\"1,2-alpha-glucosylglycerol phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29678", "l": "glycerol(in) <=> glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418553", "l": "cAMP degradation by Phosphodiesterases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60396", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634391", "l": "SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12093", "l": "(S)-acetoin => (R)-acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444202", "l": "Receptor FFAR1 binds free fatty acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61352", "l": "ATP + H2O + riboflavin(in) = ADP + H(+) + phosphate + riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19836", "l": "(6R)-10-formyltetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60025", "l": "(R,R)-chrysanthemyl diphosphate + H2O => (R,R)-chrysanthemol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004790", "l": "thioether S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62637", "l": "a hydroperoxide + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] => an alcohol + H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57775", "l": "3-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10451", "l": "2-oxoglutarate + a flavanone + O2 <=> a flavone + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373746", "l": "SEMA4D interacts with CD45 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68550", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol => O2 + psoralen + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647680", "l": "CASP1 cleaves GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905576", "l": "ganglioside GT1b binding", "d": ["Binding to ganglioside GT1b."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45084", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.130", "l": "\"laurate 7-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46851", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009675", "l": "high-affinity sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781899", "l": "USP13 binds SIAH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.33", "l": "\"N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036077", "l": "Defective HYAL1 does not hydrolyse (HA)50 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55807", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24133", "l": "UDP-alpha-D-galactose => UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30716", "l": "(2E)-geraniol => (S)-linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9626928", "l": "CREBBP binds FOXO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034056", "l": "estrogen response element binding", "d": ["Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607751", "l": "TRAF6 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69640", "l": "H2O + phlorizin => beta-D-glucose + phloretin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682009", "l": "ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37366", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417890", "l": "P2Y5 receptor can bind to LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658435", "l": "RAS GAPs bind RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174070", "l": "Association of Cdh1 with the APC/C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60886", "l": "(N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36214", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483212", "l": "PS is decarboxylated to PE by PISD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705926", "l": "AR binds AR agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43356", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000249", "l": "C-22 sterol desaturase activity", "d": ["Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249378", "l": "STING recruits TBK1 and STAT6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49718", "l": "3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+) => 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18704", "l": "arsenite + H2O + 2 oxidized [azurin] <=> arsenate + 3 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12345", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) => H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.166", "l": "\"4-nitrocatechol 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44194", "l": "2-methylhexadecanoyl-CoA + AMP + diphosphate => 2-methylhexadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875661", "l": "GGA3 associates with activated MET receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60768", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 = 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694551", "l": "3CLp cleaves nsp6-11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60718", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADPH => (1R,3R)-chrysanthemal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49170", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68076", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37783", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35034", "l": "L-serine(in) <=> L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59142", "l": "AMP + diphosphate + H(+) + staphyloferrin A => ATP + citrate + N(5)-[(S)-citryl]-D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42483", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73816", "l": "O2 + piceatannol => 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0010485", "l": "histone H4 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619376", "l": "CAMK1 binds calmodulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34233", "l": "4-nitro-6-oxohepta-2,4-dienedioate + H(+) => 5-nitrosalicylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43376", "l": "5'-deoxyinosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60854", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696547", "l": "STAMBPL1 is a deubiquitinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58970", "l": "1-naphthoate + H(+) + H2O2 => 1-naphthaldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443831", "l": "14-3-3-zeta binds Raf1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849428", "l": "PTPN1 binds PTK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34000", "l": "zymosterol => 5alpha-cholesta-7,24-dien-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58969", "l": "1-naphthaldehyde + H2O + O2 => 1-naphthoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45981", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69484", "l": "dodecan-1-ol + O2 = dodecanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45024", "l": "cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50283", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41231", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43111", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55440", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0023024", "l": "MHC class I protein complex binding", "d": ["Binding to a class I major histocompatibility complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433451", "l": "JAK2 binds to p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48523", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995330", "l": "COX10 transforms heme to heme O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32687", "l": "(2E)-geranyl diphosphate = diphosphate + tricyclene", "d": [], "t": []}, {"i": "EC:4.2.3.105", "l": "\"tricyclene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58417", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65374", "l": "a globoside MSGG + CMP + H(+) => a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73132", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine => 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10051", "l": "methanethiol + O-acetyl-L-homoserine <=> acetate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68250", "l": "L-tyrosine(out) + Na(+)(out) => L-tyrosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322422", "l": "Beta-catenin recruits SMARCA4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63634", "l": "a long-chain fatty acyl-[ACP] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52315", "l": "NAD(+) + thromboxane B2 <=> 11-dehydro-thromboxane B2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662618", "l": "MT1G binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189488", "l": "UROS transforms HMB to URO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69349", "l": "S-1-propenyl-L-cysteine sulfoxide => (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34049", "l": "6'''-deamino-6'''-oxoneomycin C + H2O2 => 6'''-deamino-6'''-hydroxyneomycin C + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53437", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72182", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) <=> 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76872", "l": "(S)-1-phenylethylamine + H2O + NAD(+) => acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30724", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate => AH2 + 2 ATP + H2O + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047398", "l": "dolichylphosphate-mannose phosphodiesterase activity", "d": ["Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810158", "l": "HOXB3 chromatin is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30351", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate = 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.130", "l": "\"pyrrole-2-carboxylate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004836", "l": "tyramine-beta hydroxylase activity", "d": ["Catalysis of the hydroxylation of tyramine to form octopamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44050", "l": "8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731708", "l": "nsp10:nsp14 binds to ExoN inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77317", "l": "5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine => glyoxylate + N(omega),N('omega)-dimethyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956676", "l": "YAP1 binds TP73 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428609", "l": "Type I Na+-coupled phosphate co-transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15893", "l": "Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013159", "l": "CDC42 GEFs activate CDC42 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051777", "l": "ent-kaurenoate oxidase activity", "d": ["Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10011", "l": "[protein]-dithiol + a hydroperoxide <=> [protein]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38347", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.103", "l": "\"(S)-3,5-dihydroxyphenylglycine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030544", "l": "Hsp70 protein binding", "d": ["Binding to a Hsp70 protein, heat shock proteins around 70kDa in size."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41499", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71529", "l": "thymine(in) => thymine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43652", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029521", "l": "NR1H2,3 binds the ABCG5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49034", "l": "4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15147", "l": "alpha,alpha-trehalose => D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0008237", "l": "metallopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19309", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.70", "l": "\"mannosyl-3-phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627056", "l": "Procaspase 9 forms dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67043", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) <=> asnovolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37243", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65288", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34032", "l": "2'-N-acetylparomamine + H2O => acetate + paromamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10988", "l": "H2O + nitrous oxide = 2 e(-) + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374723", "l": "Nociceptin receptor binds to nociceptin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047127", "l": "thiomorpholine-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75148", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-cyatha-3,12-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008437", "l": "thyrotropin-releasing hormone activity", "d": ["The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20254", "l": "(2R,3S)-2,3-dimethylmalate => dimethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65226", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18956", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33992", "l": "(2E,6E)-farnesyl diphosphate => alpha-copaene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26202", "l": "ammeline + H(+) + H2O => ammelide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23783", "l": "H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938356", "l": "RMB14 binds RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654163", "l": "Activated FGFR4 binds PLCG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38041", "l": "a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50504", "l": "acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54816", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:2.3.2.13", "l": "\"protein-glutamine gamma-glutamyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65645", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799441", "l": "TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730862", "l": "Autophosphorylation of LYN kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399939", "l": "Autophosphorylation of PAK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52236", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71459", "l": "H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35616", "l": "hydroxyacetone + NAD(+) => H(+) + methylglyoxal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9822539", "l": "VWF multimer binds to collagen type I (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77522", "l": "furfural + hydrogen cyanide <=> (2R)-2-(furan-2-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641206", "l": "RSPOs bind LGRs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157100", "l": "NOTCH3 binds JAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52329", "l": "L-arginine + O2 + reduced [flavodoxin] => H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12179", "l": "phenylethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75125", "l": "acetate + 2 H(+) + phosphate => (1R)-(1-hydroxyethyl)phosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670155", "l": "CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110319", "l": "Elongation by POLH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22438", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62388", "l": "[(1->2)-beta-D-glucosyl](n) + H2O = [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": [], "t": []}, {"i": "EC:3.2.1.214", "l": "\"exo beta-1,2-glucooligosaccharide sophorohydrolase (non-reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69885", "l": "L-ascorbate(in) + 2 Na(+)(in) => L-ascorbate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20872", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.314", "l": "\"ginsenoside Rd glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27477", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + neopinone + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.31", "l": "\"thebaine 6-O-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35975", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 = A + CO2 + H2O + succinate + verruculogen", "d": [], "t": []}, {"i": "EC:1.14.11.38", "l": "\"verruculogen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45329", "l": "7,8-dihydroneopterin => 7,8-dihydromonapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17989", "l": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20030", "l": "10-deoxysarpagine + NADP(+) => H(+) + NADPH + vellosimine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68848", "l": "(2Z,6E)-farnesyl diphosphate = diphosphate + gamma-cadinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75922", "l": "H2O + NADP(+) + serinol <=> dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56845", "l": "nocamycin E + S-adenosyl-L-methionine => nocamycin I + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236948", "l": "Antigen processing by cathepsin S in endosoytic vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53416", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine = 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001156", "l": "TFIIIC-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11474", "l": "an L-alpha-amino acid + formaldehyde + H2O2 => an N-methyl-L-amino acid + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023983", "l": "18(R)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102538", "l": "UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392530", "l": "p-S400-Cot phosphorylates NIK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38991", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66221", "l": "asc-omegaC7-CoA + O2 => asc-omegaDeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141093", "l": "5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity", "d": ["Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H+ + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46238", "l": "a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19404", "l": "methanol + NAD(+) <=> formaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50984", "l": "prostaglandin E2(out) = prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36216", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016309", "l": "1-phosphatidylinositol-5-phosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10742", "l": "a ketone + H(+) + NADH => a secondary alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141096", "l": "ligand-activated transcription repressor activity", "d": ["A DNA-binding transcription repressor activity regulated by binding to a ligand and that inhibits the transcription of specific genes and gene sets."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726949", "l": "PTGIR binds PTGIR agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951500", "l": "Dissociation of CANX from nonameric complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40380", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63485", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15446", "l": "H(+) + H2O + O-carbamoyl-L-serine => CO2 + 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051009", "l": "O-acetylhomoserine sulfhydrylase activity", "d": ["Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58936", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH = all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783670", "l": "CRLF1 binds CLCF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201669", "l": "Beta-catenin translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65964", "l": "ATP + H2O + taurocholate(out) = ADP + H(+) + phosphate + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73471", "l": "D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51043", "l": "indole-3-pyruvate imine dimer <=> chromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871373", "l": "BMX phosphorylates RUFY1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48029", "l": "H2O + triacetin => acetate + diacetylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11781", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373748", "l": "SEMA4D interacts with CD72 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38250", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol <=> 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140955", "l": "histone H3K36 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38861", "l": "bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034895", "l": "pyridine-3,4-diol dioxygenase activity", "d": ["Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52990", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine => [deoxyhypusine synthase]-L-lysine + dehydrospermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53809", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27926", "l": "UMP(in) = UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008684", "l": "TBK1 phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61030", "l": "S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein] => itaconate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69326", "l": "4-methylsulfanylbutyl isothionate + H(+) + sulfate => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55921", "l": "[cis-1,4-isoprene](n) + O2 => (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070530", "l": "K63-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63225", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71484", "l": "H2O + Met-enkephalin => L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38743", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661432", "l": "BIL binds ALB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002466", "l": "Formation of allysine by LOX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30534", "l": "biotinate sulfoxide + H(+) + NADH <=> biotin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901024", "l": "MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62702", "l": "acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol => H2O + naphtopyrone YWA1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018754", "l": "GDIs bind RHOH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668545", "l": "NIK autophosphorylates on T559 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1006169", "l": "Factor H binds host cell surface markers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45123", "l": "(4R)-ipsdienol + NAD(+) <=> H(+) + ipsdienone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76591", "l": "N,N-dimethylglycine(out) + Na(+)(out) = N,N-dimethylglycine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199935", "l": "MSK1 activates CREB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60036", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate = 3-hydroxy-3-methylhexanoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15417", "l": "L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73961", "l": "4-ethyl-2-methoxyphenol + NAD(+) => 2-methoxy-4-vinylphenol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75109", "l": "32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31197", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3S)-hydroxyoctanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140440", "l": "protein-cysteine S-oleoyltransferase activity", "d": ["Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59744", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72714", "l": "cathenamine + H(+) <=> 4,21-dehydrogeissoschizine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047463", "l": "2-aminohexano-6-lactam racemase activity", "d": ["Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58143", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) <=> AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72224", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) => 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52945", "l": "cholate + UDP-alpha-D-glucuronate => choloyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13637", "l": "H(+) + methane + NADH + O2 = H2O + methanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52167", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097005", "l": "adipokinetic hormone receptor binding", "d": ["Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69842", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52801", "l": "acetoacetyl-CoA + ATP + L-isoleucine => AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11076", "l": "anthranilate + 3 H(+) + NADH + O2 = catechol + CO2 + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37032", "l": "D-ribonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45744", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) = 7,8-dihydropteroate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187506", "l": "Translocation of p27 to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73744", "l": "2 H(+)(out) + serotonin(in) => 2 H(+)(in) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30858", "l": "dammarenediol-II <=> (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016632", "l": "oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome."], "t": []}, {"i": "EC:1.3.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61505", "l": "pelargonidin + UDP-alpha-D-glucose => pelargonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854209", "l": "TBC1D10A binds JFC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67895", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine <=> 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60042", "l": "(2E)-3-methylhex-2-enoate + L-glutamine => H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004875", "l": "complement receptor activity", "d": ["Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46614", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.-", "l": "\"With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38191", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169719", "l": "Secreted CD14 binds LPS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.1.-", "l": "\"With NADH or NADPH as donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61396", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12218", "l": "9H-fluoren-9-one + H(+) + NADH => 9H-fluoren-9-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57013", "l": "a menaquinone + H2O + sulfite => a menaquinol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204824", "l": "Interaction of Tie2 and Ang4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51011", "l": "2 Fe(III)-[cytochrome cL] + methanol <=> 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17651", "l": "acetate + malonyl-[ACP] => acetyl-[ACP] + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428273", "l": "SPHK1 phosphorylates sphingoid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392513", "l": "Rap1 signal termination by Rap1GAPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007447", "l": "E2F6 forms the PRC1L4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48443", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655269", "l": "Activated FGFR1 mutants bind FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112435", "l": "Formation of Elongin BC complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62477", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24999", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205289", "l": "Autophosphorylation of KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74718", "l": "Internalisation of the insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70711", "l": "D-alanine(in) = D-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70579", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71796", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) => (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11431", "l": "beta-D-glucose + O2 <=> D-glucono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164840", "l": "ADP and Pi bind to ATPase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44600", "l": "a fatty acid + ATP + H(+) = a fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42083", "l": "all-trans-retinal + H2O + NAD(+) <=> all-trans-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35134", "l": "H(+)(out) + L-alanyl-L-glutamate(out) <=> H(+)(in) + L-alanyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40853", "l": "(2E)-pentadecenoyl-CoA + FADH2 => FAD + H(+) + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64207", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72188", "l": "H(+)(out) + sucrose(out) => H(+)(in) + sucrose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52647", "l": "D-xylono-1,4-lactone 5-phosphate + H2O <=> 5-phospho-D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36334", "l": "ATP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36698", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid <=> desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696816", "l": "tRNA ligase complex ligates tRNA exons (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55621", "l": "a carotenoid psi-end group => a carotenoid beta-end derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373745", "l": "SDK1 homophillic interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120019", "l": "phosphatidylcholine transfer activity", "d": ["Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.105", "l": "\"rhomboid protease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955844", "l": "RBKS phosphorylates ribose to R5P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615348", "l": "AGT(34-41) binds to AGTR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46662", "l": "5beta-pregnan-3,20-dione + NADP(+) => H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72910", "l": "D-mannose(out) + Na(+)(out) <=> D-mannose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047675", "l": "arabinonate dehydratase activity", "d": ["Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36202", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23877", "l": "protoaphin aglucone => H2O + xanthoaphin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.15", "l": "\"cathepsin L\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57783", "l": "2-chloro-4-nitrotoluene + NADH + O2 <=> 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25123", "l": "H(+) + H2O + L-1-piperideine-6-carboxylate => (S)-2-amino-6-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250463", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19964", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate <=> a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61791", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan <=> AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14380", "l": "(3R)-3-hydroxy-L-aspartate <=> glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008177", "l": "RUNX2 binds HEY1,HEY2,HES1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72872", "l": "anthocyanin A3 + malonyl-CoA => anthocyanin A5 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17725", "l": "(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.79", "l": "\"2-methylcitrate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25079", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) => 4-methyl-2-oxopentanoate + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655320", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72217", "l": "2 hydrogencarbonate(in) + Na(+)(in) => 2 hydrogencarbonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74670", "l": "(6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate <=> (2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183052", "l": "CBL binds to GRB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66015", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76325", "l": "L-aspartate(out) + L-valine(in) => L-aspartate(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858435", "l": "TSPAN7 binds PICK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50989", "l": "prostaglandin F2alpha(out) => prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21595", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38925", "l": "a ubiquinol + Na(+)(out) + NAD(+) => a ubiquinone + H(+) + Na(+)(in) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008662", "l": "1-phosphofructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647980", "l": "mature RAS proteins translocate to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:1990190", "l": "peptide-glutamate-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69852", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) => a uridine in mRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35016", "l": "riboflavin(in) => riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.120", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15029", "l": "D-mannitol + NAD(+) = D-mannose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.255", "l": "\"mannitol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354077", "l": "Integrin alphaIIb beta3 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23501", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) => 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73164", "l": "FAD(out) + NAD(+)(in) => FAD(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391168", "l": "SIRP gamma binds CD47 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47770", "l": "2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112755", "l": "SOCS3 binds IL6ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71104", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) => L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003853", "l": "2-methylbutanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20672", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033404", "l": "UUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUG codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646347", "l": "PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46791", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71836", "l": "estrone 3-sulfate(out) => estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57711", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035925", "l": "mRNA 3'-UTR AU-rich region binding", "d": ["Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70549", "l": "3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16275", "l": "a sphingomyelin + CMP + H(+) => an N-acylsphing-4-enine + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709179", "l": "DPP4 binds DPP4 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66536", "l": "A + cholest-4,6-dien-3-one + H2O = 25-hydroxycholest-4,6-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40498", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 <=> N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980048", "l": "DLL1 binds NOTCH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810030", "l": "MTMR2 binds MTMR10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51963", "l": "(Z)-2-methylpropanal oxime <=> 2-methylpropanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63714", "l": "a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49624", "l": "ATP + erythritol = ADP + D-erythritol 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.215", "l": "\"erythritol kinase (D-erythritol 1-phosphate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36053", "l": "2 beta-L-arabinofuranose => beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62690", "l": "2 H2O + 2 ustilaginoidin A => 4 norrubrofusarin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389352", "l": "Translocation of Vav1 to CD28 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58562", "l": "15alpha-stemmadenine intermediate I + NADPH => 15alpha-stemmadenine intermediate II + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444527", "l": "FPR is a receptor for formyl peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31556", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA => (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106162", "l": "mRNA N-acetyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H+ + phosphate."], "t": []}, {"i": "RHEA:58480", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24975", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044589", "l": "pectin binding", "d": ["Binding to pectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854981", "l": "SHC1 in the RET complex is phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031783", "l": "type 5 melanocortin receptor binding", "d": ["Binding to a type 5 melanocortin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912503", "l": "Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42856", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56006", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66599", "l": "O2 + 2 tyramine <=> 2 dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30614", "l": "A + all-trans-zeta-carotene <=> AH2 + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008692", "l": "IL37(?-218) binds SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28668", "l": "H(+) + hydroxyacetone + NADH => (S)-propane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43995", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 <=> 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23240", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10222", "l": "AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr) => ATP + L-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76199", "l": "oxalate(in) = oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700120", "l": "PTN and MDK bind to PTPRZ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16544", "l": "9-cis-violaxanthin + O2 <=> (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3828025", "l": "DCN (decorin) degradation by MMP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36774", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24205", "l": "acetyl phosphate + H(+) + sulfite => phosphate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679000", "l": "Ivacaftor binds CFTR G551D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660666", "l": "CBP and p300 binds NF-kB complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11480", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.23", "l": "\"3-hydroxybenzoate 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32723", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29906", "l": "ATP + D-ribose(out) + H2O <=> ADP + D-ribose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76670", "l": "furfural + H2O + NAD(+) <=> 2-furoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43429", "l": "1,2-didecanoyl-sn-glycerol + ATP => 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75029", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol => 1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373745", "l": "SDK1 homophillic interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985594", "l": "MYO9B inactivates RHOA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63909", "l": "ATP + H2O + pravastatin(in) => ADP + H(+) + phosphate + pravastatin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047276", "l": "N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8979071", "l": "KDM6B binds iron (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73247", "l": "ladanein + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.9", "l": "\"selenate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37229", "l": "(E)-1,3-pentadiene + CO2 => (E,E)-sorbate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696547", "l": "STAMBPL1 is a deubiquitinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701064", "l": "TRPV1 binds TRPV1 agonists (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17931", "l": "ADP + an N-acylsphing-4-enine 1-phosphate + H(+) => an N-acylsphing-4-enine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11870", "l": "D-ribulose + H(+) + NADPH => D-arabinitol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53283", "l": "D-threose <=> D-erythrulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28773", "l": "(9Z)-hexadecenoyl-CoA => (2E)-hexadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102690", "l": "isopentenyladenine UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43323", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin <=> a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22475", "l": "(R)-pantetheine + ATP <=> (R)-4'-phosphopantetheine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.3", "l": "\"DNA 5'-3' helicase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52154", "l": "(Z)-indolylmethyl desulfoglucosinolate + UDP => (Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202375", "l": "Recruitment of ITK to SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53797", "l": "deoxycholoyl-CoA + ursodeoxycholate => deoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41031", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17417", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.59", "l": "\"N-acetylglucosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51420", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936380", "l": "Interaction of PIN1 with p-IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031803", "l": "type 6 metabotropic glutamate receptor binding", "d": ["Binding to a type 6 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197963", "l": "DHFR2 reduces FOLA to DHF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705584", "l": "HMGCR dimer binds statins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015413", "l": "ABC-type nickel transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40149", "l": "CoA + eicosanoate + H(+) => eicosanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76841", "l": "H(+) + NADH + NH4(+) + propanal => H2O + NAD(+) + propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140841", "l": "RNA polymerase II C-terminal domain O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692749", "l": "CDC14A,B bind MAPK6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25524", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = 9alpha-copalyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.14", "l": "\"syn-copalyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948757", "l": "AKT phosphorylates MKRN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74718", "l": "Internalisation of the insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435244", "l": "PECAM1 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199112", "l": "CRTAM binds to NECL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54326", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682709", "l": "LGI4 binds ADAM22,23,11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29118", "l": "H(+) + menaquinone-8 + NADPH <=> menaquinol-8 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37658", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29224", "l": "menaquinone-8 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814096", "l": "ARL1:GTP binds SCOC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55354", "l": "13-cis-retinol => all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44811", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733969", "l": "Bile salts dissociate from FABP6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12422", "l": "ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => ATP + D-tagatofuranose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63504", "l": "daunorubicin + H(+) + NADPH = 13-dihydrodaunorubicin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12026", "l": "D-glucose + O-sinapoylcholine => 1-O-(trans-sinapoyl)-beta-D-glucose + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670014", "l": "Factor VIIIa dissociates  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848818", "l": "PTK6 phosphorylates CBL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19835", "l": "(6S)-5,6,7,8-tetrahydrofolate + formate + H(+) => (6R)-10-formyltetrahydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198314", "l": "DAG stimulates protein kinase C-delta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621042", "l": "TF gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22209", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015230", "l": "FAD transmembrane transporter activity", "d": ["Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212380", "l": "Formation of TRAP coactivator complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3076905", "l": "Extracellular BTD hydrolyses BCTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48202", "l": "reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA => H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53769", "l": "allocholate + allodeoxycholoyl-CoA => allocholoyl-CoA + allodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55546", "l": "H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77177", "l": "5-hydroxymethyl-dUMP + NH4(+) => 5-hydroxymethyl-dCMP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61831", "l": "stigmasterol + UDP-alpha-D-glucose <=> H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611277", "l": "P2RY12 binds P2RY12 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76840", "l": "H2O + NAD(+) + propylamine => H(+) + NADH + NH4(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57031", "l": "FADH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31665", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47402", "l": "(7Z)-hexadecenoyl-CoA + acetyl-CoA => 3-oxo-(9Z-octadecenoyl)-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.176141984063477", "identifiers": [{"i": "GO:0019239", "l": "deaminase activity", "d": ["Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40968", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41749", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58470", "l": "2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50064", "l": "ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0098638", "l": "laminin binding involved in cell-matrix adhesion", "d": ["Any laminin protein binding that occurs as part of cell-matrix adhesion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21836", "l": "D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.5", "l": "\"arabinonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32067", "l": "8-oxoguanine + H(+) + H2O = NH4(+) + urate", "d": [], "t": []}, {"i": "EC:3.5.4.32", "l": "\"8-oxoguanine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.774074961591239", "identifiers": [{"i": "GO:0030594", "l": "neurotransmitter receptor activity", "d": ["Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373738", "l": "Neurofascin interacts with syntenin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47723", "l": "H(+) + H2O + isoguanine <=> NH4(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63707", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32224", "l": "(6S)-NADHX + ADP => AMP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39117", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18553", "l": "(2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.7", "l": "\"meso-tartrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102156", "l": "2,5-DHBA UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose = 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48466", "l": "a ganglioside GA1 + N-acetylneuraminate => a ganglioside GM1b + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353023", "l": "3-phosphoglycerate + ATP <=> 1,3-bisphosphoglycerate + ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77385", "l": "CO2 + heptane => H(+) + hnu + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39930", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60629", "l": "AH2 + gluconapin + O2 => A + H2O + progoitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59606", "l": "H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+) => H2O + O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19980", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester <=> adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749647", "l": "CES2 hydrolyzes ASA- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39568", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69486", "l": "dodecanal + H2O2 => dodecan-1-ol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682769", "l": "LGI2 binds ADAM22,23 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170159", "l": "Translocation of Cdc25 to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75192", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14113", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.32", "l": "\"polynucleotide 3'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41010", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin <=> 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20544", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937369", "l": "ATAD2 binds ESR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41333", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018615", "l": "2-indanone monooxygenase activity", "d": ["Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004174", "l": "electron-transferring-flavoprotein dehydrogenase activity", "d": ["Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112435", "l": "Formation of Elongin BC complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49026", "l": "2-iminio-3-(indol-3-yl)propanoate + H2O2 => L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13791", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14775", "l": "corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine => 2 NADPH + palmatine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10927", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74458", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40909", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008459", "l": "chondroitin 6-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62328", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71287", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) = chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36976", "l": "AMP + phosphate => adenine + alpha-D-ribose 1,5-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15896", "l": "Co-sirohydrochlorin + 2 H(+) <=> Co(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56271", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24666", "l": "H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23076", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH", "d": [], "t": []}, {"i": "EC:1.21.1.2", "l": "\"2,4-dichlorobenzoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62892", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013020", "l": "Activation of GIRK/Kir3 Channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57910", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP => ATP + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033744", "l": "L-methionine:thioredoxin-disulfide S-oxidoreductase activity", "d": ["Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672951", "l": "Inactive RAFs bind YWHAB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26216", "l": "9alpha-copalyl diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46593", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35215", "l": "H2O + XDP = H(+) + phosphate + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25966", "l": "benzil + H(+) + NADPH => (R)-benzoin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25918", "l": "6-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-6-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007582", "l": "RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18595", "l": "hexadecanal + phosphoethanolamine => sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36267", "l": "caffeine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.534762107606241", "identifiers": [{"i": "GO:0016279", "l": "protein-lysine N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019142", "l": "2-hydroxyglutarate synthase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58541", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72708", "l": "GDP-beta-L-fucose(in) + GMP(out) => GDP-beta-L-fucose(out) + GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050257", "l": "riboflavin phosphotransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070644", "l": "vitamin D response element binding", "d": ["Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49799", "l": "an N-(fatty acyl)-glycine + H2O <=> a fatty acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20585", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": [], "t": []}, {"i": "EC:1.14.19.62", "l": "\"secologanin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.300845054119293", "identifiers": [{"i": "GO:0016831", "l": "carboxy-lyase activity", "d": ["Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37140", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69027", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 <=> H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070540", "l": "stearic acid binding", "d": ["Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12305", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) => 2 H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31230", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine <=> di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58654", "l": "rifamycin SV para-naphthoquinone carboxamide => rifamycin SV ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41625", "l": "3-sulfinopropanoyl-CoA + H2O => H(+) + propanoyl-CoA + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199587", "l": "KIR2DS1 interacting with HLA-C group 2 (Cw4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682388", "l": "Autophagosome maturation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76864", "l": "benzylamine + H2O + NAD(+) => benzaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49755", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NAD(+) + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.24", "l": "\"nucleoside phosphoacylhydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29183", "l": "menaquinol-8 + 2 O2 = 2 H(+) + menaquinone-8 + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29563", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}, {"i": "EC:6.3.2.45", "l": "\"UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37668", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161293", "l": "Tropoelastin forms aggregate globules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204303", "l": "MRE11 binds cytosolic DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.-", "l": "\"Forming carbon-carbon bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381608", "l": "cAMP activates EPAC2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046899", "l": "nucleoside triphosphate adenylate kinase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391933", "l": "EP3 receptor can bind PGE2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12601", "l": "2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.39", "l": "\"2-aminoadipate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44585", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050833", "l": "pyruvate transmembrane transporter activity", "d": ["Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-372342", "l": "MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001691", "l": "pseudophosphatase activity", "d": ["Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0016426", "l": "tRNA (adenine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68231", "l": "glycine(in) + Na(+)(in) <=> glycine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450325", "l": "c-FOS activation by phospho ERK1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65747", "l": "2-oxoglutarate + decyl sulfate + O2 <=> CO2 + decanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61769", "l": "rebaudioside A + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218836", "l": "PTK2beta binds alphaVbeta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46524", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48435", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34458", "l": "all-trans-beta-carotene <=> 9-cis-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12083", "l": "acetyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627072", "l": "RHOQ binds GOPC:CFTR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71991", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (-)-astellatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47035", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA <=> 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66352", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) = (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11733", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B => H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29000", "l": "H(+)(out) + homoserine lactone(in) => H(+)(in) + homoserine lactone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018480", "l": "5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836435", "l": "p-PKR dimer phosphorylates SNCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191830", "l": "snRNP nuclear import and release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15008", "l": "2-oxoglutarate + gibberellin A1 + O2 <=> CO2 + gibberellin A8 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-217255", "l": "FMO1:FAD N-oxidises TAM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796079", "l": "NFE2L2 dependent ABCC3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418553", "l": "cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417890", "l": "P2Y5 receptor can bind to LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13877", "l": "a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18860", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53225", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32327", "l": "10-hydroxy-alpha-humulene + NAD(+) = H(+) + NADH + zerumbone", "d": [], "t": []}, {"i": "EC:1.1.1.326", "l": "\"zerumbone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42149", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29661", "l": "O-acetyl-L-serine(out) => O-acetyl-L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416562", "l": "p190RhoGAP binds Plexin-B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66008", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57632", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691131", "l": "CANDI binds CUL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40709", "l": "1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805943", "l": "S100A1 binds TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40216", "l": "FADH2 + O2 => FAD + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66728", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008241", "l": "peptidyl-dipeptidase activity", "d": ["Catalysis of the release of C-terminal dipeptides from a polypeptide chain."], "t": []}, {"i": "EC:3.4.15.-", "l": "\"Peptidyl-dipeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61227", "l": "H2O + L-asparagine + O2 <=> 2-oxosuccinamate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30425", "l": "(+)-delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47111", "l": "cholate + taurine <=> H2O + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473584", "l": "Collagen type III degradation by MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018493", "l": "formylmethanofuran dehydrogenase activity", "d": ["Catalysis of the reaction: N-formylmethanofuran + A + H2O + H+ = AH(2) + CO2 + methanofuran."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2512800", "l": "SCARB1:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157629", "l": "NOTCH2-ligand complex is cleaved to produce NEXT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35686", "l": "hexadecasphinganine + NADP(+) <=> 3-oxohexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757256", "l": "MCM3 binds MCM5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50873", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 => (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14208", "l": "carnosine + S-adenosyl-L-methionine <=> anserine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65640", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47680", "l": "D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11866", "l": "dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64209", "l": "an N-(fatty acyl)-L-glutamine + H2O => a fatty acid + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55407", "l": "[phosphate](n) + UTP <=> [phosphate](n+1) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879909", "l": "Activation of STAT5a/b by JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051753", "l": "mannan synthase activity", "d": ["Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29841", "l": "2-dehydro-L-idonate + H(+) + NADPH => L-idonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59038", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102306", "l": "benzil reductase [(S)-benzoin-forming] activity", "d": ["Catalysis of the reaction: (S)-benzoin + NADP(3-) = benzil + NADPH(4-) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20796", "l": "aldehydo-D-ribose = D-ribulose", "d": [], "t": []}, {"i": "EC:5.3.1.20", "l": "\"ribose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009488", "l": "IL34 binds CSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46407", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928576", "l": "RHOA:GTP binds ROCK, activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11835", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) <=> H(+) + NADH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983696", "l": "The Immunoglobulin of the BCR binds antigen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73141", "l": "lithocholate(in) => lithocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51359", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine <=> (9Z)-octadecenoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12594", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46632", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54269", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 => (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65544", "l": "a ganglioside GM1 + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865090", "l": "UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679029", "l": "C-ter TLR7 dimer binds HCQ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035167", "l": "NR1H2,3 binds the EEPD1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549304", "l": "OCT3 mediates renal clearance of organic cations (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16011", "l": "ADP + formyl phosphate => ATP + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24677", "l": "ATP + cytidine <=> ADP + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43833", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18803", "l": "(cis-prenyl)(n+1)-diphosphate + diphosphate => (cis-prenyl)n-diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64272", "l": "benzylamine + pyruvate = benzaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001065", "l": "mitochondrial single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605797", "l": "SMPD1 hydrolyzes SPHM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69140", "l": "RPA binds to the Flap (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19127", "l": "3-hydroxypyruvate + glycine => glyoxylate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58931", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol <=> (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749253", "l": "Formation of MCM2-7 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222417", "l": "TrxA reactivates AhpC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374909", "l": "Catabolism of Noradrenaline (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202127", "l": "eNOS synthesizes NO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371467", "l": "SIRT1 deacetylates HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14649", "l": "demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.318", "l": "\"demethyllactenocin mycarosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754130", "l": "CDK4 inhibitors bind CDK4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64994", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine => acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32999", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.114", "l": "\"amorpha-4,11-diene 12 monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74119", "l": "delphinidin + UDP-alpha-D-galactose = delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016934", "l": "extracellularly glycine-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}, {"i": "REACT:R-HSA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64263", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine <=> CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879907", "l": "Tyrosine kinases phosphorylate the receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2484822", "l": "Kinetochore assembly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53941", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855648", "l": "SALM3 binds LAR-RPTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43222", "l": "H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47351", "l": "a butanoate ester + H2O <=> an aliphatic alcohol + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32705", "l": "8-hydroxycopalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389523", "l": "BTLA interacts with HVEM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062183", "l": "all-trans retinoic acid 18-hydroxylase activity", "d": ["Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:55856", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102295", "l": "4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity", "d": ["Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA = 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741395", "l": "CARD9 binds RIP2 (and NOD2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19111", "l": "1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+) => 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12577", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14415", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) => biphenyl-2,3-diol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73800", "l": "dimethylallyl diphosphate + isoechinulin A => dehydroechinulin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39658", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28510", "l": "arbutin 6-phosphate + H2O = beta-D-glucose 6-phosphate + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33403", "l": "ATP + L-threonine = diphosphate + L-threonyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102627", "l": "parthenolide 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: parthenolide + NADPH + O2 + H+ = 3beta-hydroxyparthenolide + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24279", "l": "acetate + diphosphate <=> acetyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187506", "l": "Translocation of p27 to the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17020", "l": "acetyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] <=> CoA + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015168", "l": "glycerol transmembrane transporter activity", "d": ["Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76930", "l": "3-aminopentane + H2O + NADP(+) <=> H(+) + NADPH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52148", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose = an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264435", "l": "Dissociation of the COP1-p53 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730856", "l": "Autophosphorylation of PAK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37506", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682598", "l": "ATM phosphorylates HERC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33691", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68603", "l": "ORC5 binds ORC2:ORC3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14952", "l": "A + H2O + quinoline-4-carboxylate <=> 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68438", "l": "(3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25276", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009541", "l": "ESR1 binds to TFF1 gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56172", "l": "FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58182", "l": "all-trans-lycopaoctaene + diphosphate + NADP(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47689", "l": "cis-4-hydroxy-L-proline + NADP(+) => Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018792", "l": "bis(4-chlorophenyl)acetate decarboxylase activity", "d": ["Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77201", "l": "3beta-sulfo-5-cholenate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-hydroxy-5-cholenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114354", "l": "SMAC binds XIAP:Caspase-7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23498", "l": "5-hydroxy-pentanoyl-CoA + acetate => 5-hydroxypentanoate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18642", "l": "a menaquinone + H2 => a menaquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449087", "l": "CD4 binds Interleukin-16 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49291", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> AMP + diphosphate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434836", "l": "Syk/Lck phosphorylate LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76617", "l": "acetyl-CoA + H(+) + hydrogencarbonate + NADH => 3-oxopropanoate + CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31672", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31741", "l": "a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyisoflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50678", "l": "N-terminal L-aspartyl-[protein] + NH4(+) => H(+) + H2O + N-terminal L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983158", "l": "Trimming of peptides in ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51954", "l": "2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26114", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54733", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50560", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15733", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": [], "t": []}, {"i": "EC:1.17.99.3", "l": "\"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38201", "l": "19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24561", "l": "acetyl-CoA + L-serine => CoA + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23059", "l": "urea <=> cyanamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26171", "l": "3-fumarylpyruvate + H2O <=> fumarate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654571", "l": "Activated FGFR1 binds FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.5", "l": "\"beta-aspartyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034870", "l": "pinacolone 5-monooxygenase activity", "d": ["Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034858", "l": "2-hydroxybenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10383", "l": "diphosphate + orotidine 5'-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.233", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783880", "l": "PIPOX oxidises PPCA to P6C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617641", "l": "MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41904", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19840", "l": "D-sorbitol 6-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47445", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA => (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14367", "l": "CO2 + L-aspartate + NH4(+) => 2 H(+) + H2O + N-carbamoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11142", "l": "D-mannose 6-phosphate => alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687107", "l": "MAPK4,6 translocate to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18262", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine => acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74892", "l": "CO2(out) => CO2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62169", "l": "H2O + N,N'-diacetylchitobiose => acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60523", "l": "2 H2O + L-cystine-bis-glycine <=> 2 glycine + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33195", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807585", "l": "BPI binds LPS on the bacterial surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2399913", "l": "atRAL binds to RBP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71160", "l": "H(+)(in) + L-serine(out) + Na(+)(out) => H(+)(out) + L-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35425", "l": "an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852010", "l": "BTNL2 binds activated T cells surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57603", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12858", "l": "(2S,3S)-3-methyl-L-aspartate => L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41966", "l": "(2E)-butenoyl-CoA + H2O2 => butanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11395", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050479", "l": "glyceryl-ether monooxygenase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382058", "l": "Nck binds to the active PDGF receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15374", "l": "columbamine + S-adenosyl-L-methionine => H(+) + palmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004571", "l": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0009679", "l": "hexose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29099", "l": "a menaquinone + 5 H(+)(in) + NADH = a menaquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61873", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.9", "l": "\"glucose-6-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23746", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate => 2-oxoglutarate + L-histidinol phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53887", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate <=> alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103086", "l": "methylthiopentylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(5'-methylthio)pentylmalate = 3-(5'-methylthio)pentylmalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56323", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose <=> an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015436", "l": "ABC-type capsular-polysaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54956", "l": "ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16994", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928604", "l": "SFKs phosphorylate VAV2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10323", "l": "trans-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793275", "l": "CMVPP65 binds NCR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033997", "l": "inulin fructotransferase (DFA-I-forming) activity", "d": ["Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51967", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36411", "l": "7-dehydrocholesterol + hnu = calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73410", "l": "(S,S)-tartrate(in) + sulfate(out) <=> (S,S)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003696", "l": "satellite DNA binding", "d": ["Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653249", "l": "Cleavage of factor XII variant by activated thrombin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12141", "l": "a 2'-deoxyribonucleoside + ATP => a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18322", "l": "2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30658", "l": "ATP + dUMP <=> ADP + dUDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814132", "l": "GDPD5 hydrolyzes GPCho (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640862", "l": "Tankyrase binds AXIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57911", "l": "ATP + L-glutamyl-tRNA(Gln) <=> 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25680", "l": "AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys) => ATP + O-phospho-L-serine + tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28871", "l": "D-fructuronate(in) + H(+)(in) = D-fructuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804253", "l": "MDM2 ubiquitinates JMY (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.31", "l": "\"acyl-lipid (7-3)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36025", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10593", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70299", "l": "H2O + L-dehydroascorbate = 2,3-dioxo-L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58168", "l": "(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.199", "l": "\"(-)-5-epieremophilene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16714", "l": "H2O + S-succinylglutathione => glutathione + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67519", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13060", "l": "an N-acylneuraminate 9-phosphate + H2O <=> an N-acylneuraminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187575", "l": "Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090583", "l": "protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205321", "l": "Interaction of KIT and sSCF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444523", "l": "Formation of MSH1:PMS2 Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75065", "l": "chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140869", "l": "miRNA inhibitor activity via base-pairing", "d": ["Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685607", "l": "Sialic acid binds SIGLEC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67905", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] => 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21214", "l": "4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37985", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol => gamma-tocopherol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507875", "l": "Aquaporins passively transport urea into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73552", "l": "GDP(out) + UTP(in) => GDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9816389", "l": "DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015538", "l": "sialic acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59127", "l": "(S)-2,3-diaminopropanoate + ATP + citrate <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63571", "l": "beta-casomorphin-7 + H2O <=> beta-casomorphin-6 + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51529", "l": "H(+) + vanillate => CO2 + guaiacol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38405", "l": "(9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17922", "l": "D-arabinitol + NAD(+) => D-xylulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004799", "l": "thymidylate synthase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632182", "l": "PRMT1 methylates ESRs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71255", "l": "3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57526", "l": "a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+) => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004345", "l": "glucose-6-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102531", "l": "ecdysteroid-phosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015097", "l": "mercury ion transmembrane transporter activity", "d": ["Enables the transfer of mercury (Hg) ions from one side of a membrane to the other."], "t": []}, {"i": "RHEA:32815", "l": "Hg(2+)(in) = Hg(2+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010181", "l": "FMN binding", "d": ["Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43342", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22870", "l": "chloride + H(+) + S-carboxymethyl-L-cysteine => 3-chloro-L-alanine + thioglycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48168", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39189", "l": "(2E)-docosenoyl-CoA + H2O => (3R)-hydroxydocosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47499", "l": "lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75468", "l": "ethanolamine(out) + n H(+)(in) => ethanolamine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791058", "l": "Expression of Cullin-7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20382", "l": "androsterone + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170149", "l": "Translocation of active Cdc25C to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754130", "l": "CDK4 inhibitors bind CDK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29784", "l": "ATP + H2O + L-cysteine(in) => ADP + H(+) + L-cysteine(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31086", "l": "H2O + N-acetyl-D-muramoyl-L-alanine <=> L-alanine + N-acetyl-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44114", "l": "CoA + nonyl hexadecanoate => hexadecanoyl-CoA + nonan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904593", "l": "prostaglandin binding", "d": ["Binding to prostaglandin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76518", "l": "H2O + orobanchol <=> 5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.21", "l": "\"chondroitin-sulfate-ABC exolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54708", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.6", "l": "\"carboxylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186778", "l": "SHP2 binds to the active receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66327", "l": "iodide(out) <=> iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52450", "l": "16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106323", "l": "(S)-limonene 1,2-monooxygenase NADPH activity", "d": ["Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide."], "t": []}, {"i": "RHEA:26085", "l": "(4S)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297444", "l": "Binding of cAMP to HCN channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11265", "l": "H(+) + NADH + O2 => H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186780", "l": "PI3-kinase binds to the active receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39287", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine = dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": [], "t": []}, {"i": "EC:2.1.1.250", "l": "\"[trimethylamine--corrinoid protein] Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39525", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10447", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32537", "l": "4-hydroxy-2-oxohexanoate => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334152", "l": "DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33699", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444661", "l": "HCAR2 binds HCAR2 ligands (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11951", "l": "4-hydroxybenzoyl-CoA + H2O <=> 4-hydroxybenzoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24875", "l": "D-serine + phosphate => H2O + O-phospho-D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32911", "l": "sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19279", "l": "AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl) => ATP + L-pyrrolysine + tRNA(Pyl)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75247", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50019", "l": "H2O + octanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199935", "l": "MSK1 activates CREB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211874", "l": "CYP2S1 4-hydroxylates atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68154", "l": "a triacylglycerol + CoA => a 1,3-diacylglycerol + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24100", "l": "diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.1.8.2", "l": "\"diisopropyl-fluorophosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701507", "l": "PTPN6 dephosphorylates JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102495", "l": "GA5 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate = gibberellin A3 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34679", "l": "ATP + methylphosphonate = adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": [], "t": []}, {"i": "EC:2.7.8.37", "l": "\"alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47041", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] => 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688456", "l": "MLKL binds FLOT1, FLOT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900750", "l": "oligopeptide binding", "d": ["Binding to an oligopeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050074", "l": "malate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69035", "l": "N,N-dihydroxy-L-aspartate <=> (2S)-2-nitrosobutanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36087", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77463", "l": "furan-3-carbaldehyde + hydrogen cyanide = (2S)-2-(furan-3-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13447", "l": "(R)-pantothenate + cysteamine => (R)-pantetheine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55232", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35781", "l": "mutildienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388900", "l": "Neurotensin receptors can bind neurotensins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423694", "l": "AFBDHD hydrolyses non-enzymatically to AFBDHO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29703", "l": "L-valine(in) = L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57068", "l": "3-oxoisoapionate + ATP = 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.231", "l": "\"3-oxoisoapionate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57982", "l": "(20S)-ginsenoside F1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52595", "l": "deoxycholoyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51017", "l": "7,8-dihydroneopterin 3'-phosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71544", "l": "5-hydroxymethyl-dUMP in DNA + ATP => 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42043", "l": "a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose <=> a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63159", "l": "H2O + N-docosanoyl-taurine <=> docosanoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67481", "l": "2-oxoglutarate + O2 + prekainate => CO2 + H2O + kainate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66626", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140777", "l": "protein-containing complex stabilizing activity", "d": ["A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202111", "l": "AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016751", "l": "S-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36900", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110311", "l": "POLZ extends translesion synthesis (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52505", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209309", "l": "Phosphorylated REL-68 transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50273", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37019", "l": "A + D-serine + H2O = 3-hydroxypyruvate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17605", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine = ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.25", "l": "\"tubulin--tyrosine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53562", "l": "18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11318", "l": "a nitrile + H2O => an aliphatic aldoxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0023025", "l": "MHC class Ib protein complex binding", "d": ["Binding to a class Ib major histocompatibility complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31984", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38725", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16970", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72167", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) = 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75605", "l": "plasmodiophorol A => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40393", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + CoA => 1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31486", "l": "soyasapogenol E + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080071", "l": "indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120286", "l": "tryptophan sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18537", "l": "H2O + NAD(+) + salicylaldehyde = 2 H(+) + NADH + salicylate", "d": [], "t": []}, {"i": "EC:1.2.1.65", "l": "\"salicylaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10360", "l": "3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.35", "l": "\"dihydrocoumarin hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74572", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41963", "l": "a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose <=> a ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032422", "l": "purine-rich negative regulatory element binding", "d": ["Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34789", "l": "a 3-oxosteroid + H(+) + NADPH => a 3beta-hydroxysteroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12864", "l": "guanosine + H(+) + H2O <=> NH4(+) + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018596", "l": "dimethylsilanediol hydroxylase activity", "d": ["Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51423", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57995", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350186", "l": "CUBN binds GC:25(OH)D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169398", "l": "ISGylation of host protein filamin B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944457", "l": "MAF1 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64379", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30135", "l": "dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209049", "l": "Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19986", "l": "NAD(+) + S-(hydroxymethyl)glutathione => H(+) + NADH + S-formylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25990", "l": "albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23959", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19388", "l": "UDP-alpha-D-glucose + vomilenine <=> H(+) + raucaffricine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53218", "l": "16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24392", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": [], "t": []}, {"i": "EC:2.4.2.27", "l": "\"dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685156", "l": "ATR phosphorylates RPA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47064", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43074", "l": "erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51006", "l": "an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome cL]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49053", "l": "asperlicin C + H(+) + NADH + O2 => asperlicin E + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050132", "l": "N-methylalanine dehydrogenase activity", "d": ["Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = H+ + methylammonium + NADPH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74360", "l": "coproporphyrin I(out) => coproporphyrin I(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559439", "l": "CD14:LPS binds CR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20126", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9698844", "l": "MLKL binds HSP90:CDC37 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54494", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426569", "l": "Interaction of DAP12 and IREM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196773", "l": "COASY phosphorylates DP-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58762", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27501", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine = 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76919", "l": "4-methyl-cyclohexylamine + H2O + NADP(+) = 4-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102663", "l": "gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 = H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106032", "l": "snRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: uridine in snRNA = pseudouridine in snRNA. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."], "t": []}, {"i": "RHEA:51124", "l": "uridine in snRNA = pseudouridine in snRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461993", "l": "pro-HD5 is cleaved by trypsin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850786", "l": "SPINK6 binds KLK12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36280", "l": "H(+) + NADH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635845", "l": "GLI proteins bind CDC73 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70899", "l": "histidine => urocanate + NH4+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50669", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160082", "l": "hypoxia-inducible factor-proline dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71096", "l": "2 Na(+)(out) + pregnenolone sulfate(out) => 2 Na(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39892", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + H(+) + vancomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38989", "l": "(2E)-nonenoyl-CoA + H2O2 => nonanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31911", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24863", "l": "H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP => pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23523", "l": "acetyl-CoA + propanoate <=> acetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55297", "l": "13-cis-retinol + hexadecanoyl-CoA => 13-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42539", "l": "uridine(65) in tRNA <=> pseudouridine(65) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10572", "l": "vinylacetyl-CoA = (2E)-butenoyl-CoA", "d": [], "t": []}, {"i": "EC:5.3.3.3", "l": "\"vinylacetyl-CoA Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102589", "l": "cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) = cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:1903763", "l": "gap junction channel activity involved in cell communication by electrical coupling", "d": ["Any gap junction channel activity that is involved in cell communication by electrical coupling."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876446", "l": "p-ULK1 phosphorylates DENND3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937613", "l": "CRHBP binds CRH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38457", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55795", "l": "butan-2-one + H(+) + NADH + O2 <=> 1-hydroxy-2-butanone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15413", "l": "(2R,3R)-tartrate = H2O + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.2.1.32", "l": "\"L(+)-tartrate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050003", "l": "deoxycytidylate C-methyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43574", "l": "5-guanidino-2-oxopentanoate + AH2 + NH4(+) => A + D-arginine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51334", "l": "11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218822", "l": "CRK binds BCAR1 and or PXN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371527", "l": "HSF1 trimer translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13349", "l": "jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.141", "l": "\"jasmonate O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0052841", "l": "inositol bisdiphosphate tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: bisdiphospho-1D-myo-inositol tetrakisphosphate + H2O = diphospho-1D-myo-inositol pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671829", "l": "JAK2 Phosphorylates STAT5 in Response to Leptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57970", "l": "8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938108", "l": "SERPINB13 binds cathepsin L (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13781", "l": "an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.2", "l": "\"L-amino-acid oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626938", "l": "Beta-catenin binds SOX proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60566", "l": "2-deoxy-D-glucose 6-phosphate + ADP + H(+) => 2-deoxy-D-glucose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42415", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) <=> ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19674", "l": "1,2,3-trihydroxybenzene + O2 => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70971", "l": "citrate <=> isocitrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55041", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70816", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) => H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25516", "l": "an acyl-CoA + tropine = CoA + H(+) + O-acyltropine", "d": [], "t": []}, {"i": "EC:2.3.1.185", "l": "\"tropine acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66289", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55097", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O => (3S)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514790", "l": "Elastin degradation by MMP14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64351", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) <=> deacetylpyripyropene E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28371", "l": "oxaloacetate + phosphate => hydrogencarbonate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004128", "l": "cytochrome-b5 reductase activity, acting on NAD(P)H", "d": ["Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072572", "l": "poly-ADP-D-ribose binding", "d": ["Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371467", "l": "SIRT1 deacetylates HSF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362485", "l": "GHBP binds GH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69493", "l": "O2 + octan-1-ol => H2O2 + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944227", "l": "Association of procollagen type XXII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592297", "l": "Full activation of MMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14185", "l": "3-phenylpyruvate + H(+) = 2-phenylacetaldehyde + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.43", "l": "\"phenylpyruvate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36510", "l": "docosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68071", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13013", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.87", "l": "\"N-acetyllactosaminide 3-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31332", "l": "ATP + H(+) + molybdopterin => adenylyl-molybdopterin + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76577", "l": "5-dehydro-4-deoxy-D-glucuronate => 4-deoxy-L-threo-hex-4-enopyranuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44115", "l": "hexadecanoyl-CoA + nonan-1-ol <=> CoA + nonyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24711", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose => L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653974", "l": "Ragulator binds Rag dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17125", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine = 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52200", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68939", "l": "ATP + H(+) + NADPH + nonanoate <=> AMP + diphosphate + NADP(+) + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48458", "l": "2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236970", "l": "Proteasomal clevage of exogenous antigen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161282", "l": "Elastic fibres bind associated proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421835", "l": "trans-Golgi Network Vesicle Scission (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010385", "l": "double-stranded methylated DNA binding", "d": ["Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14525", "l": "A + beta-cyclopiazonate = AH2 + alpha-cyclopiazonate", "d": [], "t": []}, {"i": "EC:1.21.99.1", "l": "\"beta-cyclopiazonate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-877281", "l": "PIAS1 binds p-STAT1 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029270", "l": "Recruitment of PLCgamma to membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0016163", "l": "nitrogenase activity", "d": ["Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0140297", "l": "DNA-binding transcription factor binding", "d": ["Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12893", "l": "prostaglandin H2 = prostaglandin E2", "d": [], "t": []}, {"i": "EC:5.3.99.3", "l": "\"prostaglandin-E synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35857", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928656", "l": "gamma-secretase cleaves EPHB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25354", "l": "H2O + L-cysteinyl-tRNA(Pro) <=> H(+) + L-cysteine + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708866", "l": "pro-F2R binds vorapaxar (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.1", "l": "\"DNA topoisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627078", "l": "XIAP binds CASP9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16300", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.16", "l": "\"ABC-type ferric hydroxamate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49400", "l": "H2O + validoxylamine A 7'-phosphate = phosphate + validoxylamine A", "d": [], "t": []}, {"i": "EC:3.1.3.101", "l": "\"validoxylamine A 7'-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20536", "l": "H2O + pyridoxal 5'-phosphate <=> phosphate + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725855", "l": "NR3C2 binds NR3C2 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003973", "l": "(S)-2-hydroxy-acid oxidase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27976", "l": "7-carboxy-7-deazaguanine + NH4(+) => 6-carboxy-5,6,7,8-tetrahydropterin + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390597", "l": "Release Of ADP From Myosin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11548", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.54", "l": "\"acetoxybutynylbithiophene deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55460", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179410", "l": "Association of Nek2A with MCC:APC/C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40679", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420688", "l": "GABAB heterodimeric receptor binds GABA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852337", "l": "GTSE1 binds TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944227", "l": "Association of procollagen type XXII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39413", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50898", "l": "(8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate => 8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32754", "l": "choline(out) <=> choline(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37074", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45048", "l": "acetamide + H2O = acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203979", "l": "Coat Assembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45964", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O = 2 AMP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27388", "l": "H2O + maleamate <=> maleate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71463", "l": "H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14764", "l": "H(+) + hexadecanoyl-CoA + L-serine <=> 3-oxosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68952", "l": "isoscopoletin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27629", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate <=> beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050316", "l": "T2-induced deoxynucleotide kinase activity", "d": ["Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.246", "l": "\"4beta-methylsterol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003938", "l": "IMP dehydrogenase activity", "d": ["Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.30", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.32", "l": "\"brachyurin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19446", "l": "2,3-dihydroxyindole + O2 => anthranilate + CO2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49407", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54615", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 <=> 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031827", "l": "type 2B serotonin receptor binding", "d": ["Binding to a type 2B serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57790", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,3-dinitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54677", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-kolavenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51916", "l": "(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928617", "l": "EPHB2 binds KALRN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35062", "l": "chloramphenicol(in) + H(+)(out) <=> chloramphenicol(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16919", "l": "2,3,6-trihydroxypyridine + H2O + NAD(+) => 2,6-dihydroxypyridine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60452", "l": "2-hydroxyethane-1-sulfonate = acetaldehyde + H(+) + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.38", "l": "\"isethionate sulfite-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31295", "l": "(2E)-2-hydroxypenta-2,4-dienoate = 2-oxopent-4-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44763", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659782", "l": "Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40583", "l": "H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18999", "l": "CDP-choline + diphosphate => CTP + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420724", "l": "CASR binds Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59006", "l": "dodecanoate + H(+) + H2O2 => dodecanal + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815510", "l": "MIB2 binds CYLD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67963", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine <=> 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980056", "l": "JAG1 binds NOTCH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102769", "l": "dihydroceramide glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.7", "l": "\"plasmin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16853", "l": "N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110319", "l": "Elongation by POLH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22981", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16083", "l": "(2R)-S-methyl-1-thioglycerate + phosphate => (2R)-S-methyl-3-phospho-1-thioglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36073", "l": "D-glucose + tulipalin A => 6-tuliposide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797090", "l": "CCNK binds CDK12 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.37", "l": "\"1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47733", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353460", "l": "REV1-Pol kappa complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71981", "l": "diphosphate + fusoxypene A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA => 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018541", "l": "p-benzoquinone reductase (NADPH) activity", "d": ["Catalysis of the reaction: 1,4-benzoquinone + H+ + NADPH = hydroquinone + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450494", "l": "HuR binds mRNAs in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034547", "l": "N-cyclopropylmelamine deaminase activity", "d": ["Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14631", "l": "ADP + N-acetyl-L-glutamyl 5-phosphate => ATP + N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20886", "l": "3-hydroxypyruvate + H(+) + NADH + NH4(+) => H2O + L-serine + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008597", "l": "calcium-dependent protein serine/threonine phosphatase regulator activity", "d": ["Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase."], "t": []}, {"i": "REACT:R-HSA-139906", "l": "Activation of BAD by calcineurin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626220", "l": "C2CD3 binds the mother centriole (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47256", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011543", "l": "DCA binds PDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199587", "l": "KIR2DS1 interacting with HLA-C group 2 (Cw4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30788", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17871", "l": "6,7-dihydropteridine + H(+) + NADH => 5,6,7,8-tetrahydropteridine + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641205", "l": "RSPO:LGR binds ZNRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63226", "l": "2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018129", "l": "peptidyl-oxazoline dehydrogenase activity", "d": ["Catalysis of the reduction of a peptide-linked oxazoline to oxazole."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670014", "l": "Factor VIIIa dissociates  (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19528", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,8aR)-delta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16294", "l": "2-isopropylmaleate + H2O => (2S)-2-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67003", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisobutanophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60750", "l": "CoA + pyrethrin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668404", "l": "TNFA binds TNFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14582", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH => 2 L-ascorbate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74723", "l": "Endosome acidification (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12894", "l": "prostaglandin H2 => prostaglandin E2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470011", "l": "Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20474", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52512", "l": "a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": [], "t": []}, {"i": "EC:1.5.5.3", "l": "\"hydroxyproline dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40163", "l": "D-glyceraldehyde + H2O + NADP(+) = (R)-glycerate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.89", "l": "\"D-glyceraldehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59655", "l": "D-xylotetraono-1,5-lactone + H2O <=> D-xylotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60861", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12931", "l": "(2R)-homocitrate + CoA + H(+) => 2-oxoglutarate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19417", "l": "[phosphate](n) + a dolichyl diphosphate = [phosphate](n+1) + a dolichyl phosphate", "d": [], "t": []}, {"i": "EC:2.7.4.20", "l": "\"dolichyl-diphosphate--polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70233", "l": "(S)-2-benzoylsuccinyl-CoA + H(+) + NADH => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68987", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008797", "l": "aspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: L-aspartate = fumarate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23504", "l": "adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": [], "t": []}, {"i": "EC:3.5.1.90", "l": "\"adenosylcobinamide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166753", "l": "Conversion of C4 into C4a and C4b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16503", "l": "H(+) + myo-inositol + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163602", "l": "2 phosphorylated HSL monomers -> phosphorylated HSL dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28254", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA = (3Z)-hex-3-en-1-yl acetate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.195", "l": "\"(Z)-3-hexen-1-ol acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17471", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein] => a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40645", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59557", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone => H(+) + N,N'-diacetylchitobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52283", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418553", "l": "cAMP degradation by Phosphodiesterases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018741", "l": "linear primary-alkylsulfatase activity", "d": ["Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O =>a primary alcohol + H(+) + sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18832", "l": "4-phospho-D-erythronate + NAD(+) <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391158", "l": "SIRP alpha binds CD47 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380930", "l": "Phosphorylated AMPK binds AMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702818", "l": "CALCR binds erenumab (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50547", "l": "prostaglandin C2 <=> prostaglandin B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36020", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047784", "l": "cortisol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400382", "l": "CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45566", "l": "5-epi-valiolone => 2-epi-5-epi-valiolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683964", "l": "ATM phosphorylates EYA1-4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42299", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645598", "l": "RRAGC,D hydrolyzes GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951727", "l": "cAMP binds PKA tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793628", "l": "Cipro is imported by organic cation transporters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71203", "l": "L-homoarginine(in) = L-homoarginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64856", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + phomopsene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685319", "l": "CX3 complex formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48119", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58870", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693783", "l": "NAALADases hydrolyse NAAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57142", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815510", "l": "MIB2 binds CYLD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76052", "l": "Binding of TFIIIA To type 1 Promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399939", "l": "Autophosphorylation of PAK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42289", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine => (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29240", "l": "H(+)(in) + uracil(in) => H(+)(out) + uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34377", "l": "4-guanidinobutanoate + NH4(+) => 4-guanidinobutanamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52854", "l": "6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950583", "l": "STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42125", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => androsterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27578", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + tert-butylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210444", "l": "L-Glutamate loading of synaptic vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46654", "l": "5beta-dihydroepitestosterone + NADP(+) => epitestosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047335", "l": "3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity", "d": ["Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36938", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16066", "l": "2-oxoglutarate + O2 + phytanoyl-CoA => 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29067", "l": "formate + H(+) + menaquinone-8 = CO2 + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164617", "l": "Elongation of Extended Telomeric Chromosome End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71008", "l": "L-phenylalanine(out) + L-tryptophan(in) => L-phenylalanine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901707", "l": "leptomycin B binding", "d": ["Binding to leptomycin B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39890", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27471", "l": "acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59523", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0008271", "l": "secondary active sulfate transmembrane transporter activity", "d": ["Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71968", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217255", "l": "FMO1:FAD N-oxidises TAM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66969", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106615", "l": "Removal of siRNA passenger strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57734", "l": "AH2 + all-trans-retinol => A + all-trans-7,8-dihydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210439", "l": "glutamate uptake by astrocytes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51309", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 => H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26534", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.36", "l": "\"3-hydroxypropionyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047721", "l": "indoleacetate-lysine synthetase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34575", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": [], "t": []}, {"i": "EC:1.14.19.8", "l": "\"pentalenolactone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411383", "l": "NLK phosphorylates TCF/LEF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25336", "l": "H(+) + L-cysteine + tRNA(Cys) => H2O + L-cysteinyl-tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.63", "l": "\"beta-amyrin 16beta-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748996", "l": "GST dimers cleave AZA to 6MP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799761", "l": "TP53 binds PPP1R13L (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48832", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102591", "l": "delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose = delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38545", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein] => H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700179", "l": "Ligand-independent dimerization of ALK fusions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13745", "l": "ascopyrone M = microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45767", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) <=> 2 H(+) + L-aspartate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034191", "l": "apolipoprotein A-I receptor binding", "d": ["Binding to an apolipoprotein A-I receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759158", "l": "SQSTM1 oligomerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39630", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA <=> (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419428", "l": "S1PR2-5 bind S1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0061922", "l": "histone propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940959", "l": "Neurolysin degrades neurotensin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102076", "l": "beta,beta-carotene-9',10'-cleaving oxygenase activity", "d": ["Catalysis of the reaction: beta-carotene + O2 = 10'-apo-beta-carotenal + beta-ionone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16193", "l": "an (R)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36998", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23785", "l": "a quinone + L-proline => (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49545", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O => 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23155", "l": "a ubiquinone + H(+) + NADH <=> a ubiquinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39688", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA => (2E,11Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24274", "l": "H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983700", "l": "SYK binds the activated BCR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450551", "l": "AUF1 binds translation and heat shock proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51143", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016002", "l": "sulfite reductase activity", "d": ["Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74268", "l": "n H(+)(out) + spermidine(in) => n H(+)(in) + spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42837", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH => 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941895", "l": "Formation of CDK4/6:CCND complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53172", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22676", "l": "chlorophyllide a + H(+) + NADPH + O2 = 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617179", "l": "PRKACA phosphorylates TNNI3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047631", "l": "ADP-ribose diphosphatase activity", "d": ["Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36236", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15100", "l": "5-formimidoyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35090", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate <=> D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38580", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58811", "l": "2',3'-cGAMP + 2 H2O <=> AMP + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995388", "l": "PP2A dephosphorylates BANF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48692", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37319", "l": "ATP + glycyl-L-methionine(out) + H2O = ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61138", "l": "CO2 + H(+) + H2O + quercetin + succinate => (2R,3R)-dihydroquercetin + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31631", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate = phosphate + pseudaminate", "d": [], "t": []}, {"i": "EC:2.5.1.97", "l": "\"pseudaminic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373713", "l": "DCC heterodimerizes with UNC-5:Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53309", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39755", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17583", "l": "an L-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18862", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine => a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050079", "l": "acetylenecarboxylate hydratase activity, producing 3-oxopropanoate", "d": ["Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27465", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.70", "l": "\"D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27727", "l": "5-dehydro-4-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61690", "l": "AMP + diphosphate + L-threonyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38555", "l": "an all-trans-retinyl ester + H2O = a fatty acid + all-trans-retinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57274", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26448", "l": "H(+) + malonyl-CoA + NADPH => 3-oxopropanoate + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201630", "l": "Caspase-mediated cleavage of Acinus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061662", "l": "ISG15 ligase activity", "d": ["Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S = X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785711", "l": "Telomere shortening during replicative exhaustion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64270", "l": "emodin + H(+) + H2O => emodin anthrone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23558", "l": "gamma-L-glutamyl-D-alanine + NH4(+) => D-alanine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35358", "l": "3-hydroxyisopentadecanoyl-CoA <=> (2E)-13-methyltetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.31", "l": "\"DNA nucleotidylexotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707594", "l": "Hemes bind LY96 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102404", "l": "linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "d": ["Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O = vicianose + linalool."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30938", "l": "H2O + nicotinate beta-D-ribonucleotide <=> beta-D-ribosylnicotinate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0035381", "l": "ATP-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77589", "l": "Recognition of AAUAAA sequence by CPSF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707683", "l": "PGRMC2 binds Hemes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57958", "l": "dimethyl sulfone + H2O + NAD(+) => dimethyl sulfoxide + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58747", "l": "H2O + N(7)-methyl-GTP <=> diphosphate + H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42690", "l": "A + ergothioneine + NH4(+) + pyruvate => AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52792", "l": "chlorophyllide a + 2 H(+) = Mg(2+) + pheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627078", "l": "XIAP binds CASP9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68372", "l": "L-asparagine + pyruvate = 2-oxosuccinamate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.-", "l": "\"Other oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373707", "l": "Netrin-1 induced DCC clustering (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706350", "l": "FLT3 phosphorylates CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36019", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71834", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) <=> chloride(in) + creatine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64030", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17711", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27298", "l": "2-formylbenzoate + H2O + NAD(+) = 2 H(+) + NADH + phthalate", "d": [], "t": []}, {"i": "EC:1.2.1.78", "l": "\"2-formylbenzoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54373", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(2S,3R,9R)-pristinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44003", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 <=> 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57993", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65710", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-beta-L-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64617", "l": "(E)-coniferol + acetyl-CoA => (E)-coniferyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39896", "l": "7-deoxyloganetate + UDP-alpha-D-glucose => 7-deoxyloganate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28626", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39007", "l": "a cholesterol ester(in) = a cholesterol ester(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71756", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) => 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73778", "l": "dimethylallyl diphosphate + preechinulin <=> diphosphate + tardioxopiperazine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41450", "l": "(4S)-4-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449077", "l": "Interleukin-16 is secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12405", "l": "D-glucose + UDP-alpha-D-galactose => H(+) + lactose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354124", "l": "Phosphorylation of pPTK2 by SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52501", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57004", "l": "acetyl-CoA + streptothricin D = CoA + H(+) + N(beta)-acetylstreptothricin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032183", "l": "SUMO binding", "d": ["Binding to the small ubiquitin-like protein SUMO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71625", "l": "malonate(in) + phosphate(out) => malonate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15661", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside = an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.153", "l": "\"anthocyanin 5-(6'''-hydroxycinnamoyltransferase)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43187", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA <=> H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16242", "l": "an NDP-alpha-D-glucose + D-fructose => a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865107", "l": "MICAL1 produces NADP+, H2O2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21129", "l": "S-adenosyl-L-methionine + zymosterol => fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52916", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005519", "l": "cytoskeletal regulatory protein binding", "d": ["Binding to a protein involved in modulating the reorganization of the cytoskeleton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426223", "l": "Cation influx mediated by TRPC3/6/7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27921", "l": "H2O + NADP(+) + propanal <=> 2 H(+) + NADPH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20874", "l": "(20S)-ginsenoside Rb1 + H(+) + UDP => (20S)-ginsenoside Rd + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624798", "l": "LBR binds KPNB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961846", "l": "CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761421", "l": "CDH11 associates with catenins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35924", "l": "neamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31808", "l": "(2E,6E)-farnesyl diphosphate => alpha-guaiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30794", "l": "dGTP + pyruvate <=> dGDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62830", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18869", "l": "ATP + L-xylulose = ADP + H(+) + L-xylulose 5-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.53", "l": "\"L-xylulokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76463", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20011", "l": "H(+) + linamarin + UDP => 2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.222", "l": "\"2-polyprenyl-6-hydroxyphenol methylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12335", "l": "ATP + Fe(3+)(out) + H2O <=> ADP + Fe(3+)(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3244643", "l": "STING binds cyclic GMP-AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636304", "l": "Mce3E binds MAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53121", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.134", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333607", "l": "GSSeH combines with bGalNAc derivative to form GSSebGalNac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001784", "l": "phosphotyrosine residue binding", "d": ["Binding to a phosphorylated tyrosine residue within a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43024", "l": "an S-substituted L-cysteine = 2-aminoprop-2-enoate + a thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70356", "l": "1-carboxybiuret + H(+) => biuret + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28243", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] => 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43010", "l": "2-aminoprop-2-enoate + H2O => D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662614", "l": "MT1E binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.221", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014812", "l": "ROBOs bind keratan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0120014", "l": "phospholipid transfer activity", "d": ["Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10717", "l": "D-glucose 6-phosphate => 1D-myo-inositol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52866", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75664", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44188", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004965", "l": "G protein-coupled GABA receptor activity", "d": ["Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54906", "l": "(9Z)-hexadecenoyl-[ACP] + NAD(+) => (2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18040", "l": "agmatine + H2O <=> N-carbamoylputrescine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388832", "l": "PI3K binds CD28 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381668", "l": "cAMP activates EPAC1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710354", "l": "GSDME (1-270) binds cardiolipin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25613", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = terpentedienyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.15", "l": "\"terpentedienyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52345", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35417", "l": "an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP => an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901480", "l": "oleate transmembrane transporter activity", "d": ["Enables the transfer of oleate from one side of a membrane to the other."], "t": []}, {"i": "RHEA:33655", "l": "(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.69", "l": "\"bontoxilysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033773", "l": "isoflavone 2'-hydroxylase activity", "d": ["Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733973", "l": "Bile salts bind FABP6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58366", "l": "a medium-chain fatty aldehyde + H(+) + NADPH => a medium-chain primary fatty alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24462", "l": "acetyl-[ACP] + CO2 => H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64874", "l": "dihydroxyacetone phosphate + glycolaldehyde => D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48236", "l": "2 2-acetylphloroglucinol = 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.272", "l": "\"2-acetylphloroglucinol acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22177", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169395", "l": "ISGylation of viral protein NS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450187", "l": "TAK1 is activated within the TAK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46944", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) = H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11220", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665408", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2870221", "l": "E-selectin binds E-selectin ligand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19546", "l": "H2O + sn-glycerol 3-phosphocholine => glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433454", "l": "Phosphorylation of GAB2 by SFKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77268", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59418", "l": "H2O2 + indole-3-acetaldehyde + NH4(+) => H2O + O2 + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35213", "l": "dIMP + H(+) + phosphate => dIDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70131", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75435", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] = 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53859", "l": "NADP(+) + ursocholate <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57924", "l": "H2O + mutildienyl diphosphate = diphosphate + premutilin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56050", "l": "daidzein 7-O-beta-D-glucoside + UDP => daidzein + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38289", "l": "(3S)-citramalyl-CoA + succinate => (3S)-citramalate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429815", "l": "Formation Of Bloc-1 Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603251", "l": "Defective ACTH does not bind MCR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158399", "l": "kallikrein binds SERPING1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34011", "l": "5-dehydroepisterol + 2 H2O + NADP(+) = ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37829", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50659", "l": "3-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0016882", "l": "cyclo-ligase activity", "d": ["Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.3.3.-", "l": "\"Cyclo-ligases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046964", "l": "3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "d": ["Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.39", "l": "\"glucan endo-1,3-beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33662", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76583", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADH = (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39040", "l": "an omega-oxo fatty acid + H2O + NAD(+) => a dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65740", "l": "2-oxoglutarate + nonyl sufate + O2 = CO2 + H(+) + nonanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23782", "l": "(2S,3S)-2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21079", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> CO2 + succinate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429101", "l": "HMIT co-transports myo-inositol with a proton (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29924", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944454", "l": "mTORC1 phosphorylates MAF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28266", "l": "(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.55", "l": "\"(S)-beta-bisabolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140836", "l": "RNA polymerase II CTD heptapeptide repeat S5 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52806", "l": "(+)-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35727", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001863", "l": "collectin receptor activity", "d": ["Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65232", "l": "3-hydroxydodecanoyl-CoA + H2O = 3-hydroxydodecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912408", "l": "Telomeres cluster at the nuclear membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49210", "l": "20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48197", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043829", "l": "tRNA-specific adenosine-37 deaminase activity", "d": ["Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254291", "l": "ERBB4s80 binds STAT5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863727", "l": "STON2 is neddylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165162", "l": "Phosphorylation of TSC2 by PKB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.7.-.-", "l": "\"Forming nitrogen-nitrogen bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032143", "l": "single thymine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036140", "l": "[protein]-asparagine 3-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163568", "l": "phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68228", "l": "glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76849", "l": "butan-2-one + H(+) + NADH + NH4(+) => (R)-sec-butylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665412", "l": "ERBB2 ECD mutants bind TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42653", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine => diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55786", "l": "all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP => all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865256", "l": "CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75745", "l": "10-hydroxy-(11E)-octadecenoate + NAD(+) => 10-oxo-(11E)-octadecenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36675", "l": "octacosanoyl-CoA + sphinganine = CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38507", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052764", "l": "exo-oligoalginate lyase activity", "d": ["Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends."], "t": []}, {"i": "EC:4.2.2.26", "l": "\"oligo-alginate lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093332", "l": "p-EPHB phosphorylates SDC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37562", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61562", "l": "gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944246", "l": "Association of procollagen type XXI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490230", "l": "AFXBO-SG, AFNBO-SG translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195378", "l": "Homodimerization of VEGF proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45268", "l": "4'-hydroxyechinenone + AH2 + O2 = 4',4'-dihydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75681", "l": "(12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18485", "l": "6-acetyl-D-glucose + H2O = acetate + D-glucose + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.33", "l": "\"6-acetylglucose deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796082", "l": "AcK-NFE2L2 binds the EGF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29328", "l": "(S)-malate(in) + succinate(out) => (S)-malate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28547", "l": "alpha-D-glucose => alpha-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936731", "l": "Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43378", "l": "5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 5'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935731", "l": "ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32943", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52487", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18587", "l": "dihydroxyacetone phosphate => D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63993", "l": "5-fluorocytidine + ATP => 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76968", "l": "a short-chain fatty aldehyde + H2O + NADP(+) => a short-chain fatty acid + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38740", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22527", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid phi-end derivative + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70123", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22727", "l": "a sterol + UDP-alpha-D-glucose <=> a sterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682020", "l": "MRN complex binds shortened telomeres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29684", "l": "alpha-maltohexaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411373", "l": "NLK translocates to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665989", "l": "DIAPH1 binds RHOA:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43090", "l": "5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine => 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37498", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13276", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol <=> 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60704", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61487", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035226", "l": "glutamate-cysteine ligase catalytic subunit binding", "d": ["Binding to the catalytic subunit of glutamate-cysteine ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203070", "l": "Association of profilin with monomeric actin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55875", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730841", "l": "Phosphorylation and activation of VAV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52722", "l": "5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+) => 5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49438", "l": "choloyl-CoA + deoxycholate => cholate + deoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63722", "l": "losartan-2-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0008384", "l": "IkappaB kinase activity", "d": ["Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57399", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine <=> 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16031", "l": "beta-alanine + urea => 3-guanidinopropanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656254", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58657", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947535", "l": "Cyclisation of GTP to precursor Z (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018573", "l": "2-aminophenol 1,6-dioxygenase activity", "d": ["Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.177", "l": "\"ultra-long-chain fatty acid omega-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141437", "l": "Formation of the MCC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68779", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606839", "l": "ARSC hydrolyzes steroid sulfates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008457", "l": "beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70157", "l": "28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20926", "l": "a [peptide]-C-terminal amide + glyoxylate => a [peptide]-C-terminal (2S)-2-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74514", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B <=> aspoquinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56319", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34177", "l": "4-hydroxycoumarin + CO2 + 2 CoA => 2-hydroxybenzoyl-CoA + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.1", "l": "\"alkaline phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42888", "l": "(R)-3-phosphomevalonate + ATP = (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.186", "l": "\"mevalonate-3-phosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15598", "l": "a Fe(III)-siderophore(out) + ATP + H2O => a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31912", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691421", "l": "BTK binds BTK inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35874", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39093", "l": "(3S)-hydroxydecanedioyl-CoA => (2E)-decenedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76906", "l": "(1S)-2-methyl-cyclohexylamine + H2O + NAD(+) <=> 2-methylcyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18057", "l": "O2 + Watasenia luciferin = CO2 + hnu + oxidized Watasenia luciferin", "d": [], "t": []}, {"i": "EC:1.13.12.8", "l": "\"Watasenia-luciferin 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51806", "l": "diphosphate + H(+) + lupulone => deoxyhumulone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15820", "l": "H2O + O2 + pyridoxamine 5'-phosphate <=> H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + verrucosan-2beta-ol", "d": [], "t": []}, {"i": "EC:4.2.3.208", "l": "\"verrucosan-2beta-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.47", "l": "\"[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14045", "l": "1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": [], "t": []}, {"i": "EC:2.7.8.23", "l": "\"carboxyvinyl-carboxyphosphonate phosphorylmutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36291", "l": "3-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66326", "l": "iodide(in) => iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612255", "l": "ERBB4s80 binds ADAP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34340", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015234", "l": "thiamine transmembrane transporter activity", "d": ["Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35115", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654569", "l": "Activated FGFR1 binds FRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53059", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786155", "l": "POLN binds ICL-DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39121", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099508", "l": "voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "d": ["Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30513", "l": "2-demethylmenaquinol-8 + NADP(+) => 2-demethylmenaquinone-8 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39961", "l": "glycerol + H(+) + hexadecanoate => 1-hexadecanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38001", "l": "H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0004340", "l": "glucokinase activity", "d": ["Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391942", "l": "IP receptor can bind prostacyclin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48551", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O <=> [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77131", "l": "1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047716", "l": "imidazole N-acetyltransferase activity", "d": ["Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28900", "l": "glycine(in) + H(+)(in) => glycine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9834807", "l": "ILF3 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45609", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83788", "l": "Binding of TFIIIC to Type 2 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956639", "l": "RUNX1 binds YAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38456", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761421", "l": "CDH11 associates with catenins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48491", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) <=> all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876446", "l": "p-ULK1 phosphorylates DENND3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006870", "l": "IL21 receptor STAT phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75634", "l": "H2O + plasmodiophorol B <=> plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944261", "l": "Association of procollagen type XIII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37424", "l": "aclacinomycin N + O2 => aclacinomycin A + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75079", "l": "Formation of AT-AC C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625409", "l": "KLF4 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55809", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828034", "l": "SOX17 binds the CXCR4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210430", "l": "Release of L-Glutamate at the synapse (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63389", "l": "2 A + Fe(II)-heme o + H2O => 2 AH2 + Fe(II)-heme a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23634", "l": "2-oxoglutarate + CO2 + NADH => D-threo-isocitrate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59141", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine => AMP + diphosphate + H(+) + staphyloferrin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70202", "l": "dopaminechrome <=> 5,6-dihydroxyindole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034479", "l": "phosphatidylglycerol phospholipase C activity", "d": ["Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38112", "l": "glycerol + NADP(+) => H(+) + L-glyceraldehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73287", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71883", "l": "GMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64534", "l": "an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008480", "l": "GSK3B phosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51161", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72920", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16868", "l": "choloyl-CoA + propanoyl-CoA <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418456", "l": "cGMP is degraded by PDEs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047649", "l": "alkylglycerol kinase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62315", "l": "salicylate + UDP-alpha-D-glucose <=> H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750942", "l": "USP14 deubiquitinates NLRC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66759", "l": "ATP + domoate(in) + H2O <=> ADP + domoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36417", "l": "diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733973", "l": "Bile salts bind FABP6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451900", "l": "IL2RB binds JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917693", "l": "ESCRT Disassembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005362", "l": "low-affinity glucose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}, {"i": "REACT:R-HSA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035299", "l": "inositol pentakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032190", "l": "acrosin binding", "d": ["Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.3", "l": "\"bacterial tyrosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944229", "l": "Association of procollagen type IX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65049", "l": "4-acetoxybenzyl alcohol + NAD(+) => 4-acetoxybenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17596", "l": "3-phenylpyruvate + L-glutamine <=> 2-oxoglutaramate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34452", "l": "dTDP-6-deoxy-beta-L-talose => dTDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55283", "l": "13-cis-retinol + tetradecanoyl-CoA <=> 13-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22992", "l": "3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.-", "l": "\"Transaminases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19124", "l": "an S-substituted glutathione(in) + ATP + H2O <=> ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57200", "l": "glyoxal + L-arginyl-[protein] = N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21060", "l": "3,4-dichloroaniline + malonyl-CoA = CoA + N-(3,4-dichlorophenyl)malonamate", "d": [], "t": []}, {"i": "EC:2.3.1.114", "l": "\"3,4-dichloroaniline N-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76429", "l": "(2R)-annullatin F + AH2 => (2R,9S)-annullatin H + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61514", "l": "malvidin 3-O-beta-D-glucoside + UDP => malvidin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102536", "l": "sakuranetin 6-hydroxylase activity", "d": ["Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ = carthamidin-7-methyl ether + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71591", "l": "2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) + malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14164", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0010851", "l": "cyclase regulator activity", "d": ["Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73618", "l": "CTP(out) + dCMP(in) <=> CTP(in) + dCMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68352", "l": "pppA(2'-5')pG = 3',2'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19086", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46263", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59586", "l": "ADP + beta-alanyl-L-lysine + H(+) + phosphate => ATP + beta-alanine + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877620", "l": "ECE2 cleaves EDN1(53-90) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205319", "l": "Interaction of APS and p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32589", "l": "(3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38170", "l": "hexadecan-1-ol + hexadecanoyl-CoA <=> CoA + hexadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35411", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.215", "l": "\"anthocyanidin 3-O-glucoside 6''-O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199169", "l": "MHC Class I interacts with CD160 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77300", "l": "a ubiquinone + H2O + theobromine => 3,7-dimethylurate + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0050492", "l": "glycerol-1-phosphate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209973", "l": "Tyrosine is diiodinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202233", "l": "Inactivation of Lck by Csk (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390930", "l": "5-HT2 receptor can bind serotonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46508", "l": "NADH + nitrobenzene + O2 = catechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213244", "l": "Loading of antigenic peptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68254", "l": "L-tryptophan(out) + Na(+)(out) => L-tryptophan(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29473", "l": "D-ribose + phosphate => D-ribose 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008770", "l": "[acyl-carrier-protein] phosphodiesterase activity", "d": ["Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618328", "l": "ATAT acetylates microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69202", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44023", "l": "H2O + NAD(+) + octadecanal <=> 2 H(+) + NADH + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140936", "l": "histone H2B deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58877", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047033", "l": "15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51979", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102950", "l": "indole-3-acetyl-valine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67748", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15533", "l": "(2R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114553", "l": "Activation of conventional Protein Kinase C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76386", "l": "CYP1A2 S-demethylates 6MMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0017116", "l": "single-stranded DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51372", "l": "(9Z)-hexadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043771", "l": "cytidine kinase activity", "d": ["Catalysis of the reaction: ATP + cytidine = ADP + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836702", "l": "PKR inhibitors bind PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209903", "l": "Noradrenaline is converted to adrenaline (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16175", "l": "(S)-norcoclaurine + H2O => (4-hydroxyphenyl)acetaldehyde + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18855", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => NAD(+) + tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67349", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA => apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34726", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O <=> 15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67436", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19138", "l": "17beta-estradiol + AH2 + O2 => 6beta-hydroxyestradiol-17beta + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0030366", "l": "molybdopterin synthase activity", "d": ["Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28583", "l": "ATP + dUDP => ADP + dUTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11712", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.7", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48407", "l": "apo-[aryl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63983", "l": "4-thiouridine + ATP <=> 4-thiouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378956", "l": "Luteinizing hormone is a heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211874", "l": "CYP2S1 4-hydroxylates atRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72624", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base => a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11059", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 <=> 4-aminophenol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57547", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56528", "l": "chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53293", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin => H(+) + N-carbamoyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67689", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O => 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45183", "l": "2 (E)-4-coumaroyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38260", "l": "(2R,3S)-beta-methylmalyl-CoA => glyoxylate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66278", "l": "H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP => tigogenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870269", "l": "Gastrin binds to CCK-B receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035870", "l": "dITP diphosphatase activity", "d": ["Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59148", "l": "ATP + CoA + marinolate C = AMP + diphosphate + marinoloyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73428", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] => H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39715", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38711", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71193", "l": "an L-alpha-amino acid(out) + L-kynurenine(in) => an L-alpha-amino acid(in) + L-kynurenine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65991", "l": "previtamin D3 <=> calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22021", "l": "ATP + H2O + molybdate(out) => ADP + H(+) + molybdate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749253", "l": "Formation of MCM2-7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160931", "l": "Disassembly of tight junctions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35313", "l": "3-oxoisoheptadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisoheptadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36021", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847880", "l": "CYTH proteins bind ARF1:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32882", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) <=> (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19009", "l": "a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate", "d": [], "t": []}, {"i": "EC:3.7.1.5", "l": "\"acylpyruvate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13974", "l": "diphosphate + H(+)(in) + H2O => 2 H(+)(out) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67694", "l": "ADP + H(+) + hexadecanedioate(out) + phosphate => ATP + H2O + hexadecanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050639", "l": "10-hydroxytaxane O-acetyltransferase activity", "d": ["Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626938", "l": "Beta-catenin binds SOX proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33197", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9834821", "l": "p-PRKRA dimer binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16819", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADPH => 6-phospho-D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009040", "l": "ureidoglycolate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28501", "l": "formaldehyde + mycothiol <=> S-(hydroxymethyl)mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46805", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine => a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41642", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021609", "l": "ESR-associated SRC autophosphorylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870469", "l": "RGGT geranylgeranylates RAB proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33151", "l": "(R)-dihydrolipoamide + acetyl-CoA = (R)-S(6)-acetyldihydrolipoamide + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28949", "l": "H(+)(in) + L-arabinose(out) => H(+)(out) + L-arabinose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57780", "l": "2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34120", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022186", "l": "SLC2A3 gene expression is stimulated by MECP2:CREB1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57086", "l": "a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60436", "l": "3-methylbutyl acetate + H2O = 3-methylbutanol + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.112", "l": "\"isoamyl acetate esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.62", "l": "\"5-deoxyribulose 1-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008808", "l": "cardiolipin synthase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59514", "l": "O-acetyl-L-seryl-[protein] + salicylate => acetylsalicylate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58489", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 => H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31839", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}, {"i": "EC:5.3.2.4", "l": "\"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034866", "l": "2,4,4-trimethylpentanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799330", "l": "The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58162", "l": "diphosphate + dolabradiene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12989", "l": "a dolichyl beta-D-mannosyl phosphate + H2O = a dolichyl phosphate + D-mannose + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.49", "l": "\"dolichylphosphate-mannose phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015591", "l": "D-ribose transmembrane transporter activity", "d": ["Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050204", "l": "oxalomalate lyase activity", "d": ["Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033485", "l": "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807565", "l": "GNLY is transferred to the phagosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629918", "l": "NEIL1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46076", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH = eicosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53757", "l": "allodeoxycholoyl-CoA + cholate => allodeoxycholate + choloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.260", "l": "\"rRNA small subunit pseudouridine methyltransferase Nep1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30525", "l": "GDP + H(+) + oxidized coenzyme F420-2 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683735", "l": "CHEK2 is recruited to DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017797", "l": "NOTCH3 binds YBX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0047661", "l": "amino-acid racemase activity", "d": ["Catalysis of the reaction: an L-amino acid = a D-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-844447", "l": "NLRP1 senses MDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32989", "l": "a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733969", "l": "Bile salts dissociate from FABP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57560", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.161", "l": "\"nepetalactol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018813", "l": "trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35814", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (-)-medicarpin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465924", "l": "OPN1LW binds 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74216", "l": "H2O + L-seryl-tRNA(Lys) => L-serine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.12", "l": "\"peptidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212380", "l": "Formation of TRAP coactivator complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45179", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69448", "l": "(2E,6E)-farnesyl diphosphate + H2O = delta-cadinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.11", "l": "\"pterin deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34836", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine => a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52906", "l": "ADP + coenzyme F430 + phosphate => 15,17(3)-seco-F430-17(3)-acid + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28246", "l": "(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.169", "l": "\"pantoate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694625", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48979", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + pyocyanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72411", "l": "inulobiose = alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.178", "l": "\"difructose-dianhydride-III synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21139", "l": "(R)-carnitine + acetyl-CoA <=> CoA + O-acetyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12440", "l": "H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.7", "l": "\"saccharopine dehydrogenase (NAD(+), L-lysine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196964", "l": "RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73800", "l": "SAICAR => AICAR + Fumarate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67243", "l": "(R)-S-adenosyl-L-methionine + H2O <=> adenosine + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033232", "l": "ABC-type D-methionine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54116", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + pseudolaratriene", "d": [], "t": []}, {"i": "EC:4.2.3.180", "l": "\"pseudolaratriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29527", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.258", "l": "\"dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252072", "l": "AZGP1 binds PIP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67107", "l": "2-oxoglutarate + fumigatonoid C + O2 <=> CO2 + H2O + novofumigatonin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22944", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.277", "l": "\"3beta-hydroxy-5beta-steroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.39", "l": "\"4-hydroxybenzoate polyprenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24050", "l": "alpha-D-glucose 1-phosphate + D-fructose => phosphate + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44660", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006323", "l": "Phospho-JAK2 phosphorylates EPOR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700156", "l": "Active ALK dimer binds IRS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72339", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) = catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30495", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37408", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210923", "l": "cya and lef bind to pagA(197-794):ANTXR1 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34574", "l": "C30 botryococcene + diphosphate + NADP(+) <=> H(+) + NADPH + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75895", "l": "holothin + marinoloyl-CoA C = CoA + thiomarinol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41164", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP => 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018494", "l": "carvone reductase activity", "d": ["Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047578", "l": "4-hydroxyglutamate transaminase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944225", "l": "Association of procollagen type XVII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693536", "l": "ATM phosphorylates MDC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38049", "l": "a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805276", "l": "CDK5 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12602", "l": "2-oxoglutarate + L-2-aminoadipate => 2-oxoadipate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807585", "l": "BPI binds LPS on the bacterial surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44068", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11493", "l": "H(+) + O-phospho-L-threonine => (R)-1-aminopropan-2-yl phosphate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218821", "l": "PDK1 phosphorylates PKC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24577", "l": "diphosphate + H2O => H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33668", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20938", "l": "3-methyl-2-oxobutanoate + H2O => 2,3-dihydroxy-3-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404144", "l": "Parenchymal atROL translocates to HSCs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43289", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168445", "l": "PTP1B binds the GH receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28885", "l": "H(+)(out) + L-threonine(out) => H(+)(in) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682388", "l": "Autophagosome maturation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23602", "l": "2-oxohexanoate + L-glutamate => 2-oxoglutarate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77455", "l": "formylthiophene + hydrogen cyanide = (2R)-2-hydroxy-2-(thiophen-2-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43895", "l": "[sulfur carrier]-H + L-cysteine <=> [sulfur carrier]-SH + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228943", "l": "Transcytosis and dissociation of botA:NTNHA:HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22545", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690340", "l": "Defective ABCC6 does not transport organic anion from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052579", "l": "(+)-pulegone reductase, (+)-isomenthone as substrate, activity", "d": ["Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42526", "l": "pseudouridine(1911/1915/1917) in 23S rRNA => uridine(1911/1915/1917) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050102", "l": "cellodextrin phosphorylase activity", "d": ["Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047434", "l": "indolepyruvate decarboxylase activity", "d": ["Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418456", "l": "cGMP is degraded by PDEs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156930", "l": "GTP-binding activates eEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372542", "l": "Loading of dopamine into synaptic veiscles (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32248", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11393", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10207", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] <=> formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37006", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749609", "l": "BCHE hydrolyzes ASA- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209376", "l": "SPN27A binds to and inhibits EA protease activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74324", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) => O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34062", "l": "agroclavine + NADP(+) <=> didehydroagroclavine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62396", "l": "(1S,2S)-pseudoephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49498", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39684", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953339", "l": "DNPH1 hydrolyses dGMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65483", "l": "2-methylbutanoyl-CoA + hexan-1-ol <=> CoA + hexyl 2-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654159", "l": "Activated FGFR2 binds PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141038", "l": "phosphatidylinositol 3-kinase activator activity", "d": ["Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28575", "l": "H(+)(in) + sulfate(in) => H(+)(out) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733960", "l": "Bile salts and acids dissociate from ALB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33021", "l": "(3S)-6-acetamido-3-aminohexanoate + CoA + H(+) => (3S)-3,6-diaminohexanoate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70787", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) = H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5225649", "l": "RBBP7 binds histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37289", "l": "ADP + H(+) + L-alanyl-L-leucine(in) + phosphate => ATP + H2O + L-alanyl-L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38219", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693608", "l": "Initial resection of double-strand break ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42408", "l": "(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.2.16", "l": "\"2-phosphoglycerate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016443", "l": "bidentate ribonuclease III activity", "d": ["Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23586", "l": "7,8-dihydrofolate + ADP + H(+) + phosphate => 7,8-dihydropteroate + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71166", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) <=> H(+)(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21393", "l": "2-phenylacetaldehyde + H2O + NAD(+) => 2-phenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796225", "l": "TEAD2,TEAD4:YAP1, TBXT, FOXH1, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68732", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110215", "l": "Cleavage of uracil by UNG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15498", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate => 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74924", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] => a (2E)-enoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63551", "l": "angiotensin-(1-9) + H2O <=> angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35919", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose = H(+) + kanamycin D + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731034", "l": "SARS-CoV-1 3a tetramer binds to CAV1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28478", "l": "galactarate(in) + H(+)(in) = galactarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58690", "l": "H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide => NADH + O2 + rifamycin SV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49574", "l": "coproporphyrin III + Fe(2+) => Fe-coproporphyrin III + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936475", "l": "Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706364", "l": "Internalization of ubiquitinated FLT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75694", "l": "2'-deoxyadenosine(in) <=> 2'-deoxyadenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62689", "l": "4 norrubrofusarin + O2 => 2 H2O + 2 ustilaginoidin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44409", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200406", "l": "CPT1A,B transfers PALM to CAR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389350", "l": "Activation of Cdc42 by pVav1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71454", "l": "bradykinin + H2O <=> bradykinin(1-7) + L-Phe-L-Arg", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0031634", "l": "replication fork barrier binding", "d": ["Binding to replication fork barriers, sites that inhibit the progress of replication forks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25673", "l": "sucrose + UDP-alpha-D-galactose <=> H(+) + loliose + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14476", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) <=> a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67891", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine <=> 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852362", "l": "GTSE1 binds CDKN1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15974", "l": "3'-phosphoadenylyl sulfate + estrone => adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371591", "l": "Trimerization of cytosolic HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18645", "l": "2 putrescine = NH4(+) + sym-homospermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44609", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60989", "l": "(E)-hex-2-en-1-ol + NAD(+) => (E)-hex-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036397", "l": "formate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: formate + a quinone = CO2 + a quinol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211164", "l": "AKT phosphorylates FOXO1A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57565", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71761", "l": "2-oxoglutarate(in) + heptanedioate(out) => 2-oxoglutarate(out) + heptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694427", "l": "MIA3 binds procollagen VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66234", "l": "H2O2 + IC-asc-DeltaC7-CoA => IC-asc-C7-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448702", "l": "Caspase-1 active tetramer formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73421", "l": "L-glutamine(in) => L-glutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429497", "l": "SLP-76 stimulates PLC gamma 2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005092", "l": "GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28663", "l": "H2O + melibiose = D-galactose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31408", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) => all-trans-4,4'-diapolycopene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634897", "l": "NPAS4 binds CDK5R1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45809", "l": "galactarate => (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863471", "l": "LDLR is bound by DAB2 and ARH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213246", "l": "Disassociation of CLIP from MHC II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50084", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445714", "l": "Aquaporin-3 passively transports water out of cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40389", "l": "1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50145", "l": "ethyl (9Z)-hexadecenoate + H2O => (9Z)-hexadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13685", "l": "lathosterol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74029", "l": "L-alanine(out) + L-threonine(in) => L-alanine(in) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871265", "l": "YAP1 binds TEAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58775", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645535", "l": "ALPK1 phosphorylates TIFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40829", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67005", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042958", "l": "maltodextrin transmembrane transporter activity", "d": ["Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781905", "l": "ZRANB1 binds APC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42505", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine => 6-acetamido-2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687875", "l": "Defective SFTPA2 does not translocate from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74692", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67495", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45821", "l": "mesaconate + succinyl-CoA => 2-methylfumaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876246", "l": "InlB-activated MET phosphorylates CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11023", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72553", "l": "glutarate(in) + urate(out) => glutarate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042169", "l": "SH2 domain binding", "d": ["Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051740", "l": "ethylene binding", "d": ["Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62805", "l": "2 7-demethylsiderin + NADPH + O2 => desertorin A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046917", "l": "triphosphoribosyl-dephospho-CoA synthase activity", "d": ["Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18378", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 3''-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112703", "l": "PTPN11 is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49872", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40618", "l": "H2O + tridecanoylglycerol <=> 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35839", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830435", "l": "Expression of PAX2 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754129", "l": "CDK6 inhibitors bind CDK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47312", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629918", "l": "NEIL1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48063", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102732", "l": "myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10055", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25109", "l": "ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52519", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650165", "l": "ASIC trimers bind H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42093", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15123", "l": "cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite => dithioerythritol + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43476", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5195402", "l": "CDK1 phosphorylates LPIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203070", "l": "Association of profilin with monomeric actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002401", "l": "Association of procollagen type XVIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64569", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24531", "l": "(R)-lactaldehyde + NAD(+) <=> H(+) + methylglyoxal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71342", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) <=> chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20014", "l": "carbamoyl phosphate + L-aspartate => H(+) + N-carbamoyl-L-aspartate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48819", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944233", "l": "Association of procollagen type XIX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57404", "l": "NAD(+) + narcotine hemiacetal = H(+) + NADH + noscapine", "d": [], "t": []}, {"i": "EC:1.1.1.415", "l": "\"noscapine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672019", "l": "Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64188", "l": "an N-(fatty acyl)-L-tyrosine + H2O = a fatty acid + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56873", "l": "(S)-N-acetyl-1-phenylethylamine + H2O => (S)-1-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37205", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015546", "l": "sulfathiazole transmembrane transporter activity", "d": ["Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007496", "l": "APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016531", "l": "copper chaperone activity", "d": ["Directly binding to and delivering copper ions to a target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42845", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH => 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004661", "l": "protein geranylgeranyltransferase activity", "d": ["Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714580", "l": "SLC6A3 binds DRIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76251", "l": "glutarate(in) = glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168849", "l": "tBID binds to inactive BAX protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30805", "l": "4-aminobutanoate + 2 H(+) + NADPH => 4-aminobutanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390912", "l": "HRH1 binds hist (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74645", "l": "CMP-N-acetyl-beta-neuraminate(out) + UMP(in) => CMP-N-acetyl-beta-neuraminate(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75242", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48346", "l": "a D-galactosylceramide + H(+) + UDP => an N-acyl-sphingoid base + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61977", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30742", "l": "1D-myo-inositol 3-phosphate + H2O <=> myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390425", "l": "FAR1 reduces PalmCoA to HXOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.176", "l": "\"propanoyl-CoA C-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28742", "l": "Cd(2+)(in) + H(+)(out) <=> Cd(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46189", "l": "an aliphatic nitrile + 2 H2O => a carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210290", "l": "Interaction of PECAM-1 and SHIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41227", "l": "(S)-4-hydroxymandelate + O2 = 4-hydroxyphenylglyoxylate + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.46", "l": "\"4-hydroxymandelate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34076", "l": "an acyl phosphate + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43875", "l": "3-oxochol-4-en-22-oate + ATP + CoA <=> 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36708", "l": "O-ureido-L-serine => O-ureido-D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035501", "l": "MH1 domain binding", "d": ["Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73915", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA = 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950456", "l": "IL12B dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24000", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004496", "l": "mevalonate kinase activity", "d": ["Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168136", "l": "Activated JNKs phosphorylate c-JUN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41847", "l": "(3R)-hydroxyoctanoyl-[ACP] <=> (2E)-octenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63420", "l": "2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.104", "l": "\"2-hydroxyethylphosphonate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63375", "l": "an acyl-CoA + L-cysteinyl-[protein] <=> an S-acyl-L-cysteinyl-[protein] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11570", "l": "5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75679", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27688", "l": "ADP + GTP => ATP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53099", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77064", "l": "1-cyclohexylethanamine + H2O + NADP(+) => 1-cyclohexylethanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990856", "l": "methionyl-initiator methionine tRNA binding", "d": ["Binding to methionine-initator methionine tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74964", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) => L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40826", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28888", "l": "H(+)(in) + L-serine(in) => H(+)(out) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187575", "l": "Ubiquitination of phospho-p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864381", "l": "TFAP2A,TFAP2C homodimers bind ESR1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76332", "l": "L-aspartate(in) + L-tyrosine(out) => L-aspartate(out) + L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873919", "l": "Phosphorylation of JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193647", "l": "IRAK is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45140", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": [], "t": []}, {"i": "EC:4.1.1.90", "l": "\"peptidyl-glutamate 4-carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604247", "l": "JAG1 binds NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25711", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624954", "l": "INPP5E translocates to the primary cilium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23806", "l": "N-acetyl-D-glucosamine 6-phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.145", "l": "\"galactan 1,3-beta-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354097", "l": "Activation of Talin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-990489", "l": "Kinesin-13 is a dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69787", "l": "(2-aminophenyl)succinate + succinyl-CoA = 3-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67358", "l": "(2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => (2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75744", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH => 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75632", "l": "H2O + plasmodiophorol B => plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694421", "l": "PP6 dephosphorylates SEC24 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57042", "l": "D-apiofuranose => aldehydo-D-apiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54228", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine = 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16364", "l": "2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.191", "l": "\"ginsenosidase type III\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62792", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B = 2 H2O + NADP(+) + nigerone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30784", "l": "D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047979", "l": "hexose oxidase activity", "d": ["Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202."], "t": []}, {"i": "EC:1.1.3.5", "l": "\"hexose oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854303", "l": "TBC1D11 binds RAB6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592371", "l": "Initial activation of proMMP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57720", "l": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.1.2.2", "l": "\"H(+)-transporting two-sector ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.-", "l": "\"alpha-Amino-acyl-peptide hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25002", "l": "(E)-phenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975865", "l": "IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76554", "l": "acetyl-CoA + D-aspartate <=> CoA + H(+) + N-acetyl-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006169", "l": "Factor H binds host cell surface markers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14079", "l": "beta-alanine + pyruvate => 3-oxopropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391372", "l": "GNRHR binds GNRH1,2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71503", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69068", "l": "RFC dissociates after sliding clamp formation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158849", "l": "Phenol can form a sulfate conjugate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54242", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19186", "l": "glyoxylate + H2O + propanoyl-CoA => 2-hydroxyglutarate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180725", "l": "Rev associates with B23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450348", "l": "Activated human JNKs migrate to nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823989", "l": "Expression of FOXA2 in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28776", "l": "dinoflagellate luciferin + O2 => H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44706", "l": "a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052895", "l": "N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity", "d": ["Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66714", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028583", "l": "Phosphorylation of YAP by LATS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28697", "l": "hydrogencarbonate(out) => hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050192", "l": "phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate + H2O = D-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68603", "l": "ORC5 binds ORC2:ORC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44496", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine = 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202604", "l": "Formation of a heteromeric BMP receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444433", "l": "Cho transports from the extracellular space to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17608", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine <=> ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663155", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NR1D1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19055", "l": "H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36782", "l": "2-oxoglutarate + GDP-alpha-D-perosamine <=> GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938815", "l": "RNF152 polyubiquitinates RRAGA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77129", "l": "1D-myo-inositol 2,3-bisphosphate + phosphate => 1D-myo-inositol 1,2,3-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57411", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008558", "l": "ABC-type guanine transporter activity", "d": ["Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052839", "l": "inositol diphosphate tetrakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49979", "l": "butanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428123", "l": "KDSR reduces 3-ketosphingoid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64353", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66117", "l": "2-oxobutanoate + L-glutamine => (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693783", "l": "NAALADases hydrolyse NAAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42802", "l": "all-trans-4,4'-diaponeurosporene + 3 FADH2 => 15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62682", "l": "H(+) + H2O + norrubrofusarin => naphtopyrone YWA1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754827", "l": "SARS-CoV-2 M binds TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252072", "l": "AZGP1 binds PIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37774", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39089", "l": "(2E)-decenedioyl-CoA + H2O2 => decanedioyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390011", "l": "HPO dimer binds to SAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789114", "l": "Hydroxyl radical reacts with the base and sugar moiety of DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47108", "l": "cholate + taurine = H2O + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67280", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.348834789597348", "identifiers": [{"i": "GO:0015175", "l": "neutral L-amino acid transmembrane transporter activity", "d": ["Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047195", "l": "diacylglycerol-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296326", "l": "HCAR1 binds LACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19149", "l": "L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57152", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.63", "l": "\"peptidyl-lysine (3S)-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047012", "l": "sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33146", "l": "galactitol(in) <=> galactitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089715", "l": "tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036478", "l": "L-dopa decarboxylase activator activity", "d": ["Interacts with and increases L-dopa decarboxylase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070815", "l": "peptidyl-lysine 5-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451311", "l": "Activation of Ca-permeable Kainate receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54075", "l": "(2E)-geranyl diphosphate <=> beta-thujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23377", "l": "L-threonate + NAD(+) => 3-dehydro-D-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164834", "l": "Enzyme-bound ATP is released (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804266", "l": "CHEK2 phosphorylates TTC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654651", "l": "Activated FGFR4 binds FRS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71505", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73267", "l": "H(+)(out) + L-methionine(in) = H(+)(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43147", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56890", "l": "UDP-4-dehydro-beta-L-rhamnose => UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071968", "l": "lipid A-core heptosyltransferase activity", "d": ["Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58123", "l": "ATP + L-seryl-[protein] <=> 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75074", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) <=> chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9652264", "l": "ERBB2 binds TKIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139893", "l": "Granzyme-B activates BID by cleavage (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.65", "l": "\"macrophage elastase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981355", "l": "RASA1 binds RAS:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202510", "l": "Activation of TAK1-TAB2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76928", "l": "3-aminopentane + H2O + NADP(+) => H(+) + NADPH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15531", "l": "2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+) => bis(2-ethylhexyl)phthalate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42760", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70785", "l": "H(+)(in) + L-aspartate(out) + L-glutamate(in) => H(+)(out) + L-aspartate(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050246", "l": "questin monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + questin = demethylsulochrin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070678", "l": "preprotein binding", "d": ["Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37262", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) <=> 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38064", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA => 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199404", "l": "CD40L binds CD40 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19851", "l": "ADP-D-ribose 2'-phosphate + H(+) + nicotinamide => H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49330", "l": "2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23158", "l": "(indol-3-yl)acetonitrile + H2O => (E)-(indol-3-yl)acetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21277", "l": "D-arabinitol + NADP(+) => D-xylulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53143", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015437", "l": "lipopolysaccharide floppase activity", "d": ["Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371527", "l": "HSF1 trimer translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.109", "l": "\"sphingomyelin deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37589", "l": "6-amino-2-oxohexanoate + L-glutamate => 2-oxoglutarate + D-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47471", "l": "(2E,4E)-tetradecadienoyl-CoA <=> (3E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187661", "l": "Ade-Rib binds AODORA2A and NTRK1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20718", "l": "NH4(+) + S-inosyl-L-homocysteine => H(+) + H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637800", "l": "Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38338", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> (20S)-ginsenoside Rg3 + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630044", "l": "Defective NTHL1 truncation mutants do not bind formamidopyrimidine (FapyA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400027", "l": "Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66500", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75328", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) => chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26199", "l": "ammeline + NH4(+) => H2O + melamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097063", "l": "cadmium ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12073", "l": "an (S)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23185", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798129", "l": "TP53 binds the CASP6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981093", "l": "IL12 bound to IL12R internalises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785898", "l": "IL4R binds JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833635", "l": "p-PKR dimer localizes to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44271", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.181", "l": "\"13-deoxydaunorubicin hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088439", "l": "FOXM1 binds CENPF promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76108", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 => (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60754", "l": "CoA + jasmolin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16341", "l": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.2", "l": "\"phosphomevalonate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983285", "l": "RAD51B binds RAD51C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76763", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,4-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018826", "l": "RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46498", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69053", "l": "RFC binding displaces Pol Alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798743", "l": "Exocytosis of secretory granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.9", "l": "\"(R)-2-hydroxyacyl-CoA dehydratase activating ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45082", "l": "ADP + dapdiamide E + H(+) + phosphate => 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928591", "l": "EPH:EFN tetramers oligomerise (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32271", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.85", "l": "\"3-isopropylmalate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14777", "l": "AMP + H(+) + H2O = IMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33625", "l": "AMP + diphosphate + dodecanoyl-CoA => ATP + CoA + dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35156", "l": "(S)-4,5-dihydroxypentane-2,3-dione => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13979", "l": "NH4(+) + pyruvate => D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50256", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044378", "l": "non-sequence-specific DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865182", "l": "OTUD7A hydrolyses K11diUb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14976", "l": "L-aspartate <=> D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53828", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788611", "l": "HYKK phosphorylates 5HLYS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828027", "l": "SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10267", "l": "alpha-D-glucose <=> beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52824", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759158", "l": "SQSTM1 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47767", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA <=> 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18633", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.5", "l": "\"carbamoyl-phosphate synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.48", "l": "\"heteroglycan alpha-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36531", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA = (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54160", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30694", "l": "H2O2 + methanol <=> formaldehyde + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382053", "l": "Translocation of PDGF from ER to Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43216", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51753", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41981", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604719", "l": "NOTCH4 gene transcription is inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63726", "l": "candesartan O-beta-D-glucuronoside + UDP => candesartan + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52247", "l": "4 H(+) + 4 Mn(2+) + O2 <=> 2 H2O + 4 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187697", "l": "TRKA recruits RIT and RIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029273", "l": "PI3K binds to p-6Y-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033142", "l": "nuclear progesterone receptor binding", "d": ["Binding to a nuclear progesterone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53710", "l": "(2E,4Z)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66040", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37621", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2529020", "l": "CK2 phosphorylates condensin I subunits (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18068", "l": "ATP + H2O + phosphonate(out) <=> ADP + H(+) + phosphate + phosphonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177920", "l": "Binding of GRB2 to GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75952", "l": "2-oxoglutarate + O2 + oripavine => CO2 + formaldehyde + neomorphinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72533", "l": "ADP + H(+) + methyl beta-D-galactoside(in) + phosphate => ATP + H2O + methyl beta-D-galactoside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15063", "l": "2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56731", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 <=> 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444433", "l": "Cho transports from the extracellular space to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71792", "l": "(R)-lactate(in) + H(+)(in) => (R)-lactate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602603", "l": "IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77326", "l": "glyoxylate + N(omega)-methyl-L-arginine <=> 5-(3-methylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909729", "l": "Activation of JAK kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165162", "l": "Phosphorylation of TSC2 by PKB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44308", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40330", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58754", "l": "1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18160", "l": "ATP + pyruvate <=> ADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429449", "l": "Syk activation leads to SLP-76 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398184", "l": "LARG activation by G alpha 12/13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33414", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O <=> (S)-malyl alpha-D-glucosaminide + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033405", "l": "UCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35646", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682983", "l": "ATM phosphorylates WHSC1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56864", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.281", "l": "\"coelimycin P1 polyketide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39595", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH = (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23039", "l": "2 inosine + O2 <=> 2 5'-dehydroinosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61329", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62403", "l": "(1R,2S)-ephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004577", "l": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865320", "l": "CBFB binds RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57852", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381668", "l": "cAMP activates EPAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70196", "l": "ATP + deamido-NAD(+) => ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202692", "l": "PIP3 binds to RhoA and activates it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66371", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA <=> 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57043", "l": "aldehydo-D-apiose <=> D-apiofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.775903698273282", "identifiers": [{"i": "GO:0043021", "l": "ribonucleoprotein complex binding", "d": ["Binding to a complex of RNA and protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21389", "l": "H2O + L-2-aminohexano-6-lactam => L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166284", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54577", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 => an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63126", "l": "ethanolamine + octadecanoate => H2O + N-octadecanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19542", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20539", "l": "(R)-4'-phosphopantetheine + apo-[ACP] + H(+) => H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54258", "l": "(3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66076", "l": "2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31238", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate <=> (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656947", "l": "OGG1beta translocates to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16642", "l": "a long-chain fatty acyl ethyl ester + H2O => a long-chain fatty acid + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52198", "l": "1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299318", "l": "Activation of TASK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30636", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60258", "l": "AH2 + formaldehyde + L-lysyl(4)-[histone H3] => A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30533", "l": "biotin + H2O + NAD(+) => biotinate sulfoxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62413", "l": "(E)-feruloyl-CoA + H2O => acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19463", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25582", "l": "beta-L-fucose => alpha-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29056", "l": "a ubiquinone + 2 H(+)(in) + H2 => a ubiquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005158", "l": "insulin receptor binding", "d": ["Binding to an insulin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876868", "l": "ECE1 cleaves EDN1(53-90) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67681", "l": "a long-chain fatty acyl-CoA + H2O => a long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724290", "l": "GNRHR2 binds GNRH1,2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33479", "l": "an acyl-CoA + lanosterol = CoA + lanosteryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55132", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.54", "l": "\"D-alanine--[D-alanyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614614", "l": "Cysteine is degraded to serine and H2S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43918", "l": "(25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691167", "l": "CUL1, SKP1, FBXL5 bind (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102738", "l": "(gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate = gibberellin A37 + carbon dioxide + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027598", "l": "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033814", "l": "propanoyl-CoA C-acyltransferase activity", "d": ["Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55661", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 => 2 A + echinenone + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102540", "l": "D-mannose 6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67135", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32227", "l": "(6R)-NADPHX = (6S)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044750", "l": "high-affinity nickel cation transmembrane transporter activity", "d": ["Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015170", "l": "propanediol transmembrane transporter activity", "d": ["Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656356", "l": "Defective SLC5A1 does not cotransport Glc and Na+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.42", "l": "\"D-threonine aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56405", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72595", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) = H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0004725", "l": "protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17756", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine <=> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373724", "l": "Nephrin binds NCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40316", "l": "glutaryl-CoA + O2 => (2E)-glutaconyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25682", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55530", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247960", "l": "Activation of p38 MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16945", "l": "(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:2.1.2.10", "l": "\"aminomethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867344", "l": "OMA1 hydrolyses OPA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32455", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51860", "l": "(2E)-geranyl diphosphate + umbelliferone = 8-geranylumbelliferone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51856", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) = (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71943", "l": "(S)-malate(out) + 3 Na(+)(out) = (S)-malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.1", "l": "\"alpha-amylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73612", "l": "CTP(out) + dCDP(in) => CTP(in) + dCDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047355", "l": "CDP-glycerol glycerophosphotransferase activity", "d": ["Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9633044", "l": "ESR binds STRN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17036", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> biphenyl-2,3-diol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45688", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) = N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51481", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50089", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37915", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173781", "l": "MARCO (SCARA2) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43736", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.266", "l": "\"23S rRNA (adenine(2030)-N(6))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799246", "l": "CHEK1 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685531", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22946", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5beta-pregnane-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416690", "l": "SEMA4A binds to PLXND1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47146", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68667", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38387", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034823", "l": "citronellyl-CoA ligase activity", "d": ["Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761120", "l": "BHLHE22 recruits PRDM8 to intron 1 of CDH11 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810076", "l": "DDO oxidizes D-Asp to OA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69672", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O => (2S)-naringenin + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334788", "l": "CUTC binds Cu+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35780", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => mutildienyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47419", "l": "an NDP-alpha-D-glucose + D-glucose <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69291", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> sulfate + sulforaphane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.114", "l": "\"equine arterivirus serine peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.42", "l": "\"cathepsin O\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417820", "l": "P2Y9 receptor can bind to LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48527", "l": "a ganglioside GP1c + H2O <=> a ganglioside GQ1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799466", "l": "TP53I3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706323", "l": "Active FLT3 binds to SLA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71304", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) => chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106625", "l": "Duplex siRNA is loaded into Argonaute (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75950", "l": "L-arginine + taurine <=> L-ornithine + taurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21813", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102248", "l": "diacylglycerol transacylase activity", "d": ["Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156699", "l": "Inactivation of Wee1 kinase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54409", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867613", "l": "PICALM binds R-SNAREs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61896", "l": "betaenone C = betaenone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45443", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.348834789597348", "identifiers": [{"i": "GO:0001727", "l": "lipid kinase activity", "d": ["Catalysis of the phosphorylation of a simple or complex lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77061", "l": "3-methylcyclopentanone + H(+) + NADPH + NH4(+) => 3-methylcyclopentanamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63239", "l": "ATP + streptomycin <=> 6-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20250", "l": "L-alanine => D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005251", "l": "delayed rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76804", "l": "2-aminopentan-1-ol + H2O + NAD(+) => 1-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102410", "l": "quercetin-4',3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) = quercetin 3,4'-O-diglucoside + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50966", "l": "NH4(+) + uridine(8) in tRNA => cytidine(8) in tRNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42668", "l": "L-rhamnofuranose + NADP(+) = H(+) + L-rhamnono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65461", "l": "acetyl-CoA + hexan-1-ol => CoA + hexyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602466", "l": "Activation of MT-MMPs by FURIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55584", "l": "an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.348", "l": "\"mRNA m(6)A methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215295", "l": "USP7 deubiquitinates MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66025", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54004", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19348", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008690", "l": "3-deoxy-manno-octulosonate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646468", "l": "mTORC1 binds RHEB:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25260", "l": "N-acetyl-D-glucosamine 6-phosphate <=> N-acetyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30905", "l": "H(+) + S-adenosyl-L-homocysteine + spheroidene => demethylspheroidene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62011", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38337", "l": "(20S)-ginsenoside Rg3 + 2 D-glucose => (20S)-ginsenoside Rb1 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71527", "l": "thymine(out) = thymine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39846", "l": "a 1,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694428", "l": "LMAN family proteins bind glycosylated cargo (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48722", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH => aurachin B + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31443", "l": "ATP + D-sedoheptulose 7-phosphate = ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813740", "l": "GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25199", "l": "5-amino-6-(D-ribitylamino)uracil + phosphate => 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57552", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.64", "l": "\"zeaxanthin 4-ketolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37776", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004020", "l": "adenylylsulfate kinase activity", "d": ["Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140905", "l": "haloperoxidase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + H2O2 = R-C-halogen + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68713", "l": "(2E,6E)-farnesyl diphosphate => (1S,2S,4R)-beta-elemene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71007", "l": "L-phenylalanine(out) + L-tryptophan(in) = L-phenylalanine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.26", "l": "\"HECT-type E3 ubiquitin transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801762", "l": "REG3A oligomerize to form a pore complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22094", "l": "15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617877", "l": "HOXA4 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731051", "l": "SARS-CoV-1 3b binds to RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52733", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate => adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54140", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941895", "l": "Formation of CDK4/6:CCND complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10109", "l": "(7S)-salutaridinol + NADP(+) => H(+) + NADPH + salutaridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74175", "l": "a secondary alkyl amine + H2O + NAD(+) = a ketone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47221", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013157", "l": "CDC42 binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12369", "l": "2-dehydro-D-gluconate + A => 2,5-didehydro-D-gluconate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74501", "l": "H2O + NADP(+) + penigequinolone A => H(+) + NADPH + yaequinolone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851096", "l": "NPM1-ALK- and JNK-dependent JUN phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47565", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853793", "l": "p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67119", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30531", "l": "biotinate sulfoxide + H(+) + NADH = biotin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73448", "l": "acetyl-CoA(in) + AMP(out) => acetyl-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018496", "l": "2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022881", "l": "protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021596", "l": "Membrane estrogen receptors bind SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.7", "l": "\"enzyme-thiol transhydrogenase (glutathione-disulfide)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70692", "l": "ornithine => putrescine + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62823", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430311", "l": "Rsu-1 interacts with Pinch1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63694", "l": "a beta-D-glucuronoside + H(+) + UDP => alcohol glucuronate acceptor + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050019", "l": "L-arabinitol 4-dehydrogenase activity", "d": ["Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159771", "l": "Furin cleaves pro-protein C to protein C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28194", "l": "(2S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.310", "l": "\"(S)-sulfolactate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71725", "l": "H(+)(in) + L-alanyl-L-leucyl-L-alanine(in) => H(+)(out) + L-alanyl-L-leucyl-L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034015", "l": "L-ribulose-5-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64258", "l": "CoA + H(+) + N-dodecanoylglycine => dodecanoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76792", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67223", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033961", "l": "cis-stilbene-oxide hydrolase activity", "d": ["Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17767", "l": "(2R)-2,3-bisphosphoglycerate + H(+) => (2R)-3-phospho-glyceroyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52164", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.77", "l": "\"phenylacetonitrile alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20345", "l": "[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.9", "l": "\"thioredoxin-disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29519", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.257", "l": "\"GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19039", "l": "an ethanediol => an epoxide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74404", "l": "2 (S)-lactate(in) + prostaglandin D2(out) => 2 (S)-lactate(out) + prostaglandin D2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50262", "l": "(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate => 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36385", "l": "AMP + H(+) + nebramycin 5' => carbamoyl adenylate + tobramycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106265", "l": "THPH synthase activity", "d": ["Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA."], "t": []}, {"i": "RHEA:64352", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45339", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine <=> [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937613", "l": "CRHBP binds CRH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.52", "l": "\"phosphoserine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373747", "l": "Phosphorylation of nephrin by FYN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607744", "l": "MALT1 binds BCL10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481010", "l": "Surface deployment of platelet dense granule membrane components (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56077", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76544", "l": "N-acetyl-S-(2-succino)-L-cysteine => fumarate + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22691", "l": "D-alanine + H2O + O2 <=> H2O2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.405", "l": "\"ribitol-5-phosphate 2-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23464", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.174", "l": "\"glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209081", "l": "Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047433", "l": "branched-chain-2-oxoacid decarboxylase activity", "d": ["Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H+ = 2-methylbutanal + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41782", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57132", "l": "L-ascorbate + O2 + tyramine = (R)-octopamine + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018664", "l": "benzoate 4-monooxygenase activity", "d": ["Catalysis of the reaction: benzoate + H+ + NADPH + O2 = 4-hydroxybenzoate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36331", "l": "ATP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202500", "l": "Activation of IKK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.151", "l": "\"xyloglucan-specific endo-beta-1,4-glucanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.179", "l": "\"gellan tetrasaccharide unsaturated glucuronosyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022911", "l": "CSPG is secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50092", "l": "a fatty acyl-CoA + taurine = an N-fatty acyl-taurine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66512", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987043", "l": "IL22RA1 binds JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112392", "l": "Resumption of elongation after recovery from pausing (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604731", "l": "Autocatalytic activation of MMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75240", "l": "TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481007", "l": "Exocytosis of platelet alpha granule contents (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43529", "l": "L-serine + NAD(+) => 2-aminomalonate semialdehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40335", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839098", "l": "Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166220", "l": "FA anion diffuses laterally to UCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39596", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445704", "l": "Calcium Binds Caldesmon (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033909", "l": "fucoidanase activity", "d": ["Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67225", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046175", "l": "Further sulfation on galactose residues produces KSPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832112", "l": "HNF1B binds the IRX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59079", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2895778", "l": "POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23824", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.28", "l": "\"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67520", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174058", "l": "Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870465", "l": "RGGT binds the RAB-binding subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989762", "l": "Expression of ABCB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53522", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43171", "l": "adenosine(34) in tRNA + H(+) + H2O <=> inosine(34) in tRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38477", "l": "H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine => L-histidine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is sequence specific\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497883", "l": "Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25737", "l": "2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29553", "l": "alpha-D-galactose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56042", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30556", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 => GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.57", "l": "\"aromatic-amino-acid transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.10", "l": "\"NADPH dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12596", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71296", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) => chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25901", "l": "D-arabino-hex-3-ulose 6-phosphate => beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534096", "l": "METAP1/2 demethylates GNAT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49139", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 <=> H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.47", "l": "\"acyl-lipid (9-3)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629679", "l": "PDE3A inhibitors bind PDE3A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38866", "l": "phosphate + sucrose 6(F)-phosphate <=> alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351948", "l": "Mitochondrial recruitment of Drp1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69127", "l": "Formation of the Flap Intermediate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835454", "l": "DNAJC3 binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29854", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine <=> 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140355", "l": "cargo receptor ligand activity", "d": ["The activity of a gene product that interacts with a cargo receptor and initiates endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341048", "l": "SUMOylation of RXRA with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36904", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56605", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69352", "l": "2 (E)-prop-1-en-1-SO-peroxol = H2O + thiosulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432897", "l": "ILK interacts with beta-1 integrin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430183", "l": "NCK binds PAK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817575", "l": "ERO1B oxidizes P4HB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021945", "l": "MECP2 binds GAMT gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12493", "l": "L-methionine => D-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73766", "l": "2 ATP + L-alanine + L-tryptophan <=> 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47685", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate => [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30563", "l": "dimethylallyl diphosphate + L-tryptophan = 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.80", "l": "\"7-dimethylallyltryptophan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50642", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61479", "l": "a sphingoid base + octadecanoyl-CoA <=> an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0008556", "l": "P-type potassium transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610327", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3B (GRIN3B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66220", "l": "asc-omegaC7-CoA + O2 = asc-omegaDeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37382", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65245", "l": "(2S)-hesperetin + UDP-alpha-D-glucose => (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050129", "l": "N-formylglutamate deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033857", "l": "diphosphoinositol-pentakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55418", "l": "biochanin A 7-O-beta-D-glucoside + H(+) + UDP => biochanin A + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052925", "l": "dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31613", "l": "H2O + rhodopin => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650710", "l": "Translation of PPP1R15A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59460", "l": "hexadecan-1-ol + NADP(+) = H(+) + hexadecanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22605", "l": "D-mannose => D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.4", "l": "\"chloroplast protein-transporting ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373717", "l": "DCC interacts with DIP13alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196017", "l": "Dynamin is recruited to the gap junction plaque (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607740", "l": "PKC-delta phosphorylates CARD9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849085", "l": "ARHGAP35 binds RHOA:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429157", "l": "ABCC4 accumulation of dense granule contents (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34444", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56388", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008892", "l": "guanine deaminase activity", "d": ["Catalysis of the reaction: guanine + H2O = xanthine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701488", "l": "Active ALK phosphorylates JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221061", "l": "TDG excises 5-carboxylcytosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48713", "l": "2 Fe(2+) + 2 H(+) + H2O2 => 2 Fe(3+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614605", "l": "Persulfide sulfur is dioxygenated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20411", "l": "D-glucose + FMN => alpha-D-glucose 1-phosphate + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56505", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53846", "l": "7-oxoglycolithocholate + H(+) + NADH => glycochenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.088320895280148", "identifiers": [{"i": "GO:0015145", "l": "monosaccharide transmembrane transporter activity", "d": ["Enables the transfer of a monosaccharide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41946", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19847", "l": "H(+) + isonocardicin A + S-methyl-5'-thioadenosine => nocardicin E + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55581", "l": "ATP + H2O + L-glutamine => AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65971", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41512", "l": "L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21776", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.28", "l": "\"3alpha,7alpha-dihydroxy-5beta-cholestanate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37986", "l": "gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67324", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine = (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11782", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41483", "l": "an acyl-CoA + episterol <=> an episterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49243", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) <=> L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55405", "l": "[phosphate](n) + UTP => [phosphate](n+1) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928619", "l": "PAK1 binds RAC1:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24363", "l": "2 H(+) + siroheme <=> Fe(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055077", "l": "gap junction hemi-channel activity", "d": ["A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247844", "l": "WNT ligands traffic to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59071", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine <=> deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818937", "l": "MEN1 binds MLL1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58865", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40318", "l": "glutaryl-CoA + O2 <=> (2E)-glutaconyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975115", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070412", "l": "R-SMAD binding", "d": ["Binding to a receptor-regulated SMAD signaling protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606602", "l": "ASAH1 hydrolyzes ceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014456", "l": "GDIs block activation of RHOG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59758", "l": "H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine => L-arginine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016871", "l": "cycloartenol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9022314", "l": "HIPK2 phosphorylates MECP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052775", "l": "endo-1,3-alpha-L-rhamnosidase activity", "d": ["Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75655", "l": "(9Z)-octadecenoate + O2 = (8R)-hydroperoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32633", "l": "erythromycin C + H2O + NADP(+) => erythromycin D + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76940", "l": "2-methylpropan-1-amine + H2O + NADP(+) => 2-methylpropanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32804", "l": "ATP + H2O + urea(out) => ADP + H(+) + phosphate + urea(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71739", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034536", "l": "2-hydroxy-8-methylchromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21608", "l": "isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.154", "l": "\"isoliquiritigenin 2'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40997", "l": "4-hydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627350", "l": "SMAC (DIABLO) binds XIAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019159", "l": "nicotinamide-nucleotide amidase activity", "d": ["Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029268", "l": "Phosphorylation and activation of PLCG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177942", "l": "EGFR binds EGF ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034812", "l": "9,10-dihydroxybenzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28050", "l": "H2O + NADP(+) = NAD(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54480", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51552", "l": "D-sorbitol + NADP(+) = H(+) + L-xylo-3-hexulose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416690", "l": "SEMA4A binds to PLXND1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008603", "l": "cAMP-dependent protein kinase regulator activity", "d": ["Modulation of the activity of the enzyme cAMP-dependent protein kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67697", "l": "H2O + hexadecanedioyl-CoA => CoA + H(+) + hexadecanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166817", "l": "Cleavage of C3 by C3 convertases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050560", "l": "aspartate-tRNA(Asn) ligase activity", "d": ["Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050291", "l": "sphingosine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64380", "l": "3 A + phytyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64606", "l": "diphosphate + uridylyl-L-seryl-[protein] => L-seryl-[protein] + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13397", "l": "6-oxohexanoate + H2O + NADP(+) = 2 H(+) + hexanedioate + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.63", "l": "\"6-oxohexanoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36323", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH = (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48663", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.109", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol => a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28573", "l": "ATP + L-serine <=> diphosphate + L-seryl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004549", "l": "tRNA-specific ribonuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641206", "l": "RSPOs bind LGRs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017855", "l": "NICD3 binds to TACC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70573", "l": "D-glucose(in) + Na(+)(in) => D-glucose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0050735", "l": "N-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58405", "l": "hexan-1-ol + NADP(+) => H(+) + hexanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004427", "l": "inorganic diphosphate phosphatase activity", "d": ["Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052759", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity", "d": ["Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35568", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine => (9Z,12Z)-octadecadienoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694541", "l": "SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38351", "l": "(R)-3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51189", "l": "nitric oxide + superoxide => peroxynitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72002", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40276", "l": "hexadecanedioyl-CoA + O2 => (2E)-hexadecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095889", "l": "MMACHC dealkylates RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73149", "l": "adenosine 3',5'-bisphosphate(in) + FAD(out) => adenosine 3',5'-bisphosphate(out) + FAD(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164943", "l": "Nef mediated activation of the T-cell receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13462", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047781", "l": "citrullinase activity", "d": ["Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68188", "l": "dodecanoyl-CoA + phytol = CoA + dodecanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803988", "l": "N2O3 enters bacteria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211924", "l": "CYP4B1 12-hydroxylates ARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12588", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.92", "l": "\"(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102064", "l": "gamma-curcumene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = gamma-curcumene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66215", "l": "asc-omegaC5-CoA + O2 <=> asc-omegaDeltaC5-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59023", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15855", "l": "17alpha-hydroxyprogesterone + H(+) + NADH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68697", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65401", "l": "butan-1-ol + butanoyl-CoA => butyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13354", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015211", "l": "purine nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11848", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.21.4.4", "l": "\"betaine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52327", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] <=> 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677051", "l": "Formation of the PCAF-ATAC complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418858", "l": "RhoGTPase GEF's recruited to DCC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42517", "l": "H2O + L-gulono-1,4-lactone => H(+) + L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380574", "l": "Dopamine synaptic vesicle docking and priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37173", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68749", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35522", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198813", "l": "GSTO dimers reduce DeHA to AscH- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10023", "l": "H2O + L-saccharopine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621606", "l": "CD209 binds ManLAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66816", "l": "2 Na(+)(in) + tetrahydroxoborate(in) = 2 Na(+)(out) + tetrahydroxoborate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183067", "l": "Localization of CBL:GRB2 to the membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75371", "l": "guanosine(in) = guanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74010", "l": "dimethylallyl diphosphate + H2O + yaequinolone E <=> [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14770", "l": "(S)-nicotine + A + H2O => (S)-6-hydroxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48608", "l": "A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811427", "l": "COPI vesicle uncoating at the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51978", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66029", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine => (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55174", "l": "2-hydroxyhexanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62495", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine <=> AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71345", "l": "chloride(in) + L-histidine(in) + 2 Na(+)(in) => chloride(out) + L-histidine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096488", "l": "RRP8 binds RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31692", "l": "(9Z,12Z)-octadecadienoate + O2 => (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48348", "l": "a uridine in RNA = a pseudouridine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0016174", "l": "NAD(P)H oxidase H2O2-forming activity", "d": ["Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203979", "l": "Coat Assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449077", "l": "Interleukin-16 is secreted (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60270", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404139", "l": "HSC cytosolic atROL translocates to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40106", "l": "H2O + propanoyl-CoA <=> CoA + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53007", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647978", "l": "pro-RAS proteins are farnesylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15753", "l": "GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.4", "l": "\"adenylosuccinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53625", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + tsukubadiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64349", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) => deacetylpyripyropene E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40691", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol = 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0009976", "l": "tocopherol cyclase activity", "d": ["Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.109", "l": "\"arginine N-succinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63206", "l": "H(+) + holo-[ACP] + octadecanoate => H2O + octadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004608", "l": "phosphatidylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0022821", "l": "solute:potassium antiporter activity", "d": ["Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047071", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102894", "l": "UDPG:cyclo-DOPA 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome = H+ + cyclo-dopa 5-O-glucoside + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64771", "l": "S-3-(hexan-1-ol)-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30313", "l": "formaldehyde + H2O + NAD(+) + xanthine => 7-methylxanthine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016621", "l": "cinnamoyl-CoA reductase activity", "d": ["Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24826", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011748", "l": "IL9R binds JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70795", "l": "H(+)(in) + L-lysine(out) = H(+)(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44161", "l": "1D-myo-inositol 6-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28537", "l": "dTTP + H2O <=> diphosphate + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833107", "l": "Association of NS1 (1C) with Cul5 and SCF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36801", "l": "a ribonucleoside 5'-phosphate + H(+) + phosphate => a ribonucleoside 5'-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112430", "l": "Formation of P-TEFb complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36915", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28621", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 <=> 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617874", "l": "HOXD4 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74278", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A <=> a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29636", "l": "D-maltopentaose + H2O => alpha-D-glucose + D-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35816", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696822", "l": "AKR1B15 reduces EST17b to E1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27434", "l": "2 glutathione amide + NAD(+) => glutathione amide disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.102", "l": "\"phenacrylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186785", "l": "PDGF-AA clevage by Furin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983150", "l": "Proteasomal cleavage of substrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15418", "l": "L-arogenate + NADP(+) => CO2 + L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626038", "l": "EEF1A1 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38070", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158849", "l": "Phenol can form a sulfate conjugate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47260", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917696", "l": "Cargo Sequestration (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20068", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71668", "l": "malonate(out) + succinate(in) => malonate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28914", "l": "H(+)(out) + L-lysine(out) <=> H(+)(in) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.71", "l": "\"adenosine-5'-diphospho-5'-[DNA] diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17318", "l": "chlorophyllide a + H(+) + phytyl diphosphate => chlorophyll a + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007926", "l": "ATRX binds DAXX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964496", "l": "STING binds TRIM32 or TRIM56  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55342", "l": "1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19679", "l": "(3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9'-cis-neoxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109339", "l": "Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29972", "l": "2'-deoxyinosine(in) + H(+)(in) => 2'-deoxyinosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77315", "l": "glyoxylate + N(omega),N('omega)-dimethyl-L-arginine = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40244", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37617", "l": "1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788623", "l": "p-Y-STATs translocate to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12664", "l": "(R)-carnitine + hexadecanoyl-CoA <=> CoA + O-hexadecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051267", "l": "CP2 mannose-ethanolamine phosphotransferase activity", "d": ["Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73765", "l": "2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate => 2 ATP + L-alanine + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23667", "l": "A + a (2R)-2-hydroxycarboxylate <=> a 2-oxocarboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203973", "l": "Vesicle budding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74256", "l": "H2O + L-homoseryl-tRNA(Ser) => H(+) + L-homoserine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24105", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA => 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13846", "l": "dihydroxyfumarate + H(+) => 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41994", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 17beta-hydroxy-5alpha-androstan-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71726", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) <=> H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944242", "l": "Association of procollagen type XXVII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73551", "l": "GDP(out) + UTP(in) = GDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665767", "l": "Activated FMNL3 binds G-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69444", "l": "(2E,6E)-farnesyl diphosphate = alpha-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15622", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928620", "l": "PAK1 autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755303", "l": "26S proteasome degrades HIFalpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39610", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH <=> (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21401", "l": "2-oxoglutarate + CoA + NADP(+) => CO2 + NADPH + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43615", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA <=> 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14023", "l": "20-hydroxyecdysone + A + H2O => AH2 + ecdysone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004316", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53657", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 => (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008412", "l": "CDK4 phosphorylates RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49950", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75554", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH <=> AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59555", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 <=> H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221061", "l": "TDG excises 5-carboxylcytosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390145", "l": "Phosphorylated HPO dimer phosphorylates SAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52476", "l": "estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190520", "l": "Association of Golgi  transport vesicles with microtubules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68208", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36794", "l": "H2O + N(omega)-hydroxy-L-arginine <=> hydroxyurea + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483087", "l": "PI is exchanged with PC by PITPNB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39377", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0015116", "l": "sulfate transmembrane transporter activity", "d": ["Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856157", "l": "LAG3 (CD233) binds MHC II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43921", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-555065", "l": "Formation of clathrin coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53801", "l": "lithocholoyl-CoA + ursodeoxycholate => lithocholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45620", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51833", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.116", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17918", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) => [Glu(-Cys)](n+1)-Gly + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008476", "l": "protein-tyrosine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114671", "l": "vWF binds to collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18349", "l": "ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": [], "t": []}, {"i": "EC:6.1.1.23", "l": "\"aspartate--tRNA(Asn) ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74742", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38005", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43158", "l": "H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine => guanosine(9) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31890", "l": "(S)-2,3-epoxysqualene <=> tirucalladienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68924", "l": "ATP + H(+) + hexanoate + NADPH = AMP + diphosphate + hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45371", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53033", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709831", "l": "HSP90 binds TBK1 and IRF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45830", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48454", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine => a ganglioside GA2 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70516", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400143", "l": "Fatty acid ligands activate PPARA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62940", "l": "H2O + N(4)-acetylcytosine = acetate + cytosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16135", "l": "3-aminopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1)-acetylspermine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050184", "l": "phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: An oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44528", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62681", "l": "naphtopyrone YWA1 => H(+) + H2O + norrubrofusarin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612277", "l": "SPARC gene transcription is stimulated by ERBB4s80 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44595", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42562", "l": "pseudouridine(27/28) in mitochondrial tRNA => uridine(27/28) in mitochondrial tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60157", "l": "ATP + D-galactose(out) + H2O => ADP + D-galactose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693575", "l": "DNA-PKcs autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59331", "l": "D-xylono-1,5-lactone + H2O <=> D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19508", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose <=> (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25288", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24944", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782943", "l": "UV-DDB ubiquitinates XPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74740", "l": "Binding of SHC1 to insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57028", "l": "FADH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0008252", "l": "nucleotidase activity", "d": ["Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate."], "t": []}, {"i": "RHEA:22140", "l": "a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12907", "l": "GDP-alpha-D-mannose + phosphate => alpha-D-mannose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444523", "l": "Formation of MSH1:PMS2 Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63347", "l": "ATP + L-amino acyl-L-threonyl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42763", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69906", "l": "cytidine(out) + 2 Na(+)(out) <=> cytidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162657", "l": "Inactivation of Myt1 kinase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112690", "l": "PTPN11 binds CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29339", "l": "(S)-malate(in) + 2 H(+)(in) = (S)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696997", "l": "USP24 deubiquitinates DDB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64531", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71045", "l": "L-alanine(out) + L-phenylalanine(in) => L-alanine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18424", "l": "acetyl-CoA + chloramphenicol <=> chloramphenicol 3-acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29544", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213239", "l": "Formation of MHC II alpha beta heterodimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29983", "l": "cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018640", "l": "dibenzothiophene monooxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32459", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.107", "l": "\"uroporphyrinogen-III C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938930", "l": "RUNX1 binds ELF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14613", "l": "ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)", "d": [], "t": []}, {"i": "EC:7.6.2.7", "l": "\"ABC-type taurine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373734", "l": "Nephrin interacts with Podocin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212614", "l": "Glutamine transport from astrocytes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68490", "l": "CO2 + H2O + tridecanal => (2R)-2-hydroperoxytetradecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39364", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64681", "l": "benzoyl-CoA + ethanol => CoA + ethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45594", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71978", "l": "glutathione(out) + 3 Na(+)(out) <=> glutathione(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18816", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15101", "l": "H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine", "d": [], "t": []}, {"i": "EC:4.1.1.20", "l": "\"diaminopimelate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65212", "l": "(2E)-dodecenoyl-CoA + H2O = (2E)-dodecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48116", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.322", "l": "\"type IV protein arginine methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59788", "l": "H2O + NAD(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682992", "l": "KDM4A,B bind H4K20Me2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008504", "l": "monoamine transmembrane transporter activity", "d": ["Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65748", "l": "2-oxoglutarate + dodecyl sulfate + O2 = CO2 + dodecanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420121", "l": "SFKs phosphorylate PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47292", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17453", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.13", "l": "\"phosphoribosylamine--glycine ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58277", "l": "6 ATP => cyclic hexaadenylate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17233", "l": "L-fucose = L-fuculose", "d": [], "t": []}, {"i": "EC:5.3.1.25", "l": "\"L-fucose isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73144", "l": "CoA(out) + FAD(in) => CoA(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851352", "l": "CCR8 binds CCL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68659", "l": "7-oxocholesterol + H(+) + NADPH <=> 7beta-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10467", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O <=> n acetate + chitosan", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16592", "l": "A + sucrose <=> 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50794", "l": "aldosterone + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176517", "l": "SULTs transfer (SO4)2- group to PREG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663293", "l": "RORA, EP300 bind SREBF1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36945", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163310", "l": "TFAM binds to mitochondrial promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27392", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> pyruvate + salicylaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61946", "l": "24-methylene cholesteryl beta-D-glucoside + H(+) + UDP => 24-methylenecholesterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60062", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038057", "l": "TNFSF11 binding", "d": ["Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9823816", "l": "OPTN binds CASP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030235", "l": "nitric-oxide synthase regulator activity", "d": ["Binds to and modulates the activity of nitric oxide synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54985", "l": "a ubiquinol => a ubiquinone + 2 e(-) + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001069", "l": "regulatory region RNA binding", "d": ["Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41316", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66378", "l": "D-erythrose + phosphate => D-erythrose 4-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32347", "l": "2 S-adenosyl-L-methionine + tricetin = 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.175", "l": "\"tricin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48653", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69185", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2545196", "l": "FN1 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16418", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34635", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + pentalenolactone D", "d": [], "t": []}, {"i": "EC:1.14.13.170", "l": "\"pentalenolactone D synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17775", "l": "AMP + diphosphate + L-cysteinyl-tRNA(Cys) => ATP + L-cysteine + tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20476", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090582", "l": "protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264435", "l": "Dissociation of the COP1-p53 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210430", "l": "Release of L-Glutamate at the synapse (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388596", "l": "Melanocortin receptors bind melanocortins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52264", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine = gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.340", "l": "\"3-aminomethylindole N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16205", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] = N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60618", "l": "ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate => N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12849", "l": "H2O + O-phospho-L-seryl-[myosin light chain] = L-seryl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69960", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33633", "l": "AMP + diphosphate + octanoyl-CoA => ATP + CoA + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41201", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210426", "l": "Glutamate synaptic vesicle docking and priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46617", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114558", "l": "Thrombin-activated PARs activate Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35884", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39631", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH = (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72801", "l": "L-arginine(in) + L-homoarginine(out) => L-arginine(out) + L-homoarginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68164", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047793", "l": "cycloeucalenol cycloisomerase activity", "d": ["Catalysis of the reaction: cycloeucalenol = obtusifoliol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034956", "l": "diphenyl ether 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62542", "l": "dihydroouabain + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55725", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675417", "l": "PEBP1 binds activated RAF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26009", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate <=> beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56822", "l": "A + cyclooctat-9-ene-5,7-diol + H2O => AH2 + cyclooctat-9-en-7-ol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37268", "l": "H2O + L-alanyl-L-aspartate => L-alanine + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75995", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047851", "l": "dicarboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69443", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) <=> 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9637589", "l": "MmpL7 transports PDIM from the cytosol to the cell wall (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391377", "l": "Luteinizing hormone receptor can bind LH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63370", "l": "ADP + H(+) + phosphate + spermine(in) => ATP + H2O + spermine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38890", "l": "H2O + N-hexanoyl-sphinganine <=> hexanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46206", "l": "androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.296", "l": "\"omega-hydroxyceramide transacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047164", "l": "isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62515", "l": "2-oxoglutarate + melatonin + O2 <=> 2-hydroxymelatonin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976801", "l": "Complement factor I complex formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696275", "l": "RND2 binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106240", "l": "labd-13Z-ene-9,15,16-triol synthase activity", "d": ["Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H+ + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:62192", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317332", "l": "PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853325", "l": "Plasma membrane FGFR1 fusions autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13937", "l": "4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": [], "t": []}, {"i": "EC:1.14.12.8", "l": "\"4-sulfobenzoate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043995", "l": "histone H4K5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691004", "l": "XPC binds RAD23 and CETN2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61766", "l": "H(+) + rebaudioside E + UDP => stevioside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47462", "l": "(3Z)-dodecenoyl-CoA + acetyl-CoA => 3-oxo-(5Z-tetradecenoyl)-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12000", "l": "formate + NADP(+) = CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.17.1.10", "l": "\"formate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.91", "l": "\"cellulose 1,4-beta-cellobiosidase (non-reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55721", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769345", "l": "Activated glucocorticoid receptor represses NPAS4 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694409", "l": "Nucleotide exchange on RAB1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029460", "l": "PAK1 phosphorylates LIMK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51422", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3S)-flavan-3-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018127", "l": "NAD(P)-serine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31489", "l": "H(+) + soyasaponin III + UDP => soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052672", "l": "CTP:geranylgeraniol kinase activity", "d": ["Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009485", "l": "IL34:CSF1 binds CSF1R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373705", "l": "Caspase cleavage of DCC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15755", "l": "GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate => GTP + IMP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60789", "l": "gibberellin A24 + H(+) + O2 => CO2 + gibberellin A9 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20901", "l": "H(+) + H2O + N-benzyloxycarbonylglycine => benzyl alcohol + CO2 + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709109", "l": "DHFR dimer binds DHFR inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.96", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42873", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445714", "l": "Aquaporin-3 passively transports water out of cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72261", "l": "3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine => L-dopa + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17768", "l": "(2R)-3-phospho-glyceroyl phosphate <=> (2R)-2,3-bisphosphoglycerate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0140135", "l": "mechanosensitive monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211950", "l": "CYP24A1 24-hydroxylates CTL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63430", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + H2O + levoglucosan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55794", "l": "1-hydroxy-2-butanone + H2O + NAD(+) => butan-2-one + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59313", "l": "D-galactose + O2 => D-galactono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45040", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015221", "l": "lipopolysaccharide transmembrane transporter activity", "d": ["Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33536", "l": "H2O + lanosteryl ester => a carboxylate + H(+) + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388829", "l": "SHP2 phosphatase binds CTLA-4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10595", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67863", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39669", "l": "a ketone + reduced coenzyme F420-(gamma-L-Glu)(n) => a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58361", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913451", "l": "IL3RB is phosphorylated on Ser-585 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0003958", "l": "NADPH-hemoprotein reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607733", "l": "BCL10 binds CARD9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72863", "l": "3',3',3'-cAAG + H2O = G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080054", "l": "low-affinity nitrate transmembrane transporter activity", "d": ["Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36143", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27938", "l": "(3R)-3-hydroxy-D-aspartate = glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71392", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.118", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050439", "l": "2-hydroxy-3-oxoadipate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35192", "l": "noranthrone + O2 => H2O + norsolorinic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42461", "l": "dibenzofuran + H(+) + NADH + O2 => biphenyl-2,2',3-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68579", "l": "ATP + H2O + xanthine(out) <=> ADP + H(+) + phosphate + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17880", "l": "a catechol + S-adenosyl-L-methionine <=> a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863472", "l": "DAB2 binds LRP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21314", "l": "CO2 + hydroquinone => 2,5-dihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030779", "l": "10-hydroxydihydrosanguinarine 10-O-methyltransferase activity", "d": ["Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74152", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015434", "l": "ABC-type cadmium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0015924", "l": "mannosyl-oligosaccharide mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17994", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine => ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14287", "l": "2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56746", "l": "(3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047067", "l": "hydrogen:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10528", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.100", "l": "\"dihydrosanguinarine 10-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65570", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36057", "l": "a 2,4-dihydroxypteridine + NH4(+) => a 2-amino-4-hydroxypteridine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102299", "l": "linolenate 9R-lipoxygenase activity", "d": ["Catalysis of the reaction: alpha-linolenate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69759", "l": "H2O + NAD(+) + nonanal = 2 H(+) + NADH + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097645", "l": "amylin binding", "d": ["Binding to amylin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37317", "l": "glycine + L-glutamine => glycyl-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22377", "l": "uridine(38/39/40) in tRNA => pseudouridine(38/39/40) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51628", "l": "formate + H(+) + UTP = CO2 + dUTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64122", "l": "a fatty acid + L-serine => an N-(fatty acyl)-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170012", "l": "histone H3K18 decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone H3 position 18] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone H3] + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75726", "l": "(9Z,12Z)-octadecadienoate + H2O <=> (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20390", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994038", "l": "IRF2 binds the promoters of Interferon alpha and beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56791", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin <=> cob(II)alamin-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68040", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21770", "l": "H(+) + methylamine + NADPH + pyruvate => H2O + N-methyl-L-alanine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832907", "l": "Expression of SOX1 in neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426157", "l": "SREBP1A,2 binds the MVK promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17858", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34936", "l": "2 ATP + H(+) => diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132283", "l": "Factor H binds to host cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29647", "l": "alpha-maltopentaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60843", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018467", "l": "formaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: formaldehyde + H2O + NAD+ = formate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67649", "l": "dATP + H2O => 2'-deoxyadenosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19713", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.15", "l": "\"arachidonate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42033", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68115", "l": "H2O + propanamide <=> NH4(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005544", "l": "calcium-dependent phospholipid binding", "d": ["Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102111", "l": "gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 = gibberellin A29 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29688", "l": "alpha-maltoheptaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14433", "l": "a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.72", "l": "\"CCA tRNA nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607747", "l": "TRAF6 binds MALT1 oligomers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25939", "l": "8-methylquinoline + A + H2O <=> 8-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39405", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59803", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21183", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol <=> D-glucose + indole-3-acetyl-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63816", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27457", "l": "3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070866", "l": "sterol-dependent protein binding", "d": ["Binding to a protein or protein complex in the presence of sterols."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25596", "l": "2-oxoglutarate + H(+) + isochorismate <=> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170120", "l": "Translocation of Cdc25B to the cytoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33857", "l": "a mannosylinositol-1-phosphophytoceramide + GDP + H(+) => an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654511", "l": "FGFRL1 dimer binds FGFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374723", "l": "Nociceptin receptor binds to nociceptin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22084", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246509", "l": "botC:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63331", "l": "2-(9Z-octadecenoyl)-glycerol + ATP <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56977", "l": "4-methylphenol + H2O + 2 oxidized [azurin] => 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50357", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 => 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64961", "l": "dTDP + H2O => dTMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68342", "l": "(R)-S-sulfopantetheine + phosphate => (R)-4'-phospho-S-sulfopantetheine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809309", "l": "MTMR6 binds MTMR9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48303", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester <=> glycerol + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168858", "l": "Palmitoylation of cysteine residues on HA in the cis-Golgi network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857686", "l": "FITM1, FITM2 bind TAGs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244424", "l": "botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42531", "l": "uridine(955/2504/2580) in 23S rRNA <=> pseudouridine(955/2504/2580) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21542", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => N-(5-phospho-beta-D-ribosyl)anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004528", "l": "phosphodiesterase I activity", "d": ["Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215295", "l": "USP7 deubiquitinates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874979", "l": "ACBD3 binds GOLGB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426355", "l": "NTN4 binds laminins with gamma-1, gamma-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63621", "l": "ATP + dodecanoate + holo-[ACP] => AMP + diphosphate + dodecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769177", "l": "NPAS4 stimulates PLK2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.804144929543213", "identifiers": [{"i": "GO:0008509", "l": "monoatomic anion transmembrane transporter activity", "d": ["Enables the transfer of a negatively charged ion from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-166214", "l": "FA anion flip-flops to the opposite surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11969", "l": "AH2 + kynurenate + O2 => 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58802", "l": "5'-pApG-3' + H(+) => 3',3'-cGAMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48225", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030755", "l": "quercetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69909", "l": "2 Na(+)(in) + uridine(in) => 2 Na(+)(out) + uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021406", "l": "NOTCH3 coactivator complex binds PBX1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852019", "l": "MET bound PI3K generates PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19320", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate <=> 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76389", "l": "1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+) => ATP + L-glutamate + N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159773", "l": "Furin cleaves pro-protein S to protein S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297333", "l": "Association of Acrosin Heavy and Light Chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782820", "l": "USP17 deubiquitinates SUDS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008336", "l": "gamma-butyrobetaine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140769", "l": "factor VII -> factor VIIa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050358", "l": "tropinone reductase activity", "d": ["Catalysis of the reaction: NADP+ + pseudotropine = H+ + NADPH + tropinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614605", "l": "Persulfide sulfur is dioxygenated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047279", "l": "sn-glycerol-3-phosphate 1-galactosyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35046", "l": "N-(4-aminobenzoyl)-L-glutamate(in) <=> N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332356", "l": "CAMK2 binds MAP3K7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63433", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15874", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693243", "l": "RHOD translocates to the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47038", "l": "pseudouridine in 5S rRNA => uridine in 5S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69866", "l": "a uridine in mRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45230", "l": "a 4-saturated (2E)-enoyl-CoA => a (3E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71428", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080067", "l": "4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45825", "l": "H(+) + L-serine => CO2 + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71555", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) = 5-aminoethyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50198", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12523", "l": "L-dopa <=> (E)-caffeate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016495", "l": "C-X3-C chemokine receptor activity", "d": ["Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940561", "l": "MMP7 cleaves OPTC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46476", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19019", "l": "ADP + H(+) + NADH + phosphate => (6S)-NADHX + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50127", "l": "NAD(+) + resolvin D1 <=> 8-oxoresolvin D1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51306", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26098", "l": "(4R)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39728", "l": "a sphingomyelin(in) => a sphingomyelin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37703", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59043", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51209", "l": "20-hydroxy-leukotriene B4 + NADP(+) => 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34313", "l": "2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite => 4-nitrocatechol + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42132", "l": "isonocardicin C = nocardicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53468", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070698", "l": "type I activin receptor binding", "d": ["Binding to a type I activin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42677", "l": "L-cysteine + L-histidine + O2 => H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35480", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953556", "l": "E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806732", "l": "GNLY binds the bacterial cell surface (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15806", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 => (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12144", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71783", "l": "MDH2 reduces OA to MAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35567", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine = (9Z,12Z)-octadecadienoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69281", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 3-hydroxypropyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38280", "l": "(3R)-citramalate + succinyl-CoA => (3R)-citramalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17909", "l": "(S)-lactate = acetaldehyde + formate", "d": [], "t": []}, {"i": "EC:4.1.2.36", "l": "\"lactate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102441", "l": "syringetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine = 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008660", "l": "1-aminocyclopropane-1-carboxylate deaminase activity", "d": ["Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804383", "l": "PRMT5 methylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56573", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose => a globoside Gb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983156", "l": "Polyubiquitination of substrate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25423", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O <=> 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73493", "l": "Co(2+)(in) + 2 hydrogencarbonate(in) => Co(2+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865482", "l": "KMT2A (MLL) binds RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485111", "l": "Collagen type III degradation by MMP10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71867", "l": "glycodeoxycholate(out) = glycodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72928", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682011", "l": "LC3 binds ATG7 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13775", "l": "(S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45766", "l": "2 H(+) + L-aspartate + NADH => H2O + L-aspartate 4-semialdehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045507", "l": "interleukin-25 receptor activity", "d": ["Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53285", "l": "NAD(+) + scyllo-inosose => 3-dehydro-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43410", "l": "beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP => sphinganine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9844860", "l": "ST3GAL5 transfers NeuNAc to ceramides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247849", "l": "WLS dissociates from retromer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50694", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955712", "l": "SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034904", "l": "5-chloro-2-oxopent-4-enoate hydratase activity", "d": ["Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30405", "l": "Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Fe(3+)(out) + L-ascorbate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421478", "l": "coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354173", "l": "Activation of Rap1 by cytosolic GEFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176452", "l": "Degradation of ubiquitinated SMAD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45057", "l": "deoxynogalonate + O2 => H(+) + H2O + nogalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3266557", "l": "Factor I cleaves iC3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654510", "l": "FGFRL1 binds SPRED1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45640", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20000", "l": "H2O + phosphoenolpyruvate <=> phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050504", "l": "mannosyl-3-phosphoglycerate synthase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36167", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.89", "l": "\"5'-deoxynucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73526", "l": "TTP(out) + UTP(in) <=> TTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21822", "l": "H(+) + L-methionine + S-adenosyl-L-homocysteine => L-homocysteine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848414", "l": "Activated PTK6 binds CDKN1B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67847", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49943", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29793", "l": "ADP + glutathione(in) + H(+) + phosphate => ATP + glutathione(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24252", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003711", "l": "transcription elongation factor activity", "d": ["A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17450", "l": "(2E)-geranyl diphosphate + flaviolin => 3-linalylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47885", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58848", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-hydroxygeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453346", "l": "PYGB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10263", "l": "ATP + H2O + Mg(2+)(out) <=> ADP + H(+) + Mg(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76386", "l": "CYP1A2 S-demethylates 6MMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75122", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) <=> all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3209165", "l": "ID1 sequesters ETS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682826", "l": "LGI1 binds ADAM11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858482", "l": "DVL is recruited to the receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45711", "l": "3-dehydrocarnitine + acetyl-CoA <=> 3-dehydrocarnityl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004801", "l": "transaldolase activity", "d": ["Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46126", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432129", "l": "FGR binds and phosphorylates LRP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140441", "l": "protein-cysteine S-arachidonoyltransferase activity", "d": ["Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13197", "l": "H(+) + sulfite + UDP-alpha-D-glucose = H2O + UDP-alpha-D-6-sulfoquinovose", "d": [], "t": []}, {"i": "EC:3.13.1.1", "l": "\"UDP-sulfoquinovose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75777", "l": "(10S)-hydroxy-(6Z,12Z)-octadecadienoate => (6Z,9Z,12Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168640", "l": "Ubiquitinated IkB is degraded (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60171", "l": "a fatty acid + ATP <=> a fatty acyl monophosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16676", "l": "3-phosphonopyruvate + H2O <=> H(+) + phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33415", "l": "bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.18", "l": "\"6-oxocamphor hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72433", "l": "(E)-caffeoyl-AMP + diphosphate => (E)-caffeate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29184", "l": "menaquinol-8 + 2 O2 => 2 H(+) + menaquinone-8 + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047301", "l": "valine-3-methyl-2-oxovalerate transaminase activity", "d": ["Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73118", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018659", "l": "4-hydroxybenzoate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52901", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide => 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73202", "l": "maleate(in) + sulfate(out) <=> maleate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667914", "l": "ALK binds ligand midkine (MDK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55291", "l": "tetradecan-1-ol + tetradecanoyl-CoA <=> CoA + tetradecanyl tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186773", "l": "PDGF dimer binds two receptors simultaneously (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237160", "l": "MTA is cleaved and phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37431", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823977", "l": "Expression of GATA6 in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53818", "l": "L-cysteine + succinate => hydrogen sulfide + O-succinyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63526", "l": "3-propylcatechol + H2O + NAD(+) => 2-propylphenol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905502", "l": "acetyl-CoA binding", "d": ["Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22232", "l": "H(+) + NADPH + presqualene diphosphate = diphosphate + NADP(+) + squalene", "d": [], "t": []}, {"i": "EC:1.3.1.96", "l": "\"Botryococcus squalene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63336", "l": "alpha-D-xylose = beta-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19623", "l": "a nucleoside 3'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419255", "l": "5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627078", "l": "XIAP binds CASP9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42821", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 => H2O + 2 NADP(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18125", "l": "A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62627", "l": "[glutaredoxin]-dithiol + a hydroperoxide <=> [glutaredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69116", "l": "Formation of Okazaki fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74819", "l": "glutathione(in) = glutathione(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12974", "l": "AMP + ATP => 2 ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27538", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700266", "l": "CFTR F508del binds CFTR correctors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139913", "l": "TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14586", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56532", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008928", "l": "mannose-1-phosphate guanylyltransferase (GDP) activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H+ = GDP-alpha-D-mannose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48495", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140908", "l": "histone H3K122 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672011", "l": "p-AMPK:AMP binds the ULK complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004999", "l": "vasoactive intestinal polypeptide receptor activity", "d": ["Combining with vasoactive intestinal polypeptide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22593", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate => (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323526", "l": "FRAT proteins bind GSK3beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59021", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53403", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052582", "l": "(+)-menthofuran synthase activity", "d": ["Catalysis of the reaction: (R)-pulegone + H+ + NADPH + O2 = (R)-menthofuran + 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50014", "l": "2-methylpropane-1,2-diol + H2O + NADP(+) => H(+) + NADPH + O2 + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73577", "l": "CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54506", "l": "beta-hexaprene + diphosphate => all-trans-hexaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19238", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide => 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68141", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH => (2R,5R)-hexanediol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61437", "l": "ADP + H2O => AMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757578", "l": "ALB binds PREDN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21380", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.24", "l": "\"phytanate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61565", "l": "a tetracycline + H(+) + NADPH + O2 => a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0003697", "l": "single-stranded DNA binding", "d": ["Binding to single-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61668", "l": "ATP + CoA + salicylate = 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.65", "l": "\"salicylate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11191", "l": "3-cyano-L-alanine + 2 H2O <=> L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67387", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52143", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390835", "l": "DRD1,5 bind DA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40322", "l": "O2 + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30143", "l": "H2O + octanoyl-CoA = CoA + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53648", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.171", "l": "\"(+)-corvol ether A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080122", "l": "AMP transmembrane transporter activity", "d": ["Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664867", "l": "NBR1 binds MAP1LC3B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50951", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46325", "l": "3-oxochol-4-en-22-oyl-CoA + A => 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847977", "l": "FRK phosphorylates PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190141", "l": "ALAD binds to Pb2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16392", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29399", "l": "H2O + ITP = diphosphate + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434058", "l": "LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73932", "l": "chloride + FADH2 + griseophenone C + O2 => FAD + griseophenone B + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51796", "l": "deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051538", "l": "3 iron, 4 sulfur cluster binding", "d": ["Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64562", "l": "butan-2-one + H(+) + NADH => butan-2-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61533", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-990489", "l": "Kinesin-13 is a dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20255", "l": "dimethylmaleate + H2O => (2R,3S)-2,3-dimethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33695", "l": "C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23095", "l": "H(+) + H2O + hydroxyatrazine <=> ethylamine + N-isopropylammelide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051509", "l": "tomatidine UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + tomatidine = UDP + O-glucosyl-tomatidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429449", "l": "Syk activation leads to SLP-76 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696271", "l": "RND1 binds effectors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13420", "l": "5,12-dihydroxanthommatin + NAD(+) <=> H(+) + NADH + xanthommatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990534", "l": "thermospermine oxidase activity", "d": ["Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016916", "l": "NOTCH3 coactivator complex binds the PTCRA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46885", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.193", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15382", "l": "O2 + quercetin => 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55023", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O <=> 5,6-diaminouracil + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0000295", "l": "adenine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28223", "l": "3-dehydro-L-gulonate + ATP => 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25568", "l": "ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}, {"i": "EC:2.7.1.173", "l": "\"nicotinate riboside kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69017", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77536", "l": "H2O + L-methionyl-tRNA(Leu) => H(+) + L-methionine + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050357", "l": "tropinesterase activity", "d": ["Catalysis of the reaction: atropine + H2O = H+ + tropate + tropine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41594", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57225", "l": "glyoxal + GTP => N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032867", "l": "L-arabinose:NADP reductase activity", "d": ["Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033964", "l": "glycosphingolipid deacylase activity", "d": ["Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427514", "l": "eNoSC deacetylates histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45234", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680242", "l": "Ligand-independent dimerization of KIT extracellular domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149433", "l": "Synthesis of VPU protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73718", "l": "UBF-1 Binds rDNA Promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34006", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 <=> 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69735", "l": "phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985594", "l": "MYO9B inactivates RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12190", "l": "CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] => 2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72680", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] => AMP + diphosphate + H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112435", "l": "Formation of Elongin BC complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102564", "l": "aurachin C epoxide hydrolase/isomerase activity", "d": ["Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H = aurachin B + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49098", "l": "3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine => H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112342", "l": "Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21088", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 = a flavonol + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.6", "l": "\"flavonol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18541", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine = dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.119", "l": "\"10-hydroxydihydrosanguinarine 10-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77492", "l": "3,3-dimethylbutan-2-one + hydrogen cyanide => (2S)-2-hydroxy-2-methyl-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408543", "l": "SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32523", "l": "nigerose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.279", "l": "\"nigerose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050037", "l": "L-xylose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: aldehydo-L-xylose + NADP+ = L-xylono-1,4-lactone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60925", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670413", "l": "JAK2 binds to p-KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201669", "l": "Beta-catenin translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64619", "l": "(E)-coniferol + acetyl-CoA <=> (E)-coniferyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68144", "l": "ethyl 3-oxobutanoate + H(+) + NADPH = ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186780", "l": "Degradation of Ub-SMAD7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60309", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080066", "l": "3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686174", "l": "Accessory proteins are recruited to the maturing virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014296", "l": "RAC2 GEFs activate RAC2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64622", "l": "(E)-sinapoyl actetate + CoA => (E)-sinapyl alcohol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888589", "l": "Release of GABA at the synapse (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34783", "l": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353044", "l": "2-phosphoglycerate <=> phosphoenolpyruvate + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433395", "l": "Dimerization of sSCF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56150", "l": "CoA + hexadecanoyl-sn-glycero-3-phosphocholine => hexadecanoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54888", "l": "(1S,2S)-OPC-8 + ATP + CoA = AMP + diphosphate + OPC8-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21007", "l": "(R)-pantolactone + A <=> 2-dehydropantolactone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73973", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71393", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374680", "l": "L1 trans-homophilic interaction (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66436", "l": "NADP(+) + pentan-3-one = H(+) + NADPH + pent-1-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72884", "l": "2 3-phenylpyruvate + 2 ATP => 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033520", "l": "TYSND1 cleaves TYSND1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52753", "l": "H2O + isomaltose => beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227778", "l": "MEKK1 binds TRAF6  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66107", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68844", "l": "(2Z,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40876", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) => (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64512", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395801", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32307", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4", "d": [], "t": []}, {"i": "EC:1.13.11.34", "l": "\"arachidonate 5-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688459", "l": "RIPK3 binds HSP90:CDC37 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36959", "l": "D-ribono-1,4-lactone + H(+) + NADH = D-ribose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70752", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005200", "l": "structural constituent of cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a cytoskeletal structure."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647978", "l": "pro-RAS proteins are farnesylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49921", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617595", "l": "SGTA binds mislocalized membrane protein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55107", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29955", "l": "H(+)(in) + thymidine(in) = H(+)(out) + thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59830", "l": "inosine + L-homocysteine => H2O + S-inosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23116", "l": "4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.27", "l": "\"4-hydroxybenzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677050", "l": "Formation of the GCN5-ATAC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75866", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640195", "l": "RRAGA,B hydrolyzes GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046876", "l": "3,4-didehydroretinal binding", "d": ["Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0003968", "l": "RNA-dependent RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44413", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18882", "l": "ATP + histamine + L-glutamate => ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323526", "l": "FRAT proteins bind GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004103", "l": "choline kinase activity", "d": ["Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59067", "l": "demethylluteothin + S-adenosyl-L-methionine <=> luteothin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73256", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine => (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997237", "l": "SH2B proteins bind JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23112", "l": "6-methylsalicylate + H(+) = 3-methylphenol + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.52", "l": "\"6-methylsalicylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015421", "l": "ABC-type oligopeptide transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12039", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.27", "l": "\"homospermidine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669911", "l": "Phosphorylation of juxtamembrane domain KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47741", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate => CO2 + demethylphylloquinone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371353", "l": "Soluble TNF-α binds TNFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32197", "l": "abieta-7,13-dien-18-al + H2O => abieta-7,13-dien-18,18-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170159", "l": "Translocation of Cdc25 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904483", "l": "synthetic cannabinoid binding", "d": ["Binding to synthetic cannabinoid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606163", "l": "p-SYK and LYN phosphorylate BTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848414", "l": "Activated PTK6 binds CDKN1B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44832", "l": "(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72810", "l": "L-histidine(out) <=> L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63938", "l": "3 a ubiquinol + protoporphyrin IX => 3 a ubiquinone + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72878", "l": "anthocyanin A7 + malonyl-CoA <=> anthocyanin A9 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007539", "l": "CHEK1 phosphorylates E2F6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948524", "l": "PTENP1 mRNA binds miR-19b RISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102728", "l": "campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity", "d": ["Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52996", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH = [eIF5A protein]-deoxyhypusine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863727", "l": "STON2 is neddylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45741", "l": "2-oxoglutarate + L-ectoine + O2 => 5-hydroxyectoine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21964", "l": "an acylcholine + H2O = a carboxylate + choline + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.8", "l": "\"cholinesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635667", "l": "esxG:esxH binds HGS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983421", "l": "Journey of cargo through Golgi complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69343", "l": "(E)-prop-1-en-1-SO-peroxol <=> (Z)-propanethial S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38298", "l": "(R)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73656", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38172", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA => 2-hydroxyhexadecyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23312", "l": "2 sucrose = 1(F)-beta-D-fructosylsucrose + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.99", "l": "\"sucrose:sucrose fructosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.15", "l": "\"desampylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29069", "l": "CO2 + menaquinol-8 => formate + H(+) + menaquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32926", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106322", "l": "S-(hydroxymethyl)glutathione dehydrogenase NAD activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.007505823603481", "identifiers": [{"i": "GO:0016647", "l": "oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.5.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204311", "l": "AOX1 oxidises PXL to PDXate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019705", "l": "protein-cysteine S-myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59736", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202437", "l": "Phosphorylation of CARMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.239", "l": "\"3alpha-(17beta)-hydroxysteroid dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43572", "l": "A + D-arginine + H2O = 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.99.6", "l": "\"D-arginine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67596", "l": "heptadecasphing-4-enine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41430", "l": "3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => L-tyrosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43361", "l": "an N-acylsphinganine + UDP-alpha-D-glucose => an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.-", "l": "\"With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72076", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine => ADP + H(+) + ophthalmate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158399", "l": "kallikrein binds SERPING1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68736", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] = ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30585", "l": "2-demethylmenaquinone-8 + H2O + trimethylamine => 2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019976", "l": "interleukin-2 binding", "d": ["Binding to interleukin-2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682967", "l": "WHSC1 binds DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41636", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050214", "l": "progesterone monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + progesterone = A + H2O + testosterone acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004474", "l": "malate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43076", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004000", "l": "adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20403", "l": "a substituted beta-amino acid => a beta-lactam + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45812", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.134", "l": "\"very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56756", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61600", "l": "[DsbD protein]-disulfide + [protein]-dithiol = [DsbB protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66869", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021068", "l": "PalmS-ESRs bind CAVs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31004", "l": "(S)-2,3-epoxysqualene => germanicol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32609", "l": "(6E)-8-hydroxygeranial + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191636", "l": "Phosphorylation of Cx43 by c-src (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203070", "l": "Association of profilin with monomeric actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695949", "l": "SPHK2 phosphorylates sphingoid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56758", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39397", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17505", "l": "H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine", "d": [], "t": []}, {"i": "EC:3.5.1.60", "l": "\"N-(long-chain-acyl)ethanolamine deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14895", "l": "(2R,4S)-2,4-diaminopentanoate => D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047034", "l": "15-hydroxyicosatetraenoate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63234", "l": "NAD(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093331", "l": "Ras:GTP binds p120-RasGAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73300", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) => (S)-malate(in) + H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098851", "l": "double-stranded miRNA binding", "d": ["Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72691", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692867", "l": "HRH3 binds pitosilant (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989752", "l": "Expression of TXNRD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72176", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047180", "l": "salutaridinol 7-O-acetyltransferase activity", "d": ["Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31571", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 = CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.113", "l": "\"(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009007", "l": "site-specific DNA-methyltransferase (adenine-specific) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619756", "l": "NR1H2 binds ABCA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35852", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20795", "l": "ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65630", "l": "CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine => sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21633", "l": "2 catechol + O2 => 2 1,2-benzoquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20447", "l": "L-aspartate + prephenate => L-arogenate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.51", "l": "\"HycI peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25316", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68811", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O <=> alpha-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21304", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72015", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine = 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68734", "l": "H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase] => ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30239", "l": "n a quinone + n H(+) + n hydrogen sulfide = n a quinol + n sulfur", "d": [], "t": []}, {"i": "EC:1.8.5.4", "l": "\"bacterial sulfide:quinone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31032", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74374", "l": "a carboxylate(out) + nicotinate(in) <=> a carboxylate(in) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659922", "l": "Defective SI does not hydrolyze Mal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34754", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine <=> ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633414", "l": "TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22260", "l": "H2O + triacetate lactone = H(+) + triacetate", "d": [], "t": []}, {"i": "EC:3.1.1.38", "l": "\"triacetate-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64208", "l": "an N-(fatty acyl)-L-glutamine + H2O = a fatty acid + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015611", "l": "ABC-type D-ribose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70866", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) <=> L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380586", "l": "loading of Serotonin in synaptic vesicles (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031473", "l": "myosin III binding", "d": ["Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70847", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) = L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49834", "l": "a fatty acid + 2 H(+) + NADH => a fatty aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32643", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine = 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.17.2.2", "l": "\"lupanine 17-hydroxylase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24908", "l": "(E)-4-coumarate + NH4(+) => L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784735", "l": "PCSK9:LDLR bind to Clathrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157926", "l": "NICD1 traffics to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30908", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) => 2-methylbutanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47132", "l": "11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799466", "l": "TP53I3 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821366", "l": "AKAP8L binds MLL2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75695", "l": "2'-deoxycytidine(in) = 2'-deoxycytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21793", "l": "NADP(+) + propan-2-ol => acetone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848395", "l": "IL18:IL18R1 binds IL18RAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64676", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol = butyl 3-(methylsulfanyl)propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612085", "l": "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49530", "l": "(ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+) => (ethylene terephthalate)(n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043724", "l": "2-keto-3-deoxygalactonate aldolase activity", "d": ["Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0045159", "l": "myosin II binding", "d": ["Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:0070851", "l": "growth factor receptor binding", "d": ["Binding to a growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060228", "l": "phosphatidylcholine-sterol O-acyltransferase activator activity", "d": ["Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428123", "l": "KDSR reduces 3-ketosphingoid (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42362", "l": "keto-D-fructose => D-allulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71767", "l": "2 Fe(2+) + H(+) + NADP(+) = 2 Fe(3+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49081", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 => dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20072", "l": "(Z)-phenylacetaldehyde oxime <=> H2O + phenylacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34786", "l": "a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047927", "l": "gibberellin-44 dioxygenase activity", "d": ["Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33712", "l": "4-sulfomuconolactone + H2O => 2 H(+) + maleylacetate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40065", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633441", "l": "TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632671", "l": "CSNK1A1 binds SMO dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050282", "l": "serine 2-dehydrogenase activity", "d": ["Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43773", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56514", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944257", "l": "Association of procollagen type XXIV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.49", "l": "\"amine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17618", "l": "leukotriene C4 => glutathione + leukotriene A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47678", "l": "ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate => ATP + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018794", "l": "RHOV binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64770", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol => S-3-(hexan-1-ol)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21034", "l": "acceptor beta-D-glucuronoside + H(+) + UDP => glucuronate acceptor + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58894", "l": "adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9 => 3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939066", "l": "PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60103", "l": "cyanidin + UDP-alpha-D-glucose <=> cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41953", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52626", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022911", "l": "CSPG is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805276", "l": "CDK5 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69754", "l": "benzylmalonyl-CoA + H(+) + O2 <=> (E)-cinnamoyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54880", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54104", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11436", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": [], "t": []}, {"i": "EC:7.1.1.9", "l": "\"cytochrome-c oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41118", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112150", "l": "RNA Polymerase III Promoter Opening at Type 2 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61374", "l": "4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33661", "l": "H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+) => H(+) + N-tetracosanoylsphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45836", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30254", "l": "2 a ubiquinol + n H(+)(in) + O2 <=> 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018542", "l": "NOTCH3 coactivator complex binds DLGAP5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627107", "l": "XIAP binds CASP7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36477", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632668", "l": "SMO translocates to the cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21864", "l": "an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65217", "l": "3-oxododecanoyl-CoA + H2O => 3-oxododecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32870", "l": "myo-inositol(out) <=> myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024586", "l": "AT-RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089710", "l": "endocytic targeting sequence binding", "d": ["Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62275", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14436", "l": "a tRNA precursor + ATP + 2 CTP <=> a tRNA with a 3' CCA end + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47097", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27638", "l": "phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12045", "l": "a triacylglycerol + H2O => a diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37208", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654425", "l": "Activated FGFR4 binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963851", "l": "VD3 dissociates from GC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13689", "l": "diphosphate + glycerol = glycerol 1-phosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.79", "l": "\"diphosphate--glycerol phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53179", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67538", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine => (9Z,12Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58242", "l": "ADP-D-ribose + L-cysteinyl-[protein] => H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71941", "l": "2-oxoglutarate(in) + 3 Na(+)(in) => 2-oxoglutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840795", "l": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65770", "l": "a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61341", "l": "(S)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11547", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31115", "l": "ATP + biotin + H(+) = biotinyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11413", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP => (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72225", "l": "4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in) => 4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110011", "l": "Binding of Grb10 to the insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48279", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706298", "l": "Active FLT3 binds to CSK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003917", "l": "DNA topoisomerase type I (single strand cut, ATP-independent) activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683774", "l": "p-T68-CHEK2 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41294", "l": "H2O + N-dodecanoylsphing-4-enine <=> dodecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.118", "l": "\"kallikrein 8\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54281", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806974", "l": "MET dimers autophosphorylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30901", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP => bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10492", "l": "H2O + phosphocholine = choline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24665", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62162", "l": "N-(9Z-octadecenoyl) ethanolamine + phosphate => H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070746", "l": "interleukin-35 binding", "d": ["Binding to interleukin-35."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57098", "l": "1-deoxy-D-xylulose 5-phosphate + A + methanethiol => AH2 + S-methyl-1-thio-D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41905", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863494", "l": "ASICs bind STOML3, (STOM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25534", "l": "diphosphate + ent-cassa-12,15-diene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672957", "l": "PP2A dephosphorylates KSR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375384", "l": "Bombesin-like receptors bind bombesin homologues (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76480", "l": "hexadecane-1,16-diol + O2 => H2O2 + hydroxyhexadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114683", "l": "Phosphorylation of Platelet Sec-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008220", "l": "Expression of globin genes under control of the beta globin control region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19400", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29495", "l": "(2E,6E)-farnesyl diphosphate + H2O = beta-eudesmol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.68", "l": "\"beta-eudesmol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203700", "l": "eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11587", "l": "L-ornithine <=> D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139920", "l": "Translocation of tBID to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43256", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56017", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641206", "l": "RSPOs bind LGRs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27804", "l": "all-trans-decaprenyl diphosphate + 7 diphosphate => (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20767", "l": "(S)-methylmalonyl-CoA + pyruvate <=> oxaloacetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22455", "l": "[phosphate](n+1) + n H2O <=> n H(+) + (n+1) phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47288", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75604", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => plasmodiophorol A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002460", "l": "P4HB binds Collagen chains (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761474", "l": "AMOT-2 binds CDH11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.159", "l": "\"dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031750", "l": "D3 dopamine receptor binding", "d": ["Binding to a D3 dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51719", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296301", "l": "CCRL2 binds CCL19 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5227009", "l": "ABCF1 binds EIF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44527", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193703", "l": "IKKbeta is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69053", "l": "RFC binding displaces Pol Alpha (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61083", "l": "(+)-minovincinine + acetyl-CoA <=> (+)-echitovenine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218812", "l": "FYN phosphorylates PAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001093", "l": "TFIIB-class transcription factor binding", "d": ["Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358789", "l": "Self-ubiquitination of RNF41 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72364", "l": "chloride(out) + hydrogencarbonate(in) => chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41412", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23616", "l": "1,2-dihydro-alpha-santonin + NADP(+) = alpha-santonin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034948", "l": "2,6-dihydroxypseudooxynicotine hydrolase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17316", "l": "ATP + L-histidine + tRNA(His) <=> AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66419", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53788", "l": "allodeoxycholoyl-CoA + beta-muricholate = allodeoxycholate + beta-muricholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782138", "l": "ERCC5 and RPA bind TC-NER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22296", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70051", "l": "2-oxoadipate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65613", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25174", "l": "H2O + N(omega)-methyl-L-arginine => L-citrulline + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975880", "l": "MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62860", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA = 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982017", "l": "Active G alpha (q) binds RGS proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67468", "l": "H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76979", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64404", "l": "carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032033", "l": "myosin II light chain binding", "d": ["Binding to a light chain of a myosin II complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61301", "l": "5-deoxy-D-ribulose 1-phosphate => acetaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34587", "l": "2-oxoglutarate + O2 + pentalenolactone E = CO2 + pentalenolactone F + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794347", "l": "Homer1,2,3 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12866", "l": "1-methyladenosine + H2O => 1-methyladenine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32358", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + 2 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62771", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821366", "l": "AKAP8L binds MLL2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189069", "l": "sucrose + H2O => glucose + fructose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981657", "l": "IL34 dimer binds PTPRZ1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659879", "l": "Defective SI does not hydrolyze iMal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15581", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA = biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.115", "l": "\"isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102285", "l": "1-deoxy-11-oxopentalenate oxygenase activity", "d": ["Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34883", "l": "ATP + H2O + selenate(out) = ADP + H(+) + phosphate + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799329", "l": "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28951", "l": "H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63261", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH => 4-pyridoxate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785594", "l": "FANCD2 binds FANCI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60679", "l": "(S)-(-)-citronellol + NAD(+) <=> (S)-(-)-citronellal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37410", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66479", "l": "gypsogenate + UDP-alpha-D-glucose <=> gypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656891", "l": "OPN1SW binds 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24513", "l": "L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52663", "l": "an L-alpha-amino acid + ATP + holo-[ACP] <=> AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0016886", "l": "ligase activity, forming phosphoric ester bonds", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.5.-.-", "l": "\"Forming phosphoric ester bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34837", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391158", "l": "SIRP alpha binds CD47 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72131", "l": "agmatine(out) = agmatine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45463", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45772", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate = [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.319", "l": "\"beta-1,4-mannooligosaccharide phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50938", "l": "acetoacetyl-CoA + L-glutamate => (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59262", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295599", "l": "SPRY2 translocates to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56548", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28051", "l": "H2O + NADP(+) => NAD(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57983", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside F1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050456", "l": "cystine reductase activity", "d": ["Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034026", "l": "L-amino-acid alpha-ligase activity", "d": ["Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73310", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) <=> H(+)(out) + L-aspartate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16496", "l": "glycerol 1,2-cyclic phosphate + H2O <=> glycerol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29429", "l": "(R)-carnitine(in) + 4-(trimethylamino)butanoate(out) => (R)-carnitine(out) + 4-(trimethylamino)butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170149", "l": "Translocation of active Cdc25C to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.1", "l": "\"exodeoxyribonuclease I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507875", "l": "Aquaporins passively transport urea into cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44355", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75802", "l": "Na(+)(out) + pyruvate(out) <=> Na(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372564", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17188", "l": "IMP + NADP(+) + NH4(+) <=> GMP + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38789", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58977", "l": "H2O + malonaldehyde + O2 => 3-oxopropanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034914", "l": "trinitrophenol hydride denitratase activity", "d": ["Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.183", "l": "\"glycoprotein-mannosyl O(6)-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26405", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) = H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665998", "l": "MKL1 binds SRF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201637", "l": "Caspase-mediated cleavage of plectin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45799", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40401", "l": "H2O2 + NADP(+) => 1,2-dihydro-beta-NADP + H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178189", "l": "SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851988", "l": "BTN2A2 binds T cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59532", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198669", "l": "p38MAPK phosphorylates MSK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57276", "l": "a 2'-deoxyguanosine in DNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73872", "l": "(R)-noradrenaline(out) => (R)-noradrenaline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788623", "l": "p-Y-STATs translocate to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63183", "l": "NADPH + 2 O2 <=> H(+) + NADP(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39361", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421485", "l": "Translocation of coproporphyrinogen III from the cytosol to the mitochondrial intermembrane space (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51090", "l": "13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129362", "l": "Fibrillin microfibril assembly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64808", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine = CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41783", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9017491", "l": "RHOJ GEFs activate RHOJ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18258", "l": "coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52026", "l": "18S-resolvin E2 + A + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39634", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH <=> (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102936", "l": "gypsogenate-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.3", "l": "\"metridin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112429", "l": "Formation of FACT complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41376", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008766", "l": "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity", "d": ["Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69959", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851979", "l": "BTNL9 binds immune cell surfaces (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63295", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23578", "l": "berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68021", "l": "(2E)-geranyl phosphate + H2O => (2E)-geraniol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71659", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] = a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.11", "l": "\"glucoside 3-dehydrogenase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176298", "l": "Activation of claspin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29508", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-gurjunene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509838", "l": "ITPA hydrolyses dITP to dIMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36370", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O <=> 2-hydroxyglutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24012", "l": "gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749215", "l": "MCM8 binds CDC6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427337", "l": "MBD2 binds methylcytosine in chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70201", "l": "5,6-dihydroxyindole => dopaminechrome", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042615", "l": "CD154 receptor binding", "d": ["Binding to CD154, a receptor found on the surface of some activated lymphocytes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50952", "l": "7-chloro-L-tryptophan + AH2 + O2 = A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24190", "l": "1,2-dihydroxydibenzothiophene + H(+) + NADH => cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45714", "l": "acetyl-CoA + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnityl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34164", "l": "hydroquinone + O2 => (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140769", "l": "ACP-dependent peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-[ACP] = H+ + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:70611", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate = 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.96", "l": "\"5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102613", "l": "trimethyluric acid monooxygenase activity", "d": ["Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ = 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388814", "l": "Grb2 binds CD28 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54042", "l": "(3E,7E)-dolathalia-3,7,11-triene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004876", "l": "complement component C3a receptor activity", "d": ["Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168301", "l": "Elongation, Polyadenylation and Termination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72050", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline <=> AH2 + fusahexin + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17966", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) => (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870461", "l": "RABGGTA and RABGGTB bind (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000254", "l": "C-4 methylsterol oxidase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198621", "l": "AKT phosphorylates caspase-9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61403", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16146", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43229", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29614", "l": "H2O + NADP(+) + nitrous oxide <=> H(+) + NADPH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32872", "l": "a 2-acylglycerol + H2O => a carboxylate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011143", "l": "ROBO3.1 expression is stimulated by LHX2,(LHX9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803233", "l": "Dissociation of oncogenic RAS:RAF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018650", "l": "styrene monooxygenase activity", "d": ["Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71019", "l": "L-phenylalanine(out) + L-valine(in) = L-phenylalanine(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050304", "l": "nitrous-oxide reductase activity", "d": ["Catalysis of the reaction: H2O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48145", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine => ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15508", "l": "(S)-2-hydroxymethylglutarate + NAD(+) <=> 2-formylglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.135", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47373", "l": "a quinone + D-glucose => a quinol + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46446", "l": "(10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (11Z)-hexadecenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032131", "l": "alkylated DNA binding", "d": ["Binding to an alkylated residue in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940100", "l": "CDK1 phosphorylates VCPIP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44572", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) = 2-all-trans-heptaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68828", "l": "borneol + NAD(+) = camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49922", "l": "(R)-carnitine(in) + O-octanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-octanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37655", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033752", "l": "acetylacetone-cleaving enzyme activity", "d": ["Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408555", "l": "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166214", "l": "FA anion flip-flops to the opposite surface (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434836", "l": "Syk/Lck phosphorylate LAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40080", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72544", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) => 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49536", "l": "2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56861", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate => a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22342", "l": "3-hydroxybenzaldehyde + H(+) + NADPH => 3-hydroxybenzyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45578", "l": "(2S)-methylsuccinyl-CoA => (2R)-ethylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68440", "l": "beta-cryptoxanthin + O2 = (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432825", "l": "HMGB1 binds TLR4:LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24766", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39956", "l": "(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683964", "l": "ATM phosphorylates EYA1-4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193964", "l": "CYP21A2 21-hydroxylates PROG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17675", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047174", "l": "putrescine N-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39199", "l": "(3R)-hydroxytetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30506", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde <=> acetate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56699", "l": "D-ribulose 5-phosphate + L-tryptophan <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48412", "l": "a globoside IV3GalNAc-Gb4Cer + H2O = a globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29390", "l": "CTP + H2O <=> CDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54804", "l": "2 4-sulfanylbutanoate + NAD(+) = 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.8.1.20", "l": "\"4,4'-dithiodibutanoate disulfide reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74734", "l": "rhamnetin + S-adenosyl-L-methionine <=> 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48682", "l": "a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH => a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36631", "l": "D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877385", "l": "RUNX1 binds intron 1 of IL2RA (CD25) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51904", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018776", "l": "trans-chloroacrylic acid dehalogenase activity", "d": ["Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32927", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49286", "l": "CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate => 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44789", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine => H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55044", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O = (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12208", "l": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.56", "l": "\"methylumbelliferyl-acetate deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51178", "l": "5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66755", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O <=> (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168400", "l": "iE-DAP elicits a NOD1 response (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52950", "l": "deoxycholoyl-24-O-(beta-D-glucuronate) + UDP => deoxycholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43141", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56352", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809561", "l": "I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55161", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876993", "l": "CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54449", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O => a tRNA + an N-acyl-L-amino acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933539", "l": "Recruitment of IKK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74986", "l": "Elongation of pre-rRNA transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58095", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69177", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20112", "l": "alpha-D-ribose 1,5-bisphosphate + ATP <=> 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0016748", "l": "succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23758", "l": "dehydro-D-arabinono-1,4-lactone + H(+) + H2O2 => D-arabinono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757688", "l": "SERPINA6 binds PREDN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28990", "l": "H(+)(in) + N-acetylneuraminate(in) <=> H(+)(out) + N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.66", "l": "\"XTP/dITP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211874", "l": "CYP2S1 4-hydroxylates atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766532", "l": "SQSTM1 oligomer is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17804", "l": "acetyl-CoA + L-phenylalanine <=> CoA + H(+) + N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46612", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60631", "l": "AH2 + gluconapin + O2 <=> A + H2O + progoitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050472", "l": "zeatin reductase activity", "d": ["Catalysis of the reaction: dihydrozeatin + NADP+ = H+ + NADPH + zeatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25023", "l": "CDP + FMN + H(+) => CTP + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54509", "l": "all-trans-heptaprenyl diphosphate => beta-heptaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.24", "l": "\"tubulin-glutamate carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130194", "l": "ABL phosphorylates WAVEs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13021", "l": "H(+) + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.82", "l": "\"vanillate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52253", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15971", "l": "glutathione disulfide + H2O + methylarsonous acid => 2 glutathione + H(+) + methylarsonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42817", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol => cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55971", "l": "(+)-kolavelool + S-adenosyl-L-methionine <=> (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669854", "l": "KIT binds type II TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53173", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004853", "l": "uroporphyrinogen decarboxylase activity", "d": ["Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62496", "l": "ATP + H(+) + L-arginine = diphosphate + L-arginyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52650", "l": "5-phospho-L-arabinonate + H(+) => H2O + L-arabino-1,4-lactone 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38882", "l": "a fatty acid(in) <=> a fatty acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16840", "l": "5'-acylphosphoadenosine + H2O <=> a carboxylate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69975", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] = (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56946", "l": "1-deoxy-D-xylulose 5-phosphate + A + H2O => AH2 + D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662653", "l": "MT4 binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961678", "l": "ORC1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203611", "l": "N-myristoylation of eNOS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627104", "l": "XIAP binds CASP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64760", "l": "H2O + S-ethyl-L-cysteine = ethanethiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50266", "l": "26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036433", "l": "di-trans, poly-cis-undecaprenol kinase activity", "d": ["Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781814", "l": "USP19 deubiquitinates RNF123 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31798", "l": "(+)-(E)-beta-caryophyllene + H2O <=> (+)-caryolan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25776", "l": "scyllo-inosose = scyllo-inosine", "d": [], "t": []}, {"i": "EC:5.3.99.11", "l": "\"2-keto-myo-inositol isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427514", "l": "eNoSC deacetylates histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48332", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39585", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712208", "l": "odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 dissociates yielding GNAL:GTP (G alpha-olf:GTP), odorant:OlfactoryReceptor, and GNB1:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49299", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39937", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086041", "l": "voltage-gated potassium channel activity involved in SA node cell action potential depolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58159", "l": "ATP + H2O + 4 Na(+)(in) <=> ADP + H(+) + 4 Na(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43956", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61978", "l": "5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62828", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621370", "l": "SYK autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18583", "l": "glycolaldehyde + H2O2 + NH4(+) => ethanolamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004358", "l": "glutamate N-acetyltransferase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55259", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047100", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity", "d": ["Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56066", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096537", "l": "Defective GALNT3 does not transfer GalNAc to mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65966", "l": "ADP + H(+) + phosphate + taurocholate(in) => ATP + H2O + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395364", "l": "LTBP4 binds TGF-Beta-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12806", "l": "(S)-canadine + S-adenosyl-L-methionine => (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710354", "l": "GSDME (1-270) binds cardiolipin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080011", "l": "baruol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56801", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide => cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102494", "l": "GA20 2,3-desaturase activity", "d": ["Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor = gibberellin A5 + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840488", "l": "PSAP(195-273) forms a dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17341", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11001", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O => a D-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58898", "l": "4-hydroxybutanoyl-CoA + ADP + phosphate => 4-hydroxybutanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018814", "l": "RHOT1 hydrolyzes GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66607", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17709", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54840", "l": "H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71588", "l": "(S)-malate(in) + 2-oxoglutarate(out) => (S)-malate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76686", "l": "ATP + CoA + sulfoacetate <=> ADP + phosphate + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749590", "l": "ASA- acetylates ALB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42137", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37389", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.24", "l": "\"mitogen-activated protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38510", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483186", "l": "PC is converted to PS by PTDSS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50510", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60101", "l": "cyanidin + UDP-alpha-D-glucose => cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110219", "l": "Cleavage of thymine by TDG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52949", "l": "deoxycholate + UDP-alpha-D-glucuronate => deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17797", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.29", "l": "\"cellulose synthase (GDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632670", "l": "CSNK1A1 phosphorylates SMO dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853762", "l": "RET dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59781", "l": "L-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0005021", "l": "vascular endothelial growth factor receptor activity", "d": ["Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76372", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23866", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57933", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62646", "l": "(5S)-hydroperoxy-(6E,8Z)-eicosadienoate => (5Z,8Z)-eicosadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69174", "l": "(2E)-2-butenoate + L-lysyl-[protein] => H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24287", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate <=> 4-phospho-L-aspartate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64288", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] = cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351948", "l": "Mitochondrial recruitment of Drp1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63051", "l": "H2O + pravastatin lactone <=> H(+) + pravastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63628", "l": "ATP + hexadecanoate + holo-[ACP] = AMP + diphosphate + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72587", "l": "(E)-sinapate + ATP + CoA = (E)-sinapoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8853496", "l": "SCF:FBXL7 binds AURKA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45373", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433456", "l": "Recruitment of STATs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67799", "l": "a ribonucleotidyl-ribonucleotide-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36541", "l": "CoA + H(+) + N-hexadecanoylsphinganine => hexadecanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31061", "l": "2 H(+) + imidazole-4-acetate + NADH => H2O + imidazole-4-acetaldehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14903", "l": "casbene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31854", "l": "(S)-2,3-epoxysqualene <=> parkeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40720", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404144", "l": "Parenchymal atROL translocates to HSCs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75297", "l": "chloride(out) + sulfate(in) => chloride(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033225", "l": "ATPase-coupled 2-aminoethylphosphonate transporter activity", "d": ["Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)."], "t": []}, {"i": "RHEA:32775", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O = (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31670", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197958", "l": "FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54254", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944246", "l": "Association of procollagen type XXI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56634", "l": "1,8-cineole + diphosphate => H2O + neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11439", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 <=> 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13541", "l": "H2O + tetrathionate = H(+) + sulfate + sulfur + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156910", "l": "Formation of eEF1B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29597", "l": "H(+) + NADPH + sulfoacetyl-CoA => CoA + NADP(+) + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197958", "l": "FPGS-2 transforms THF to THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827256", "l": "DUX4 binds MaLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371582", "l": "HSBP1 binds HSF1 trimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.81", "l": "\"hydroxypyruvate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23443", "l": "4-chlorobenzoate + H2O <=> 4-hydroxybenzoate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70914", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621370", "l": "SYK autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358791", "l": "Phosphorylation of USP8 by P-AKT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132094", "l": "C8 binds to C5b:C6:C7 complement complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004348", "l": "glucosylceramidase activity", "d": ["Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682010", "l": "ATG10:ATG12 binds ATG5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25371", "l": "(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": [], "t": []}, {"i": "EC:1.3.8.16", "l": "\"2-amino-4-deoxychorismate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44917", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (3E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15403", "l": "a dolichyl beta-D-glucosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671772", "l": "p-T38-PPP1R14A binds MLCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805109", "l": "CDK2 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76364", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200406", "l": "CPT1A,B transfers PALM to CAR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757540", "l": "PREDN,PREDL diffuse into GI cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56383", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65891", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29120", "l": "a ubiquinol + nitrate => a ubiquinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730858", "l": "Autophosphorylation of BTK/ITK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63153", "l": "an N-fatty acyl-taurine + H2O => a fatty acid + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681616", "l": "AP2 binds chlorpromazine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015186", "l": "L-glutamine transmembrane transporter activity", "d": ["Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37301", "l": "L-alanine + L-threonine => H2O + L-alanyl-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032548", "l": "pyrimidine deoxyribonucleoside binding", "d": ["Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481044", "l": "Surface deployment of platelet alpha granule membrane components (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32899", "l": "1,8-cineole + O2 + reduced [flavodoxin] = 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.14.14.133", "l": "\"1,8-cineole 2-endo-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.775903698273282", "identifiers": [{"i": "GO:0015279", "l": "store-operated calcium channel activity", "d": ["A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores."], "t": []}, {"i": "REACT:R-HSA-434798", "l": "CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15912", "l": "2-oxoglutarate + O2 + taurine <=> aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74372", "l": "a carboxylate(out) + nicotinate(in) => a carboxylate(in) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61267", "l": "H2O + L-alanine + O2 <=> H2O2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786155", "l": "POLN binds ICL-DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944254", "l": "Association of procollagen type XXVI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65932", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine = 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632914", "l": "TP53 binds the GLS2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474266", "l": "Formation of collagen fibrils (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102863", "l": "1-18:3-2-18:1-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210300", "l": "Interaction of DAP12 and TREM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928578", "l": "EPH receptors autophosphorylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49562", "l": "(R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate => D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38525", "l": "(9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47527", "l": "cholate + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12299", "l": "deacetylipecoside + H2O <=> dopamine + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22932", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.38", "l": "\"beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33382", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O <=> (4R)-hydroxyeicosasphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43963", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032854", "l": "NTRK2 phosphorylates CDK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034038", "l": "deoxyhypusine synthase activity", "d": ["Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602901", "l": "Defective GSS does not synthesize GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21140", "l": "ATP + inosine = ADP + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955844", "l": "RBKS phosphorylates ribose to R5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692539", "l": "HRH1 binds HRH1 inverse agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.32", "l": "\"maleylacetate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623643", "l": "RDH13 reduces atRAL to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27866", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + alpha-D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23719", "l": "(3Z)-dodecenoyl-CoA <=> (2E)-dodecenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806831", "l": "CYB5Rs reduce MetHb to HbA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40523", "l": "a quinone + succinate = a quinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-555065", "l": "Formation of clathrin coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50534", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52433", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106377", "l": "2-hydroxy-ATP hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635859", "l": "GLI:SUFU dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69814", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17591", "l": "H(+) + L-alanine + NADH + pyruvate => 2,2'-iminodipropanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71567", "l": "5-phosphomethyl-dUMP in DNA + L-serine = 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67234", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534365", "l": "Slo3 Potassium Transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12047", "l": "a triacylglycerol + H2O <=> a diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61880", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047672", "l": "anthranilate N-benzoyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0039706", "l": "co-receptor binding", "d": ["Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247844", "l": "WNT ligands traffic to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72067", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate = ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672980", "l": "Dissociation of RAS:RAF complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470483", "l": "Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0047935", "l": "glucose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.17", "l": "\"benzylmalonyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702818", "l": "CALCR binds erenumab (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28752", "l": "sn-glycerol 3-phosphate + ubiquinone-8 => dihydroxyacetone phosphate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19731", "l": "acetone + CO2 => acetoacetate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791235", "l": "GADD45A binds AURKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36643", "l": "emodin + S-adenosyl-L-methionine = H(+) + questin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.283", "l": "\"emodin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050271", "l": "S-alkylcysteine lyase activity", "d": ["Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.194", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9703895", "l": "CASR binds CASR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163770", "l": "Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466369", "l": "NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61928", "l": "(R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9612509", "l": "SGK phosphorylates SRF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61634", "l": "5-aminopentanoate + 2 H(+) + NADH => 5-aminopentanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59343", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A <=> 1'-hydroxy-demethylspheroidene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66491", "l": "quillate + UDP-alpha-D-glucose <=> quillaic acid 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13016", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218811", "l": "DOCK180:ELMO binds CRK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63426", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + diphosphate => (2S)-2-phospholactate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35207", "l": "H2O + IDP = H(+) + IMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46656", "l": "androst-4-ene-3,17-dione + H(+) + NADPH = 5beta-androstane-3,17-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38816", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36865", "l": "(9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O => (9Z)-octadecenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51708", "l": "D-altritol + NAD(+) = H(+) + keto-D-tagatose + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.407", "l": "\"D-altritol 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805943", "l": "S100A1 binds TLR4:LY96 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32504", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44662", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203480", "l": "COLEC11 binds ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17723", "l": "a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004711", "l": "ribosomal protein S6 kinase activity", "d": ["Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395517", "l": "NADPH transfers electrons to FDXR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419490", "l": "Binding of ATP to P2X receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416698", "l": "SEMA5A binds to PLXNB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36632", "l": "D-ribulose 1,5-bisphosphate + O2 => (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64893", "l": "holo-[ACP] + tetradecanoyl-AMP => AMP + H(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49414", "l": "alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534040", "l": "Unknown NAT N-acylates Gly in GNAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26262", "l": "H2O + isopimara-7,15-dienal + NADP(+) => 2 H(+) + isopimarate + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016154", "l": "pyrimidine-nucleoside phosphorylase activity", "d": ["Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate."], "t": []}, {"i": "EC:2.4.2.2", "l": "\"pyrimidine-nucleoside phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379387", "l": "COMT transfers Met to DA to form 3MT (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27747", "l": "H(+) + L-cysteine => CO2 + cysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611839", "l": "β3-agonists bind ADRB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60333", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55432", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.61", "l": "\"carnosic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61107", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65632", "l": "a sphingoid base + tetracosanoyl-CoA = an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44351", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21410", "l": "3-phenylpyruvate + H(+) + NADH + NH4(+) => H2O + L-phenylalanine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379844", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43601", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH => 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621073", "l": "Immediate Early (IE) Gene Expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24194", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67229", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74851", "l": "acetaldehyde + dopamine = (R)-salsolinol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110307", "l": "REV1 binds AP-dsDNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10455", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941895", "l": "Formation of CDK4/6:CCND complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-825631", "l": "Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445699", "l": "ATP Hydrolysis By Myosin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419166", "l": "GEFs activate RhoA,B,C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64460", "l": "acetyl phosphate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47195", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] <=> Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39784", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64033", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30801", "l": "acetoacetyl-CoA + H(+) + NADH => (3S)-3-hydroxybutanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005980", "l": "IL21 binds IL21R:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47431", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) <=> 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004583", "l": "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247837", "l": "WNT ligands traffic to the Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11131", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12951", "l": "2-dehydro-3-deoxy-D-fuconate + H2O => D-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52456", "l": "testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18958", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19155", "l": "7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP => apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21665", "l": "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445714", "l": "Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22363", "l": "D-glutamate <=> 5-oxo-D-proline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19061", "l": "H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445069", "l": "L1-EGFR trans-heterodimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65815", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 <=> A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034853", "l": "2,4,4-trimethyl-3-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48588", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9840564", "l": "OMA1 hydrolyzes YME1L1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77298", "l": "a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42153", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693575", "l": "DNA-PKcs autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68544", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015190", "l": "L-leucine transmembrane transporter activity", "d": ["Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71185", "l": "L-kynurenine(in) + L-tryptophan(out) => L-kynurenine(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.120", "l": "\"galactose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72105", "l": "Na(+)(in) + O-propanoyl-(R)-carnitine(in) => Na(+)(out) + O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437230", "l": "L1-FGFR cis-heterodimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20859", "l": "an N-acylsphing-4-enine + H2O <=> a fatty acid + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192051", "l": "CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29561", "l": "1-phospho-alpha-D-glucuronate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28607", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.47", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74634", "l": "3-methyl-2-oxobutanoate + O-acetyl-L-homoserine <=> (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37381", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75558", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59850", "l": "(S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65687", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102122", "l": "gibberellin A34 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52292", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23716", "l": "(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030274", "l": "LIM domain binding", "d": ["Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655326", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759860", "l": "FOXF1 binds the GATA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990640", "l": "inositol-2,4,5-triphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59036", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30118", "l": "decanoyl-[ACP] + H2O <=> decanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25765", "l": "3-carboxy-2-oxobutanoate + H(+) + NADH => (2R,3S)-3-methylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51394", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-serotonin => (9Z)-octadecenoyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52340", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] = AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44453", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18744", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA <=> 10-deacetylbaccatin III + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37645", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51198", "l": "chloride(in) + Na(+)(in) + serotonin(in) => chloride(out) + Na(+)(out) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50776", "l": "hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48496", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose = 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76204", "l": "n H(+)(out) + pyridoxine(out) => n H(+)(in) + pyridoxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53233", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015418", "l": "ABC-type quaternary ammonium compound transporting activity", "d": ["Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22128", "l": "(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.227", "l": "\"(-)-borneol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13055", "l": "3-phenylpyruvate + L-alanine => L-phenylalanine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696482", "l": "CTF1 binds LIFR:JAKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73192", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA => (2R,3S,11R)-acetylaszonalenin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625424", "l": "The retrograde IFT train dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635861", "l": "NUMB:ITCH binds GLI1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65814", "l": "A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61163", "l": "quercetin + UDP-beta-L-rhamnose <=> H(+) + quercitrin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40192", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16062", "l": "H2O + sn-glycerol 3-phosphocholine => choline + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.52", "l": "\"calpain-1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047997", "l": "hydroxypyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-hydroxypyruvate + H+ = CO2 + glycolaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611277", "l": "P2RY12 binds P2RY12 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371554", "l": "HSF1 acetylation at Lys80 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614618", "l": "Persulfide sulfur is transferred onto sulfite (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30428", "l": "(2E,6E)-farnesyl diphosphate => (+)-germacrene D + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74550", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + talarodiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63036", "l": "H2O + octadecanamide = NH4(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73954", "l": "(2E,6E)-farnesyl diphosphate <=> beta-maaliene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63810", "l": "AMP + diphosphate + H(+) + N(8)-citryl-spermidine => ATP + citrate + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40790", "l": "H2O + tetracosanoyl-CoA <=> CoA + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45599", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867613", "l": "PICALM binds R-SNAREs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59174", "l": "AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58391", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate <=> 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53146", "l": "H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73952", "l": "(2E,6E)-farnesyl diphosphate => beta-maaliene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034807", "l": "4,5-dihydroxybenzo(a)pyrene methyltransferase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804099", "l": "HMGB1 binds LTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19480", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19556", "l": "H2O + L-tryptophan <=> indole + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72095", "l": "Internal Methylation of mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60608", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793921", "l": "Expression of DLL1 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839073", "l": "HTRA2 binds NDUFA13 (GRIM-19) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53604", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380316", "l": "Association of NuMA with microtubules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12678", "l": "AH2 + Latia luciferin + 2 O2 => A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864577", "l": "TFAP2C translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42566", "l": "pseudouridine(38/39) in tRNA => uridine(38/39) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12658", "l": "a (2S)-2-methylacyl-CoA => a (2R)-2-methylacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42601", "l": "AH2 + prostaglandin G2 => A + H2O + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012835", "l": "GDIs block activation of RHOA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46566", "l": "acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+) => acetyl-CoA + apo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51308", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454928", "l": "ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425861", "l": "Activation of Protein Kinase C novel isoforms (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73789", "l": "diphosphate + variecolorin L => dimethylallyl diphosphate + tardioxopiperazine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73208", "l": "sulfate(out) + sulfite(in) => sulfate(in) + sulfite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047658", "l": "alpha-amino-acid esterase activity", "d": ["Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420121", "l": "SFKs phosphorylate PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047490", "l": "pectin lyase activity", "d": ["Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72511", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) + 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215391", "l": "PRMT5 is tyrosine phosphorylated by JAK2 V617F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37918", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004827", "l": "proline-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35882", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102914", "l": "N-methyl-3-aminomethylindole N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983156", "l": "Polyubiquitination of substrate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34584", "l": "2-oxoglutarate + O2 + pentalenolactone D => CO2 + H2O + pentalenolactone E + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77183", "l": "L-threonine + uridine-5'-aldehyde = (5'S,6'R)-C-glycyluridine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018565", "l": "dihydroxydibenzothiophene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58633", "l": "N-tetradecanoyl-(2S)-hydroxyglycine => glyoxylate + tetradecamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29142", "l": "2 H(+)(in) + menaquinol-8 + nitrate <=> 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24420", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]", "d": [], "t": []}, {"i": "EC:3.5.1.88", "l": "\"peptide deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61810", "l": "AMP + H(+) + L-alanyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728664", "l": "GLP1R binds GLP1R agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.91", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0099104", "l": "potassium channel activator activity", "d": ["Binds to and increases the activity of a potassium channel, resulting in its opening."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678418", "l": "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948757", "l": "AKT phosphorylates MKRN1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189062", "l": "lactose + H2O => D-glucose + D-galactose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49196", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050124", "l": "N-acylneuraminate-9-phosphatase activity", "d": ["Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72149", "l": "3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + S-adenosyl-L-methionine + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22008", "l": "L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine", "d": [], "t": []}, {"i": "EC:2.3.1.46", "l": "\"homoserine O-succinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0099511", "l": "voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels", "d": ["Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20679", "l": "1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP => alizarin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666008", "l": "SCAI binds SRF:MKL1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19367", "l": "ADP + D-ribulose 1,5-bisphosphate + H(+) => ATP + D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814764", "l": "Plasma membrane resorption (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205262", "l": "Direct recruitment of PI3K to p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381608", "l": "cAMP activates EPAC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917700", "l": "MVB Vesicle Formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0016411", "l": "acylglycerol O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70510", "l": "LDH tetramer oxidises LACT to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38414", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686430", "l": "MUS81 binds EME1, EME2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35717", "l": "(2S-3S)-versiconal hemiacetal + acetate + H(+) => (2S,3S)-versiconal hemiacetal acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10426", "l": "benzoate + glycine => H2O + N-benzoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55393", "l": "an adenosine in mRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67299", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726580", "l": "PGR binds PGR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220978", "l": "FBXW7 WD mutants do not bind NICD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31714", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37176", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51084", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68835", "l": "(2Z,6Z)-farnesyl diphosphate + H2O <=> (6Z)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19962", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate => a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14506", "l": "2 glutathione + thiosulfate => glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010012", "l": "steroid 22-alpha hydroxylase activity", "d": ["Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052636", "l": "arabinosyltransferase activity", "d": ["Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047959", "l": "glycine dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22257", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) => a 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33725", "l": "a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44890", "l": "1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72094", "l": "(R)-carnitine(out) + Na(+)(out) <=> (R)-carnitine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43322", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2870221", "l": "E-selectin binds E-selectin ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61375", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O <=> 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47640", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877153", "l": "STARD7 binds PC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005368", "l": "taurine transmembrane transporter activity", "d": ["Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940007", "l": "MMP13 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64554", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62632", "l": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.27", "l": "\"glutathione-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64503", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852317", "l": "PLK1 phosphorylates GTSE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21146", "l": "5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45423", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39139", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66753", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76245", "l": "[protein]-C-terminal glycine + N-terminal glycyl-[protein] => a glycyl-glycyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102220", "l": "hydrogenase activity (NAD+, ferredoxin)", "d": ["Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848726", "l": "PTK6 phosphorylates BCAR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22060", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:2.8.1.6", "l": "\"biotin synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448632", "l": "IL34 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21865", "l": "an S-(2-hydroxyacyl)glutathione + H2O => a 2-hydroxy carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218642", "l": "PTK2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004502", "l": "kynurenine 3-monooxygenase activity", "d": ["Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.45", "l": "\"E1 ubiquitin-activating enzyme\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42181", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031691", "l": "alpha-1A adrenergic receptor binding", "d": ["Binding to an alpha-1A adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17455", "l": "ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => 5-phospho-beta-D-ribosylamine + ATP + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13625", "l": "A + H2O + N(6)-dimethylallyladenine = 3-methyl-2-butenal + adenine + AH2", "d": [], "t": []}, {"i": "EC:1.5.99.12", "l": "\"cytokinin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66473", "l": "(2Z,6E,10E,14E)-geranylfarnesol => 18-episcalar-17(25)-en-19-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.213", "l": "\"3alpha-hydroxysteroid dehydrogenase (Re-specific)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72758", "l": "3 ATP <=> 3',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68529", "l": "(2E,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46350", "l": "3-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42898", "l": "H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine => L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2314678", "l": "ASA- acetylates PTGS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18309", "l": "an N-acyl-D-amino acid + H2O = a carboxylate + a D-alpha-amino acid", "d": [], "t": []}, {"i": "EC:3.5.1.81", "l": "\"N-acyl-D-amino-acid deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51944", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.343", "l": "\"8-amino-8-demethylriboflavin N,N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2152276", "l": "Secretion of transmembrane collagens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75860", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51135", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34289", "l": "2 H2O + 2 L-dopaquinone => 2 L-dopa + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451345", "l": "DSCAM binds DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445072", "l": "Interaction of PAK1 with Rac1-GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870465", "l": "RGGT binds the RAB-binding subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34476", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => 15-cis-phytoene + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009485", "l": "IL34:CSF1 binds CSF1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64401", "l": "an L-amino acid tripeptide(out) + H(+)(out) => an L-amino acid tripeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73932", "l": "Resynthesis of excised residue by POLB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38508", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52857", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018756", "l": "RHOH binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015364", "l": "dicarboxylate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205244", "l": "Recruitment of CBL to KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047586", "l": "5'-acylphosphoadenosine hydrolase activity", "d": ["Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678925", "l": "NR3C1 binds NR3C1 agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694308", "l": "3a is externalized together with membrane structures (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24266", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone => D-xylulose 5-phosphate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839078", "l": "Cytosolic FGFR1 fusion proteins bind PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483089", "l": "PE is converted to PS by PTDSS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23305", "l": "atropine + H2O => H(+) + tropate + tropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030784", "l": "3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696267", "l": "RND3 binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180627", "l": "Interaction of Vpr with importin alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210298", "l": "Interaction of DAP12 and KIR3DS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59271", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] <=> AH2 + formaldehyde + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047498", "l": "calcium-dependent phospholipase A2 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+."], "t": []}, {"i": "REACT:R-HSA-111883", "l": "Hydrolysis of phosphatidylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40999", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47525", "l": "cholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10419", "l": "fumarate + toluene <=> 2-benzylsuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015147", "l": "L-arabinose transmembrane transporter activity", "d": ["Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57111", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72099", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) = Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420975", "l": "Ca impermeable AMPA receptor ligand binding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55042", "l": "3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.5", "l": "\"nucleoside ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48248", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60802", "l": "CO2 + gibberellin A44 + succinate => 2-oxoglutarate + gibberellin A53 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.365", "l": "\"protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193981", "l": "CYP21A2 oxidises 17HPROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047748", "l": "cholestanetetraol 26-dehydrogenase activity", "d": ["Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67917", "l": "adenosine 5'-phosphoramidate + H2O => AMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203977", "l": "SAR1 Activation And Membrane Binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67437", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318373", "l": "Defective GUSB does not hydrolyse (HA)2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32853", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008481", "l": "sphinganine kinase activity", "d": ["Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781953", "l": "YOD1 binds VCP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41211", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 = 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.235", "l": "\"indole-3-acetate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77622", "l": "2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) <=> a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30712", "l": "(S)-linalool => beta-myrcene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23562", "l": "adenosylcob(III)alamin 5'-phosphate + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74614", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) <=> UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5606996", "l": "Soluble PROCR binds activated protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004379", "l": "glycylpeptide N-tetradecanoyltransferase activity", "d": ["Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011966", "l": "Estrogen-responsive KDM4B gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16093", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76768", "l": "emodin + S-adenosyl-L-methionine => physcion + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783681", "l": "LIF binds LIFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050500", "l": "1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity", "d": ["Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937177", "l": "AHR:TCDD binds ARNT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53926", "l": "a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine => a secondary amine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44884", "l": "a cardiolipin + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38370", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11134", "l": "H(+) + NADPH + protochlorophyllide a => chlorophyllide a + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57155", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445079", "l": "Phosphorylation of L1 by ERK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050323", "l": "taurine dehydrogenase activity", "d": ["Catalysis of the reaction: A + H2O + taurine = AH(2) + NH4 + sulfoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23403", "l": "7,8-dihydroxykynurenate + O2 <=> 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67830", "l": "a lipid A disaccharide + H(+) + UDP => a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684261", "l": "MAP3K8 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72042", "l": "nicotinate(in) + orotate(out) <=> nicotinate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73226", "l": "(3S)-citramalate(in) + sulfate(out) <=> (3S)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798528", "l": "S100A8:S100A9 binds Mn2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69126", "l": "glycine + indole-3-pyruvate => glyoxylate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964759", "l": "Alternative endo-mannosidase I route (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59910", "l": "2 H(+) + hexanoate + NADPH => H2O + hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20621", "l": "ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out)", "d": [], "t": []}, {"i": "EC:7.2.2.12", "l": "\"P-type Zn(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72750", "l": "leukotriene E4(out) <=> leukotriene E4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44785", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine => H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.31", "l": "\"RBR-type E3 ubiquitin transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.335082997926719", "identifiers": [{"i": "GO:0016811", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22621", "l": "H(+) + L-tryptophan + O2 => 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0042577", "l": "lipid phosphatase activity", "d": ["Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42202", "l": "11-dehydrocorticosterone + H(+) + NADPH => corticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004632", "l": "phosphopantothenate--cysteine ligase activity", "d": ["Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59404", "l": "L-homoserine = D-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0005165", "l": "neurotrophin receptor binding", "d": ["Binding to a neurotrophin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6795473", "l": "PDPK1 phosphorylates SGK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35394", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10488", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.3.3.2", "l": "\"5-formyltetrahydrofolate cyclo-ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37047", "l": "H(+)(out) + L-histidine(out) = H(+)(in) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873917", "l": "Translocation of STAT1 dimer to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50498", "l": "CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein] => acetyl-CoA + N-terminal glycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41665", "l": "dihydrochelirubine + NAD(+) => chelirubine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60361", "l": "FMN + H(+) + oxidized coenzyme F420-0 => dehydro coenzyme F420-0 + FMNH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63169", "l": "fumarate + L-cysteine => S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.218", "l": "\"alpha-3'-ketoglucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20637", "l": "D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol", "d": [], "t": []}, {"i": "EC:1.1.99.28", "l": "\"glucose-fructose oxidoreductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48102", "l": "H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28183", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate => (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39747", "l": "cholesterol(in) = cholesterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38911", "l": "avenacoside B + H2O = 26-desgluco-avenacoside B + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.188", "l": "\"avenacosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28471", "l": "pyridoxine(in) => pyridoxine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788974", "l": "Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55685", "l": "chorismate + NH4(+) => 4-amino-4-deoxychorismate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75690", "l": "ATP(in) <=> ATP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008476", "l": "RUNX2 binds GSK3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69685", "l": "CHEK2 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39303", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA = (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31663", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}, {"i": "EC:2.6.1.34", "l": "\"UDP-N-acetylbacillosamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46814", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912357", "l": "ITCH ubiquitinates DTX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11584", "l": "L-ornithine = D-ornithine", "d": [], "t": []}, {"i": "EC:5.1.1.12", "l": "\"ornithine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218812", "l": "FYN phosphorylates PAK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62422", "l": "a fatty acid + CO2 + H2O => a (R)-2-hydroxy fatty acid + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55843", "l": "calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24383", "l": "(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21829", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67261", "l": "(E)-hept-2-enal + H2O + NAD(+) => (E)-hept-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38434", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43979", "l": "H(+) + hexadecanoate + NADPH + O2 <=> 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13321", "l": "(R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.84", "l": "\"dimethylmalate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102703", "l": "camphene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (-)-camphene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983147", "l": "Release of E3 from polyubiquitinated substrate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49987", "l": "H(+) + jasmonate + NADPH + O2 <=> (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211968", "l": "CYP2W1 oxidises INDOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983153", "l": "E1 mediated ubiquitin activation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75645", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50435", "l": "AH2 + prostaglandin G1 <=> A + H2O + prostaglandin H1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25356", "l": "2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008742", "l": "L-ribulose-phosphate 4-epimerase activity", "d": ["Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046576", "l": "rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity", "d": ["Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39153", "l": "(3R)-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419166", "l": "GEFs activate RhoA,B,C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507868", "l": "Aquaporins passively transport water into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44283", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451377", "l": "Interaction of IQGAP1 with nephrin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801762", "l": "REG3A oligomerize to form a pore complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964619", "l": "PAK1 binds ARHGEF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61629", "l": "5-aminopentanal => 1-piperideine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50711", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione <=> (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70971", "l": "citrate <=> isocitrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30835", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12212", "l": "9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35281", "l": "3-oxooctadecanoyl-CoA + CoA => acetyl-CoA + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73171", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) = adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638104", "l": "UGCG transfers glucose to ceramide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53879", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47535", "l": "chenodeoxycholate + NAD(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57609", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-chlorocatechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62094", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450975", "l": "isocitrate <=> citrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102457", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose = H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3787997", "l": "Laminin-332 binds collagen type VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18484", "l": "cyclohexylsulfamate + H2O <=> cyclohexylamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209118", "l": "Membrane localised SGG phosphorylates ARR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55305", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37169", "l": "(2E,6E)-farnesal + H(+) + NADH => (2E,6E)-farnesol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0009008", "l": "DNA-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to a DNA molecule."], "t": []}, {"i": "REACT:R-HSA-5227490", "l": "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34917", "l": "D-galactose(out) => D-galactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37071", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549470", "l": "Expression of CRYPTOCHROME-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681980", "l": "ATG12 binds ATG7 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655339", "l": "Activated FGFR2 mutants bind FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30435", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": [], "t": []}, {"i": "EC:2.3.2.16", "l": "\"lipid II:glycine glycyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56562", "l": "[1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP => [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25638", "l": "H2O + NAD(+) + sulfoacetaldehyde => 2 H(+) + NADH + sulfoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71528", "l": "thymine(out) => thymine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.55", "l": "\"venombin AB\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940309", "l": "Expression of PERM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044716", "l": "8-oxo-GDP phosphatase activity", "d": ["Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987043", "l": "IL22RA1 binds JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14081", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + indole", "d": [], "t": []}, {"i": "EC:4.1.2.8", "l": "\"indole-3-glycerol-phosphate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50134", "l": "ethanol + H(+) + hexadecanoate => ethyl hexadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370505", "l": "PRLR is phosphorylated at Ser-349 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15422", "l": "a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656230", "l": "Defective B4GALT1 does not transfer Gal to the keratan chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165195", "l": "GTP loading by Rheb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13389", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.6", "l": "\"glutaryl-CoA dehydrogenase (ETF)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39150", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23465", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21923", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050240", "l": "pyrogallol 1,2-oxygenase activity", "d": ["Catalysis of the reaction: O2 + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.18", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72565", "l": "butanoate(in) + dehydroepiandrosterone 3-sulfate(out) => butanoate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426489", "l": "RISC binds inexactly matching target RNAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33023", "l": "6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59425", "l": "benzylamine + H2O + O2 => benzaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961620", "l": "E2F1 binds the CDC6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32070", "l": "8-oxoguanine + H(+) + H2O <=> NH4(+) + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40820", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19661", "l": "D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.17", "l": "\"mannitol-1-phosphate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399942", "l": "Plexin-A1-4 binds NRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11883", "l": "(S)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52657", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) => a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59793", "l": "H2O + NADP(+) + yersinopine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.17", "l": "\"guanidinopropionase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46313", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA => 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909738", "l": "SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.221379778443747", "identifiers": [{"i": "GO:0140678", "l": "molecular function inhibitor activity", "d": ["A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718379", "l": "GNRHR binds chemical antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646468", "l": "mTORC1 binds RHEB:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807826", "l": "LDHAL6B reduces PYR to LACT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67568", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate = adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33594", "l": "sphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.41", "l": "\"cathepsin F\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045174", "l": "glutathione dehydrogenase (ascorbate) activity", "d": ["Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783883", "l": "P6C transforms to 2AMAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51912", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47727", "l": "glutathione <=> 5-oxo-L-proline + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.994485457618666", "identifiers": [{"i": "GO:0016798", "l": "hydrolase activity, acting on glycosyl bonds", "d": ["Catalysis of the hydrolysis of any glycosyl bond."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41299", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15615", "l": "2 H(+) + NADH + sirohydrochlorin => NAD(+) + precorrin-2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65032", "l": "3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38924", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH => a ubiquinol + Na(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199131", "l": "PVR binds CD226 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73649", "l": "CTP(in) + IMP(out) => CTP(out) + IMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.-.-.-", "l": "\"Oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71687", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60988", "l": "(E)-hex-2-en-1-ol + NAD(+) = (E)-hex-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60775", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624956", "l": "PDE6D binds INPP5E (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20702", "l": "ADP + H(+) + lipid IVA (E. coli) => ATP + lipid A disaccharide (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474210", "l": "Collagen type III degradation by MMP14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31455", "l": "NAD(+) + reduced riboflavin = 2 H(+) + NADH + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20561", "l": "3-hydroxypyruvate + H(+) = CO2 + glycolaldehyde", "d": [], "t": []}, {"i": "EC:4.1.1.40", "l": "\"hydroxypyruvate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21741", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015345", "l": "ferric enterobactin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43641", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001635", "l": "calcitonin gene-related peptide receptor activity", "d": ["Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41301", "l": "(9Z)-octadecenoate + sphing-4-enine => H2O + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19181", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.9", "l": "\"very-long-chain acyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9032798", "l": "DOCK3 activates RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63207", "l": "H2O + octadecanoyl-[ACP] <=> H(+) + holo-[ACP] + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69140", "l": "RPA binds to the Flap (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008659", "l": "(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O."], "t": []}, {"i": "RHEA:41892", "l": "(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22127", "l": "17-O-acetylajmaline + H2O <=> acetate + ajmaline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419440", "l": "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46301", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37435", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47245", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70137", "l": "28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65750", "l": "CO2 + dodecanal + H(+) + succinate + sulfate => 2-oxoglutarate + dodecyl sulfate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53189", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32830", "l": "ATP + H2O + methionine(out) <=> ADP + H(+) + methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21930", "l": "2,3-dioxo-L-gulonate + H(+) + NADPH => 3-dehydro-L-gulonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60088", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31321", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP => (2R)-3-phosphoglycerate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62017", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60567", "l": "2-deoxy-D-glucose + ATP <=> 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61640", "l": "H(+) + isophthalyl-CoA = benzoyl-CoA + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.118", "l": "\"isophthalyl-CoA decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35641", "l": "glyoxylate + pyruvate => (4S)-4-hydroxy-2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13746", "l": "ascopyrone M => microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22538", "l": "(S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine => (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55671", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) <=> 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45826", "l": "CO2 + ethanolamine => H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848758", "l": "PTK6 phosphorylates AKT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18495", "l": "CoA + H(+) + N-benzoylglycine => benzoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.25", "l": "\"lipopolysaccharide heptosyltransferase III\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38331", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990136", "l": "linoleate 9S-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75805", "l": "butanoate(in) + Na(+)(in) => butanoate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36906", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36245", "l": "(E)-coumaryl acetate + NADPH => (E)-anol + acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161790", "l": "20cooh-LTB4 is converted to 18cooh-LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225649", "l": "RBBP7 binds histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46958", "l": "(E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390674", "l": "ADRB1 bind ADR,NAd (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102518", "l": "(11Z)-eicosenoate 14-hydroxylase activity", "d": ["Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12834", "l": "an N-acyl-D-glutamate + H2O => a carboxylate + D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45558", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine => H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426147", "l": "SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63719", "l": "losartan + UDP-alpha-D-glucuronate <=> losartan-1-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26272", "l": "Co-precorrin-2 + 3 H(+) <=> Co(2+) + precorrin-2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16756", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.35", "l": "\"(R)-2-methylmalate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59397", "l": "L-leucine => D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68232", "l": "L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14739", "l": "3',5'-cyclic CMP + diphosphate => CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13572", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48037", "l": "a globoside Gb4Cer (d18:1(4E)) + H2O => a globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30849", "l": "(2E)-butenoyl-CoA + CO2 + FADH2 => FAD + glutaryl-CoA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696547", "l": "STAMBPL1 is a deubiquitinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61713", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-593685", "l": "Netrin-4 binds DCC/UNC5A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13739", "l": "an alk-2-enal + H(+) + NADPH => an n-alkanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38595", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16573", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17329", "l": "(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.198", "l": "\"(+)-borneol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.69", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71507", "l": "(+)-alpha-tocopherol(out) = (+)-alpha-tocopherol(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14335", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047421", "l": "N-acyl-D-glutamate deacylase activity", "d": ["Catalysis of the reaction: N-acyl-D-glutamate + H2O = D-glutamate + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50418", "l": "H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41788", "l": "acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.38", "l": "\"[acyl-carrier-protein] S-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40536", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60041", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate => (2E)-3-methylhex-2-enoate + L-glutamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647593", "l": "EP400 binds CDKN1A promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24682", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033931", "l": "endogalactosaminidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670149", "l": "TERRA transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49293", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17194", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69093", "l": "H2O + NAD(+) + pentanal => 2 H(+) + NADH + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21580", "l": "(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.5", "l": "\"acetolactate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74829", "l": "UDP-alpha-D-galacturonate(out) + UMP(in) => UDP-alpha-D-galacturonate(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17090", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58330", "l": "(Z)-non-6-enal + H(+) + NADPH => (Z)-non-6-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53474", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20243", "l": "N-methylnicotinate + S-adenosyl-L-homocysteine => nicotinate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73487", "l": "a carboxylate(in) + orotate(out) = a carboxylate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655193", "l": "KIAA0101 double monoubiquitination (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18296", "l": "ATP + CoA + oxalate <=> AMP + diphosphate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77041", "l": "4-hydroxyhexan-3-one + H(+) + NADH + NH4(+) => 4-hydroxyhexan-3-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810894", "l": "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981610", "l": "Neuroglobin binds oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74935", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 = (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49965", "l": "5,10-dihydrophenazine + O2 => H2O2 + phenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694345", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40551", "l": "demethylphylloquinol + S-adenosyl-L-methionine = H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.329", "l": "\"demethylphylloquinol methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678992", "l": "Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098603", "l": "selenol Se-methyltransferase activity", "d": ["Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine."], "t": []}, {"i": "REACT:R-HSA-2408544", "l": "AdoSeMet is converted to AdeSeHCys by MetTrans(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706304", "l": "Active FLT3 binds to GRAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714580", "l": "SLC6A3 binds DRIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804099", "l": "HMGB1 binds LTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433576", "l": "3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748996", "l": "GST dimers cleave AZA to 6MP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49370", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45845", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) => 3-oxooctanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653742", "l": "ATF4 and a CEBP protein bind the ATF5 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749197", "l": "ORC1 binds to H4K20me2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69173", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-2-butenoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0043773", "l": "coenzyme F420-0 gamma-glutamyl ligase activity", "d": ["Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004304", "l": "estrone sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005287", "l": "high-affinity basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23601", "l": "2-oxoglutarate + L-2-aminohexanoate => 2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70138", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35315", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49590", "l": "D-erythrulose 4-phosphate => L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66075", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56693", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820807", "l": "Expression of TUT7 in the embryo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28346", "l": "7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate", "d": [], "t": []}, {"i": "EC:5.1.99.7", "l": "\"dihydroneopterin triphosphate 2'-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21812", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.23", "l": "\"cholesterol 7alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004353", "l": "glutamate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296309", "l": "HCAR3 binds HCAR3 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980065", "l": "NOTCH1 stimulates HEY transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62846", "l": "beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954082", "l": "E2F6 binds the PRC1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202969", "l": "Caspase mediated cleavage of beta-catenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76863", "l": "benzylamine + H2O + NAD(+) = benzaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10411", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA <=> 3-oxopristanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.755473255981116", "identifiers": [{"i": "GO:0016703", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696491", "l": "CNTF binds CNTFR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44313", "l": "1-tetradecanoylglycerol + H2O => glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31350", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O <=> 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35421", "l": "an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23825", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) => 2,3-dihydroxybenzoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376419", "l": "Formation of NR-MED1 Coactivator Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74711", "l": "Phosphorylation of IRS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050279", "l": "sepiapterin deaminase activity", "d": ["Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376134", "l": "NrCAM binds synapse-associated proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.21", "l": "\"beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046537", "l": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37578", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327746", "l": "FN1 aggregation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27634", "l": "5-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32918", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) <=> sn-glycero-3-phospho-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33119", "l": "(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.129", "l": "\"(+)-sativene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0035173", "l": "histone kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111956", "l": "Calmodulin activates Cam-PDE 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76059", "l": "heliamine + S-adenosyl-L-methionine = H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050402", "l": "xylono-1,4-lactonase activity", "d": ["Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353435", "l": "Elongation by Pol eta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67875", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656209", "l": "Dissociation of RAS:RAF1 mutant complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41475", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265456", "l": "NPC1L1 binds ezetimibe (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76546", "l": "N-acetyl-S-(2-succino)-L-cysteine <=> fumarate + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45241", "l": "a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664270", "l": "Recruitment of PLCgamma to membrane due to FCGR3A effect (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0017089", "l": "glycolipid transfer activity", "d": ["Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31704", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47137", "l": "ATP + CoA + lithocholate => AMP + diphosphate + lithocholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668904", "l": "Formation of the CTF18 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398040", "l": "Gbeta:gamma activation of PLC beta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71871", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69190", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948775", "l": "MKRN1 polyubiquitinates PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64625", "l": "(2E)-geraniol + acetyl-CoA => (2E)-geranyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33566", "l": "(4R)-hydroxysphinganine + ATP <=> (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225649", "l": "RBBP7 binds histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34931", "l": "glutathioselenol + NADPH = glutathione + hydrogenselenide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11005", "l": "2 H(+) + NADH + O2 + salicylate => catechol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668831", "l": "CST complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24483", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O <=> a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74651", "l": "CTP + N-acetyl-D-glucosamine = CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37427", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17116", "l": "H2O + L-serine-phosphoethanolamine <=> H(+) + L-serine + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66891", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62564", "l": "(4S)-limonene + A + H2O = (4S)-perillyl alcohol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450975", "l": "isocitrate <=> citrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2167942", "l": "Collagen type XIII ectodomain shedding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27740", "l": "2-deoxy-alpha-D-ribose 1-phosphate + guanine => 2'-deoxyguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21037", "l": "2 acetyl-CoA => acetoacetyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21465", "l": "2 H(+) + H2O + thiocyanate => carbonyl sulfide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781926", "l": "Defective PMM2 does not isomerise Man6P to Man1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59145", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70453", "l": "a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate => 2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76094", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114684", "l": "Phosphorylation of Syntaxin-4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052690", "l": "trichloro-p-hydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36919", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44722", "l": "a 1-acyl-sn-glycerol + H(+) + phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917730", "l": "Cargo Recognition And Sorting (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23757", "l": "D-arabinono-1,4-lactone + O2 => dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102964", "l": "S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine = H+ + magnoflorine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19289", "l": "H2O + sucrose 6(F)-phosphate = phosphate + sucrose", "d": [], "t": []}, {"i": "EC:3.1.3.24", "l": "\"sucrose-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47388", "l": "a tetradecanoate ester + H2O = an aliphatic alcohol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-500708", "l": "GRIK3 homomer binds glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19125", "l": "glyoxylate + L-serine = 3-hydroxypyruvate + glycine", "d": [], "t": []}, {"i": "EC:2.6.1.45", "l": "\"serine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38878", "l": "uridine(2604) in 23S rRNA <=> pseudouridine(2604) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167408", "l": "The high affinity receptor complex binds to G-protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109701", "l": "PDPK1 binds PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.58", "l": "\"8-oxo-dGDP phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614271", "l": "Autocleavage of ADGRG6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21654", "l": "catechol + chloride + CO2 + NAD(+) => 2-chlorobenzoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71275", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) = 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34984", "l": "sulfate(in) => sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006873", "l": "IL21 receptor STAT binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30466", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654511", "l": "FGFRL1 dimer binds FGFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17435", "l": "AH2 + betaine aldehyde => A + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.36", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73746", "l": "2 H(+)(out) + serotonin(in) <=> 2 H(+)(in) + serotonin(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315483", "l": "Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-500708", "l": "GRIK3 homomer binds glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928604", "l": "SFKs phosphorylate VAV2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15092", "l": "(R)-lactate + A <=> AH2 + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351208", "l": "Spermidine  => N-acetylated spermidine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72820", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654515", "l": "KAL1 binds HS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19553", "l": "H2O + L-tryptophan = indole + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.99.1", "l": "\"tryptophanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54505", "l": "all-trans-hexaprenyl diphosphate => beta-hexaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23660", "l": "4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.2.7", "l": "\"imidazolonepropionase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72769", "l": "7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+) => acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74958", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] <=> a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate => (S)-muconolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56316", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA = 3-acetylamino-4-hydroxybenzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21305", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46571", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004909", "l": "interleukin-1, type I, activating receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33028", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048248", "l": "CXCR3 chemokine receptor binding", "d": ["Binding to a CXCR3 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20582", "l": "H2O + NAD(+) + NH4(+) => 2 H(+) + hydroxylamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51251", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34969", "l": "sn-glycerol 3-phosphate(out) => sn-glycerol 3-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047807", "l": "cytokinin 7-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37997", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate => all-trans-nonaprenyl diphosphate + H(+) + homogentisate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0032027", "l": "myosin light chain binding", "d": ["Binding to a light chain of a myosin complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17180", "l": "(R)-carnitine + octanoyl-CoA <=> CoA + O-octanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24661", "l": "H(+) + L-arginine + NADPH + O2 => H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34425", "l": "(+)-lariciresinol + H(+) + NADPH => (-)-secoisolariciresinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51920", "l": "a quinone + AH2 = A + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11729", "l": "cyclopentanol + NAD(+) => cyclopentanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42826", "l": "H2O + 2 NAD(+) + tetracenomycin C => 2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71012", "l": "L-isoleucine(in) + L-phenylalanine(out) => L-isoleucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42695", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate <=> [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43495", "l": "7(1)-hydroxychlorophyll a + NADP(+) <=> chlorophyll b + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53795", "l": "benzylthiol + O2 <=> benzothialdehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55764", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68757", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804402", "l": "TP53 binds POU4F1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75841", "l": "H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in) => H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55368", "l": "(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428909", "l": "Activated TP receptor binds G-protein  G13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15127", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19206", "l": "dCTP + 2 H2O => diphosphate + dUMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43964", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202216", "l": "Phosphorylation of SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043741", "l": "alpha-aminoadipate acetyltransferase activity", "d": ["Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48584", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62721", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I => betaenone B + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981621", "l": "C3 convertases spontaneously dissociate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047189", "l": "2,3-diaminopropionate N-oxalyltransferase activity", "d": ["Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052680", "l": "epi-isozizaene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592239", "l": "Expression of PEO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.24", "l": "\"aminobenzoate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909732", "l": "Phosphorylation of STAT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35526", "l": "H(+) + N-ethylmaleimide + NADPH <=> N-ethylsuccinimide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49104", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204500", "l": "CyP60 chaperones Basigin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32411", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59126", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate => (S)-2,3-diaminopropanoate + ATP + citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62190", "l": "diphosphate + syn-isopimara-7,15-diene => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76537", "l": "FAD(out) => FAD(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694689", "l": "Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862084", "l": "PILRA,PILRB bind CD99 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694409", "l": "Nucleotide exchange on RAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37470", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976768", "l": "Factor H binds to C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33292", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251944", "l": "PLCG1 binds to p-ERBB2:p-EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008404", "l": "arachidonic acid 14,15-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid."], "t": []}, {"i": "RHEA:51472", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55228", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140823", "l": "histone H2BS36 kinase activity", "d": ["Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49127", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate <=> H2O + NADP(+) + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57814", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-2-nitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0019956", "l": "chemokine binding", "d": ["Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20313", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.158", "l": "\"inositol-pentakisphosphate 2-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14795", "l": "2-oxoadipate + H(+) + NADH => 2-hydroxyadipate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047216", "l": "inositol 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102262", "l": "tRNA-dihydrouridine16 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) = H+ + a uracil16 in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71969", "l": "(S)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (S)-2-hydroxyglutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50390", "l": "5a,11a-dehydrooxytetracycline + H2O + NADP(+) => 5a,11a-dehydrotetracycline + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163773", "l": "Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0047264", "l": "heteroglycan alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48558", "l": "4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate => 4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68836", "l": "(2Z,6E)-farnesyl diphosphate = (6R,7S)-himachala-9,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.9", "l": "\"(R)-2-haloacid dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354173", "l": "Activation of Rap1 by cytosolic GEFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036217", "l": "dGTP diphosphatase activity", "d": ["Catalysis of the reaction: dGTP + H2O = dGMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912727", "l": "CBL binds VAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15390", "l": "ATP => 3',5'-cyclic AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24739", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050619", "l": "phytochromobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729704", "l": "SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46930", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374173", "l": "AGT(34-41) binds to AGTR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759364", "l": "AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353516", "l": "Ligation of DNA at sites of patch replacement (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74817", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001097", "l": "TFIIH-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835121", "l": "Heparin binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392064", "l": "G alpha (z) inhibits adenylate cyclase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983150", "l": "Proteasomal cleavage of substrate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141439", "l": "Release of activated MAD2 from kinetochores (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61480", "l": "a sphingoid base + a very long-chain fatty acyl-CoA = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.297", "l": "\"very-long-chain ceramide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16653", "l": "D-gluconate + NADP(+) = 2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.215", "l": "\"gluconate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0015179", "l": "L-amino acid transmembrane transporter activity", "d": ["Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids."], "t": []}, {"i": "REACT:R-HSA-212614", "l": "Glutamine transport from astrocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38767", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.20", "l": "\"chondroitin-sulfate-ABC endolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390087", "l": "WTS binds to SAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052869", "l": "arachidonic acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173631", "l": "Activation of C1s (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14513", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.6", "l": "\"asparaginyl-tRNA synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14669", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003914", "l": "DNA (6-4) photolyase activity", "d": ["Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120226", "l": "succinyl-CoA binding", "d": ["Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49904", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164528", "l": "RNase H-mediated cleavage of the template strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875451", "l": "MET phosphorylates CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48579", "l": "4-chlorocatechol + O2 <=> 3-chloro-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090416", "l": "nicotinate transmembrane transporter activity", "d": ["Enables the transfer of nicotinate from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22857", "l": "(7S)-salutaridinol + acetyl-CoA => (7S)-O-acetylsalutaridinol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76816", "l": "D-alanine + H2O + NAD(+) => H(+) + NADH + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047948", "l": "glutarate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44349", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide B + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19405", "l": "acetyl-CoA + citrate = (3S)-citryl-CoA + acetate", "d": [], "t": []}, {"i": "EC:2.8.3.10", "l": "\"citrate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76887", "l": "5-hydroxypentan-2-amine + H2O + NAD(+) = 5-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950740", "l": "CANX dissociates from IL12A:EBI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77213", "l": "3alpha-sulfotaurodeoxycholate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + taurodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173740", "l": "Factor B binds to C3(H2O) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649108", "l": "HTR3A pentamer binds 5HT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16170", "l": "ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59867", "l": "(indol-3-yl)butanoate + ATP + L-glutamine <=> (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044014", "l": "histone H2BK5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26398", "l": "all-trans-zeaxanthin + 2 O2 => 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19083", "l": "a halide anion + a primary alcohol + H(+) => 1-haloalkane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53791", "l": "allodeoxycholoyl-CoA + beta-muricholate <=> allodeoxycholate + beta-muricholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63343", "l": "ATP + L-amino acyl-L-seryl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28347", "l": "7,8-dihydroneopterin 3'-triphosphate => 7,8-dihydromonapterin 3'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166015", "l": "Association of LBP with LPS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19958", "l": "2 5'-dehydroinosine + O2 => 2 9-riburonosylhypoxanthine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444691", "l": "Prokineticin receptors bind prokineticin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48065", "l": "a ganglioside GD1b (d18:1(4E)) + H2O => a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34246", "l": "GTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin guanine dinucleotide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64988", "l": "CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52343", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] <=> AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.52", "l": "\"diphosphoinositol-polyphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60302", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27836", "l": "a menaquinol + fumarate => a menaquinone + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168849", "l": "tBID binds to inactive BAX protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "72.868301077661471", "identifiers": [{"i": "GO:0046872", "l": "metal ion binding", "d": ["Binding to a metal ion."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30627", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26502", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55400", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) = archaeosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62018", "l": "3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64992", "l": "acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12808", "l": "(S)-canadine + S-adenosyl-L-methionine <=> (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60526", "l": "5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14605", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.36", "l": "\"alpha,alpha-trehalose-phosphate synthase (GDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22952", "l": "O2 + octanedioyl-CoA = (2E)-octenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25327", "l": "H(+) + phosphocholine + S-adenosyl-L-homocysteine => N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29687", "l": "alpha-maltoheptaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50760", "l": "a quinone + H2O + sulfite = a quinol + sulfate", "d": [], "t": []}, {"i": "EC:1.8.5.6", "l": "\"sulfite dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71821", "l": "L-thyroxine(in) => L-thyroxine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982017", "l": "Active G alpha (q) binds RGS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229343", "l": "AXIN is phosphorylated in the destruction complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047015", "l": "3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373074", "l": "Receptor CCR9  binds CCL25 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26070", "l": "CoA + H(+) + phosphinomethylmalate => 3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72717", "l": "diphosphate + N(6)-[(R)-dihydrolipoyl]-5'-AMP => (R)-dihydrolipoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35124", "l": "H(+)(out) + L-alanyl-D-glutamate(out) => H(+)(in) + L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190245", "l": "FGFR1b binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803892", "l": "SFN dimer binds BAX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043997", "l": "histone H4K12 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19053", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}, {"i": "EC:3.5.4.27", "l": "\"methenyltetrahydromethanopterin cyclohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45524", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": [], "t": []}, {"i": "EC:4.4.1.32", "l": "\"C-phycocyanin alpha-cysteine-84 phycocyanobilin lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166538", "l": "The bound receptor dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74166", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45613", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69107", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine <=> H2O + kynurenate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28980", "l": "H(+)(out) + nitrite(in) => H(+)(in) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374701", "l": "Phosphorylation of DCC by Fyn (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.62", "l": "\"glycosylceramidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.43", "l": "\"atroxase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49887", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30656", "l": "ATP + dUMP => ADP + dUDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015334", "l": "high-affinity oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813749", "l": "ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19714", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44807", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033729", "l": "anthocyanidin reductase activity", "d": ["Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53962", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444047", "l": "Receptor FFAR3 binds carboxylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12623", "l": "CO2 + L-alanine => H(+) + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:1901682", "l": "sulfur compound transmembrane transporter activity", "d": ["Enables the transfer of a sulfur compound from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34859", "l": "3-oxocyclopentanecarbonitrile + 2 H2O = 3-oxocyclopentanecarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15232", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70989", "l": "beta-alanine(in) + n H(+)(out) => beta-alanine(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46780", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.46", "l": "\"sn-1 linoleoyl-lipid 6-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60029", "l": "(2E)-geranyl diphosphate + H2O => 4-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30383", "l": "(2E,6E)-farnesyl diphosphate = (-)-7-epi-alpha-selinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.86", "l": "\"7-epi-alpha-selinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68603", "l": "ORC5 binds ORC2:ORC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13250", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204303", "l": "MRE11 binds cytosolic DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44341", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate => AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62757", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38842", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120298", "l": "peptide noradrenalinyltransferase activity", "d": ["Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)."], "t": []}, {"i": "RHEA:66560", "l": "(R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69703", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O = beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710254", "l": "GSDME oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018768", "l": "RHOU auto-activates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209278", "l": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11467", "l": "2 glutathione + L,L-homocystine <=> glutathione disulfide + 2 L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38482", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32937", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => a cardiolipin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17277", "l": "6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.12", "l": "\"phosphogluconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190245", "l": "FGFR1b binds to FGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26091", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4S)-limonene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65222", "l": "catechol + H(+) + NADPH => (1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60352", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 = CO + H(+) + N-octanoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57133", "l": "L-ascorbate + O2 + tyramine => (R)-octopamine + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67798", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34129", "l": "cannabigerolate + diphosphate => (2E)-geranyl diphosphate + olivetolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28308", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36504", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35044", "l": "N-(4-aminobenzoyl)-L-glutamate(in) => N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68037", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24980", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.97", "l": "\"3-hydroxy-4-methylanthranilate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76163", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2317332", "l": "PIP3 recruits AKT to the membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727188", "l": "ATP4A:ATP4B binds PPIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54983", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45139", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047479", "l": "trypanothione synthase activity", "d": ["Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45121", "l": "(4R)-ipsdienol + NAD(+) => H(+) + ipsdienone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62612", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64533", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23215", "l": "H2O + N-acetyl-beta-alanine <=> acetate + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42628", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.189", "l": "\"23S rRNA (uracil(747)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.16", "l": "\"vitamin D3 24-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851298", "l": "GPR143 binds L-Dopa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46453", "l": "2 L-leucyl-tRNA(Leu) => cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396009", "l": "STING binds c-di-GMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68992", "l": "3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 = 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.249", "l": "\"3-amino-4-hydroxybenzoate 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20819", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) <=> 3-oxoglycyrrhetinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74882", "l": "GNAT1-GDP binds to GNB1:GNGT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10847", "l": "oxaloacetate + pyridoxamine <=> L-aspartate + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609740", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3B (GRIN3B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69534", "l": "4-amino-4-deoxychorismate => (2S)-2-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51024", "l": "H(+) + NADH + O2 + toluene-4-sulfonate = 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30223", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide = 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": [], "t": []}, {"i": "EC:1.8.2.3", "l": "\"sulfide-cytochrome-c reductase (flavocytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0003954", "l": "NADH dehydrogenase activity", "d": ["Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor."], "t": []}, {"i": "RHEA:11356", "l": "A + H(+) + NADH = AH2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71022", "l": "L-phenylalanine(out) + L-valine(in) <=> L-phenylalanine(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165055", "l": "Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18447", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => H2O + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694442", "l": "CNIH2,3 bind GRIA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54883", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34363", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}, {"i": "EC:2.7.7.83", "l": "\"UDP-N-acetylgalactosamine diphosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351936", "l": "Caspase-mediated cleavage of claspin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31301", "l": "2 H(+) + NADH + perillate => H2O + NAD(+) + perillyl aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38907", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72596", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) => H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39195", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH = (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58015", "l": "cyclic tetraadenylate <=> 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.26", "l": "\"cancer procoagulant\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112392", "l": "Resumption of elongation after recovery from pausing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869580", "l": "DEK binds TFAP2A homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21221", "l": "L-dopa + O2 => 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15440", "l": "a long-chain fatty aldehyde + CoA + NADP(+) <=> a long-chain fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.4", "l": "\"phospholipase D\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40791", "l": "H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48868", "l": "H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25330", "l": "(R)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047569", "l": "3-oxoadipate CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75240", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392513", "l": "Rap1 signal termination by Rap1GAPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43189", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA => H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796071", "l": "NFE2L2 dependent NOTCH1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72262", "l": "L-dopa + S-adenosyl-L-methionine <=> 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686625", "l": "LAIR1 binds collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76272", "l": "N,N-dimethylglycine(in) => N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21491", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59024", "l": "H2O + trihexadecanoylglycerol = dihexadecanoylglycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61144", "l": "myricetin + UDP-beta-L-rhamnose = H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448741", "l": "IL22RA2 binds IL22 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052715", "l": "mannosyl-diinositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19115", "l": "(8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+) => (8Z,11Z,14Z)-heptadecatrienal + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632652", "l": "Hh-Npp binds CDON and PTCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.74", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187575", "l": "Ubiquitination of phospho-p27/p21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60962", "l": "(9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP => 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9689680", "l": "IFNG dimer binds IFNG inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847880", "l": "CYTH proteins bind ARF1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65518", "l": "NH4(+) + pre-mycofactocin => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34579", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D = 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.36", "l": "\"pentalenolactone F synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13481", "l": "ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)", "d": [], "t": []}, {"i": "EC:6.1.1.10", "l": "\"methionine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51783", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate <=> deoxyadlupulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41517", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61964", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.77", "l": "\"taurine--pyruvate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657651", "l": "MGMT binds alkylated DNA containing 6-O-methylguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203480", "l": "COLEC11 binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33744", "l": "an N-acylsphing-4-enine 1-phosphate + H2O => an N-acylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34384", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781897", "l": "USP11 deubiquitinates NFKBIA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0120017", "l": "ceramide transfer activity", "d": ["Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9675026", "l": "Formation of the MLL1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42994", "l": "(R)-nephthenol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607023", "l": "factor IXa associates with cell membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42407", "l": "H2O + lactose 6-phosphate <=> beta-D-glucose + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42296", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.n4", "l": "\"1-acyl-sn-glycerol-3-phosphate acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21353", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018451", "l": "epoxide dehydrogenase activity", "d": ["Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13883", "l": "a carboxylate + a quinol + H(+) => a quinone + an aldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33247", "l": "O2 + putrescine = 1-pyrroline + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193695", "l": "IRAK interacts with TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34610", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine <=> a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26005", "l": "D-arabinitol 1-phosphate + NAD(+) <=> D-xylulose 5-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59042", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.47", "l": "\"horrilysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61158", "l": "CoA + GDP + H(+) => 3'-dephospho-CoA + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52152", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23013", "l": "a fatty acid + S-adenosyl-L-methionine => a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432010", "l": "Aquaporin-1 passively transports water into cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12078", "l": "an aromatic aldehyde + H(+) + NADH => an aromatic primary alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54145", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 => 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74570", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) <=> L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48981", "l": "3,4-dichlorocatechol + O2 => (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061751", "l": "neutral sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850997", "l": "TRIM27 binds PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54398", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0019903", "l": "protein phosphatase binding", "d": ["Binding to a protein phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59856", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium = methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": [], "t": []}, {"i": "EC:2.1.1.252", "l": "\"tetramethylammonium--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59895", "l": "L-2-amino-4-chloropent-4-enoate <=> chloride + H(+) + L-propargylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18090", "l": "H2O + L-arginyl-[protein] => L-citrullyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15936", "l": "(S)-propane-1,2-diol + NAD(+) <=> (S)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052844", "l": "inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247849", "l": "WLS dissociates from retromer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69918", "l": "guanosine(out) + 2 Na(+)(out) <=> guanosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29360", "l": "H2O + UMP => phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19839", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-sorbitol 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49752", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NAD(+) + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47702", "l": "H2O + iso-precytochalasin + NADP(+) => H(+) + ketocytochalasin + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853762", "l": "RET dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047062", "l": "trans-acenaphthene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP+ = acenaphthene-1,2-dione + 2 H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31309", "l": "a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666001", "l": "Profilin:G-actin binds MKL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70584", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109857", "l": "MAP2K1 binds MAPK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22293", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA => biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983700", "l": "SYK binds the activated BCR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050383", "l": "uracil dehydrogenase activity", "d": ["Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033823", "l": "procollagen glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982775", "l": "Growth hormone receptor dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51003", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine <=> [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952419", "l": "SMURFs ubiquitinate RUNX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612501", "l": "SGK phosphorylates CREB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004490", "l": "methylglutaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17764", "l": "an aromatic primary alcohol + NADP(+) <=> an aromatic aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043027", "l": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "d": ["Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649856", "l": "Oxidative damage to the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964619", "l": "PAK1 binds ARHGEF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474266", "l": "Formation of collagen fibrils (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22082", "l": "H2O + NAD(+) + quinoline-2,8-diol => H(+) + NADH + O2 + quinolin-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48936", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156907", "l": "Aminoacyl-tRNA  binds to the ribosome at the A-site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42178", "l": "(9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68160", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40138", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> (9Z)-tetradecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27328", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75145", "l": "solanapyrone D => prosolanapyrone III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879221", "l": "PSTPIP1 binds Pyrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805479", "l": "TP53RK phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448702", "l": "Caspase-1 active tetramer formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64393", "l": "a dipeptide(out) + H(+)(out) => a dipeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140211", "l": "folic acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid."], "t": []}, {"i": "TCDB:2.A.1.50.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19666", "l": "6-carboxyhexanoyl-CoA + NAD(+) => 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12901", "l": "D-arginine + H2O = D-ornithine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.10", "l": "\"D-arginase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17076", "l": "acetyl-CoA + cortisol <=> CoA + cortisol 21-acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57782", "l": "3-chloro-4-methylcatechol + NAD(+) + nitrite => 2-chloro-4-nitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67160", "l": "chloride + FADH2 + melleolide F + O2 = 6'-chloromelleolide F + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2250301", "l": "Formation of lysyl-pyrrole cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29378", "l": "AMP + H2O <=> adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15678", "l": "5-aminopentanamide + H2O => 5-aminopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59677", "l": "D-maltotetraose + O2 => D-maltotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37357", "l": "phosphate + uridine => H2O + uridine 2'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68714", "l": "(1S,2S,4R)-beta-elemene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-593685", "l": "Netrin-4 binds DCC/UNC5A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784204", "l": "JAKs bind OSMR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44482", "l": "3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591052", "l": "PROCR binds Protein C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043754", "l": "dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity", "d": ["Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51171", "l": "(R)-adrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803719", "l": "TP53 binds ZNF385A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964274", "l": "G alpha (12) binds BTK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3221982", "l": "BANP binds TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65644", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.-", "l": "\"Ether hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2423785", "l": "CR:atREs binds apoE and HSPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000433", "l": "SUMOylation of PML with SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307802", "l": "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56290", "l": "H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709547", "l": "ESTG binds ESR2:chaperone complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40150", "l": "eicosanoyl-CoA + H2O <=> CoA + eicosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296233", "l": "T2Rs bind bitter-tasting compounds (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73803", "l": "dimethylallyl diphosphate + neoechinulin B = diphosphate + isoechinulin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62445", "l": "L-canavanine + L-ornithine => H(+) + L-arginine + L-canaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30686", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-D-mannosamine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54328", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH = hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047107", "l": "gamma-guanidinobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-guanidinobutanal + H2O + NAD+ = 4-guanidinobutanoate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909729", "l": "Activation of JAK kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41026", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21618", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050614", "l": "delta24-sterol reductase activity", "d": ["Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35371", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684238", "l": "E and N are recruited to the M lattice (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11917", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) => 15-oxoprostaglandin E2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21777", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42341", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31780", "l": "an all-trans-retinyl ester + H2O => 13-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220971", "l": "CDK8 phosphorylates NICD1 PEST domain mutants  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45442", "l": "H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47316", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37968", "l": "galactitol + NADP(+) => D-galactose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58511", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O <=> (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36850", "l": "FAD + L-threonyl-[protein] <=> AMP + FMN-L-threonyl-[protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.16", "l": "\"succinate-semialdehyde dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55224", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40600", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13326", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71776", "l": "acetoacetate(out) + H(+)(out) => acetoacetate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14974", "l": "L-aspartate => D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167942", "l": "Collagen type XIII ectodomain shedding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37369", "l": "2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10440", "l": "D-glucono-1,5-lactone + H2O = D-gluconate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.17", "l": "\"gluconolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106237", "l": "arachidonate 12(R)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate."], "t": []}, {"i": "RHEA:41336", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31968", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55320", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34938", "l": "2 ATP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983138", "l": "Transport of MHC heterotrimer to ER exit site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59497", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66938", "l": "avenanthramide C + CoA => (E)-caffeoyl-CoA + 5-hydroxyanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31776", "l": "all-trans-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12261", "l": "ATP + NADH => ADP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665701", "l": "Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76511", "l": "5-deoxystrigol + H2O = 5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65303", "l": "2-oxoglutarate + chrodrimanin C + O2 <=> CO2 + H2O + succinate + verruculide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53658", "l": "(5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate => (5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77721", "l": "a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27617", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate <=> di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879221", "l": "PSTPIP1 binds Pyrin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852317", "l": "PLK1 phosphorylates GTSE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13071", "l": "ADP + H(+) + phosphoethanolamine => ATP + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694662", "l": "Protein 3a forms a homotetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196026", "l": "Dab2 is recruited to the junctional plaques (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73637", "l": "CTP(in) + dGMP(out) => CTP(out) + dGMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29112", "l": "H(+) + NADPH + ubiquinone-8 => NADP(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49284", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.90", "l": "\"8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30831", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018538", "l": "epoxide carboxylase activity", "d": ["Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35788", "l": "paromamine + UDP-alpha-D-kanosamine => H(+) + kanamycin C + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40846", "l": "FAD + H(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696670", "l": "CHD1L is recruited to GG-NER site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75659", "l": "(11Z,14Z)-eicosadienoate + O2 = 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64488", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA = 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46052", "l": "a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398185", "l": "LARG binds plexin B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686930", "l": "RIPK3 is cleaved by CASP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47033", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA => 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42639", "l": "AH2 + L-cysteine + Mo-molybdopterin <=> A + H2O + L-alanine + thio-Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29963", "l": "H(+)(in) + inosine(in) = H(+)(out) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19895", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55038", "l": "an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N,N-dimethylornithine lipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875374", "l": "MET binds LRIG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77666", "l": "1-O-alkyl-3-acylglycerol + an acyl-CoA <=> 1-O-alkyl-2,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928591", "l": "EPH:EFN tetramers oligomerise (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11707", "l": "2 H(+) + N-(carboxyaminomethyl)urea <=> CO2 + N-(aminomethyl)urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28493", "l": "H(+)(in) + K(+)(in) <=> H(+)(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71645", "l": "H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide => guanosine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614933", "l": "ACEIs bind ACE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13884", "l": "a quinone + an aldehyde + H2O <=> a carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684096", "l": "CDK2 phosphorylates RBBP8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005129", "l": "granulocyte macrophage colony-stimulating factor receptor binding", "d": ["Binding to a granulocyte macrophage colony-stimulating factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18024", "l": "a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54330", "l": "hexadecan-1-ol + holo-[ACP] + 2 NADP(+) => 2 H(+) + hexadecanoyl-[ACP] + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047644", "l": "alizarin 2-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683831", "l": "CCDC59 binds TTF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14553", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C", "d": [], "t": []}, {"i": "EC:2.6.1.74", "l": "\"cephalosporin-C transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10458", "l": "1-O-acetylmaltose + CoA => acetyl-CoA + D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24702", "l": "NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": [], "t": []}, {"i": "EC:1.1.1.305", "l": "\"UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40195", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56226", "l": "3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27857", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64167", "l": "2-methyl-L-serine <=> formaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37078", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042085", "l": "5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62992", "l": "H2O + tetradecamide = NH4(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30111", "l": "Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}, {"i": "EC:3.1.1.108", "l": "\"iron(III) enterobactin esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32270", "l": "4-aminobutanoate + glyoxylate <=> glycine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9716913", "l": "ESR1 binds ESR1 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21649", "l": "H(+) + prephenate => 3-phenylpyruvate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0098531", "l": "ligand-activated transcription factor activity", "d": ["A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74198", "l": "aspulvinone E + O2 <=> (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873926", "l": "IFNG dimer binds IFNGR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156682", "l": "PLK1 phosphorylates NUDC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672980", "l": "Dissociation of RAS:RAF complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008684", "l": "TBK1 phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74675", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657775", "l": "Expression of ANGPTL3 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20883", "l": "10-hydroxydecanoate + NAD(+) <=> 10-oxodecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20236", "l": "a 7beta-hydroxysteroid + NADP(+) <=> a 7-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244647", "l": "cGAS binds cytosolic DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047512", "l": "(S,S)-butanediol dehydrogenase activity", "d": ["Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934465", "l": "SHC1 binds PTPN12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42113", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) => H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.76", "l": "\"arylalkyl acylamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32686", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 <=> 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905573", "l": "ganglioside GM1 binding", "d": ["Binding to ganglioside GM1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19552", "l": "H2O + o-orsellinate depside <=> H(+) + 2 orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65414", "l": "dAMP(out) + NAD(+)(in) => dAMP(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63572", "l": "H2O + neurotensin-(1-8) = L-arginine + neurotensin-(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102402", "l": "2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "d": ["Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26092", "l": "(4S)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140064", "l": "peptide crotonyltransferase activity", "d": ["Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide."], "t": []}, {"i": "RHEA:53908", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33768", "l": "a 3-hydroxy-fatty acyl-CoA => a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162657", "l": "Inactivation of Myt1 kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19372", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68949", "l": "esculetin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050634", "l": "phloroisovalerophenone synthase activity", "d": ["Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13383", "l": "a carboxylate + acetyl-CoA => acetate + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55931", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65693", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine => a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33192", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418082", "l": "Dissociation of telomerase RNP from the extended chromosomal end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700168", "l": "Active ALK phosphorylates IRS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14260", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034215", "l": "thiamine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55968", "l": "(+)-kolavelool + S-adenosyl-L-methionine = (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.347", "l": "\"(+)-O-methylkolavelool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004031", "l": "aldehyde oxidase activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012835", "l": "GDIs block activation of RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61041", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32511", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74398", "l": "2 (S)-lactate(in) + prostaglandin E1(out) <=> 2 (S)-lactate(out) + prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336182", "l": "GPR37 binds prosaptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70331", "l": "3-hydroxyphenylacetyl-CoA + H2O = 3-hydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769165", "l": "NPAS4 binds PLK2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25668", "l": "beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018690", "l": "4-methoxybenzoate monooxygenase (O-demethylating) activity", "d": ["Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56905", "l": "an acyl-AMP + CoA => AMP + an acyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196773", "l": "COASY phosphorylates DP-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762246", "l": "ANGPTL4 binds CDH11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52858", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141423", "l": "Binding of the MCC complex to the APC/C complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047803", "l": "cysteine lyase activity", "d": ["Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672011", "l": "p-AMPK:AMP binds the ULK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983421", "l": "Journey of cargo through Golgi complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033995", "l": "anhydrosialidase activity", "d": ["Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50617", "l": "NADP(+) + nonan-2-one => (3E)-nonen-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75128", "l": "neopinone => codeinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250616", "l": "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975594", "l": "PLB1 hydrolyses RPALM to atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31866", "l": "(S)-2,3-epoxysqualene <=> friedelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14564", "l": "(E,E)-piperoyl-CoA + piperidine <=> CoA + H(+) + piperine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603467", "l": "Activated protein C is released from PROCR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047616", "l": "acyl-CoA dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617676", "l": "HOXA3 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33677", "l": "H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212222", "l": "PRC2 recruits DNA methyltransferases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70333", "l": "3-hydroxyphenylacetate + CoA + H(+) => 3-hydroxyphenylacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23830", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625465", "l": "E2-mediated FOS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53592", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1-tetradecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193653", "l": "NGF homodimer binds to p75NTR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015493", "l": "lysine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48622", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11388", "l": "an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.146", "l": "\"11beta-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57103", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thio-D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804596", "l": "APAF1:CYCS binds APIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111966", "l": "GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38435", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046817", "l": "chemokine receptor antagonist activity", "d": ["Interacts with chemokine receptors to reduce the action of a chemokine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40629", "l": "2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64438", "l": "glycylglycyl-L-isoleucine(in) + H(+)(in) => glycylglycyl-L-isoleucine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514790", "l": "Elastin degradation by MMP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20240", "l": "(1S,4S)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030743", "l": "23S rRNA (adenosine(1067)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-844438", "l": "NLRP1 oligomerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800793", "l": "PIDD1 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102845", "l": "1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62761", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102244", "l": "3-aminopropanal dehydrogenase activity", "d": ["Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O = 2 H+ + beta-alanine + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814409", "l": "CK2 phosphorylates PDCL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875451", "l": "MET phosphorylates CBL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67575", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate <=> adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55079", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) <=> 3-methylsulfanylpropanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.17", "l": "\"nitric oxide dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835454", "l": "DNAJC3 binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41445", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 => glycine + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851908", "l": "Activated MET binds GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60710", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADH => (1R,3R)-chrysanthemal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31383", "l": "(S)-2,3-epoxysqualene = lupeol", "d": [], "t": []}, {"i": "EC:5.4.99.41", "l": "\"lupeol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70253", "l": "cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112434", "l": "Formation of DSIF complex  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56305", "l": "ATP + H2O + rifampicin => 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660665", "l": "Caspase-8 binds MALT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10048", "l": "methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47870", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => di-(9Z)-octadecenoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647680", "l": "CASP1 cleaves GSDMD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70357", "l": "biuret + CO2 => 1-carboxybiuret + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76494", "l": "POR reduces CYP450:Fe3+ to CYP450:Fe2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762333", "l": "ANGPTL4 binds to CDH11v (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20099", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-mannonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218820", "l": "Src kinases phosphorylate VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008828", "l": "dATP diphosphatase activity", "d": ["Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173115", "l": "Formation of Pre-Integration Complex (PIC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16374", "l": "(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60199", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25751", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70692", "l": "ornithine => putrescine + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70790", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) <=> H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15585", "l": "15-cis-phytoene + 4 A = 4 AH2 + all-trans-lycopene", "d": [], "t": []}, {"i": "EC:1.3.99.31", "l": "\"phytoene desaturase (lycopene-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18904", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine <=> benzyl alcohol + CO2 + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16361", "l": "2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45131", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983156", "l": "Polyubiquitination of substrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31038", "l": "arabidiol <=> (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26021", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399952", "l": "Phosphorylation of LIMK-1 by PAK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15302", "l": "D-apiitol + NAD(+) => aldehydo-D-apiose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50499", "l": "acetyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043793", "l": "beta-ribofuranosylaminobenzene 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76614", "l": "H(+) + NADPH + vanillin <=> 4-hydroxy-3-methoxy-benzenemethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54297", "l": "GTP + L-tyrosyl-[protein] => diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43063", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> beta-D-glucose 1-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24278", "l": "acetyl phosphate + phosphate => acetate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169192", "l": "PTP1B dephosphorylates GHR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25811", "l": "H2O + O2 + spermidine <=> 3-aminopropanal + H2O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692749", "l": "CDC14A,B bind MAPK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19828", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-aristolochene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.104", "l": "\"5-phospho-D-xylono-1,4-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14204", "l": "D-lyxose <=> D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31093", "l": "3-oxotetradecanoyl-CoA + CoA => acetyl-CoA + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382061", "l": "Extracellular processing of novel PDGFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41526", "l": "5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol => 5 H(+) + 5 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72631", "l": "Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68397", "l": "a percarboxylic acid + H2O => a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45038", "l": "3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392834", "l": "Activation of EPACs by cAMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44278", "l": "4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA => eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047445", "l": "3-hydroxy-3-isohexenylglutaryl-CoA lyase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H+ = 7-methyl-3-oxooct-6-enoyl-CoA + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71486", "l": "H2O + Met-enkephalin <=> L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19563", "l": "H2O + NADP(+) + testololactone => androst-4-ene-3,17-dione + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50316", "l": "ethyl octadecanoate + H2O = ethanol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46198", "l": "7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418845", "l": "Activation of caspase-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64236", "l": "atrochrysone carboxyl-[ACP] + H2O = atrochrysone carboxylate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53936", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482770", "l": "Release of platelet secretory granule components (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1006143", "l": "CD46 binds C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17686", "l": "H(+) + uracil 5-carboxylate => CO2 + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69655", "l": "H2O + quercetin 3-O-beta-D-glucoside = beta-D-glucose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46887", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62523", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10906", "l": "AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide => [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419011", "l": "Transhomodimerization of Nectins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17691", "l": "adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659820", "l": "RB1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3782637", "l": "HDAC8 deacetylates histones (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61987", "l": "H(+) + NADH + ubiquinone-10 <=> NAD(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10312", "l": "H(+) + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.15", "l": "\"terephthalate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849908", "l": "SALM4 binds flotillin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018111", "l": "methionine racemase activity", "d": ["Catalysis of the reaction: L-methionine = D-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68611", "l": "Formation of ORC(1-5) complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004878", "l": "complement component C5a receptor activity", "d": ["Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11056", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 = 4-aminophenol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:0015106", "l": "bicarbonate transmembrane transporter activity", "d": ["Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420883", "l": "Opsins act as GEFs for G alpha-t (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39657", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36372", "l": "(2S)-hydroxybutanoate + NAD(+) => 2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545253", "l": "Deacetylation of cohesin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297354", "l": "Acrosin Cleavage (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67786", "l": "1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66206", "l": "(2E)-heptenoyl-CoA + H2O2 => heptanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48357", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73729", "l": "Formation of SL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.124", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53680", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15350", "l": "L-glutamate + N(2)-acetyl-L-ornithine => L-ornithine + N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14158", "l": "H2O + triphosphate => diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22061", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58682", "l": "AH2 + FAD + H(+) => A + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578712", "l": "Importin-8 binds AGO2:miRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17131", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629918", "l": "NEIL1 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179421", "l": "Degradation of multiubiquitinated Nek2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102741", "l": "paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity", "d": ["Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine = H+ + caffeine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950766", "l": "IL27RA dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034452", "l": "dynactin binding", "d": ["Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69219", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) <=> (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56199", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69841", "l": "(22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102706", "l": "butein:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64065", "l": "(1R,2R)-pseudoephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48369", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73975", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31518", "l": "4'-apo-beta-carotenal + H2O + NAD(+) <=> 2 H(+) + NADH + neurosporaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12762", "l": "precorrin-3B + S-adenosyl-L-methionine => 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690461", "l": "FKBP1A binds tacrolimus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28750", "l": "NH4(+)(in) <=> NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37896", "l": "H2O + protodioscin => 26-deglucoprotodioscin + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047920", "l": "geissoschizine dehydrogenase activity", "d": ["Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49563", "l": "D-sedoheptulose 7-phosphate <=> (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34183", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30039", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 = benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25477", "l": "(2E,6E)-farnesyl diphosphate => alpha-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67508", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62508", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13379", "l": "ADP + alpha-D-glucose 1,6-bisphosphate + H(+) => alpha-D-glucose 1-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61435", "l": "(R)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47617", "l": "ethionamide + H(+) + NADPH + O2 => ethionamide S-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23245", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033520", "l": "TYSND1 cleaves TYSND1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59175", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509831", "l": "ITPA hydrolyses XTP to XMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39678", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28691", "l": "(S)-dihydroorotate + a ubiquinone = a ubiquinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797974", "l": "LRRTMs bind NRXNs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57052", "l": "3-oxoisoapionate + H(+) = CO2 + L-erythrulose", "d": [], "t": []}, {"i": "EC:4.1.1.120", "l": "\"3-oxoisoapionate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41666", "l": "chelirubine + NADH => dihydrochelirubine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28069", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) <=> alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806629", "l": "Formation of tonofilament bundles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605717", "l": "GM2A binds and mobilizes ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72591", "l": "D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614591", "l": "Excess cysteine yields lanthionine and H2S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24068", "l": "cyclohexanone + H(+) + NADPH + O2 = H2O + hexano-6-lactone + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.22", "l": "\"cyclohexanone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005150", "l": "interleukin-1, type I receptor binding", "d": ["Binding to a Type I interleukin-1 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47152", "l": "2,5-dioxopentanoate + H2O + NAD(+) = 2-oxoglutarate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799332", "l": "ATR phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624120", "l": "CEBPA binds CDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797196", "l": "AP-1 transcription factor binds IGFBP7 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362522", "l": "ALDHs oxidise atRAL to atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68730", "l": "3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59455", "l": "a long-chain primary fatty alcohol + NADP(+) <=> a long-chain fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071518", "l": "autoinducer-2 kinase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31842", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22349", "l": "4-aminoimidazole + H(+) + H2O => imidazol-4-one + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64611", "l": "L-threonyl-[protein] + UTP <=> diphosphate + uridylyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050055", "l": "limonin-D-ring-lactonase activity", "d": ["Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785438", "l": "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008876", "l": "quinoprotein glucose dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59880", "l": "4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13722", "l": "H2O + testololactone => H(+) + testolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.4", "l": "\"Gly-Xaa carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62890", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+) => GDP-beta-L-fucose + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65302", "l": "CO2 + H2O + succinate + verruculide A => 2-oxoglutarate + chrodrimanin C + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24067", "l": "2 5-aminolevulinate <=> H(+) + 2 H2O + porphobilinogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652277", "l": "ERBB2 binds trastuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35193", "l": "H2O + norsolorinic acid => noranthrone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72444", "l": "(E)-feruloyl-AMP + CoA => (E)-feruloyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014456", "l": "GDIs block activation of RHOG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657665", "l": "ALKBH2 binds alkylated dsDNA containing 3-meC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38887", "l": "H2O + N-hexanoyl-sphinganine = hexanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76800", "l": "(2S)-2-aminobutan-1-ol + H2O + NAD(+) => 1-hydroxy-2-butanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21497", "l": "dimethylallyl diphosphate + H2O => diphosphate + prenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964759", "l": "Alternative endo-mannosidase I route (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49589", "l": "L-erythrulose 1-phosphate => D-erythrulose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483238", "l": "Hh processing variants are ubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28239", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052810", "l": "1-phosphatidylinositol-5-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36815", "l": "dTDP-alpha-D-fucose = dTDP-alpha-D-fucofuranose", "d": [], "t": []}, {"i": "EC:5.4.99.59", "l": "\"dTDP-fucopyranose mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11955", "l": "3-hydroxypyruvate <=> 2-hydroxy-3-oxopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59811", "l": "L-tyrosine <=> D-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31088", "l": "acetyl-CoA + octanoyl-CoA => 3-oxodecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74118", "l": "an anthocyanidin + UDP-alpha-D-galactose <=> an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59422", "l": "formaldehyde + H2O2 + NH4(+) => H2O + methylamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30072", "l": "acetyl-CoA + butanoate => acetate + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41627", "l": "3-sulfinopropanoyl-CoA + H2O <=> H(+) + propanoyl-CoA + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953037", "l": "E2F8 forms homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371467", "l": "SIRT1 deacetylates HSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165680", "l": "Formation of active mTORC1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70709", "l": "6-sulfo-D-rhamnose => 6-sulfo-beta-D-quinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803999", "l": "HNO2 produces N2O3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19568", "l": "(2E)-geranyl diphosphate + H2O <=> diphosphate + sabinene hydrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227783", "l": "Phosphorylation of IKKs complex mediated by MEKK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299359", "l": "Activation of TALK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19554", "l": "H2O + L-tryptophan => indole + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72077", "l": "ADP + H(+) + ophthalmate + phosphate => ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32136", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40961", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57592", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68030", "l": "H2O2 + urate => 6,8-dihydroxypurine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70481", "l": "TPI1 isomerizes GA3P to DHAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57016", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13126", "l": "CoA + glutathione disulfide => CoA-glutathione + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047303", "l": "glycine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58088", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O = (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665871", "l": "ADRM1 binds 26S proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16314", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61096", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102414", "l": "quercetin-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) = quercetin-3-gentiobioside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244506", "l": "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944250", "l": "Association of procollagen type XXV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18703", "l": "arsenate + 3 H(+) + 2 reduced [azurin] => arsenite + H2O + 2 oxidized [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253343", "l": "WWOX binds ERBB4s80 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856157", "l": "LAG3 (CD233) binds MHC II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357483", "l": "RAC1 binds PAK1-3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77094", "l": "Formation of cap binding complex (CBC) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004938", "l": "alpha2-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29517", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613644", "l": "SOX10-dependent POU3F1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047286", "l": "NAD+-diphthamide ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015213", "l": "uridine transmembrane transporter activity", "d": ["Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179291", "l": "UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26531", "l": "4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15206", "l": "a dolichyl diphosphooligosaccharide + H2O => a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003983", "l": "UTP:glucose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76742", "l": "dodecane + O2 + reduced [NADPH--hemoprotein reductase] <=> 5-dodecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097626", "l": "low-affinity L-arginine transmembrane transporter activity", "d": ["Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51779", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate <=> deoxycohumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58929", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol => (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64125", "l": "H2O + N-hexadecanoyl-L-phenylalanine => hexadecanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73509", "l": "7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799097", "l": "ATM phosphorylates ZNF420 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72530", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57256", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26452", "l": "H(+) + NADPH + succinyl-CoA => CoA + NADP(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73698", "l": "dADP(out) + H(+)(out) + phosphate(in) <=> dADP(in) + H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759141", "l": "AcK-NFE2L2 and MAFK bind NQO1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19808", "l": "a purine D-ribonucleoside + phosphate <=> a purine nucleobase + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0019789", "l": "SUMO transferase activity", "d": ["Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57104", "l": "[(1->4)-alpha-D-galacturonosyl](n) = 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": [], "t": []}, {"i": "EC:4.2.2.9", "l": "\"pectate disaccharide-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.68", "l": "\"t-plasminogen activator\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61033", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine => 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684071", "l": "RNF4 ubiquitinates MDC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20429", "l": "apigenin + S-adenosyl-L-methionine = acacetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.75", "l": "\"apigenin 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102807", "l": "cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine = cyanidin 3-O-sophoroside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004425", "l": "indole-3-glycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613210", "l": "EGR1, EGR2 bind the RRAD promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602458", "l": "Activation of proMMP10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390909", "l": "HRH2 binds hist (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20366", "l": "phosphoethanolamine + S-adenosyl-L-methionine => H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32285", "l": "H(+) + H2O + quinolinate => 3-hydroxyanthranilate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49925", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37031", "l": "D-ribonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33956", "l": "DIBOA + UDP-alpha-D-glucose => DIBOA beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005006", "l": "epidermal growth factor receptor activity", "d": ["Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74299", "l": "D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032567", "l": "dGTP binding", "d": ["Binding to dGTP, deoxyguanosine triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11286", "l": "H(+) + NADH + oxomalonate => hydroxymalonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n6", "l": "\"hexahomomethionine N-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14842", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56347", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose <=> a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015475", "l": "adhesin autotransporter activity", "d": ["Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40593", "l": "CoA + decanedioate + H(+) => decanedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201717", "l": "CSNK2-mediated phosphorylation of DVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65034", "l": "3 a quinol + protoporphyrin IX => 3 a quinone + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40422", "l": "H2O + phytanoyl-CoA <=> 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26522", "l": "(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.117", "l": "\"2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75740", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH => 10-oxooctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202137", "l": "AKT1 binds eNOS complex via HSP90 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74947", "l": "p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603108", "l": "Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18291", "l": "H2O + oxaloacetate => (S,S)-tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607737", "l": "BCL10 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30119", "l": "dodecanoyl-[ACP] + H2O = dodecanoate + H(+) + holo-[ACP]", "d": [], "t": []}, {"i": "EC:3.1.2.21", "l": "\"dodecanoyl-[acyl-carrier-protein] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77703", "l": "a ganglioside GA1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GA1 (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50943", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) <=> cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16284", "l": "ATP + dihydrostreptomycin 6-phosphate <=> ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42476", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20018", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 => 5,10-methylenetetrahydromethanopterin + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950504", "l": "IL27 binds CRLF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.174", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.64", "l": "\"peptidase K\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69499", "l": "decan-1-ol + O2 <=> decanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120091", "l": "jasmonic acid hydrolase", "d": ["Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015068", "l": "glycine amidinotransferase activity", "d": ["Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693608", "l": "Initial resection of double-strand break ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24633", "l": "2 H2O + 3 NADP(+) + NH4(+) => 5 H(+) + 3 NADPH + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53868", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate = 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45267", "l": "(9Z,12Z)-octadecadienoate(out) <=> (9Z,12Z)-octadecadienoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45550", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15804", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610723", "l": "GLI proteins bind SUFU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69333", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) => 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162840", "l": "Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15034", "l": "O2 + pyridoxine => H2O2 + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867041", "l": "EGFR phosphorylates EPS15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17700", "l": "pyridine + thiamine <=> 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32567", "l": "(2E)-geranyl diphosphate = (1R,4S)-camphene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.116", "l": "\"(+)-camphene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62016", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.63", "l": "\"EGF-domain serine xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013109", "l": "RHOC GEFs activate RHOC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38011", "l": "chlorophyll a + H2O = chlorophyllide a + H(+) + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64528", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20438", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876472", "l": "NPC2 binds CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.34", "l": "\"2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807077", "l": "NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22185", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) => acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20788", "l": "NAD(+) + phosphate = ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030023", "l": "extracellular matrix constituent conferring elasticity", "d": ["A component of the extracellular matrix that enables the matrix to recoil after transient stretching."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30202", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59585", "l": "ATP + beta-alanine + L-lysine => ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726621", "l": "PGR binds PGR antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56688", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.9", "l": "\"tyrosine isonitrile desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710468", "l": "GSDME variant does not bind PIPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34002", "l": "zymosterol <=> 5alpha-cholesta-7,24-dien-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73241", "l": "H(+) + ladanein + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63739", "l": "2-phenylacetaldehyde + H(+) + NADPH <=> 2-phenylethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66695", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] <=> dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54742", "l": "19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41631", "l": "geranylgeranyl diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65717", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 => an aldehyde + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420131", "l": "The PACAP receptor binds PACAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804762", "l": "TP53 forms homotetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11984", "l": "AH2 + O2 + progesterone = A + H2O + testosterone acetate", "d": [], "t": []}, {"i": "EC:1.14.99.4", "l": "\"progesterone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72093", "l": "(R)-carnitine(in) + Na(+)(in) => (R)-carnitine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25632", "l": "myricetin + S-adenosyl-L-methionine <=> H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937097", "l": "MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981931", "l": "RAC1 and CDC42 activate PAK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.6", "l": "\"tubulin GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56015", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398185", "l": "LARG binds plexin B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30605", "l": "AH2 + all-trans-phytofluene => 15-cis-phytoene + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.123", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800298", "l": "HGF dimer binds MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33878", "l": "cholesteryl (9Z-octadecenoate) + H2O <=> (9Z)-octadecenoate + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53792", "l": "benzylthiol + O2 = benzothialdehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836227", "l": "RSV F binds TLR4:LY96:CD14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74608", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) => UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.115", "l": "\"infectious pancreatic necrosis birnavirus Vp4 peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395992", "l": "p-T,4S-IRF3 is dimerized (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56494", "l": "gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => hederagenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71896", "l": "dGTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047960", "l": "glycine dehydrogenase activity", "d": ["Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047975", "l": "guanosine phosphorylase activity", "d": ["Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798748", "l": "Exocytosis of secretory granule lumen proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28890", "l": "H(+)(in) + L-serine(in) <=> H(+)(out) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430158", "l": "p-SLP-76 binds VAV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23011", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694373", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669158", "l": "NF2 binds PAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9833635", "l": "p-PKR dimer localizes to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22265", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 => 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59027", "l": "H2O + trihexadecanoylglycerol <=> dihexadecanoylglycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19834", "l": "(6R)-10-formyltetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727349", "l": "XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10155", "l": "ATP + hydrogencarbonate + NH4(+) <=> ADP + carbamoyl phosphate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0001099", "l": "basal RNA polymerase II transcription machinery binding", "d": ["Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19608", "l": "a chlorophyll + H2O <=> a chlorophyllide + H(+) + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36211", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449855", "l": "IL10 dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77081", "l": "Formation of the CE:GMP intermediate complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44904", "l": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32184", "l": "cholesterol + O2 => cholest-5-en-3-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004485", "l": "methylcrotonoyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13128", "l": "CoA + glutathione disulfide <=> CoA-glutathione + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620915", "l": "BTG1 gene expression is stimulated by FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450975", "l": "isocitrate <=> citrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19533", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.23", "l": "\"N-succinylarginine dihydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:1904399", "l": "heparan sulfate binding", "d": ["Binding to heparan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917696", "l": "Cargo Sequestration (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31472", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32292", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine => 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40867", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) = (2E,9E)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73545", "l": "dCDP(in) + UTP(out) => dCDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55842", "l": "calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102303", "l": "resveratrol 3,5-O-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26327", "l": "(8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine => (8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11416", "l": "2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": [], "t": []}, {"i": "EC:2.3.1.90", "l": "\"beta-glucogallin O-galloyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23613", "l": "1,2-dihydro-alpha-santonin + NAD(+) => alpha-santonin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.2", "l": "\"bacteriochlorophyllide c C-7(1)-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14856", "l": "4-chlorobenzoyl-CoA + H2O <=> 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050782", "l": "galactose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008043", "l": "MAPK8 phosphorylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686625", "l": "LAIR1 binds collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.731030655927583", "identifiers": [{"i": "GO:0016813", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2."], "t": []}, {"i": "EC:3.5.3.-", "l": "\"In linear amidines\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.20", "l": "\"aminopeptidase Ey\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592278", "l": "Autocatalytic activation of proMMP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56891", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose <=> UDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665989", "l": "DIAPH1 binds RHOA:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014433", "l": "RHOG GEFs activate RHOG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77077", "l": "Capping complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52566", "l": "3-dehydro-L-erythronate => 2-dehydro-L-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.91", "l": "\"7-methylguanosine nucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433711", "l": "Cis-homodimerization of nectins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53583", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24014", "l": "(+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine => gamma-tocopherol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250217", "l": "ARL2:GTP binds ARL2BP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42305", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8979071", "l": "KDM6B binds iron (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448963", "l": "Interaction of MyoD:E protein with MEF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997381", "l": "TDPK phosphorylates ThDP to ThTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009072", "l": "STAT3 phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682026", "l": "MRN bound to shortened telomeres activates ATM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76049", "l": "(S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine => (S)-tetrahydropalmatine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685953", "l": "SIRT6 deacetylates RBBP8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102143", "l": "carboxynorspermidine dehydrogenase I activity", "d": ["Catalysis of the reaction: carboxynorspermidine + NADP + H2O = L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204850", "l": "Interaction of Tie2 and Dok-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57740", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) = a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.118", "l": "\"meromycolic acid enoyl-[acyl-carrier-protein] reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140951", "l": "histone H3K27 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036289", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47595", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GP1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14083", "l": "D-glyceraldehyde 3-phosphate + indole => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53014", "l": "chloride + chlorohydroquinone + glutathione disulfide + H(+) => 2,5-dichlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56270", "l": "CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66742", "l": "ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30988", "l": "(S)-2,3-epoxysqualene => (17Z)-protosta-17(20),24-dien-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318576", "l": "Defective MMACHC does not reduce Cbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48184", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12444", "l": "hexadecanal + NADP(+) = (2E)-hexadecenal + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.27", "l": "\"2-hexadecenal reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35470", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042974", "l": "nuclear retinoic acid receptor binding", "d": ["Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36981", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53569", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22080", "l": "H(+) + NADH + O2 + quinolin-2-ol = H2O + NAD(+) + quinoline-2,8-diol", "d": [], "t": []}, {"i": "EC:1.14.13.61", "l": "\"2-hydroxyquinoline 8-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047020", "l": "15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031704", "l": "apelin receptor binding", "d": ["Binding to an apelin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25730", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610723", "l": "GLI proteins bind SUFU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30197", "l": "9,9',15-tri-cis-zeta-carotene + plastoquinol-9 => 15,9'-di-cis-phytofluene + plastoquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25523", "l": "an acyl-CoA + pseudotropine <=> CoA + H(+) + O-acylpseudotropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51830", "l": "AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + docosanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74847", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP = 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65371", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17912", "l": "(S)-lactate <=> acetaldehyde + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45949", "l": "acetyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654159", "l": "Activated FGFR2 binds PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047169", "l": "galactarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016438", "l": "tRNA-queuosine(34) beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + queuosine34 in tRNA(Asp) = GDP + H+ + O-4''-alpha-D-mannosylqueuosine34 in tRNA(Asp)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784598", "l": "NPPA(124-151) binds NPR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43828", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68960", "l": "DNA polymerase epsilon binds at the origin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50900", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76915", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NADP(+) = 3-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662096", "l": "Exocytosis of glutamate from cochlear inner hair cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37756", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388831", "l": "Phosphorylation of CD28 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811479", "l": "ING2 recruits EP300 to TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417820", "l": "P2Y9 receptor can bind to LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61613", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => 7-epi-cylindrospermopsin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615945", "l": "RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68543", "l": "(2Z,6Z)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749494", "l": "IKBIP binds IKBKB and CHUK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64371", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652816", "l": "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20213", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}, {"i": "EC:2.3.1.204", "l": "\"octanoyl-[GcvH]:protein N-octanoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52170", "l": "8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21050", "l": "ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate => ATP + isopropylamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72979", "l": "didemethylasterriquinone D + dimethylallyl diphosphate = asterriquinone C1 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45008", "l": "H2O + N-(octadecanoyl)-sphinganine = octadecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15892", "l": "H2O + L-glutamine <=> L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53213", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52503", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987007", "l": "p-STAT1 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213466", "l": "RIPK3 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60177", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O => 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30790", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654569", "l": "Activated FGFR1 binds FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43515", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 <=> 2-carboxy-5-formylfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58491", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 <=> H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018855", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity", "d": ["Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77672", "l": "a globoside GalGb4Cer (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a globoside MSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61764", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside E + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17593", "l": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine", "d": [], "t": []}, {"i": "EC:2.6.1.64", "l": "\"glutamine--phenylpyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19285", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol = a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": [], "t": []}, {"i": "EC:2.3.1.83", "l": "\"phosphatidylcholine--dolichol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13916", "l": "L-threonine <=> D-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31467", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-glucosyl) crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39438", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57297", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13015", "l": "an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51431", "l": "acetyl-CoA + aminomethylphosphonate <=> 2-N-acetamidomethylphosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052588", "l": "diacetyl reductase ((S)-acetoin forming) activity", "d": ["Catalysis of the reaction: (S)-acetoin + NAD+ = diacetyl + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73197", "l": "malonate(out) + sulfate(in) => malonate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005360", "l": "insulin-responsive glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660752", "l": "USP9X deubiquitinates Ub-SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67682", "l": "a long-chain fatty acid + CoA + H(+) => a long-chain fatty acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63986", "l": "5-hydroxyuridine 5'-phosphate + ADP + H(+) => 5-hydroxyuridine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23105", "l": "D-arabinose 5-phosphate => D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211247", "l": "Cleavage of DNA by DFF40 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018477", "l": "benzaldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74950", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 <=> (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56376", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25406", "l": "(R)-3-hydroxy-3-methyl-2-oxopentanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47604", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1calpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30481", "l": "2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77485", "l": "(2S)-2-hydroxy-2-methylheptanenitrile => heptan-2-one + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36081", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41510", "l": "H2O + N(5)-hydroxy-L-ornithine + NADP(+) => L-ornithine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018786", "l": "haloalkane dehalogenase activity", "d": ["Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731077", "l": "SARS-CoV-1 8b binds to IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51303", "l": "(9Z)-octadecenoate + L-phenylalanine <=> H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44838", "l": "a globoside NOR2 (d18:1(4E)) + H(+) + UDP => a globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660980", "l": "p-S276-RELA binds RELB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785704", "l": "DSB inducing agents induce double strand DNA breaks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61948", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036461", "l": "BLOC-2 complex binding", "d": ["Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15932", "l": "2 H(+) + 2 H2O + methylenediurea <=> CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212614", "l": "Glutamine transport from astrocytes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76947", "l": "3-methyl-2-aminobutane + H2O + NADP(+) = 3-methylbutan-2-one + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205244", "l": "Recruitment of CBL to KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53705", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O => H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57131", "l": "H2O + 2 oxidized [azurin] + tyramine <=> (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70056", "l": "AH2 + cremeomycin => 2-hydroxy-4-methoxybenzoate + A + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65021", "l": "L-ornithine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77543", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13473", "l": "H2O + L-tryptophan + NAD(+) = H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43452", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11183", "l": "ATP + L-asparagine + tRNA(Asn) <=> AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11175", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine <=> (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047641", "l": "aldose-6-phosphate reductase (NADPH) activity", "d": ["Catalysis of the reaction: D-glucitol 6-phosphate + NADP+ = D-glucose 6-phosphate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34497", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70236", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381727", "l": "RAP1A exchanges GDP for GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11780", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.134", "l": "\"galactosylxylosylprotein 3-beta-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50845", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40986", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42421", "l": "2-oxoglutarate + L-lysine + O2 => (4R)-4-hydroxy-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17765", "l": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)", "d": [], "t": []}, {"i": "EC:5.4.2.4", "l": "\"bisphosphoglycerate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.89", "l": "\"4'-methoxyisoflavone 2'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14331", "l": "3-phosphooxypyruvate + L-glutamate => 2-oxoglutarate + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693536", "l": "ATM phosphorylates MDC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24671", "l": "H2O + hypoxanthine + NAD(+) => H(+) + NADH + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166726", "l": "Activation of MASPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74440", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0010853", "l": "cyclase activator activity", "d": ["Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39839", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013159", "l": "CDC42 GEFs activate CDC42 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693250", "l": "RHOD binds effectors at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53346", "l": "H(+) + NADPH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34792", "l": "2-hydroxyethylphosphonate + O2 => formate + H(+) + hydroxymethylphosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082356", "l": "HSF1-mediated gene expression (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56790", "l": "cob(II)alamin-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15365", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61796", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP = AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58591", "l": "dihydroprecondylocarpine acetate + NADPH <=> (+)-vincadifformine + acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74353", "l": "2 (S)-lactate(out) + prostaglandin E3(in) => 2 (S)-lactate(in) + prostaglandin E3(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36047", "l": "A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+)", "d": [], "t": []}, {"i": "EC:1.2.99.8", "l": "\"glyceraldehyde dehydrogenase (FAD-containing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62990", "l": "dodecanoate + NH4(+) => dodecanamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687465", "l": "HSV1 RIR1 binds RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2464822", "l": "RDH12 reduces atRAL to atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71431", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0072570", "l": "ADP-D-ribose binding", "d": ["Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51493", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41600", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18624", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 <=> a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031964", "l": "beta-alanyl-histamine hydrolase activity", "d": ["Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697077", "l": "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209815", "l": "Tyrosine is monoiodinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350598", "l": "Arginine<=>Agmatine+CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66397", "l": "ATP + cholate(in) + glutathione(in) + H2O => ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31344", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10722", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione => 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33492", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811427", "l": "COPI vesicle uncoating at the ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798044", "l": "BTG2 binds CCR4-NOT complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604732", "l": "Autocatalytic activation of proMMP13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55336", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine = a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12618", "l": "ATP + N-acetyl-alpha-D-galactosamine => ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388833", "l": "Phosphorylation of CTLA-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047943", "l": "glutamate-methylamine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664850", "l": "ATM binds PEX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437118", "l": "GPVI stimulates PI3K beta, gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807872", "l": "Active ARF recruits coatomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47830", "l": "a ganglioside GD1b + N-acetylneuraminate => a ganglioside GT1b + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57951", "l": "2-hydroxytoluene + H(+) + NADH + O2 <=> 3-methylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66629", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 => (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043866", "l": "adenylyl-sulfate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45515", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63738", "l": "2-phenylethanol + NADP(+) => 2-phenylacetaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45628", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] = holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:2.3.2.28", "l": "\"L-allo-isoleucyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018804", "l": "RAC3 GEFs activate RAC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912367", "l": "MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984733", "l": "Kinesin-3 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002460", "l": "P4HB binds Collagen chains (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.426", "l": "\"UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32675", "l": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.28", "l": "\"alpha,alpha-trehalase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40825", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42207", "l": "corticosterone + NAD(+) <=> 11-dehydrocorticosterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55115", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018768", "l": "2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943083", "l": "US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696564", "l": "USP25 deubiquitinates DDX58 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68364", "l": "4-CDP-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391158", "l": "SIRP alpha binds CD47 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64895", "l": "holo-[ACP] + tetradecanoyl-AMP <=> AMP + H(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692867", "l": "HRH3 binds pitosilant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50191", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41476", "l": "an acyl-CoA + zymosterol = CoA + zymosterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34651", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14585", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103009", "l": "3-chlorotoluene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 = 3-chlorobenzyl alcohol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093327", "l": "EPHA binds TIAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23233", "l": "4 Fe(III)-[cytochrome c] + hydrazine => 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10751", "l": "H(+) + hydrogencarbonate <=> CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22346", "l": "(R)-rosmarinate + CoA => (2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781905", "l": "ZRANB1 binds APC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653957", "l": "Rag dimer formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31712", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19104", "l": "2-butyne-1,4-diol + NAD(+) <=> 4-hydroxy-2-butynal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76164", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333678", "l": "CPNEs bind PL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627056", "l": "Procaspase 9 forms dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675656", "l": "EDA:EDAR binds EDARADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33282", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45218", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018648", "l": "methanesulfonate monooxygenase activity", "d": ["Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59061", "l": "(20S)-ginsenoside Rg3 + H2O => (20S)-ginsenoside Rh2 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24208", "l": "1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.292", "l": "\"1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873918", "l": "Transphosphorylation of JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809680", "l": "MTMR12 binds MTM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68052", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": [], "t": []}, {"i": "EC:4.6.1.19", "l": "\"ribonuclease T2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050217", "l": "propioin synthase activity", "d": ["Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27301", "l": "2-formylbenzoate + H2O + NAD(+) <=> 2 H(+) + NADH + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34809", "l": "camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10772", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:3.2.1.86", "l": "\"6-phospho-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26136", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015649", "l": "2-keto-3-deoxygluconate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)."], "t": []}, {"i": "RHEA:29943", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203553", "l": "eNOS binds NOSIP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866941", "l": "MID1IP1 binds THRSP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47856", "l": "a ganglioside GD1a (d18:1(4E)) + H2O = a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791016", "l": "SFTPB binds itself (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34065", "l": "2'-deamino-2'-hydroxyparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43259", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43625", "l": "2-aminomalonate semialdehyde + H(+) => aminoacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404200", "l": "IGF1,2 binds IGF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76909", "l": "2-methylcyclohexanone + H(+) + NADPH + NH4(+) => (1S)-2-methyl-cyclohexylamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66760", "l": "ATP + H2O + kainate(in) = ADP + H(+) + kainate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57422", "l": "H(+) + NAD(+) + 2 reduced [cytochrome P450] => NADH + 2 oxidized [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50287", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58465", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169192", "l": "PTP1B dephosphorylates GHR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.-.-", "l": "\"Intramolecular lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62845", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42463", "l": "dibenzofuran + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362417", "l": "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24005", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46449", "l": "2 L-tyrosyl-tRNA(Tyr) => cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44511", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390835", "l": "DRD1,5 bind DA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30924", "l": "(R)-glycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42020", "l": "11-dehydrocorticosterone + NAD(+) = H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60044", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246444", "l": "SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11051", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938913", "l": "RUNX1 binds ELF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.17", "l": "\"calcium/calmodulin-dependent protein kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56998", "l": "apulose => aldehydo-D-apiose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11913", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) => 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15957", "l": "D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.7", "l": "\"altronate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25308", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 7,8-dihydroneopterin + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31454", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> a cardiolipin + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2974737", "l": "NOTCH2 binds MDK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41523", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671737", "l": "p-T774-PKN1 binds CDC25C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37849", "l": "daunorubicin + 2 H2O + NADP(+) => 13-dihydrodaunorubicin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25995", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-epi-isozizaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69577", "l": "2-oxoadipate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] => CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222020", "l": "NUAK1 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25666", "l": "(2E)-geranyl diphosphate = beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097678", "l": "SOCS family protein binding", "d": ["Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45966", "l": "2 AMP + ATP + 2 H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70971", "l": "citrate <=> isocitrate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61920", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O = (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72948", "l": "acetate(out) + 2 Na(+)(out) => acetate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708557", "l": "FBXL17 binds BACH1:MAFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43726", "l": "H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase] => (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102036", "l": "methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity", "d": ["Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] = an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692738", "l": "HRH2 binds HRH2 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9769235", "l": "MAGED1 binds NPAS4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17479", "l": "CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine => precorrin-6B + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411402", "l": "Activation of NLK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55986", "l": "(R)-prunasin + H(+) + UDP => (R)-mandelonitrile + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28534", "l": "dTTP + H2O = diphosphate + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45193", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14571", "l": "H2O + propanal => propane-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13335", "l": "beta-D-fructose 2-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54873", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 => (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102181", "l": "4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 = 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37962", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004045", "l": "aminoacyl-tRNA hydrolase activity", "d": ["Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684052", "l": "PIAS4 SUMOylates MDC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428750", "l": "Gq activation by TP receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29966", "l": "H(+)(in) + inosine(in) <=> H(+)(out) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11016", "l": "allantoate + H2O = (S)-ureidoglycolate + urea", "d": [], "t": []}, {"i": "EC:3.5.3.4", "l": "\"allantoicase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72103", "l": "Formation of pre-mRNPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696564", "l": "USP25 deubiquitinates DDX58 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68778", "l": "diphosphate + germacrene A => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69338", "l": "(Z)-alkanethial oxide => (E)-alk-1-en-1-SO-peroxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.73", "l": "\"inosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16204", "l": "4-amino-4-deoxychorismate <=> 4-aminobenzoate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019161", "l": "diamine transaminase activity", "d": ["Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34906", "l": "4 glutathione + 2 H(+) + selenite <=> glutathione disulfide + 3 H2O + selenodiglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629918", "l": "NEIL1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53540", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25443", "l": "(2E,6E)-farnesyl diphosphate <=> delta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033490", "l": "TYSND1 cleaves PHYH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16475", "l": "5-oxohexanoate + H(+) => cyclohexane-1,3-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102543", "l": "epsilon-rhodomycinone methylesterase activity", "d": ["Catalysis of the reaction: epsilon-rhodomycinone + H2O = 15-demethoxy-epsilon-rhodomycinone + methanol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40903", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16930", "l": "2 benzoyl-CoA + L-ornithine => 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61694", "l": "AMP + L-threonyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047046", "l": "homoisocitrate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622604", "l": "BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61787", "l": "L-allulose <=> keto-L-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109858", "l": "MAP2K2 binds MAPK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864453", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749215", "l": "MCM8 binds CDC6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50241", "l": "[hyaluronan](n) => n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32140", "l": "ATP + CoA + malonate => AMP + diphosphate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9626817", "l": "PKC phosphorylates NCF1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5627775", "l": "Autophosphorylation of PAK1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57093", "l": "AH2 + S-(methylsulfanyl)glutathione => A + glutathione + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794357", "l": "SHANK proteins bind GKAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25351", "l": "H2O + L-cysteinyl-tRNA(Pro) = H(+) + L-cysteine + tRNA(Pro)", "d": [], "t": []}, {"i": "EC:3.6.1.n2", "l": "\"L-cysteinyl-tRNA(Pro)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66522", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380780", "l": "Activation of Src (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868340", "l": "CDK5:p25 phosphorylates lamin B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51709", "l": "D-altritol + NAD(+) => H(+) + keto-D-tagatose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222376", "l": "NOX2 generates superoxide from oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48937", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39638", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44315", "l": "1-tetradecanoylglycerol + H2O <=> glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27832", "l": "beta-phellandrene + diphosphate => neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17461", "l": "D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.37", "l": "\"sedoheptulose-bisphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75225", "l": "H(+) + L-fuconate => H2O + L-fucono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106433", "l": "O6-methyl-dGTP hydrolase activity", "d": ["Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+."], "t": []}, {"i": "RHEA:67600", "l": "H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38918", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0042800", "l": "histone H3K4 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982617", "l": "CYGB:O2 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15171", "l": "L-glutamate + succinate => H2O + N-succinyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol => 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0019207", "l": "kinase regulator activity", "d": ["Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050385", "l": "ureidoglycolate lyase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336454", "l": "MMGT1 transports Mg2+ from cytosol to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43740", "l": "ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36337", "l": "D-glucarate + 2 H(+) + NADH => D-glucuronate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43283", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465940", "l": "atRAL is reduced to atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56542", "l": "1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001154", "l": "TFIIIB-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69178", "l": "2-hydroxy-2-methylpropanoate + L-lysyl-[protein] => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69587", "l": "GMP + inosine <=> guanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33944", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59432", "l": "3-hydroxypropanal + H2O + NAD(+) = 3-hydroxypropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18197", "l": "N-cyclohexylformamide = cyclohexyl isocyanide + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.103", "l": "\"cyclohexyl-isocyanide hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.1", "l": "\"dATP(dGTP)--DNA purinetransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050533", "l": "5-phytase activity", "d": ["Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426158", "l": "SREBP1A,1C binds the GPAM promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821395", "l": "PAXIP1 binds PAGR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22694", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => 3-hydroxybenzoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047468", "l": "phosphoglucomutase (glucose-cofactor) activity", "d": ["Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047150", "l": "betaine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250498", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40952", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O => acetate + L-2,4-diaminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41827", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975594", "l": "PLB1 hydrolyses RPALM to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918229", "l": "Phosphorylation and release of IRF3/IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640862", "l": "Tankyrase binds AXIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21716", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": [], "t": []}, {"i": "EC:1.14.16.6", "l": "\"mandelate 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809254", "l": "MTMR8 binds MTMR9 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0048039", "l": "ubiquinone binding", "d": ["Binding to ubiquinone, a quinone derivative with a tail of isoprene units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71908", "l": "GDP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264622", "l": "Cho is acetylated to AcCho by CHAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13926", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17062", "l": "H(+) + NADPH + O2 + phenol => catechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28930", "l": "3,4,5-trihydroxybenzoate + O2 <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675206", "l": "PEA15 binds MAPK monomers and dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25462", "l": "diphosphate + sibirene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75811", "l": "acetoacetate(out) + Na(+)(out) = acetoacetate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033592", "l": "RNA strand annealing activity", "d": ["An activity that facilitates the formation of a complementary double-stranded RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0036468", "l": "L-dopa decarboxylase activity", "d": ["Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine."], "t": []}, {"i": "RHEA:12272", "l": "H(+) + L-dopa = CO2 + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72402", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) <=> 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.6", "l": "\"pyroglutamyl-peptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25537", "l": "ent-copalyl diphosphate => diphosphate + ent-sandaracopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050630", "l": "(iso)eugenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29047", "l": "a menaquinone + 2 H(+)(in) + H2 = a menaquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660980", "l": "p-S276-RELA binds RELB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41041", "l": "1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10437", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48016", "l": "4-methyl-5-nitrocatechol + NADH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034554", "l": "3,3',5-tribromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0042910", "l": "xenobiotic transmembrane transporter activity", "d": ["Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62277", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine => 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434030", "l": "TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27643", "l": "adenosine + phosphate => adenine + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33451", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] = AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70699", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34077", "l": "a 1-acyl-sn-glycero-3-phosphate + phosphate => an acyl phosphate + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36325", "l": "(9Z)-octadecen-1-ol + CoA + 2 NADP(+) => (9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391941", "l": "BLT receptors can bind LTB4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69873", "l": "(22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009817", "l": "Acitretin binds to RAR:RXR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693061", "l": "STAMBP binds STAM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950344", "l": "Expression of BolA-like protein 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975873", "l": "IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63974", "l": "AH2 + pyriculol => A + dihydropyriculol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75637", "l": "10-hydroperoxy-(8E)-octadecenoate => (9Z)-octadecenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63814", "l": "AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine) => ATP + N(8)-citryl-spermidine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31844", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA => 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67548", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030345", "l": "structural constituent of tooth enamel", "d": ["The action of a molecule that contributes to the structural integrity of tooth enamel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624798", "l": "LBR binds KPNB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45095", "l": "H2O + N-octanoylsphing-4-enine <=> octanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33032", "l": "H(+) + keto-D-fructose + NADH => D-sorbitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77077", "l": "Capping complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67496", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018644", "l": "toluene 2-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + H+ + NADH + O2 = 2-hydroxytoluene + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69165", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) => 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033881", "l": "bile-acid-CoA transferase activity", "d": ["Catalysis of the reaction: deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68459", "l": "(S)-3-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41929", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH => NADP(+) + octadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39061", "l": "26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114558", "l": "Thrombin-activated PARs activate Gq (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50003", "l": "butane + H(+) + NADH + O2 <=> butan-1-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088130", "l": "PLK1 binds FOXM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74507", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17938", "l": "dihydroxyacetone phosphate => methylglyoxal + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35001", "l": "ADP(out) + ATP(in) => ADP(in) + ATP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706293", "l": "Active FLT3 binds to CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694527", "l": "Loss of SAR1B GTPase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74483", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-cyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49613", "l": "(R)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26317", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": [], "t": []}, {"i": "EC:4.1.99.20", "l": "\"3-amino-4-hydroxybenzoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-937192", "l": "Cysteine from cystathionine and vice versa (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3076905", "l": "Extracellular BTD hydrolyses BCTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69804", "l": "ATP + benzoate + H(+) => benzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59524", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] = 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56340", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250264", "l": "TXNIP binds reduced thioredoxin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34101", "l": "CO2 + norspermidine => carboxynorspermidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167419", "l": "The receptor:G-protein complex releases GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481007", "l": "Exocytosis of platelet alpha granule contents (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56470", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752950", "l": "Expression of Olfactory Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664214", "l": "ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832834", "l": "Expression of ZNF521 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985153", "l": "OASL binds DDX58 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56342", "l": "ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33700", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015231", "l": "5-formyltetrahydrofolate transmembrane transporter activity", "d": ["Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395768", "l": "LPL hydrolyses TGs from mature CMs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31303", "l": "a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.36", "l": "\"flavin reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675194", "l": "Activated MAPK phosphorylates RAF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70509", "l": "dimethylallyl phosphate + H(+) + phosphate => dimethylallyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57226", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GTP => glyoxal + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74986", "l": "Elongation of pre-rRNA transcript (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034539", "l": "3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626228", "l": "The distal appendage proteins recruit TTBK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050047", "l": "leucine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-leucine = (3R)-beta-leucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57669", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21721", "l": "formamide => H2O + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51023", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] <=> an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76017", "l": "(3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate trimer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788623", "l": "p-Y-STATs translocate to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44017", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70635", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33118", "l": "malonate(in) <=> malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140032", "l": "glycosylation-dependent protein binding", "d": ["Binding to a protein upon glycosylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12162", "l": "3-dehydro-2-deoxy-D-gluconate + H(+) + NADH => 2-deoxy-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10616", "l": "(2R,3S)-catechin + H2O + NADP(+) = (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.17.1.3", "l": "\"leucoanthocyanidin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60823", "l": "H2O + NADPH <=> adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051721", "l": "protein phosphatase 2A binding", "d": ["Binding to protein phosphatase 2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935930", "l": "miR-18a binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67469", "l": "H2O + malonyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191784", "l": "snRNA Cap hypermethylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675431", "l": "PP2A dephosphorylates RAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-874087", "l": "SGT1 binds HSP90 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033748", "l": "hydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: H2 + A = AH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16648", "l": "H2O + hexadecanoyl-CoA <=> CoA + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28020", "l": "2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine => enterobactin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69615", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47175", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50878", "l": "a hydroxy polyunsaturated fatty acid + H2O + NADP(+) => a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32987", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36519", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31371", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.212", "l": "\"2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59003", "l": "H2O + O2 + propanal <=> H(+) + H2O2 + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.98.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30168", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0035758", "l": "chemokine (C-C motif) ligand 21 binding", "d": ["Binding to chemokine (C-C motif) ligand 21."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37553", "l": "2-oxoglutarate + D-kanosamine 6-phosphate => 3-dehydro-D-glucose 6-phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61846", "l": "H(+) + solasodine 3-beta-D-glucoside + UDP => solasodine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49001", "l": "aurachin C + H(+) + NADH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25501", "l": "(2E)-geranyl diphosphate => diphosphate + terpinolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392195", "l": "Gi activation by P2Y purinoceptor 12 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37252", "l": "cysteamine S-phosphate + H2O => cysteamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71448", "l": "D-alanine(in) + Na(+)(in) => D-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43481", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23868", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone", "d": [], "t": []}, {"i": "EC:4.1.3.35", "l": "\"(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16627", "l": "CoA + thioacetate => acetyl-CoA + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693061", "l": "STAMBP binds STAM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53554", "l": "18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12180", "l": "anthranilate + S-adenosyl-L-methionine = H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.111", "l": "\"anthranilate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954117", "l": "E2F6:TFDP1 binds EPC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70533", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381607", "l": "Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732629", "l": "PPARG binds PPARG agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13676", "l": "[protein-PII]-L-tyrosine + UTP <=> [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381158", "l": "ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46610", "l": "ADP + H(+) + O-phospho-L-threonyl-[protein] => ATP + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44138", "l": "CoA + hexadecanyl dodecanoate => dodecanoyl-CoA + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23617", "l": "1,2-dihydro-alpha-santonin + NADP(+) => alpha-santonin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3274540", "l": "Defective G6PC does not hydrolyze glucose 6-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944255", "l": "Association of procollagen type VII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47037", "l": "uridine in 5S rRNA => pseudouridine in 5S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163676", "l": "Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953013", "l": "E2F7 binds E2F8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190263", "l": "FGFR3b binds to FGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446372", "l": "Association of  PARVA with TESK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591086", "l": "SERPINA5 binds activated protein C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693608", "l": "Initial resection of double-strand break ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74238", "l": "H2O + L-threonyl-tRNA(Ser) <=> L-threonine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32683", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 = 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.47", "l": "\"5-(hydroxymethyl)furfural oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18022", "l": "a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GD1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56574", "l": "a globoside Gb3Cer + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24078", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADH => a 3beta-hydroxy-Delta(5)-steroid + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641134", "l": "SMURF2 binds AXIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59948", "l": "H2O + prostaglandin F2alpha-CoA = CoA + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159796", "l": "Furin cleaves pro-factor IX to factor IX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948034", "l": "FGR binds LDL:LRP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190245", "l": "FGFR1b binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70913", "l": "(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46991", "l": "(R)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62324", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28163", "l": "cytidine + GTP => CMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65524", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009558", "l": "IL34 dimer binds SDC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996755", "l": "ZFPM proteins bind GATA proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54219", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38827", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "56.255037492017777", "identifiers": [{"i": "GO:0016746", "l": "acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027274", "l": "EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30213", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide => 2 Fe(III)-[cytochrome c] + H2O + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68090", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase] => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047280", "l": "nicotinamide phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53580", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60510", "l": "an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine => a guanosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65910", "l": "H2O + L-alanine + xanthurenate => 3-hydroxy-L-kynurenine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867041", "l": "EGFR phosphorylates EPS15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031859", "l": "platelet activating factor receptor binding", "d": ["Binding to a platelet activating factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2534365", "l": "Slo3 Potassium Transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22360", "l": "D-glutamate = 5-oxo-D-proline + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.48", "l": "\"D-glutamate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.7", "l": "\"ADP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.99", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810376", "l": "ING2 binds PI5P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0015252", "l": "proton channel activity", "d": ["Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}, {"i": "REACT:R-HSA-9729542", "l": "OTOP1 transports H+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49966", "l": "H2O2 + phenazine => 5,10-dihydrophenazine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16015", "l": "AMP + diphosphate + glycyl-tRNA(Gly) => ATP + glycine + tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264458", "l": "Proteasome mediated degradation of COP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047787", "l": "delta4-3-oxosteroid 5beta-reductase activity", "d": ["Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41744", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051982", "l": "copper-nicotianamine transmembrane transporter activity", "d": ["Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166214", "l": "FA anion flip-flops to the opposite surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71024", "l": "L-leucine(in) + L-phenylalanine(out) => L-leucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71504", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52560", "l": "2-dehydro-D-erythronate = 3-dehydro-D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035410", "l": "dihydrotestosterone 17-beta-dehydrogenase activity", "d": ["Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65395", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH <=> (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23610", "l": "cyanurate + isopropylamine => H(+) + H2O + N-isopropylammelide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018489", "l": "vanillate monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018470", "l": "4-hydroxybutaraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675790", "l": "MTORC1 dissociates from ULK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-500717", "l": "Activation of GRIK3 homomer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806629", "l": "Formation of tonofilament bundles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64324", "l": "(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64458", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30502", "l": "H(+) + N,N-dihydroxy-L-valine <=> (E)-2-methylpropanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53905", "l": "ATP + L-threonyl-[tau protein] => ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044654", "l": "starch alpha-glucosidase activity", "d": ["Catalysis of the reaction: starch + H2O = alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202307", "l": "Change of PKC theta conformation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369028", "l": "ABCAs mediate lipid efflux (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928614", "l": "EFNB:GRB4 binds GIT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17464", "l": "D-sedoheptulose 1,7-bisphosphate + H2O <=> D-sedoheptulose 7-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805205", "l": "GPR35 binds kynurenic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48504", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60079", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 <=> 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73826", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13741", "l": "3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine", "d": [], "t": []}, {"i": "EC:2.6.1.28", "l": "\"tryptophan--phenylpyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20076", "l": "D-allothreonine <=> acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050530", "l": "glucosylglycerol 3-phosphatase activity", "d": ["Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37799", "l": "2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876472", "l": "NPC2 binds CHOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73691", "l": "3'-AMP(out) + phosphate(in) = 3'-AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41048", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50864", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031842", "l": "type 1 neuropeptide Y receptor binding", "d": ["Binding to a type 1 neuropeptide Y receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912627", "l": "CBL ubiquitinates PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60443", "l": "H2O + methyl acetate <=> acetate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71049", "l": "glycine(out) + L-phenylalanine(in) => glycine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574845", "l": "AJUBA binds centrosome-associated AURKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65732", "l": "2-oxoglutarate + heptyl sulfate + O2 = CO2 + H(+) + heptanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73359", "l": "ATP + beta-alanine + dopamine = AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67039", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 <=> (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042988", "l": "X11-like protein binding", "d": ["Binding to X11-like protein, a neuron-specific adaptor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22407", "l": "beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625482", "l": "PTK2 binds activated EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63641", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) => 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24211", "l": "1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089971", "l": "Secretion of collagens (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008566", "l": "mitochondrial protein-transporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50652", "l": "2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70008", "l": "anthranilate + ATP + H(+) => 2-aminobenzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24080", "l": "ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": [], "t": []}, {"i": "EC:6.1.1.2", "l": "\"tryptophan--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23697", "l": "myo-inositol + O2 => D-glucuronate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25745", "l": "(E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-pentahomomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15699", "l": "2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase] => (2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0051731", "l": "polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050567", "l": "glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46635", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.293", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167683", "l": "TrkA phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53188", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21435", "l": "(S)-malate + NAD(+) <=> H(+) + NADH + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70535", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928639", "l": "p-EFNB binds GRB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29557", "l": "alpha-D-glucose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018508", "l": "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66411", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727188", "l": "ATP4A:ATP4B binds PPIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26034", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29879", "l": "ATP + H2O + L-arginine(out) = ADP + H(+) + L-arginine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20488", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61552", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13920", "l": "(-)-menthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55813", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762343", "l": "PREDL:ALB dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.112", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0032029", "l": "myosin tail binding", "d": ["Binding to the tail region of a myosin heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10789", "l": "2-dehydro-D-gluconate + ATP => 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55154", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein] => H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52983", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12164", "l": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.1", "l": "\"aryl sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72672", "l": "The 60S subunit joins the translation initiation complex  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46182", "l": "2-methylbutanoyl-CoA + AMP + diphosphate => 2-methylbutanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19881", "l": "GTP + L-lysyl-[protein] = diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21705", "l": "H2O + L-tyrosine => NH4(+) + phenol + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202731", "l": "JAM3 dimerises (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60121", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine => H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14488", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-juneol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76899", "l": "cyclohexylamine + H2O + NADP(+) = cyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57742", "l": "a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH => a 2,3-saturated meromycolyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40816", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54606", "l": "2-hydroxydecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + decanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45828", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23679", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698754", "l": "p-STAT5 binds the NOX4 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48800", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591052", "l": "PROCR binds Protein C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46639", "l": "5beta-dihydrotestosterone + NADP(+) <=> H(+) + NADPH + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39316", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73523", "l": "TTP(out) + UTP(in) = TTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0047929", "l": "gluconate dehydratase activity", "d": ["Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48938", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein] => 2-oxoglutarate + L-prolyl-[Skp1 protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23435", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64364", "l": "prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18630", "l": "ATP + NAD(+) => ADP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56223", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35088", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate => D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47750", "l": "a ubiquinol + n Na(+)(out) + NAD(+) => a ubiquinone + H(+) + n Na(+)(in) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36445", "l": "6,8-dimethyl-6,7-didehydroergoline + H2O => dihydrochanoclavine-I aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41307", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12706", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine => [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648268", "l": "HTR1A binds HTR1A antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33395", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester = GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42355", "l": "(R)-nicotine + A + H2O <=> (R)-6-hydroxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047137", "l": "N-hydroxy-2-acetamidofluorene reductase activity", "d": ["Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442913", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012073", "l": "Autocatalytic phosphorylation of FGFR3c P250R mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171122", "l": "LDL + LDLR => LDL:LDLR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803892", "l": "SFN dimer binds BAX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47259", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33535", "l": "H2O + lanosteryl ester = a carboxylate + H(+) + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68382", "l": "2-oxosuccinamate + L-serine => 3-hydroxypyruvate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17092", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate <=> D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11120", "l": "cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)", "d": [], "t": []}, {"i": "EC:4.2.1.104", "l": "\"cyanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72192", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633460", "l": "MDM2 binds TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004633", "l": "phosphopantothenoylcysteine decarboxylase activity", "d": ["Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41220", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.41", "l": "\"sterol 24-C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43373", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866321", "l": "VLDL binds APOC1 and APOC4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20177", "l": "pyridoxine + UDP-alpha-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.160", "l": "\"pyridoxine 5'-O-beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008910", "l": "kanamycin kinase activity", "d": ["Catalysis of the reaction: ATP + kanamycin = ADP + 2 H+ + kanamycin 3'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51254", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30092", "l": "a ubiquinone + D-alanine + H2O => a ubiquinol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51728", "l": "dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50406", "l": "1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein] => (2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57134", "l": "(R)-octopamine + H2O + L-dehydroascorbate => L-ascorbate + O2 + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008684", "l": "TBK1 phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63582", "l": "20-hydroxyecdysone + phosphate => 20-hydroxyecdysone 22-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71917", "l": "2 Na(+)(in) + tauronorcholate(in) => 2 Na(+)(out) + tauronorcholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36623", "l": "3-phenylpyruvate + S-adenosyl-L-methionine = (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.281", "l": "\"phenylpyruvate C(3)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41869", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23751", "l": "ATP + GTP <=> diphosphate + pppGp(2'-5')A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70809", "l": "4-deoxy-4-sulfo-D-erythrulose => 4-deoxy-4-sulfo-D-erythrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008432", "l": "JUN kinase binding", "d": ["Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052913", "l": "16S rRNA (guanine(966)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24073", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12095", "l": "(S)-acetoin <=> (R)-acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55067", "l": "4-methylpentanoyl-CoA + H2O <=> 4-methylpentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59923", "l": "(2E)-octenal + H2O + NAD(+) <=> (2E)-octenoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201457", "l": "BMP2 binds to the receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015133", "l": "uronic acid transmembrane transporter activity", "d": ["Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22005", "l": "ATP + L-seryl-[myosin light chain] => ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416690", "l": "SEMA4A binds to PLXND1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68398", "l": "a carboxylate + H(+) + H2O2 => a percarboxylic acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49273", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] => calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098821", "l": "BMP receptor activity", "d": ["Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60560", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33039", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33321", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11181", "l": "ATP + L-asparagine + tRNA(Asn) => AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21113", "l": "a globoside Gb3Cer (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67116", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0120250", "l": "fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:39023", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209074", "l": "WG, FZ and ARR bind to each other (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46289", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21603", "l": "anthranilate + benzoyl-CoA <=> CoA + N-benzoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42567", "l": "uridine(38/39) in tRNA <=> pseudouridine(38/39) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051991", "l": "UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity", "d": ["Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62219", "l": "isoepoxydon + NADP(+) <=> H(+) + NADPH + phyllostine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64002", "l": "CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9675026", "l": "Formation of the MLL1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53402", "l": "(13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38126", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46652", "l": "epitestosterone + H(+) + NADPH = 5beta-dihydroepitestosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34803", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.211", "l": "\"bisdemethoxycurcumin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56168", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023163", "l": "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63591", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64414", "l": "n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10186", "l": "3-oxoadipate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163688", "l": "Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38148", "l": "carbon disulfide + H2O => carbonyl sulfide + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68804", "l": "H2O + kojibiose = alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56670", "l": "7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29528", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211950", "l": "CYP24A1 24-hydroxylates CTL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013023", "l": "RHOB GEFs activate RHOB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16407", "l": "benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH => benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112514", "l": "JAK activation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187575", "l": "Ubiquitination of phospho-p27/p21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27287", "l": "(S)-acetoin + NAD(+) => diacetyl + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76532", "l": "H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2 => H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66782", "l": "N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592436", "l": "Initial activation of proMMP9 by MMPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1852623", "l": "Ubiquitination of NICD1 by FBWX7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071933", "l": "Arp2/3 complex binding", "d": ["Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51276", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34055", "l": "festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.44", "l": "\"festuclavine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204813", "l": "Interaction of Tie2 and Grb14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43041", "l": "hexadecanoyl-CoA + hexadecasphinganine => CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50295", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "44.334115321568738", "identifiers": [{"i": "GO:0004930", "l": "G protein-coupled receptor activity", "d": ["Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41586", "l": "4-O-dimethylallyl-L-tyrosine + diphosphate => dimethylallyl diphosphate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.3", "l": "\"nitrate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34159", "l": "acetyl-CoA + UDP-N-acetylbacillosamine = CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": [], "t": []}, {"i": "EC:2.3.1.203", "l": "\"UDP-N-acetylbacillosamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791143", "l": "Expression of YIF1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445704", "l": "Calcium Binds Caldesmon (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76649", "l": "(E)-2,3-didehydroadipoyl-CoA + H2O => (3S)-3-hydroxyadipyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730872", "l": "Activation of Calcineurin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40398", "l": "1,2-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205321", "l": "Interaction of KIT and sSCF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218806", "l": "FYN autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50571", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64898", "l": "2 H(+) + 2 phosphate + UMP => 2 H2O + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.53", "l": "\"endopeptidase La\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59751", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60334", "l": "H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14146", "l": "ATP + guanidinoacetate => ADP + H(+) + phosphoguanidinoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44653", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18437", "l": "4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.148", "l": "\"4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67410", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44244", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62264", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) = hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31348", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O => 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39045", "l": "docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18931", "l": "5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O => AH2 + O2 + thiophene-2-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46560", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52455", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211904", "l": "CYP4F12 18-hydroxylates ARA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507868", "l": "Aquaporins passively transport water into cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683467", "l": "CQ, HCQ are protonated to CQ2+, HCQ2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629918", "l": "NEIL1 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55735", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44393", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37247", "l": "H2O + thymidine 3'-monophosphate = phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42414", "l": "ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209924", "l": "Dopa is decarboxylated to dopamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0098988", "l": "G protein-coupled glutamate receptor activity", "d": ["Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49772", "l": "glycine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190263", "l": "FGFR3b binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49756", "l": "H(+) + O2 + protoviolaceinate = CO2 + H2O + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40041", "l": "2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate => 2 ATP + 2 L-glutamate + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72278", "l": "oxalate(in) + sulfate(out) <=> oxalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716947", "l": "ESR1 binds ESR1 agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25637", "l": "H2O + NAD(+) + sulfoacetaldehyde = 2 H(+) + NADH + sulfoacetate", "d": [], "t": []}, {"i": "EC:1.2.1.73", "l": "\"sulfoacetaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2465940", "l": "atRAL is reduced to atROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70660", "l": "H(+)(in) + N,N-dimethylglycine(in) => H(+)(out) + N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34214", "l": "ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806610", "l": "Keratin filament formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76714", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione <=> (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982709", "l": "G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47487", "l": "deoxycholate + NAD(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74292", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate => an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813626", "l": "LEAP2 binds bacteria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0005391", "l": "P-type sodium:potassium-exchanging transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10069", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44593", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16923", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39002", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.204", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42496", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60653", "l": "an N-(acyl)-sphingosylphosphocholine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.154", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14501", "l": "H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": [], "t": []}, {"i": "EC:4.4.1.2", "l": "\"homocysteine desulfhydrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396399", "l": "Fibrillins bind BMPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20861", "l": "(1S,6R)-isopiperitenol + NAD(+) => (6R)-isopiperitenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48211", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10420", "l": "pyruvate + taurine = L-alanine + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75796", "l": "Na(+)(out) + nicotinate(out) => Na(+)(in) + nicotinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53944", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28007", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 => formaldehyde + H2O2 + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32110", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine <=> H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166041", "l": "Transfer of LPS onto TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24083", "l": "ATP + L-tryptophan + tRNA(Trp) <=> AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114254", "l": "CYCS binds to APAF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71320", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) => chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68181", "l": "a short-chain fatty acyl-CoA + H2O => a short-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19562", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 => H2O + NADP(+) + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38833", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54739", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671742", "l": "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60706", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + isoelisabethatriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010943", "l": "NADPH pyrophosphatase activity", "d": ["Catalysis of the reaction: NADPH + H2O = NMNH + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734713", "l": "ORC6 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42605", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72180", "l": "Cleavage of mRNA at the 3'-end (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41051", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806957", "l": "MET receptor dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61805", "l": "ATP + H(+) + L-alanine => diphosphate + L-alanyl-5'-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534365", "l": "Slo3 Potassium Transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14818", "l": "4-maleylacetoacetate => 4-fumarylacetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2169046", "l": "Degradation of TGF-beta receptor complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48931", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111879", "l": "PIP2 hydrolysis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43980", "l": "H(+) + hexadecanoate + NADPH + O2 = 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38150", "l": "carbon disulfide + H2O <=> carbonyl sulfide + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32226", "l": "(6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433488", "l": "Phosphorylation of SHP2 by SFKs (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805426", "l": "CARD8 binds CASP9(1-416) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25295", "l": "acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56877", "l": "(R)-N-acetyl-1-phenylethylamine + H2O => (R)-1-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202241", "l": "Recruitment of SLP-76 to Gads (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757686", "l": "SERPINA6 binds PREDL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29718", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 <=> FMN + glycolaldehyde + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482772", "l": "Release of platelet cytosolic components (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39440", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48960", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14467", "l": "L-histidinol + phosphate => H2O + L-histidinol phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18973", "l": "2-oxoglutarate + deacetoxyvindoline + O2 = 4-O-deacetylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983144", "l": "Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54157", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 => [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29957", "l": "H(+)(out) + thymidine(out) => H(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690785", "l": "BAP1 binds Ub-HCFC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928619", "l": "PAK1 binds RAC1:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46193", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868118", "l": "MAPK12 phosphorylates PTPN3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24773", "l": "7(1)-hydroxychlorophyllide a + NADP(+) => chlorophyllide b + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36948", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682863", "l": "RNF168 binds DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51164", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804425", "l": "TP53 binds POU4F2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66258", "l": "diphosphate + IC-asc-C7-AMP => ATP + H(+) + IC-asc-C7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56087", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O <=> [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696275", "l": "RND2 binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665388", "l": "ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67572", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate = adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.14", "l": "\"cytosol alanyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51882", "l": "(2Z,4E)-2,3,5-trichloromuconate + H(+) => 3,4,6-trichlorocatechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645535", "l": "ALPK1 phosphorylates TIFA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23570", "l": "(3Z)-decenoyl-[ACP] => (2E)-decenoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421831", "l": "trans-Golgi Network Coat Assembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102646", "l": "14betaH-scalarane-17alpha-19-diol synthase activity", "d": ["Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol = all-trans-geranylfarnesol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45585", "l": "3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070182", "l": "DNA polymerase binding", "d": ["Binding to a DNA polymerase."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15673", "l": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.11", "l": "\"acetoacetyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388596", "l": "Melanocortin receptors bind melanocortins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29251", "l": "2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39527", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27996", "l": "D-ribose + xanthine => H2O + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11438", "l": "4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O => 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49957", "l": "5,10-dihydrophenazine 1-carboxylate + O2 => H2O2 + phenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211948", "l": "CYP3A4 can N-demethylate loperamide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50007", "l": "H(+) + NADPH + O2 + tetracycline <=> 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68596", "l": "(2E,6E)-farnesyl diphosphate = beta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167408", "l": "The high affinity receptor complex binds to G-protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70843", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) = L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709098", "l": "DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10173", "l": "(3R)-hydroxybutanoate dimer + H2O => 2 (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0045513", "l": "interleukin-27 binding", "d": ["Binding to interleukin-27."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27467", "l": "ADP-D-glycero-beta-D-manno-heptose + diphosphate => ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24973", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001227", "l": "quercitrin binding", "d": ["Binding to quercitrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70707", "l": "6-sulfo-beta-D-quinovose = 6-sulfo-D-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29421", "l": "H(+)(in) + Na(+)(out) => H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54502", "l": "beta-geranylfarnesene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.731030655927583", "identifiers": [{"i": "GO:0019829", "l": "ATPase-coupled monoatomic cation transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54597", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 => 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75598", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64335", "l": "ATP + CoA + nicotinate <=> AMP + diphosphate + nicotinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11557", "l": "(S)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036949", "l": "NTRK3 binds GRB2:SOS1 through SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003844", "l": "1,4-alpha-glucan branching enzyme activity", "d": ["Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18398", "l": "ATP + L-glutamate + tRNA(Glx) => AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67613", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38739", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32657", "l": "a coniferyl ester + NADPH => a carboxylate + eugenol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69746", "l": "(S)-2-benzylsuccinate + succinyl-CoA <=> (S)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36518", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA <=> 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56871", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202443", "l": "Oligomerization of CARMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50769", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50910", "l": "A + a 3-demethylubiquinol + H2O => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0019777", "l": "Atg12 transferase activity", "d": ["Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages."], "t": []}, {"i": "REACT:R-HSA-5681999", "l": "ATG10 transfers ATG12 from ATG7 to ATG10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34912", "l": "D-methionine(in) => D-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247840", "l": "WLS binds WNT ligands in the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30333", "l": "all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18836", "l": "4-formylbenzenesulfonate + H2O + NAD(+) <=> 4-sulfobenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61860", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 = epoxybetaenone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189488", "l": "UROS transforms HMB to URO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990882", "l": "CDK1 phosphorylates NUP98 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102969", "l": "10-oxogeraniol oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-oxogeraniol + NADP = (6E)-8-oxogeranial + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52402", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH => 4-O-phospho-D-threonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.242", "l": "\"Kdo2-lipid IVA palmitoleoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68486", "l": "CO2 + H2O + undecanal => (2R)-2-hydroperoxydodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24291", "l": "5-formimidoyltetrahydrofolate + glycine <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67865", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32897", "l": "2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050312", "l": "sulfoacetaldehyde lyase activity", "d": ["Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31632", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate => phosphate + pseudaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847537", "l": "RAB43:GTP binds USP8NL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047488", "l": "heparin lyase activity", "d": ["Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28340", "l": "crotonobetainyl-CoA + H2O => (R)-carnitinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18962", "l": "D-allose + L-lysyl-[protein] => H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17742", "l": "NAD(+) + shikimate => 3-dehydroshikimate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018572", "l": "EGFR phosphorylates NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981093", "l": "IL12 bound to IL12R internalises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19148", "l": "D-glucose 6-sulfate + H2O <=> D-glucose + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10081", "l": "dihydrophloroglucinol + NADP(+) => 1,3,5-trihydroxybenzene + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.127", "l": "\"3-(3-hydroxy-phenyl)propanoic acid hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.25", "l": "\"1,4-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672957", "l": "PP2A dephosphorylates KSR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35979", "l": "dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A", "d": [], "t": []}, {"i": "EC:2.5.1.107", "l": "\"verruculogen prenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19193", "l": "A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol", "d": [], "t": []}, {"i": "EC:1.3.99.23", "l": "\"all-trans-retinol 13,14-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362437", "l": "C-terminal Hh fragments are bound by lectins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32685", "l": "2,5-dicarboxyfuran + 2 H(+) + 3 H2O2 => 5-hydroxymethylfurfural + 2 H2O + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24192", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13988", "l": "ATP + L-homoserine <=> ADP + H(+) + O-phospho-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983150", "l": "Proteasomal cleavage of substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664867", "l": "NBR1 binds MAP1LC3B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67558", "l": "adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53837", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54285", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837087", "l": "FASTK binds MT-ND6 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60568", "l": "N-acetyl-L-tryptophan = N-acetyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11441", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 => 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76087", "l": "a dicarboxylate(in) + kynurenate(out) = a dicarboxylate(out) + kynurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51464", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0000828", "l": "inositol hexakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55030", "l": "an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63129", "l": "H2O + N-docosanoyl-ethanolamine => docosanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53831", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 <=> a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62174", "l": "an N-acylethanolamine + phosphate => an N-acylethanolamine phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15607", "l": "H(+) + NH4(+) + pyruvate + sulfate => H2O + L-serine O-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0003887", "l": "DNA-directed DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63961", "l": "abscisate(out) + ATP + H2O => abscisate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709883", "l": "BIL:ALB scavenges O2.- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034882", "l": "cis-aconitamide amidase activity", "d": ["Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086083", "l": "SUMOylation of ING2 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36005", "l": "propanal + pyruvate => (S)-4-hydroxy-2-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36189", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034861", "l": "benzothiazole-2-sulfonate hydrolase activity", "d": ["Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67224", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043895", "l": "cyclomaltodextrin glucanotransferase activity", "d": ["Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029453", "l": "Phosphorylation of VAV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62153", "l": "dGMP + dTTP => dGDP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39911", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.107", "l": "\"beta-methylphenylalanine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51536", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167284", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852331", "l": "GTSE1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76334", "l": "L-aspartate(in) + L-tyrosine(out) <=> L-aspartate(out) + L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55357", "l": "11-cis-retinol => 13-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48342", "l": "a medium-chain fatty acyl-CoA + AMP + diphosphate => a medium chain fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606602", "l": "ASAH1 hydrolyzes ceramide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66454", "l": "1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18070", "l": "L-arginine => D-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32982", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428883", "l": "Recruitment of CAP to ABL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192627", "l": "Viral mRNA Export (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47662", "l": "CoA + H(+) + N-acetyl-L-methionine sulfoximine => acetyl-CoA + L-methionine sulfoximine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12424", "l": "(3S)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.3.1.16", "l": "\"threo-3-hydroxy-L-aspartate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030942", "l": "endoplasmic reticulum signal peptide binding", "d": ["Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26422", "l": "3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": [], "t": []}, {"i": "EC:2.8.2.n2", "l": "\"thyroxine sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36687", "l": "hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25692", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72647", "l": "Cap-bound mRNA is activated by helicases  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20486", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55396", "l": "(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27583", "l": "(S)-2-hydroxymethylglutarate => 2-methyleneglutarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64467", "l": "L-tyrosyl-[protein] + 2 O2 <=> H(+) + H2O2 + L-topaquinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50021", "l": "decanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956568", "l": "RUNX1 binds the core TAL1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15105", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.155", "l": "\"kaempferol 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53785", "l": "beta-muricholate + deoxycholoyl-CoA => beta-muricholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12006", "l": "H(+) + indican + UDP => indoxyl + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66437", "l": "NADP(+) + pentan-3-one => H(+) + NADPH + pent-1-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74177", "l": "a ketone + H(+) + NADH + NH4(+) => a secondary alkyl amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56825", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 => A + cyclooctatin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25169", "l": "6-hydroxyhexan-6-olide => 6-oxohexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47796", "l": "an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}, {"i": "EC:1.4.9.2", "l": "\"aralkylamine dehydrogenase (azurin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.222", "l": "\"4-hydroxytryptamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180003", "l": "S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)."], "t": []}, {"i": "RHEA:75479", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13823", "l": "(S)-2-hydroxyglutarate + CO2 + succinate => 2-oxoglutarate + glutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75210", "l": "Ag(+)(out) <=> Ag(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31335", "l": "CTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": [], "t": []}, {"i": "EC:2.7.7.76", "l": "\"molybdenum cofactor cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74317", "l": "O-isobutanoyl-(R)-carnitine(out) => O-isobutanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "48.267064883444782", "identifiers": [{"i": "GO:0016787", "l": "hydrolase activity", "d": ["Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25813", "l": "H2O + N(1)-acetylspermidine + O2 => 3-acetamidopropanal + H2O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15778", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O => 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74312", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39257", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+) => (13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58795", "l": "ATP + Fe(III)-petrobactin(out) + H2O <=> ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0016716", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32359", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.151", "l": "\"inositol-polyphosphate multikinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724685", "l": "IgE binds omalizumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0005221", "l": "intracellular cyclic nucleotide-activated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts."], "t": []}, {"i": "REACT:R-HSA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65855", "l": "a 3-oxo-Delta(1)-steroid + H2O <=> a 1-hydroxy-3-oxo steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41915", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH <=> hexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19827", "l": "(+)-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034042", "l": "5-formyluracil DNA N-glycosylase activity", "d": ["Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39807", "l": "octadecanoate(in) = octadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74493", "l": "yaequinolone D => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75116", "l": "all-trans-13,14-dihydroretinol + NAD(+) => all-trans-13,14-dihydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102512", "l": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62099", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52237", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38449", "l": "4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose => 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34339", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211247", "l": "Cleavage of DNA by DFF40 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71786", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) <=> 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10376", "l": "ATP + Cu(2+)(in) + H2O = ADP + Cu(2+)(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.9", "l": "\"P-type Cu(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213406", "l": "Disassociation of PLC-gamma1 from LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836763", "l": "RSV dsRNA binds TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768939", "l": "NPAS4 binds NPAS4 gene enhancer elements (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68595", "l": "ORC2 binds ORC3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706293", "l": "Active FLT3 binds to CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67630", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate => ATP + dGMP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57712", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21408", "l": "H2O + L-phenylalanine + NAD(+) = 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.20", "l": "\"phenylalanine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47389", "l": "a tetradecanoate ester + H2O => an aliphatic alcohol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39145", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30413", "l": "benzyl benzoate + CoA => benzoyl-CoA + benzyl alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39898", "l": "7-deoxyloganetate + UDP-alpha-D-glucose <=> 7-deoxyloganate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944250", "l": "Association of procollagen type XXV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218814", "l": "PAK2 autophorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433488", "l": "Phosphorylation of SHP2 by SFKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36825", "l": "CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate => 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41701", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34804", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51252", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76352", "l": "oxaloacetate(in) + sulfate(out) => oxaloacetate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23048", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60055", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65479", "l": "1-propanol + butanoyl-CoA <=> CoA + propyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034639", "l": "L-amino acid efflux transmembrane transporter activity", "d": ["Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54766", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090585", "l": "protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50586", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76787", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,10-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56054", "l": "2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48281", "l": "a ganglioside GM2 + UDP-alpha-D-galactose => a ganglioside GM1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39524", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60078", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+) => 4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050268", "l": "coniferyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15663", "l": "an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA => (E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40261", "l": "(3S)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42444", "l": "L-aspartate + NADP(+) = H(+) + iminosuccinate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034929", "l": "1-hydroxypyrene 7,8-monooxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.-.-", "l": "\"Glycosyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602484", "l": "Activation of proMMP11 by FURIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62628", "l": "a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.11.1.26", "l": "\"NADH-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805126", "l": "AURKB phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627078", "l": "XIAP binds CASP9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211874", "l": "CYP2S1 4-hydroxylates atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2464822", "l": "RDH12 reduces atRAL to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49354", "l": "2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757445", "l": "ST translocates from ER lumen to cytosol of GI cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17153", "l": "CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.45", "l": "\"CDP-glucose 4,6-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903089", "l": "5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity", "d": ["Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204600", "l": "Basigin homodimerises (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19544", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8979071", "l": "KDM6B binds iron (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609737", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN2D (GRIN2D) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18016", "l": "H2O + N(5)-ethyl-L-glutamine <=> ethylamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46203", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3247836", "l": "Retromer recycles WLS to the Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41960", "l": "a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48675", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56027", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18260", "l": "coproporphyrinogen III + 2 H(+) + O2 <=> 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69606", "l": "UTP <=> 3',5'-cyclic UMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34566", "l": "CDP-alpha-D-abequose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17443", "l": "2-oxo-3-sulfanylpropanoate + L-glutamate => 2-oxoglutarate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936563", "l": "ISGylation of DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28131", "l": "baicalin + H2O => baicalein + D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769401", "l": "DKK and KRM bind LRP5/6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250264", "l": "TXNIP binds reduced thioredoxin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873923", "l": "STARD10 binds LPCAT1 and PC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1364044", "l": "PRLR:JAK2 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12311", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) <=> 2 H(+) + L-2-aminoadipate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75868", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709883", "l": "BIL:ALB scavenges O2.- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.1", "l": "\"succinate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004482", "l": "mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849094", "l": "ARHGAP35 binds RASA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53359", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20b) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38821", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24694", "l": "(E)-isoeugenol + acetate + NADP(+) = (E)-coniferyl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48645", "l": "prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0003990", "l": "acetylcholinesterase activity", "d": ["Catalysis of the reaction: acetylcholine + H2O = choline + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.387", "l": "\"isomaltosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76866", "l": "benzylamine + H2O + NAD(+) <=> benzaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709098", "l": "DHFR dimer reduces FOLA to DHF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427570", "l": "Group 3 - Selective Cl- transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72621", "l": "Ribosomal scanning  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33522", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine <=> (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74671", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) = UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56625", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17108", "l": "malonyl-[ACP] + S-adenosyl-L-methionine <=> malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645598", "l": "RRAGC,D hydrolyzes GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23932", "l": "an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41099", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19117", "l": "dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}, {"i": "EC:1.14.17.1", "l": "\"dopamine beta-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51749", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A => 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75317", "l": "chloride(in) + D-serine(in) + 2 Na(+)(in) => chloride(out) + D-serine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35306", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) <=> 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58535", "l": "15alpha-stemmadenine intermediate I + H2O <=> akuammicine + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683831", "l": "CCDC59 binds TTF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16469", "l": "(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70544", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33426", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) <=> diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102088", "l": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP = H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67312", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54461", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18414", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.396", "l": "\"bacteriochlorophyllide-a dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47147", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40611", "l": "H2O + trihexanoylglycerol = 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19428", "l": "H(+) + imidazole-4-acetate + NADH + O2 <=> 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50955", "l": "7-chloro-L-tryptophan + AH2 + O2 <=> A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33693", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203613", "l": "depalmitoylation of eNOS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52886", "l": "2 H(+) + 2 NADPH + nitrobenzene => H2O + N-phenylhydroxylamine + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64553", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46712", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11558", "l": "3-dehydrocarnitine + H(+) + NADH => (S)-carnitine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17372", "l": "glycyrrhizin + H2O <=> 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33107", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-muurolene", "d": [], "t": []}, {"i": "EC:4.2.3.126", "l": "\"gamma-muurolene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051738", "l": "xanthophyll binding", "d": ["Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63535", "l": "angiotensin I + H2O <=> angiotensin-(1-9) + L-leucine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69685", "l": "beta-D-glucose + daidzein + H(+) => daidzein 7-O-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33060", "l": "(R)-dihydrolipoamide + NAD(+) => (R)-lipoamide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29443", "l": "H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141048", "l": "membrane tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to a lipid, where it acts as a marker for a membrane, recognized by the cellular apparatus to target the tagged protein for some cellular process such as autophagy."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801109", "l": "CHM binds RGGT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20325", "l": "N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl", "d": [], "t": []}, {"i": "EC:2.3.1.56", "l": "\"aromatic-hydroxylamine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607058", "l": "Activated protein C:PROCR binds F2R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703436", "l": "STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798624", "l": "ZNF420 binds TP53AIP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917730", "l": "Cargo Recognition And Sorting (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700168", "l": "Active ALK phosphorylates IRS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35200", "l": "(S,S)-tartrate(out) => (S,S)-tartrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11826", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814555", "l": "Integrator complex processes the 3' end of snRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68053", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035484", "l": "CysS248-MPST:TXN2 dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334827", "l": "SUMO-CRABP2 binds atRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15980", "l": "(S)-4-hydroxymandelonitrile <=> 4-hydroxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990137", "l": "plant seed peroxidase activity", "d": ["Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33297", "l": "(E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.119", "l": "\"glucose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66968", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.380", "l": "\"GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854052", "l": "Formation of the SCF-FBXL7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072354", "l": "histone H3T3 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 3) + ATP = histone H3-phosphothreonine (position 3) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 3 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76188", "l": "an L-amino acid tripeptide(out) + 2 H(+)(out) => an L-amino acid tripeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381668", "l": "cAMP activates EPAC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47423", "l": "A + glutaryl-CoA <=> (2E)-glutaconyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32495", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.83", "l": "\"geraniol 8-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25259", "l": "N-acetyl-D-mannosamine 6-phosphate => N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008474", "l": "palmitoyl-(protein) hydrolase activity", "d": ["Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11311", "l": "acetyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + malonyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13525", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.1", "l": "\"camphor 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051061", "l": "ADP reductase activity", "d": ["Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062066", "l": "PSII associated light-harvesting complex II binding", "d": ["Binding to a PSII associated light-harvesting complex II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51478", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O => a ribonucleoside 5'-triphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784735", "l": "PCSK9:LDLR bind to Clathrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12982", "l": "H2O + O2 + S-sulfanylglutathione => glutathione + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102009", "l": "proline dipeptidase activity", "d": ["Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal = L-proline + a standard alpha amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77696", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76548", "l": "acetyl-CoA + D-glutamine => CoA + H(+) + N-acetyl-D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043806", "l": "keto acid formate lyase activity", "d": ["Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76542", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine <=> an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31286", "l": "FAD + H(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58830", "l": "9R,10R-dihydroxyoctadecanoate => (9S,10R)-epoxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41661", "l": "dihydrosanguinarine + NAD(+) => NADH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687520", "l": "MetAsp transforms to L-Asp,isoAsp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61822", "l": "epiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052613", "l": "canthaxanthin 3-hydroxylase activity", "d": ["Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71946", "l": "(S)-malate(out) + 3 Na(+)(out) <=> (S)-malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75824", "l": "Ubiquitination of Cyclin D1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10152", "l": "ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:2.7.2.2", "l": "\"carbamate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41008", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin => 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350901", "l": "Iodide is organified (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034803", "l": "3-hydroxy-2-naphthoate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35379", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74885", "l": "GUCYs converts GTP to cGMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43032", "l": "3-chloro-D-alanine = 2-aminoprop-2-enoate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45383", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429767", "l": "Passive I- efflux mediated by SMCT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839638", "l": "CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69764", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) => a medium chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30265", "l": "2 H2O + 2 monodehydro-L-ascorbate radical => H2O2 + 2 L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419841", "l": "Light stimulates opsin receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49775", "l": "glycine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016161", "l": "beta-amylase activity", "d": ["Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69900", "l": "2 Na(+)(out) + thymidine(out) => 2 Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670414", "l": "KIT mutants bind SFKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296043", "l": "Activation of HCN channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44082", "l": "AMP + diphosphate + undecanoyl-CoA => ATP + CoA + undecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112385", "l": "Addition of nucleotides leads to transcript elongation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17365", "l": "ATP + H2O + Mn(2+)(out) = ADP + H(+) + Mn(2+)(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.5", "l": "\"ABC-type Mn(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32081", "l": "(13E)-labda-7,13-dien-15-ol + diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21981", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52914", "l": "3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O => 3-dimethylallyl-4-hydroxymandelate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37547", "l": "D-glucose 6-phosphate + NAD(+) = 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.361", "l": "\"glucose-6-phosphate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15518", "l": "H2O + N(2),6-disulfo-D-glucosamine => H(+) + N-sulfo-D-glucosamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74456", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19965", "l": "S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)", "d": [], "t": []}, {"i": "EC:4.4.1.3", "l": "\"dimethylpropiothetin dethiomethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507870", "l": "Aquaporins passively transport water out of cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679266", "l": "Beclin-1 complex translocates to the ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75701", "l": "glutathione disulfide + H(+) + NADH => 2 glutathione + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57270", "l": "GMP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681314", "l": "Replication transcription complex binds SARS-CoV-1 genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0061631", "l": "ubiquitin conjugating enzyme activity", "d": ["Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."], "t": []}, {"i": "EC:2.3.2.23", "l": "\"E2 ubiquitin-conjugating enzyme\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64737", "l": "4-hydroxynonanal + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33307", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.195", "l": "\"protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871265", "l": "YAP1 binds TEAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76637", "l": "n H(+)(in) + Mn(2+)(out) => n H(+)(out) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67873", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625674", "l": "Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31525", "l": "3 CO2 + ethene + H2O => 2-oxoglutarate + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16910", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O => 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865994", "l": "GAB1 binds PTPN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32199", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.30", "l": "\"3-ketosteroid 9alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48337", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008043", "l": "MAPK8 phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73664", "l": "(E,E)-piperoyl-CoA + pyrrolidine => CoA + H(+) + piperyline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.184", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408556", "l": "SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31247", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol = prop-2-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19202", "l": "2'-deoxyguanosine + ATP => ADP + dGMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034828", "l": "4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247843", "l": "secretion of WNT ligands (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043273", "l": "CTPase activity", "d": ["Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction."], "t": []}, {"i": "RHEA:29387", "l": "CTP + H2O = CDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55464", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000253", "l": "3-keto sterol reductase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69370", "l": "17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35332", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938158", "l": "PRKCQ gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10464", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = n acetate + chitosan", "d": [], "t": []}, {"i": "EC:3.5.1.41", "l": "\"chitin deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30710", "l": "putrescine + pyruvate <=> 4-aminobutanal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57825", "l": "dAMP + H2O => 2-deoxy-D-ribose 5-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56904", "l": "an acyl-AMP + CoA = AMP + an acyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35997", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46378", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102322", "l": "2-propylphenol monooxygenase activity", "d": ["Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56811", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46683", "l": "2 Fe(III)-[cytochrome b5] + NADH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392749", "l": "Transport of L1 into endosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20640", "l": "D-fructose + D-glucose <=> D-glucono-1,5-lactone + D-sorbitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682388", "l": "Autophagosome maturation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948027", "l": "RNASEs bind bacterial phospholipids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25331", "l": "(R)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75617", "l": "ectocarpin B + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016797", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters."], "t": []}, {"i": "EC:3.1.16.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61363", "l": "ATP + H2O + pheophorbide a(in) <=> ADP + H(+) + pheophorbide a(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656781", "l": "Deltarasin binds PDE6D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64942", "l": "dGMP + H(+) + phosphate => dGDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043799", "l": "glycine oxidase activity", "d": ["Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0016421", "l": "CoA carboxylase activity", "d": ["Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26392", "l": "all-trans-beta-carotene + O2 <=> all-trans-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39283", "l": "a long-chain fatty acid(out) = a long-chain fatty acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.99", "l": "\"fatty acid amide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426489", "l": "RISC binds inexactly matching target RNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13328", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787403", "l": "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69318", "l": "allyl thiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57926", "l": "diphosphate + premutilin => H2O + mutildienyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032800", "l": "Expression of NPPA (ANF) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50742", "l": "glycine + leukotriene F4 => H2O + leukotriene C4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60637", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine => choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.57", "l": "\"caspase-4\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36344", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 => 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49571", "l": "2-glutathionyl-2-methylbut-3-en-1-ol <=> (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33254", "l": "2 sucrose <=> 6-kestotriose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018863", "l": "phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416698", "l": "SEMA5A binds to PLXNB3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209536", "l": "IkB is ubiquitinated and degraded (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964619", "l": "PAK1 binds ARHGEF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21537", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14880", "l": "ATP + L-glutamate <=> ADP + L-glutamyl 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53236", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51379", "l": "dopamine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016995", "l": "cholesterol oxidase activity", "d": ["Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19023", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610867", "l": "HCMV Binds Host Cell Receptor - Endocytic Pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376122", "l": "DSCAM/DSCAML1 homodimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912627", "l": "CBL ubiquitinates PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140791", "l": "histone H2AXS140 phosphatase activity", "d": ["Catalysis of the reaction: histone H2AX serine phosphate (position 140) + H2O = histone H2AX serine (position 140) + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322434", "l": "XIAP dissociates from ub-TLE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607753", "l": "CARD9 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62852", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848339", "l": "PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031874", "l": "type 3 proteinase activated receptor binding", "d": ["Binding to a type 3 proteinase activated receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0032028", "l": "myosin head/neck binding", "d": ["Binding to the head/neck region of a myosin heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604264", "l": "ADAM10 cleaves NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379464", "l": "COMT transfers Met to DOPAC to form HVA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23544", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.240", "l": "\"flavonol-3-O-glycoside glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018701", "l": "2,5-dichlorohydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140260", "l": "mitochondrial proton-transporting ATP synthase complex binding", "d": ["Binding to a mitochondrial proton-transporting ATP synthase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34034", "l": "2'-N-acetylparomamine + H2O <=> acetate + paromamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74786", "l": "tyramine(in) <=> tyramine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21306", "l": "ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10727", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15594", "l": "amicoumacin A 2-phosphate + H2O => amicoumacin A + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30440", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40741", "l": "(20S)-ginsenoside C-Y + 2 D-glucose => (20S)-ginsenoside Rb2 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0051015", "l": "actin filament binding", "d": ["Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69798", "l": "D-aspartyl-tRNA(Asp) + H2O <=> D-aspartate + H(+) + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29989", "l": "adenosine(out) + H(+)(out) => adenosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42669", "l": "L-rhamnofuranose + NADP(+) => H(+) + L-rhamnono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83650", "l": "FasL:Fas binds FADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19253", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine", "d": [], "t": []}, {"i": "EC:3.1.4.12", "l": "\"sphingomyelin phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709360", "l": "H2O2 reduces MetHb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67015", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68469", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032035", "l": "myosin II tail binding", "d": ["Binding to the tail region of a myosin II heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730856", "l": "Autophosphorylation of PAK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.76", "l": "\"deoxyadenosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983147", "l": "Release of E3 from polyubiquitinated substrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034851", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53805", "l": "allodeoxycholoyl-CoA + ursodeoxycholate => allodeoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625699", "l": "FOXO1 and NR3C1 bind TRIM63 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.351", "l": "\"phosphogluconate dehydrogenase [NAD(P)(+)-dependent, decarboxylating]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602473", "l": "Autocatalytic activation of MMP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474266", "l": "Formation of collagen fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17837", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.63", "l": "\"2-carboxy-D-arabinitol-1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76104", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine => (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015324", "l": "peptide-acetyl-CoA secondary active transmembrane transporter activity", "d": ["Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429732", "l": "Multiphospho-CERT1-2 binds PPM1L, VAPA/B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090565", "l": "protein-phosphocysteine-mannitol phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672978", "l": "RAF phosphorylates MAP2K dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32869", "l": "myo-inositol(in) => myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102381", "l": "stevioside glucosyltransferase activity (rebaudioside A forming)", "d": ["Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168393", "l": "STAT5 association with GHR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29474", "l": "D-ribose 5-phosphate + H2O <=> D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16579", "l": "P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate => ADP + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53891", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36596", "l": "hydrogen sulfide + NADP(+) => NADPH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759158", "l": "SQSTM1 oligomerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786789", "l": "FLT3LG dimer binds FLT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627104", "l": "XIAP binds CASP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25670", "l": "sucrose + UDP-alpha-D-galactose = H(+) + loliose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.n2", "l": "\"loliose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42337", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4837364", "l": "Secretion of SOD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001861", "l": "complement component C4b receptor activity", "d": ["Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56258", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63618", "l": "H(+) + prunetin-C(8)-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25192", "l": "chloroacetate + H2O <=> chloride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641205", "l": "RSPO:LGR binds ZNRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73757", "l": "Binding of RRN3 to RNA Polymerase I (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050584", "l": "linoleate 11-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848713", "l": "PTK6 binds BCAR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57024", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:2.2.1.13", "l": "\"apulose-4-phosphate transketolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60387", "l": "enterobactin + H2O <=> N-(2,3-dihydroxybenzoyl)-L-serine trimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38703", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37228", "l": "(E,E)-sorbate + H(+) => (E)-1,3-pentadiene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11776", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.2", "l": "\"stearoyl-[acyl-carrier-protein] 9-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57981", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside F1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102929", "l": "lachrymatory factor synthase activity", "d": ["Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159253", "l": "MMAB adenosylates cob(I)alamin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63387", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45452", "l": "H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450325", "l": "c-FOS activation by phospho ERK1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49899", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate <=> 5,10-dihydrophenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928654", "l": "Clathrin internalises EPH:EFN complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102164", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity", "d": ["Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ = 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0051378", "l": "serotonin binding", "d": ["Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77094", "l": "Formation of cap binding complex (CBC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45560", "l": "L-isoleucine = D-allo-isoleucine", "d": [], "t": []}, {"i": "EC:5.1.1.21", "l": "\"isoleucine 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50680", "l": "H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.122", "l": "\"protein N-terminal glutamine amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11219", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP <=> a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839095", "l": "p-BCR-pFGFR1 binds GRB2:GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422454", "l": "Polysialylation of NCAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18165", "l": "biphenyl + H(+) + NADH + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.18", "l": "\"biphenyl 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37757", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11770", "l": "5-phospho-alpha-D-ribose 1-diphosphate + anthranilate => diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36028", "l": "CoA + NAD(+) + propanal => H(+) + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626067", "l": "EEF1A1:GTP translocates from lysosomal membrane to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63100", "l": "H(+) + ilicicolin C + NADPH + O2 = ascochlorin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2219524", "l": "PDPK1 binds PIP2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0070569", "l": "uridylyltransferase activity", "d": ["Catalysis of the transfer of an uridylyl group to an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106344", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP", "d": ["Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H+ + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]."], "t": []}, {"i": "RHEA:65756", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.46", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53955", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate <=> 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008929", "l": "methylglyoxal synthase activity", "d": ["Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18192", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39908", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose => dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473596", "l": "Collagen type I degradation by MMP15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76025", "l": "18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672174", "l": "Ligand-independent dimerization of PDGFRA extracellular domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72344", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203567", "l": "palmitoylation of eNOS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29510", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-gurjunene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48624", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51620", "l": "CTP + formate + H(+) = CO2 + dCTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19310", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O => (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50661", "l": "3-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692749", "l": "CDC14A,B bind MAPK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54364", "l": "2 acetaldehyde = acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21405", "l": "chloride + O2 => chlorite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018570", "l": "p-cumate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804194", "l": "PRDM1 binds the TP53 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610720", "l": "PKA phosphorylates GLI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74499", "l": "H(+) + NADPH + yaequinolone D = H2O + NADP(+) + penigequinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193700", "l": "p75NTR ICD signals to NF-kB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69825", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75112", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23451", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP <=> CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67526", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine => 4,8-dimethylnonanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73806", "l": "AIR + CO2 => CAIR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.122", "l": "\"L-cysteate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66510", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166363", "l": "TRAF6 binds to hp- IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196857", "l": "PANK2 phosphorylates PanK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17594", "l": "3-phenylpyruvate + L-glutamine => 2-oxoglutaramate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72177", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25015", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tryptophan", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26325", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.n7", "l": "\"5-pentadecatrienyl resorcinol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430190", "l": "p-SLP-76 binds NCK (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450088", "l": "GLUT1 tetramer binds 4xATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44686", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38803", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15252", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-galloyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201608", "l": "Caspase-mediated cleavage of alpha adducin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865276", "l": "PDGF-AB clevage by Furin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9823816", "l": "OPTN binds CASP8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204600", "l": "Basigin homodimerises (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43224", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68185", "l": "a medium-chain fatty acyl-CoA + H2O => a medium chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.76", "l": "\"poly(3-hydroxyoctanoate) depolymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448702", "l": "Caspase-1 active tetramer formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802937", "l": "Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663252", "l": "NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034537", "l": "2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59159", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74364", "l": "coproporphyrin III(out) => coproporphyrin III(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112392", "l": "Resumption of elongation after recovery from pausing (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62203", "l": "ethanol + 2 Fe(III)-[cytochrome c] <=> acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41464", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.70", "l": "\"ent-sandaracopimaradiene 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008868", "l": "galactitol-1-phosphate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44842", "l": "CoA + O-octadecanoyl-(R)-carnitine => (R)-carnitine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879222", "l": "MDP:NLRP1 binds ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60753", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone => CoA + jasmolin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77613", "l": "3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol) => 2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005171", "l": "hepatocyte growth factor receptor binding", "d": ["Binding to an hepatocyte growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036424", "l": "L-phosphoserine phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419426", "l": "Cannabinoid receptors can bind cannabinoids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427570", "l": "Group 3 - Selective Cl- transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854290", "l": "TBC1D20 binds NS5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15865", "l": "AH2 + O2 + tryptamine = 4-hydroxytryptamine + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.59", "l": "\"tryptamine 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858475", "l": "TNFSF9 binds TNFRSF9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975857", "l": "TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70887", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) = L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229132", "l": "AP4 binds APP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19888", "l": "(S)-reticuline + O2 <=> (S)-scoulerine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54052", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + tau-cadinol", "d": [], "t": []}, {"i": "EC:4.2.3.173", "l": "\"tau-cadinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15177", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}, {"i": "EC:3.1.1.5", "l": "\"lysophospholipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11765", "l": "H2O + methylguanidine => methylamine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44602", "l": "a fatty acyl-AMP + diphosphate => a fatty acid + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692738", "l": "HRH2 binds HRH2 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37913", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67993", "l": "AH2 + trichloroethene => (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46157", "l": "15,9'-di-cis-phytofluene + a plastoquinone => 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50830", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25367", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) = H(+) + momilactone A + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54728", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.1.3.15", "l": "\"acetyl-CoA carboxytransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.104", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24496", "l": "4-O-deacetylvindoline + acetyl-CoA = CoA + vindoline", "d": [], "t": []}, {"i": "EC:2.3.1.107", "l": "\"deacetylvindoline O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015311", "l": "monoamine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177284", "l": "PKA phosphorylates PDE4B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051750", "l": "delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity", "d": ["Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57597", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71766", "l": "2-oxoglutarate(out) + citrate(in) <=> 2-oxoglutarate(in) + citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32751", "l": "choline(out) = choline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73516", "l": "UDP(out) + UTP(in) => UDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10934", "l": "2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) => ATP + L-aspartate + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19903", "l": "alpha,beta-didehydrotryptophan + H2O2 => L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74716", "l": "Insulin binds the insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36102", "l": "benzoate + S-adenosyl-L-methionine <=> methyl benzoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55210", "l": "(2R)-hydroxyhexadecanal + phosphoethanolamine => (4R)-hydroxysphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759129", "l": "NFE2L2 binds the PRDX1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73548", "l": "GTP(out) + UTP(in) => GTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46298", "l": "6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18219", "l": "an omega-aminoaldehyde + L-glutamate => 2-oxoglutarate + an alkane-alpha,omega-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50464", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67251", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9609310", "l": "β-blockers bind ADRB1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014587", "l": "Transcription of ROBO3.2 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928620", "l": "PAK1 autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60476", "l": "2 ATP + GTP = 3',3',3'-cAAG + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450187", "l": "TAK1 is activated within the TAK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76472", "l": "AH2 + cob(III)alamin => A + cob(I)alamin + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54079", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + stellata-2,6,19-triene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67620", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35562", "l": "H(+) + menaquinone-7 + NADH <=> menaquinol-7 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38135", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0005243", "l": "gap junction channel activity", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47047", "l": "3-dehydrocarnitine + acetyl-CoA <=> acetoacetate + N,N,N-trimethylglycyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59849", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20452", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 <=> 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77275", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61368", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21147", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51567", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23881", "l": "L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57374", "l": "(6S)-NADPHX => H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.38", "l": "\"plasmepsin I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624668", "l": "CEBPA binds CDKN1A (p21) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47315", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14981", "l": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70438", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29209", "l": "a menaquinone(in) + dimethyl sulfide(out) + H2O(out) => a menaquinol(in) + dimethyl sulfoxide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791035", "l": "Release of NS1 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63565", "l": "apelin-13 + H2O => apelin-12 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689649", "l": "BAP1 binds BRCA1:BARD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64083", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389352", "l": "Translocation of Vav1 to CD28 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61954", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70552", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17289", "l": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.46", "l": "\"fructose-2,6-bisphosphate 2-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37845", "l": "1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004641", "l": "phosphoribosylformylglycinamidine cyclo-ligase activity", "d": ["Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10657", "l": "guanidinoacetate + S-adenosyl-L-methionine => creatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139899", "l": "Sequestration of BAD protein by 14-3-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49540", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18140", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22187", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) <=> acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013108", "l": "GDIs block activation of RHOC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36842", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69754", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654625", "l": "Activated FGFR3 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26482", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": [], "t": []}, {"i": "EC:2.5.1.75", "l": "\"tRNA dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427514", "l": "eNoSC deacetylates histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168640", "l": "Ubiquitinated IkB is degraded (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33339", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797100", "l": "CCNK binds CDK13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48468", "l": "a ganglioside GM1b (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14227", "l": "6-oxohexanoate + H(+) + NADH => 6-hydroxyhexanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45421", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28828", "l": "L-ornithine(out) + putrescine(in) => L-ornithine(in) + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675790", "l": "MTORC1 dissociates from ULK complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0046994", "l": "oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound."], "t": []}, {"i": "EC:1.12.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63554", "l": "angiotensin-(1-5) + L-histidyl-L-proline => angiotensin-(1-7) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42771", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018481", "l": "4-hydroxymuconic-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: <stereo>cis,trans</stereo>-4-hydroxymuconate semialdehyde + H2O + NAD+ = 2 H+ + maleylacetate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212222", "l": "PRC2 recruits DNA methyltransferases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50876", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH = a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.11.1.22", "l": "\"hydroperoxy fatty acid reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377640", "l": "Autophosphorylation of SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23180", "l": "a secondary alcohol + O2 = a ketone + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.18", "l": "\"secondary-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26027", "l": "H2O + N(1)-acetylspermidine + O2 = 3-aminopropanal + H2O2 + N-acetylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12252", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H2O = (E)-coniferol + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.126", "l": "\"coniferin beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25814", "l": "3-acetamidopropanal + H2O2 + putrescine => H2O + N(1)-acetylspermidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080015", "l": "sabinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.4", "l": "\"thymidine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28329", "l": "H2O + wogonin 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + wogonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17195", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693111", "l": "RHOF auto-activates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12009", "l": "[G-protein-coupled receptor] + ATP => [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33434", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate <=> (3E)-2-oxohex-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71940", "l": "2-oxoglutarate(out) + 3 Na(+)(out) => 2-oxoglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.52", "l": "\"preflagellin peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419389", "l": "LPA-binding receptors bind LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70443", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5635854", "l": "GLI2,3 are degraded by the proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64567", "l": "8-epi-ilicicolin H <=> ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69092", "l": "H2O + NAD(+) + pentanal = 2 H(+) + NADH + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44372", "l": "Cr(6+) + 2 NADH + O2 = Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70694", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) <=> chloride(in) + glycine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0051536", "l": "iron-sulfur cluster binding", "d": ["Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71009", "l": "L-phenylalanine(in) + L-tryptophan(out) => L-phenylalanine(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14753", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0052885", "l": "all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity", "d": ["Catalysis of the reaction: H2O + all-trans-retinyl ester = 11-cis-retinol + fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169192", "l": "PTP1B dephosphorylates GHR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003789", "l": "actin filament severing activity", "d": ["Binding to an actin subunit and promoting its dissociation from an actin filament by a local change in actin subunit conformation and orientation, and severing of filaments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062144", "l": "L-propargylglycine synthase activity", "d": ["Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H+ + L-propargylglycine."], "t": []}, {"i": "RHEA:59892", "l": "L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73932", "l": "Resynthesis of excised residue by POLB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60007", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O <=> (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70325", "l": "2-carboxy-L-lyxonolactone => 2,3-dioxo-L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44456", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44331", "l": "1-octanoylglycerol + H2O <=> glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53496", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672961", "l": "PP2A dephosphorylates inactive RAFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034583", "l": "21U-RNA binding", "d": ["Binding to a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35348", "l": "3-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50672", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O = [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008733", "l": "L-arabinose isomerase activity", "d": ["Catalysis of the reaction: L-arabinose = L-ribulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004631", "l": "phosphomevalonate kinase activity", "d": ["Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28380", "l": "ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine => ATP + N(6)-(D-fructosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251942", "l": "Hikeshi binds HSP70s:ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418456", "l": "cGMP is degraded by PDEs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52518", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10 => trans-4-hydroxy-L-proline + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179410", "l": "Association of Nek2A with MCC:APC/C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66935", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate <=> avenanthramide A + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56144", "l": "a quinol + nitrate = a quinone + H2O + nitrite", "d": [], "t": []}, {"i": "EC:1.7.5.1", "l": "\"nitrate reductase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36339", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190519", "l": "Internalization of gap junction plaques (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51310", "l": "H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl-[F-actin] + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64777", "l": "3-sulfanylpentan-1-ol-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29758", "l": "(R)-lipoate(in) <=> (R)-lipoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56509", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74103", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050487", "l": "sulfoacetaldehyde acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.212", "l": "\"hyaluronan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.2", "l": "\"phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018465", "l": "vanillyl-alcohol oxidase activity", "d": ["Catalysis of the reaction: O2 + vanillyl alcohol = H2O2 + vanillin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951727", "l": "cAMP binds PKA tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44614", "l": "2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9793485", "l": "PRKN polyubiquitinates RIPK3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730892", "l": "Recruitment of VAV to p-SLP-76 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63805", "l": "GDP-beta-L-gulose => GDP-beta-L-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17393", "l": "3-maleylpyruvate = 3-fumarylpyruvate", "d": [], "t": []}, {"i": "EC:5.2.1.4", "l": "\"maleylpyruvate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41884", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844440", "l": "NLRP3 activation by elicitor proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33844", "l": "H2O + N-tetracosanoylsphinganine => sphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17390", "l": "D-arabinitol + NAD(+) => D-ribulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831126", "l": "SH forms a pentamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38120", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68684", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34698", "l": "(2E,6E)-farnesyl diphosphate <=> Delta(6)-protoilludene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174255", "l": "Degradation multiubiquitinated Cyclin A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40135", "l": "(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28156", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707856", "l": "PGRMC2:Hemes dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795460", "l": "SGK1 phosphorylates MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080107", "l": "8-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380508", "l": "Translocation of NuMA to the centrosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66176", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46892", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.109", "l": "\"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65728", "l": "2-oxoglutarate + hexyl sulfate + O2 = CO2 + H(+) + hexanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38093", "l": "beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine => delta-tocotrienol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12616", "l": "2 glutathione + L-cystine <=> glutathione disulfide + 2 L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76950", "l": "3-methyl-2-aminobutane + H2O + NADP(+) <=> 3-methylbutan-2-one + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36637", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37747", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603905", "l": "Expression of NLRP3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140741", "l": "WNT5A binds FZD and ROR receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75869", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => 5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879562", "l": "SLCO2B1 has a narrow substrate specificity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351341", "l": "Exocytosis of Proactivator polypeptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951644", "l": "Release of mature NEDD8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008894", "l": "PTPNs gene transcription and translation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139893", "l": "Granzyme-B activates BID by cleavage (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73375", "l": "biotin(out) + 2 Na(+)(out) = biotin(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004982", "l": "N-formyl peptide receptor activity", "d": ["Combining with an N-formyl peptide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62352", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18339", "l": "H2O + psi-UMP => D-ribose 5-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69937", "l": "guanosine(in) + Na(+)(in) => guanosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15012", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633008", "l": "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13206", "l": "a monosaccharide 1-phosphate + H(+) + UTP => a UDP-monosaccharide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20973", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031721", "l": "hemoglobin alpha binding", "d": ["Binding to a hemoglobin alpha chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374899", "l": "Release of noradrenaline  at the synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050509", "l": "N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45785", "l": "2 H2O + phenylpropanonitrile => 3-phenylpropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050412", "l": "cinnamate beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10402", "l": "2-oxoglutaramate + L-alanine => L-glutamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55059", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57702", "l": "5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634228", "l": "TRAF1 is cleaved by caspases (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29856", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine => D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74742", "l": "Phosphorylation of SHC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874193", "l": "CREB3L1 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41321", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41100", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10706", "l": "AMP + diphosphate + L-valyl-tRNA(Val) => ATP + L-valine + tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694409", "l": "Nucleotide exchange on RAB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395517", "l": "NADPH transfers electrons to FDXR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38765", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73897", "l": "ADP + gamma-L-glutamylspermine + H(+) + phosphate => ATP + L-glutamate + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16214", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29178", "l": "2 O2 + ubiquinol-8 <=> 2 H(+) + 2 superoxide + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76343", "l": "(2S)-2-isopropylmalate(in) + sulfate(out) = (2S)-2-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30730", "l": "dATP + pyruvate <=> dADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42218", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31107", "l": "3-phenylpyruvate + O2 = (2-hydroxyphenyl)acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67673", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53367", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) <=> H(+) + NADH + uridine(47) in tRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58492", "l": "ATP + Fe(III)-enterobactin(out) + H2O = ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.17", "l": "\"ABC-type ferric enterobactin transporter\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112510", "l": "IL6ST is tyrosine phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64800", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705926", "l": "AR binds AR agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17475", "l": "7,8-dihydroneopterin 3'-triphosphate + formate + H(+) => GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.46", "l": "\"complement factor D\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426223", "l": "Cation influx mediated by TRPC3/6/7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.24", "l": "\"neopinone isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18811", "l": "aminomalonate + pyruvate => L-alanine + oxomalonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33374", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.5", "l": "\"pyridoxal 5'-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54948", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] = (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840334", "l": "PSAP gets cleaved (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64983", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950328", "l": "Expression of Peptidyl-prolyl cis-trans isomerase A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58203", "l": "2-oxoglutarate + 6-aminohexanoate <=> 6-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870461", "l": "RABGGTA and RABGGTB bind (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561072", "l": "OCT3 mediates renal uptake of organic cations (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72939", "l": "2 Na(+)(out) + propanoate(out) = 2 Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796040", "l": "NFE2L2 dependent KEAP1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65206", "l": "(R)-3-hydroxybutanoate + CoA + H(+) => (3R)-3-hydroxybutanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389857", "l": "Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16148", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45743", "l": "2-oxoglutarate + L-ectoine + O2 <=> 5-hydroxyectoine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51503", "l": "ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111879", "l": "PIP2 hydrolysis (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086410", "l": "CDK1 phosphorylates BORA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75597", "l": "11-hydroxy-12,13-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199935", "l": "MSK1 activates CREB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54787", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide <=> Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10794", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15006", "l": "2-oxoglutarate + gibberellin A1 + O2 => CO2 + gibberellin A8 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858475", "l": "TNFSF9 binds TNFRSF9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653886", "l": "B4GALT1 binds LALBA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16560", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) <=> 2-aminomuconate 6-semialdehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696274", "l": "RND1 binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61195", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34660", "l": "C30 botryococcene + S-adenosyl-L-methionine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019981", "l": "interleukin-6 binding", "d": ["Binding to interleukin-6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033956", "l": "beta-apiosyl-beta-glucosidase activity", "d": ["Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26421", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13088", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O <=> CoA + L-2-acetamido-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65175", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O <=> (3Z,5E)-dodecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22521", "l": "all-trans-retinal + H2O + O2 => all-trans-retinoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58414", "l": "H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin] => 3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917696", "l": "Cargo Sequestration (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102449", "l": "kaempferol 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferol oxoanion + S-adenosyl-L-methionine = 3-O-methylkaempferol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57066", "l": "D-apionate + H(+) => D-apionolactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112436", "l": "Formation of Elongin complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430308", "l": "PARVB interacts with Alpha-actinin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655351", "l": "Activated FGFR4 mutants bind FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55738", "l": "[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44841", "l": "(R)-carnitine + octadecanoyl-CoA => CoA + O-octadecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67318", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10010", "l": "[protein]-disulfide + an alcohol + H2O => [protein]-dithiol + a hydroperoxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42281", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52608", "l": "2-hydroxybutanoate + NADP(+) = 2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31165", "l": "(2E)-hexadecenoyl-CoA + H2O => (3S)-hydroxyhexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69140", "l": "RPA binds to the Flap (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43488", "l": "7(1)-hydroxychlorophyll a + NAD(+) = chlorophyll b + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.5.3", "l": "\"formate dehydrogenase-N\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77314", "l": "glyoxylate + N(omega),N(omega)-dimethyl-L-arginine <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63563", "l": "angiotensin I + H2O <=> angiotensin II + L-histidyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939201", "l": "ESR dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20508", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid <=> 5-oxo-L-proline + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16791", "l": "a 2-oxocarboxylate + H2O2 => a (2S)-2-hydroxycarboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28010", "l": "propanoyl-CoA + succinate = propanoate + succinyl-CoA", "d": [], "t": []}, {"i": "EC:2.8.3.27", "l": "\"propanoyl-CoA:succinate CoA transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651789", "l": "LIG1 bound to POLB ligates SSB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050369", "l": "[tyrosine 3-monooxygenase] kinase activity", "d": ["Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716913", "l": "ESR1 binds ESR1 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13707", "l": "alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP => alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2564824", "l": "NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139905", "l": "Translocation of activated BAD protein to mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685939", "l": "3a localizes to the cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45129", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871266", "l": "YAP1 binds TEAD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429415", "l": "SYK binds to integrin alphaIIb beta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65002", "l": "AMP + H(+) + octanoyl-[ACP] => holo-[ACP] + octanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38239", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40743", "l": "(20S)-ginsenoside Rd + 2 H2O = (20S)-ginsenoside C-K + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198983", "l": "NKG2D homodimer interacting with ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46856", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000246", "l": "delta24(24-1) sterol reductase activity", "d": ["Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086077", "l": "gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606789", "l": "ARSB hydrolyses DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24186", "l": "3,4-dihydroxybenzoate + CO2 => 4,5-dihydroxyphthalate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22983", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] <=> a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389463", "l": "Proteinase-activated receptors can bind thrombin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790038", "l": "Expression of HSP90B1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23374", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31744", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine => a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61971", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30645", "l": "hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioinosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65554", "l": "an N-acyl-sphingoid base + lactose => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0071568", "l": "UFM1 transferase activity", "d": ["Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450348", "l": "Activated human JNKs migrate to nucleoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015594", "l": "ABC-type putrescine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693536", "l": "ATM phosphorylates MDC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33020", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA => (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509827", "l": "ITPA hydrolyses ITP to IMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29425", "l": "ADP + H(+) + triphosphate => ATP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44493", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761047", "l": "HEYL binds CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56576", "l": "a globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine = a globoside Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40929", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38736", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23894", "l": "3-nitroacrylate + H(+) + NADPH => 3-nitropropanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65171", "l": "AH2 + O2 + preaustinoid A <=> A + H2O + preaustinoid A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51115", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086057", "l": "voltage-gated calcium channel activity involved in bundle of His cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163310", "l": "TFAM binds to mitochondrial promoters (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52896", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin = 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.12", "l": "\"Ni-sirohydrochlorin a,c-diamide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77269", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31889", "l": "tirucalladienol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22183", "l": "(S)-norreticuline + S-adenosyl-L-methionine <=> (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67303", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one <=> 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76391", "l": "glycylglycylglycine(out) + n H(+)(out) = glycylglycylglycine(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912734", "l": "CBL:CRKL binds RAPGEF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74649", "l": "GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate => GTP + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647631", "l": "GSDMD (1-275) binds PIPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44052", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29333", "l": "fumarate(out) + 2 H(+)(out) => fumarate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16295", "l": "(2S)-2-isopropylmalate => 2-isopropylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362416", "l": "Frataxin binds iron (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60018", "l": "diphosphate + sesquisabinene B => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28056", "l": "formate + propanoyl-CoA => 2-oxobutanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48813", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784598", "l": "NPPA(124-151) binds NPR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450325", "l": "c-FOS activation by phospho ERK1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44233", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56174", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + H2O => FMN + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45196", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.245", "l": "\"5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70059", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51624", "l": "formate + GTP + H(+) = CO2 + dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49466", "l": "CO2 + resorcinol => 2,6-dihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29746", "l": "2-phenylethylamine(in) <=> 2-phenylethylamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53010", "l": "di-trans,poly-cis-polyprenyl diphosphate + n diphosphate => (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75190", "l": "2,5-dihydroxybenzoyl-CoA + H2O <=> 2,5-dihydroxybenzoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25997", "l": "H2O + N(1)-acetylspermine + O2 => H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46630", "l": "androst-5-en-3beta,17beta-diol + NADP(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102835", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42504", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11583", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.20", "l": "\"deacetoxyvindoline 4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018592", "l": "4-nitrocatechol 4-monooxygenase activity", "d": ["Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59379", "l": "4-amino-4-deoxychorismate <=> 4-amino-4-deoxyprephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951486", "l": "CD46 binds C4b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24448", "l": "enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51095", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034009", "l": "isoprene synthase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21466", "l": "carbonyl sulfide + NH4(+) => 2 H(+) + H2O + thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53935", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57864", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.165", "l": "\"indole-3-carbonyl nitrile 4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62195", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13387", "l": "2-undecanone + CO2 => 3-oxododecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69748", "l": "(indol-3-yl)acetate + succinyl-CoA => (indol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757256", "l": "MCM3 binds MCM5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660013", "l": "Defective RPIA does not isomerize RU5P to R5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24672", "l": "H(+) + NADH + xanthine => H2O + hypoxanthine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726509", "l": "NR3C2 binds fludrocortisone (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785181", "l": "LMF1,2 bind LIPC dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47650", "l": "phosphate + ribitol => D-ribitol 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690023", "l": "NUBPL binds 4Fe-4S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60167", "l": "a guanosine in RNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20207", "l": "cycasin + H(+) + UDP => methylazoxymethanol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033992", "l": "1,5-anhydro-D-fructose dehydratase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28448", "l": "1-deoxy-D-xylulose(out) => 1-deoxy-D-xylulose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0034235", "l": "GPI anchor binding", "d": ["Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57651", "l": "S-adenosyl-L-methionine + trichosetin <=> equisetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532603", "l": "Nephrin mediated activation of N-WASP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17001", "l": "amidinoproclavaminate + H2O = proclavaminate + urea", "d": [], "t": []}, {"i": "EC:3.5.3.22", "l": "\"proclavaminate amidinohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77495", "l": "acetophenone + hydrogen cyanide = (2S)-2-hydroxy-2-phenylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51514", "l": "NH4(+) + oxalate => H2O + oxamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61523", "l": "AH2 + dopamine <=> 3-tyramine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786621", "l": "TRMT10A methylates guanosine-9 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12598", "l": "acetyl-CoA + phosphinothricin => CoA + H(+) + N-acetylphosphinothricin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801195", "l": "STEAP3 binds BNIP3L (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40254", "l": "4-O-methylrhodomycin D + H2O <=> 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174202", "l": "Degradation of multiubiquitinated Securin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047417", "l": "N-carbamoyl-D-amino acid hydrolase activity", "d": ["Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624948", "l": "KIF17 enters the cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54306", "l": "n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69086", "l": "acrylate + 2 H(+) + NADH => acrolein + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854222", "l": "TBC1D3 associates with RAB5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46852", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31824", "l": "(2E,6E)-farnesyl diphosphate + H2O => cubebol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40577", "l": "CoA + glutarate + H(+) => glutaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33983", "l": "(+)-copalyl diphosphate = diphosphate + miltiradiene", "d": [], "t": []}, {"i": "EC:4.2.3.131", "l": "\"miltiradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62736", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77341", "l": "2-oxobutanoate + glycine => (2S)-2-aminobutanoate + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33644", "l": "(9Z)-tetradecenoate + ATP + CoA => (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29944", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) => 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72817", "l": "L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0046572", "l": "versicolorin B synthase activity", "d": ["Catalysis of the reaction: versiconal = versicolorin B + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047258", "l": "sphingosine beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: sphingosine + UDP-D-galactose = H+ + psychosine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68426", "l": "(3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R)-3-hydroxy-10'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60169", "l": "a fatty acid + ATP => a fatty acyl monophosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28385", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine <=> D-glucose 6-phosphate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75770", "l": "(9Z)-hexadecenoate + H2O <=> 10-hydroxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196857", "l": "PANK2 phosphorylates PanK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102197", "l": "vinylacetate caboxylester hydrolase activity", "d": ["Catalysis of the reaction: but-3-enoate + H2O = allyl alcohol + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61207", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal <=> H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006850", "l": "IL21 receptor JAK phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75702", "l": "2 glutathione + NAD(+) <=> glutathione disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433501", "l": "Interaction of other adapter proteins with p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952101", "l": "p14-ARF transcription is stimulated by RUNX proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757578", "l": "ALB binds PREDN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139893", "l": "Granzyme-B activates BID by cleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174438", "l": "Formation of the Flap Intermediate on the C-strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11675", "l": "chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14689", "l": "4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.9", "l": "\"4-chlorophenylacetate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.11.1.-", "l": "\"Acting on carbon-phosphorus bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052912", "l": "23S rRNA (guanine(748)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66118", "l": "(2S)-2-aminobutanoate + 2-oxoglutaramate => 2-oxobutanoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15244", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73921", "l": "H2O + norlichexanthone => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050593", "l": "N-methylcoclaurine 3'-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-N-methylcoclaurine + H+ + NADPH + O2 = (S)-3'-hydroxy-N-methylcoclaurine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862700", "l": "CMKLR1 binds Resolvin E1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481009", "l": "Exocytosis of platelet dense granule content (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.20", "l": "\"Delta(7)-sterol 5(6)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14581", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH = 2 L-ascorbate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.6.5.4", "l": "\"monodehydroascorbate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21703", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5220959", "l": "TDG excises 5-formylcytosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.-", "l": "\"With NADH or NADPH as one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201639", "l": "Caspase-mediated cleavage of GAS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.-", "l": "\"Hydro-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002466", "l": "Formation of allysine by LOX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:1905538", "l": "polysome binding", "d": ["Binding to a polysome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62800", "l": "2 7-demethylsiderin + NADPH + O2 = 2 H2O + NADP(+) + orlandin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49409", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate => [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68603", "l": "ORC5 binds ORC2:ORC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25842", "l": "5-dehydro-2-deoxy-D-gluconate => 5-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43619", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234179", "l": "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77252", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP-alpha-D-mannose => alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016972", "l": "thiol oxidase activity", "d": ["Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77637", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72352", "l": "glutarate(in) + glycocholate(out) => glutarate(out) + glycocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17337", "l": "catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.2", "l": "\"catechol 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43998", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate => 2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20122", "l": "ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35151", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) = (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57141", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373707", "l": "Netrin-1 induced DCC clustering (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10909", "l": "3'-phosphoadenylyl sulfate + glycolithocholate => adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944263", "l": "Association of procollagen type II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70476", "l": "2 S-adenosyl-L-methionine + sphing-4-enine => 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41954", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51658", "l": "keto-D-fructuronate => keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41161", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34558", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44067", "l": "hexadecanoyl-CoA + octan-1-ol <=> CoA + octyl hexadecanoyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29341", "l": "(S)-malate(out) + 2 H(+)(out) => (S)-malate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009817", "l": "Acitretin binds to RAR:RXR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374173", "l": "AGT(34-41) binds to AGTR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940959", "l": "Neurolysin degrades neurotensin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21227", "l": "CDP-choline + sphing-4-enine <=> CMP + H(+) + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33756", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654651", "l": "Activated FGFR4 binds FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29358", "l": "dUMP + H2O <=> 2'-deoxyuridine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026008", "l": "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983061", "l": "TSLP binds CRLF2:IL7R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56854", "l": "H(+) + S-adenosyl-L-homocysteine + toxoflavin => reumycin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615556", "l": "Defective POMT2 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38153", "l": "CO2 + H(+) + hydrogen sulfide => carbonyl sulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48275", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70547", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53927", "l": "a secondary amine + S-adenosyl-L-methionine <=> a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467811", "l": "Separation of sister chromatids (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618093", "l": "ATP hydrolysis by HSP90 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73870", "l": "serotonin(out) <=> serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419268", "l": "TUFM binds GTP displacing TSFM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22523", "l": "all-trans-retinal + H2O + O2 <=> all-trans-retinoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31851", "l": "(S)-2,3-epoxysqualene = parkeol", "d": [], "t": []}, {"i": "EC:5.4.99.47", "l": "\"parkeol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47777", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51390", "l": "CoA + H(+) + N-acetyl-dopamine => acetyl-CoA + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18683", "l": "phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668831", "l": "CST complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49049", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977301", "l": "Histidine is decarboxylated to histamine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33975", "l": "DIMBOA beta-D-glucoside + H2O = D-glucose + DIMBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64343", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one <=> 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18490", "l": "cyanate + H(+) + hydrogencarbonate => carbamate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70175", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate = alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}, {"i": "EC:2.4.1.388", "l": "\"glucosylgalactose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38121", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649733", "l": "mature p21 RAS binds GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102920", "l": "acyl coenzyme A: isopenicillin N acyltransferase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O = H+ + coenzyme A + penicillin K + L-2-aminoadipate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39940", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10268", "l": "2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.20", "l": "\"2-dehydro-3-deoxyglucarate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43333", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31830", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-gamma-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71458", "l": "goralatide + H2O <=> L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752980", "l": "RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179410", "l": "Association of Nek2A with MCC:APC/C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19250", "l": "glyoxylate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56694", "l": "4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27325", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40325", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75934", "l": "H2O + taurocyamine <=> taurine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102602", "l": "cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity", "d": ["Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186765", "l": "PLC-gamma binds to the active receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950387", "l": "CANX binds EBI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50362", "l": "benzoyl cyanide + H2O2 => (R)-mandelonitrile + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18593", "l": "sphinganine 1-phosphate = hexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694409", "l": "Nucleotide exchange on RAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.6", "l": "\"coagulation factor Xa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58855", "l": "(6E)-8-oxogeraniol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855168", "l": "I(1,3,4,5)P4 transports from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089971", "l": "Secretion of collagens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23071", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA <=> 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112434", "l": "Formation of DSIF complex  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75854", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54519", "l": "8-hydroxycopalyl diphosphate <=> (13R)-manoyl oxide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005463", "l": "UDP-N-acetylgalactosamine transmembrane transporter activity", "d": ["Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34606", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15388", "l": "L-asparagine <=> 3-cyano-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22775", "l": "L-fuconate <=> 2-dehydro-3-deoxy-L-fuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606349", "l": "Mis18 complex binds the centromere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70073", "l": "(22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sitosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008885", "l": "glutathionylspermidine synthase activity", "d": ["Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937989", "l": "RUNX1 binds PRC1 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44962", "l": "decanoyl-CoA + NADP(+) => (2E)-decenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614591", "l": "Excess cysteine yields lanthionine and H2S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59615", "l": "beta-alanyl-L-ornithine + H2O <=> beta-alanine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23118", "l": "4-hydroxybenzoyl-CoA + AMP + diphosphate => 4-hydroxybenzoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928616", "l": "Activated ROCK phosphorylates MRLCs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044590", "l": "iron-sulfur-molybdenum cofactor binding", "d": ["Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48602", "l": "[protein-PII]-L-tyrosine + H(+) + UMP => [protein-PII]-uridylyl-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032478", "l": "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25852", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.5", "l": "\"acyl-CoA 11-(Z)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22270", "l": "ADP + H(+) + streptomycin 6-phosphate => ATP + streptomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952996", "l": "E2F7 forms homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840334", "l": "PSAP gets cleaved (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140294", "l": "NAD DNA ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32013", "l": "(+)-T-muurolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.68", "l": "\"isoamylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50577", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164834", "l": "Enzyme-bound ATP is released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46264", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28461", "l": "biotin(in) <=> biotin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26340", "l": "L-homocysteine + S-methyl-L-methionine <=> H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.4.5", "l": "\"tetrachlorohydroquinone reductive dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52256", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16716", "l": "H2O + S-succinylglutathione <=> glutathione + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164845", "l": "Suicidal integration leading to inverted circle formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983150", "l": "Proteasomal cleavage of substrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019769", "l": "low-affinity IgE receptor activity", "d": ["Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004533", "l": "exoribonuclease H activity", "d": ["Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10829", "l": "anthranilate + ATP + CoA => AMP + anthraniloyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686013", "l": "Nsp3:nsp4 binds to nsp6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65832", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25960", "l": "benzoin + NADP(+) = benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74438", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70021", "l": "7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.-.-", "l": "\"Transferring alkyl or aryl groups, other than methyl groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61149", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43752", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": [], "t": []}, {"i": "EC:2.3.1.267", "l": "\"[ribosomal protein uS5]-alanine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50079", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938440", "l": "miR-17 binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33418", "l": "bornane-2,6-dione + H2O <=> [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30911", "l": "a sphingomyelin + H2O = a carboxylate + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045485", "l": "omega-6 fatty acid desaturase activity", "d": ["Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172678", "l": "PHF8 demethylates histone H4K20me1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75642", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate <=> (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67571", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate <=> adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835454", "l": "DNAJC3 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11022", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702818", "l": "CALCR binds erenumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74361", "l": "coproporphyrin I(in) => coproporphyrin I(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57393", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine => 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59266", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73739", "l": "dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20580", "l": "3-hydroxyaminophenol <=> aminohydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047559", "l": "3-dehydro-L-gulonate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420243", "l": "GHRH receptor binds GHRH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905948", "l": "ABC-type 3',5'-cyclic GMP transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + 3',5'-cyclic GMP(in) = ADP + phosphate + 3',5'-cyclic GMP(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30006", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354060", "l": "Translocation of RIAM to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35939", "l": "brevianamide F + dimethylallyl diphosphate = diphosphate + tryprostatin B", "d": [], "t": []}, {"i": "EC:2.5.1.106", "l": "\"tryprostatin B synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665748", "l": "FMNL2 binds RHOC:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.255", "l": "\"protein O-GlcNAc transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047946", "l": "glutamine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55746", "l": "coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n) => coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670428", "l": "KIT mutants bind GRB2-SOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14650", "l": "demethyllactenocin + dTDP-beta-L-mycarose => demethylmacrocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16574", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33136", "l": "malonate(in) + Na(+)(in) => malonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74913", "l": "a (2E)-enoyl-[ACP] + AMP + diphosphate => a (2E)-enoyl fatty acid + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29644", "l": "D-maltoheptaose + H2O => alpha-D-glucose + D-maltohexaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43231", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23935", "l": "an N-acyl-D-glucosamine 6-phosphate <=> an N-acyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047284", "l": "dolichyl-xylosyl-phosphate-protein xylosyltransferase activity", "d": ["Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23907", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] <=> 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74991", "l": "deoxyerythrostominone(in) = deoxyerythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50472", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA = (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.262", "l": "\"anthraniloyl-CoA anthraniloyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170846", "l": "TGFBR2 recruits TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73829", "l": "an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15314", "l": "ethanolamine => acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20557", "l": "2 H(+) + H2O + urea = CO2 + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.5", "l": "\"urease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42918", "l": "2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805479", "l": "TP53RK phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28844", "l": "choline(in) + H(+)(in) => choline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047669", "l": "amylosucrase activity", "d": ["Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047383", "l": "guanidinodeoxy-scyllo-inositol-4-phosphatase activity", "d": ["Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0004935", "l": "adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23779", "l": "ATP + L-aspartate <=> 4-phospho-L-aspartate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33543", "l": "ergosteryl palmitate + H2O = ergosterol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77741", "l": "a 1-acyl-sn-glycero-3-phospholipid + a triacylglycerol => a 1,2-diacylglycerol + a glycerophospholipid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22239", "l": "2-deoxy-D-glucose 6-phosphate + H2O <=> 2-deoxy-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033739", "l": "preQ1 synthase activity", "d": ["Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60312", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215295", "l": "USP7 deubiquitinates MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004499", "l": "N,N-dimethylaniline monooxygenase activity", "d": ["Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23554", "l": "2-hydroxy-2-methylpropanal + H(+) + NADH => 2-methylpropane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54767", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004125", "l": "L-seryl-tRNA(Sec) selenium transferase activity", "d": ["Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33635", "l": "ATP + CoA + docosanoate = AMP + diphosphate + docosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047223", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41993", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29193", "l": "iminosuccinate + menaquinol-8 => L-aspartate + menaquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37179", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55099", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O <=> (3S)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42133", "l": "isonocardicin C => nocardicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610720", "l": "PKA phosphorylates GLI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75578", "l": "11-O-acetylcyathatriol + A <=> 11-O-acetylcyathin A3 + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852331", "l": "GTSE1 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783880", "l": "PIPOX oxidises PPCA to P6C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666008", "l": "SCAI binds SRF:MKL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18348", "l": "a cis-3-alkyl-4-alkyloxetan-2-one <=> a cis-alkene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948757", "l": "AKT phosphorylates MKRN1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25162", "l": "L-glutamate + L-glutamate 5-semialdehyde => 2-oxoglutarate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28894", "l": "H(+)(in) + putrescine(in) <=> H(+)(out) + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417890", "l": "P2Y5 receptor can bind to LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57856", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.61", "l": "\"feruloyl-CoA 6-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37920", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60095", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77608", "l": "Binding of A1CF to stem-looped RNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45137", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18292", "l": "(S,S)-tartrate <=> H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55797", "l": "H(+) + NADH + O2 + phenol => H2O + hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75423", "l": "(R,S)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003919", "l": "FMN adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + FMN = diphosphate + FAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61073", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA => (-)-(R)-19-O-acetyltabersonine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375395", "l": "C5a receptor binds C5a anaphylatoxin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72480", "l": "citrate(out) + trans-aconitate(in) => citrate(in) + trans-aconitate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67353", "l": "malonyl-CoA + rhaponticin => 6-O-malonyl-rhaponticin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71456", "l": "goralatide + H2O => L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858475", "l": "ppDVL recruits RAC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68514", "l": "alpha-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18371", "l": "dihydroxyacetone phosphate + H2O2 => O2 + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49440", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA = (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": [], "t": []}, {"i": "EC:2.8.3.24", "l": "\"(R)-2-hydroxy-4-methylpentanoate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165195", "l": "GTP loading by Rheb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30041", "l": "benzene-1,2,4-triol + CO2 + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047344", "l": "glucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866277", "l": "AP-2 directly binds some endocytic cargo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.-", "l": "\"Endodeoxyribonucleases producing 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14496", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] <=> ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50321", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51845", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788628", "l": "p-Y-STATs dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691154", "l": "HFE binds TFRC dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33642", "l": "ATP + CoA + tetracosanoate <=> AMP + diphosphate + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36100", "l": "benzoate + S-adenosyl-L-methionine => methyl benzoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72941", "l": "2 Na(+)(in) + propanoate(in) => 2 Na(+)(out) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51782", "l": "deoxyadlupulone + diphosphate => 4-prenylphlormethylbutanophenone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33684", "l": "H(+) + L-serine + octadecanoyl-CoA => 3-oxoeicosasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60173", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10647", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016669", "l": "oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome."], "t": []}, {"i": "EC:1.8.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40711", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28893", "l": "H(+)(out) + putrescine(out) => H(+)(in) + putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014456", "l": "GDIs block activation of RHOG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13512", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852337", "l": "GTSE1 binds TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22339", "l": "glycine betaine + L-homocysteine <=> L-methionine + N,N-dimethylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72185", "l": "mRNA polyadenylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52484", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59626", "l": "4-aminobutanoate + L-ornithine => H2O + N(2)-(4-aminobutanoyl)-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77484", "l": "heptan-2-one + hydrogen cyanide => (2S)-2-hydroxy-2-methylheptanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835944", "l": "ADAR1 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20822", "l": "choline + H(+) + sulfate => choline sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442749", "l": "CaMKK autophosphorylates in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76151", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864395", "l": "TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56033", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74302", "l": "D-isoleucine(out) + D-serine(in) <=> D-isoleucine(in) + D-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11850", "l": "[thioredoxin]-dithiol + glycine betaine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018758", "l": "RHOH binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72070", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate <=> ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16931", "l": "2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine => 2 benzoyl-CoA + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70423", "l": "an acyl-CoA + H2O = a carboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23841", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0141110", "l": "transporter inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a transporter."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875816", "l": "STAT3 binds activated MET receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0030554", "l": "adenyl nucleotide binding", "d": ["Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.60", "l": "\"scutelarin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036311", "l": "chitin disaccharide deacetylase activity", "d": ["Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102506", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42301", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24426", "l": "glutathione disulfide + L-ascorbate => 2 glutathione + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023351", "l": "DLL1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30483", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62041", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate => N-octanoylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676257", "l": "Formation of the SET1A complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373746", "l": "SEMA4D interacts with CD45 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483186", "l": "PC is converted to PS by PTDSS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58408", "l": "NADP(+) + undecan-1-ol = H(+) + NADPH + undecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62589", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) => 4-hydroxybenzyl alcohol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13864", "l": "D-xylose + NAD(+) <=> D-xylono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52621", "l": "3-methylbutanoyl-CoA => 2,2-dimethylpropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33673", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2 => an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685230", "l": "CHEK1 phosphorylates RAD51 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444171", "l": "Receptor FFAR2 binds carboxylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34970", "l": "sn-glycerol 3-phosphate(in) <=> sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336182", "l": "GPR37 binds prosaptide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57570", "l": "7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985343", "l": "RUNX2 binds SOX9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39730", "l": "a sphingomyelin(in) <=> a sphingomyelin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16752", "l": "H2O + phosphonoacetate <=> acetate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030348", "l": "syntaxin-3 binding", "d": ["Binding to a syntaxin-3 SNAP receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62893", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38673", "l": "sphinganine 1-phosphate(out) => sphinganine 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45447", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40541", "l": "H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24897", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine <=> isopimpinellin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34645", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37644", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54365", "l": "2 acetaldehyde => acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68860", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH = 7beta-25-dihydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.88", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140107", "l": "high-affinity potassium ion transmembrane transporter activity", "d": ["Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62409", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine => 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18695", "l": "6-aminopenicillanate + a carboxylate => a penicillin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247843", "l": "secretion of WNT ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418091", "l": "F2R binds ARRB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761186", "l": "Expression of OSR1 in intermediate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34403", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 = (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": [], "t": []}, {"i": "EC:1.13.11.69", "l": "\"carlactone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26350", "l": "beta-L-galactose 1-phosphate + H2O => L-galactose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939670", "l": "RUNX2:CBFB binds the ITGA5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75080", "l": "Formation of AT-AC A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63882", "l": "cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur => 2 Fe(III)-[cytochrome c] + H2O + thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50076", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.24", "l": "\"cathepsin T\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24869", "l": "5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11522", "l": "(-)-menthyl beta-D-glucoside + H(+) + UDP => (-)-menthol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39778", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222237", "l": "SMYD2 methylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13240", "l": "D-fructose 6-phosphate + L-glutamine <=> D-glucosamine 6-phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52795", "l": "chlorophyllide a + 2 H(+) <=> Mg(2+) + pheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662786", "l": "FURIN cleaves ADAM17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12554", "l": "(E)-pinosylvin + 4 CO2 + 4 CoA => (E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24760", "l": "H(+) + L-dopa + NADH = 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.22", "l": "\"3,4-dihydroxyphenylalanine reductive deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990525", "l": "BIR domain binding", "d": ["Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.148", "l": "\"estradiol 17alpha-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63290", "l": "9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936380", "l": "Interaction of PIN1 with p-IRF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38478", "l": "L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48696", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190168", "l": "HMBL spontaneously transforms to URO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160117", "l": "tRNA (guanine(6)-N2)-methyltransferase activity", "d": ["Catalysis of the reaction: guanosine(6) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38916", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36498", "l": "alpha-D-glucose + ATP <=> ADP + alpha-D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38131", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64363", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 <=> (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47240", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31863", "l": "(S)-2,3-epoxysqualene = friedelin", "d": [], "t": []}, {"i": "EC:5.4.99.50", "l": "\"friedelin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912409", "l": "NOTCH3 mRNA translation controlled by miRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848077", "l": "PTK6 phosphorylates STAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57969", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14464", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose <=> (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985799", "l": "SLIT1 binds ROBO1,(ROBO2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12437", "l": "(E)-caffeoyl-CoA + putrescine => CoA + H(+) + N-caffeoylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102688", "l": "dihydrozeatin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin = H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70805", "l": "4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18512", "l": "H(+) + H2O2 + NADH <=> 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52106", "l": "an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+) => a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199910", "l": "MSK1 activates ATF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796068", "l": "AcK-NFE2L2 binds the ATF4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50343", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone <=> 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37483", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189406", "l": "4 PBGs bind to form HMB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033419", "l": "CUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250264", "l": "TXNIP binds reduced thioredoxin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72617", "l": "H(+)(in) + L-alanyl-L-valine(in) => H(+)(out) + L-alanyl-L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-532549", "l": "MPI isomerises Fru6P to Man6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57115", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25921", "l": "A + H2O + quinolin-7-ol => 7-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679205", "l": "ULK1 phosphorylates Beclin-1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617672", "l": "HOXB3 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005175", "l": "CD27 receptor binding", "d": ["Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016515", "l": "interleukin-13 receptor activity", "d": ["Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799332", "l": "ATR phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29397", "l": "diphosphate + H(+) + UMP => H2O + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23434", "l": "(4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29413", "l": "glycolate(out) + H(+)(out) => glycolate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296043", "l": "Activation of HCN channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36566", "l": "GDP-beta-L-colitose + NADP(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211467", "l": "HNF1A-dependent synthesis of HNF4G protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57685", "l": "4-hydroxyestrone + NH4(+) + O2 => 2 H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187575", "l": "Ubiquitination of phospho-p27/p21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690873", "l": "ACO1 binds 4Fe-4S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50430", "l": "dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine => methanethiol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63979", "l": "A + dihydropyriculariol <=> AH2 + pyriculariol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51293", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252072", "l": "AZGP1 binds PIP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41258", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374701", "l": "Phosphorylation of DCC by Fyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625092", "l": "ABCA6 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76434", "l": "Na(+)(out) + NH4(+)(in) <=> Na(+)(in) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59074", "l": "5'-deoxyadenosine + A + cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109817", "l": "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74830", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) <=> UDP-alpha-D-galacturonate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990119", "l": "RNA helicase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an RNA helicase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68215", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40554", "l": "demethylphylloquinol + S-adenosyl-L-methionine <=> H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49252", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.202", "l": "\"protein-N(pi)-phosphohistidine--D-fructose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21636", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.126", "l": "\"hydroxycinnamate 4-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38973", "l": "(2E)-octadecenoyl-CoA + H2O2 => O2 + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16224", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32355", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + 2 UDP", "d": [], "t": []}, {"i": "EC:2.4.1.249", "l": "\"delphinidin 3',5'-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129353", "l": "Tropoelastin associates with microfibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57826", "l": "2-deoxy-D-ribose 5-phosphate + adenine => dAMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21261", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57082", "l": "1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione => glutathione + S-methyl-1-thio-D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13870", "l": "NAD(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35803", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36603", "l": "2-oxoglutarate + L-enduracididine + O2 = (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.40", "l": "\"enduracididine beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089971", "l": "Secretion of collagens (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62056", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39579", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA = (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43152", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.220", "l": "\"tRNA (adenine(58)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58279", "l": "6 ATP <=> cyclic hexaadenylate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139918", "l": "Phosphorylation of BIM by JNK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23502", "l": "3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140347", "l": "N-retinylidene-phosphatidylethanolamine flippase activity", "d": ["Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37430", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50081", "l": "ATP + H2O + taurodeoxycholate(in) => ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733969", "l": "Bile salts dissociate from FABP6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76741", "l": "5-dodecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecane + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62822", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O => 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35541", "l": "albonoursin + H2O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64295", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH <=> (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11460", "l": "ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74782", "l": "laricitrin + S-adenosyl-L-methionine <=> 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18064", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran <=> methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75779", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O = (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391941", "l": "BLT receptors can bind LTB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68381", "l": "3-hydroxypyruvate + L-asparagine => 2-oxosuccinamate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018747", "l": "RHOQ GEFs activate RHOQ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21977", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite => [thioredoxin]-dithiol + adenosine 5'-phosphosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0036440", "l": "citrate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649686", "l": "NEIL2 recognizes and binds 5-OHU-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51794", "l": "2,3-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53857", "l": "NADP(+) + ursocholate => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047888", "l": "fatty acid peroxidase activity", "d": ["Catalysis of the reaction: 2 H2O2 + H+ + palmitate = CO2 + 3 H2O + pentadecanal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55424", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] = (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.59", "l": "\"dimethylnonatriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169406", "l": "ISGylation of host proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213466", "l": "RIPK3 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56110", "l": "2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => genistein + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016977", "l": "chitosanase activity", "d": ["Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65500", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:4.1.99.26", "l": "\"3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018453", "l": "2-hydroxytetrahydrofuran dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.6", "l": "\"chymopapain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684301", "l": "mRNA1 is translated to pp1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203979", "l": "Coat Assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46804", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.317", "l": "\"sphingolipid C(9)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35808", "l": "2-dehydro-3-deoxy-D-arabinonate => 2,5-dioxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904493", "l": "tetrahydrofolyl-poly(glutamate) polymer binding", "d": ["Binding to tetrahydrofolyl-poly(glutamate) polymer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65779", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21024", "l": "CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.1.17", "l": "\"glyoxylate dehydrogenase (acylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102884", "l": "alpha-zingiberene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = zingiberene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008736", "l": "L-fucose isomerase activity", "d": ["Catalysis of the reaction: L-fucose = L-fuculose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42815", "l": "cholesterol + octadecanoyl-CoA <=> cholesteryl octadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25376", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA => a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27716", "l": "guanosine + phosphate => GMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047749", "l": "cholestanetriol 26-monooxygenase activity", "d": ["Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32288", "l": "(2R,3S)-3-isopropylmalate => (2S)-2-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66424", "l": "ATP + H2O + leukotriene B4(in) = ADP + H(+) + leukotriene B4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72722", "l": "eIF2 activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102370", "l": "lupeol 28-monooxygenase activity", "d": ["Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ = betulin + NADP(3-) + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995330", "l": "COX10 transforms heme to heme O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13050", "l": "D-glucuronate => D-fructuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2272753", "l": "Interaction of DAP12 and KIR2DS4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654603", "l": "Activated FGFR2 binds FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033930", "l": "keratan-sulfate endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2219524", "l": "PDPK1 binds PIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709109", "l": "DHFR dimer binds DHFR inhibitors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62462", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222020", "l": "NUAK1 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30095", "l": "(S)-malate + a menaquinone = a menaquinol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24155", "l": "adenosine 5'-phosphosulfate + ATP <=> 3'-phosphoadenylyl sulfate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41444", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.13.11.78", "l": "\"2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47242", "l": "(2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25120", "l": "H2O + L-lysine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.18", "l": "\"meprin A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64549", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18018", "l": "H(+) + indole-3-pyruvate => CO2 + indole-3-acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17433", "l": "A + choline = AH2 + betaine aldehyde", "d": [], "t": []}, {"i": "EC:1.1.99.1", "l": "\"choline dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41207", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140929", "l": "mannose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-mannose(out) + Na+(out) = D-mannose(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951500", "l": "Dissociation of CANX from nonameric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64809", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine => CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49931", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51219", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one <=> adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73228", "l": "(3R)-citramalate(in) + sulfate(out) => (3R)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70045", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone => 6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961665", "l": "PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53399", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378975", "l": "Follitropin is a heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63357", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76156", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47926", "l": "(2S)-3-sulfolactaldehyde + pyruvate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202164", "l": "Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016494", "l": "C-X-C chemokine receptor activity", "d": ["Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14359", "l": "ADP + FMN + H(+) => ATP + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49003", "l": "aurachin C + H(+) + NADH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687088", "l": "PKA phosphorylates MAPKAPK5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782820", "l": "USP17 deubiquitinates SUDS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727919", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44069", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39059", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62666", "l": "deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine => (2'R)-atrovenetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24338", "l": "AMP + an acyl-CoA + diphosphate => a carboxylate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65918", "l": "H2O + kynurenate + L-alanine => L-kynurenine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34817", "l": "curcumin + 2 H(+) + 2 NADPH => 2 NADP(+) + tetrahydrocurcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26273", "l": "Co-precorrin-3 + S-adenosyl-L-methionine = Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014456", "l": "GDIs block activation of RHOG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32613", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-hydroxygeranial + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70867", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) = L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33265", "l": "(E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37943", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51336", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062104", "l": "pumilio-response element binding", "d": ["Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21340", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin", "d": [], "t": []}, {"i": "EC:1.13.11.43", "l": "\"lignostilbene alphabeta-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75706", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate <=> 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853405", "l": "TPX2 binds AURKA at centrosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51305", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45984", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944250", "l": "Association of procollagen type XXV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23304", "l": "atropine + H2O = H(+) + tropate + tropine", "d": [], "t": []}, {"i": "EC:3.1.1.10", "l": "\"tropinesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19929", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.12", "l": "\"cellulose synthase (UDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015483", "l": "long-chain fatty acid transporting porin activity", "d": ["Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}, {"i": "TCDB:1.B.9.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.384", "l": "\"NDP-glycosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047422", "l": "N-acyl-D-aspartate deacylase activity", "d": ["Catalysis of the reaction: N-acyl-D-aspartate + H2O = D-aspartate + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57457", "l": "(E)-sinapate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48656", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58196", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]", "d": [], "t": []}, {"i": "EC:3.5.1.98", "l": "\"histone deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805399", "l": "TAF1 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034737", "l": "ergosterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199910", "l": "MSK1 activates ATF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39868", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39319", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56036", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45333", "l": "7,8-dihydroneopterin + O2 => 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16609", "l": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": [], "t": []}, {"i": "EC:2.4.2.7", "l": "\"adenine phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139893", "l": "Granzyme-B activates BID by cleavage (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74021", "l": "glycine(in) + L-alanine(out) => glycine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59789", "l": "H2O + NAD(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51608", "l": "(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19319", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47533", "l": "chenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16076", "l": "2,2-dialkylglycine + H(+) + pyruvate <=> CO2 + dialkyl ketone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863727", "l": "STON2 is neddylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163595", "l": "2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11801", "l": "H2O + NAD(+) => AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683774", "l": "p-T68-CHEK2 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54167", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55356", "l": "11-cis-retinol = 13-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60878", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74407", "l": "2 (S)-lactate(in) + thromboxane B2(out) = 2 (S)-lactate(out) + thromboxane B2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18278", "l": "a thiol + S-adenosyl-L-methionine => a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36052", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O => 2 beta-L-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709547", "l": "ESTG binds ESR2:chaperone complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26426", "l": "ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.2", "l": "\"CTP synthase (glutamine hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788867", "l": "FN3K phosphorylates ketosamines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615490", "l": "p-S133-CREB1 binds MIR132 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29633", "l": "alpha-D-glucose + D-maltotriose => D-maltotetraose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15479", "l": "5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5beta-scymnol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.820554254294692", "identifiers": [{"i": "GO:0015645", "l": "fatty acid ligase activity", "d": ["Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018584", "l": "2,4,5-trichlorophenoxyacetic acid oxygenase activity", "d": ["Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46790", "l": "a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47530", "l": "isocholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190261", "l": "FGFR3c binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21685", "l": "(R)-beta-alanopine + H2O + NAD(+) => beta-alanine + H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35119", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005121", "l": "Toll binding", "d": ["Binding to a Toll protein, a transmembrane receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247844", "l": "WNT ligands traffic to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005132", "l": "type I interferon receptor binding", "d": ["Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450325", "l": "c-FOS activation by phospho ERK1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68307", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] <=> 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20731", "l": "H2O + L-glutamate + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39419", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63872", "l": "2-oxoglutarate + L-isoleucine + O2 = 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.74", "l": "\"L-isoleucine 3(1)-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37743", "l": "dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2", "d": [], "t": []}, {"i": "EC:2.5.1.129", "l": "\"flavin prenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69750", "l": "(indol-3-yl)acetate + succinyl-CoA <=> (indol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15024", "l": "(E)-feruloyl-CoA + L-quinate <=> 4-O-feruloyl-D-quinate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445079", "l": "Phosphorylation of L1 by ERK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952128", "l": "RUNX3 binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57590", "l": "(2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49534", "l": "ethylene glycol + H(+) + terephthalate => 4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177942", "l": "EGFR binds EGF ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59102", "l": "H(+) + triglucosyl-enterobactin + UDP => diglucosyl-enterobactin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36396", "l": "7-dehydrocholesterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13949", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] = NADPH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37531", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008692", "l": "IL37(?-218) binds SMAD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875374", "l": "MET binds LRIG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948066", "l": "K63polyUb-IRAK1 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24071", "l": "cyclohexanone + H(+) + NADPH + O2 <=> H2O + hexano-6-lactone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19926", "l": "D-ribitol 5-phosphate + NAD(+) => D-ribulose 5-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070403", "l": "NAD+ binding", "d": ["Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878117", "l": "RUNX3 binds ZFHX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873923", "l": "STARD10 binds LPCAT1 and PC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296233", "l": "T2Rs bind bitter-tasting compounds (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.12", "l": "\"ABC-type L-arabinose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31862", "l": "(S)-2,3-epoxysqualene <=> glutinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-708349", "l": "Activated NOD2 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008684", "l": "2-oxopent-4-enoate hydratase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34054", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O <=> 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25472", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-himachalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39065", "l": "H(+) + NADPH + scyllo-inosose => NADP(+) + scyllo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60127", "l": "pre-sodorifen diphosphate <=> diphosphate + sodorifen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64477", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11806", "l": "an aromatic carboxylate + 2 H(+) + NADH => an aromatic aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58880", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38263", "l": "(2R,3S)-beta-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.148", "l": "\"2-methylfumaryl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661432", "l": "BIL binds ALB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20443", "l": "3-sulfino-L-alanine + H(+) => L-cysteine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676229", "l": "WIPIs bind PI3P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43234", "l": "H(+) + isatinate => H2O + isatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33980", "l": "DIBOA beta-D-glucoside + H2O => D-glucose + DIBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15349", "l": "L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate", "d": [], "t": []}, {"i": "EC:2.3.1.35", "l": "\"glutamate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772430", "l": "CTNNBIP1 binds beta-catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139893", "l": "Granzyme-B activates BID by cleavage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69517", "l": "N-acetyl-D-galactosamine + O2 => H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17867", "l": "6,7-dihydropteridine + H(+) + NADPH => 5,6,7,8-tetrahydropteridine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706315", "l": "Active FLT3 binds to SH2B3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61790", "l": "AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38847", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54802", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015571", "l": "N-acetylgalactosamine transmembrane transporter activity", "d": ["Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013021", "l": "GDIs block activation of RHOB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757688", "l": "SERPINA6 binds PREDN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375131", "l": "Basigin binds CD98 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030159", "l": "signaling receptor complex adaptor activity", "d": ["The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52820", "l": "L-serine + succinyl-CoA = CoA + O-succinyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40504", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592297", "l": "Full activation of MMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350901", "l": "Iodide is organified (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433711", "l": "Cis-homodimerization of nectins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850945", "l": "Casein kinase II phosphorylates PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64152", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36547", "l": "octadecanoyl-CoA + sphinganine = CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33242", "l": "L-threonine + NAD(+) <=> aminoacetone + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56399", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418662", "l": "Src activation following P2Y purinoceptor activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63991", "l": "2-thiocytidine + ATP <=> 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944220", "l": "Association of procollagen type XXIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57868", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.62", "l": "\"trans-4-coumaroyl-CoA 2'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842656", "l": "ALK binds ALKAL ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824472", "l": "TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73820", "l": "choline(in) + 2 H(+)(out) => choline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173771", "l": "Formation of RTC (Reverse Transcription Complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31092", "l": "acetyl-CoA + dodecanoyl-CoA => 3-oxotetradecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12527", "l": "L-pipecolate + NADP(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0017050", "l": "D-erythro-sphingosine kinase activity", "d": ["Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54441", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) => a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75477", "l": "D-mannose(in) + n Na(+)(in) => D-mannose(out) + n Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73538", "l": "CDP(out) + UTP(in) <=> CDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10213", "l": "2-oxoglutarate + 5-aminopentanoate => 5-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34885", "l": "ADP + H(+) + phosphate + selenate(in) => ATP + H2O + selenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879907", "l": "Tyrosine kinases phosphorylate the receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76843", "l": "H2O + NAD(+) + octylamine = H(+) + NADH + NH4(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671691", "l": "PRLR-bound STAT5 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008521", "l": "acetyl-CoA transmembrane transporter activity", "d": ["Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66978", "l": "alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68474", "l": "(E)-alpha-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50097", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19696", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) <=> 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31845", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53526", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14197", "l": "ATP + L-aspartate + NH4(+) = ADP + H(+) + L-asparagine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.4", "l": "\"aspartate--ammonia ligase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805285", "l": "PLK3 phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984994", "l": "RUNX2 binds MAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138432", "l": "DVL2 is phosphorylated by PKC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799761", "l": "TP53 binds PPP1R13L (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043825", "l": "succinylornithine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28944", "l": "glycine betaine(in) => glycine betaine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74349", "l": "O-acyl-(R)-carnitine(out) => O-acyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45587", "l": "3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419644", "l": "Transphosphorylation of pLIMK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183051", "l": "CBL ubiquitinates Sprouty (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76890", "l": "5-hydroxypentan-2-amine + H2O + NAD(+) <=> 5-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58708", "l": "rifampicin ortho-naphthoquinone carboxamide = rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43989", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62040", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14203", "l": "D-xylulose => D-lyxose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018874", "l": "CYP monooxygenates EPA to 18(S)-HpEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74802", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31189", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3S)-hydroxydecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23417", "l": "(2R)-O-phospho-3-sulfolactate + H2O => (2R)-3-sulfolactate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13825", "l": "GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70678", "l": "H2O + Met-enkephalin-Arg-Phe <=> L-arginyl-L-phenylalanine + Met-enkephalin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0018635", "l": "(R)-limonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333671", "l": "CLCAs self cleave (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47807", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17331", "l": "(1R,4R)-camphor + H(+) + NADH => (1R,2S,4R)-borneol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660514", "l": "MTF1 dimer:12Zn2+ binds CSRP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66513", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44055", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014454", "l": "RHOG translocates to the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26042", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose <=> beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18273", "l": "H2O + O2 + putrescine = 4-aminobutanal + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.10", "l": "\"putrescine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55141", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878654", "l": "ACP6 hydrolyses MYS-LPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696275", "l": "RND2 binds GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24414", "l": "4-formylbenzenesulfonate + H(+) + NADH => 4-(hydroxymethyl)benzenesulfonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48795", "l": "GDP-beta-L-fucose + Lc4Cer <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685604", "l": "SLAMF6 binds SLAMF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34457", "l": "9-cis-beta-carotene => all-trans-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50939", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate <=> acetoacetyl-CoA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140618", "l": "ferric-chelate reductase (NADH) activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + NAD+ + H+ -> 2 Fe2+-siderophore + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13518", "l": "ATP + dTMP => ADP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74055", "l": "D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174967", "l": "NAT2 acetylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050157", "l": "ornithine racemase activity", "d": ["Catalysis of the reaction: L-ornithine = D-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75546", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] <=> (2E)-decenoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848776", "l": "PTK6 phosphorylates DOK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35791", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine = H(+) + kanamycin X + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785762", "l": "IL13RA1 binds TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67304", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = H2O2 + myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25861", "l": "GTP + H2O => 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019992", "l": "diacylglycerol binding", "d": ["Binding to a diacylglycerol, a diester of glycerol and two fatty acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71573", "l": "5-aminoethoxy-methyl-dUMP in DNA + CO2 => 5-O-(L-seryl)-dTMP in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64079", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247839", "l": "Retromer associates with WLS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202164", "l": "Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709406", "l": "CO binds to Cytochrome c oxidase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19852", "l": "H2O + NADP(+) <=> ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10156", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.101", "l": "\"dihydrochelirubine 12-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17330", "l": "(1R,2S,4R)-borneol + NAD(+) => (1R,4R)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167089", "l": "Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11462", "l": "AMP + D-glucose 6-phosphate + H(+) => ADP + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70315", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.94", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2248891", "l": "M6PR transports activated ARSA to the lysosome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008507", "l": "sodium:iodide symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391868", "l": "Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004665", "l": "prephenate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-874087", "l": "SGT1 binds HSP90 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183122", "l": "Factor D cleaves C3b-bound Factor B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823706", "l": "VWF variant does not bind GPIb:IX:V (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.30", "l": "\"D-psicose 3-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857348", "l": "Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015419", "l": "ABC-type sulfate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24403", "l": "ATP + UMP <=> ADP + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13517", "l": "ATP + dTMP = ADP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425861", "l": "Activation of Protein Kinase C novel isoforms (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018447", "l": "chloral hydrate dehydrogenase activity", "d": ["Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56664", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47504", "l": "chenodeoxycholate + NADP(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58000", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg3 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983194", "l": "Kinesin-1 is a heterotetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173542", "l": "SMURF2 ubiquitinates SMAD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114558", "l": "Thrombin-activated PARs activate Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72088", "l": "2 Na(+)(out) + taurodeoxycholate(out) => 2 Na(+)(in) + taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13148", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate <=> alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17540", "l": "(R)-carnitinamide + H2O <=> (R)-carnitine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033891", "l": "CC-preferring endodeoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166220", "l": "FA anion diffuses laterally to UCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430096", "l": "GP1b-IX-V binds filamin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30620", "l": "2 A + all-trans-zeta-carotene => 2 AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419334", "l": "Melatonin receptors can bind melatonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21753", "l": "all-trans-violaxanthin => all-trans-capsorubin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693593", "l": "D-loop extension by DNA polymerases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013109", "l": "RHOC GEFs activate RHOC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44325", "l": "1-butyrylglycerol + H2O => butanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008685", "l": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity", "d": ["Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61780", "l": "keto-L-tagatose = keto-L-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83650", "l": "FasL:Fas binds FADD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43343", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10782", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45273", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O => 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043878", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54546", "l": "1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034845", "l": "naphthyl-2-methyl-succinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72384", "l": "Na(+)(out) + urate(in) => Na(+)(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210687", "l": "STAT92E transports from the nucleus to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53191", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48781", "l": "ATP + L-erythrulose => ADP + H(+) + L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953111", "l": "E2F6 binds TFDP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37695", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730842", "l": "PI3K associates with phosphorylated GAB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031896", "l": "V2 vasopressin receptor binding", "d": ["Binding to a V2 vasopressin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034891", "l": "endosulfan diol dehydrogenase activity", "d": ["Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76315", "l": "L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427514", "l": "eNoSC deacetylates histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73007", "l": "D-arabinose 5-phosphate = D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72621", "l": "Ribosomal scanning  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70335", "l": "2-carboxy-L-lyxonolactone + H2O = 2-carboxy-L-lyxonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28891", "l": "H(+)(in) + putrescine(in) = H(+)(out) + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45382", "l": "(4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.5", "l": "\"dextransucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21493", "l": "2,3-dihydroxybenzoate + H(+) => catechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14160", "l": "H2O + triphosphate <=> diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60982", "l": "12-oxododecanoate + H(+) + NADH => 12-hydroxydodecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938356", "l": "RMB14 binds RUNX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51255", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54439", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354060", "l": "Translocation of RIAM to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34696", "l": "(2E,6E)-farnesyl diphosphate => Delta(6)-protoilludene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14851", "l": "L-aspartate + urea => H2O + N-amidino-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72812", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49039", "l": "(-)-pluviatolide + S-adenosyl-L-methionine <=> (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19080", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16613", "l": "acetyl-CoA + an arylamine = an N-acetylarylamine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.5", "l": "\"arylamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0005539", "l": "glycosaminoglycan binding", "d": ["Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757578", "l": "ALB binds PREDN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74850", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP <=> 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76857", "l": "H(+) + NADH + NH4(+) + pentan-2-one => 2-aminopentane + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70689", "l": "4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56798", "l": "adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)alamin-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28105", "l": "GDP-alpha-D-mannose + H2O <=> D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58982", "l": "3,7-dimethylocta-2,6-dienoate + H(+) + H2O2 => citral + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35067", "l": "(S)-carnitine(out) = (S)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791302", "l": "TP53 binds the AIFM2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66057", "l": "indole-3-pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034953", "l": "perillyl-CoA hydratase activity", "d": ["Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32311", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.36", "l": "\"tyrosine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75801", "l": "Na(+)(in) + pyruvate(in) => Na(+)(out) + pyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14527", "l": "AH2 + alpha-cyclopiazonate => A + beta-cyclopiazonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448632", "l": "IL34 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77051", "l": "3,5-dimethylcyclohexanamine + H2O + NADP(+) = 3,5-dimethylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420233", "l": "VIP receptors bind VIP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10164", "l": "(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate", "d": [], "t": []}, {"i": "EC:4.2.1.11", "l": "\"phosphopyruvate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009042", "l": "valine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19861", "l": "a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781840", "l": "ERCC6 binds stalled RNA Pol II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017507", "l": "RHOJ binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029468", "l": "Conversion of PA into DAG by PAP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.88", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73535", "l": "CDP(out) + UTP(in) = CDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694364", "l": "N-glycan glucose trimming of Spike (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64691", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8960973", "l": "RLBP1:11cRAL dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47079", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13928", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018601", "l": "4-nitrophenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: 4-nitrophenol + H+ + NADH + O2 = 4-nitrocatechol + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31234", "l": "4-acetamidobutanal + H2O + NAD(+) <=> 4-acetamidobutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21509", "l": "all-trans-retinyl hexadecanoate + H2O => H(+) + hexadecanoate + retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5220959", "l": "TDG excises 5-formylcytosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14009", "l": "2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.67", "l": "\"chrysanthemyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70956", "l": "H(+)(in) + L-glutamate(in) => H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847534", "l": "RAB43 hydrolyses GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247840", "l": "WLS binds WNT ligands in the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44437", "l": "a 1,2-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610726", "l": "The IFT-A complex recruits TULP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63468", "l": "all-trans-octaprenol + ATP = ADP + all-trans-octaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66498", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47343", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38325", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + glycerol => 2 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75351", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine = 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": [], "t": []}, {"i": "EC:1.4.2.3", "l": "\"pseudooxynicotine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42956", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.204", "l": "\"tRNA (cytosine(38)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977301", "l": "Histidine is decarboxylated to histamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15445", "l": "H(+) + H2O + O-carbamoyl-L-serine = CO2 + 2 NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.3.1.13", "l": "\"carbamoyl-serine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607058", "l": "Activated protein C:PROCR binds F2R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43334", "l": "2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52013", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106251", "l": "N4-acetylcytidine amidohydrolase activity", "d": ["Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate."], "t": []}, {"i": "RHEA:62932", "l": "H2O + N(4)-acetylcytidine = acetate + cytidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24894", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210426", "l": "Glutamate synaptic vesicle docking and priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169895", "l": "Crk's SH3 domain engages C3G (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102134", "l": "(22S)-22-hydroxy-campesterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 = (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63654", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018830", "l": "gamma-hexachlorocyclohexane dehydrochlorinase activity", "d": ["Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51369", "l": "glycine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209177", "l": "ERF binds ETS2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61947", "l": "24-methylenecholesterol + UDP-alpha-D-glucose <=> 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48207", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47025", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62090", "l": "2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH => D-glucosamine 6-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854408", "l": "APOBR dimer binds VLDLs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24480", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": [], "t": []}, {"i": "EC:3.2.1.149", "l": "\"beta-primeverosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38627", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20097", "l": "D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.8", "l": "\"mannonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9846477", "l": "A4GALT transfers galactose to LacCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451310", "l": "Activation of Edited Kainate receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36930", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35406", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) <=> (3R)-vestitone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787820", "l": "IL34 dimer binds CSF1R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46570", "l": "5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77320", "l": "N(omega)-methyl-L-arginine + pyruvate => 5-(3-methylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848370", "l": "IL18 binds IL18R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322431", "l": "XIAP binds TLE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44830", "l": "CoA + O-decanoyl-(R)-carnitine => (R)-carnitine + decanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15574", "l": "N-acetylserotonin + S-adenosyl-L-methionine => H(+) + melatonin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25600", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate <=> (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17181", "l": "a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": [], "t": []}, {"i": "EC:1.14.14.3", "l": "\"bacterial luciferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52816", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989755", "l": "Expression of CYP4A11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31680", "l": "O2 + prosolanapyrone II => H2O2 + prosolanapyrone III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.1", "l": "\"chymotrypsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70088", "l": "methanol + o-quinone methide => hydroxyclavatol methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43569", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870465", "l": "RGGT binds the RAB-binding subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75098", "l": "2 chloride(in) + oxalate(out) <=> 2 chloride(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062082", "l": "HLA-E specific inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23468", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": [], "t": []}, {"i": "EC:1.14.12.14", "l": "\"2-aminobenzenesulfonate 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26094", "l": "(4R)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67032", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11321", "l": "UDP-beta-L-arabinopyranose => UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31173", "l": "(2E)-tetradecenoyl-CoA + H2O => (3S)-hydroxytetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003735", "l": "structural constituent of ribosome", "d": ["The action of a molecule that contributes to the structural integrity of the ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140733", "l": "tRNA ligase activator activity", "d": ["Binds to and increases the activity of a tRNA ligase."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140082", "l": "SUMO-ubiquitin ligase activity", "d": ["Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77150", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58393", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16428", "l": "formaldehyde + H2O + NAD(+) <=> formate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24332", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = H2O + monacolin L carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25195", "l": "3-methylcatechol + H(+) + NADH => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20483", "l": "adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate => 3'-phosphoadenylyl sulfate + coelenterazine h", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.19", "l": "\"aspergillopepsin II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654511", "l": "FGFRL1 dimer binds FGFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52531", "l": "2-oxoglutarate + L-asparagine <=> 2-oxosuccinamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685953", "l": "SIRT6 deacetylates RBBP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0010857", "l": "calcium-dependent protein kinase activity", "d": ["Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35262", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44803", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10688", "l": "H2O + streptomycin 6-phosphate = phosphate + streptomycin", "d": [], "t": []}, {"i": "EC:3.1.3.39", "l": "\"streptomycin-6-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16557", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.45", "l": "\"aminocarboxymuconate-semialdehyde decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38519", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062065", "l": "box H/ACA snoRNP complex binding", "d": ["Binding to a box H/ACA snoRNP complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44564", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76214", "l": "GMP(in) <=> GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034558", "l": "technetium (VII) reductase activity", "d": ["Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016690", "l": "diarylpropane peroxidase activity", "d": ["Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429101", "l": "HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31652", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63186", "l": "H(+) + NAD(+) + 2 superoxide => NADH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140788", "l": "L-glutamate uniporter activity", "d": ["Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27487", "l": "(S)-2-ureidoglycine + CO2 + NH4(+) => allantoate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11357", "l": "A + H(+) + NADH => AH2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021951", "l": "OPRK1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65344", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26441", "l": "3-hydroxypropanoate + NADP(+) <=> 3-oxopropanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0072545", "l": "tyrosine binding", "d": ["Binding to 2-amino-3-(4-hydroxyphenyl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42525", "l": "uridine(1911/1915/1917) in 23S rRNA => pseudouridine(1911/1915/1917) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050623", "l": "berberine reductase activity", "d": ["Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39424", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58183", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59332", "l": "1'-hydroxy-gamma-carotene + A = 1'-hydroxytorulene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30978", "l": "15-cis-phytoene + 5 A <=> 5 AH2 + all-trans-3,4-didehydrolycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853429", "l": "PHLDA1 binds AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16032", "l": "3-guanidinopropanoate + H2O <=> beta-alanine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73856", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose => 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003831", "l": "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663511", "l": "BIL binds GSTA1, FABP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52480", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11478", "l": "glycerol + phosphate => glycerol 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74397", "l": "2 (S)-lactate(out) + prostaglandin E1(in) => 2 (S)-lactate(in) + prostaglandin E1(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26549", "l": "beta-alaninamide + H2O <=> beta-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36979", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659820", "l": "RB1 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46527", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161193", "l": "abacavir + AMP => abacavir monophosphate + adenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939335", "l": "RNF181 polyubiquinates BCL10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507869", "l": "Aquaporins passively transport glycerol into cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72103", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) = Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24446", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29173", "l": "a ubiquinone + 2 H(+) + 2 superoxide => a ubiquinol + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972949", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917730", "l": "Cargo Recognition And Sorting (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68219", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61852", "l": "campesterol + UDP-alpha-D-glucose = campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31195", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15364", "l": "a dolichyl phosphate + UDP-alpha-D-xylose <=> a dolichyl D-xylosyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26208", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 4-nitrocatechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44774", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73108", "l": "acacetin + S-adenosyl-L-methionine => apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64411", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) <=> 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54935", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] <=> (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75081", "l": "Formation of AT-AC B Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033520", "l": "TYSND1 cleaves TYSND1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388808", "l": "CD28 homodimer binds B7-2 monomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63359", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76212", "l": "GMP(in) => GMP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59859", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium <=> methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209960", "l": "Diiodinated tyrosine can be deiodinated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874685", "l": "CBL binds MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35474", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.1", "l": "\"DNA ligase (ATP)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814298", "l": "Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19870", "l": "an acyl-CoA + glycine => an N-acylglycine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72258", "l": "dopamine + S-adenosyl-L-methionine <=> 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25623", "l": "tuberculosinyl diphosphate => geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52620", "l": "3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56081", "l": "[Rab1 protein]-L-serine + CDP-choline => [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68869", "l": "ATP + benzoate + H(+) + NADPH => AMP + benzaldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25444", "l": "(2E,6E)-farnesyl diphosphate = (1E,4E)-germacrene B + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.71", "l": "\"(E,E)-germacrene B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27686", "l": "ATP + GDP = ADP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006143", "l": "CD46 binds C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874979", "l": "ACBD3 binds GOLGB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28802", "l": "H2O + L-prolinylglycine <=> glycine + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70554", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74537", "l": "4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine => 2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0031593", "l": "polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.11", "l": "\"guluronate-specific alginate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55108", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25715", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191402", "l": "Reduction of presqualene diphosphate to form squalene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14667", "l": "NH4(+) + xanthine => guanine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55435", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18998", "l": "CTP + H(+) + phosphocholine => CDP-choline + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21959", "l": "UDP-alpha-D-glucose + vitexin <=> H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28726", "l": "(S)-allantoin(in) + H(+)(in) <=> (S)-allantoin(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198731", "l": "ERK1/2 activates ELK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71248", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) => beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103023", "l": "ITPase activity", "d": ["Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58829", "l": "(9S,10R)-epoxy-octadecanoate + H2O => 9R,10R-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54957", "l": "ATP + CoA + OPC-6 => AMP + diphosphate + OPC-6-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17863", "l": "20-hydroxy-3-oxopregn-4-en-21-al => 21-hydroxyprogesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659611", "l": "ANO1 inhibitors bind ANO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12820", "l": "2,3-dihydrobiochanin A + NADP(+) <=> biochanin A + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32508", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O => 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22879", "l": "(R)-mandelamide + H2O <=> (R)-mandelate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51382", "l": "CoA + H(+) + N-(9Z-octadecanoyl)-dopamine => (9Z)-octadecenoyl-CoA + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210285", "l": "Trans-homophilic interaction of PECAM-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59675", "l": "D-maltotriose + O2 <=> D-maltotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668395", "l": "CHMP7 binds CC2D1B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37188", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.-", "l": "\"Carboxy-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63920", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29634", "l": "D-maltotetraose + H2O <=> alpha-D-glucose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36160", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29082", "l": "(R)-lactate + ubiquinone-8 <=> pyruvate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733960", "l": "Bile salts and acids dissociate from ALB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61872", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57243", "l": "glyoxal + GMP <=> N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31419", "l": "(2Z,6E)-farnesyl diphosphate = (-)-beta-curcumene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14307", "l": "AMP + diphosphate + L-prolyl-tRNA(Pro) => ATP + L-proline + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26035", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674093", "l": "PDGFRs bind type I TKI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24912", "l": "2-aminobut-2-enoate + L-cysteine => L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55212", "l": "(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50086", "l": "ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out) => ATP + H2O + taurolithocholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58861", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016630", "l": "protochlorophyllide reductase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19041", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12571", "l": "4-nitrophenol + H(+) + NADH + O2 <=> 4-nitrocatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.44", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52631", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O <=> a fatty acid + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18797", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23334", "l": "(2R)-3-phospho-glyceroyl phosphate + GDP => (2R)-3-phosphoglycerate + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928615", "l": "EFNBs bind SFKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50188", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73119", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870466", "l": "RGGT:CHM binds RABs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20498", "l": "a 2-arylethylamine + acetyl-CoA => an N-acetyl-2-arylethylamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.27", "l": "\"methylmalonate-semialdehyde dehydrogenase (CoA acylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130349", "l": "Generation of CLIP from lip10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12357", "l": "D-mannose 6-phosphate => D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031807", "l": "H1 histamine receptor binding", "d": ["Binding to a H1 histamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64144", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine = (9Z)-octadecenoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77162", "l": "H2O + selenophosphate + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-1-seleno-beta-D-glucosamine + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167478", "l": "Abortive termination of HIV-1 early transcription elongation by DSIF:NELF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30703", "l": "H(+) + salicylate = CO2 + phenol", "d": [], "t": []}, {"i": "EC:4.1.1.91", "l": "\"salicylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19693", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.100", "l": "\"5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56129", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin => AH2 + diphosphate + flavuxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351596", "l": "Dopamine translocates to a secretory vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.-.-", "l": "\"Carbon-carbon lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46249", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015327", "l": "cystine:glutamate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24306", "l": "CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] => glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192624", "l": "cRNA Extension (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70646", "l": "D-proline(out) + H(+)(out) <=> D-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.41", "l": "\"3-hydroxy-D-aspartate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27707", "l": "ATP + D-alanine + D-serine => ADP + D-alanyl-D-serine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42729", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA => 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13747", "l": "microthecin => ascopyrone M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876868", "l": "ECE1 cleaves EDN1(53-90) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40831", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140752", "l": "branched 1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a branched [(1->3)-beta-D-glucosyl](n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909724", "l": "Recruitment of IFNAR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30839", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine", "d": [], "t": []}, {"i": "EC:5.1.3.28", "l": "\"UDP-N-acetyl-L-fucosamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67200", "l": "H2O + N-acetyltyramine = acetate + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68603", "l": "ORC5 binds ORC2:ORC3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693536", "l": "ATM phosphorylates MDC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34619", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.35", "l": "\"1-deoxypentalenic acid 11beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13866", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30145", "l": "CoA + H(+) + octanoate => H2O + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66304", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22428", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N", "d": [], "t": []}, {"i": "EC:1.21.3.1", "l": "\"isopenicillin-N synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032767", "l": "copper-dependent protein binding", "d": ["Binding to a protein or protein complex, in the presence of copper."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74013", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+) => [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77031", "l": "(2R)-heptan-2-amine + H2O + NAD(+) = H(+) + heptan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68735", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63679", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190265", "l": "FGFR4 binds to FGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671747", "l": "Phosphorylated LEPR Binds SHP2 (PTPN11) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682026", "l": "MRN bound to shortened telomeres activates ATM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65011", "l": "ATP + decanoate + H(+) <=> decanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17230", "l": "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031789", "l": "G protein-coupled acetylcholine receptor binding", "d": ["Binding to a G protein-coupled acetylcholine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102046", "l": "3,4-dichlorobenzoate-4,5-oxygenase activity", "d": ["Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor = 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58324", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24165", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2317314", "l": "AKT binds PDPK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.-.-.-", "l": "\"Lyases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210290", "l": "Interaction of PECAM-1 and SHIP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49618", "l": "2-hydroxy-2-methylpropanoate + 2 H(+) + NADH => 2-hydroxy-2-methylpropanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34945", "l": "arbutin 6-phosphate(in) + pyruvate(in) => hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30389", "l": "alpha-D-glucose 1-phosphate + GDP + H(+) => GDP-alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614614", "l": "Cysteine is degraded to serine and H2S (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51351", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine <=> 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52492", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11603", "l": "ATP + CMP <=> ADP + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42073", "l": "(4Z)-2-oxohept-4-enedioate + H2O => (4S)-4-hydroxy-2-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626276", "l": "HSP90 dissociates from LAMP2a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54624", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA = 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10928", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16548", "l": "formyl-CoA + oxalate <=> formate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21757", "l": "deacetylisoipecoside + H2O => dopamine + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17991", "l": "ADP + H(+) + O-phospho-L-seryl-[protein] => ATP + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73794", "l": "dimethylallyl diphosphate + neoechinulin A <=> diphosphate + variecolorin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34179", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate", "d": [], "t": []}, {"i": "EC:3.1.1.93", "l": "\"mycophenolic acid acyl-glucuronide esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17757", "l": "H(+) + L-methionine = 3-(methylsulfanyl)propanamine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.57", "l": "\"methionine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964274", "l": "G alpha (12) binds BTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46156", "l": "15,9'-di-cis-phytofluene + a plastoquinone = 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11999", "l": "biphenyl-2-ol + H(+) + NADH + O2 <=> biphenyl-2,3-diol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44173", "l": "H2O + NAD(+) + tetradecanal => 2 H(+) + NADH + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392295", "l": "Gbeta:gamma recruits PI3K gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36807", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA = 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797961", "l": "CHDH oxidises Cho to BETALD (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654409", "l": "Activated FGFR3 binds FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31717", "l": "11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66809", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH => 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102310", "l": "dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity", "d": ["Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) = dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36285", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => 1,7-dimethylxanthine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19771", "l": "H2O + phaseollidin => phaseollidin hydrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008403", "l": "25-hydroxycholecalciferol-24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450325", "l": "c-FOS activation by phospho ERK1/2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433501", "l": "Interaction of other adapter proteins with p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14217", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756671", "l": "EOMES and TBXT bind the NANOG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52384", "l": "L-glutamate + O-phospho-L-serine = H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.140", "l": "\"N-(2-amino-2-carboxyethyl)-L-glutamate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052719", "l": "apurinic/apyrimidinic endoribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14471", "l": "(2Z,4E)-2-aminomuconate + 2 H(+) + NADH => 2-aminomuconate 6-semialdehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18525", "l": "3-methylbutanol + NADP(+) = 3-methylbutanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050612", "l": "arsenate reductase (donor) activity", "d": ["Catalysis of the reaction: A + arsenite + H2O = AH(2) + arsenate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41420", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 = CO2 + grixazone B + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34602", "l": "15-methylhexadecasphinganine + NADP(+) <=> 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963851", "l": "VD3 dissociates from GC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17572", "l": "(R)-reticuline + NADP(+) <=> 1,2-dehydroreticuline + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254251", "l": "ERBB4s80 binds YAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69958", "l": "Ca(2+)(in) + 3 Na(+)(out) <=> Ca(2+)(out) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67501", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32672", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine => ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10375", "l": "CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43211", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55648", "l": "2-oxoglutarate + O2 + validoxylamine A = CO2 + H(+) + succinate + validoxylamine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849102", "l": "SRMS phosphorylates PTK6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800298", "l": "HGF dimer binds MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58379", "l": "decan-1-ol + NADP(+) <=> decanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49794", "l": "CoA + H(+) + N-eicosanoylglycinate => eicosanoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40746", "l": "(20S)-ginsenoside Rd + 2 H2O <=> (20S)-ginsenoside C-K + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434989", "l": "SEMA7A binds to PLXNC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17973", "l": "diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954082", "l": "E2F6 binds the PRC1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448632", "l": "IL34 dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209094", "l": "Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24674", "l": "ATP + cytidine = ADP + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35927", "l": "paromamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76774", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,3-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050161", "l": "succinyl-CoA:oxalate CoA-transferase", "d": ["Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77644", "l": "adenosine 2',5'-bisphosphate + H2O => AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429767", "l": "Passive I- efflux mediated by SMCT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30011", "l": "ATP + beta-D-galactose(out) + H2O = ADP + beta-D-galactose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71753", "l": "2-oxoglutarate(in) + glutarate(out) => 2-oxoglutarate(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.9.1", "l": "\"pyruvate, phosphate dikinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67701", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296045", "l": "Activation of Potassium transport channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77078", "l": "(1R,4R,5S)-acoradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67928", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O = a 3'-end 3'-phosphouridine-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48742", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72123", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) = Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.775903698273282", "identifiers": [{"i": "GO:0008484", "l": "sulfuric ester hydrolase activity", "d": ["Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2."], "t": []}, {"i": "EC:3.1.6.-", "l": "\"Sulfuric ester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428917", "l": "G13 activation by TP receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047291", "l": "lactosylceramide alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16038", "l": "phosphate + thymidine => 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532549", "l": "MPI isomerises Fru6P to Man6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662599", "l": "MT1M binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444511", "l": "Formation of MSH2:MSH3 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61601", "l": "[DsbD protein]-disulfide + [protein]-dithiol => [DsbB protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809309", "l": "MTMR6 binds MTMR9 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211731", "l": "Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21692", "l": "CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.16", "l": "\"CDP-glycerol diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21387", "l": "L-phenylalanine <=> (E)-cinnamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65266", "l": "AH2 + chrodrimanin C => 3-hydroxypentacecilide A + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23342", "l": "D-arabinose + pyruvate => 3-deoxy-alpha-D-manno-oct-2-ulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63388", "l": "2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a", "d": [], "t": []}, {"i": "EC:1.17.99.9", "l": "\"heme a synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420883", "l": "Opsins act as GEFs for G alpha-t (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681375", "l": "KIT binds ripretinib (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671855", "l": "Phosphorylated LEPR Binds STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66838", "l": "asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950740", "l": "CANX dissociates from IL12A:EBI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38590", "l": "UDP-alpha-D-glucose + vancomycin aglycone <=> devancoaminyl-vancomycin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20911", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48112", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222020", "l": "NUAK1 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41765", "l": "a ganglioside GD3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GT3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43527", "l": "L-allo-threonine + NADP(+) <=> aminoacetone + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099581", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential", "d": ["Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030737", "l": "iodophenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749351", "l": "CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67949", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38486", "l": "a 2,3-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42122", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.39", "l": "\"xyloglucan 6-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48814", "l": "(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53334", "l": "2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74199", "l": "aspulvinone E + O2 = (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693598", "l": "ATM phosphorylates NBN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56372", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676257", "l": "Formation of the SET1A complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10975", "l": "D-hexose + H(+) + phosphoramidate <=> alpha-D-hexose 1-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445448", "l": "HHIP binds Hedgehog (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63649", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.41", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43470", "l": "(8Z,10E,14Z)-12-hydroperoxyeicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047581", "l": "4-methyleneglutamate-ammonia ligase activity", "d": ["Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH4 = 4-methylene-L-glutamine + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19795", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein] => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0031871", "l": "proteinase activated receptor binding", "d": ["Binding to a proteinase activated receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20485", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.65", "l": "\"(S)-cheilanthifoline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000031", "l": "mannosylphosphate transferase activity", "d": ["Catalysis of the transfer of a mannosylphosphate group from one compound to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16025", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA = an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.171", "l": "\"anthocyanin 6''-O-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750942", "l": "USP14 deubiquitinates NLRC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64823", "l": "2-phenylacetamide + H2O <=> 2-phenylacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48074", "l": "a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => a ganglioside GM1 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63517", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 => biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202325", "l": "Recruitment of Gads to LAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63642", "l": "2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27611", "l": "formate + H(+) => CO2 + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10564", "l": "H2O + oxaloacetate 4-methyl ester = H(+) + methanol + oxaloacetate", "d": [], "t": []}, {"i": "EC:3.1.1.44", "l": "\"4-methyloxaloacetate esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140685", "l": "FAD-dependent histone H3K9me/H3K9me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38180", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140997", "l": "histone H4 kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835255", "l": "Expression of TFAP2A in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167481", "l": "Abortive termination of HIV-1 elongation after arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74427", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58378", "l": "decanal + H(+) + NADPH => decan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59107", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate <=> a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.112", "l": "\"site-1 protease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417896", "l": "P2Y6 receptor can bind to UDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40056", "l": "1,2,3-trioctanoylglycerol + H2O => 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17548", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] <=> [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-996727", "l": "REST recruits the BHC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65489", "l": "3 ATP => 2',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14114", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O => a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30945", "l": "(2E)-octenoyl-CoA + FADH2 => FAD + H(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0018671", "l": "4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28172", "l": "butan-2-one + hydrogen cyanide => (2R)-2-hydroxy-2-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186798", "l": "GAP binds to PDGF-beta receptors only (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855648", "l": "SALM3 binds LAR-RPTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20574", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866269", "l": "ARRB bind GPCRs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12317", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31175", "l": "(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749647", "l": "CES2 hydrolyzes ASA- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72516", "l": "(R)-carnitine(out) + glutarate(in) => (R)-carnitine(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34382", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35383", "l": "precorrin-6B + S-adenosyl-L-methionine = CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22546", "l": "a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41129", "l": "1-dodecanoyl-sn-glycerol + H(+) + phosphocholine => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42197", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102400", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454843", "l": "E-cadherin degradation by MMP3, MMP7 and plasmin. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0016812", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9842656", "l": "ALK binds ALKAL ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39780", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56948", "l": "pyruvate + UTP = H(+) + phosphoenolpyruvate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60948", "l": "(S)-eriodictyol + S-adenosyl-L-methionine = (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22051", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71515", "l": "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791128", "l": "Expression of LMNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52614", "l": "3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein] => 3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60913", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005313", "l": "L-glutamate transmembrane transporter activity", "d": ["Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53741", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O => [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62294", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70894", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) <=> L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391935", "l": "DP1 receptor can bind PGD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54750", "l": "AMP + diphosphate + L-firefly luciferyl-CoA => ATP + CoA + firefly L-luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30110", "l": "D-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17053", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": [], "t": []}, {"i": "EC:2.2.1.2", "l": "\"transaldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61590", "l": "ADP + amicoumacin A 2-phosphate + H(+) => amicoumacin A + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23609", "l": "H(+) + H2O + N-isopropylammelide => cyanurate + isopropylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877404", "l": "RUNX1 binds the promoter of the CTLA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14628", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) <=> [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61339", "l": "ATP + H2O + protoporphyrin IX(in) <=> ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000979", "l": "RNA polymerase II core promoter sequence-specific DNA binding", "d": ["Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(in) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050179", "l": "phenylserine aldolase activity", "d": ["Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327886", "l": "SLRPs bind TGF Beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19645", "l": "a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.122", "l": "\"D-threo-aldose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29776", "l": "alpha-D-ribose 1-phosphate + ATP => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50144", "l": "ethyl (9Z)-hexadecenoate + H2O = (9Z)-hexadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654533", "l": "KRAS4B recycles to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74359", "l": "coproporphyrin I(out) = coproporphyrin I(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54892", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41071", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21445", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) => H(+) + NADH + trans-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.58", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730903", "l": "Oligomerization of TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41388", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77013", "l": "1-hydroxy-3-methylbutan-2-one + H(+) + NADH + NH4(+) => (2S)-2-amino-3-methylbutan-1-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047009", "l": "3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400434", "l": "FFAR1 binds fatty acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097269", "l": "all-trans-decaprenyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73719", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160935", "l": "SMURF1 ubiquitinates RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21198", "l": "L-methionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51649", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55613", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O => 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47173", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) => 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39813", "l": "18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46016", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63709", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27863", "l": "3'-GMP + H2O => guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626914", "l": "α2-agonists bind ADRA2A,B,C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209973", "l": "Tyrosine is diiodinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60730", "l": "3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH => citral + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58441", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68045", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692376", "l": "BCL2 binds BCL2 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629679", "l": "PDE3A inhibitors bind PDE3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849908", "l": "SALM4 binds flotillin-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005540", "l": "hyaluronic acid binding", "d": ["Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75785", "l": "ADP(out) => ADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58786", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34582", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D <=> 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72535", "l": "H2O + NADP(+) + vanillin = 2 H(+) + NADPH + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701488", "l": "Active ALK phosphorylates JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41888", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39373", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627104", "l": "XIAP binds CASP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781905", "l": "ZRANB1 binds APC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102442", "l": "syringetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine = 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58133", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44684", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662114", "l": "ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38761", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31113", "l": "3-oxohexanoyl-CoA + CoA => acetyl-CoA + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48425", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211193", "l": "Homodimerization  of DFF40 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103103", "l": "UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate = 8-methylthiooctyldesulfoglucosinolate + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016034", "l": "maleylacetoacetate isomerase activity", "d": ["Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55961", "l": "4-(trimethylamino)butanoate + ATP + CoA => 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46942", "l": "ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate => AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000074", "l": "TCN2 binds RCbl in the circulation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015099", "l": "nickel cation transmembrane transporter activity", "d": ["Enables the transfer of nickel (Ni) cations from one side of a membrane to the other."], "t": []}, {"i": "RHEA:29831", "l": "Ni(2+)(in) = Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51812", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102687", "l": "UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin = H+ + dihydrozeatin-7-N-glucose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828714", "l": "M2 mRNA is translated into protein M2-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65899", "l": "glyoxylate + L-kynurenine <=> glycine + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420243", "l": "GHRH receptor binds GHRH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853801", "l": "PSPN binds RET:GFRA4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28500", "l": "S-(hydroxymethyl)mycothiol => formaldehyde + mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379893", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26234", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38024", "l": "gamma-tocotrienol => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77154", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O <=> 1D-myo-inositol 4,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13152", "l": "A + H(+) + NADPH <=> AH2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46849", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59567", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone <=> H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57904", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59689", "l": "D-maltoheptaose + O2 => D-maltoheptaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66548", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol = 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60998", "l": "4-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-leucine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803998", "l": "Nitrite ion and HNO2 form a conjugated acid-base pair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865605", "l": "BRWD1 binds SMARCA4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18747", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) => 2 juglone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55271", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate <=> (R)-glycerate + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0141122", "l": "nitrogen-oxygen hydrolyase activity", "d": ["Catalysis of the breakage of a nitrogen-oxygen bond by means other than hydrolysis and oxidation."], "t": []}, {"i": "EC:4.8.1.-", "l": "\"Hydro-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43474", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21728", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.132", "l": "\"GDP-mannose 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32438", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42459", "l": "4alpha-methylzymosterol <=> zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9834807", "l": "ILF3 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13766", "l": "bromochloromethane + H2O => bromide + chloride + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102954", "l": "dalcochinase activity", "d": ["Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O = dalcochinin + D-glucopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655845", "l": "Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69244", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61423", "l": "(S)-8-oxocitronellyl enol <=> cis-cis-nepetalactol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69005", "l": "Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419003", "l": "Interaction of Nectins with Afadin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66880", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35312", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) => 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685906", "l": "Polyadenylation of SARS-CoV-1 subgenomic mRNAs (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018473", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53787", "l": "beta-muricholate + deoxycholoyl-CoA <=> beta-muricholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674022", "l": "BRAP autoubiquitinates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48643", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) <=> 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070636", "l": "nicotinic acid riboside hydrolase activity", "d": ["Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48652", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51029", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450187", "l": "TAK1 is activated within the TAK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71335", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) = chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16725", "l": "a phosphatidylglycerol phosphate + H2O = a phosphatidylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389961", "l": "ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69038", "l": "3beta-hydroxy-5beta-androstane-17-one + NADP(+) => 5beta-androstane-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25849", "l": "(1S,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606839", "l": "ARSC hydrolyzes steroid sulfates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75661", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24522", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH => H2O + L-saccharopine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57715", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20199", "l": "[heparan-N-sulfate](n) => [heparosan-N-sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44381", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine => a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607058", "l": "Activated protein C:PROCR binds F2R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483089", "l": "PE is converted to PS by PTDSS2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106362", "l": "protein-arginine N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H+ + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP."], "t": []}, {"i": "RHEA:66632", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22345", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA => (R)-rosmarinate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651456", "l": "SERPING1 variant does not bind factor XIIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66124", "l": "2-oxobutanoate + L-histidine = (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11815", "l": "H2O + methanethiol + O2 <=> formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61970", "l": "a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56949", "l": "pyruvate + UTP => H(+) + phosphoenolpyruvate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043915", "l": "L-seryl-tRNA(Sec) kinase activity", "d": ["Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006050", "l": "MECP2:SIN3A complex binds the promoter of the BDNF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44328", "l": "1-octanoylglycerol + H2O = glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24903", "l": "3',3'-c-di-GMP + H2O => 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39404", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10876", "l": "4-hydroxybenzoate + H(+) = CO2 + phenol", "d": [], "t": []}, {"i": "EC:4.1.1.61", "l": "\"4-hydroxybenzoate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57549", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357445", "l": "PAK1-3 dimer disassociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444171", "l": "Receptor FFAR2 binds carboxylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851933", "l": "MET phosphorylates GAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661980", "l": "F8 variant is not secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616367", "l": "NAB2 binds EGR1 to repress CDK5R1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76378", "l": "3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) <=> 3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59625", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine => 4-aminobutanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31902", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45839", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46740", "l": "7-dehydrodesmosterol + H(+) + NADPH = desmosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47069", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1236970", "l": "Proteasomal clevage of exogenous antigen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0016623", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.2.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10370", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850797", "l": "SPINK6 binds KLK13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32645", "l": "17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + H2O + lupanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52610", "l": "2-oxobutanoate + H(+) + NADPH => 2-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53668", "l": "(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.165", "l": "\"(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32510", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O <=> 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43976", "l": "H(+) + hexadecanoate + NADPH + O2 = 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57321", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] => CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0048408", "l": "epidermal growth factor binding", "d": ["Binding to epidermal growth factor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42403", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + lactose 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11756", "l": "ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:6.3.4.15", "l": "\"biotin--[biotin carboxyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875183", "l": "CBL monoubiquitinates activated MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663271", "l": "NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026001", "l": "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56922", "l": "a medium-chain fatty acyl-AMP + diphosphate => a medium chain fatty acid + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37777", "l": "1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70136", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64521", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA => A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796055", "l": "NFE2L2 dependent BCL2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37914", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75159", "l": "NAD(+) + TTP = H(+) + NADP(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73933", "l": "FAD + griseophenone B + H(+) + 2 H2O => chloride + FADH2 + griseophenone C + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577244", "l": "MSH2 variant:MSH6-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033800", "l": "isoflavone 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.11", "l": "\"Xaa-Pro dipeptidyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36847", "l": "FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.180", "l": "\"FAD:protein FMN transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59312", "l": "D-galactose + O2 = D-galactono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173740", "l": "Factor B binds to C3(H2O) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102948", "l": "luteolin C-glucosyltransferase activity", "d": ["Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030184", "l": "nitric oxide transmembrane transporter activity", "d": ["Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72413", "l": "alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O => inulobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10709", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71621", "l": "(S)-malate(out) + 2 thiosulfate(in) => (S)-malate(in) + 2 thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.9", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23036", "l": "2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50580", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102561", "l": "D-ribose 2,5-bisphosphate 2-phosphohydrolase activity", "d": ["Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate = hydrogenphosphate + D-ribofuranose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70430", "l": "H2O + phenylacetyl-CoA <=> 2-phenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13309", "l": "H2O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate", "d": [], "t": []}, {"i": "EC:1.2.1.67", "l": "\"vanillin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18548", "l": "2-dehydro-3-deoxy-L-arabinonate <=> glycolaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11148", "l": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.16.3.1", "l": "\"ferroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75526", "l": "acetyl-CoA + S-methyl-L-cysteine <=> CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28878", "l": "H(+)(in) + L-tyrosine(in) <=> H(+)(out) + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15664", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside <=> an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76106", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine <=> (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37549", "l": "3-dehydro-D-glucose 6-phosphate + H(+) + NADH => D-glucose 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44849", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49374", "l": "H2O + NAD(+) + protoviolaceinate => H(+) + NADH + O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58224", "l": "L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805730", "l": "SETD9 methylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182594", "l": "Association of INK4 family proteins with CDK4/6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77521", "l": "(2R)-2-(furan-2-yl)-2-hydroxyacetonitrile => furfural + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111879", "l": "PIP2 hydrolysis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37872", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 => 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46807", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine <=> a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852200", "l": "Inactivation of LCK by PTPN22 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674018", "l": "BRAP binds RAS:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50041", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62217", "l": "isoepoxydon + NADP(+) => H(+) + NADPH + phyllostine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46921", "l": "(E)-cinnamate + H(+) => CO2 + styrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56684", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": [], "t": []}, {"i": "EC:1.14.19.61", "l": "\"dihydrorhizobitoxine desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985812", "l": "NCK2 binds to ROBO1,(ROBO2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71571", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) = 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36089", "l": "1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56465", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748996", "l": "GST dimers cleave AZA to 6MP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114683", "l": "Phosphorylation of Platelet Sec-1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22264", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 = 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50154", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45879", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858252", "l": "HDLBP binds HDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209840", "l": "Two DITs combine to form thyroxine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604308", "l": "NICD4 traffics to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36533", "l": "(15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA => (13Z)-docosenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20566", "l": "(2E)-geranyl diphosphate + H2O => (1S,2S,4R)-endo-fenchol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047536", "l": "2-aminoadipate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63008", "l": "(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22852", "l": "L-serine + pyruvate = 3-hydroxypyruvate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.51", "l": "\"serine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34072", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102377", "l": "steviol 13-O glucosyltransferase activity", "d": ["Catalysis of the reaction: steviol + UDP-alpha-D-glucose = steviolmonoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110311", "l": "POLZ extends translesion synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12371", "l": "2-dehydro-D-gluconate + A <=> 2,5-didehydro-D-gluconate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74977", "l": "a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+) => a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74832", "l": "UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) => UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0051002", "l": "ligase activity, forming nitrogen-metal bonds", "d": ["Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.6.-.-", "l": "\"Forming nitrogen-metal bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12614", "l": "2 glutathione + L-cystine => glutathione disulfide + 2 L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13656", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose <=> [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46109", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 => (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62820", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445367", "l": "CaMKII binds activated NMDA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21524", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.13", "l": "\"2-isopropylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54832", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.48", "l": "\"jasmonoyl-L-amino acid 12-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50165", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019767", "l": "IgE receptor activity", "d": ["Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55062", "l": "a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694576", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213207", "l": "Formation of collagen networks (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43420", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24214", "l": "4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) => 5-(2-hydroxyethyl)-4-methylthiazole + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49748", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NADP(+) + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43463", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66282", "l": "H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP => solanidine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990725", "l": "cord factor receptor activity", "d": ["Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11983", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) <=> bis-gamma-glutamylcystine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399931", "l": "Activation of Fyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35382", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10993", "l": "glycolate + NADP(+) => glyoxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51722", "l": "AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65231", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14344", "l": "2-oxoglutarate + glyoxylate + H(+) <=> 2-hydroxy-3-oxoadipate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008758", "l": "UDP-2,3-diacylglucosamine hydrolase activity", "d": ["Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35877", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004961", "l": "thromboxane A2 receptor activity", "d": ["Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162092", "l": "carbovir monophosphate + ATP => carbovir diphosphate + ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19244", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980044", "l": "NOTCH1 binds JAG2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17413", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.14", "l": "\"ABC-type aliphatic sulfonate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74541", "l": "creatinine(out) => creatinine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082356", "l": "HSF1-mediated gene expression (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12779", "l": "2-amino-4,7-dihydroxypteridine + chemical entity => 2-amino-4-hydroxypteridine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67747", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O <=> 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39125", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28644", "l": "(2E,6E)-farnesyl diphosphate => alpha-zingiberene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047968", "l": "glyoxylate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + glyoxylate + NADP+ = H+ + NADPH + oxalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34176", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA => 4-hydroxycoumarin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32950", "l": "a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41973", "l": "a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033790", "l": "hydroxymethylfurfural reductase activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40520", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31927", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.109", "l": "\"3-hydroxyindolin-2-one monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928614", "l": "EFNB:GRB4 binds GIT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74434", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69627", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68660", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28264", "l": "3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP => 3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15985", "l": "formate + NAD(+) = CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.17.1.9", "l": "\"formate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299338", "l": "Activation of TRESK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015530", "l": "shikimate transmembrane transporter activity", "d": ["Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605717", "l": "GM2A binds and mobilizes ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917839", "l": "apo-Transferrin dissociates from the receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77716", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42139", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16928", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine <=> (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32391", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912496", "l": "Formation of meiotic holliday junction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56420", "l": "apo-[D-alanyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50045", "l": "an acyl-CoA + H2O => adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14219", "l": "[thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43585", "l": "H2O + iminoarginine => 5-guanidino-2-oxopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686430", "l": "MUS81 binds EME1, EME2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58053", "l": "(2-aminoethyl)phosphonate + acetyl-CoA => (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61098", "l": "(S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33670", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57968", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.170", "l": "\"8-epi-inunolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55981", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O => an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25303", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653957", "l": "Rag dimer formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35360", "l": "3-hydroxyisoheptadecanoyl-CoA => (2E)-15-methylhexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71924", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) => 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24626", "l": "AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr) => ATP + L-threonine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943279", "l": "GGT dimers hydrolyse GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734730", "l": "ORC1 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879674", "l": "CD97 binds CD55 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38894", "l": "H2O + N-hexadecanoylsphing-4-enine <=> hexadecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696605", "l": "USP12, USP26 deubiquitinate AR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028273", "l": "PGH3 spontaneously dehydrates to PGJ3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35578", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32457", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone => (-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74411", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080004", "l": "thalian-diol desaturase activity", "d": ["Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380239", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47271", "l": "bacterioruberin <=> H2O + monoanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804527", "l": "INTL1 binds bacterial glycans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59115", "l": "ATP + L-serine <=> ADP + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69891", "l": "Na(+)(out) + thymidine(out) = Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33664", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53004", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29342", "l": "(S)-malate(in) + 2 H(+)(in) <=> (S)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334160", "l": "UHRF1:Chromatin binds DNMT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39988", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol => all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32959", "l": "H2O + L-isoleucine + NAD(+) = (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25487", "l": "(2E)-geranyl diphosphate <=> (1S,4R)-camphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39995", "l": "an N-acylethanolamine + H2O = a fatty acid + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33618", "l": "ATP + CoA + octadecanoate <=> AMP + diphosphate + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033872", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448629", "l": "IL33 binds IL1RL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801776", "l": "REG3A binds bacterial phospholipids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67367", "l": "H2O + L-threonyl-L-serine <=> L-serine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46853", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043996", "l": "histone H4K8 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164513", "l": "3' PPT-primed initiation of plus-strand DNA synthesis  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0000009", "l": "alpha-1,6-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage."], "t": []}, {"i": "REACT:R-HSA-449718", "l": "Addition of a third mannose to the N-glycan precursor by ALG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26341", "l": "L-selenocysteine + S-methyl-L-methionine = H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.280", "l": "\"selenocysteine Se-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52163", "l": "(E)-phenylacetaldehyde oxime <=> (Z)-phenylacetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74611", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) = UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202466", "l": "Interaction of Bcl10 to CARMA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189406", "l": "4 PBGs bind to form HMB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188345", "l": "The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237129", "l": "Acireductone is created (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354077", "l": "Integrin alphaIIb beta3 activation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53620", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-spiroviolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.158", "l": "\"(-)-spiroviolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38834", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34640", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + neopentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754129", "l": "CDK6 inhibitors bind CDK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48642", "l": "11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655483", "l": "USP1 autocleavage (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57722", "l": "ADP + 5 H(+)(out) + phosphate => ATP + 4 H(+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30156", "l": "FADH2 + 2 Fe(3+) => FAD + 2 Fe(2+) + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50665", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679816", "l": "SIGMAR1 binds dextromethorphan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10948", "l": "ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047565", "l": "3-hydroxypropionate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684234", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73753", "l": "(R)-adrenaline(out) + 2 H(+)(in) => (R)-adrenaline(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25428", "l": "ATP + N-acetyl-D-hexosamine = ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39054", "l": "ATP + cholesterol(in) + H2O <=> ADP + cholesterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.917179239854292", "identifiers": [{"i": "GO:0061659", "l": "ubiquitin-like protein ligase activity", "d": ["Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.34", "l": "\"cathepsin E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975111", "l": "TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45971", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 <=> 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48564", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12402", "l": "NH4(+) + nicotinate beta-D-ribonucleotide => beta-nicotinamide D-ribonucleotide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034658", "l": "isopropylmalate transmembrane transporter activity", "d": ["Enables the transfer of isopropylmalate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2059926", "l": "NPHP4 protein binds LATS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050075", "l": "maleate hydratase activity", "d": ["Catalysis of the reaction: (R)-malate = H2O + maleate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160133", "l": "bicarbonate channel activity", "d": ["Enables the facilitated diffusion of a bicarbonate (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51285", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11573", "l": "FAD + H(+) + H2O + lithocholate => chenodeoxycholate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52422", "l": "phosphate + S-sulfo-L-cysteine => O-phospho-L-serine + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55433", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39891", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + H(+) + vancomycin", "d": [], "t": []}, {"i": "EC:2.4.1.322", "l": "\"devancosaminyl-vancomycin vancosaminetransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201629", "l": "Caspase-mediated cleavage of Tau (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832577", "l": "NS1:NS2 (1C:1B) localizes to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22790", "l": "(methylsulfanyl)acetate + H(+) + L-methionine => dimethylsulfonioacetate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28827", "l": "L-ornithine(out) + putrescine(in) = L-ornithine(in) + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26377", "l": "GTP = cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49437", "l": "cholate + deoxycholoyl-CoA => choloyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19058", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione => a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10056", "l": "(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.14", "l": "\"3-aminobutyryl-CoA ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917696", "l": "Cargo Sequestration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203979", "l": "Coat Assembly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47618", "l": "ethionamide S-oxide + H2O + NADP(+) => ethionamide + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42936", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033862", "l": "UMP kinase activity", "d": ["Catalysis of the reaction: ATP + UMP = ADP + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102686", "l": "UDP-glucose:trans-zeatin 9-N-glucosyltransferase", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin = H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098639", "l": "collagen binding involved in cell-matrix adhesion", "d": ["Any collagen binding that occurs as part of cell-matrix adhesion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24377", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44693", "l": "a fatty acyl-CoA + hexadecasphinganine => CoA + H(+) + N-acylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74381", "l": "2 (S)-lactate(out) + prostaglandin H2(in) => 2 (S)-lactate(in) + prostaglandin H2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44688", "l": "a 2-acylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604451", "l": "NOTCH4 binds FLT4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093342", "l": "SDC2 multimerises (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34260", "l": "(+)-larreatricin + AH2 + O2 => (+)-3'-hydroxylarreatricin + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39324", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54672", "l": "(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate", "d": [], "t": []}, {"i": "EC:3.1.7.12", "l": "\"(+)-kolavelool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140703", "l": "3',3'-cyclic GMP-AMP binding", "d": ["Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688834", "l": "ATXN3 binds VCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68961", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine => 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54923", "l": "13-cis-retinol + NADP(+) <=> 13-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44615", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40591", "l": "decanedioyl-CoA + H2O = CoA + decanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71445", "l": "3-O-methyl-L-dopa(in) + L-phenylalanine(out) => 3-O-methyl-L-dopa(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007561", "l": "E2F1 binds RAD51 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.9", "l": "\"microsomal epoxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358790", "l": "RNF41 ubiquitinates ERBB3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72472", "l": "citrate(out) + D-threo-isocitrate(in) => citrate(in) + D-threo-isocitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34644", "l": "2 S-adenosyl-L-methionine + squalene => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24911", "l": "L,L-cystathionine => 2-aminobut-2-enoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798667", "l": "TDH tetramer oxidises L-Thr to 2A-3OB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72937", "l": "(S)-lactate(in) + 2 Na(+)(in) => (S)-lactate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20840", "l": "H(+) + L-histidine = CO2 + histamine", "d": [], "t": []}, {"i": "EC:4.1.1.22", "l": "\"histidine decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61936", "l": "ATP + cycloheximide(in) + H2O = ADP + cycloheximide(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31302", "l": "H2O + NAD(+) + perillyl aldehyde <=> 2 H(+) + NADH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19435", "l": "6-phospho-D-gluconate + ADP + H(+) => ATP + D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34594", "l": "Co-precorrin-7 + S-adenosyl-L-methionine <=> Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53726", "l": "ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => ATP + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10893", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047769", "l": "arogenate dehydratase activity", "d": ["Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54086", "l": "archaeosine(15) in tRNA + L-glutamate => 7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692880", "l": "HRH3 binds Hist (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76162", "l": "fluoride(in) <=> fluoride(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11101", "l": "4-hydroxyhexan-3-one => 2 propanal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51362", "l": "(9Z)-octadecenoate + L-leucine => H2O + N-(9Z-octadecenoyl)-L-leucine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797090", "l": "CCNK binds CDK12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166792", "l": "Conversion of C2 into C2a and C2b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658104", "l": "SNCAIP binds alpha-synuclein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944254", "l": "Association of procollagen type XXVI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45921", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46204", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31682", "l": "O2 + prosolanapyrone II <=> H2O2 + prosolanapyrone III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17946", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39926", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17721", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.8", "l": "\"long-chain-acyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27757", "l": "H2O + methylglyoxal <=> (R)-lactate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785594", "l": "FANCD2 binds FANCI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70980", "l": "4-aminobutanoate(out) + n H(+)(in) => 4-aminobutanoate(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71928", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) => 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44997", "l": "(R)-carnitine + acetoacetyl-CoA => CoA + O-3-oxobutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14300", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163090", "l": "Elongation Of The Telomeric Chromosome End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.58", "l": "\"lipopolysaccharide glucosyltransferase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73153", "l": "CoA(in) + FMN(out) => CoA(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49369", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52883", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10652", "l": "a long-chain fatty aldehyde + H2O + NAD(+) = a long-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.48", "l": "\"long-chain-aldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001079", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding", "d": ["Binding to beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627107", "l": "XIAP binds CASP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004488", "l": "methylenetetrahydrofolate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45732", "l": "D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}, {"i": "EC:4.1.99.24", "l": "\"L-tyrosine isonitrile synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341294", "l": "Superoxide reduces cytochrome c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34092", "l": "(5R)-5-phosphooxy-L-lysine + H2O => (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22241", "l": "H2O + methylenediurea => N-(carboxyaminomethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70717", "l": "glycine(out) => glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68595", "l": "ORC2 binds ORC3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047515", "l": "1,3-beta-oligoglucan phosphorylase activity", "d": ["Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.203", "l": "\"uronate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035663", "l": "Toll-like receptor 2 binding", "d": ["Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17250", "l": "2 Fe(2+) + 2 H2O + H2O2 => 6 H(+) + 2 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735497", "l": "TBX5 and KAT5 bind the SRF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400204", "l": "PPARA binds RXRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70748", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12201", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => CO2 + mugineate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68139", "l": "acetophenone + H(+) + NADPH <=> (R)-1-phenylethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021412", "l": "PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65352", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49202", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate => D-mannose 6-phosphate + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30247", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 = O2 + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31459", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": [], "t": []}, {"i": "EC:5.3.99.10", "l": "\"thiazole tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34330", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3229181", "l": "CALM1:Ca2+ binds CNG channel (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852010", "l": "BTNL2 binds activated T cells surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45738", "l": "(2E)-hexenoyl-CoA => (3E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77077", "l": "Capping complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796045", "l": "NFE2L2 dependent TXN expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669240", "l": "FLNA binds PAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52418", "l": "CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-D-erythronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30047", "l": "chloroacetaldehyde + H2O + NAD(+) = chloroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39297", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77408", "l": "2,2-dimethylpropanal + hydrogen cyanide => (2S)-2-hydroxy-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65188", "l": "2-oxoglutarate + berkeleyone B + O2 = berkeleydione + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428750", "l": "Gq activation by TP receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65427", "l": "AMP(in) + NAD(+)(out) <=> AMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211193", "l": "Homodimerization  of DFF40 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37767", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901036", "l": "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25265", "l": "2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53956", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) = 4-aminobutanoyl-[BtrI ACP] + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.95", "l": "\"L-glutamyl-[BtrI acyl-carrier protein] decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754974", "l": "ADK phosphorylates RBV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56952", "l": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671839", "l": "Phosphorylated STAT3 Dissociates from Leptin Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102826", "l": "kaempferol-3-glucoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside = kaempferol 3,7-O-diglucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794347", "l": "Homer1,2,3 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36461", "l": "glycine + L-proline => glycyl-L-proline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40465", "l": "(9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8934446", "l": "Activated PKC phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75672", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57763", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008326", "l": "RUNX2 binds HDAC4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247497", "l": "ERBB3 binds neuregulins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052857", "l": "NADPHX epimerase activity", "d": ["Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681980", "l": "ATG12 binds ATG7 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944265", "l": "Association of procollagen type IV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29317", "l": "D-galactose + phosphate => alpha-D-galactose 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202969", "l": "Caspase mediated cleavage of beta-catenin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955844", "l": "RBKS phosphorylates ribose to R5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372529", "l": "Release of acetylcholine at the synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31679", "l": "O2 + prosolanapyrone II = H2O2 + prosolanapyrone III", "d": [], "t": []}, {"i": "EC:1.1.3.42", "l": "\"prosolanapyrone-II oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49167", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23028", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] = acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.1.3.10", "l": "\"malonyl-S-ACP:biotin-protein carboxyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174119", "l": "Free APC/C phosphorylated by Plk1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26339", "l": "H(+) + 2 L-methionine => L-homocysteine + S-methyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46817", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40280", "l": "(R)-carnitine + dodecanoyl-CoA => CoA + O-dodecanoyl-R-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30691", "l": "H2O2 + methanol = formaldehyde + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084505", "l": "Laminins bind HSPG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39977", "l": "2-oxobutanoate + NH4(+) => 2-iminobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63988", "l": "2-thiocytidine + ATP = 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051060", "l": "pullulanase activity", "d": ["Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.10", "l": "\"non-chaperonin molecular chaperone ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018526", "l": "2-aminobenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59734", "l": "AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein] => biotinyl-5'-AMP + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63020", "l": "(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672978", "l": "RAF phosphorylates MAP2K dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205118", "l": "TRAF6 polyubiquitinates NRIF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790944", "l": "NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75146", "l": "prosolanapyrone III <=> solanapyrone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31397", "l": "all-trans-4,4'-diapophytofluene + FADH2 => 15-cis-4,4'-diapophytoene + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674022", "l": "BRAP autoubiquitinates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004173", "l": "ecdysone O-acyltransferase activity", "d": ["Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54613", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 => 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66197", "l": "acetyl-CoA + tryptamine => CoA + H(+) + N-acetyltryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863463", "l": "STON2 binds SYT proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30083", "l": "4 Cu(+) + 4 H(+) + O2 = 4 Cu(2+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.16.3.4", "l": "\"cuproxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22547", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76668", "l": "furfural + H2O + NAD(+) => 2-furoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416683", "l": "SEMA3E binds to PLXND1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22157", "l": "GDP + H2O => GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11954", "l": "2-hydroxy-3-oxopropanoate => 3-hydroxypyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25515", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68785", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + gamma-curcumene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446372", "l": "Association of  PARVA with TESK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31533", "l": "CO2 + N(omega)-hydroxy-L-arginine + succinate => 2-oxoglutarate + L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-901047", "l": "Binding of ERp57 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19070", "l": "(R)-S-lactoylglutathione => glutathione + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61985", "l": "H(+) + NADH + ubiquinone-10 => NAD(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809680", "l": "MTMR12 binds MTM1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814764", "l": "Plasma membrane resorption (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648017", "l": "EML4 binds to microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008784", "l": "alanine racemase activity", "d": ["Catalysis of the reaction: L-alanine = D-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0004033", "l": "aldo-keto reductase (NADP) activity", "d": ["Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25907", "l": "futalosine + H2O <=> dehypoxanthine futalosine + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.150", "l": "\"oligoxyloglucan reducing-end-specific cellobiohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193650", "l": "p75NTR binds to NADE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101013", "l": "mechanosensitive voltage-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39162", "l": "(3R)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693593", "l": "D-loop extension by DNA polymerases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65797", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160138", "l": "23S rRNA pseudouridine(2604) synthase activity", "d": ["Catalysis of the reaction: uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57691", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide <=> cob(II)inamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23986", "l": "7-dehydrocholesterol + H(+) + NADPH => cholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088130", "l": "PLK1 binds FOXM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12968", "l": "ATP + D-galacturonate <=> 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755359", "l": "SARS-CoV-2 8:class I MHC binds BECN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14401", "l": "chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.225", "l": "\"chlordecone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396371", "l": "NOTCH1 Coactivator Complex binds MYC promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54212", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25187", "l": "2-chloroethanol + chloride + H(+) => 1,2-dichloroethane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42598", "l": "prostaglandin G2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654404", "l": "Activated FGFR2 binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210289", "l": "Recruitment of SYK to p-DAP12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39088", "l": "decanedioyl-CoA + O2 => (2E)-decenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75046", "l": "L-cystine(out) + L-leucine(in) <=> L-cystine(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592297", "l": "Full activation of MMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295632", "l": "PPA2A dephosphorylates SPRY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43028", "l": "L-cysteate = 2-aminoprop-2-enoate + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13409", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.7.1.13", "l": "\"preQ1 synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190682", "l": "Connexin synthesis (generic) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48719", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40653", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52058", "l": "12-hydroxyoctadecanoate + H(+) + hexadecanoate => 12-hexadecanoyloxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17769", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.7", "l": "\"choline monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24176", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:2.8.1.4", "l": "\"tRNA uracil 4-sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60282", "l": "H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26343", "l": "H(+) + L-methionine + Se-methyl-L-selenocysteine => L-selenocysteine + S-methyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70971", "l": "citrate <=> isocitrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59143", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12016", "l": "(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.75", "l": "\"(-)-germacrene D synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71835", "l": "estrone 3-sulfate(out) = estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903924", "l": "estradiol binding", "d": ["Binding to estradiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725338", "l": "NPM1-ALK-dependent BCL2A1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473584", "l": "Collagen type III degradation by MMP15 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602473", "l": "Autocatalytic activation of MMP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158849", "l": "Phenol can form a sulfate conjugate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33563", "l": "(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22408", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.1", "l": "\"dimethylallyltranstransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73116", "l": "quercetin + S-adenosyl-L-methionine => H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29009", "l": "H(+)(out) + Mn(2+)(out) => H(+)(in) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204871", "l": "Interaction of Tie2 and Grb2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624033", "l": "Initiation of HCMV DNA Replication (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39821", "l": "2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O => docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69946", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757448", "l": "ST translocates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37129", "l": "CO2 + H(+) + phosphonate + succinate => 2-oxoglutarate + dioxidophosphate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51950", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.41", "l": "\"alditol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30731", "l": "butanoyl-CoA + FAD + H(+) = (2E)-butenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17380", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814153", "l": "ADO oxidises 2AET to HTAU (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35724", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166387", "l": "The FA anion diffuses away laterally from UCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688459", "l": "RIPK3 binds HSP90:CDC37 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18719", "l": "3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine => 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48023", "l": "a globoside Gb3Cer + H2O <=> a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38425", "l": "(9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427570", "l": "Group 3 - Selective Cl- transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69456", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174367", "l": "GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.21", "l": "\"thymidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43771", "l": "an alkylamine + L-glutaminyl-[protein] <=> N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449829", "l": "IL11 binds IL11RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60374", "l": "D-fructose(in) => D-fructose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390930", "l": "5-HT2 receptor can bind serotonin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51104", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38676", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191299", "l": "Squalene is oxidized to its epoxide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24924", "l": "L-homoserine => 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660660", "l": "p300 acetylates RELA subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110485", "l": "DTSC1 AND DTSC2 form a complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38943", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050604", "l": "taxadiene 5-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12107", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35423", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.298", "l": "\"anthocyanidin 3-O-glucoside 5-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11920", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.96", "l": "\"4a-hydroxytetrahydrobiopterin dehydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35749", "l": "7-epizingiberene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0052597", "l": "diamine oxidase activity", "d": ["Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052791", "l": "3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity", "d": ["Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032574", "l": "5'-3' RNA helicase activity", "d": ["Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17124", "l": "carbamoyl phosphate + L-lysine <=> H(+) + L-homocitrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031177", "l": "phosphopantetheine binding", "d": ["Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63877", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 => (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15905", "l": "3-hydroxycyclohexanone + A = AH2 + cyclohexane-1,3-dione", "d": [], "t": []}, {"i": "EC:1.1.99.26", "l": "\"3-hydroxycyclohexanone dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606622", "l": "GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77377", "l": "CO2 + hexadecane => H(+) + heptadecanoate + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10021", "l": "H2O + L-saccharopine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32353", "l": "3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine => 3 S-adenosyl-L-methionine + tricetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45073", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66349", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A => (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3266557", "l": "Factor I cleaves iC3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696266", "l": "RND2 binds effectors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54302", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853762", "l": "RET dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54620", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 = 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806629", "l": "Formation of tonofilament bundles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627350", "l": "SMAC (DIABLO) binds XIAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656893", "l": "OPN1MW binds 11cRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509831", "l": "ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38919", "l": "H2O + sphing-4-enine-phosphocholine = choline + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33681", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58778", "l": "H(+) + NADPH + pyridine-3-carbaldehyde => NADP(+) + pyridine 3-methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10198", "l": "2-succinylbenzoate + H2O => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70252", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70195", "l": "ATP + deamido-NAD(+) = ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170007", "l": "endoplasmic reticulum-lipid droplet tether activity", "d": ["The binding activity of a molecule that brings together a lipid droplet with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41147", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31541", "l": "(2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45291", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 <=> 2-glyceryl-prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218805", "l": "PKC autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22050", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57283", "l": "a guanosine in RNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12210", "l": "4-methylumbelliferone + acetate + H(+) => 4-methylumbelliferyl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77569", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805276", "l": "CDK5 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36204", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045549", "l": "9-cis-epoxycarotenoid dioxygenase activity", "d": ["Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al."], "t": []}, {"i": "EC:1.13.11.51", "l": "\"9-cis-epoxycarotenoid dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692809", "l": "CDC42 binds effectors at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69203", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012835", "l": "GDIs block activation of RHOA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26215", "l": "aphidicolan-16beta-ol + diphosphate => 9alpha-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37833", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72672", "l": "The 60S subunit joins the translation initiation complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112118", "l": "Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58779", "l": "NADP(+) + pyridine 3-methanol <=> H(+) + NADPH + pyridine-3-carbaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102453", "l": "anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019809", "l": "spermidine binding", "d": ["Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75867", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.384", "l": "\"[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydromethanopterin methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33480", "l": "an acyl-CoA + lanosterol => CoA + lanosteryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11044", "l": "a haloacetate + H2O = a halide anion + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64582", "l": "diphosphate + nerylneryl diphosphate => (2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36796", "l": "a ribonucleoside 5'-triphosphate + 2 H2O => a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25923", "l": "A + H2O + quinolin-7-ol <=> 7-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50443", "l": "prostaglandin H1 <=> prostaglandin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25569", "l": "ATP + beta-D-ribosylnicotinate => ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16492", "l": "(R)-prunasin + H2O <=> D-glucose + mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.97", "l": "\"assemblin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354097", "l": "Activation of Talin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14681", "l": "2 2-aminophenol + A + O2 = 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112392", "l": "Resumption of elongation after recovery from pausing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786118", "l": "IL13 binds IL13RA:TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46581", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 => 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654625", "l": "Activated FGFR3 binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696146", "l": "AOC2 deaminates TYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070087", "l": "chromo shadow domain binding", "d": ["Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23971", "l": "(E)-coniferaldehyde + H2O + NAD(+) <=> (E)-ferulate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27884", "l": "3'-CMP + H(+) => 2',3'-cyclophospho-CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62510", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004032", "l": "alditol:NADP+ 1-oxidoreductase activity", "d": ["Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21160", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA", "d": [], "t": []}, {"i": "EC:2.3.3.8", "l": "\"ATP citrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70489", "l": "a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644900", "l": "BDNF gene expression is stimulated by NPAS4:ARNT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190141", "l": "ALAD binds to Pb2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27736", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43439", "l": "coproporphyrinogen III + 3 O2 <=> coproporphyrin III + 3 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814555", "l": "Integrator complex processes the 3' end of snRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984226", "l": "PLK1 phosphorylates NEK9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71782", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) <=> 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40737", "l": "2 D-glucose + gypenoside LXXV => (20S)-ginsenoside Rb1 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29347", "l": "2 H(+)(in) + orotate(in) = 2 H(+)(out) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64255", "l": "glycine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38544", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172126", "l": "DAP12 interacts with NKG2C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67609", "l": "H2O + N(6)-methyl-ATP => diphosphate + H(+) + N(6)-methyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25733", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tetrahomomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.1", "l": "\"CDP-4-dehydro-6-deoxyglucose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019137", "l": "thioglucosidase activity", "d": ["Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031575", "l": "AP-1 binds ARC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201519", "l": "ALK:PTN dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196857", "l": "PANK2 phosphorylates PanK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53563", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15617", "l": "Fe(3+) + Fe(II)-[cytochrome c] = Fe(2+) + Fe(III)-[cytochrome c]", "d": [], "t": []}, {"i": "EC:1.9.98.1", "l": "\"iron--cytochrome-c reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38305", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11472", "l": "an N-methyl-L-amino acid + H2O + O2 = an L-alpha-amino acid + formaldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.2", "l": "\"N-methyl-L-amino-acid oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41805", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013985", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620103", "l": "ALDH2 transforms GTN to NO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785768", "l": "MRN complex binds DNA double strand breaks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60520", "l": "2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354087", "l": "Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17616", "l": "NAD(+) + scyllo-inositol <=> H(+) + NADH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209815", "l": "Tyrosine is monoiodinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49898", "l": "5,10-dihydrophenazine-1,6-dicarboxylate => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790454", "l": "SUMOylation of XPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51993", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10090", "l": "6(F)-alpha-D-galactosylsucrose + H(+) + UDP => sucrose + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73073", "l": "genkwanin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21891", "l": "(1S,2S)-OPC-8 + NADP(+) <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52101", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357828", "l": "RIPK1 is cleaved by CASP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71412", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) => 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665315", "l": "ERBB2 T733I does not bind tesevatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49419", "l": "ADP + alpha-D-ribose 1-phosphate <=> alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.7", "l": "\"ribonuclease P4\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632804", "l": "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29367", "l": "CMP + H2O = cytidine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.32", "l": "\"beta-lytic metalloendopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74741", "l": "7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine => 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989766", "l": "Expression of CTGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947535", "l": "Cyclisation of GTP to precursor Z (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10536", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.10", "l": "\"chondro-6-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75754", "l": "(9Z)-octadecenoate + H2O <=> 10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862771", "l": "PLA2G2A binds bacterial phospholipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14855", "l": "4-hydroxybenzoyl-CoA + chloride + H(+) => 4-chlorobenzoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672951", "l": "Inactive RAFs bind YWHAB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14052", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29690", "l": "alpha-maltoheptaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26264", "l": "H2O + isopimara-7,15-dienal + NADP(+) <=> 2 H(+) + isopimarate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12903", "l": "D-ornithine + urea => D-arginine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.275", "l": "\"gibberellin A9 O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67869", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52635", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76093", "l": "(11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693536", "l": "ATM phosphorylates MDC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111930", "l": "Adenylate cyclase produces cAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679775", "l": "COMT binds COMT Inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028730", "l": "Activated NTRK2 binds FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658438", "l": "SPRED dimer binds NF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61286", "l": "(2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+) => H2O + L-cystine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362416", "l": "Frataxin binds iron (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48117", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168809", "l": "SOCS binding to GHR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753634", "l": "GGT dimers hydrolyse APAP-SG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18654", "l": "barbiturate + H2O => 3-oxo-3-ureidopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40024", "l": "9alpha-copalyl diphosphate + H2O => diphosphate + syn-copalol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72796", "l": "bilirubin-bisglucuronoside(out) => bilirubin-bisglucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869683", "l": "oxPL binds LBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27342", "l": "AH2 + NH4(+) + O2 => A + H(+) + H2O + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28327", "l": "H2O + wogonin 7-O-beta-D-glucuronate => D-glucuronate + H(+) + wogonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167484", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60420", "l": "H2O + triglucosyl-enterobactin = [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635892", "l": "ATF4 binds the ATF3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102630", "l": "gossypetin 8-methyl ester 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine = gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047852", "l": "diferric-transferrin reductase activity", "d": ["Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20161", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = myo-inositol + raffinose", "d": [], "t": []}, {"i": "EC:2.4.1.82", "l": "\"galactinol--sucrose galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73877", "l": "(R)-adrenaline(in) => (R)-adrenaline(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33817", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835411", "l": "FA core complex:HSP70s binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55859", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55217", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + rhizathalene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62378", "l": "(S)-lactate + H(+) + pyruvate => 2,4-didehydro-3-deoxy-L-rhamnonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73602", "l": "CDP(in) + CTP(out) <=> CDP(out) + CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449058", "l": "Interleukin-1 family are secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62833", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29811", "l": "ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)", "d": [], "t": []}, {"i": "EC:7.6.2.15", "l": "\"ABC-type thiamine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050110", "l": "mucinaminylserine mucinaminidase activity", "d": ["Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44676", "l": "a triacyl-sn-glycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44921", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH => (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707690", "l": "BACH1 binds MAFK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44513", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12852", "l": "H2O + O-phospho-L-seryl-[myosin light chain] <=> L-seryl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0001875", "l": "lipopolysaccharide immune receptor activity", "d": ["Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34950", "l": "(Z)-3-aminoacrylate + H(+) + H2O <=> 3-oxopropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66555", "l": "L-glutaminyl-[protein] + serotonin <=> 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11653", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12442", "l": "2-oxoglutarate + H(+) + L-lysine + NADH => H2O + L-saccharopine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46072", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH = hexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140751", "l": "histone octamer slider activity", "d": ["A chromatin remodeler activity that slides core histone octamers along chromosomal DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848873", "l": "PTK6 phosphorylates ARAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54027", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75088", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963851", "l": "VD3 dissociates from GC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17442", "l": "2-oxoglutarate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200646", "l": "Cytosolic folate export across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54955", "l": "ATP + CoA + nonanoate <=> AMP + diphosphate + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047890", "l": "flavanone 4-reductase activity", "d": ["Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61994", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52229", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209536", "l": "IkB is ubiquitinated and degraded (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61969", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444572", "l": "Zinc is an agonist of GPR39 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57014", "l": "a menaquinol + sulfate => a menaquinone + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64712", "l": "1-propanol + NADP(+) = H(+) + NADPH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43491", "l": "7(1)-hydroxychlorophyll a + NAD(+) <=> chlorophyll b + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51430", "l": "2-N-acetamidomethylphosphonate + CoA => acetyl-CoA + aminomethylphosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805285", "l": "PLK3 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416358", "l": "G alpha (q) inhibits PI3K alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68002", "l": "A + chloride + chloroethene + H(+) => 1,1-dichloroethene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30500", "l": "H(+) + N,N-dihydroxy-L-valine => (E)-2-methylpropanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18967", "l": "H2O + uroporphyrinogen III => hydroxymethylbilane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40749", "l": "(3S)-3-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33766", "l": "a (2E)-enoyl-CoA + H(+) + NADPH <=> a 2,3-saturated acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61279", "l": "H2O + L-ornithine + O2 <=> 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30542", "l": "(R)-carnitinyl-CoA <=> (S)-carnitinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11852", "l": "phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109701", "l": "PDPK1 binds PIP3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64014", "l": "A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465924", "l": "OPN1LW binds 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139914", "l": "Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0008186", "l": "ATP-dependent activity, acting on RNA", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132284", "l": "Formation of C5b:C6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036426", "l": "ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031788", "l": "motilin receptor binding", "d": ["Binding to a motilin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954182", "l": "ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35661", "l": "GDP + H(+) + mannosylinositol phosphorylphytoceramide => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30431", "l": "(S)-2,3-epoxysqualene = taraxerol", "d": [], "t": []}, {"i": "EC:5.4.99.35", "l": "\"taraxerol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32581", "l": "(1R,5R)-beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18778", "l": "an alkylmercury + H(+) => an alkane + Hg(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202604", "l": "Formation of a heteromeric BMP receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72906", "l": "butyrolactone II + dimethylallyl diphosphate <=> butyrolactone I + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018754", "l": "GDIs bind RHOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213208", "l": "Type X collagen associates with collagen type II fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53420", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine = H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199587", "l": "KIR2DS1 interacting with HLA-C group 2 (Cw4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53157", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670418", "l": "Phosphorylation of JAK2 downstream of KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031894", "l": "DPAn-3 maresins translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63396", "l": "A + Fe(II)-heme i + H2O = AH2 + Fe(II)-hydroxyheme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43008", "l": "D-serine = 2-aminoprop-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052768", "l": "mannosyl-oligosaccharide 1,3-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805126", "l": "AURKB phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68934", "l": "AMP + diphosphate + NADP(+) + octanal => ATP + H(+) + NADPH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32502", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 <=> (1S,3R,5S)-sabinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624133", "l": "ARL3:GTP binds the UNC119B complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18029", "l": "2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.16", "l": "\"carbamoyl-phosphate synthase (ammonia)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19223", "l": "formate + H(+) + methanol => 2 formaldehyde + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10262", "l": "ADP + H(+) + Mg(2+)(in) + phosphate => ATP + H2O + Mg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21284", "l": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0061507", "l": "2',3'-cyclic GMP-AMP binding", "d": ["Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75163", "l": "NAD(+) + UTP = H(+) + NADP(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34110", "l": "glycine + H(+) + hexadecanoyl-CoA <=> 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29091", "l": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}, {"i": "EC:7.1.1.2", "l": "\"NADH:ubiquinone reductase (H(+)-translocating)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8862771", "l": "PLA2G2A binds bacterial phospholipids (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5622134", "l": "CRABP1 binds atRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11403", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin <=> 4'-O-demethylsordarin + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714483", "l": "RAC2 translocates to the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69584", "l": "GMP + inosine = guanosine + IMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748996", "l": "GST dimers cleave AZA to 6MP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228525", "l": "RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29138", "l": "a menaquinol + 2 H(+)(in) + nitrate <=> a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15967", "l": "1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110050", "l": "deaminated glutathione amidase activity", "d": ["Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9833635", "l": "p-PKR dimer localizes to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951951", "l": "RUNX3 binds EP300 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58398", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61785", "l": "L-allulose => keto-L-fructose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53057", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32949", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 2-acylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052878", "l": "linoleate 8R-lipoxygenase activity", "d": ["Catalysis of the reaction: O2 + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190065", "l": "Activated TrkA receptor internalizes to endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36109", "l": "O-methyl gibberellin A4 + S-adenosyl-L-homocysteine => gibberellin A4 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693593", "l": "D-loop extension by DNA polymerases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213244", "l": "Loading of antigenic peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22444", "l": "(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74885", "l": "GUCYs converts GTP to cGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13777", "l": "ATP + D-ribose 5-phosphate + NH4(+) = 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.7", "l": "\"ribose-5-phosphate--ammonia ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645481", "l": "TIFA oligomerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637764", "l": "Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072571", "l": "mono-ADP-D-ribose binding", "d": ["Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314678", "l": "ASA- acetylates PTGS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102390", "l": "mycophenolic acid acyl-glucuronide esterase activity", "d": ["Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O = mycophenolate + H+ + D-glucopyranuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73564", "l": "dGDP(out) + UTP(in) => dGDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33063", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] = NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}, {"i": "EC:1.18.1.5", "l": "\"putidaredoxin--NAD(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44209", "l": "12-methyltridecanoate + ATP + CoA => 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30170", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate <=> D-sedoheptulose 1,7-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102087", "l": "N-benzoyl-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: benzoate + L-glutamate + ATP = H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210282", "l": "Interaction of GPVI and FceRI gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33447", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687465", "l": "MRN complex binds RBBP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682011", "l": "LC3 binds ATG7 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46521", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24231", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> 4-methylcatechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66408", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O = ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55815", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76530", "l": "2'-deoxyguanosine + H(+) + H2O <=> 2'-deoxyxanthosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63857", "l": "O2 + tetradecanoate => (2R)-2-hydroperoxytetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52436", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66676", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide = 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646685", "l": "Aggresome dissociates from dynein and microtubule (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38899", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11589", "l": "A + H2O + isoquinoline => AH2 + isoquinolin-1(2H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23472", "l": "2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": [], "t": []}, {"i": "EC:2.3.1.122", "l": "\"trehalose O-mycolyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74014", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 <=> [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70009", "l": "2-aminobenzoyl-AMP + diphosphate => anthranilate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28063", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24468", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48538", "l": "1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+) => 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65547", "l": "a ganglioside GM1 + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987214", "l": "p-STAT3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36079", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30550", "l": "(3S)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45554", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine => H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56606", "l": "6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25046", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416516", "l": "GRK2 sequesters activated Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52580", "l": "ATP + H2O + Pb(2+)(in) = ADP + H(+) + Pb(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072582", "l": "17-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+."], "t": []}, {"i": "RHEA:69284", "l": "a 17beta-hydroxy steroid + NADP(+) = a 17-oxo steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10068", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}, {"i": "EC:2.4.1.53", "l": "\"poly(ribitol-phosphate) beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20154", "l": "ATP + L-arabinose => ADP + beta-L-arabinose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75430", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76175", "l": "glycyl-L-glutamate(out) + 3 H(+)(out) = glycyl-L-glutamate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64978", "l": "8-oxo-dGMP + 2 H(+) + 2 phosphate => 8-oxo-dGTP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43202", "l": "2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681987", "l": "LC3 is cleaved by ATG4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57616", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O = dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32607", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-hydroxygeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12763", "l": "3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine => precorrin-3B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35732", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA => 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448741", "l": "IL22RA2 binds IL22 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015182", "l": "L-asparagine transmembrane transporter activity", "d": ["Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70993", "l": "H(+)(out) + L-mannopyranose(out) => H(+)(in) + L-mannopyranose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31147", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) = 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18404", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018774", "l": "RHOBTB1 binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45336", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.250", "l": "\"[Wnt protein] O-palmitoleoyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015044", "l": "rubredoxin-NAD+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112703", "l": "PTPN11 is phosphorylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28970", "l": "L-proline(in) + Na(+)(in) <=> L-proline(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17738", "l": "NADP(+) + shikimate => 3-dehydroshikimate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10553", "l": "D-glucose + O2 => 2-dehydro-D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43660", "l": "ATP + hydrogencarbonate + propanoyl-CoA = ADP + H(+) + methylmalonyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28455", "l": "N(6)-(D-fructosyl)-L-lysine(in) => N(6)-(D-fructosyl)-L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109813", "l": "GRB2-1 binds SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389354", "l": "Activation of Vav1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63715", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20519", "l": "UDP-N-acetyl-alpha-D-galactosamine => UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16451", "l": "CoA + H(+) + N(6')-acetylkanamycin B => acetyl-CoA + kanamycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56370", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+) => 3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170846", "l": "TGFBR2 recruits TGFBR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250962", "l": "botG LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177926", "l": "Dephosphorylation of PAG by SHP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76360", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031813", "l": "P2Y2 nucleotide receptor binding", "d": ["Binding to a P2Y2 nucleotide receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69299", "l": "CDT1 binds geminin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49570", "l": "(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione => 2-glutathionyl-2-methylbut-3-en-1-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.26", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51834", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65200", "l": "S-(acetaldehyde)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668415", "l": "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32893", "l": "alpha-pinene oxide + H2O + NAD(+) => (1S,5S)-alpha-pinene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786501", "l": "TRMT11:TRMT112 methylates guanosine-10 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15072", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a <=> chlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332235", "l": "CBL binds TGFBR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24116", "l": "(2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.25", "l": "\"S-linalool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964759", "l": "Alternative endo-mannosidase I route (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112042", "l": "Opioid binds MOR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905059", "l": "P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018798", "l": "RHOV binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976768", "l": "Factor H binds to C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77206", "l": "3'-phosphoadenylyl sulfate + deoxycholate <=> 3alpha-sulfodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33727", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine = a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83677", "l": "C4 deamination of cytidine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63484", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27460", "l": "3-iodo-L-tyrosine + iodide + NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44636", "l": "2,4-dinitroanisole + H2O = 2,4-dinitrophenol + H(+) + methanol", "d": [], "t": []}, {"i": "EC:3.3.2.14", "l": "\"2,4-dinitroanisole O-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28784", "l": "H2O + L-cysteinylglycine => glycine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63750", "l": "UDP + zolarsartan-2-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12642", "l": "(2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016156", "l": "fumarate reductase (NADH) activity", "d": ["Catalysis of the reaction: NAD+ + succinate = fumarate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42804", "l": "5,6,7,8-tetrahydromethanopterin + A = 7,8-dihydromethanopterin + AH2", "d": [], "t": []}, {"i": "EC:1.5.99.15", "l": "\"dihydromethanopterin reductase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16215", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21593", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) => H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50915", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol <=> 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43337", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) => CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004697", "l": "diacylglycerol-dependent serine/threonine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701147", "l": "TRPV1 binds TRPV1 blockers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043740", "l": "GTP cyclohydrolase IIa activity", "d": ["Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H+ + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0034601", "l": "oxoglutarate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086410", "l": "CDK1 phosphorylates BORA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047081", "l": "3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25690", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.67", "l": "\"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9763200", "l": "BRCA2 mutants do not bind SEM1 (DSS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165179", "l": "Formation of TSC1:TSC2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994000", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61664", "l": "(2E,6E,10E)-geranylgeraniol + ATP = (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564169", "l": "Collagen type VIII degradation by MMP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63208", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal = 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.923108426128749", "identifiers": [{"i": "GO:0046914", "l": "transition metal ion binding", "d": ["Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73677", "l": "ADP(in) + dAMP(out) + H(+)(in) => ADP(out) + dAMP(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37026", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75531", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine = A + H2O + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61838", "l": "ergosteryl 3-beta-D-glucoside + H(+) + UDP => ergosterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22195", "l": "(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378975", "l": "Follitropin is a heterodimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802942", "l": "RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20192", "l": "5,6-dihydrouracil + NAD(+) <=> H(+) + NADH + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34779", "l": "a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111264", "l": "Addition of nucleotides between position +11 and +30 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40771", "l": "(20S)-ginsenoside Rg1 + H2O = (20S)-ginsenoside F1 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.86", "l": "\"N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72113", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in) => L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44074", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18264", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine <=> acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34423", "l": "(-)-secoisolariciresinol + NADP(+) = (+)-lariciresinol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.23.1.2", "l": "\"(+)-lariciresinol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44195", "l": "2-methylhexadecanoate + ATP + CoA <=> 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10807", "l": "(S)-allantoin <=> (R)-allantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77592", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol => 1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782311", "l": "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22664", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose = 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": [], "t": []}, {"i": "EC:2.3.1.103", "l": "\"sinapoylglucose--sinapoylglucose O-sinapoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31201", "l": "(2E)-octenoyl-CoA + H2O => (3S)-hydroxyoctanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46909", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610752", "l": "GLI3R translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.184", "l": "\"UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61792", "l": "ATP + L-tryptophan = diphosphate + L-tryptophyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804253", "l": "MDM2 ubiquitinates JMY (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852552", "l": "MST1R autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702997", "l": "linafinib-resistant FLT3 mutants don't bind linifanib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33030", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010648", "l": "ROBO2 binds AKAP5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32302", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH <=> 2 diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626817", "l": "PKC phosphorylates NCF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55384", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53920", "l": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54833", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016640", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule."], "t": []}, {"i": "EC:1.4.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10006", "l": "benzyl thiocyanate => benzyl isothiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26342", "l": "L-selenocysteine + S-methyl-L-methionine => H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32953", "l": "trehalulose => sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67918", "l": "AMP + NH4(+) => adenosine 5'-phosphoramidate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73800", "l": "SAICAR => AICAR + Fumarate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18212", "l": "(2E)-geranyl diphosphate <=> (2S,4R)-bornyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809785", "l": "MTMR2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9716947", "l": "ESR1 binds ESR1 agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62533", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050207", "l": "plasmanylethanolamine desaturase activity", "d": ["Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31769", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => 2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42939", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13807", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5alpha-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50239", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76062", "l": "heliamine + S-adenosyl-L-methionine <=> H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839065", "l": "Phosphorylation of cytosolic FGFR1 fusion dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56201", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36671", "l": "(17Z)-hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0045569", "l": "TRAIL binding", "d": ["Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726621", "l": "PGR binds PGR antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0080084", "l": "5S rDNA binding", "d": ["Binding to a 5S rDNA sequence, encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114352", "l": "Sequestration of tBID by BCL-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12758", "l": "dihydrozeatin + NADP(+) => H(+) + NADPH + zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047414", "l": "2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity", "d": ["Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H+ = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191072", "l": "Synthesis of Cx43 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73755", "l": "2 H(+)(out) + histamine(in) = 2 H(+)(in) + histamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25615", "l": "terpentedienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34663", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59812", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71957", "l": "glutarate(in) + 3 Na(+)(in) => glutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51643", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102247", "l": "malonyl-malonyl acyl carrier protein-condensing enzyme activity", "d": ["Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] = 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018785", "l": "haloacetate dehalogenase activity", "d": ["Catalysis of the reaction: haloacetate + H2O = glycolate + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64805", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine => CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47181", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) => (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.-.-", "l": "\"Transferring selenium-containing groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201457", "l": "BMP2 binds to the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76640", "l": "cytosine(out) => cytosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75539", "l": "(2E)-decenoate + ATP + holo-[ACP] = (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65968", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73074", "l": "apigenin + S-adenosyl-L-methionine <=> genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76492", "l": "(E)-ferulate + H2O => acetate + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34051", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.113", "l": "\"2'''-acetyl-6'''-hydroxyneomycin C deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61174", "l": "H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55278", "l": "9-cis-retinyl tetradecanoate + CoA => 9-cis-retinol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0050174", "l": "phenylalanine decarboxylase activity", "d": ["Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15706", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA => 2 a ubiquinol + phenylglyoxylyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.4", "l": "\"trypsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51366", "l": "CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73507", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine = 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28855", "l": "H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43196", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28966", "l": "H(+)(out) + L-proline(out) <=> H(+)(in) + L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74095", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140806", "l": "SERPINC1 binds SERPINC1 activators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58721", "l": "(S)-nicotine + NADPH + O2 => H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937989", "l": "RUNX1 binds PRC1 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54666", "l": "pre-alpha-onocerin => (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53844", "l": "glycochenodeoxycholate + NAD(+) = 7-oxoglycolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18671", "l": "adenine + D-ribose => adenosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54565", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O => a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803917", "l": "TP53 stimulates RGCC expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.162", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32624", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102933", "l": "GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity", "d": ["Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26165", "l": "AH2 + echinenone + O2 => 4'-hydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63782", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678327", "l": "MIOX oxidises Ins to GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43878", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24926", "l": "L-homoserine <=> 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71065", "l": "L-arginine(out) + L-histidine(in) => L-arginine(in) + L-histidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64651", "l": "(E)-coniferaldehyde + CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005163", "l": "nerve growth factor receptor binding", "d": ["Binding to a nerve growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52284", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016906", "l": "sterol 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19444", "l": "benzene-1,2,4-triol + O2 <=> 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34387", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987007", "l": "p-STAT1 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193997", "l": "CYP11B1 oxidises 11DCORT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16976", "l": "2-hydroxypyridine + AH2 + O2 <=> 2,5-dihydroxypyridine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63530", "l": "[thioredoxin]-disulfide + 2 H2O => [thioredoxin]-dithiol + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20737", "l": "acetyl-CoA + glycine => (2S)-2-amino-3-oxobutanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71877", "l": "2 Na(+)(in) + taurocholate(in) => 2 Na(+)(out) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46079", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH <=> eicosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57538", "l": "a 5'-end NTP-ribonucleotide-RNA + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16264", "l": "L-lysyl-[protein] + succinyl-CoA <=> CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18640", "l": "H2 + NADP(+) <=> H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11224", "l": "ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.4", "l": "\"D-alanine--D-alanine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71164", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) => H(+)(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41182", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016502", "l": "nucleotide receptor activity", "d": ["Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.731030655927583", "identifiers": [{"i": "GO:0016840", "l": "carbon-nitrogen lyase activity", "d": ["Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)."], "t": []}, {"i": "EC:4.3.-.-", "l": "\"Carbon-nitrogen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322434", "l": "XIAP dissociates from ub-TLE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129375", "l": "Elastin cross-linking by lysyl oxidase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46217", "l": "H(+) + NADPH + progesterone => 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734475", "l": "PPARA binds fibrates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061655", "l": "Pup conjugating enzyme activity", "d": ["Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29945", "l": "2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out) => 2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371554", "l": "HSF1 acetylation at Lys80 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33085", "l": "5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine => dehypoxanthine futalosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32471", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] = (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.66", "l": "\"marmesin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51416", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944254", "l": "Association of procollagen type XXVI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667965", "l": "ANKLE2 binds PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192832", "l": "Initiation of cRNA Synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30358", "l": "a quinol + methane + O2 <=> a quinone + H2O + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789218", "l": "Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25636", "l": "laricitrin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52473", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9675026", "l": "Formation of the MLL1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034512", "l": "box C/D RNA binding", "d": ["Binding to a box C/D small nucleolar RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612509", "l": "SGK phosphorylates SRF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55086", "l": "(3R)-3-hydroxypentanoate + CoA + H(+) => (3R)-3-hydroxypentanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035642", "l": "histone H3R17 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to the arginine residue at position 17 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163320", "l": "Association of mTERF with the termination sequence (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73476", "l": "D-arginine(in) + L-ornithine(out) => D-arginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30558", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 <=> GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46376", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.23", "l": "\"acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21613", "l": "D-gluconate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25858", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49304", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.46", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28780", "l": "4-hydroxy-L-threonine => glycine + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19308", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44305", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA => a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149454", "l": "Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56547", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004754", "l": "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58334", "l": "(E)-non-2-enal + H(+) + NADPH => (E)-non-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12038", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADH => (S)-3-(imidazol-5-yl)lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23822", "l": "GDP-4-dehydro-alpha-D-rhamnose + H2O => GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15468", "l": "ATP + sphinganine <=> ADP + H(+) + sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823992", "l": "Expression of GSC in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59667", "l": "D-cellopentaose + O2 <=> D-cellopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2059926", "l": "NPHP4 protein binds LATS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70031", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75374", "l": "guanosine(in) <=> guanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41800", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29623", "l": "alpha-maltopentaose + beta-maltose = alpha-maltohexaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9736953", "l": "FURIN translocates to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047823", "l": "D-glutamyltransferase activity", "d": ["Catalysis of the reaction: D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4+. Can also transfer additional glutamyl residues to a peptide, extending the polypeptide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983150", "l": "Proteasomal cleavage of substrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40312", "l": "hexanoyl-CoA + O2 => (2E)-hexenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75505", "l": "glycocholate(in) + n H(+)(in) => glycocholate(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26291", "l": "2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate => 2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27307", "l": "A + D-proline => 1-pyrroline-2-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41302", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine <=> (9Z)-octadecenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63464", "l": "(2E,6E,10E)-geranylgeraniol + UTP = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49984", "l": "H(+) + jasmonate + NADPH + O2 = (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.228", "l": "\"jasmomic acid 12-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37520", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73223", "l": "(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10957", "l": "(E)-cinnamate + H(+) + NADPH + O2 => H2O + NADP(+) + trans-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28005", "l": "beta-D-fructose 6-phosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65174", "l": "(3Z,5E)-dodecadienoate + CoA + H(+) => (3Z,5E)-dodecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140761", "l": "sequestered tissue factor -> tissue factor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73227", "l": "(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804762", "l": "TP53 forms homotetramers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15867", "l": "4-hydroxytryptamine + A + H2O => AH2 + O2 + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944261", "l": "Association of procollagen type XIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46053", "l": "a 3'-end uridylyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36656", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine => descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67612", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810392", "l": "TMEM55B translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48377", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016207", "l": "4-coumarate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592316", "l": "Initial activation of proMMP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016205", "l": "selenocysteine methyltransferase activity", "d": ["Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66141", "l": "acetyl-CoA + octopamine => CoA + H(+) + N-acetyloctopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.25", "l": "\"(d)CMP kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41639", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16736", "l": "H(+) + orsellinate <=> CO2 + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295622", "l": "SPRY2 binds CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48104", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77151", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 4,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052616", "l": "ent-kaur-16-en-19-ol oxidase activity", "d": ["Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44840", "l": "(R)-carnitine + octadecanoyl-CoA = CoA + O-octadecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015416", "l": "ABC-type phosphonate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74073", "l": "ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51201", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine => H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64720", "l": "H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24706", "l": "(6R)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": [], "t": []}, {"i": "EC:2.1.2.13", "l": "\"UDP-4-amino-4-deoxy-L-arabinose formyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015274", "l": "organellar voltage-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030372", "l": "high molecular weight B cell growth factor receptor binding", "d": ["Binding to a high molecular weight B cell growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11503", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O <=> 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47210", "l": "2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177922", "l": "EGFR dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449818", "l": "IL13 binds IL13RA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52041", "l": "L-cystine => 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12650", "l": "L-rhamnofuranose + NAD(+) => H(+) + L-rhamnono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.8", "l": "\"myosin ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68597", "l": "(2E,6E)-farnesyl diphosphate => beta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426489", "l": "RISC binds inexactly matching target RNAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32342", "l": "(+)-thujan-3-ol + NADP(+) <=> (+)-thujan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038147", "l": "C-X-C motif chemokine 12 receptor activity", "d": ["Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10271", "l": "2-dehydro-3-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685318", "l": "BCDX2 complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14062", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) => glycine + H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67486", "l": "a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73977", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52951", "l": "deoxycholate + UDP-alpha-D-glucuronate <=> deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097260", "l": "eoxin A4 synthase activity", "d": ["Catalysis of the reaction: leukotriene A4 = eoxin A4."], "t": []}, {"i": "REACT:R-HSA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69245", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381087", "l": "Dimerization of PERK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70148", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018502", "l": "2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity", "d": ["Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69302", "l": "benzyl isothiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63607", "l": "[Pyr1]apelin-13 + H2O <=> [Pyr1]apelin-12 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20295", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH => 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701147", "l": "TRPV1 binds TRPV1 blockers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382096", "l": "Formation of NR-NCOR Corepressor Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333671", "l": "CLCAs self cleave (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904855", "l": "proteasome regulatory particle binding", "d": ["Binding to a proteasome regulatory particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160042", "l": "purine nucleotide uniporter activity", "d": ["Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69710", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-galactose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29296", "l": "aldehydo-D-galacturonate(out) + H(+)(out) => aldehydo-D-galacturonate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705584", "l": "HMGCR dimer binds statins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031727", "l": "CCR2 chemokine receptor binding", "d": ["Binding to a CCR2 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220988", "l": "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47215", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69002", "l": "3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine => 3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24896", "l": "isopimpinellin + S-adenosyl-L-homocysteine => 5-hydroxyxanthotoxin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54197", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23344", "l": "a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose", "d": [], "t": []}, {"i": "EC:3.2.2.1", "l": "\"purine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658435", "l": "RAS GAPs bind RAS:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689861", "l": "Recruitment of XPA and release of CAK  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26007", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate => beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77589", "l": "Recognition of AAUAAA sequence by CPSF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34805", "l": "bisdemethoxycurcumin + 2 CO2 + 3 CoA => 2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34511", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.290", "l": "\"N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0010354", "l": "homogentisate prenyltransferase activity", "d": ["Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837392", "l": "Packaging of antigenomic RNA of human respiratory syncytial virus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909732", "l": "Phosphorylation of STAT2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250220", "l": "Homodimerization of ERBB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685230", "l": "CHEK1 phosphorylates RAD51 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451900", "l": "IL2RB binds JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40988", "l": "EDTA + 2 FMNH2 + 2 O2 => ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183052", "l": "CBL binds to GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210289", "l": "Recruitment of SYK to p-DAP12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943080", "l": "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76123", "l": "a dicarboxylate(in) + prostaglandin E2(out) = a dicarboxylate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047014", "l": "glycerol-3-phosphate 1-dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61897", "l": "betaenone C => betaenone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31946", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37798", "l": "2 H(+) + 2 NADPH + O2 <=> 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38593", "l": "chloroorienticin B + dTDP + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562526", "l": "PLK1 phosphorylates OPTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15299", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685604", "l": "SLAMF6 binds SLAMF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46507", "l": "dodecanoyl-AMP + holo-[ACP] <=> AMP + dodecanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17790", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine => (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59836", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432946", "l": "PARVB/Affixin interacts with alpha PIX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70135", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31211", "l": "ATP + H2O + L-selenomethionine = diphosphate + L-adenosylselenomethionine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67396", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37637", "l": "1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65600", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) = 2 H(+) + jolkinol C + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20592", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618004", "l": "FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202489", "l": "Oligomerization of Bcl10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50133", "l": "ethyl hexadecanoate + H2O => ethanol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990411", "l": "hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)", "d": ["Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14029", "l": "A + H2O + selenite = AH2 + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724290", "l": "GNRHR2 binds GNRH1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008980", "l": "propionate kinase activity", "d": ["Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46241", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72183", "l": "creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39415", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45364", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine = (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34909", "l": "molybdate(out) => molybdate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "50.485694346479235", "identifiers": [{"i": "GO:0022890", "l": "inorganic cation transmembrane transporter activity", "d": ["Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35056", "l": "3,6-dichlorocatechol + O2 => (2E,4E)-2,5-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23548", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.171", "l": "\"16S rRNA (guanine(966)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11626", "l": "acetone oxime + pyruvate => 2-(hydroxyimino)propanoate + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63283", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15143", "l": "4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin] => 4-methylphenol + H2O + 4 oxidized [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40664", "l": "L-serine => 2-aminoprop-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17009", "l": "2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.26", "l": "\"o-succinylbenzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25228", "l": "L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705145", "l": "TBK1, IKBKE form homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015615", "l": "D-allose-importing ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39647", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.30", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70556", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67950", "l": "3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632182", "l": "PRMT1 methylates ESRs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952128", "l": "RUNX3 binds TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13222", "l": "(R)-mevalonate + NAD(+) => (R)-mevaldate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72621", "l": "Ribosomal scanning  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59475", "l": "2',3'-cGAMP + H2O <=> Gp(2'-5')Ap(3') + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050085", "l": "mannitol 2-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097110", "l": "scaffold protein binding", "d": ["Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034923", "l": "phenanthrene-4,5-dicarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018604", "l": "4-aminobenzoate 3,4-dioxygenase (deaminating) activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26197", "l": "H2O + melamine = ammeline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53911", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26131", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-7,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15114", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32986", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938217", "l": "RUNX1 binds the SWI/SNF complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40652", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.8", "l": "\"ribonuclease V\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74863", "l": "(R)-salsolinol + S-adenosyl-L-methionine = H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21928", "l": "3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60340", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62650", "l": "(5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900995", "l": "ubiquinone-6 binding", "d": ["Binding to ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928641", "l": "PAK binds RAC and bPIX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507937", "l": "STAT5 dimers translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030775", "l": "glucuronoxylan 4-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37771", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800315", "l": "MST1 binds MST1R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19707", "l": "H(+) + hexadecanoyl-CoA + NADH => CoA + hexadecanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350651", "l": "Caspase-mediated cleavage of MASK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004791", "l": "thioredoxin-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50222", "l": "(R)-demethyl-4-deoxygadusol => (S)-demethyl-4-deoxygadusol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047407", "l": "ADP-ribosyl-[dinitrogen reductase] hydrolase activity", "d": ["Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49816", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine = 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": [], "t": []}, {"i": "EC:1.7.2.7", "l": "\"hydrazine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48501", "l": "H2O + octanoylglycerol => glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008387", "l": "steroid 7-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.175", "l": "\"(R)-3-(aryl)lactoyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71264", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) => chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035439", "l": "halimadienyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38757", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60220", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928615", "l": "EFNBs bind SFKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693198", "l": "RHOD binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0017002", "l": "activin receptor activity", "d": ["Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052808", "l": "reduced coenzyme F420:NADP+ oxidoreductase activity", "d": ["Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0016937", "l": "short-chain fatty acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49259", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] <=> 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17776", "l": "ATP + L-cysteine + tRNA(Cys) <=> AMP + diphosphate + L-cysteinyl-tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641229", "l": "TLE oligomerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791137", "l": "Expression of Talin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60638", "l": "choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate => N-(dodecanoyl)-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51451", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250280", "l": "ROS oxidize thioredoxin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30058", "l": "L-allo-threonine + NADP(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604763", "l": "Autocatalytic activation of MMP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8934742", "l": "RUNX1 binds PRMT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71056", "l": "L-cysteine(out) + L-methionine(in) => L-cysteine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170004", "l": "lipoate transmembrane transporter activity", "d": ["Enables the transfer of lipoate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983142", "l": "Formation of peptide loading complex (PLC) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53686", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58952", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034013", "l": "aliphatic aldoxime dehydratase activity", "d": ["Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30933", "l": "acetate + H(+) + L,L-cystathionine => L-cysteine + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13022", "l": "H(+) + NADH + O2 + vanillate => 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51404", "l": "H2O + L-arginine + O2 = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.25", "l": "\"L-arginine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11094", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49736", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71419", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) = 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45164", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034186", "l": "apolipoprotein A-I binding", "d": ["Binding to apolipoprotein A-I."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61283", "l": "4-aminobutanoate + H2O + O2 <=> H2O2 + NH4(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39149", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62987", "l": "H2O + hexadecanamide <=> hexadecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353444", "l": "Cleavage of thymine by TDG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15876", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38578", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17747", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP => N-acetyl-D-glucosamine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14905", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": [], "t": []}, {"i": "EC:2.4.2.14", "l": "\"amidophosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12883", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+) => ADP-alpha-D-glucose + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1364044", "l": "PRLR:JAK2 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53199", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756724", "l": "p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36946", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938251", "l": "CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183072", "l": "EGFR non-clathrin mediated endocytosis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9822532", "l": "ADAMTS13 cleaves VWF multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52813", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64047", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102324", "l": "2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381087", "l": "Dimerization of PERK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451310", "l": "Activation of Edited Kainate receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75885", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide => NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56939", "l": "17beta-hydroxy-androst-5-en-3-one <=> testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22372", "l": "H2O + O2 + propionate 3-nitronate = 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": [], "t": []}, {"i": "EC:1.7.3.5", "l": "\"3-aci-nitropropanoate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51182", "l": "5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015275", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70487", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38145", "l": "CO2 + 2 H(+) + 2 hydrogen sulfide => carbon disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602473", "l": "Autocatalytic activation of MMP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61054", "l": "(-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849900", "l": "SALMs1-3 bind each other in cis interactions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701147", "l": "TRPV1 binds TRPV1 blockers (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2512800", "l": "SCARB1:ligand is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11813", "l": "H2O + methanethiol + O2 => formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786421", "l": "CHIA hydrolyses chitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186785", "l": "PDGF-AA clevage by Furin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875523", "l": "MET binds TNS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1671687", "l": "PRLR activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687625", "l": "ATP binds MLKL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68089", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163320", "l": "Association of mTERF with the termination sequence (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905761", "l": "SCF ubiquitin ligase complex binding", "d": ["Binding to a SCF ubiquitin ligase complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54593", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.185", "l": "\"L-glycol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57139", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046871", "l": "N-acetylgalactosamine binding", "d": ["Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52435", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687107", "l": "MAPK4,6 translocate to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981355", "l": "RASA1 binds RAS:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.139", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48031", "l": "H2O + triacetin <=> acetate + diacetylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.8", "l": "\"ATP diphosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17689", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.34", "l": "\"glycochenodeoxycholate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73362", "l": "ATP + beta-alanine + dopamine <=> AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733545", "l": "Bile salts and acids bind ALB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70510", "l": "LDH tetramer oxidises LACT to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952128", "l": "RUNX3 binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022453", "l": "MECP2 binds 5hmC-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71215", "l": "2 Na(+)(out) + thiocyanate(out) = 2 Na(+)(in) + thiocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13547", "l": "(3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047864", "l": "dimethylaniline-N-oxide aldolase activity", "d": ["Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13378", "l": "alpha-D-glucose 1-phosphate + ATP => ADP + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71126", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA <=> AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53333", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140803", "l": "NAD+- protein-cysteine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:56612", "l": "L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5227009", "l": "ABCF1 binds EIF2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "44.2542873363479", "identifiers": [{"i": "GO:0022857", "l": "transmembrane transporter activity", "d": ["Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052807", "l": "aflatoxin reductase (coenzyme F420) activity", "d": ["Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36292", "l": "3-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24386", "l": "AMP + diphosphate + H(+) + L-glutamate + NAD(+) => ATP + deamido-NAD(+) + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57705", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71759", "l": "2-oxoglutarate(out) + heptanedioate(in) = 2-oxoglutarate(in) + heptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870466", "l": "RGGT:CHM binds RABs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22871", "l": "3-chloro-L-alanine + thioglycolate <=> chloride + H(+) + S-carboxymethyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388814", "l": "Grb2 binds CD28 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30698", "l": "3-aminopropanal + H2O + NAD(+) <=> beta-alanine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77516", "l": "3-methoxybenzaldehyde + hydrogen cyanide => (2S)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783670", "l": "CRLF1 binds CLCF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316349", "l": "RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67036", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 = (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34820", "l": "dihydrocurcumin + NADP(+) => curcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39900", "l": "7-deoxyloganetin + UDP-alpha-D-glucose => 7-deoxyloganin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58864", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176175", "l": "Stalling of DNA replication fork and RPA binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70310", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77289", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371554", "l": "HSF1 acetylation at Lys80 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174124", "l": "Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50348", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74065", "l": "2-aminoisobutanoate(in) + L-alanine(out) => 2-aminoisobutanoate(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450975", "l": "isocitrate <=> citrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70861", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(in) => L-asparagine(in) + L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203893", "l": "Microprocessor complex cleaves pri-miRNA to pre-miRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909721", "l": "Translocation of ISGF3 complex to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24354", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (R)-3-hydroxyhexanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693086", "l": "BACE1(46-501) translocates from Golgi lumen to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047372", "l": "acylglycerol lipase activity", "d": ["Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75346", "l": "adenosine(in) <=> adenosine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40572", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782879", "l": "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67688", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11027", "l": "ATP + NH4(+) <=> ADP + 2 H(+) + phosphoramidate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44957", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH => hexanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120136", "l": "dUMP kinase activity", "d": ["Catalysis of the reaction: ATP + dUMP = ADP + dUDP."], "t": []}, {"i": "RHEA:30655", "l": "ATP + dUMP = ADP + dUDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25598", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43708", "l": "ATP + H(+) + hexadecanoate = diphosphate + hexadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443831", "l": "14-3-3-zeta binds Raf1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29530", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156699", "l": "Inactivation of Wee1 kinase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33074", "l": "D-glucose 6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649657", "l": "NEIL1 recognizes and binds FapyG-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69137", "l": "2 H2O + 2 O2 + spermine => 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65863", "l": "A + Delta(1)-dihydrotestosterone + H2O <=> 17beta-hydroxyandrostan-1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0016427", "l": "tRNA (cytidine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32533", "l": "alpha-D-mannose 1-phosphate + D-glucose => 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.232", "l": "\"15-hydroxyicosatetraenoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48665", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50599", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449978", "l": "IL7 binds IL7R:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480685", "l": "POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55500", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797810", "l": "PTPRD binds IL1RAPL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086059", "l": "voltage-gated calcium channel activity involved SA node cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014449", "l": "RHOG binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70521", "l": "(R)-synephrine + H(+) + S-adenosyl-L-homocysteine => (R)-octopamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51353", "l": "H2O + N-(9Z-octadecenoyl)-L-serine => (9Z)-octadecenoate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035877", "l": "death effector domain binding", "d": ["Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71366", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) <=> 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63429", "l": "ATP + H2O + levoglucosan => ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801101", "l": "RABGGTA binds RABGGTB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66788", "l": "N-methyl-L-dopa + O2 = (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62593", "l": "(S)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047885", "l": "farnesol 2-isomerase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098848", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity", "d": ["Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033457", "l": "GAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38319", "l": "chorismate + H2O = (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": [], "t": []}, {"i": "EC:3.3.2.13", "l": "\"chorismatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10049", "l": "methanethiol + O-acetyl-L-homoserine => acetate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247511", "l": "STAB2:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004028", "l": "3-chloroallyl aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60076", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 = 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52714", "l": "2-deoxy-D-ribose 5-phosphate + thymine => dTMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005139", "l": "interleukin-7 receptor binding", "d": ["Binding to an interleukin-7 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814374", "l": "Kazrin binds periplakin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68971", "l": "mandelate + O2 <=> H2O2 + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031013", "l": "troponin I binding", "d": ["Binding to troponin I, the inhibitory subunit of the troponin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10771", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953339", "l": "DNPH1 hydrolyses dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41514", "l": "H2O + N(5)-hydroxy-L-ornithine + NAD(+) => L-ornithine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72697", "l": "Start codon recognition (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43212", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.230", "l": "\"23S rRNA (adenosine(1067)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60610", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41893", "l": "(3R)-hydroxytetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35311", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) = 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809764", "l": "SBF1 binds MTMR2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27406", "l": "a ubiquinone + H2O + pyruvate => a ubiquinol + acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827994", "l": "SOX17 binds the PDPN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.1", "l": "\"aldehyde oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21536", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.18", "l": "\"methylglutaconyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202127", "l": "eNOS synthesizes NO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50826", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72236", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) => 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53652", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45369", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019133", "l": "choline monooxygenase activity", "d": ["Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661432", "l": "BIL binds ALB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58243", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] <=> ADP-D-ribose + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29833", "l": "Ni(2+)(out) => Ni(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140523", "l": "GTPase-dependent fusogenic activity", "d": ["A GTPase activity that mediates the joining two lipid bilayers to form a single membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59942", "l": "2-methyloctadecanoate + CoA + H(+) => 2-methyloctadecanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875451", "l": "MET phosphorylates CBL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24136", "l": "3'-phosphoadenylyl sulfate + a primary amine = a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.3", "l": "\"amine sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005980", "l": "IL21 binds IL21R:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750226", "l": "NLRC5 binds IKBKB and CHUK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47991", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34433", "l": "(-)-lariciresinol + H(+) + NADPH => (+)-secoisolariciresinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16537", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.76", "l": "\"lipid-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68358", "l": "L-glutamate + N-acetyl-L-aspartate => H2O + N-acetyl-L-aspartyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72697", "l": "UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in) => UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1358789", "l": "Self-ubiquitination of RNF41 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266303", "l": "Spherical HDL binds C and E apolipoproteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005004", "l": "GPI-linked ephrin receptor activity", "d": ["Combining with a GPI-anchored ephrin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34082", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44002", "l": "2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429101", "l": "HMIT co-transports myo-inositol with a proton (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49262", "l": "D-galactose 6-phosphate(in) + L-histidyl-[protein] => D-galactose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35564", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine => (9Z)-hexadecenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74711", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine = 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.387", "l": "\"5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38438", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57304", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35182", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA <=> 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694641", "l": "Viral release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102724", "l": "UDP-glucose:curcumin monoglucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43383", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] <=> L-arginyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004589", "l": "dihydroorotate dehydrogenase (NADH) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + NAD+ = H+ + NADH + orotate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51813", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191971", "l": "THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65602", "l": "2 H(+) + jolkinol C + 2 NADH => 4,5,8-trihydroxycasbene + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222407", "l": "Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11789", "l": "H2O + L-aspartate + NAD(+) => H(+) + NADH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888577", "l": "Synthesis of GABA by GAD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855047", "l": "Hydrolysis of internal thioester in C4b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0017081", "l": "chloride channel regulator activity", "d": ["Binds to and modulates the activity of a chloride channel."], "t": []}, {"i": "REACT:R-HSA-383190", "l": "HCO3- transport through ion channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004077", "l": "biotin-[acetyl-CoA-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27447", "l": "D-xylose + H(+) + NADPH => NADP(+) + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15511", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35790", "l": "paromamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin C + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46613", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19928", "l": "D-ribitol 5-phosphate + NAD(+) <=> D-ribulose 5-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18580", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56107", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 <=> 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31136", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate => 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60821", "l": "H2O + NADPH => adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10946", "l": "phosphate + pseudouridine => H2O + psi-UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867613", "l": "PICALM binds R-SNAREs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18007", "l": "D-erythrulose + H(+) + NADPH => D-threitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102412", "l": "valerena-4,7(11)-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = valerena-4,7(11)-diene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975106", "l": "Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0031877", "l": "somatostatin receptor binding", "d": ["Binding to a somatostatin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74730", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH <=> 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1903962", "l": "arachidonate transmembrane transporter activity", "d": ["Enables the transfer of arachidonate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038036", "l": "sphingosine-1-phosphate receptor activity", "d": ["Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237160", "l": "MTA is cleaved and phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44500", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003940", "l": "L-iduronidase activity", "d": ["Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849463", "l": "PTK6 phosphorylates SFPQ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28566", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP = 6 AMP + enterobactin + 7 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49767", "l": "ethylenediaminetriacetate + FMNH2 + O2 <=> ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40143", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214351", "l": "PLK1 phosphorylates GORASP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686587", "l": "ABL1 phosphorylates RAD52 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39107", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047889", "l": "ferredoxin-nitrate reductase activity", "d": ["Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-374909", "l": "Catabolism of Noradrenaline (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12793", "l": "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389964", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54442", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + H2O => a (4S)-2,3-dehydroflavan-3,4-diol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24335", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate <=> H2O + monacolin L carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810392", "l": "TMEM55B translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209341", "l": "Phosphorylation of SMO by PKA-C1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43103", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) <=> 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56381", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0005085", "l": "guanyl-nucleotide exchange factor activity", "d": ["Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532630", "l": "p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211874", "l": "CYP2S1 4-hydroxylates atRA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74788", "l": "L-histidyl-L-proline diketopiperazine(in) => L-histidyl-L-proline diketopiperazine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51452", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate = beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070273", "l": "phosphatidylinositol-4-phosphate binding", "d": ["Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60906", "l": "13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17184", "l": "a long-chain fatty aldehyde + FMNH2 + O2 <=> a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784462", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5686430", "l": "MUS81 binds EME1, EME2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35143", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.220", "l": "\"2,4,6-trihydroxybenzophenone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22661", "l": "a fatty acid + ATP + holo-[ACP] => a fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72613", "l": "H(+)(in) + L-alanyl-L-lysine(in) => H(+)(out) + L-alanyl-L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68638", "l": "diphosphate + sabinene => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23143", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> D-ribose 5-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13437", "l": "(E)-cinnamate + UDP-alpha-D-glucose = 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.177", "l": "\"cinnamate beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791319", "l": "NID1 degradation by MMP19 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59238", "l": "diphosphate + isoelisabethatriene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42854", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine => 3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16154", "l": "an aliphatic amine + H2O + O2 => an aldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16518", "l": "(R)-1-aminopropan-2-ol + NAD(+) => aminoacetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0035091", "l": "phosphatidylinositol binding", "d": ["Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093342", "l": "SDC2 multimerises (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31012", "l": "(S)-2,3-epoxysqualene => camelliol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11053", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 => 4-aminophenol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47677", "l": "ATP + N-acetyl-D-galactosamine => ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093332", "l": "p-EPHB phosphorylates SDC2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047450", "l": "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity", "d": ["Catalysis of the reaction: (3R)-hydroxybutanoyl-[acyl-carrier-protein] = (2E)-butenoyl-[acyl-carrier-protein] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77191", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21134", "l": "H2O2 + urate => H2O + O2 + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0032036", "l": "myosin heavy chain binding", "d": ["Binding to a heavy chain of a myosin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58518", "l": "15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944219", "l": "Association of procollagen type XVI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45769", "l": "gamma-L-glutamyl-L-alaninol + H2O => L-alaninol + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030332", "l": "cyclin binding", "d": ["Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209960", "l": "Diiodinated tyrosine can be deiodinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76060", "l": "heliamine + S-adenosyl-L-methionine => H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669890", "l": "Constitutive phosphorylation of kinase domain KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12971", "l": "an alcohol + H(+) + sn-glycerol 3-phosphate => a sn-glycero-3-phosphodiester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0031779", "l": "melanocortin receptor binding", "d": ["Binding to a melanocortin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25866", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(1)-acetylspermidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21308", "l": "(S)-2,3-epoxysqualene = cycloartenol", "d": [], "t": []}, {"i": "EC:5.4.99.8", "l": "\"cycloartenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102719", "l": "S-adenosyl-L-methionine:eugenol-O-methyltransferase activity", "d": ["Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653514", "l": "USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13425", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983707", "l": "SYK autophosphorylates at the activated BCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14231", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165195", "l": "GTP loading by Rheb (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68997", "l": "2-oxoglutarate + gibberellin A9 + O2 => CO2 + gibberellin A4 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612501", "l": "SGK phosphorylates CREB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27516", "l": "phosphate + sphinganine => H2O + sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58655", "l": "rifamycin SV ortho-naphthoquinone carboxamide <=> rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110244", "l": "Excision of FapyG by OGG1 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373732", "l": "Nephrin trans-homophilic interaction (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247922", "l": "GGCT transforms gGluCys to OPRO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140031", "l": "phosphorylation-dependent protein binding", "d": ["Binding to a protein upon phosphorylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205319", "l": "Interaction of APS and p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22625", "l": "(S)-4-hydroxy-2-oxopentanoate => acetaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62829", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35159", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68977", "l": "glycoursodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58912", "l": "ATP + H2O + iron(III) dicitrate(out) = ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.18", "l": "\"ABC-type ferric citrate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71165", "l": "H(+)(out) + L-alanine(in) + Na(+)(in) => H(+)(in) + L-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627078", "l": "XIAP binds CASP9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015134", "l": "hexuronate transmembrane transporter activity", "d": ["Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253343", "l": "WWOX binds ERBB4s80 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875661", "l": "GGA3 associates with activated MET receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634916", "l": "CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53883", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate <=> ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070282", "l": "pyridoxine binding", "d": ["Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16879", "l": "CO2 + hypotaurine => 3-sulfino-L-alanine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58070", "l": "acetaldehyde + vanillin => (E)-isoeugenol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55779", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41772", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411402", "l": "Activation of NLK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052833", "l": "inositol monophosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350441", "l": "FLW:MYPT-75D complex dephosphorylates SQH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17730", "l": "an acyl-CoA + cholesterol => a cholesterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74738", "l": "S-adenosyl-L-methionine + syringetin <=> 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173631", "l": "Activation of C1s (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635102", "l": "GPR161 is internalized (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64082", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP] => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65061", "l": "NADP(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735840", "l": "SARS-CoV-1 7a binds BST2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39261", "l": "(2E,13Z)-docosadienoyl-CoA + H2O => (3R)-hydroxy-(13Z)-docosenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624494", "l": "RAF1 binds p21 RAS:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209828", "l": "Tryptophan is hydroxylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795290", "l": "TORC2 complex phosphorylates SGK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17474", "l": "GTP + H2O => 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41823", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716947", "l": "ESR1 binds ESR1 agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021183", "l": "MECP2 mRNA translation is inhibited by miR-132 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41734", "l": "[(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-alpha-D-glucosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33149", "l": "ADP + daunorubicin(out) + H(+) + phosphate => ATP + daunorubicin(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033746", "l": "histone H3R2 demethylase activity", "d": ["Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33814", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine <=> 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13070", "l": "ATP + ethanolamine => ADP + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77561", "l": "a 1,3-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48760", "l": "L-threitol + NAD(+) = H(+) + L-erythrulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52601", "l": "L-methionine + propanoyl-CoA => CoA + H(+) + N-propanoyl-L-methioninate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77352", "l": "2-oxobutanoate + N(omega),N(omega)-dimethyl-L-arginine => (2S)-2-aminobutanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57655", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19074", "l": "ATP + L-seryl-[I-kappa-B protein] => ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944266", "l": "Association of procollagen type XI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951500", "l": "Dissociation of CANX from nonameric complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004157", "l": "dihydropyrimidinase activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190265", "l": "FGFR4 binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19282", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003829", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18131", "l": "a 2-oxocarboxylate + 2 H(+) + NADPH => 2-oxoaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66112", "l": "2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64925", "l": "dATP + 2 H2O => dAMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989748", "l": "Expression of GRHL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64386", "l": "alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine => H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20418", "l": "coelenterazine + O2 => CO2 + coelenteramide + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11514", "l": "H(+) + salicin + UDP => salicyl alcohol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0098632", "l": "cell-cell adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38915", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0034327", "l": "hexanoyltransferase activity", "d": ["Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50281", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60010", "l": "a tRNA with a 3' CC end + 2 diphosphate => a tRNA precursor + 2 CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57765", "l": "2,6-dinitrotoluene + NADH + O2 => 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42909", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA => 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76931", "l": "3-aminobutan-2-ol + H2O + NADP(+) = acetoin + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211904", "l": "CYP4F12 18-hydroxylates ARA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41584", "l": "dimethylallyl diphosphate + L-tyrosine = 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.122", "l": "\"4-O-dimethylallyl-L-tyrosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445699", "l": "ATP Hydrolysis By Myosin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50811", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(S)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0047555", "l": "3',5'-cyclic-GMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047010", "l": "hydroxycyclohexanecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9737780", "l": "MTTP binds lomitapide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65323", "l": "2-oxoglutarate + chrodrimanin E + O2 <=> chrodrimanin A + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368582", "l": "CXXC4 binds DVL to prevent AXIN binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210282", "l": "Interaction of GPVI and FceRI gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46026", "l": "(3R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.423", "l": "\"(1R,2S)-ephedrine 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199935", "l": "MSK1 activates CREB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614933", "l": "ACEIs bind ACE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75963", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52259", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65678", "l": "a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050645", "l": "limonoid glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641134", "l": "SMURF2 binds AXIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43021", "l": "L,L-cystathionine => 2-aminoprop-2-enoate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940959", "l": "Neurolysin degrades neurotensin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71350", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) <=> chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64050", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphinganine => (13Z)-docosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21773", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O => NH4(+) + uridine(6666) in apoB mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694441", "l": "CSNK1D phosphorylates SEC23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65460", "l": "acetyl-CoA + hexan-1-ol = CoA + hexyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202111", "l": "AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25060", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (E)-cinnamate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420131", "l": "The PACAP receptor binds PACAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28599", "l": "H2O + N-acetyl-L-lysine => acetate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873919", "l": "Phosphorylation of JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0033678", "l": "5'-3' DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis."], "t": []}, {"i": "REACT:R-HSA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112430", "l": "Formation of P-TEFb complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56031", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66170", "l": "[protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate => [protein]-with a C-terminal TM segment(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12665", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.81", "l": "\"aminoglycoside N(3)-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606839", "l": "ARSC hydrolyzes steroid sulfates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27495", "l": "3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tricetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391936", "l": "EP1 receptor can bind PGE2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66322", "l": "2',3'-cGAMP(in) => 2',3'-cGAMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696358", "l": "TREM,CD300 binds lipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.112", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58567", "l": "15alpha-stemmadenine + NADP(+) <=> 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53136", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47581", "l": "a ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32559", "l": "(2E)-geranyl diphosphate = diphosphate + gamma-terpinene", "d": [], "t": []}, {"i": "EC:4.2.3.114", "l": "\"gamma-terpinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102515", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose = pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010348", "l": "lithium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13615", "l": "beta-D-fructose 1,6-bisphosphate + H(+) + phosphate => beta-D-fructose 6-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023845", "l": "ESR1:ESTG binds to proximal and distal regions of the CTSD promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-990489", "l": "Kinesin-13 is a dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607058", "l": "Activated protein C:PROCR binds F2R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21482", "l": "5-hydroxy-2-furoyl-CoA + AH2 + H(+) => 2-furoyl-CoA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56135", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA <=> a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47543", "l": "7-oxolithocholate + H(+) + NADPH <=> NADP(+) + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12570", "l": "4-nitrocatechol + H2O + NAD(+) => 4-nitrophenol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69455", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9634834", "l": "ACHEIs bind ACHE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210921", "l": "NEUROG3-dependent synthesis of NKX2-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46340", "l": "ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129357", "l": "Fibrillin C-terminal processing (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983153", "l": "E1 mediated ubiquitin activation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22916", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 = 4-acetoxyphenol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.84", "l": "\"4-hydroxyacetophenone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.161", "l": "\"beta-apiosyl-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62178", "l": "alpha-D-glucose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75218", "l": "beta-L-fucose + NADP(+) <=> H(+) + L-fucono-1,5-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190256", "l": "FGFR1c binds to FGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112037", "l": "Inactivation of PLC beta (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2272753", "l": "Interaction of DAP12 and KIR2DS4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25009", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.195", "l": "\"cinnamyl-alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15377", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.189", "l": "\"autoinducer-2 kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53948", "l": "ATP + holo-[BtrI ACP] + L-glutamate = ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297444", "l": "Binding of cAMP to HCN channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39923", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47707", "l": "H(+) + iso-precytochalasin + NADPH + O2 <=> cytochalasin Z16 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166387", "l": "The FA anion diffuses away laterally from UCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53967", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin <=> gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29622", "l": "alpha-maltotetraose + beta-maltose <=> alpha-maltopentaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53347", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13121", "l": "ATP + shikimate = 3-phosphoshikimate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.71", "l": "\"shikimate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69576", "l": "2-oxoadipate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734572", "l": "Expression of MEF2C in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63231", "l": "ATP + spectinomycin <=> 9-O-adenylylspectinomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38902", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60301", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018681", "l": "deisopropylatrazine monooxygenase activity", "d": ["Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102899", "l": "dehydroabietadienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 = dehydroabietadiene-diol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204485", "l": "Basigin binds CyPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835385", "l": "DUS2 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263495", "l": "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61184", "l": "quercitrin + UDP-beta-L-rhamnose = H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63054", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31683", "l": "prosolanapyrone III = (-)-solanapyrone A", "d": [], "t": []}, {"i": "EC:5.5.1.20", "l": "\"prosolanapyrone-III cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71182", "l": "L-histidine(out) + L-tryptophan(in) <=> L-histidine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1980125", "l": "ITCH binds DTX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10103", "l": "a sterol ester + H2O <=> a fatty acid + a sterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68200", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA = 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31014", "l": "(S)-2,3-epoxysqualene <=> camelliol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605797", "l": "SMPD1 hydrolyzes SPHM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56630", "l": "chloride + 2 H(+) + maleylacetate => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56046", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433940", "l": "Association of LBP with bacterial LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32635", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.84", "l": "\"linalool 8-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140483", "l": "kinetochore adaptor activity", "d": ["The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16367", "l": "2 3,4,5-trihydroxybenzoate + H(+) => digallate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46515", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25410", "l": "ADP + alpha,alpha-trehalose + H(+) => ADP-alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848829", "l": "CBL autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17568", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51523", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45075", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834821", "l": "p-PRKRA dimer binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42506", "l": "6-acetamido-2-oxohexanoate + L-glutamate => 2-oxoglutarate + N(6)-acetyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55592", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O = (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76459", "l": "(E)-sinapyl alcohol + A = (E)-sinapaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77083", "l": "O2 + pre-flavunoidine + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-pre-flavunoidine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865454", "l": "CBFB binds RUNX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418845", "l": "Activation of caspase-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.-", "l": "\"With an nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61992", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42853", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-921155", "l": "p-STAT5 dissociates from the receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70200", "l": "dopaminechrome => 5,6-dihydroxyindole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43937", "l": "androst-5-ene-3,17-dione => androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47838", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP => [5-(aminomethyl)-3-furyl]methyl phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0071771", "l": "aldehyde decarbonylase activity", "d": ["Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875374", "l": "MET binds LRIG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033902", "l": "rRNA endonuclease activity", "d": ["Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58252", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] = ADP-D-ribose + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021919", "l": "MECP2:CREB1 binds SST gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25401", "l": "(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937034", "l": "IRAK1 phosphorylates Pellino (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11194", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49810", "l": "a quinol + butanal => a quinone + butan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042951", "l": "arbutin transmembrane transporter activity", "d": ["Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132047", "l": "Spontaneous hydrolysis of an internal thioester bond in complement factor C3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11304", "l": "(S)-ureidoglycolate = glyoxylate + urea", "d": [], "t": []}, {"i": "EC:4.3.2.3", "l": "\"ureidoglycolate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41697", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71246", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) <=> chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047604", "l": "acetoin racemase activity", "d": ["Catalysis of the reaction: (S)-acetoin = (R)-acetoin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10359", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) <=> 5beta-androstane-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140907", "l": "flavin-dependent halogenase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + FADH2 + O2 = R-C-halogen + FAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.163", "l": "\"1,6-alpha-D-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36851", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32281", "l": "(S)-ureidoglycolate + CO2 + 2 NH4(+) => allantoate + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35807", "l": "2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.141", "l": "\"2-dehydro-3-deoxy-D-arabinonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944216", "l": "Association of procollagen type XV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018826", "l": "RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15207", "l": "a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+) => a dolichyl diphosphooligosaccharide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34968", "l": "sn-glycerol 3-phosphate(in) => sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62574", "l": "glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61251", "l": "H2O + L-tyrosine + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014454", "l": "RHOG translocates to the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51560", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine = (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27650", "l": "GTP + uridine = GDP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856189", "l": "TNFSF8 binds TNFRSF8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15165", "l": "H2O + O2 + sarcosine = glyoxylate + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16855", "l": "AMP + fumarate => N(6)-(1,2-dicarboxyethyl)-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69140", "l": "N-(4-aminobutyl)-3-aminopropanal = acrolein + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782138", "l": "ERCC5 and RPA bind TC-NER site (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67096", "l": "2-oxoglutarate + asnovolin A + 2 O2 = CO2 + fumigatonoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209792", "l": "N-acetylation of serotonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.79", "l": "\"pappalysin-1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43436", "l": "coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.15", "l": "\"coproporphyrinogen III oxidase (coproporphyrin-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20643", "l": "3 H(+) + L-histidine + 2 NADH => H2O + L-histidinol + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38505", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18828", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64543", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106140", "l": "P-TEFb complex binding", "d": ["Binding to a P-TEFb complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.142", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14800", "l": "2-dehydro-3-deoxy-D-gluconate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24639", "l": "H2 + NAD(+) <=> H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46123", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16167", "l": "CO2 + H2O + indole-3-acetamide => L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390595", "l": "Calcium Binds Troponin-C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36577", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70598", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.8", "l": "\"ribosylpyrimidine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198211", "l": "Active TRKA binds IRS1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016158", "l": "3-phytase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129353", "l": "Tropoelastin associates with microfibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389354", "l": "Activation of Vav1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56205", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102160", "l": "cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate = H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73499", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54797", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) => an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36827", "l": "dioscin + 3 H2O = D-glucose + diosgenin + 2 L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:3.2.1.189", "l": "\"dioscin glycosidase (diosgenin-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34869", "l": "AMP + diphosphate + thiophene-2-carbonyl-CoA => ATP + CoA + thiophene-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31734", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50446", "l": "prostaglandin G3 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56596", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 = (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.155", "l": "\"3,6-diketocamphane 1,2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174444", "l": "Formation of C-strand Okazaki fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879562", "l": "SLCO2B1 has a narrow substrate specificity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592247", "l": "Expression of ATP5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442749", "l": "CaMKK autophosphorylates in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17953", "l": "3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": [], "t": []}, {"i": "EC:1.13.11.6", "l": "\"3-hydroxyanthranilate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72722", "l": "eIF2 activation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688786", "l": "ATXN3 binds RAD23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102321", "l": "2,2'-hydroxybiphenyl monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ = biphenyl-2,2',3-triol + H2O + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.10", "l": "\"N-acetylglucosaminide alpha-(2,6)-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0005509", "l": "calcium ion binding", "d": ["Binding to a calcium ion (Ca2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706287", "l": "Active FLT3 binds to ABL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54066", "l": "10-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35547", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.70", "l": "\"mycocyclosin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69020", "l": "L-aspartate + NADPH + O2 = H2O + N-hydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.2", "l": "\"4-hydroxybenzoate 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65398", "l": "8-oxo-dAMP + diphosphate + H(+) => 8-oxo-dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76813", "l": "1-hydroxy-4-(methythio)butan-2-one + H(+) + NADH + NH4(+) => (S)-methioninol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54201", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190263", "l": "FGFR3b binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72621", "l": "Ribosomal scanning  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57808", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58757", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74230", "l": "H2O + L-threonyl-tRNA(Ile) <=> L-threonine + tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60845", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56163", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate <=> an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16082", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O => (2R)-S-methyl-1-thioglycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76586", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADH <=> (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60006", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112755", "l": "SOCS3 binds IL6ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010435", "l": "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381727", "l": "RAP1A exchanges GDP for GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418456", "l": "cGMP is degraded by PDEs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047635", "l": "alanine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54063", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2Z,6E)-hedycaryol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350598", "l": "Arginine<=>Agmatine+CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211224", "l": "Anthrax cya catalyzes the conversion of ATP to cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791235", "l": "GADD45A binds AURKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32483", "l": "H(+) + H2O + pheophorbide a = CO2 + methanol + pyropheophorbide a", "d": [], "t": []}, {"i": "EC:3.1.1.82", "l": "\"pheophorbidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59387", "l": "2-oxoglutarate + 4-amino-L-phenylalanine <=> 3-(4-aminophenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218836", "l": "PTK2beta binds alphaVbeta3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42201", "l": "corticosterone + NADP(+) => 11-dehydrocorticosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69805", "l": "benzoyl-AMP + diphosphate => ATP + benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.214", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41592", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54618", "l": "2-hydroxyheptadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + heptadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784959", "l": "BPHL hydrolyses VACV to ACV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000269", "l": "toxin export channel activity", "d": ["Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23880", "l": "L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": [], "t": []}, {"i": "EC:2.7.3.9", "l": "\"phosphoenolpyruvate--protein phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30825", "l": "H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690196", "l": "USP8 deubiquitinates RNF128 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483219", "l": "PC is exchanged with PI by PITPNB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189069", "l": "sucrose + H2O => glucose + fructose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507869", "l": "Aquaporins passively transport glycerol into cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174916", "l": "Formation of N-glucuronides (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371353", "l": "Soluble TNF-α binds TNFR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.38", "l": "\"isonocardicin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16834", "l": "2 glutathione + H2O2 => glutathione disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351208", "l": "Spermidine  => N-acetylated spermidine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850961", "l": "PREX2 binds PTEN and inhibits it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18722", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => diphosphate + ent-13-epi-manoyl oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45015", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749487", "l": "TP53 stimulates IKBIP gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41670", "l": "chelirubine + NADPH => dihydrochelirubine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75757", "l": "10-hydroxyoctadecanoate => (10E)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848395", "l": "IL18:IL18R1 binds IL18RAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41874", "l": "(3R)-hydroxydodecanoyl-[ACP] + NADP(+) => 3-oxododecanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0003955", "l": "NAD(P)H dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77308", "l": "N(omega),N('omega)-dimethyl-L-arginine + pyruvate => 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49226", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60663", "l": "1,4-benzoquinone + H(+) + NADH <=> hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68618", "l": "cortisol + NADP(+) => cortisone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420274", "l": "GIP receptor binds gastric inhibitory peptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58806", "l": "5'-ApG-3' + phosphate => 5'-pApG-3' + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450466", "l": "AUF1:mRNA complex is destroyed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0017147", "l": "Wnt-protein binding", "d": ["Binding to a Wnt-protein, a secreted growth factor involved in signaling."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28171", "l": "(2R)-2-hydroxy-2-methylbutanenitrile => butan-2-one + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20353", "l": "A + chloride + H(+) + trichloroethene = AH2 + tetrachloroethene", "d": [], "t": []}, {"i": "EC:1.21.99.5", "l": "\"tetrachloroethene reductive dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694583", "l": "ABHD4 hydrolyses NAPE (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32922", "l": "H2O + methyl (indol-3-yl)acetate <=> (indol-3-yl)acetate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25919", "l": "A + H2O + quinolin-6-ol <=> 6-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-593685", "l": "Netrin-4 binds DCC/UNC5A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74760", "l": "isorhamnetin + S-adenosyl-L-methionine => 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69830", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047696", "l": "beta-adrenergic receptor kinase activity", "d": ["Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963915", "l": "1,25(OH)2D binds VDR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61134", "l": "CO2 + H(+) + H2O + kaempferol + succinate => (2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683634", "l": "Dimerisation of nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299297", "l": "Activation of THIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63479", "l": "NADP(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804762", "l": "TP53 forms homotetramers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830284", "l": "Protein M2-1 tetramers bind protein P tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16186", "l": "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031831", "l": "type 5B serotonin receptor binding", "d": ["Binding to a type 5B serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72713", "l": "4,21-dehydrogeissoschizine => cathenamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811479", "l": "ING2 recruits EP300 to TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28414", "l": "gamma-L-glutamylputrescine + H2O + O2 = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070506", "l": "high-density lipoprotein particle receptor activity", "d": ["Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193695", "l": "IRAK interacts with TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25718", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69384", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) = (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": [], "t": []}, {"i": "EC:2.1.1.383", "l": "\"L-carnitine--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73697", "l": "dADP(in) + H(+)(in) + phosphate(out) => dADP(out) + H(+)(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140473", "l": "telomere-nuclear envelope anchor activity", "d": ["The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61233", "l": "H2O + L-isoleucine + O2 => (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44407", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70692", "l": "ornithine => putrescine + CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38458", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34954", "l": "3-hydroxypropanoate(out) <=> 3-hydroxypropanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29424", "l": "ATP + diphosphate => ADP + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874849", "l": "CREBRF binds CREB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209910", "l": "Iodide is taken up by thyroid epithelial cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003841", "l": "1-acylglycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174367", "l": "GCL ligates L-Glu to L-Cys (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34723", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O = 15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0016615", "l": "malate dehydrogenase activity", "d": ["Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9669893", "l": "KIT binds type I TKIs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692764", "l": "MAPK6 binds CCND3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49375", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate <=> H2O + NAD(+) + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39058", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602050", "l": "Defective CYP26C1 does not 4-hydroxylate 9cRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45122", "l": "H(+) + ipsdienone + NADH => (4R)-ipsdienol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13158", "l": "(R)-glycerate + CO2 + NADP(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.179", "l": "\"methylxanthine N(3)-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437230", "l": "L1-FGFR cis-heterodimerization (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140941", "l": "histone H4K20me methyltransferase activity", "d": ["Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethlyated lysine residue at position 20 of histone H4, producing H4K20me2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46622", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10322", "l": "1-pyrroline-2-carboxylate + H2O => trans-3-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299297", "l": "Activation of THIK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218824", "l": "p-6Y-VEGFR2 binds FYN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15901", "l": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65130", "l": "1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660840", "l": "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21095", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine <=> dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38182", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102731", "l": "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70984", "l": "glycine(out) + n H(+)(in) => glycine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31551", "l": "presqualene diphosphate = 15-cis-4,4'-diapophytoene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592240", "l": "Formation of NRF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.281", "l": "\"GDP-4-dehydro-6-deoxy-D-mannose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29440", "l": "Fe(2+)(in) + H(+)(out) => Fe(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29374", "l": "dAMP + H2O <=> 2'-deoxyadenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174367", "l": "GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61749", "l": "rubusoside + UDP-alpha-D-glucose => H(+) + stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72792", "l": "bilirubin-glucuronoside(out) => bilirubin-glucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-390329", "l": "Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61237", "l": "H2O + L-methionine + O2 => 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174058", "l": "Degradation of multiubiquitinated Cdh1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265456", "l": "NPC1L1 binds ezetimibe (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13101", "l": "4-imidazolone-5-propanoate = H2O + trans-urocanate", "d": [], "t": []}, {"i": "EC:4.2.1.49", "l": "\"urocanate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64113", "l": "an N-acyl-L-phenylalanine + H2O => a fatty acid + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41912", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694337", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49239", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose <=> L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167056", "l": "SHC binds to the activated TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052578", "l": "alpha-farnesene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50762", "l": "a quinol + sulfate => a quinone + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73100", "l": "3'-dephospho-CoA(in) + AMP(out) => 3'-dephospho-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40259", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69299", "l": "CDT1 binds geminin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635102", "l": "GPR161 is internalized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15842", "l": "D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17050", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66238", "l": "H2O2 + IC-asc-DeltaC9-CoA => IC-asc-C9-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640195", "l": "RRAGA,B hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77143", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56346", "l": "a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP => a 7-hydroxyisoflavone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220611", "l": "Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036373", "l": "L-fucose mutarotase activity", "d": ["Catalysis of the reaction: alpha-L-fucose = beta-L-fucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18988", "l": "chorismate <=> isochorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.5", "l": "\"tyrosine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20413", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine = glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.112", "l": "\"glucuronoxylan 4-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71757", "l": "2-oxoglutarate(in) + 2-oxoheptanedioate(out) => 2-oxoglutarate(out) + 2-oxoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64219", "l": "2-carboxy-L-lyxonate + H(+) <=> CO2 + L-lyxonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.4", "l": "\"dipeptidyl-peptidase III\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16010", "l": "ATP + formate => ADP + formyl phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15431", "l": "5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine => heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37248", "l": "H2O + thymidine 3'-monophosphate => phosphate + thymidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60895", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O <=> a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9008043", "l": "MAPK8 phosphorylation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58360", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68019", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15756", "l": "GTP + IMP + L-aspartate <=> GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66475", "l": "(2Z,6E,10E,14E)-geranylfarnesol <=> 18-episcalar-17(25)-en-19-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73167", "l": "CoA(out) + NAD(+)(in) = CoA(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674531", "l": "AAMP binds EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49494", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033969", "l": "gamma-glutamyl-gamma-aminobutyrate hydrolase activity", "d": ["Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46706", "l": "2-hydroxybenzoyl-5'-AMP + diphosphate => ATP + H(+) + salicylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061483", "l": "sulfinylpropanyl adenylate synthase", "d": ["Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228578", "l": "tetX LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31970", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35131", "l": "H(+)(out) + L-alanyl-L-glutamate(out) = H(+)(in) + L-alanyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75946", "l": "beta-alanine + L-arginine <=> 3-guanidinopropanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64917", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692880", "l": "HRH3 binds Hist (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050429", "l": "calcium-dependent phospholipase C activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362427", "l": "Hh-Np binds GPC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50772", "l": "H2O + nitroethane + O2 = acetaldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66335", "l": "L-aspartate(out) <=> L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0008920", "l": "lipopolysaccharide heptosyltransferase activity", "d": ["Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72918", "l": "D-fructopyranose(out) + Na(+)(out) <=> D-fructopyranose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54459", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870461", "l": "RABGGTA and RABGGTB bind (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050626", "l": "trimethylamine-N-oxide reductase (cytochrome c) activity", "d": ["Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46012", "l": "(S)-malate + a quinone = a quinol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77335", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534359", "l": "CatSper Channel Mediated Calcium Transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39935", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74740", "l": "Binding of SHC1 to insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867047", "l": "PTPN3 dephosphorylates EPS15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73368", "l": "D-xylose(out) + 2 Na(+)(out) => D-xylose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052762", "l": "gellan lyase activity", "d": ["Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73146", "l": "CoA(out) + FAD(in) <=> CoA(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32305", "l": "(2R,3S)-homoisocitrate => (2R)-homocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682967", "l": "WHSC1 binds DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41279", "l": "H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163310", "l": "TFAM binds to mitochondrial promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55539", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694454", "l": "Replication transcription complex binds SARS-CoV-2 genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59840", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018716", "l": "1-phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68146", "l": "ethyl (R)-3-hydroxybutanoate + NADP(+) => ethyl 3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814409", "l": "CK2 phosphorylates PDCL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15998", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654404", "l": "Activated FGFR2 binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73188", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate => (2R,3S,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71016", "l": "H2O + N-methylputrescine + O2 => 4-methylaminobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55964", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51638", "l": "a quinol + selenate => a quinone + H2O + selenite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21519", "l": "isopiperitenone <=> piperitenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25950", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+) => a 1,2-diacyl-sn-glycerol + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69116", "l": "glyoxylate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694721", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48331", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008311", "l": "double-stranded DNA 3'-5' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76306", "l": "L-cystine(out) <=> L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30850", "l": "FAD + glutaryl-CoA + 2 H(+) <=> (2E)-butenoyl-CoA + CO2 + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70518", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.262738290078808", "identifiers": [{"i": "GO:0004672", "l": "protein kinase activity", "d": ["Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62262", "l": "2 hydrogencarbonate(in) + Mn(2+)(in) => 2 hydrogencarbonate(out) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10193", "l": "ATP + H2O + sulfate(out) => ADP + H(+) + phosphate + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61392", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253343", "l": "WWOX binds ERBB4s80 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682598", "l": "ATM phosphorylates HERC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58734", "l": "5-methyl-CMP + diphosphate + H(+) => 5-methyl-CTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48639", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866851", "l": "CFTR transits to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390846", "l": "D2D3,4 bind to DA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032181", "l": "dinucleotide repeat insertion binding", "d": ["Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30602", "l": "15-cis-phytoene + 3 A <=> 3 AH2 + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38695", "l": "a cardiolipin(in) = a cardiolipin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52771", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O <=> 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429730", "l": "PPM1L dephosphorylates multiphospho-CERT1-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937369", "l": "ATAD2 binds ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.-", "l": "\"Dipeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679839", "l": "RIPK1 binds ponatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.7", "l": "\"cyclic alcohol dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59279", "l": "L-glutamine <=> D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033437", "l": "ACU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19072", "l": "(R)-S-lactoylglutathione <=> glutathione + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170846", "l": "TGFBR2 recruits TGFBR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27360", "l": "iodide + S-adenosyl-L-methionine <=> iodomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.53", "l": "\"sialate O-acetylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32435", "l": "dihydrocarvone + H(+) + NADPH + O2 = 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76860", "l": "3-aminopentane + H2O + NAD(+) => H(+) + NADH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901359", "l": "tungstate binding", "d": ["Binding to tungstate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68057", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18396", "l": "(R)-3-amino-2-methylpropanoate + pyruvate <=> 2-methyl-3-oxopropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656261", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174731", "l": "Degradation of newly synthesized ApoB-48 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60278", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33091", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19160", "l": "D-xylonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67909", "l": "a primary linear alkyl sulfate ester + H2O => a primary alcohol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70661", "l": "H(+)(out) + N,N-dimethylglycine(out) => H(+)(in) + N,N-dimethylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378975", "l": "Follitropin is a heterodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0001050", "l": "single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51786", "l": "deoxyhumulone + diphosphate => 4-prenylphlorisovalerophenone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64618", "l": "(E)-coniferyl acetate + CoA => (E)-coniferol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0000099", "l": "sulfur amino acid transmembrane transporter activity", "d": ["Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.-", "l": "\"Protein-tyrosine kinases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419389", "l": "LPA-binding receptors bind LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37730", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51521", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483174", "l": "PE is methylated to PC by PEMT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66381", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O => ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27790", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68600", "l": "(2S)-3-sulfopropanediol = 3-oxopropane-1-sulfonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.177", "l": "\"(2S)-3-sulfopropanediol dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70728", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O => 6-sulfo-alpha-D-quinovose + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729330", "l": "SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63380", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57583", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thiol-D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27575", "l": "(3R)-piperidine-3-carboxamide + H2O => (3R)-piperidine-3-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29461", "l": "beta-alanine(out) + H(+)(out) => beta-alanine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60650", "l": "an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine => an N-(acyl)-sphingosylphosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48611", "l": "A + a 2,3-saturated acyl-CoA <=> a 2,3-dehydroacyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72873", "l": "anthocyanin A5 + CoA => anthocyanin A3 + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16980", "l": "acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.30", "l": "\"acyl-lipid (8-3)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71791", "l": "(R)-lactate(in) + H(+)(in) = (R)-lactate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11479", "l": "glycerol 1-phosphate + H2O <=> glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41392", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202534", "l": "Ubiquitination of NEMO by TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67633", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] => a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854466", "l": "VLDLR binds RELN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0005345", "l": "purine nucleobase transmembrane transporter activity", "d": ["Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22689", "l": "D-alanine + H2O + O2 => H2O2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73797", "l": "FAICAR => IMP + H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64296", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH = (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68555", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10070", "l": "4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218804", "l": "p38 MAPK activation by VEGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75188", "l": "2,5-dihydroxybenzoyl-CoA + H2O => 2,5-dihydroxybenzoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445072", "l": "Interaction of PAK1 with Rac1-GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64183", "l": "an N-(fatty acyl)-L-tryptophan + H2O <=> a fatty acid + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35272", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13621", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": [], "t": []}, {"i": "EC:5.4.99.15", "l": "\"(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14629", "l": "ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate", "d": [], "t": []}, {"i": "EC:2.7.2.8", "l": "\"acetylglutamate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.126", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30878", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9846477", "l": "A4GALT transfers galactose to LacCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36985", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14003", "l": "CoA + glycocholate + H(+) => choloyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797100", "l": "CCNK binds CDK13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23277", "l": "2-dehydropantoate => 3-methyl-2-oxobutanoate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11876", "l": "NAD(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.141", "l": "\"15-hydroxyprostaglandin dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695964", "l": "ABHD14B hydrolyses PNPB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373724", "l": "Nephrin binds NCK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047704", "l": "bile-salt sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72536", "l": "H2O + NADP(+) + vanillin => 2 H(+) + NADPH + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2512800", "l": "SCARB1:ligand is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9681616", "l": "AP2 binds chlorpromazine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58282", "l": "cyclic tetraadenylate + 4 diphosphate => 4 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47457", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) => 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445704", "l": "Calcium Binds Caldesmon (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16703", "l": "estrone + H(+) + NADH => 17alpha-estradiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801641", "l": "TP53 binds the PLK2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254251", "l": "ERBB4s80 binds YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69016", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55390", "l": "(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-2,3-dihydrotabersonine + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16920", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 <=> 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47287", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13720", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672969", "l": "Phosphorylation of RAF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25431", "l": "ATP + N-acetyl-D-hexosamine <=> ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72145", "l": "3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + GTP + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77609", "l": "Binding of APOBEC-1 to form editosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28177", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> colneleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709547", "l": "ESTG binds ESR2:chaperone complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047451", "l": "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + (2E)-octenoyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434700", "l": "STIM1 activation of CRAC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70741", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50197", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005047", "l": "signal recognition particle binding", "d": ["Binding to a signal recognition particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769419", "l": "NPAS4 binds RET gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27815", "l": "acetate(in) + Na(+)(in) => acetate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49923", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28994", "l": "N-acetylneuraminate(in) <=> N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164832", "l": "ATPase synthesizes ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69650", "l": "H2O + quercetin 4'-O-beta-D-glucoside <=> beta-D-glucose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102772", "l": "sphingolipid C4-monooxygenase activity", "d": ["Catalysis of the reaction: a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67604", "l": "H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40863", "l": "FAD + H(+) + heptadecanoyl-CoA = FADH2 + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66174", "l": "H(+)(in) + L-cystine(in) => H(+)(out) + L-cystine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637798", "l": "Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209891", "l": "Dopamine is oxidised to noradrenaline (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10932", "l": "ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.4.5", "l": "\"argininosuccinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33676", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26474", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:2.4.1.247", "l": "\"beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51495", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57343", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59264", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11457", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52734", "l": "adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+) => 3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61760", "l": "rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473184", "l": "Follistatin (FST) binds Activin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782895", "l": "TYW1:FMN:4Fe-4S  transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20405", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.47", "l": "\"N-acetyldiaminopimelate deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57928", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.13", "l": "\"lipid II isoglutaminyl synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12002", "l": "CO2 + NADPH => formate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22174", "l": "H(+) + sucrose 6(F)-phosphate + UDP => beta-D-fructose 6-phosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52892", "l": "H2O + NADP(+) + nitrosobenzene = H(+) + NADPH + nitrobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801666", "l": "PLK2 phosphorylates CENPJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004346", "l": "glucose-6-phosphatase activity", "d": ["Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433451", "l": "JAK2 binds to p-KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265456", "l": "NPC1L1 binds ezetimibe (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160154", "l": "tRNA pseudouridine(38/39) synthase activity", "d": ["Catalysis of the reaction: uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55781", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate => all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-532549", "l": "MPI isomerises Fru6P to Man6P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374664", "l": "Phosphorylation and activation of Ezrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.11", "l": "\"galactosylceramide sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671772", "l": "p-T38-PPP1R14A binds MLCP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22437", "l": "(2E,6E)-farnesyl diphosphate + H2O => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71644", "l": "guanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59456", "l": "NADP(+) + tetradecan-1-ol = H(+) + NADPH + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052757", "l": "chondroitin hydrolase activity", "d": ["Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654515", "l": "KAL1 binds HS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35291", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63117", "l": "peroxynitrite => nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111956", "l": "Calmodulin activates Cam-PDE 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664850", "l": "ATM binds PEX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047470", "l": "(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity", "d": ["Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29359", "l": "H2O + UMP = phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0086089", "l": "voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37760", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11991", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72103", "l": "Formation of pre-mRNPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21839", "l": "D-arabinonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53633", "l": "(2E,6E)-farnesyl diphosphate => (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14743", "l": "4-methylene-L-glutamate + NH4(+) => 4-methylene-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050328", "l": "tetrahydroberberine oxidase activity", "d": ["Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663194", "l": "Some pathogenic BRCA1 mutants do not bind BARD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49832", "l": "a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48690", "l": "D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl => H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45244", "l": "(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39796", "l": "7beta-hydroxycholesterol(in) + ATP + H2O => 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630053", "l": "NTHL1 D239Y does not cleave thymine glycol (Tg) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65573", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27854", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.93", "l": "\"4-hydroxybenzoate geranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024726", "l": "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73834", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451418", "l": "Pellino ubiquitinates IRAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036020", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)8 (PP-Dol)1 by ALG9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22561", "l": "(3R)-vestitone + NADP(+) => 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004464", "l": "leukotriene-C4 synthase activity", "d": ["Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59066", "l": "luteothin + S-adenosyl-L-homocysteine => demethylluteothin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60757", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone => cinerin I + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38078", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48453", "l": "a ganglioside GA2 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70085", "l": "H2O + o-quinone methide => hydroxyclavatol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54569", "l": "a uridine in rRNA => a pseudouridine in rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45636", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52300", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10357", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) => 5beta-androstane-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2248891", "l": "M6PR transports activated ARSA to the lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34038", "l": "O2 + paromamine <=> 6'-oxoparomamine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18870", "l": "ATP + L-xylulose => ADP + H(+) + L-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23131", "l": "4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19745", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine", "d": [], "t": []}, {"i": "EC:1.21.99.4", "l": "\"thyroxine 5'-deiodinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17737", "l": "NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050437", "l": "(-)-endo-fenchol synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679205", "l": "ULK1 phosphorylates Beclin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9833777", "l": "PKR binds activating host RNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799097", "l": "ATM phosphorylates ZNF420 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65501", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53670", "l": "(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004130", "l": "cytochrome-c peroxidase activity", "d": ["Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12403", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> NH4(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36585", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => dTDP-alpha-D-fucose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912364", "l": "MIR181C microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990919", "l": "proteasome-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39867", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61824", "l": "pregnenolone + UDP-alpha-D-glucose = H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25530", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54376", "l": "(+)-copalyl diphosphate + H2O = diphosphate + nezukol", "d": [], "t": []}, {"i": "EC:4.2.3.183", "l": "\"nezukol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25562", "l": "9beta-pimara-7,15-diene + diphosphate => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46326", "l": "3-oxochola-4,17-dien-22-oyl-CoA + AH2 => 3-oxochol-4-en-22-oyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74280", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA => a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672168", "l": "Ligand-independent dimerization of PDGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30608", "l": "A + all-trans-phytofluene => AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40233", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097007", "l": "4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity", "d": ["Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74092", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20523", "l": "acetoacetate + H(+) + NADH => (R)-3-hydroxybutanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853496", "l": "SCF:FBXL7 binds AURKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69223", "l": "a (Z)-glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18319", "l": "a D-alpha-amino acid => an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694441", "l": "CSNK1D phosphorylates SEC23 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299297", "l": "Activation of THIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73845", "l": "a sterol 27-beta-D-glucoside + H(+) + UDP => a 27-hydroxysterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40784", "l": "docosanoyl-CoA + H2O => CoA + docosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46629", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH => androst-5-en-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58102", "l": "(15Z)-tetracosenoate + glycerol + H(+) => 1-(15Z-tetracosenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373747", "l": "Phosphorylation of nephrin by FYN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35693", "l": "1'-hydroxyversicolorone + H(+) + NADPH => (2S)-versicolorone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77529", "l": "(2S)-2-hydroxyheptanenitrile => hexanal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30491", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033164", "l": "glycolipid 1,6-alpha-mannosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340214", "l": "CYGB binds O2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.94", "l": "\"proprotein convertase 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032139", "l": "dinucleotide insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430308", "l": "PARVB interacts with Alpha-actinin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60327", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22715", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) <=> adenosylcob(III)inamide-GDP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73337", "l": "AMP + beta-alanyl-tryptamine + diphosphate + H(+) => ATP + beta-alanine + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76054", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218805", "l": "PKC autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2250301", "l": "Formation of lysyl-pyrrole cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48327", "l": "a ganglioside GD1b + GDP-beta-L-fucose <=> a ganglioside Fuc-GD1b + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035478", "l": "chylomicron binding", "d": ["Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63764", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015408", "l": "ABC-type ferric iron transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61745", "l": "steviolbioside + UDP-alpha-D-glucose => stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849882", "l": "SALMs 1-4 bind reticulon 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32831", "l": "an R-cob(III)alamin(in) = an R-cob(III)alamin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14507", "l": "glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite => 2 glutathione + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53442", "l": "18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166220", "l": "FA anion diffuses laterally to UCP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354124", "l": "Phosphorylation of pPTK2 by SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429955", "l": "CCR4-NOT complex deadenylates mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59004", "l": "dodecanal + H2O + O2 = dodecanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420117", "l": "VEGFR2 autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58082", "l": "docosanoate + glycerol + H(+) => 1-docosanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034779", "l": "4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70499", "l": "D-galactose(out) + 2 Na(+)(out) = D-galactose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67330", "l": "trichosetin => (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45202", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51144", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 = (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38031", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450488", "l": "BRF1 Complex recruits RNA degradation activities (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191656", "l": "Closure of gap junction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0034185", "l": "apolipoprotein binding", "d": ["Binding to an apolipoprotein, the protein component of a lipoprotein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043422", "l": "protein kinase B binding", "d": ["Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193068", "l": "CYP17A1 17-hydroxylates PREG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66992", "l": "3-methylpentanoate + ATP + CoA = 3-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42277", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60565", "l": "2-deoxy-D-glucose + ATP => 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15004", "l": "keto-L-sorbose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11840", "l": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.28", "l": "\"benzaldehyde dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019178", "l": "NADP phosphatase activity", "d": ["Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37259", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) = 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16858", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008802", "l": "betaine-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592240", "l": "Formation of NRF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17735", "l": "CO2 + pyruvate => acetylenedicarboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56492", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39057", "l": "22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875183", "l": "CBL monoubiquitinates activated MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43549", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928614", "l": "EFNB:GRB4 binds GIT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61473", "l": "a sphingoid base + hexadecanoyl-CoA => an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70237", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140753", "l": "linear 1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a linear [(1->3)-beta-D-glucosyl](n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12829", "l": "(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.2", "l": "\"methylaspartate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47804", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42103", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160097", "l": "reverse gyrase activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle, is driven by ATP hydrolysis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28956", "l": "aldehydo-D-glucuronate(in) + H(+)(in) => aldehydo-D-glucuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67761", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46715", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52948", "l": "deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69913", "l": "adenosine(in) + 2 Na(+)(in) => adenosine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49133", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72483", "l": "(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448741", "l": "IL22RA2 binds IL22 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43558", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42948", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21820", "l": "L-homocysteine + S-adenosyl-L-methionine = H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41671", "l": "dihydrochelirubine + NADP(+) <=> chelirubine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047384", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity", "d": ["Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47102", "l": "CoA + H(+) + taurocholate => choloyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46975", "l": "A + dihydrobisanhydrobacterioruberin <=> AH2 + bisanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182988", "l": "Sprouty lures CBL away from EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62211", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014467", "l": "RHOG binds effectors at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17333", "l": "O-acetyl-L-serine + zeatin = acetate + H(+) + L-lupinate", "d": [], "t": []}, {"i": "EC:2.5.1.50", "l": "\"zeatin 9-aminocarboxyethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614460", "l": "Dimerization of procollagen type VI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61411", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38380", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802915", "l": "Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042497", "l": "triacyl lipopeptide binding", "d": ["Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395784", "l": "Nascent CMs transform into mature CMs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61841", "l": "brassicasterol + UDP-alpha-D-glucose => brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015450", "l": "protein-transporting ATPase activity", "d": ["Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated."], "t": []}, {"i": "REACT:R-HSA-1222523", "l": "SodB gets secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.104", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213244", "l": "Loading of antigenic peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008043", "l": "MAPK8 phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22364", "l": "L-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68615", "l": "Formation of ORC(1-6) complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54730", "l": "malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41043", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29021", "l": "D-galactose(out) + H(+)(out) => D-galactose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74709", "l": "5-dehydrofumagillol + H(+) + NADPH => fumagillol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41268", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35140", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + demethoxycurcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51902", "l": "acetate + spermidine => H2O + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018553", "l": "3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0043225", "l": "ATPase-coupled inorganic anion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28024", "l": "AMP + diphosphate + octanoyl-[ACP] => ATP + holo-[ACP] + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374680", "l": "L1 trans-homophilic interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34830", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 <=> H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617828", "l": "TRIP11:IFT20 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33547", "l": "H2O + lanosteryl hexadecanoate = H(+) + hexadecanoate + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801195", "l": "STEAP3 binds BNIP3L (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58521", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624112", "l": "CEBPA binds CDK4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69991", "l": "3-dehydro-6-deoxoteasterone + NADP(+) = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75178", "l": "dATP + NAD(+) <=> dADP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43678", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44304", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA = a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37288", "l": "ATP + H2O + L-alanyl-L-leucine(out) => ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55193", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 => 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201669", "l": "Beta-catenin translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76053", "l": "(S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74277", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420688", "l": "GABAB heterodimeric receptor binds GABA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203774", "l": "Interaction of Csk with PAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296045", "l": "Activation of Potassium transport channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033770", "l": "2-hydroxyisoflavanone synthase activity", "d": ["Catalysis of the reactions: liquiritigenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase] and (2S)-naringenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37540", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9671145", "l": "DKC1 binds SHQ1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40199", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166792", "l": "Conversion of C2 into C2a and C2b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869568", "l": "NPM1 binds TFAP2A homodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004155", "l": "6,7-dihydropteridine reductase activity", "d": ["Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102930", "l": "4-hydroxybenzoate geranyltransferase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727284", "l": "9b forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190265", "l": "FGFR4 binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390929", "l": "HTR1 and 5A receptors can bind serotonin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53667", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) <=> H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43733", "l": "a triacyl-sn-glycerol + H2O => a 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033822", "l": "glucosyl-DNA beta-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71403", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852324", "l": "GTSE1 binds PLK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44772", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.22", "l": "\"rRNA N-glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692738", "l": "HRH2 binds HRH2 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51614", "l": "(R)-malate + 2-oxoglutarate => (R)-2-hydroxyglutarate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40338", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008961", "l": "phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity", "d": ["Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54050", "l": "4-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149519", "l": "MMACHC decyanates CNCbl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828718", "l": "NS2 (1B) mRNA is translated into protein NS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45041", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980061", "l": "JAG2 binds NOTCH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008424", "l": "glycoprotein 6-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61431", "l": "cis-trans-nepetalactol + NAD(+) <=> cis-trans-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879942", "l": "The receptor is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102178", "l": "4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH = 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61085", "l": "(2S)-naringenin + 2-oxoglutarate + O2 => (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170020", "l": "ionotropic olfactory receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific odorant has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68347", "l": "ATP + GTP <=> 3',2'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17524", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) <=> ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20058", "l": "2 H(+) + H2O + N-carbamoylsarcosine => CO2 + NH4(+) + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58396", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35712", "l": "acetate + succinyl-CoA => acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693125", "l": "RHOF binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15578", "l": "H2O + uridine => D-ribose + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669878", "l": "Sunitinib-resistant KIT mutants do not bind sunitinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76317", "l": "L-aspartate(out) + L-methionine(in) => L-aspartate(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165179", "l": "Formation of TSC1:TSC2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47528", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isocholate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35497", "l": "4-aminobenzoate + L-glutamate => H2O + N-(4-aminobenzoyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72610", "l": "(E)-sinapoyl-AMP + CoA <=> (E)-sinapoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373720", "l": "FADK1 interaction with DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017491", "l": "RHOJ GEFs activate RHOJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68699", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695964", "l": "ABHD14B hydrolyses PNPB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928619", "l": "PAK1 binds RAC1:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30644", "l": "phosphate + S-methyl-5'-thioinosine => hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20228", "l": "(E)-caffeate + S-adenosyl-L-methionine <=> (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196964", "l": "RFK:Mg2+ phosphorylates RIB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.381333653086259", "identifiers": [{"i": "GO:0005272", "l": "sodium channel activity", "d": ["Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202216", "l": "Phosphorylation of SLP-76 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69367", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA <=> CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52499", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76942", "l": "2-methylpropan-1-amine + H2O + NADP(+) <=> 2-methylpropanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132122", "l": "Activation of C1r within the C1complement complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654510", "l": "FGFRL1 binds SPRED1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28287", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63900", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141098", "l": "tRNA (cytidine(34)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32162", "l": "AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682026", "l": "MRN bound to shortened telomeres activates ATM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750942", "l": "USP14 deubiquitinates NLRC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69068", "l": "RFC dissociates after sliding clamp formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0019103", "l": "pyrimidine nucleotide binding", "d": ["Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73329", "l": "cimicifugate J + CoA => (2R,3S)-piscidate + (E)-sinapoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005246", "l": "calcium channel regulator activity", "d": ["Modulates the activity of a calcium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19122", "l": "an S-substituted glutathione(in) + ATP + H2O => ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28081", "l": "2-hydroxyethylphosphonate + NAD(+) <=> H(+) + NADH + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36246", "l": "(E)-anol + acetate + NADP(+) <=> (E)-coumaryl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73232", "l": "2,4,6-trichlorophenol + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48066", "l": "a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => a ganglioside GD1b (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75022", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate <=> 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080045", "l": "quercetin 3'-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48305", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947535", "l": "Cyclisation of GTP to precursor Z (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080070", "l": "8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65868", "l": "Delta(1)-dihydrotestosterone + H2O = 1,17beta-dihydroxyandrostan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14947", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912368", "l": "SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50605", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42634", "l": "5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514831", "l": "Fibrillin-1 degradation by MMP14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71087", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21880", "l": "2 H(+) + O2 + oxalate = 2 CO2 + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.4", "l": "\"oxalate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610722", "l": "CK1 phosphorylates p-GLI3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51875", "l": "dimethylallyl diphosphate + umbelliferone <=> diphosphate + osthenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51539", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50647", "l": "2-(3-methylsulfanyl)propylmalate <=> 3-(3-methylsulfanyl)propylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53035", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56976", "l": "4-methylphenol + H2O + 2 oxidized [azurin] = 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16514", "l": "(S)-lactate + O2 => acetate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47045", "l": "3-dehydrocarnitine + acetyl-CoA => acetoacetate + N,N,N-trimethylglycyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68018", "l": "(2E,6E,10E)-geranylgeraniol + phosphate => (2E,6E,10E)-geranylgeranyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47428", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) = 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12844", "l": "pyridoxamine + pyruvate <=> L-alanine + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007625", "l": "RBBP8 gene expression is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60032", "l": "8-oxo-GTP + H2O = 8-oxo-GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129362", "l": "Fibrillin microfibril assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21141", "l": "ATP + inosine => ADP + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202325", "l": "Recruitment of Gads to LAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097261", "l": "eoxin C4 synthase activity", "d": ["Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4."], "t": []}, {"i": "REACT:R-HSA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933533", "l": "Dimerization of p-IRF7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26056", "l": "GTP + H(+) + valienol 1-phosphate => diphosphate + GDP-valienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37659", "l": "anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate", "d": [], "t": []}, {"i": "EC:2.3.1.232", "l": "\"methanol O-anthraniloyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75862", "l": "Fall Back to Closed Pre-initiation Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140656", "l": "endodeoxyribonuclease activator activity", "d": ["Binds to and increases the activity of an endodeoxyribonuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51482", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18268", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) <=> 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835189", "l": "NCK1 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183052", "l": "CBL binds to GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817575", "l": "ERO1B oxidizes P4HB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47174", "l": "5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35086", "l": "diacetylchitobiose-6'-phosphate + H2O <=> acetate + N'-monoacetylchitobiose-6'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0031763", "l": "galanin receptor binding", "d": ["Binding to a galanin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674140", "l": "PAQR3 binds inactive RAFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35130", "l": "L-alanyl-D-glutamate(out) <=> L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15313", "l": "ethanolamine = acetaldehyde + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.7", "l": "\"ethanolamine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58903", "l": "1-carboxybiuret + H2O <=> NH4(+) + urea-1,3-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68991", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57260", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35142", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + demethoxycurcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102504", "l": "luteolinidin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose = luteolinidin 5-O-glucoside + UDP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18802", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate => (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.929404459305097", "identifiers": [{"i": "GO:0003677", "l": "DNA binding", "d": ["Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928576", "l": "RHOA:GTP binds ROCK, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67499", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O <=> 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26412", "l": "(R)-lactate + N-acetyl-D-glucosamine 6-phosphate => H2O + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15239", "l": "2 Fe(II)-[cytochrome c2] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c2] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38599", "l": "NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": [], "t": []}, {"i": "EC:2.4.99.20", "l": "\"2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61837", "l": "ergosterol + UDP-alpha-D-glucose => ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65507", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O <=> 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134800", "l": "STING dimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0004332", "l": "fructose-bisphosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047274", "l": "galactinol-sucrose galactosyltransferase activity", "d": ["Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74688", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332356", "l": "CAMK2 binds MAP3K7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69132", "l": "cadaverine + H2O + O2 = 5-aminopentanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49551", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] <=> H(+) + L-arginyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0043120", "l": "tumor necrosis factor binding", "d": ["Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28995", "l": "H(+)(out) + L-threonine(in) = H(+)(in) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42097", "l": "ATP + carbamoyl phosphate + H2O + tobramycin => AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54437", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66004", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}, {"i": "EC:2.1.1.377", "l": "\"[methyl-Co(III) glycine betaine-specific corrinoid protein]--coenzyme M methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55693", "l": "an inositol-1-phosphoceramide + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681987", "l": "LC3 is cleaved by ATG4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37035", "l": "H2O + L-2-aminopentanoate + NAD(+) = 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209903", "l": "Noradrenaline is converted to adrenaline (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29322", "l": "H2O + sn-glycero-3-phosphoethanolamine <=> ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54180", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.330", "l": "\"beta-D-glucosyl crocetin beta-1,6-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592371", "l": "Initial activation of proMMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63175", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA <=> (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75758", "l": "(10E)-octadecenoate + H2O <=> 10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48549", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O => [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034257", "l": "nicotinamide riboside transmembrane transporter activity", "d": ["Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other."], "t": []}, {"i": "RHEA:33163", "l": "beta-nicotinamide D-riboside(in) = beta-nicotinamide D-riboside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34736", "l": "a fatty acyl-CoA + sphinganine => an N-acylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33807", "l": "(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44219", "l": "12-hydroxyoctadecanoate + ATP + CoA <=> 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45466", "l": "(5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24830", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33596", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70409", "l": "(2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine => [(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65154", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-naringenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201515", "l": "Active ALK recruits PI3K (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673757", "l": "Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35974", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate <=> diphosphate + fumitremorgin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698932", "l": "Assembly of HCMV Procapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39677", "l": "3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA => (9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62903", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9703895", "l": "CASR binds CASR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66786", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167415", "l": "G-protein alpha subunit is inactivated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13051", "l": "D-fructuronate => D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16464", "l": "ATP + H2O + urate(in) <=> ADP + H(+) + phosphate + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15628", "l": "Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71242", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH <=> 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047551", "l": "2-oxoaldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67049", "l": "AH2 + chermesin D + O2 => A + asnovolin I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42935", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10656", "l": "guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.2", "l": "\"guanidinoacetate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.72", "l": "\"acetylxylan esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23964", "l": "(E)-coniferaldehyde + H2O + NADP(+) = (E)-ferulate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.57", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35008", "l": "D-fucose(in) => D-fucose(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58281", "l": "4 ATP => cyclic tetraadenylate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428123", "l": "KDSR reduces 3-ketosphingoid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71561", "l": "5-aminomethyl-dUMP in DNA + AH2 + glyoxylate => 5-N(alpha)-glycyl-dTMP in DNA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59490", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944232", "l": "Association of procollagen type XII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046099", "l": "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209973", "l": "Tyrosine is diiodinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0097507", "l": "hypoxanthine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58906", "l": "C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696822", "l": "AKR1B15 reduces EST17b to E1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23439", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156678", "l": "Activation of Cdc25C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004873", "l": "asialoglycoprotein receptor activity", "d": ["Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190260", "l": "FGFR2b binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12003", "l": "formate + NADP(+) <=> CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693061", "l": "STAMBP binds STAM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062193", "l": "D-ribose pyranase activity", "d": ["Catalysis of the reaction: beta-D-ribopyranose = beta-D-ribofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66590", "l": "a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 26S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202703", "l": "CD47 binds SIRP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030944", "l": "DDEL sequence binding", "d": ["Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74221", "l": "L-serine + tRNA(Thr) => H2O + L-seryl-tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.8", "l": "\"protein-disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798749", "l": "Exocytosis of specific granule lumen proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57733", "l": "A + all-trans-7,8-dihydroretinol => AH2 + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24662", "l": "H2O + N(omega)-hydroxy-L-arginine + NADP(+) => H(+) + L-arginine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730862", "l": "Autophosphorylation of LYN kinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53268", "l": "L-ribulose = L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332236", "l": "CBL neddylates TGFBR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005427", "l": "proton-dependent oligopeptide secondary active transmembrane transporter activity", "d": ["Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29412", "l": "glycolate(in) + H(+)(in) => glycolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169398", "l": "ISGylation of host protein filamin B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034598", "l": "phosphothreonine lyase activity", "d": ["Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483089", "l": "PE is converted to PS by PTDSS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54151", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene <=> 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9010872", "l": "SLIT2 binds Dystroglycan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52469", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507870", "l": "Aquaporins passively transport water out of cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165680", "l": "Formation of active mTORC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004329", "l": "formate-tetrahydrofolate ligase activity", "d": ["Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35804", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32629", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379974", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028724", "l": "AMOT proteins bind YAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47008", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72103", "l": "Formation of pre-mRNPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.200", "l": "\"tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11700", "l": "H(+) + NADPH + O2 + progesterone = H2O + NADP(+) + testosterone acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25005", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51030", "l": "7-chloroindole-3-pyruvate imine dimer + 2 H2O => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45755", "l": "(3E)-decenoyl-CoA <=> (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211206", "l": "Translocation of DFF to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160931", "l": "Disassembly of tight junctions (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804100", "l": "HMGB1 binds LPS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.132", "l": "\"chitosanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37834", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57258", "l": "GTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22583", "l": "(S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15774", "l": "ATP + dihydroxyacetone => ADP + dihydroxyacetone phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047667", "l": "AMP-thymidine kinase activity", "d": ["Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15474", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose => flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55833", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66636", "l": "(2E,6E)-farnesyl diphosphate + H2O = (-)-alpha-acorenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71984", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174438", "l": "Formation of the Flap Intermediate on the C-strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018819", "l": "lactoyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59997", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54904", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH = (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57683", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45974", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+) => 3-oxochol-4-en-22-oate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57577", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54000", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56520", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": [], "t": []}, {"i": "EC:1.3.98.6", "l": "\"AdoMet-dependent heme synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36382", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH <=> 4alpha-methylzymosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368588", "l": "DVL binds CCDC88C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59242", "l": "L-homoarginine + L-ornithine => L-arginine + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.96", "l": "\"lactocepin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25941", "l": "8-chloroquinoline + A + H2O => 8-chloroquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45326", "l": "H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine => H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690461", "l": "FKBP1A binds tacrolimus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25817", "l": "H2O + norspermine + O2 => 3-aminopropanal + H2O2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63743", "l": "2-phenylacetaldehyde + H(+) + NADH <=> 2-phenylethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840949", "l": "ARSA removes sulfate from SM3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30617", "l": "2 AH2 + all-trans-zeta-carotene => 15-cis-phytoene + 2 A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67266", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56003", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43962", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014652", "l": "Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23720", "l": "ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.3", "l": "\"propionyl-CoA carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.-.-", "l": "\"Acting on halogen in donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12768", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate <=> acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45151", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O <=> 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45480", "l": "gamma-hexachlorocyclohexane = (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42892", "l": "5'-deoxyadenosine + H(+) + H2O = 5'-deoxyinosine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.41", "l": "\"5'-deoxyadenosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42624", "l": "(Z)-3-ureidoacrylate + H(+) + H2O = (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75542", "l": "(2E)-decenoate + ATP + holo-[ACP] <=> (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48205", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53469", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17761", "l": "an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.91", "l": "\"aryl-alcohol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74351", "l": "2 (S)-lactate(in) + prostaglandin E3(out) = 2 (S)-lactate(out) + prostaglandin E3(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42916", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624953", "l": "ARL13B binds INPP5E (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57186", "l": "S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783681", "l": "LIF binds LIFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60087", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982792", "l": "Growth hormone receptor binds JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805059", "l": "CK2:FACT phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53314", "l": "16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177926", "l": "Dephosphorylation of PAG by SHP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62973", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10092", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.34", "l": "\"deoxynucleotide 3'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37081", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51824", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686345", "l": "SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53195", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55653", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51122", "l": "(8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30242", "l": "n a quinone + n H(+) + n hydrogen sulfide <=> n a quinol + n sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64314", "l": "dihydrogeodin + 2 FAD + H(+) + 4 H2O => 2 chloride + 2 FADH2 + 2 O2 + sulochrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75862", "l": "Fall Back to Closed Pre-initiation Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62047", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76354", "l": "oxaloacetate(in) + sulfate(out) <=> oxaloacetate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811508", "l": "ING2-bound EP300 acetylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18636", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine <=> 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201787", "l": "PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10977", "l": "H(+) + NADH + O2 + quinolin-2-ol => 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982778", "l": "Growth hormone binds the growth hormone receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036221", "l": "UTP diphosphatase activity", "d": ["Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35645", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2R)-2-hydroxycarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73396", "l": "L-aspartate(in) + sulfate(out) => L-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73563", "l": "dGDP(out) + UTP(in) = dGDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65325", "l": "acetyl-CoA + chrodrimanin A => chrodrimanin B + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57035", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O <=> CO2 + formate + methylamine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209891", "l": "Dopamine is oxidised to noradrenaline (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61804", "l": "ATP + H(+) + L-alanine = diphosphate + L-alanyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32117", "l": "CO2 + succinate + TRIBOA beta-D-glucoside => 2-oxoglutarate + DIBOA beta-D-glucoside + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71124", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA => AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602454", "l": "proMMP9 binds TIMP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70918", "l": "guanosine(in) + H(+)(in) <=> guanosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24032", "l": "sucrose = 6-O-alpha-D-glucopyranosyl-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12466", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP => myo-inositol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63091", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56535", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate <=> N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19865", "l": "4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III", "d": [], "t": []}, {"i": "EC:4.1.1.37", "l": "\"uroporphyrinogen decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47180", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27602", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749197", "l": "ORC1 binds to H4K20me2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55761", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid => an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39174", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75492", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) => 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062147", "l": "L-lysine 4-chlorinase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + chloride + H+ + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate."], "t": []}, {"i": "RHEA:59884", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004731", "l": "purine-nucleoside phosphorylase activity", "d": ["Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182988", "l": "Sprouty lures CBL away from EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791083", "l": "Expression of Sec12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57688", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide = cob(II)inamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76142", "l": "D-gluconate(in) <=> D-gluconate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11704", "l": "2 H(+) + N-(carboxyaminomethyl)urea = CO2 + N-(aminomethyl)urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052674", "l": "ent-pimara-9(11),15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754129", "l": "CDK6 inhibitors bind CDK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18986", "l": "chorismate => isochorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0031753", "l": "endothelial differentiation G protein-coupled receptor binding", "d": ["Binding to an endothelial differentiation G protein-coupled receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74546", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (E,E,E)-alpha-springene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35173", "l": "H(+)(in) + novobiocin(out) => H(+)(out) + novobiocin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52314", "l": "11-dehydro-thromboxane B2 + H(+) + NADH => NAD(+) + thromboxane B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045152", "l": "antisigma factor binding", "d": ["Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38930", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43646", "l": "3-oxohexadecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27385", "l": "H2O + maleamate = maleate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.107", "l": "\"maleamate amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21480", "l": "2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": [], "t": []}, {"i": "EC:1.3.99.8", "l": "\"2-furoyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17494", "l": "A + glycerol => AH2 + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61972", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26245", "l": "geranylgeranyl diphosphate = diphosphate + fusicocca-2,10(14)-diene", "d": [], "t": []}, {"i": "EC:4.2.3.43", "l": "\"fusicocca-2,10(14)-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617927", "l": "FOXO4 binds ATXN3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60927", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983394", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050547", "l": "vanillin synthase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879222", "l": "MDP:NLRP1 binds ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39943", "l": "a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444572", "l": "Zinc is an agonist of GPR39 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112392", "l": "Resumption of elongation after recovery from pausing (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693347", "l": "HTR1A binds 5HT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809680", "l": "MTMR12 binds MTM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33854", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) <=> GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29941", "l": "H(+)(out) + phosphate(out) => H(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850997", "l": "TRIM27 binds PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40868", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) => (2E,9E)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47708", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) = ADP-alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24369", "l": "L-ornithine => L-proline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35489", "l": "2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59654", "l": "D-xylotetraonate + H(+) => D-xylotetraono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72672", "l": "The 60S subunit joins the translation initiation complex  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56249", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50236", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033988", "l": "bile-acid 7alpha-dehydratase activity", "d": ["Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23134", "l": "7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite => 3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16350", "l": "AH2 + chlorate => A + chlorite + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16527", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+) => 2-dehydro-3-deoxy-D-galactonate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-874087", "l": "SGT1 binds HSP90 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69939", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070740", "l": "tubulin-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69148", "l": "H2O + O2 + spermine = H2O2 + NH4(+) + spermine monoaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660980", "l": "p-S276-RELA binds RELB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31252", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O => (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20964", "l": "2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32192", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53849", "l": "NAD(+) + taurocholate => 7-oxo-taurodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62027", "l": "campesteryl 3-beta-D-glucoside + H2O <=> campesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369115", "l": "SHP2 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39593", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40956", "l": "(R)-5-phosphomevalonate + ATP => ADP + CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53754", "l": "a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.-.-", "l": "\"Other isomerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28184", "l": "(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62607", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983158", "l": "Trimming of peptides in ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30512", "l": "2-demethylmenaquinone-8 + H(+) + NADPH => 2-demethylmenaquinol-8 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705961", "l": "nsp15 cleaves viral poly(U)-RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49118", "l": "deoxyviolaceinate + H2O + NADP(+) => H(+) + NADPH + O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13570", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51202", "l": "H2O + N-retinylidene-N-retinylphosphatidylethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.94", "l": "\"ethylmalonyl-CoA decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66793", "l": "N-methyl-D-dopa + O2 => (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13076", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65801", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O => a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24323", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68240", "l": "L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009916", "l": "alternative oxidase activity", "d": ["Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70857", "l": "L-glutamine(in) + L-serine(out) + Na(+)(in) => L-glutamine(out) + L-serine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75372", "l": "guanosine(in) => guanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879459", "l": "F-actin capping protein is a heterodimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16982", "l": "3-oxoadipate + NAD(+) => H(+) + maleylacetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62700", "l": "H2O + naphtopyrone YWA1 = acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174446", "l": "Removal of remaining Flap from the C-strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37663", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.312", "l": "\"protein O-mannose beta-1,4-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14844", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635850", "l": "GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15814", "l": "1H-imidazole + acetyl-CoA => CoA + N-acetylimidazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682544", "l": "nsp14 binds nsp10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.44", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12599", "l": "CoA + H(+) + N-acetylphosphinothricin => acetyl-CoA + phosphinothricin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917841", "l": "Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27564", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66309", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22923", "l": "L-glutamine + scyllo-inosose <=> 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.1", "l": "\"D-aspartate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190258", "l": "FGFR2c binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754974", "l": "ADK phosphorylates RBV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12722", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-methyl-5'-thioadenosine + spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13499", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+) => 5-dehydro-2-deoxy-D-gluconate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396370", "l": "VTN binds collagens II, III and V (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42967", "l": "uridine(54/55) in tRNA <=> pseudouridine(54/55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48522", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18164", "l": "acetyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40781", "l": "L-2-aminopentanoate + NH4(+) => 2-aminopentanenitrile + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50971", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O <=> inosine(37) in tRNA(Ala) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663265", "l": "NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169192", "l": "PTP1B dephosphorylates GHR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204364", "l": "ROBO1 binds SLIT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677050", "l": "Formation of the GCN5-ATAC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032775", "l": "YAP1 binds TEAD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005237", "l": "inhibitory extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67037", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76588", "l": "(6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + 2-oxoglutarate + AH2 + H(+) + O2 => (2S)-5,5-dimethylpiperidine-2-carboxylate + A + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77641", "l": "adenosine 5'-phosphosulfate + phosphate => 3'-phosphoadenylyl sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39011", "l": "a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77256", "l": "beta-D-glucosylceramide(in) => beta-D-glucosylceramide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45215", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) <=> CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.102", "l": "\"C-terminal processing peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788628", "l": "p-Y-STATs dissociate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047711", "l": "blasticidin-S deaminase activity", "d": ["Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707505", "l": "Hemes bind to CLEC1B dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24814", "l": "2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21035", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate <=> acceptor beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203130", "l": "OLR1 binds to oxidized LDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59578", "l": "beta-alanine + N(pros)-methyl-L-histidine => anserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32648", "l": "erythromycin C + S-adenosyl-L-methionine => erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047005", "l": "16-alpha-hydroxysteroid dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73207", "l": "sulfate(out) + sulfite(in) = sulfate(in) + sulfite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.991992031210344", "identifiers": [{"i": "GO:0004743", "l": "pyruvate kinase activity", "d": ["Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75844", "l": "ergothioneine(out) + Na(+)(out) => ergothioneine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60964", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032136", "l": "adenine/cytosine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/C mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58776", "l": "NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3-carbaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002153", "l": "steroid receptor RNA activator RNA binding", "d": ["Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23627", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) <=> a uridine in tRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74790", "l": "L-histidyl-L-proline diketopiperazine(in) <=> L-histidyl-L-proline diketopiperazine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28677", "l": "beta-D-galactose => alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77451", "l": "hydrogen cyanide + piperonal = (2S)-2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46342", "l": "ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate => ATP + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37476", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76068", "l": "an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine => an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32710", "l": "(2E)-geranyl diphosphate <=> (2R,4S)-bornyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63364", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63880", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate = cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": [], "t": []}, {"i": "EC:1.8.2.7", "l": "\"thiocyanate desulfurase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211239", "l": "Association of DFF40 with chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16832", "l": "an aldehyde + H2O + O2 <=> a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72585", "l": "3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47513", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69133", "l": "cadaverine + H2O + O2 => 5-aminopentanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672978", "l": "RAF phosphorylates MAP2K dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12287", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41406", "l": "2-methyl-1-pyrroline + H(+) + NADPH => (R)-2-methylpyrrolidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42934", "l": "2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0043844", "l": "ADP-specific phosphofructokinase activity", "d": ["Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70382", "l": "3-oxosphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295599", "l": "SPRY2 translocates to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59835", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50708", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71382", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) <=> D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74358", "l": "a cytidine in mRNA + H(+) + H2O <=> a uridine in mRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.496617203483822", "identifiers": [{"i": "GO:0005543", "l": "phospholipid binding", "d": ["Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004019", "l": "adenylosuccinate synthase activity", "d": ["Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052670", "l": "geraniol kinase activity", "d": ["Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64913", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O => a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14443", "l": "CoA + H(+) + N(3)-acetylgentamycin C => acetyl-CoA + gentamicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688797", "l": "ATXN3 family cleave Ub chains (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25601", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51116", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.256", "l": "\"tRNA (guanine(6)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15202", "l": "6-hydroxymellein + S-adenosyl-L-methionine => 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71728", "l": "citrate(out) + fumarate(in) => citrate(in) + fumarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51527", "l": "(S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.42", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23481", "l": "2-methylene-3-methylsuccinate => dimethylmaleate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001968", "l": "fibronectin binding", "d": ["Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851888", "l": "MET binds SHC1-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36293", "l": "formaldehyde + H2O + NADP(+) + xanthine => 3-methylxanthine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086410", "l": "CDK1 phosphorylates BORA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68947", "l": "esculetin + S-adenosyl-L-methionine <=> H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16754", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 => 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928640", "l": "PAKs phosphorylate MLC (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47024", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71141", "l": "3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+) => acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904408", "l": "melatonin binding", "d": ["Binding to melatonin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14915", "l": "adenosine + dTMP => AMP + thymidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74908", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] => (2E)-butenoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849463", "l": "PTK6 phosphorylates SFPQ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863494", "l": "ASICs bind STOML3, (STOM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39689", "l": "(2E,11Z)-octadecadienoyl-CoA + H2O => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45840", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) = 3-oxodecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12085", "l": "D-mannitol + NAD(+) => D-fructose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297444", "l": "Binding of cAMP to HCN channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018815", "l": "3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity", "d": ["Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.25", "l": "\"gellan lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858428", "l": "FCAMR binds IgA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0017024", "l": "myosin I binding", "d": ["Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18330", "l": "(1S,3R,5S)-sabinol + NAD(+) => (1S,5S)-sabinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44384", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247514", "l": "SCARF1:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706315", "l": "Active FLT3 binds to SH2B3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71262", "l": "2 Na(+)(out) + phosphate(out) <=> 2 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31305", "l": "an oxidized flavin + 2 H(+) + NADH => a reduced flavin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419490", "l": "Binding of ATP to P2X receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661230", "l": "MT1A binds arsenic (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77246", "l": "H(+) + hnu + octadecanoate <=> CO2 + heptadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28868", "l": "H(+)(in) + lactose(in) => H(+)(out) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65087", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66333", "l": "L-aspartate(out) => L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58608", "l": "2 L-ascorbate + N-decanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77193", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.11", "l": "\"isomaltulose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033450", "l": "GUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27333", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 = 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.114", "l": "\"6-hydroxynicotinate 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018772", "l": "trioxoheptanoate hydrolase activity", "d": ["Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45102", "l": "mitomycin B + S-adenosyl-L-homocysteine => 6-demethylmitomycin B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50319", "l": "ethyl octadecanoate + H2O <=> ethanol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13771", "l": "dihydroxyacetone + H(+) + NADH => glycerol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52511", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873830", "l": "STARD7 transports PC from ER membrane to mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022625", "l": "MECP2 binds FOXG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662781", "l": "CD163 gene produces CD163 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13957", "l": "4 H2O + O2 + 4 sulfur = 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": [], "t": []}, {"i": "EC:1.13.11.55", "l": "\"sulfur oxygenase/reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682826", "l": "LGI1 binds ADAM11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46349", "l": "(2E)-octenoyl-CoA + H2O => 3-hydroxyoctanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58151", "l": "ethyl acetate + H2O <=> acetate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002401", "l": "Association of procollagen type XVIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793933", "l": "Expression of MESP2 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65367", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805035", "l": "TP53 binds STK11 and NUAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944240", "l": "Association of procollagen type III (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11926", "l": "a globoside Gb3Cer (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11068", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.107", "l": "\"protein-glucosylgalactosylhydroxylysine glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12679", "l": "A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin => AH2 + Latia luciferin + 2 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66562", "l": "5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+) => (R)-noradrenaline + L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218822", "l": "CRK binds BCAR1 and or PXN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18617", "l": "ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate", "d": [], "t": []}, {"i": "EC:4.1.1.49", "l": "\"phosphoenolpyruvate carboxykinase (ATP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592436", "l": "Initial activation of proMMP9 by MMPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62831", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0046623", "l": "sphingolipid floppase activity", "d": ["Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647631", "l": "GSDMD (1-275) binds PIPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199935", "l": "MSK1 activates CREB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75521", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O => FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70538", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796368", "l": "RIPK1 binds STUB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24491", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55886", "l": "[aequorin]--dioxetanone => [aequorin] + 3 Ca(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876789", "l": "CARNMT1 methylates CARN to Anserine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42343", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44650", "l": "a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071890", "l": "bicarbonate binding", "d": ["Binding to bicarbonate ions (CHO3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73236", "l": "2,6-dichlorobenzoquinone + H2O => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31633", "l": "phosphate + pseudaminate => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33617", "l": "AMP + diphosphate + octadecanoyl-CoA => ATP + CoA + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55256", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805981", "l": "HMGB1 release from cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.60", "l": "\"glucan 1,4-alpha-maltotetraohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62441", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) => 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0034481", "l": "chondroitin sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301237", "l": "KAT2 complexes acetylate histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72691", "l": "Formation of the 43S pre-initiation complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28777", "l": "H(+) + H2O + hnu + oxidized dinoflagellate luciferin => dinoflagellate luciferin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41502", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74637", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate => 2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950740", "l": "CANX dissociates from IL12A:EBI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11650", "l": "1,4-menthane-3,8-diol + H2O + NADP(+) => (-)-menthol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28108", "l": "H(+) + keto-D-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54971", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51785", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate => deoxyhumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57071", "l": "3-oxoisoapionate + ATP <=> 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374298", "l": "Opioid receptors bind opioid peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23196", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine = 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": [], "t": []}, {"i": "EC:6.3.2.26", "l": "\"N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15889", "l": "H2O + L-glutamine = L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658163", "l": "Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68276", "l": "butanoyl-CoA + L-seryl-[protein] = CoA + O-butanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625378", "l": "STK11 gene transcription is stimulated by FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0042294", "l": "URM1 transferase activity", "d": ["Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140613", "l": "P-type manganese transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate."], "t": []}, {"i": "RHEA:66820", "l": "ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.22", "l": "\"P-type Mn(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.5", "l": "\"ribonuclease P\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57857", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 => (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013006", "l": "RHOA:GTP translocates to the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106250", "l": "DNA-binding transcription repressor activity, RNA polymerase III-specific", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445088", "l": "CHL1 interacts with beta1 integrins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047729", "l": "carnitine decarboxylase activity", "d": ["Catalysis of the reaction: carnitine + H+ = 2-methylcholine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67263", "l": "(E)-hept-2-enal + H2O + NAD(+) <=> (E)-hept-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.991992031210344", "identifiers": [{"i": "GO:0016823", "l": "hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances", "d": ["Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48812", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874080", "l": "SRC phosphorylates PTK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71316", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) => chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71974", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) <=> 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.375", "l": "\"L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45100", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine = mitomycin B + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21428", "l": "(2R)-3-sulfolactate = H(+) + pyruvate + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.24", "l": "\"(2R)-sulfolactate sulfo-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37355", "l": "H2O + uridine 2'-phosphate = phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168136", "l": "Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732822", "l": "nsp3 binds to PLpro inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928657", "l": "MMP2,9 cleave EPHB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67463", "l": "(R)-malate + A <=> AH2 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72009", "l": "succinate(out) + urate(in) => succinate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59041", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.261", "l": "\"sn-glycerol-1-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73750", "l": "(R)-noradrenaline(in) + 2 H(+)(out) <=> (R)-noradrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47212", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54290", "l": "diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30075", "l": "CMP + H2O = cytosine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37989", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol => delta-tocopherol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27839", "l": "9H-carbazole + H(+) + NADH + O2 => 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64822", "l": "2-phenylacetate + NH4(+) => 2-phenylacetamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9633044", "l": "ESR binds STRN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166220", "l": "FA anion diffuses laterally to UCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471314", "l": "HNP1-3 bind CD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33987", "l": "(+)-copalyl diphosphate = diphosphate + neoabietadiene", "d": [], "t": []}, {"i": "EC:4.2.3.132", "l": "\"neoabietadiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52278", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705926", "l": "AR binds AR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853496", "l": "SCF:FBXL7 binds AURKA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.106", "l": "\"O-acetyl-ADP-ribose deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44288", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52672", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.124", "l": "\"[amino-group carrier protein]-gamma-(L-ornithyl)-L-glutamate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990450", "l": "linear polyubiquitin binding", "d": ["Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23635", "l": "D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627107", "l": "XIAP binds CASP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74330", "l": "O-propanoyl-(R)-carnitine(in) <=> O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40642", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61053", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617595", "l": "SGTA binds mislocalized membrane protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76055", "l": "norreticuline + S-adenosyl-L-methionine = H(+) + reticuline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13953", "l": "a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10239", "l": "trans-2-coumarate + UDP-alpha-D-glucose <=> H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54182", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADH => a long-chain fatty aldehyde + holo-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950782", "l": "p-STAT1 binds p-STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73588", "l": "CTP(out) + UMP(in) => CTP(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43663", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> ADP + H(+) + methylmalonyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047249", "l": "sarsapogenin 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12489", "l": "2-amino-2-deoxy-D-gluconate => 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68395", "l": "H2O + peracetic acid <=> acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30575", "l": "3 menaquinone-8 + protoporphyrinogen IX = 3 menaquinol-8 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29859", "l": "5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13733", "l": "an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56667", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40173", "l": "(2E)-dodecenoyl-CoA + H2O2 => dodecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44032", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061710", "l": "L-threonylcarbamoyladenylate synthase", "d": ["Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40136", "l": "(9Z)-tetradecenoyl-CoA + H2O => (9Z)-tetradecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51899", "l": "H2O + N(1)-acetylspermine <=> acetate + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015554", "l": "tartrate transmembrane transporter activity", "d": ["Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204364", "l": "ROBO1 binds SLIT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783670", "l": "CRLF1 binds CLCF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30598", "l": "4-hydroxyphenylacetate + FADH2 + O2 <=> 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446694", "l": "IRAK4 phosphorylates IRAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51275", "l": "(9Z)-octadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53722", "l": "ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate => ATP + N-acetyl-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769401", "l": "DKK and KRM bind LRP5/6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200406", "l": "CPT1A,B transfers PALM to CAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15215", "l": "CoA + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] => N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46878", "l": "[(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27281", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158399", "l": "kallikrein binds SERPING1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45781", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25743", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine = (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41145", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202724", "l": "P-selectin binds P-selectin ligand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42136", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851018", "l": "BTN2A1 binds DC-SIGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652137", "l": "Damaged dsDNA becomes damaged DNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018559", "l": "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71497", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004154", "l": "dihydropterin oxidase activity", "d": ["Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-378952", "l": "Thyrotropin is a heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47778", "l": "2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60357", "l": "H2O + N-octanoylanthranilate => anthranilate + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46965", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38557", "l": "a fatty acid + all-trans-retinol + H(+) => an all-trans-retinyl ester + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.345", "l": "\"D-2-hydroxyacid dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38829", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48378", "l": "a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53596", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390425", "l": "FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42559", "l": "uridine(2819) in 21S rRNA <=> pseudouridine(2819) in 21S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.855431920422888", "identifiers": [{"i": "GO:0003723", "l": "RNA binding", "d": ["Binding to an RNA molecule or a portion thereof."], "t": []}, {"i": "REACT:R-HSA-203922", "l": "Exportin-5 recognizes 3' overhang of pre-miRNA  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610722", "l": "CK1 phosphorylates p-GLI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686625", "l": "LAIR1 binds collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389352", "l": "Translocation of Vav1 to CD28 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626270", "l": "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68221", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol => (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140761", "l": "sequestered tissue factor -> tissue factor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51056", "l": "A + androst-4-ene-3,17-dione = AH2 + androsta-1,4-diene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114284", "l": "Release of Cytochrome c from mitochondria (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684282", "l": "nsp9 forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210430", "l": "Release of L-Glutamate at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61736", "l": "steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20113", "l": "beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.4.2.6", "l": "\"beta-phosphoglucomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59348", "l": "D-maltobiono-1,5-lactone + H2O = D-maltobionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68863", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH <=> 7beta-25-dihydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22096", "l": "phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)", "d": [], "t": []}, {"i": "EC:2.7.7.8", "l": "\"polyribonucleotide nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804276", "l": "ATM phosphorylates TTC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76447", "l": "ATP + L-aspartate + L-methionine = ADP + H(+) + L-aspartyl-L-methionine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47237", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19634", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) => (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46692", "l": "4-hydroxybenzoate + ATP + H(+) = 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.42", "l": "\"guanosine-diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44770", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2 => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835992", "l": "VTRNA2-1 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57461", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40647", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72686", "l": "cholate(out) <=> cholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664306", "l": "LTC4 binds CyslTR1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63015", "l": "(2E,6E)-farnesyl diphosphate + orsellinate <=> diphosphate + ilicicolinate B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43770", "l": "N(5)-alkyl-L-glutaminyl-[protein] + NH4(+) => an alkylamine + L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63200", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH = (10bS,4aR)-oxomaritidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299318", "l": "Activation of TASK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64998", "l": "diphosphate + octanoyl-AMP => ATP + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72971", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015389", "l": "pyrimidine- and adenosine-specific:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in)."], "t": []}, {"i": "TCDB:2.A.41.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427337", "l": "MBD2 binds methylcytosine in chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10639", "l": "D-mannonate + NADP(+) <=> D-mannuronate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25313", "l": "glyoxylate + H2O2 => glycolate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75856", "l": "Abortive Initiation Before Second Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693783", "l": "NAALADases hydrolyse NAAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76802", "l": "(2S)-2-aminobutan-1-ol + H2O + NAD(+) <=> 1-hydroxy-2-butanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38113", "l": "H(+) + L-glyceraldehyde + NADPH => glycerol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40745", "l": "(20S)-ginsenoside C-K + 2 D-glucose => (20S)-ginsenoside Rd + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45522", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14028", "l": "H(+) + H2O + sepiapterin <=> NH4(+) + xanthopterin-B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51441", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21949", "l": "formamide + H2O => formate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55497", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785898", "l": "IL4R binds JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70329", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) + NADH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72233", "l": "chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in) => chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59368", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54960", "l": "ATP + CoA + dinor-OPDA = AMP + dinor-OPDA-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44610", "l": "2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51281", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51035", "l": "7-chloroindole-3-pyruvate imine dimer <=> dichlorochromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58004", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253343", "l": "WWOX binds ERBB4s80 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835121", "l": "Heparin binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34555", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0023023", "l": "MHC protein complex binding", "d": ["Binding to a major histocompatibility complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159733", "l": "Furin cleaves pro-factor X to factor X (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23146", "l": "2 H(+) + N-acetyl-D-glucosaminate + NADH => H2O + N-acetyl-alpha-D-glucosamine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15140", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-L-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050386", "l": "ureidosuccinase activity", "d": ["Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O + 2 H+ = L-aspartate + CO2 + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73286", "l": "H(+)(out) + L-isoleucine(in) <=> H(+)(in) + L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018675", "l": "(S)-limonene 6-monooxygenase activity", "d": ["Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044669", "l": "sodium:galactoside symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55137", "l": "ATP + D-alanine + H(+) => D-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034335", "l": "DNA negative supercoiling activity", "d": ["Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36320", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA => CoA + 2 NADP(+) + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047389", "l": "glycerophosphocholine phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448629", "l": "IL33 binds IL1RL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25194", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-methylcatechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69247", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70415", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O = (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008506", "l": "sucrose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047991", "l": "hydroxylamine oxidase activity", "d": ["Catalysis of the reaction: hydroxylamine + O2 = H2O + H+ + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61269", "l": "H2O + L-2-aminohexanoate + O2 => 2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102359", "l": "daphnetin 4-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin = UDP + 4-O- beta -D-glucosyl-daphnetin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69677", "l": "(S)-eriodictyol + beta-D-glucose => eriodictyol-7-O-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61772", "l": "rebaudioside E + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71057", "l": "L-cysteine(in) + L-methionine(out) => L-cysteine(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64367", "l": "prostaglandin G2 <=> (15S)-15-hydroperoxy-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026502", "l": "NTF3-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21000", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": [], "t": []}, {"i": "EC:1.97.1.2", "l": "\"pyrogallol hydroxytransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56145", "l": "a quinol + nitrate => a quinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67823", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018757", "l": "deisopropylhydroxyatrazine aminohydrolase activity", "d": ["Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15965", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16815", "l": "anthranilate + H(+) + L-alanine => H2O + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103072", "l": "straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity", "d": ["Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961632", "l": "POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433542", "l": "Phosphorylation and activation of VAV1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204863", "l": "Interaction of Tie2 with Ang2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57751", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH <=> C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15926", "l": "dihydrobunolol + NADP(+) => bunolol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40445", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+) => 6-deoxy-6-sulfo-D-fructose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33450", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44441", "l": "a 1,3-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.731030655927583", "identifiers": [{"i": "GO:0016893", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters."], "t": []}, {"i": "EC:3.1.30.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654404", "l": "Activated FGFR2 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13182", "l": "ATP + H2O + nitrate(out) => ADP + H(+) + nitrate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008684", "l": "TBK1 phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8957241", "l": "TP73 tetramer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77460", "l": "3-formylthiophene + hydrogen cyanide => (2S)-2-hydroxy-2-(thiophen-3-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836606", "l": "SPHK1 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25476", "l": "(2E,6E)-farnesyl diphosphate = alpha-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57196", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0031890", "l": "vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a vasoactive intestinal polypeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33421", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40977", "l": "2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170149", "l": "Translocation of active Cdc25C to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21338", "l": "4-pyridoxolactone + H(+) + NADH => NAD(+) + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66923", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate <=> (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620103", "l": "ALDH2 transforms GTN to NO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264435", "l": "Dissociation of the COP1-p53 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36911", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651685", "l": "Defective SLC34A1 does not cotransport Pi, 3Na+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71929", "l": "2 Na(+)(in) + tauroursodeoxycholate(in) => 2 Na(+)(out) + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24042", "l": "H(+) + NADP(+) + 2 reduced [cytochrome P450] => NADPH + 2 oxidized [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047273", "l": "galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983194", "l": "Kinesin-1 is a heterotetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748991", "l": "XDH oxidises 6MP to 6TU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032841", "l": "Activated NTRK2 binds CDK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.915726484813547", "identifiers": [{"i": "GO:0016799", "l": "hydrolase activity, hydrolyzing N-glycosyl compounds", "d": ["Catalysis of the hydrolysis of any N-glycosyl bond."], "t": []}, {"i": "EC:3.2.2.-", "l": "\"Hydrolyzing N-glycosyl compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692764", "l": "MAPK6 binds CCND3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75563", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] = cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629918", "l": "NEIL1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40145", "l": "(9Z,12Z)-octadecadienoate + CoA + H(+) => (9Z,12Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53595", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O <=> 1-tetradecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12742", "l": "ADP + H(+) + H2O => IDP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031801", "l": "type 4 metabotropic glutamate receptor binding", "d": ["Binding to a type 4 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707856", "l": "PGRMC2:Hemes dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11132", "l": "chlorophyllide a + NADP(+) = H(+) + NADPH + protochlorophyllide a", "d": [], "t": []}, {"i": "EC:1.3.1.33", "l": "\"protochlorophyllide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36426", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660663", "l": "Caspase-8 cleaves IL1B precursor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052879", "l": "9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity", "d": ["Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29420", "l": "H(+)(out) + Na(+)(in) => H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48077", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71319", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) = chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030780", "l": "12-hydroxydihydrochelirubine 12-O-methyltransferase activity", "d": ["Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57432", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] = 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66329", "l": "taurine(out) => taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30964", "l": "7,9,9'-tri-cis-neurosporene + a quinone => 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74214", "l": "H2O + L-threonyl-tRNA(Lys) <=> L-threonine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49068", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174967", "l": "NAT2 acetylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379387", "l": "COMT transfers Met to DA to form 3MT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12018", "l": "(-)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38782", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64698", "l": "benzaldehyde + H(+) + NADH => benzyl alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592371", "l": "Initial activation of proMMP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167601", "l": "Degradation of CD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45440", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052814", "l": "medium-chain-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34255", "l": "sporulenol = (R)-tetraprenyl-beta-curcumene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.137", "l": "\"sporulenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199298", "l": "AKT phosphorylates CREB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685608", "l": "CLEC2B binds KLRF1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16637", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.16", "l": "\"chitin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14609", "l": "D-sorbitol + NADP(+) = H(+) + keto-L-sorbose + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.289", "l": "\"sorbose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9667965", "l": "ANKLE2 binds PP2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043295", "l": "glutathione binding", "d": ["Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336443", "l": "LIN7, CASK and APBA1 bind (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76740", "l": "dodecane + O2 + reduced [NADPH--hemoprotein reductase] => 5-dodecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008721", "l": "D-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: D-serine = pyruvate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53111", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62042", "l": "N-octanoylsphing-4-enine + phosphate => H2O + N-(octanoyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36250", "l": "(E)-anol + S-adenosyl-L-methionine <=> (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60239", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64097", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53557", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63595", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46032", "l": "H2O2 + tetradecanoate = (2S)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48133", "l": "(2E,6E)-farnesyl phosphate + H2O => (2E,6E)-farnesol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418091", "l": "F2R binds ARRB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43812", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11428", "l": "beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351455", "l": "Phosphorylation of NBS1 by ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71443", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) = 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004866", "l": "endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an endopeptidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14159", "l": "diphosphate + phosphate => H2O + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39091", "l": "(2E)-decenedioyl-CoA + H2O = (3S)-hydroxydecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52087", "l": "13-octadecanoyloxy-octadecanoate + H2O <=> 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67733", "l": "uridylyl-uridylyl-ribonucleotide-RNA => a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.1", "l": "\"Physarum polycephalum ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062131", "l": "3-butenylglucosinolate 2-hydroxylase activity", "d": ["Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23490", "l": "hydroquinone + NADP(+) => 1,4-benzoquinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798044", "l": "BTG2 binds CCR4-NOT complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398040", "l": "Gbeta:gamma activation of PLC beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707856", "l": "PGRMC2:Hemes dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005356", "l": "glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76888", "l": "5-hydroxypentan-2-amine + H2O + NAD(+) => 5-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40482", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11269", "l": "D-cysteine + H2O => H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019841", "l": "retinol binding", "d": ["Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49521", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50013", "l": "H(+) + NADPH + O2 + tert-butanol => 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52034", "l": "(+)-7-isojasmonate + L-isoleucine => H2O + L-isoleucine-(+)-7-isojasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190258", "l": "FGFR2c binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865454", "l": "CBFB binds RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30314", "l": "7-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22213", "l": "(2R,3R)-tartrate => (2R,3S)-tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54936", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH = decanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.101", "l": "\"mannan endo-1,6-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420883", "l": "Opsins act as GEFs for G alpha-t (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50209", "l": "cortisol + NAD(+) => cortisone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.330956682939657", "identifiers": [{"i": "GO:0097367", "l": "carbohydrate derivative binding", "d": ["Binding to a carbohydrate derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52770", "l": "2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate => 2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18600", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] <=> NADH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25610", "l": "beta-D-allofuranose => beta-D-allopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64981", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210784", "l": "HNF1B-dependent synthesis of HNF6 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67912", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42904", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.188", "l": "\"23S rRNA (guanine(748)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615348", "l": "AGT(34-41) binds to AGTR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042881", "l": "D-galactonate transmembrane transporter activity", "d": ["Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796617", "l": "MIB2 binds CFLAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696670", "l": "CHD1L is recruited to GG-NER site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44101", "l": "H2O + NAD(+) + octanal => 2 H(+) + NADH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380949", "l": "AMPK is dephosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29625", "l": "alpha-maltohexaose + beta-D-glucose => alpha-maltopentaose + beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35813", "l": "(-)-medicarpin + H2O => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62127", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51590", "l": "5-pyridoxolactone + H(+) + NADH => isopyridoxal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44484", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72018", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine <=> 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833031", "l": "Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46143", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34378", "l": "4-guanidinobutanamide + H2O <=> 4-guanidinobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62875", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 <=> H2O + NADP(+) + semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45874", "l": "4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA => 15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42818", "l": "cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43391", "l": "1D-myo-inositol 3,4-bisphosphate + H2O <=> 1D-myo-inositol 3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73712", "l": "ATP(in) + UTP(out) => ATP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399939", "l": "Autophosphorylation of PAK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050216", "l": "propanediol-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13271", "l": "an N-acylsphing-4-enine + D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33109", "l": "diphosphate + gamma-muurolene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657786", "l": "NR1H2,3 binds the APOD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25424", "l": "diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52994", "l": "[deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001852", "l": "complement component iC3b binding", "d": ["Binding to a iC3b product of the complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839073", "l": "HTRA2 binds NDUFA13 (GRIM-19) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71511", "l": "phylloquinone(out) = phylloquinone(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22829", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419049", "l": "ROCK activation by RHO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165680", "l": "Formation of active mTORC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444433", "l": "Cho transports from the extracellular space to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18417", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.9", "l": "\"lactosylceramide alpha-2,3-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59718", "l": "D-maltopentaonate + H(+) => D-maltopentaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69883", "l": "L-ascorbate(out) + 2 Na(+)(out) = L-ascorbate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611277", "l": "P2RY12 binds P2RY12 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015441", "l": "ABC-type beta-glucan transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696357", "l": "LAIR2 binds collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55366", "l": "all-trans-nonaprenyl diphosphate + 6 diphosphate => (2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77471", "l": "hydrogen cyanide + pentan-2-one = (2S)-2-hydroxy-2-methylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44991", "l": "(R)-carnitine + 2-methylpropanoyl-CoA <=> CoA + O-isobutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74723", "l": "isorhamnetin + S-adenosyl-L-methionine = 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30872", "l": "2-deoxy-D-ribose + ATP => 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450488", "l": "BRF1 Complex recruits RNA degradation activities (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219536", "l": "AKT1 E17K mutant binds PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43321", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19073", "l": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": [], "t": []}, {"i": "EC:2.7.11.10", "l": "\"IkappaB kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052581", "l": "(-)-isopiperitenone reductase activity", "d": ["Catalysis of the reaction: (6R)-isoperitenone + H+ + NADPH = (2R,5R)-isopulegone + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14265", "l": "(S)-4-amino-5-oxopentanoate = 5-aminolevulinate", "d": [], "t": []}, {"i": "EC:5.4.3.8", "l": "\"glutamate-1-semialdehyde 2,1-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433578", "l": "phytoceramide + H2O => stearate + phytosphingosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647980", "l": "mature RAS proteins translocate to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.2", "l": "\"7-hydroxymethyl chlorophyll a reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450348", "l": "Activated human JNKs migrate to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27705", "l": "aldehydo-D-galacturonate <=> keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0015174", "l": "basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38427", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54591", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA <=> H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60108", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.20", "l": "\"S-sulfosulfanyl-L-cysteine sulfohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953430", "l": "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62981", "l": "(9Z)-hexadecenamide + H2O => (9Z)-hexadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13715", "l": "a ubiquinol + fumarate => a ubiquinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033897", "l": "ribonuclease T2 activity", "d": ["Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842656", "l": "ALK binds ALKAL ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013108", "l": "GDIs block activation of RHOC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48725", "l": "aurachin B + H(+) + H2O => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877879", "l": "RUNX1 and FOXP3 bind the RSPO3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.245308234813891", "identifiers": [{"i": "GO:0005227", "l": "calcium-activated cation channel activity", "d": ["Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient."], "t": []}, {"i": "REACT:R-HSA-9717383", "l": "TRPM4 transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10911", "l": "3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66677", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11787", "l": "H2O + L-aspartate + NADP(+) <=> H(+) + NADPH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45899", "l": "an N-acyl-sphingoid base + CDP-ethanolamine <=> an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432956", "l": "BP230 is recruited to the hemidesmosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218822", "l": "CRK binds BCAR1 and or PXN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683792", "l": "p-T68-CHEK2 autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74621", "l": "CMP(out) + UMP(in) => CMP(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29435", "l": "enterobactin(in) + H(+)(out) = enterobactin(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68203", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA <=> 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56266", "l": "CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52396", "l": "4-O-phospho-D-threonate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.408", "l": "\"4-phospho-D-threonate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658430", "l": "NF1 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61387", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49730", "l": "CO2 + 2 H2O + NADP(+) + violacein => 2 H(+) + NADPH + 2 O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928604", "l": "SFKs phosphorylate VAV2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829164", "l": "F subunits form trimers at plasma membrane rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689000", "l": "AADAC deacetylates PHEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10598", "l": "ADP + H(+) + O-phospho-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69856", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) => a uridine in mRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35504", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45450", "l": "dodecanoate + sphinganine => H2O + N-(dodecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35775", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose = 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34656", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191763", "l": "snRNP:Snurportin complex formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36399", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) = H(+) + NADPH + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627104", "l": "XIAP binds CASP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0044620", "l": "ACP phosphopantetheine attachment site binding", "d": ["Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76250", "l": "ATP + ergothioneine(out) + H2O <=> ADP + ergothioneine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636296", "l": "Mce3E binds MAPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14276", "l": "A + H2O + spermidine <=> 4-aminobutanal + AH2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030911", "l": "TPR domain binding", "d": ["Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201622", "l": "Caspase-mediated cleavage of gelsolin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008932", "l": "lytic endotransglycosylase activity", "d": ["Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends."], "t": []}, {"i": "EC:4.2.2.n2", "l": "\"peptidoglycan lytic endotransglycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33137", "l": "malonate(out) + Na(+)(out) => malonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001616", "l": "growth hormone secretagogue receptor activity", "d": ["Combining with ghrelin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70184", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57242", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GMP => glyoxal + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22779", "l": "2 H(+) + H2O2 + 2 Mn(2+) <=> 2 H2O + 2 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391913", "l": "FPR2 binds FPR2 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68205", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA => 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71838", "l": "estrone 3-sulfate(out) <=> estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203977", "l": "SAR1 Activation And Membrane Binding (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70110", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide <=> H(+) + penilactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189069", "l": "sucrose + H2O => glucose + fructose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46640", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42163", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37358", "l": "H2O + uridine 2'-phosphate <=> phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001067", "l": "pullulan binding", "d": ["Binding to pullulan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047242", "l": "hydroxyanthraquinone glucosyltransferase activity", "d": ["Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55972", "l": "acetyl-CoA + ethanol = CoA + ethyl acetate", "d": [], "t": []}, {"i": "EC:2.3.1.268", "l": "\"ethanol O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617179", "l": "PRKACA phosphorylates TNNI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252001", "l": "ATP1B4 binds SNW1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034850", "l": "isooctane monooxygenase activity", "d": ["Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371527", "l": "HSF1 trimer translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.61", "l": "\"diadenosine hexaphosphate hydrolase (ATP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022809", "l": "mobile ion carrier activity", "d": ["Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30846", "l": "H2O + N-formylmaleamate <=> formate + H(+) + maleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22330", "l": "diphosphate + thiamine phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37785", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46213", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine => 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25659", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] => (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29394", "l": "GTP + H2O <=> diphosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67976", "l": "all-trans-neurosporene = beta-zeacarotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55508", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.71", "l": "\"cucurbitadienol 11-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650473", "l": "SERPING1 is secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45849", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) => 3-oxododecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23454", "l": "ADP + dAMP + H(+) => 2'-deoxyadenosine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44558", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-hexaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49874", "l": "(+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (+)-dehydrodiconiferyl acid ketone + a quinone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19178", "l": "L-lysine => (3S)-3,6-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42382", "l": "2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+) => 2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36350", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine <=> 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52356", "l": "3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193700", "l": "p75NTR ICD signals to NF-kB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102358", "l": "daphnetin-8-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 7,8-dihydroxycoumarin = S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxycoumarin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757688", "l": "SERPINA6 binds PREDN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681987", "l": "LC3 is cleaved by ATG4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.18", "l": "\"GDP-mannose 3,5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103100", "l": "UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate = H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23440", "l": "4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H(+)", "d": [], "t": []}, {"i": "EC:3.8.1.6", "l": "\"4-chlorobenzoate dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13750", "l": "a ribonucleoside 5'-triphosphate + AMP => a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15245", "l": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211960", "l": "CYP2U1 19-hydroxylates ARA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693125", "l": "RHOF binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614591", "l": "Excess cysteine yields lanthionine and H2S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373747", "l": "Phosphorylation of nephrin by FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42883", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine <=> H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21496", "l": "dimethylallyl diphosphate + H2O = diphosphate + prenol", "d": [], "t": []}, {"i": "EC:3.1.7.1", "l": "\"prenyl-diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50645", "l": "2-(3-methylsulfanyl)propylmalate => 3-(3-methylsulfanyl)propylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19879", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76125", "l": "a dicarboxylate(out) + prostaglandin E2(in) => a dicarboxylate(in) + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21774", "l": "NH4(+) + uridine(6666) in apoB mRNA => cytidine(6666) in apoB mRNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961874", "l": "DHFR gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770132", "l": "Formation of the Spliceosomal Pre-B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.157", "l": "\"iota-carrageenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25285", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene <=> (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63846", "l": "2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + cumene hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169402", "l": "ISGylation of E2 conjugating enzymes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004506", "l": "squalene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606839", "l": "ARSC hydrolyzes steroid sulfates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21068", "l": "A + H2O + nitrite = AH2 + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25902", "l": "beta-D-fructose 6-phosphate => D-arabino-hex-3-ulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0036469", "l": "L-tryptophan decarboxylase activity", "d": ["Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445079", "l": "Phosphorylation of L1 by ERK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607744", "l": "MALT1 binds BCL10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18932", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA <=> 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295516", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159773", "l": "Furin cleaves pro-protein S to protein S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43808", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57943", "l": "Fe-coproporphyrin III + H(+) + H2O2 <=> CO2 + 2 H2O + harderoheme III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036033", "l": "mediator complex binding", "d": ["Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953336", "l": "Expression of EXTL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77584", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol => 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0036002", "l": "pre-mRNA binding", "d": ["Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71915", "l": "2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) + tauronorcholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017105", "l": "acyl-CoA delta11-(Z)-desaturase activity", "d": ["Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11Z)-delta-11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187828", "l": "Translocation of p21 to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21089", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 => a flavonol + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166538", "l": "The bound receptor dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134946", "l": "DDX41 ubiquitination by TRIM21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26489", "l": "H(+) + O-phospho-L-serine + sulfite <=> L-cysteate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47191", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol <=> hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69572", "l": "dIMP + inosine = 2'-deoxyinosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052738", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound."], "t": []}, {"i": "EC:1.2.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50513", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009703", "l": "nitrate reductase (NADH) activity", "d": ["Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445699", "l": "ATP Hydrolysis By Myosin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53985", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149519", "l": "MMACHC decyanates CNCbl (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73920", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) => H2O + norlichexanthone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379464", "l": "COMT transfers Met to DOPAC to form HVA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76314", "l": "L-aspartate(in) + L-glutamine(out) <=> L-aspartate(out) + L-glutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878056", "l": "RUNX1:CBFB binds EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47764", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404135", "l": "RBP4 binds atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16603", "l": "fumarate + NH4(+) => L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482775", "l": "Release of (inferred) platelet cytosolic components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35600", "l": "NADP(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449855", "l": "IL10 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44360", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.32", "l": "\"(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74593", "l": "5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784189", "l": "JAKs bind LIFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22067", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol <=> ergosterol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202291", "l": "Activation of Lck (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917693", "l": "ESCRT Disassembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46429", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69741", "l": "3-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794444", "l": "ALB binds Cipro (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454916", "l": "The ABCC family mediates organic anion transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23212", "l": "H2O + N-acetyl-beta-alanine = acetate + beta-alanine", "d": [], "t": []}, {"i": "EC:3.5.1.21", "l": "\"N-acetyl-beta-alanine deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210872", "l": "Trans-phosphorylation of Tie2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76599", "l": "(9Z,12Z)-octadecadienoate + H2O = (12Z)-10-hydroxyoctadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35170", "l": "minocycline(in) <=> minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75039", "l": "acetyl-CoA(in) = acetyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36431", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70951", "l": "D-serine + H2O + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31169", "l": "3-oxotetradecanoyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008574", "l": "plus-end-directed microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72095", "l": "Internal Methylation of mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41860", "l": "(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16425", "l": "formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.46", "l": "\"formaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19260", "l": "a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32588", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54696", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.50", "l": "\"4-hydroxybenzoate adenylyltransferase FadD22\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603784", "l": "PEX19:class I PMP binds PEX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61819", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose <=> 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102546", "l": "mannosylglycerate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate = alpha-D-mannose + D-glycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70541", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296309", "l": "HCAR3 binds HCAR3 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73823", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17094", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20330", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] => ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43759", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35428", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54375", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(2S,3R,9R)-pristinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022852", "l": "glycine-gated chloride ion channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74041", "l": "D-alanine(in) + L-alanine(out) => D-alanine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76320", "l": "L-aspartate(in) + L-leucine(out) => L-aspartate(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45221", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58630", "l": "FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.23", "l": "\"2-hydroxypropyl-CoM lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033284", "l": "NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77095", "l": "5-S-cysteinyldopa + L-dopaquinone = 5-S-cysteinyldopaquinone + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.245308234813891", "identifiers": [{"i": "GO:0016782", "l": "transferase activity, transferring sulphur-containing groups", "d": ["Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.8.-.-", "l": "\"Transferring sulfur-containing groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821366", "l": "AKAP8L binds MLL2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13844", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) <=> Fe(III)2-[transferrin] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730858", "l": "Autophosphorylation of BTK/ITK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070335", "l": "aspartate binding", "d": ["Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20033", "l": "isopenicillin N = penicillin N", "d": [], "t": []}, {"i": "EC:5.1.1.17", "l": "\"isopenicillin-N epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23511", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> (7R)-7-aminocephalosporanate + glutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25243", "l": "(S)-ureidoglycolate + NH4(+) => (S)-2-ureidoglycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010356", "l": "homogentisate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22603", "l": "H2O + N-acetyl-9-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50890", "l": "an N-acyl-sphingoid base + phosphate => an N-acylsphingoid base 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33070", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O <=> (4R)-hydroxysphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033417", "l": "CUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0097153", "l": "cysteine-type endopeptidase activity involved in apoptotic process", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process."], "t": []}, {"i": "REACT:R-HSA-6800797", "l": "The PIDDosome activates CASP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937022", "l": "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51981", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12949", "l": "D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.67", "l": "\"D-fuconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12146", "l": "cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-rutinoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849102", "l": "SRMS phosphorylates PTK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27582", "l": "(S)-2-hydroxymethylglutarate = 2-methyleneglutarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466831", "l": "A2PE hydrolyses to A2E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35432", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50602", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] => acetyl-CoA + N-terminal L-seryl-[histone H2A]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13931", "l": "putrescine + urea => agmatine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102963", "l": "(S)-corytuberine synthase activity", "d": ["Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 = (S)-corytuberine + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76131", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866269", "l": "ARRB bind GPCRs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20890", "l": "3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033990", "l": "ectoine synthase activity", "d": ["Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635854", "l": "GLI2,3 are degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221061", "l": "TDG excises 5-carboxylcytosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005412", "l": "glucose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63028", "l": "(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942302", "l": "MMP13 cleaves OPTC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070007", "l": "glutamic-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620828", "l": "FOXO1,FOXO3,(FOXO4) binds CCNG2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73335", "l": "ATP + beta-alanine + tryptamine = AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53719", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP <=> phosphate + UDP-N-acetyl-alpha-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706315", "l": "Active FLT3 binds to SH2B3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17134", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] => ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46591", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40716", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA => 1-hexadecanoylglycerone 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30955", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": [], "t": []}, {"i": "EC:1.3.5.6", "l": "\"9,9'-di-cis-zeta-carotene desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67142", "l": "H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034513", "l": "box H/ACA snoRNA binding", "d": ["Binding to a box H/ACA small nucleolar RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110218", "l": "Cleavage of uracil by TDG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44148", "l": "L-lysine = D-beta-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75730", "l": "(10E,12Z)-octadecadienoate + H2O <=> (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48235", "l": "acetyl-CoA + L-glutamate 5-semialdehyde <=> CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69392", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12304", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018739", "l": "4-hydroxybenzoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9621179", "l": "Cinaciguat binds sGC:NO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672011", "l": "p-AMPK:AMP binds the ULK complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74447", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004638", "l": "phosphoribosylaminoimidazole carboxylase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52784", "l": "2-sulfenohercynine + AH2 + H(+) = A + ergothioneine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12133", "l": "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51002", "l": "[fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine => [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68923", "l": "ATP + H(+) + NADPH + pentanoate <=> AMP + diphosphate + NADP(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679780", "l": "SIGMAR1 binds fluvoxamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0052820", "l": "DNA-1,N6-ethenoadenine N-glycosylase activity", "d": ["Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031777", "l": "type 1 melanin-concentrating hormone receptor binding", "d": ["Binding to a type 1 melanin-concentrating hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38838", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48967", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 <=> [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71047", "l": "glycine(in) + L-phenylalanine(out) = glycine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047637", "l": "phosphatidylglycerol alanyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.69", "l": "\"protein C (activated)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21367", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate <=> 2 6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047792", "l": "cyanohydrin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757686", "l": "SERPINA6 binds PREDL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102363", "l": "isoscopoletin-O-methyltransferase activity", "d": ["Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805811", "l": "Release of SEPT4 from mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14791", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59991", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) <=> cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13522", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733316", "l": "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654510", "l": "FGFRL1 binds SPRED1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33808", "l": "(E)-ferulate + H(+) => 2-methoxy-4-vinylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41157", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+) => 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32996", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707586", "l": "FeHM oxidises LDL,HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374667", "l": "DCC interaction with SIAH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20717", "l": "H(+) + H2O + S-adenosyl-L-homocysteine => NH4(+) + S-inosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21022", "l": "chorismate + phosphate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20141", "l": "an S-alkyl-L-cysteine S-oxide = 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64395", "l": "a dipeptide(out) + H(+)(out) <=> a dipeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38101", "l": "a ribonucleoside 5'-diphosphate + phytyl diphosphate => a ribonucleoside 5'-triphosphate + phytyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54961", "l": "ATP + CoA + dinor-OPDA => AMP + dinor-OPDA-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54719", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62405", "l": "(R)-2-hydroxyhexadecanoate + O2 => CO2 + H2O + pentadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75553", "l": "AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+) => 2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49113", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine => 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27685", "l": "ATP + dTDP <=> ADP + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75429", "l": "32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => eburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870461", "l": "RABGGTA and RABGGTB bind (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43451", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70368", "l": "3-oxosphinganine + octanoyl-CoA => CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848606", "l": "PTK6 phosphorylates PXN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186771", "l": "RNF111 binds SMAD7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265177", "l": "Exocyst complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32444", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25774", "l": "(2S,3S)-3-hydroxyasparagine + CO2 + succinate => 2-oxoglutarate + L-asparagine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173680", "l": "Activation of C5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15839", "l": "N-methyl-L-glutamate + NH4(+) => L-glutamate + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993802", "l": "HLCS biotinylates PC:Mn2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71888", "l": "GTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73705", "l": "UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out) => UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853320", "l": "FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40067", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69371", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) <=> 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47410", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29897", "l": "ADP + H(+) + L-glutamine(in) + phosphate => ATP + H2O + L-glutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653957", "l": "Rag dimer formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450474", "l": "MK2 phosphorylates BRF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.448477317467329", "identifiers": [{"i": "GO:0036094", "l": "small molecule binding", "d": ["Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033918", "l": "kappa-carrageenase activity", "d": ["Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047656", "l": "alpha,alpha-trehalose phosphorylase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804402", "l": "TP53 binds POU4F1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716160", "l": "SARS-CoV-2 M protein binds MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947535", "l": "Cyclisation of GTP to precursor Z (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14781", "l": "ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.14", "l": "\"6-carboxyhexanoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164507", "l": "CD4:gp120  binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465940", "l": "atRAL is reduced to atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046481", "l": "digalactosyldiacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54602", "l": "2-hydroxyoctanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76298", "l": "cob(I)alamin + S-adenosyl-L-methionine <=> methylcob(III)alamin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0015556", "l": "C4-dicarboxylate transmembrane transporter activity", "d": ["Enables the transfer of C4-dicarboxylate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676254", "l": "Formation of the MLL3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61496", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018694", "l": "p-cymene methyl hydroxylase activity", "d": ["Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33580", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20279", "l": "an N-acetoxyarylamine + CoA => acetyl-CoA + an N-hydroxyarylamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048000", "l": "isoflavone 3'-hydroxylase activity", "d": ["Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23427", "l": "alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54454", "l": "a uridine in tRNA + H(+) + NADH => a 5,6-dihydrouridine in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53067", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate <=> 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851890", "l": "MET phosphorylates SHC1-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74012", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40917", "l": "(9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204500", "l": "CyP60 chaperones Basigin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391942", "l": "IP receptor can bind prostacyclin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11628", "l": "a 2-oxocarboxylate + H(+) = an aldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990756", "l": "ubiquitin ligase-substrate adaptor activity", "d": ["The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28618", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 = 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49953", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55185", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 => 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445705", "l": "Release Of ADP From Myosin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54901", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH => hexadecanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863463", "l": "STON2 binds SYT proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210292", "l": "Interaction of DAP12 and TREM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77276", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA => 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46997", "l": "6-hydroxy-N-methylmyosmine + H2O => 6-hydroxypseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77612", "l": "Formation of dsRNA structure by looping  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130194", "l": "ABL phosphorylates WAVEs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853496", "l": "SCF:FBXL7 binds AURKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902417", "l": "(+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity", "d": ["Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40729", "l": "a 1-acylglycerone 3-phosphate + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658496", "l": "SIAH1:UBE2L6:Ubiquitin binds SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44203", "l": "12-methyloctadecanoate + ATP + CoA <=> 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165680", "l": "Formation of active mTORC1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77675", "l": "a globoside GalGb4Cer (d18:1(4E)) + H2O = an N-acylsphing-4-enine + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30635", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.267", "l": "\"dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140985", "l": "G protein-coupled chemorepellent receptor activity", "d": ["Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44104", "l": "decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428625", "l": "Vesicular inhibitory amino acid transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73913", "l": "ADP + H(+) + psilocybin => ATP + psilocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54579", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 <=> an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29692", "l": "alpha-maltotetraose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54862", "l": "(1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+) => (2E)-geranial + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27282", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.1.102", "l": "\"2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801209", "l": "TP53 binds the TRIAP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16891", "l": "6-acetamido-3-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-acetamido-3-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5333051", "l": "RPA1 binds HSF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211191", "l": "Association of DFF with alpha:beta importin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55343", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol <=> 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27371", "l": "acetaldehyde + acetyl-CoA + H(+) + NADH => acetoin + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22999", "l": "H2O2 + L-ascorbate <=> 2 H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14588", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29469", "l": "H(+)(in) + K(+)(out) => H(+)(out) + K(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37795", "l": "2 H(+) + 2 NADPH + O2 = 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36844", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75656", "l": "(9Z)-octadecenoate + O2 => (8R)-hydroperoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38942", "l": "dioscin + 2 H2O <=> diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48995", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 <=> 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47985", "l": "H2O + presqualene diphosphate => diphosphate + hydroxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17290", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17309", "l": "a phenyl acetate + H2O = a phenol + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.2", "l": "\"arylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353430", "l": "Binding of Pol eta to a DNA template containing a lesion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351913", "l": "Caspase-mediated cleavage of TJP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69276", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = but-3-enenitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55139", "l": "ATP + D-alanine + H(+) <=> D-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10644", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.57", "l": "\"2-pyrone-4,6-dicarboxylate lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73098", "l": "AMP(out) + CoA(in) <=> AMP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0061602", "l": "molybdenum cofactor cytidylyltransferase activity", "d": ["Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43165", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416562", "l": "p190RhoGAP binds Plexin-B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035560", "l": "pheophorbidase activity", "d": ["Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661726", "l": "An unknown reductase reduces D-UBGN to STBN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.-.-", "l": "\"Acting on NADH or NADPH\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805479", "l": "TP53RK phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37586", "l": "D-lysine + H2O + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23521", "l": "acetyl-CoA + propanoate => acetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082391", "l": "Trimerization of HSF1 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26162", "l": "thalianol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52740", "l": "glyphosate + H2O + O2 = aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24579", "l": "diphosphate + H2O <=> H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19222", "l": "2 formaldehyde + H2O => formate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58975", "l": "H2O + O2 + vanillin <=> H(+) + H2O2 + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622310", "l": "Activated NOD1 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036201", "l": "ent-isokaurene C2-hydroxylase activity", "d": ["Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018798", "l": "RHOV binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174444", "l": "Formation of C-strand Okazaki fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862300", "l": "LYZ binds bacterial peptidoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13337", "l": "D-glucurono-6,2-lactone + H2O = D-glucuronate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.19", "l": "\"uronolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40345", "l": "acetyl-CoA + tetradecanedioyl-CoA => 3-oxohexadecanedioyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49391", "l": "UDP-alpha-D-glucose + validoxylamine A <=> H(+) + UDP + validamycin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53982", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63079", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28099", "l": "ATP + GDP => AMP + guanosine 3',5'-bis(diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327746", "l": "FN1 aggregation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42161", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008084", "l": "imaginal disc growth factor receptor binding", "d": ["Binding to an imaginal disc growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23995", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851888", "l": "MET binds SHC1-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034936", "l": "4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19688", "l": "(E)-feruloyl-CoA + tyramine <=> CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004657", "l": "proline dehydrogenase activity", "d": ["Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59875", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.49", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070975", "l": "FHA domain binding", "d": ["Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033991", "l": "aldos-2-ulose dehydratase activity", "d": ["Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062152", "l": "mRNA (cytidine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}, {"i": "RHEA:61464", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75343", "l": "adenosine(in) = adenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202328", "l": "Translocation of PKC theta to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20509", "l": "ATP + viomycin = ADP + H(+) + O-phosphoviomycin", "d": [], "t": []}, {"i": "EC:2.7.1.103", "l": "\"viomycin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33911", "l": "an N-alkylglycine + H2O + O2 = an alkylamine + glyoxylate + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.20", "l": "\"N-alkylglycine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426163", "l": "SREBP1A,2 binds the CYP51A1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080139", "l": "borate efflux transmembrane transporter activity", "d": ["Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75773", "l": "(10S)-hydroxy-(12Z,15Z)-octadecadienoate => (9Z,12Z,15Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73878", "l": "(R)-adrenaline(out) <=> (R)-adrenaline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61502", "l": "delphinidin 3-O-beta-D-glucoside + UDP => delphinidin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20800", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10842", "l": "L-threonine + phosphate => H2O + O-phospho-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54270", "l": "(3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34777", "l": "a 3-oxosteroid + CO2 + NADH => a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371353", "l": "Soluble TNF-α binds TNFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54757", "l": "deamido-NAD(+) + hydrogencarbonate => AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51339", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.73", "l": "\"licheninase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106341", "l": "omega-hydroxyceramide transacylase activity", "d": ["Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine."], "t": []}, {"i": "RHEA:55264", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004576", "l": "oligosaccharyl transferase activity", "d": ["Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13704", "l": "acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32230", "l": "(6R)-NADPHX <=> (6S)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29266", "l": "L-leucine(in) + Na(+)(in) <=> L-leucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32386", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) <=> (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28361", "l": "FAD + H(+) + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212642", "l": "L-Glutamine transport into neurons (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21220", "l": "L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.29", "l": "\"stizolobate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.12", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.77", "l": "\"oleate 10S-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912355", "l": "Glycosylation of Pre-NOTCH by FRINGE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102027", "l": "S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine = menaquinol-8 + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66344", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56698", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102522", "l": "tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe = 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53068", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693012", "l": "TNFSF15 binds TNFRSF25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001567", "l": "cholesterol 25-hydroxylase activity", "d": ["Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62639", "l": "a hydroperoxide + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] <=> an alcohol + H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11138", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36876", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10935", "l": "ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71961", "l": "3 Na(+)(in) + oxaloacetate(in) => 3 Na(+)(out) + oxaloacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63741", "l": "2-phenylacetaldehyde + H(+) + NADH => 2-phenylethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17835", "l": "3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxyanthranilate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51428", "l": "acetyl-CoA + aminomethylphosphonate = 2-N-acetamidomethylphosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449574", "l": "SLC2A4 (GLUT4) vesicle fuses with the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050001", "l": "D-glutaminase activity", "d": ["Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60263", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19534", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine => CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27656", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 => 2-oxobutanoate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.21", "l": "\"maltose epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39883", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53397", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689649", "l": "BAP1 binds BRCA1:BARD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58853", "l": "(6E)-8-oxogeraniol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53254", "l": "5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60134", "l": "a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18687", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+) => H(+) + NADPH + O2 + pentachlorophenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58105", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63441", "l": "(2R)-3-phosphoglycerate + GTP + H(+) => 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419841", "l": "Light stimulates opsin receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44302", "l": "4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71655", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O = a thymidine in DNA + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77147", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24732", "l": "aniline + CO2 => anthranilate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23390", "l": "7''-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21244", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61807", "l": "ATP + H(+) + L-alanine <=> diphosphate + L-alanyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73733", "l": "(2S,3R,11S)-aszonalenin + diphosphate => (S)-benzodiazepinedione + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218836", "l": "PTK2beta binds alphaVbeta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416698", "l": "SEMA5A binds to PLXNB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18663", "l": "H(+) + L-ornithine + NADPH + pyruvate => H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607734", "l": "PKC-delta translocates to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29753", "l": "acetoacetate(out) => acetoacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954117", "l": "E2F6:TFDP1 binds EPC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64539", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202726", "l": "F11R dimerises (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32993", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33818", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate <=> 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21871", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12595", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29638", "l": "D-maltopentaose + H2O <=> alpha-D-glucose + D-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675473", "l": "SH2B binds JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16723", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35461", "l": "cholest-5-en-3-one + H(+) + NADH => cholesterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052788", "l": "d-4,5 unsaturated beta-glucuronyl hydrolase activity", "d": ["Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16208", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18448", "l": "H2O + IMP <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66034", "l": "alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33494", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75717", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate => CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211219", "l": "Translocation of caspase-3 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001607", "l": "neuromedin U receptor activity", "d": ["Combining with neuromedin U to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653886", "l": "B4GALT1 binds LALBA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77156", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,4,5-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140699", "l": "cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30426", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-delta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71578", "l": "5-phosphomethyl-dUMP in DNA + putrescine <=> 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694462", "l": "ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928627", "l": "EPHB phosphorylates TIAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75353", "l": "4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine => 2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852552", "l": "MST1R autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28150", "l": "acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44666", "l": "a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20703", "l": "ATP + lipid A disaccharide (E. coli) <=> ADP + H(+) + lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689111", "l": "PARK2 autoubiquitinates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33824", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH => NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32168", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine => aerobactin + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651773", "l": "LIG1 binds POLB at long-patch BER site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40824", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41543", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54578", "l": "an adenosine in tRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23129", "l": "4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53472", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42190", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 3beta-hydroxy-5alpha-androstan-17-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13946", "l": "(S)-mandelate => (R)-mandelate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5159250", "l": "ATF7IP binds SETDB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605056", "l": "Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047908", "l": "fusarinine-C ornithinesterase activity", "d": ["Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53500", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660753", "l": "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43056", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.239", "l": "\"10-deoxymethynolide syntase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034713", "l": "type I transforming growth factor beta receptor binding", "d": ["Binding to a type I transforming growth factor beta receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071618", "l": "lysophosphatidylethanolamine acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65883", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A <=> 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944247", "l": "Association of procollagen type VI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77693", "l": "a ganglioside Fuc-GD1b (d18:1(4E)) + GDP + H(+) => a ganglioside GD1b (d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.857794534555751", "identifiers": [{"i": "GO:0008757", "l": "S-adenosylmethionine-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001537", "l": "N-acetylgalactosamine 4-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22227", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA <=> 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803047", "l": "DCD peptide binds bacterial membrane phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53366", "l": "H(+) + NADH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31328", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol => bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685602", "l": "NCR3LG1 binds NCR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76974", "l": "1-(9Z-octadecenoyl)-2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O <=> (9Z)-octadecenoate + 2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804100", "l": "HMGB1 binds LPS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23737", "l": "5-hydroxyisourate + H2O => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848392", "l": "IL18BP binds IL18 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169406", "l": "ISGylation of host proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419644", "l": "Transphosphorylation of pLIMK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39695", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050210", "l": "prenyl-diphosphatase activity", "d": ["Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69380", "l": "2-hydroxy-4-methylpentanoate + O2 = 4-methyl-2-oxopentanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9680443", "l": "ROCK1,2 bind ROCKi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48251", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) <=> CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14996", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0018031", "l": "peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29954", "l": "H(+)(in) + uridine(in) <=> H(+)(out) + uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20303", "l": "AMP + diphosphate + L-arginyl-tRNA(Arg) => ATP + L-arginine + tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39941", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9761421", "l": "CDH11 associates with catenins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183126", "l": "Factor B binds to surface-associated C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46237", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015124", "l": "allantoate transmembrane transporter activity", "d": ["Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983427", "l": "Expression of peptide bound class I MHC on cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57025", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67588", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25645", "l": "(2R,5R)-isomenthone + NADP(+) = (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165162", "l": "Phosphorylation of TSC2 by PKB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357483", "l": "RAC1 binds PAK1-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43303", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322431", "l": "XIAP binds TLE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32093", "l": "dTDP + erythromycin D + H(+) => 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25555", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemar-13-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29797", "l": "ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in) => ATP(in) + H2O(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16074", "l": "2,2-dialkylglycine + H(+) + pyruvate => CO2 + dialkyl ketone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30891", "l": "O-acetyl-L-serine + thiosulfate = acetate + H(+) + S-sulfo-L-cysteine", "d": [], "t": []}, {"i": "EC:2.5.1.144", "l": "\"S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047171", "l": "glucarolactone O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53161", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine => an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443439", "l": "c-Src binds Raf1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40203", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55996", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15815", "l": "CoA + N-acetylimidazole => 1H-imidazole + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25094", "l": "ATP + dCMP = ADP + dCDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48858", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352059", "l": "SLC6A15-mediated amino acid uptake (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31071", "l": "(S)-2-methyl-3-oxopropanoate + L-alanine = (S)-3-amino-2-methylpropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55862", "l": "all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71631", "l": "phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33584", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688834", "l": "ATXN3 binds VCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14457", "l": "glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.12", "l": "\"3-propylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37817", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873923", "l": "STARD10 binds LPCAT1 and PC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71042", "l": "L-methionine(in) + L-phenylalanine(out) <=> L-methionine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77690", "l": "a ganglioside GD1a (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GalNAc-GD1a (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036190", "l": "indole-2-monooxygenase activity", "d": ["Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62253", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) => 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944227", "l": "Association of procollagen type XXII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196753", "l": "2xPPCS ligates PPanK with Cys (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804100", "l": "HMGB1 binds LPS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19733", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) = bacteriochlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10384", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = beta-cyclopiazonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050693", "l": "LBD domain binding", "d": ["Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51520", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186773", "l": "PDGF dimer binds two receptors simultaneously (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49491", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73307", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) = H(+)(out) + L-aspartate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17975", "l": "5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine => diphosphate + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12340", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045352", "l": "interleukin-1 type I receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to interleukin-1 type I receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63001", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O => (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679044", "l": "FKBP1A binds sirolimus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55860", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49331", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51766", "l": "4-prenylphlorisovalerophenone + diphosphate => dimethylallyl diphosphate + phlorisovalerophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22512", "l": "3 H(+) + precorrin-8X = hydrogenobyrinate", "d": [], "t": []}, {"i": "EC:5.4.99.61", "l": "\"precorrin-8X methylmutase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75972", "l": "NADP(+) + neomorphine => H(+) + NADPH + neomorphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66199", "l": "acetyl-CoA + tryptamine <=> CoA + H(+) + N-acetyltryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26287", "l": "Co-precorrin-6A + S-adenosyl-L-homocysteine => Co-precorrin-5B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19662", "l": "D-mannitol 1-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56979", "l": "4-methylphenol + H2O + 2 oxidized [azurin] <=> 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18060", "l": "O2 + Watasenia luciferin <=> CO2 + hnu + oxidized Watasenia luciferin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25998", "l": "H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + N(1)-acetylspermine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389348", "l": "Activation of Rac1 by pVav1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42957", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656215", "l": "RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49260", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] = D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.204", "l": "\"protein-N(pi)-phosphohistidine--D-galactose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36222", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46115", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54876", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693111", "l": "RHOF auto-activates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20526", "l": "ATP + ethylamine + L-glutamate => ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24536", "l": "L-tryptophan + O2 = N-formyl-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31543", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose = 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": [], "t": []}, {"i": "EC:2.4.1.276", "l": "\"zeaxanthin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099626", "l": "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "d": ["Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709842", "l": "MAVS binds TOMM70 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69478", "l": "CoA + H(+) + N(6)-acetyl-L-lysine => acetyl-CoA + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199298", "l": "AKT phosphorylates CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35252", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928597", "l": "EPH:EFN dimers tetramerise (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702508", "l": "FLT mutants bind type I TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246506", "l": "botC HC:LC binds GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53462", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate => 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030742", "l": "GTP-dependent protein binding", "d": ["Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45520", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": [], "t": []}, {"i": "EC:4.4.1.31", "l": "\"phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53902", "l": "ADP + H(+) + O-phospho-L-threonyl-[myosin light chain] => ATP + L-threonyl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034844", "l": "naphthyl-2-methyl-succinate CoA-transferase activity", "d": ["Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69253", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => 2-(thiiran-2-yl)acetonitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43904", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.10", "l": "\"chloride peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0032356", "l": "oxidized DNA binding", "d": ["Binding to a DNA region containing an oxidized residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24790", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50196", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835443", "l": "STAT1,STAT3 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097265", "l": "5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity", "d": ["Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+."], "t": []}, {"i": "REACT:R-HSA-2161776", "l": "5S-HETE is oxidised to 5-oxoETE by 5-HEDH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48061", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51888", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.404", "l": "\"tetrachlorobenzoquinone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24627", "l": "ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851109", "l": "NPM1-ALK- and STAT3-dependent TWIST gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.12", "l": "\"Xaa-Xaa-Pro tripeptidyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.998276081196508", "identifiers": [{"i": "GO:0016836", "l": "hydro-lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by elimination of water."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170120", "l": "Translocation of Cdc25B to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374662", "l": "Translocation of Ezrin to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851979", "l": "BTNL9 binds immune cell surfaces (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.101", "l": "\"xanthomonalisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164832", "l": "ATPase synthesizes ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421495", "l": "Synthesis of ALAS2 nascent polypeptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43743", "l": "ATP + CoA + hexanoate <=> AMP + diphosphate + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198669", "l": "p38MAPK phosphorylates MSK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74050", "l": "L-alanine(in) + L-valine(out) <=> L-alanine(out) + L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55590", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047214", "l": "cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102560", "l": "5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity", "d": ["Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = D-ribofuranose 2,5-bisphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11698", "l": "H(+) + S-adenosyl-L-homocysteine + staurosporine => 3'-demethylstaurosporine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32514", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754130", "l": "CDK4 inhibitors bind CDK4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110319", "l": "Elongation by POLH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51121", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 => (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0009041", "l": "UMP/dUMP kinase activity", "d": ["Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14584", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH <=> 2 L-ascorbate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55844", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769401", "l": "DKK and KRM bind LRP5/6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58620", "l": "N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351936", "l": "Caspase-mediated cleavage of claspin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18634", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine => 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11664", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.5", "l": "\"galactosyldiacylglycerol alpha-2,3-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050382", "l": "uracil-5-carboxylate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + uracil 5-carboxylate = CO2 + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38596", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48698", "l": "H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71866", "l": "taurodeoxycholate(out) <=> taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000285", "l": "1-phosphatidylinositol-3-phosphate 5-kinase activity", "d": ["Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45111", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840334", "l": "PSAP gets cleaved (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69595", "l": "CMP + inosine <=> cytidine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47143", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928625", "l": "PAKs autophosphorylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72961", "l": "(R)-3-hydroxybutanoate(in) + 2 Na(+)(in) => (R)-3-hydroxybutanoate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60260", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.354", "l": "\"[histone H3]-lysine(4) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65163", "l": "benzoyl-CoA + hexan-2-ol <=> CoA + hexan-2-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018607", "l": "1-indanone monooxygenase activity", "d": ["Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61583", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) <=> (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634934", "l": "CDK5R1 gene expression is stimulated by NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24530", "l": "H(+) + methylglyoxal + NADH => (R)-lactaldehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36559", "l": "A + cis-4-hydroxy-D-proline = 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46356", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14933", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76852", "l": "(S)-sec-butylamine + H2O + NAD(+) => butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433066", "l": "Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11676", "l": "D-ribose + H2O + NADP(+) = D-ribonate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.115", "l": "\"ribose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10269", "l": "2-dehydro-3-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.33", "l": "\"amylo-alpha-1,6-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199131", "l": "PVR binds CD226 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57466", "l": "1-O-[(E)-caffeoyl]-beta-D-glucose + UDP => (E)-caffeate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848250", "l": "ACBD6 binds LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16055", "l": "H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22597", "l": "cephalosporin C + H2O => acetate + deacetylcephalosporin C + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806957", "l": "MET receptor dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014456", "l": "GDIs block activation of RHOG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247839", "l": "Retromer associates with WLS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43095", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA <=> 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32368", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22494", "l": "formamide + L-glutamate => H2O + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177692", "l": "Activation of recruited TAK1 within the activated TLR3 complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38345", "l": "(20S)-ginsenoside Rg3 + D-glucose => (20S)-ginsenoside Rd + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102423", "l": "(+)-sesaminol 2-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose = (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60786", "l": "CO2 + gibberellin A25 + H(+) + succinate => 2-oxoglutarate + gibberellin A24 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211734", "l": "Ubiquitination of PAK-2p34 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76677", "l": "CoA + H(+) + N-acyl-1-deoxysphinganine => 1-deoxysphinganine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31287", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA = acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25238", "l": "ATP + CDP => ADP + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19566", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + sabinene hydrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52897", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin => 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67258", "l": "2 H(+) + NADH + propanoate => H2O + NAD(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373745", "l": "SDK1 homophillic interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14557", "l": "H2O + raucaffricine = D-glucose + vomilenine", "d": [], "t": []}, {"i": "EC:3.2.1.125", "l": "\"raucaffricine beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612514", "l": "p-S133 CREB and p-S103 SRF bind the EGR1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389463", "l": "Proteinase-activated receptors can bind thrombin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73901", "l": "ADP + gamma-L-glutamylcadaverine + H(+) + phosphate => ATP + cadaverine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42498", "l": "10-deacetyl-2-debenzoylbaccatin III => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15342", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide => ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25101", "l": "ATP + UDP <=> ADP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008139", "l": "nuclear localization sequence binding", "d": ["Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50821", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => H(+) + NADPH + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196773", "l": "COASY phosphorylates DP-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000310", "l": "AURKA phosphorylates PLK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13835", "l": "5-guanidino-2-oxopentanoate + L-alanine => L-arginine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24394", "l": "dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate => dTDP-L-dihydrostreptose + streptidine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70811", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28355", "l": "decanoyl-CoA + FAD + H(+) => (2E)-decenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63395", "l": "A + Fe(II)-heme o + H2O <=> AH2 + Fe(II)-heme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22978", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928641", "l": "PAK binds RAC and bPIX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36302", "l": "(E)-caffeate + ATP + CoA <=> (E)-caffeoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77074", "l": "(2E,6E)-farnesyl diphosphate <=> (1R,4R,5S)-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417908", "l": "P2RY1 binds ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24623", "l": "NAD(+) + octan-1-ol <=> H(+) + NADH + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.96", "l": "\"carboxynorspermidine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046659", "l": "digestive hormone activity", "d": ["The action characteristic of a hormone that takes part in the digestion process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47622", "l": "2-ethylhexanal + CO2 + H(+) + succinate + sulfate => 2-ethylhexyl sulfate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034874", "l": "thioacetamide S-oxide S-oxygenase activity", "d": ["Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36218", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31409", "l": "all-trans-4,4'-diapolycopene + FADH2 => all-trans-4,4'-diaponeurosporene + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76466", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A <=> 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37544", "l": "2-amino-5-chlorophenol + O2 => 2-amino-5-chloromuconate 6-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33161", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015173", "l": "aromatic amino acid transmembrane transporter activity", "d": ["Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40266", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801666", "l": "PLK2 phosphorylates CENPJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50500", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033427", "l": "CAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41325", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35076", "l": "doxorubicin(in) + H(+)(out) => doxorubicin(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76618", "l": "3-oxopropanoate + CoA + H2O + NAD(+) <=> acetyl-CoA + H(+) + hydrogencarbonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002935", "l": "tRNA (adenine(37)-C2)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine37 in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine37 in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28559", "l": "D-fructose 6-phosphate + H2O => D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28098", "l": "ATP + GDP = AMP + guanosine 3',5'-bis(diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46979", "l": "(S)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034347", "l": "type III interferon binding", "d": ["Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73764", "l": "2 ATP + L-alanine + L-tryptophan => 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000831", "l": "inositol hexakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033841", "l": "6G-fructosyltransferase activity", "d": ["Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948034", "l": "FGR binds LDL:LRP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18103", "l": "3-ethylcatechol + H(+) + NADH => cis-1,2-dihydro-3-ethylcatechol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39866", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41821", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72542", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381668", "l": "cAMP activates EPAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517705", "l": "p-S318,221-HuR binds mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33940", "l": "H(+) + L-arginine + NADH + O2 => H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186780", "l": "Degradation of Ub-SMAD7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404193", "l": "IGF1R phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928607", "l": "p-EPHs bind VAV2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592278", "l": "Autocatalytic activation of proMMP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023846", "l": "Estrogen-responsive CTSD expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19296", "l": "a monoacylglycerol + ATP <=> ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629679", "l": "PDE3A inhibitors bind PDE3A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67424", "l": "a glycerophospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163549", "l": "phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37044", "l": "ATP + H2O + L-alanyl-L-glutamate(out) => ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11288", "l": "dihydromacarpine + H(+) + O2 = H2O2 + macarpine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14701", "l": "2 CoA + NAD(+) = CoA-disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40353", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65117", "l": "2-oxoglutarate + aculene B + O2 => aculene A + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29670", "l": "H2O(in) <=> H2O(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50987", "l": "prostaglandin E2(out) <=> prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985201", "l": "ABCE1 binds RNASEL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56029", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35769", "l": "8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydrosterigmatocystin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15545", "l": "(3S)-citramalate = acetate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.22", "l": "\"citramalate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59479", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine <=> 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008513", "l": "secondary active organic cation transmembrane transporter activity", "d": ["Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."], "t": []}, {"i": "REACT:R-HSA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807872", "l": "Active ARF recruits coatomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27551", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.31", "l": "\"ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13688", "l": "lathosterol + NADP(+) <=> 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043838", "l": "phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity", "d": ["Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21278", "l": "D-xylulose + H(+) + NADPH => D-arabinitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.63", "l": "\"methylated-DNA--[protein]-cysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31710", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26414", "l": "a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.4.3.4", "l": "\"monoamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018838", "l": "mandelate racemase activity", "d": ["Catalysis of the reaction: (S)-mandelate = (R)-mandelate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14327", "l": "daphnin + H(+) + UDP => 7,8-dihydroxycoumarin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696465", "l": "USP45 deubiquitinates ERCC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39570", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69354", "l": "H2O + thiosulfinate => 2 (E)-prop-1-en-1-SO-peroxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16123", "l": "3-(carbamoylamino)propanoate + H(+) => 5,6-dihydrouracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661446", "l": "BMG, BDG translocates from ER lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189062", "l": "lactose + H2O => D-glucose + D-galactose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76593", "l": "N,N-dimethylglycine(in) + Na(+)(in) => N,N-dimethylglycine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938108", "l": "SERPINB13 binds cathepsin L (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64111", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837448", "l": "Formation of hRSV A dsRNA intermediate form (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202960", "l": "Caspase mediated cleavage of C-IAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28571", "l": "ATP + L-serine => diphosphate + L-seryl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32888", "l": "all-trans-beta-carotene + O2 => 2 all-trans-retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45103", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine <=> mitomycin B + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44183", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36503", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209924", "l": "Dopa is decarboxylated to dopamine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74771", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634850", "l": "NPAS4 binds ARNT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73945", "l": "FAS-mediated dimerization of procaspase-8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985594", "l": "MYO9B inactivates RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734713", "l": "ORC6 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034534", "l": "1-methylnaphthalene hydroxylase activity", "d": ["Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72398", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) <=> 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45775", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate <=> [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26399", "l": "2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => all-trans-zeaxanthin + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23819", "l": "2-oxoglutarate + putrescine <=> 4-aminobutanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14744", "l": "4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76187", "l": "an L-amino acid tripeptide(out) + 2 H(+)(out) = an L-amino acid tripeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43653", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627107", "l": "XIAP binds CASP7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48620", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77608", "l": "Binding of A1CF to stem-looped RNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662904", "l": "CD isomers transform to BT, BTCA, BZ, ODHBT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75871", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.385", "l": "\"[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215406", "l": "PRMT5 binds WDR77 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.138", "l": "\"coumarin 8-geranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11925", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19415", "l": "AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) => ATP + L-phenylalanine + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64776", "l": "3-sulfanylpentan-1-ol-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59746", "l": "CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein] => (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55110", "l": "(3R)-hydroxynonanoyl-[ACP] + NADP(+) => 3-oxononanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56626", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+) => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47289", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49564", "l": "D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.155", "l": "\"2-epi-valiolone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36746", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60464", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14869", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39242", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH <=> NADP(+) + triacontanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444661", "l": "HCAR2 binds HCAR2 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59853", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24783", "l": "C-13(2)-carboxypyropheophorbide a + H(+) <=> CO2 + pyropheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38806", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53331", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine <=> 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9619376", "l": "CAMK1 binds calmodulin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031782", "l": "type 4 melanocortin receptor binding", "d": ["Binding to a type 4 melanocortin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57796", "l": "4-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65199", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine <=> H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65904", "l": "3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106151", "l": "CNBH domain intrinsic ligand binding", "d": ["Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68004", "l": "AH2 + chloroethene = A + chloride + ethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74734", "l": "Re-integration of insulin receptor into plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28660", "l": "beta-lactose + H2O => beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473184", "l": "Follistatin (FST) binds Activin (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24277", "l": "acetate + diphosphate => acetyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50925", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351207", "l": "Spermine  => N-acetylated spermine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010341", "l": "gibberellin carboxyl-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11571", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP <=> 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373734", "l": "Nephrin interacts with Podocin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68889", "l": "2-methoxybenzoate + ATP + H(+) + NADPH => 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15347", "l": "AMP + diphosphate + H(+) + L-tyrosyl-L-arginine => ATP + L-arginine + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22031", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol <=> CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68290", "l": "CoA + O-heptanoyl-L-seryl-[protein] => heptanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782655", "l": "HDAC10 deacetylates histone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21934", "l": "L-homoserine lactone + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009558", "l": "IL34 dimer binds SDC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031724", "l": "CXCR5 chemokine receptor binding", "d": ["Binding to a CXCR5 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728664", "l": "GLP1R binds GLP1R agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49855", "l": "(3E)-octenoyl-CoA <=> (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16110", "l": "ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204871", "l": "Interaction of Tie2 and Grb2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36131", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.278", "l": "\"indole-3-acetate O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871265", "l": "YAP1 binds TEAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20633", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.2.30", "l": "\"L-ornithine N(alpha)-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17589", "l": "2,2'-iminodipropanoate + H2O + NAD(+) = H(+) + L-alanine + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.17", "l": "\"alanopine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32973", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42750", "l": "5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(967) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43806", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31991", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquithujene", "d": [], "t": []}, {"i": "EC:4.2.3.102", "l": "\"sesquithujene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43741", "l": "ATP + CoA + hexanoate => AMP + diphosphate + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736966", "l": "SMAD7 binds SERPINE1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445087", "l": "CHL1 interacts with HSP7C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64910", "l": "CMP + 2 H(+) + 2 phosphate => CTP + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781922", "l": "USP13 binds UFD1L:SKP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875523", "l": "MET binds TNS3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853745", "l": "RET binds GFRA1,GFRA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45254", "l": "tetradecanoate(in) => tetradecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46496", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23805", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate => N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50369", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 => 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15589", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.72", "l": "\"D-4-hydroxyphenylglycine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12839", "l": "ADP + H(+) + phosphocholine => ATP + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26201", "l": "ammeline + H(+) + H2O = ammelide + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15182", "l": "an acyl-CoA(out) + ATP + H2O => ADP + an acyl-CoA(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13913", "l": "L-threonine = D-threonine", "d": [], "t": []}, {"i": "EC:5.1.1.6", "l": "\"threonine racemase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647994", "l": "RAS proteins are depalmitoylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22595", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37097", "l": "3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37611", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58555", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16R)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43009", "l": "D-serine => 2-aminoprop-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247513", "l": "STAB1:ligand is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004805", "l": "trehalose-phosphatase activity", "d": ["Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13737", "l": "an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837149", "l": "TBRG4 (FASTKD4) binds mitochondrial rRNAs and mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41020", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56055", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50455", "l": "prostaglandin H3 <=> prostaglandin E3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45533", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52841", "l": "UDP-alpha-D-glucose + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10778", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.024411547311772", "identifiers": [{"i": "GO:0015149", "l": "hexose transmembrane transporter activity", "d": ["Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195378", "l": "Homodimerization of VEGF proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61884", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65864", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O = 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015123", "l": "acetate transmembrane transporter activity", "d": ["Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481009", "l": "Exocytosis of platelet dense granule content (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74464", "l": "(-)-4'-methoxycyclopenine => 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18526", "l": "3-methylbutanol + NADP(+) => 3-methylbutanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42580", "l": "ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64587", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) <=> 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70596", "l": "GOT2 dimer deaminates L-Asp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252133", "l": "ATP6AP1 binds V-ATPase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449978", "l": "IL7 binds IL7R:JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47022", "l": "[DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37550", "l": "D-glucose 6-phosphate + NAD(+) <=> 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35199", "l": "(S,S)-tartrate(out) = (S,S)-tartrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55840", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69075", "l": "H2O + O2 + serotonin <=> (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000286", "l": "alanine dehydrogenase activity", "d": ["Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51213", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019807", "l": "aspartoacylase activity", "d": ["Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718379", "l": "GNRHR binds chemical antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72286", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75160", "l": "NAD(+) + TTP => H(+) + NADP(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112396", "l": "Separation of elongating transcript from template (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032564", "l": "dATP binding", "d": ["Binding to dATP, deoxyadenosine triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23145", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) => 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59329", "l": "D-xylono-1,5-lactone + H2O => D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10600", "l": "prostaglandin H2 = prostaglandin D2", "d": [], "t": []}, {"i": "EC:5.3.99.2", "l": "\"prostaglandin-D synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19329", "l": "nuatigenin + UDP-alpha-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.192", "l": "\"nuatigenin 3beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578965", "l": "TNRC6A binds AGO2:miRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.-", "l": "\"Transferring other groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682967", "l": "WHSC1 binds DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682012", "l": "ATG5:ATG12 binds ATG16L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65462", "l": "CoA + hexyl acetate => acetyl-CoA + hexan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033250", "l": "penicillinase activity", "d": ["Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102942", "l": "3,5-dimethoxyphenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65777", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50269", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016362", "l": "activin receptor activity, type II", "d": ["Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor."], "t": []}, {"i": "REACT:R-HSA-201443", "l": "Type II receptor phosphorylates type I receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803719", "l": "TP53 binds ZNF385A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66905", "l": "A + cannabinerolate => AH2 + cannabichromenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54149", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36346", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 <=> 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43022", "l": "2-aminoprop-2-enoate + L-homocysteine => L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140850", "l": "histone H2B C-terminal K residue ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to a histone 2B at the conserved C-terminal lysine (K) residue. The last K residue is at position 119 in fission yeast, 123 in budding yeast, and 120 in mammals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604722", "l": "Activation of proMMP9 by proteases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45590", "l": "a long-chain fatty acyl-[ACP] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52568", "l": "epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060698", "l": "endoribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of endoribonuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54821", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68408", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) = 2-oxosuberate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25150", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde <=> H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14737", "l": "CTP = 3',5'-cyclic CMP + diphosphate", "d": [], "t": []}, {"i": "EC:4.6.1.6", "l": "\"cytidylate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24253", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10532", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": [], "t": []}, {"i": "EC:4.2.1.20", "l": "\"tryptophan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65269", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 => chrodrimanin F + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51014", "l": "a monoacylglycerol + H(+) + phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2464822", "l": "RDH12 reduces atRAL to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706399", "l": "RHOBTB3 hydrolyzes ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58697", "l": "NADPH + O2 + rifampicin => H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351948", "l": "Mitochondrial recruitment of Drp1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61908", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol = 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.22", "l": "\"NAD(+) diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37467", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37742", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53216", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56098", "l": "[protein]-C-terminal Gly-Gly-AMP + diphosphate => [protein]-C-terminal Gly-Gly + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75924", "l": "(S)-4-aminopentanoate + H2O + NAD(+) => 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177934", "l": "EGFR autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66334", "l": "L-aspartate(in) => L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26375", "l": "[thioredoxin]-dithiol + prostamide H2 => [thioredoxin]-disulfide + prostamide F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69391", "l": "(S)-2-ureidoglycine + carbamoyl phosphate <=> allantoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55017", "l": "H(+) + menthone + NADPH + O2 => 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848370", "l": "IL18 binds IL18R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38431", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36449", "l": "ADP + glycyl-L-proline(in) + H(+) + phosphate => ATP + glycyl-L-proline(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43676", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849900", "l": "SALMs1-3 bind each other in cis interactions (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65802", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine => a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31546", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose <=> 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12354", "l": "H2O2 + L-xylo-hex-3-ulonolactone => L-gulono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74751", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol = holo-[polyketide synthase] + prefumagillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44087", "l": "ATP + CoA + heptadecanoate <=> AMP + diphosphate + heptadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19837", "l": "D-sorbitol 6-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.140", "l": "\"sorbitol-6-phosphate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392530", "l": "p-S400-Cot phosphorylates NIK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047156", "l": "acetoin-ribose-5-phosphate transaldolase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690702", "l": "LYN phosphorylates CD22 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52407", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47818", "l": "9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13801", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite", "d": [], "t": []}, {"i": "EC:1.8.1.2", "l": "\"assimilatory sulfite reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62703", "l": "H2O + naphtopyrone YWA1 <=> acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051525", "l": "NFAT protein binding", "d": ["Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69867", "l": "a uridine in RNA + S-adenosyl-L-methionine = a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18097", "l": "pteridine-2,4,6,7-tetrol = H(+) + xanthine-8-carboxylate", "d": [], "t": []}, {"i": "EC:5.5.1.3", "l": "\"tetrahydroxypteridine cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38974", "l": "O2 + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004939", "l": "beta-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58623", "l": "N-decanoyl-(2S)-hydroxyglycine <=> decanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481010", "l": "Surface deployment of platelet dense granule membrane components (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11390", "l": "an 11-oxosteroid + H(+) + NADPH => an 11beta-hydroxysteroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73332", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA => cimicifugate E + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55878", "l": "apo-[aequorin]--coelenterazine => apo-[aequorin] + coelenterazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61521", "l": "AH2 + dopamine => 3-tyramine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24378", "l": "AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168960", "l": "Collagen type XVII ectodomain shedding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030761", "l": "8-hydroxyquercitin 8-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43955", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34870", "l": "ATP + CoA + thiophene-2-carboxylate <=> AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951644", "l": "Release of mature NEDD8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60954", "l": "(E)-sinapate + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferulate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75850", "l": "Addition of the third nucleotide on the nascent transcript (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:1990817", "l": "poly(A) RNA polymerase activity", "d": ["Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047212", "l": "2-coumarate O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67110", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371591", "l": "Trimerization of cytosolic HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44102", "l": "2 H(+) + NADH + octanoate => H2O + NAD(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37539", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734337", "l": "NKX2-5 binds the TBX5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59988", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) = cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35429", "l": "(E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24457", "l": "alpha-ribazole 5'-phosphate + H2O => alpha-ribazole + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0000175", "l": "3'-5'-RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0018488", "l": "aryl-aldehyde oxidase activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.124", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111879", "l": "PIP2 hydrolysis (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16813", "l": "H2O + L-kynurenine = anthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74133", "l": "H(+) + malvidin 3-O-beta-D-galactoside + UDP => malvidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216051", "l": "Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448744", "l": "IL20RA binds IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61498", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836585", "l": "SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982017", "l": "Active G alpha (q) binds RGS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57418", "l": "L-aspartyl-[protein] + NH4(+) => H2O + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77376", "l": "H(+) + heptadecanoate + hnu => CO2 + hexadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042014", "l": "interleukin-19 receptor activity", "d": ["Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114684", "l": "Phosphorylation of Syntaxin-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64781", "l": "S-benzyl-L-cysteine => 2-aminoprop-2-enoate + benzylthiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202969", "l": "Caspase mediated cleavage of beta-catenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984606", "l": "Kinesin-5 is a homotetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103096", "l": "CYP79F1 dihomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061711", "l": "N(6)-L-threonylcarbamoyladenine synthase activity", "d": ["Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106358", "l": "glycerol-1-phosphate dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH."], "t": []}, {"i": "RHEA:21416", "l": "NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43821", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182986", "l": "CBL-mediated ubiquitination of CIN85 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0097243", "l": "flavonoid binding", "d": ["Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44292", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731931", "l": "EDNRA binds selective ERAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62181", "l": "H2O + peregrinol diphosphate => diphosphate + viteagnusin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16033", "l": "2-oxoglutarate + gibberellin A44 + O2 = CO2 + gibberellin A19 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.12", "l": "\"gibberellin-44 dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62936", "l": "H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25948", "l": "a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.174", "l": "\"diacylglycerol kinase (CTP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41918", "l": "3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexadecanoyl-[ACP] + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25421", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O => 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16081", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O = (2R)-S-methyl-1-thioglycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.14", "l": "\"methylphosphothioglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51825", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22750", "l": "2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198508", "l": "MDH1 oxidizes MAL to OA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54533", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine => 2-oxoglutarate + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30311", "l": "7-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033798", "l": "thyroxine 5-deiodinase activity", "d": ["Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31657", "l": "5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine => 4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29406", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 <=> 3-demethylubiquinol-8 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54246", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730528", "l": "SARS-CoV-2 3a binds to STING (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17003", "l": "proclavaminate + urea => amidinoproclavaminate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56128", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin = AH2 + diphosphate + flavuxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52183", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033422", "l": "CCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70510", "l": "LDH tetramer oxidises LACT to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16266", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate => 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76797", "l": "H(+) + hydroxyacetone + NADH + NH4(+) => 2-aminopropan-1-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71098", "l": "2 Na(+)(out) + pregnenolone sulfate(out) <=> 2 Na(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12031", "l": "H2O + L-5-carboxymethylhydantoin <=> H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710263", "l": "GZMB cleaves GSDME (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199203", "l": "PANK1/3 phosphorylate PanK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28133", "l": "baicalin + H2O <=> baicalein + D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57183", "l": "L-lysyl-[protein] + methylglyoxal <=> N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111879", "l": "PIP2 hydrolysis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74697", "l": "(5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76969", "l": "a short-chain fatty acid + 2 H(+) + NADPH => a short-chain fatty aldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43834", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878056", "l": "RUNX1:CBFB binds EP300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65907", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62580", "l": "ATP + D-cystine(out) + H2O = ADP + D-cystine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42184", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19987", "l": "H(+) + NADH + S-formylglutathione => NAD(+) + S-(hydroxymethyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71043", "l": "L-alanine(in) + L-phenylalanine(out) = L-alanine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014456", "l": "GDIs block activation of RHOG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66114", "l": "(2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate => 2-oxobutanoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17439", "l": "(2E,4E)-2,4-dichloromuconate + H(+) => 2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46771", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67711", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13469", "l": "A + H2O + thymine = 5-methylbarbiturate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28925", "l": "H(+)(out) + L-phenylalanine(out) => H(+)(in) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428609", "l": "Type I Na+-coupled phosphate co-transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710263", "l": "GZMB cleaves GSDME (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73142", "l": "lithocholate(out) <=> lithocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40034", "l": "ent-copalyl diphosphate + H2O <=> diphosphate + ent-manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-982810", "l": "JAK2 phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001594", "l": "trace-amine receptor activity", "d": ["Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21411", "l": "H2O + L-phenylalanine + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55818", "l": "5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine => a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58165", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O => 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14668", "l": "guanine + H(+) + H2O <=> NH4(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70287", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696358", "l": "TREM,CD300 binds lipids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0044389", "l": "ubiquitin-like protein ligase binding", "d": ["Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33034", "l": "H(+) + keto-D-fructose + NADH <=> D-sorbitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077420", "l": "FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64473", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine => (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68914", "l": "DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67644", "l": "ATP + dZDP = ADP + dZTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665278", "l": "Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618328", "l": "ATAT acetylates microtubules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36252", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69625", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12431", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH <=> benzene-1,2,4-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19356", "l": "glycocholate + H2O <=> cholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25343", "l": "H2O + urea => carbamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28716", "l": "(R)-malate(in) + 2 H(+)(in) => (R)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36584", "l": "dTDP-alpha-D-fucose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691150", "l": "TFR2 dimer binds 2xholoTF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63946", "l": "an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12854", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose => dhurrin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41086", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0048028", "l": "galacturonan binding", "d": ["Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33262", "l": "4-aminoimidazole + H(+) + 2 H2O <=> N-formimidoylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41733", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate => [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30528", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => ADP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871265", "l": "YAP1 binds TEAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433711", "l": "Cis-homodimerization of nectins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62130", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dGDP => a 2'-deoxyribonucleoside 5'-phosphate + dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200879", "l": "Formation of a Nef:ARF1:CD4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050154", "l": "opheline kinase activity", "d": ["Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106262", "l": "1-acylglycerophosphoethanolamine O-acyltransferase activity", "d": ["Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA."], "t": []}, {"i": "RHEA:32995", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.n7", "l": "\"1-acylglycerophosphoethanolamine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72691", "l": "Formation of the 43S pre-initiation complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13944", "l": "ATP + D-glyceraldehyde <=> ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818574", "l": "TASP1 cleaves KMT2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57708", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64995", "l": "acetyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18185", "l": "adenosine + O2 = 5'-dehydroadenosine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672951", "l": "Inactive RAFs bind YWHAB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72668", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168459", "l": "Lyn activates ERK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75208", "l": "Ag(+)(out) => Ag(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49381", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38709", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72369", "l": "estrone 3-sulfate(in) + succinate(out) => estrone 3-sulfate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16654", "l": "D-gluconate + NADP(+) => 2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71178", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) <=> 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48110", "l": "2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005367", "l": "myo-inositol:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)."], "t": []}, {"i": "REACT:R-HSA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209924", "l": "Dopa is decarboxylated to dopamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362427", "l": "Hh-Np binds GPC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46054", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine => a 3'-end uridylyl-uridine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781897", "l": "USP11 deubiquitinates NFKBIA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62418", "l": "4-hydroxybenzaldehyde + acetyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917696", "l": "Cargo Sequestration (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53512", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68792", "l": "alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851139", "l": "STAT3-dependent MIR-21 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036290", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2214351", "l": "PLK1 phosphorylates GORASP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047406", "l": "beta-aspartyl-N-acetylglucosaminidase activity", "d": ["Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-D-glucosamine + L-asparagine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641229", "l": "TLE oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35508", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11336", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.99", "l": "\"3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198314", "l": "DAG stimulates protein kinase C-delta (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674531", "l": "AAMP binds EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050625", "l": "2-hydroxy-1,4-benzoquinone reductase activity", "d": ["Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H+ + NADH = benzene-1,2,4-triol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43530", "l": "2-aminomalonate semialdehyde + H(+) + NADH => L-serine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24771", "l": "7(1)-hydroxychlorophyllide a + NAD(+) <=> chlorophyllide b + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61851", "l": "cholesterol + UDP-alpha-D-glucose <=> cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53683", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20732", "l": "[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol", "d": [], "t": []}, {"i": "EC:1.8.4.16", "l": "\"thioredoxin:protein disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57365", "l": "H2O + NADH => (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54768", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874084", "l": "IPAF is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45424", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64483", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37850", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434073", "l": "IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75079", "l": "Formation of AT-AC C complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445700", "l": "Myosin Binds ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0032393", "l": "MHC class I receptor activity", "d": ["Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43492", "l": "7(1)-hydroxychlorophyll a + NADP(+) = chlorophyll b + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27741", "l": "2'-deoxyguanosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15159", "l": "H2O + homogentisate + NADP(+) => 4-hydroxyphenylacetate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27959", "l": "cytidine + H2O => cytosine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265301", "l": "Corticotropin cleavage from POMC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76454", "l": "(E)-4-coumaroyl alcohol + A <=> (E)-4-coumaraldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19326", "l": "H(+) + NADH + O2 + quinolin-4-ol => H2O + NAD(+) + quinoline-3,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76555", "l": "ergosterol + L-aspartyl-tRNA(Asp) = 1-(ergostan-3beta-yl)-L-aspartate + tRNA(Asp)", "d": [], "t": []}, {"i": "EC:2.3.2.37", "l": "\"ergosteryl-3beta-O-L-aspartate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679239", "l": "ULK complex translocates to the ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785684", "l": "Fibronectin degradation by CTSG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34787", "l": "a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10071", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35942", "l": "brevianamide F + dimethylallyl diphosphate <=> diphosphate + tryprostatin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163625", "l": "Glucagon binds to Glucagon receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18639", "l": "H(+) + NADPH => H2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12539", "l": "H(+) + L-arogenate <=> CO2 + H2O + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102637", "l": "5-aminolevulinate-CoA ligase activity", "d": ["Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP = 5-aminolevulinyl-CoA + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49575", "l": "Fe-coproporphyrin III + 2 H(+) <=> coproporphyrin III + Fe(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44234", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21292", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.153", "l": "\"phosphatidylinositol-4,5-bisphosphate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.193", "l": "\"ginsenosidase type I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432010", "l": "Aquaporin-1 passively transports water into cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52555", "l": "3-dehydro-L-erythronate + ATP <=> 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35671", "l": "(S)-5'-oxoaverantin + H(+) = (1'S,5'S)-averufin + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.142", "l": "\"5'-oxoaverantin cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22028", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": [], "t": []}, {"i": "EC:2.3.1.162", "l": "\"taxadien-5alpha-ol O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047962", "l": "glycine N-benzoyltransferase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015045", "l": "rubredoxin-NAD(P)+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426032", "l": "DAG is metabolized by DAGL to 2-AG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39598", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH <=> (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20428", "l": "2-oxoglutarate + ATP + hydrogencarbonate <=> (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12646", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] => (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22322", "l": "D-maltose + 2 phosphate => 2 alpha-D-glucose 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22188", "l": "an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10105", "l": "2-oxoglutarate + gibberellin A20 + O2 => CO2 + gibberellin A1 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27874", "l": "isochorismate = pyruvate + salicylate", "d": [], "t": []}, {"i": "EC:4.2.99.21", "l": "\"isochorismate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052907", "l": "23S rRNA (adenine(1618)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14460", "l": "glyoxylate + H2O + pentanoyl-CoA <=> 3-propylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429694", "l": "CERT1-2 complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748996", "l": "GST dimers cleave AZA to 6MP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428917", "l": "G13 activation by TP receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035489", "l": "guanine/guanine mispair binding", "d": ["Binding to a double-stranded DNA region containing a G/G mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874685", "l": "CBL binds MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31079", "l": "3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27311", "l": "naphthalene-1,2-diol + O2 => 2-hydroxychromene-2-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56961", "l": "a ribonucleoside 5'-triphosphate + pyruvate => a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19113", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061663", "l": "NEDD8 ligase activity", "d": ["Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate."], "t": []}, {"i": "EC:2.3.2.32", "l": "\"cullin-RING-type E3 NEDD8 transferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41816", "l": "a ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050243", "l": "pyruvate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: CoA + NADP+ + pyruvate = acetyl-CoA + CO2 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818682", "l": "MEN1 binds MLL2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693148", "l": "BCKDK phosphorylates BCKDH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18884", "l": "ATP + histamine + L-glutamate <=> ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707523", "l": "Hemes bind to BACH1:MAFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45968", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 = 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24321", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41582", "l": "5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate => 5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.-", "l": "\"Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52609", "l": "2-hydroxybutanoate + NADP(+) => 2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825631", "l": "MESP2 binds the RIPPLY2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617828", "l": "TRIP11:IFT20 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046714", "l": "borate binding", "d": ["Binding to borate, the anion (BO3)3-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399950", "l": "Phosphorylation of cofilin by LIMK-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730882", "l": "Phosphorylation of PKC-theta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50686", "l": "aniline + H(+) + L-glutamate => H2O + N(5)-phenyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70133", "l": "6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64973", "l": "dUDP + H2O => dUMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13180", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate <=> 3-oxopropanoate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31953", "l": "9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381087", "l": "Dimerization of PERK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63705", "l": "mycophenolate + UDP-alpha-D-glucuronate => H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25211", "l": "acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64492", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] = dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12687", "l": "H(+) + mycothione + NADPH => 2 mycothiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30606", "l": "15-cis-phytoene + A <=> AH2 + all-trans-phytofluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047413", "l": "N(alpha)-benzyloxycarbonylleucine hydrolase activity", "d": ["Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H2O + H+ = L-leucine + benzyl alcohol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951951", "l": "RUNX3 binds EP300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23520", "l": "acetyl-CoA + propanoate = acetate + propanoyl-CoA", "d": [], "t": []}, {"i": "EC:2.8.3.1", "l": "\"propionate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66386", "l": "scalar-17(25)-en-19-ol => (2E,6E,10E,14E)-geranylfarnesol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54869", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH => butanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11190", "l": "L-aspartate + NH4(+) => 3-cyano-L-alanine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9844955", "l": "CLN3 transports GalCer to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49278", "l": "CDP + phytyl diphosphate => CTP + phytyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20374", "l": "ATP + CoA + propanoate => AMP + diphosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050418", "l": "hydroxylamine reductase activity", "d": ["Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802933", "l": "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71100", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) => androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043920", "l": "aminopropylagmatine ureohydrolase activity", "d": ["Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0045547", "l": "dehydrodolichyl diphosphate synthase activity", "d": ["Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57756", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51097", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32517", "l": "(3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416358", "l": "G alpha (q) inhibits PI3K alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190260", "l": "FGFR2b binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159868", "l": "Furin cleaves pro-factor VII to factor VII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67343", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside <=> CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734687", "l": "ORC6 is phosphorylated on T195 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42720", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.166", "l": "\"23S rRNA (uridine(2552)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67166", "l": "6'-bromomelleolide F + FAD + 2 H2O => bromide + FADH2 + melleolide F + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74328", "l": "O-propanoyl-(R)-carnitine(in) => O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35409", "l": "4'-methoxyisoflavan-2',4,7-triol => H2O + medicarpin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047720", "l": "indoleacetaldoxime dehydratase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052910", "l": "23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807585", "l": "BPI binds LPS on the bacterial surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30328", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653180", "l": "GABA translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65123", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione <=> L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167292", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39672", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31008", "l": "(S)-2,3-epoxysqualene => beta-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23244", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.23", "l": "\"sym-norspermidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17140", "l": "prostaglandin H2 <=> thromboxane A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70899", "l": "histidine => urocanate + NH4+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29569", "l": "2 chloride(out) + H(+)(in) => 2 chloride(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59442", "l": "(S)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (-)-dehydrodiconiferyl alcohol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168412", "l": "MDP elicits a NOD2 response (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018490", "l": "4-hydroxyphenylpyruvate oxidase activity", "d": ["Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O2 = 2 (4-hydroxyphenyl)acetate + 2 CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64980", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042605", "l": "peptide antigen binding", "d": ["Binding to an antigen peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001072", "l": "transcription antitermination factor activity, RNA binding", "d": ["Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37946", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70285", "l": "4-acetamidobutanal + H2O2 + NH4(+) => H2O + N-acetylputrescine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950456", "l": "IL12B dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507875", "l": "Aquaporins passively transport urea into cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080106", "l": "7-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72703", "l": "UDP-alpha-D-galactose(in) + UMP(out) = UDP-alpha-D-galactose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68696", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66523", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693575", "l": "DNA-PKcs autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67809", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56338", "l": "ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70496", "l": "D-glucose(out) + 2 Na(+)(out) => D-glucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12126", "l": "CoA + trans-4-coumaroylshikimate => 4-coumaroyl-CoA + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28176", "l": "colneleate + H2O => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51669", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54933", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] => (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197958", "l": "FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168306", "l": "Concerted hemagglutinin pore formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191299", "l": "Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44835", "l": "(R)-carnitine + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73951", "l": "(2E,6E)-farnesyl diphosphate = beta-maaliene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9844860", "l": "ST3GAL5 transfers NeuNAc to ceramides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482772", "l": "Release of platelet cytosolic components (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132136", "l": "Vitronectin binds to C5b-C7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265177", "l": "Exocyst complex formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0016175", "l": "superoxide-generating NAD(P)H oxidase activity", "d": ["Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57081", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375144", "l": "Interaction of NCAM1:GFRalpha-1 with GDNF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19509", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.33", "l": "\"pteridine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58679", "l": "NADPH + O2 + rifamycin SV <=> H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938913", "l": "RUNX1 binds ELF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35806", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031822", "l": "type 1B serotonin receptor binding", "d": ["Binding to a type 1B serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34732", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295599", "l": "SPRY2 translocates to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53858", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => NADP(+) + ursocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015150", "l": "fucose transmembrane transporter activity", "d": ["Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68602", "l": "3-oxopropane-1-sulfonate + H2O => (2S)-3-sulfopropanediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46685", "l": "3-oxochol-4-en-24-oyl-CoA + A => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610722", "l": "CK1 phosphorylates p-GLI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24769", "l": "7(1)-hydroxychlorophyllide a + NAD(+) => chlorophyllide b + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824182", "l": "RBPJ:NICD1 and MSGN1 bind the LFNG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61840", "l": "brassicasterol + UDP-alpha-D-glucose = brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68298", "l": "CoA + O-dodecanoyl-L-seryl-[protein] => dodecanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030973", "l": "molybdate ion binding", "d": ["Binding to a molybdate ion (MoO4 2-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32631", "l": "erythromycin D + H(+) + NADPH + O2 = erythromycin C + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.154", "l": "\"erythromycin 12 hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645481", "l": "TIFA oligomerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753916", "l": "NAPQI binds proteins in hepatocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52781", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => 2-sulfenohercynine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694277", "l": "nsp8 generates RNA primers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193703", "l": "IKKbeta is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2213207", "l": "Formation of collagen networks (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37245", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13799", "l": "di-trans,poly-cis-dolichol + phosphate => a dolichyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76952", "l": "H2O + N-methyl-2-methylpropanamine + NAD(+) => 2-methylpropanal + H(+) + methylamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28786", "l": "H2O + L-cysteinylglycine <=> glycine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989770", "l": "Expression of PLIN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.33", "l": "\"fruit bromelain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40268", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64108", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59377", "l": "4-amino-4-deoxychorismate => 4-amino-4-deoxyprephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58819", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29865", "l": "ADP + GDP => AMP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29308", "l": "FMNH2 + methanesulfonate + O2 => FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25263", "l": "2-oxoglutarate + FADH2 => 2-hydroxyglutarate + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865050", "l": "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50397", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA => 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615721", "l": "HSPA8 binds substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201443", "l": "Type II receptor phosphorylates type I receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19970", "l": "hydroxylamine + O2 => H(+) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39204", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH => NADP(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641147", "l": "DACT1 binds DVL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61959", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50594", "l": "15-oxoprostaglandin F1alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016212", "l": "kynurenine-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44020", "l": "H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047461", "l": "(+)-delta-cadinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46846", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52467", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052792", "l": "endo-xylogalacturonan hydrolase activity", "d": ["Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31758", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17170", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25714", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328037", "l": "Fibrillin-1 binds integrins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042610", "l": "CD8 receptor binding", "d": ["Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762246", "l": "ANGPTL4 binds CDH11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.158", "l": "\"phospholipid:diacylglycerol acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34091", "l": "(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.134", "l": "\"5-phosphooxy-L-lysine phospho-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39533", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67732", "l": "uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52397", "l": "4-O-phospho-D-threonate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51098", "l": "19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39295", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42265", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA => 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32827", "l": "ATP + H2O + methionine(out) = ADP + H(+) + methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218824", "l": "p-6Y-VEGFR2 binds FYN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41935", "l": "H2O + hexadecanoyl-[ACP] <=> H(+) + hexadecanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321883", "l": "MSL acetylates histone H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32941", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55463", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32038", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44744", "l": "4 H(+) + 4 malonyl-CoA = (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": [], "t": []}, {"i": "EC:2.3.1.246", "l": "\"3,5-dihydroxyphenylacetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58354", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71277", "l": "2 Na(+)(in) + taurolithocholate 3-sulfate(in) => 2 Na(+)(out) + taurolithocholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465940", "l": "atRAL is reduced to atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416929", "l": "PTGFR binds PGF2a (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835358", "l": "p-TARBP2 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002466", "l": "Formation of allysine by LOX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74020", "l": "glycine(out) + L-alanine(in) => glycine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662466", "l": "XYLB phosphorylates D-xylulose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46877", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate => [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853745", "l": "RET binds GFRA1,GFRA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21251", "l": "a ribonucleoside 5'-triphosphate + RNA(n) <=> diphosphate + RNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874718", "l": "TTPA binds alpha-TOH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71168", "l": "glycine(out) + H(+)(in) + Na(+)(out) => glycine(in) + H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54807", "l": "2 4-sulfanylbutanoate + NAD(+) <=> 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004579", "l": "dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "d": ["Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63122", "l": "(11Z)-eicosenoate + NH4(+) => (11Z)-eicosenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35967", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.119", "l": "\"fumitremorgin C monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50337", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate => H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44019", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) <=> 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47555", "l": "glycodeoxycholate + H2O <=> deoxycholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76342", "l": "2 Na(+)(out) + urate(out) <=> 2 Na(+)(in) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141437", "l": "Formation of the MCC complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19726", "l": "H(+) + UDP-alpha-D-galacturonate => CO2 + UDP-beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102308", "l": "erythromycin D 3''-o-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17325", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.117", "l": "\"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "51.580637034214796", "identifiers": [{"i": "GO:0005261", "l": "monoatomic cation channel activity", "d": ["Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995330", "l": "COX10 transforms heme to heme O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22859", "l": "(7S)-salutaridinol + acetyl-CoA <=> (7S)-O-acetylsalutaridinol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140785", "l": "amino acid sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632667", "l": "SMO dimer binds ARRB and KIF3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23708", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.129", "l": "\"peptidoglycan glycosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704297", "l": "CHRM2 binds CHRM2 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24693", "l": "acetate + eugenol + NADP(+) <=> (E)-coniferyl acetate + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852317", "l": "PLK1 phosphorylates GTSE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.1", "l": "\"carboxypeptidase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250220", "l": "Homodimerization of ERBB4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59930", "l": "D-erythrose + H(+) + NADPH => erythritol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26138", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050261", "l": "ribose isomerase activity", "d": ["Catalysis of the reaction: ribofuranose = D-ribulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38282", "l": "(3R)-citramalate + succinyl-CoA <=> (3R)-citramalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76992", "l": "H(+) + NAD(+) + reduced 2[4Fe-4S]-[ferredoxin] => NADH + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733973", "l": "Bile salts bind FABP6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48687", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61768", "l": "rebaudioside A + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004915", "l": "interleukin-6 receptor activity", "d": ["Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45803", "l": "15-demethylaclacinomycin T + AH2 + O2 <=> 10-decarboxymethylaclacinomycin T + A + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50959", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33440", "l": "glyoxal + H2O + O2 => glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71164", "l": "homogentisate + O2 => maleylacetoacetate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848776", "l": "PTK6 phosphorylates DOK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69278", "l": "but-3-enenitrile + sulfate + sulfur => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59878", "l": "(indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44578", "l": "2-all-trans-nonaprenylphenol + CO2 => 4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.54", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48394", "l": "a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21828", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.7.7.2", "l": "\"ferredoxin--nitrate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41797", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36574", "l": "sphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65771", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55006", "l": "3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => 1-hydroxylimonen-2-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23103", "l": "ATP + dAMP <=> ADP + dADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17357", "l": "O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'", "d": [], "t": []}, {"i": "EC:1.8.3.2", "l": "\"thiol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114684", "l": "Phosphorylation of Syntaxin-4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050038", "l": "L-xylulose reductase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12329", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate => [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19897", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": [], "t": []}, {"i": "EC:1.14.13.39", "l": "\"nitric-oxide synthase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45540", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371590", "l": "HSP70 binds to HSP40:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016652", "l": "oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP."], "t": []}, {"i": "EC:1.6.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10413", "l": "ADP-D-ribose + H2O => AMP + D-ribose 5-phosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16502", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15665", "l": "aldehydo-D-glucose + L-lysyl-[protein] = H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63197", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH => (10bR,4aS)-oxomaritidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41928", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850794", "l": "SPINK6 binds KLK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851890", "l": "MET phosphorylates SHC1-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28810", "l": "glutathione + H2O <=> L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043871", "l": "delta1-piperideine-6-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47284", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.328", "l": "\"nicotine blue oxidoreductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49861", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008196", "l": "vitellogenin receptor activity", "d": ["Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36589", "l": "aldono-1,5-lactone + H(+) + NADPH => an aldopyranose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050548", "l": "trans-feruloyl-CoA hydratase activity", "d": ["Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357472", "l": "PAK1-3 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961671", "l": "E2F1 binds the ORC1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32125", "l": "citrate(out) + H(+)(out) => citrate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0001025", "l": "RNA polymerase III general transcription initiation factor binding", "d": ["Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37878", "l": "aklanonate + S-adenosyl-L-methionine <=> methyl aklanonate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16618", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate => alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862700", "l": "CMKLR1 binds Resolvin E1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41624", "l": "3-sulfinopropanoyl-CoA + H2O = H(+) + propanoyl-CoA + sulfite", "d": [], "t": []}, {"i": "EC:3.13.1.4", "l": "\"3-sulfinopropanoyl-CoA desulfinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36278", "l": "H(+) + NADPH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61371", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O <=> 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69705", "l": "beta-D-galactose + N-hexadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036307", "l": "23S rRNA (adenine(2030)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2321904", "l": "PTEN mRNA translation negatively regulated by microRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41379", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682010", "l": "ATG10:ATG12 binds ATG5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214845", "l": "CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433506", "l": "Phosphorylation of APS (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132085", "l": "Cleavage of C3 by surface-bound C3 convertases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047400", "l": "phosphonoacetate hydrolase activity", "d": ["Catalysis of the reaction: H2O + phosphonoacetate = acetate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40538", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75794", "l": "(S)-lactate(out) + Na(+)(out) <=> (S)-lactate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982065", "l": "Ligand-independent dimerization of overexpressed FGFR1b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69563", "l": "D-mannose(out) + H(+)(out) <=> D-mannose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70284", "l": "H2O + N-acetylputrescine + O2 => 4-acetamidobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14210", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444171", "l": "Receptor FFAR2 binds carboxylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067659", "l": "Assembly of hexameric IL-6 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34884", "l": "ATP + H2O + selenate(out) => ADP + H(+) + phosphate + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209120", "l": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605052", "l": "NR1H3 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986083", "l": "USP33 deubiquitinates ROBO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56704", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.12", "l": "\"3-[(E)-2-isocyanoethenyl]-1H-indole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420975", "l": "Ca impermeable AMPA receptor ligand binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64561", "l": "butan-2-ol + NAD(+) => butan-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663736", "l": "CHRNA9:CHRNA10 binds acetylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36472", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) => 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628444", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76564", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54707", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26067", "l": "ATP + hygromycin B <=> 4-O-phosphohygromycin B + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73407", "l": "(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250280", "l": "ROS oxidize thioredoxin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49608", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0019961", "l": "interferon binding", "d": ["Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73053", "l": "hydrogencarbonate(out) + taurocholate(in) => hydrogencarbonate(in) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73757", "l": "Binding of RRN3 to RNA Polymerase I (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20012", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose <=> H(+) + linamarin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837063", "l": "NS1 (1C) binds H2BC15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855375", "l": "PTPN22 dissociates from CSK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63493", "l": "H(+) + menadione + NADPH => menadiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37385", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11690", "l": "AMP + diphosphate + L-leucyl-tRNA(Leu) => ATP + L-leucine + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33816", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632652", "l": "Hh-Npp binds CDON and PTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73565", "l": "dGDP(in) + UTP(out) => dGDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76386", "l": "CYP1A2 S-demethylates 6MMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45542", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052793", "l": "pectin acetylesterase activity", "d": ["Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674095", "l": "PDGFRs bind type II TKI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54851", "l": "H(+) + hexan-3-one + NADPH + O2 <=> H2O + NADP(+) + propyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14636", "l": "ATP + H2O + Na(+)(in) <=> ADP + H(+) + Na(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73473", "l": "D-ornithine(out) + L-ornithine(in) => D-ornithine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964482", "l": "DREAM complex binds the E2F1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39665", "l": "a quinone + reduced coenzyme F420-(gamma-L-Glu)(n) => a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65731", "l": "2-oxoglutarate + hexyl sulfate + O2 <=> CO2 + H(+) + hexanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164527", "l": "Annealing of 3'-end of unwound transfer RNA primer with genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41281", "l": "octadecanoate + sphing-4-enine => H2O + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004082", "l": "bisphosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952128", "l": "RUNX3 binds TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203553", "l": "eNOS binds NOSIP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65370", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047590", "l": "5-dehydro-2-deoxygluconokinase activity", "d": ["Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72168", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) => 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15198", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37433", "l": "2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine => 12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382096", "l": "Formation of NR-NCOR Corepressor Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19531", "l": "H(+) + isovitexin 2''-O-beta-D-glucoside + UDP => isovitexin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44598", "l": "a fatty acid + H(+) + holo-[ACP] => a fatty acyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4341048", "l": "SUMOylation of RXRA with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009941", "l": "RNASEL cleaves viral ssRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318571", "l": "Defective MMADHC does not bind MMACHC:B12r (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74192", "l": "carbofuran + H(+) + H2O => 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18093", "l": "5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170159", "l": "Translocation of Cdc25 to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38408", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196964", "l": "RFK:Mg2+ phosphorylates RIB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63593", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796053", "l": "PRKCI phosphorylates NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110322", "l": "Formation of Pol zeta complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74989", "l": "erythrostominone(out) => erythrostominone(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66884", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0036238", "l": "gallate dioxygenase activity", "d": ["Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75081", "l": "Formation of AT-AC B Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11654", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23686", "l": "allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47860", "l": "a ganglioside GT1b (d18:1(4E)) + H2O = a ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174121", "l": "Association of Securin with Cdc20:APC/C complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65694", "l": "a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418856", "l": "Activation of Rac1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31313", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+) => (2R)-3-phosphoglycerate + ADP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32601", "l": "3-isopropenyl-6-oxoheptanoate + H(+) => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209177", "l": "LGS:ARM complex transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54616", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 = 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683764", "l": "Spike trimer translocates to ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625863", "l": "RETN gene expression is stimulated by FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602466", "l": "Activation of MT-MMPs by FURIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17162", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O => 2-oxopent-4-enoate + benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008800", "l": "beta-lactamase activity", "d": ["Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11529", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009085", "l": "DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39197", "l": "(3R)-hydroxytetracosanoyl-CoA + NADP(+) => 3-oxotetracosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23278", "l": "3-methyl-2-oxobutanoate + formaldehyde => 2-dehydropantoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23227", "l": "trans-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73797", "l": "FAICAR => IMP + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174119", "l": "Free APC/C phosphorylated by Plk1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.107", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30455", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55163", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59389", "l": "a fatty acid ester + H2O => a fatty acid + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43738", "l": "H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24482", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25074", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.92", "l": "\"hydroperoxide dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65560", "l": "2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61855", "l": "campesterol + UDP-alpha-D-glucose <=> campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690152", "l": "USP5 cleaves polyubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617182", "l": "PRKACA phosphorylates PLN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807585", "l": "BPI binds LPS on the bacterial surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18423", "l": "chloramphenicol 3-acetate + CoA => acetyl-CoA + chloramphenicol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851145", "l": "Translation of DNMT1 mRNA is repressed by miR-21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102752", "l": "1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)", "d": ["Catalysis of the reaction: a glucosylated glycogenin = a glycogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33430", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine <=> bacillithiol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61180", "l": "quercetin + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392513", "l": "Rap1 signal termination by Rap1GAPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13188", "l": "H2O + 4 porphobilinogen <=> hydroxymethylbilane + 4 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134954", "l": "DHX9 binds DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62345", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate => diphosphate + notoamide S", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047116", "l": "1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332363", "l": "Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67279", "l": "H2O + hexanal + NAD(+) <=> 2 H(+) + hexanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30376", "l": "(2E,6E)-farnesyl diphosphate => (+)-thujopsene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74026", "l": "L-alanine(in) + L-serine(out) <=> L-alanine(out) + L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54464", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12385", "l": "5,6-dihydrouracil + O2 => H2O2 + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76959", "l": "2-methylbutanamine + H2O + NADP(+) = 2-methylbutanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19578", "l": "luteolin + UDP-alpha-D-glucose => H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55677", "l": "chorismate + NH4(+) => (2S)-2-amino-4-deoxychorismate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32423", "l": "(1R,4R)-dihydrocarvone + A = (R)-carvone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60483", "l": "2 UTP <=> c-di-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24667", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72180", "l": "Cleavage of mRNA at the 3'-end (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166072", "l": "MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32086", "l": "CTP + pseudaminate <=> CMP-pseudaminate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54912", "l": "11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193636", "l": "p75NTR interacts with the NOGO receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19327", "l": "H2O + NAD(+) + quinoline-3,4-diol => H(+) + NADH + O2 + quinolin-4-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26473", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate <=> 16-feruloyloxyhexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52546", "l": "2-dehydro-D-erythronate + H(+) + NADH => D-erythronate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60695", "l": "(E)-non-2-enal + H2O + NADP(+) <=> (E)-non-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75596", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26080", "l": "methanesulfonate + NADH + O2 <=> formaldehyde + H2O + NAD(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718360", "l": "GNRHR binds GNRHR peptide agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.99", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26270", "l": "Co-precorrin-2 + 3 H(+) => Co(2+) + precorrin-2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109342", "l": "Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46661", "l": "H(+) + NADPH + progesterone => 5beta-pregnan-3,20-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033294", "l": "ectoine binding", "d": ["Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50941", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) => cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839635", "l": "CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0030983", "l": "mismatched DNA binding", "d": ["Binding to a double-stranded DNA region containing one or more mismatches."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66696", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55550", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58887", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 <=> A + chloramphenicol + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180540", "l": "Multi-ubiquitination of APOBEC3G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51874", "l": "diphosphate + osthenol => dimethylallyl diphosphate + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139909", "l": "Translocation of BMF to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76456", "l": "O-atom dealkylation of dextromethorphan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58041", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174967", "l": "NAT2 acetylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68888", "l": "2-methoxybenzoate + ATP + H(+) + NADPH = 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17242", "l": "an alpha-amino acid ester + H2O => an alcohol + an alpha-amino acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71268", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) => chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29612", "l": "H2O + NADP(+) + nitrous oxide => H(+) + NADPH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030109", "l": "HLA-B specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340124", "l": "CSN polymer binds CaPO4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57667", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40444", "l": "6-deoxy-6-sulfo-D-fructose + ATP => 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41283", "l": "H2O + N-tetracosanoyl-sphing-4-enine = sphing-4-enine + tetracosanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10106", "l": "CO2 + gibberellin A1 + succinate => 2-oxoglutarate + gibberellin A20 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72031", "l": "(E)-sinapyl alcohol + O2 = (E)-sinapaldehyde + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928625", "l": "PAKs autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691004", "l": "XPC binds RAD23 and CETN2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164832", "l": "ATPase synthesizes ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69786", "l": "(2-aminophenyl)succinate + succinyl-CoA <=> 2-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23898", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate => 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034854", "l": "4,4-dimethyl-3-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426162", "l": "SREBP1A,2 binds the HMGCR promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33077", "l": "6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65961", "l": "ATP + H2O + leukotriene C4(out) => ADP + H(+) + leukotriene C4(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635861", "l": "NUMB:ITCH binds GLI1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45451", "l": "H2O + N-(dodecanoyl)-sphinganine <=> dodecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43645", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA => 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54834", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705681", "l": "MPP5 binds SARS-CoV-2 E pentamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64179", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan <=> (9Z)-octadecenoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26033", "l": "3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69743", "l": "(S)-2-benzylsuccinate + succinyl-CoA = (S)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909721", "l": "Translocation of ISGF3 complex to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37893", "l": "15-demethylaclacinomycin T + methanol => aclacinomycin T + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417898", "l": "P2Y4 receptor can bind to UTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944454", "l": "mTORC1 phosphorylates MAF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990644", "l": "microtubule site clamp", "d": ["The binding activity of a molecule that attaches the spindle microtubules to the kinetochore."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18210", "l": "(2E)-geranyl diphosphate => (2S,4R)-bornyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694433", "l": "MIA2 binds PREB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60783", "l": "2-oxoglutarate + gibberellin A15 + O2 <=> CO2 + gibberellin A24 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183058", "l": "Expression of Adiponectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19953", "l": "a 2-oxocarboxylate + L-alanine = an L-alpha-amino acid + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.12", "l": "\"alanine--oxo-acid transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19641", "l": "(E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.12", "l": "\"4-coumarate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750942", "l": "USP14 deubiquitinates NLRC5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047600", "l": "abequosyltransferase activity", "d": ["Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103044", "l": "ribosomal protein S6 glutamate-glutamate ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804266", "l": "CHEK2 phosphorylates TTC5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21584", "l": "NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.7", "l": "\"propanediol-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61117", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66377", "l": "D-erythrose 4-phosphate + H2O => D-erythrose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029149", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419861", "l": "Melanospin is stimulated by light (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38455", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57332", "l": "H2O + 3 O2 + 3 propionate 3-nitronate = 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62754", "l": "(S)-2-methylbutanoate + H(+) + pravastatin diol lactone => H2O + pravastatin lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621571", "l": "CD209 binds ICAM2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0061778", "l": "intracellular chloride channel activity", "d": ["Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045436", "l": "lycopene beta cyclase activity", "d": ["Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052635", "l": "C-20 gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428262", "l": "ACER3 hydrolyzes phytoceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174446", "l": "Removal of remaining Flap from the C-strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218847", "l": "PAK2 binds NCK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112435", "l": "Formation of Elongin BC complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31820", "l": "(2E,6E)-farnesyl diphosphate => 5-epi-alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38963", "l": "ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14877", "l": "ATP + L-glutamate = ADP + L-glutamyl 5-phosphate", "d": [], "t": []}, {"i": "EC:2.7.2.11", "l": "\"glutamate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004967", "l": "glucagon receptor activity", "d": ["Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32622", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5606996", "l": "Soluble PROCR binds activated protein C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53775", "l": "chenodeoxycholate + lithocholoyl-CoA <=> chenodeoxycholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086040", "l": "sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981355", "l": "RASA1 binds RAS:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63453", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized 3PG-factor420-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68293", "l": "L-seryl-[protein] + nonanoyl-CoA => CoA + O-nonanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44723", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56888", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose = UDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13613", "l": "beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.90", "l": "\"diphosphate--fructose-6-phosphate 1-phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25834", "l": "H(+) + NADH + scyllo-inosine => 1D-chiro-inositol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5228992", "l": "ROCK1,ROCK2 are activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40114", "l": "butanoyl-CoA + H2O <=> butanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0033878", "l": "hormone-sensitive lipase activity", "d": ["Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28159", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714691", "l": "RAC3 binds ER effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16577", "l": "ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.7.7.53", "l": "\"ATP adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64115", "l": "an N-acyl-L-phenylalanine + H2O <=> a fatty acid + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754616", "l": "SARS-CoV-2 E pentamer transports Ca2+  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16588", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54801", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16384", "l": "L-arabinitol + NAD(+) <=> H(+) + L-xylulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0050485", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide."], "t": []}, {"i": "EC:1.21.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40082", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17638", "l": "squalene => hop-22(29)-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008903", "l": "hydroxypyruvate isomerase activity", "d": ["Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015164", "l": "glucuronoside transmembrane transporter activity", "d": ["Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18997", "l": "CTP + H(+) + phosphocholine = CDP-choline + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.15", "l": "\"choline-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937613", "l": "CRHBP binds CRH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.219", "l": "\"dihydroflavanol 4-reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333671", "l": "CLCAs self cleave (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446372", "l": "Association of  PARVA with TESK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007926", "l": "ATRX binds DAXX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420688", "l": "GABAB heterodimeric receptor binds GABA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66977", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76218", "l": "2'-deoxyguanosine(in) <=> 2'-deoxyguanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45358", "l": "(11Z)-eicosenoate + sphing-4-enine => H2O + N-(11Z-eicosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.504650478785891", "identifiers": [{"i": "GO:0016854", "l": "racemase and epimerase activity", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule."], "t": []}, {"i": "EC:5.1.-.-", "l": "\"Racemases and epimerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29664", "l": "H(+)(in) + xanthine(in) => H(+)(out) + xanthine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070984", "l": "SET domain binding", "d": ["Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730902", "l": "Oligomerization of p-CARMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17900", "l": "A + ethylbenzene + H2O <=> (S)-1-phenylethanol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77568", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545203", "l": "Deacetylation of cleaved cohesin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70829", "l": "L-arginine(out) + L-lysine(in) => L-arginine(in) + L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28083", "l": "(2S)-ethylmalonyl-CoA + NADP(+) => (2E)-butenoyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58213", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40384", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70982", "l": "Fumarate + H2O <=> (S)-Malate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047293", "l": "4-hydroxybenzoate nonaprenyltransferase activity", "d": ["Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391913", "l": "FPR2 binds FPR2 ligands (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72851", "l": "ADP(out) + AMP(in) = ADP(in) + AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68902", "l": "4-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-methoxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25846", "l": "(R)-carvone + H(+) + NADH => (1S,5R)-carveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34841", "l": "5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O => 4 H(+) + 5 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0015666", "l": "restriction endodeoxyribonuclease activity", "d": ["Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70629", "l": "2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56335", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O <=> AMP + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45067", "l": "H2O + N-hexadecanoylethanolamine <=> ethanolamine + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434650", "l": "MATEs mediate extrusion of xenobiotics (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667965", "l": "ANKLE2 binds PP2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32220", "l": "all-trans-lycopene => gamma-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13329", "l": "A + a 3-oxosteroid = a 3-oxo-Delta(1)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950426", "l": "Expression of lymphocyte cytosolic protein 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031731", "l": "CCR6 chemokine receptor binding", "d": ["Binding to a CCR6 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14199", "l": "ADP + H(+) + L-asparagine + phosphate => ATP + L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57108", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29319", "l": "H2O + sn-glycero-3-phosphoethanolamine = ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.37", "l": "\"leukocyte elastase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58129", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211356", "l": "Anthrax lef cleaves target cell MAP2K2 (MEK2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110307", "l": "REV1 binds AP-dsDNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20144", "l": "an S-alkyl-L-cysteine S-oxide <=> 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61292", "l": "(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382054", "l": "PDGF binds to extracellular matrix proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340214", "l": "CYGB binds O2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46099", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + dihydropinosylvin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35227", "l": "H(+)(out) + rifampicin(in) = H(+)(in) + rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676264", "l": "Formation of the SET1B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189406", "l": "4 PBGs bind to form HMB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59506", "l": "[protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein] => cholesterol + glycyl-L-cysteinyl-[protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23947", "l": "(E)-coniferol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102571", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] = N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71388", "l": "L-pipecolate(in) + Na(+)(in) => L-pipecolate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14448", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49637", "l": "H2O + methylglyoxal + O2 => H(+) + H2O2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69152", "l": "Removal of remaining Flap (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44024", "l": "(3R)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694790", "l": "E protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29757", "l": "(R)-lipoate(out) => (R)-lipoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45579", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29896", "l": "ATP + H2O + L-glutamine(out) => ADP + H(+) + L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37746", "l": "dimethylallyl phosphate + FMNH2 <=> phosphate + prenyl-FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004017", "l": "adenylate kinase activity", "d": ["Catalysis of the reaction: ATP + AMP = 2 ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74999", "l": "deoxyerythrostominol(in) = deoxyerythrostominol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67903", "l": "glutarate + succinyl-CoA <=> glutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66666", "l": "ADP + coproporphyrin III(out) + H(+) + phosphate => ATP + coproporphyrin III(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63756", "l": "flavokermesate + UDP-alpha-D-glucose = flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32942", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32627", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.58", "l": "\"glucan 1,3-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000007", "l": "low-affinity zinc ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.-", "l": "\"Omega peptidases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856945", "l": "PP2A methylation by LCMT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61568", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69173", "l": "Joining of adjacent Okazaki fragments (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000404", "l": "heteroduplex DNA loop binding", "d": ["Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37910", "l": "(9Z)-octadecenoate + O2 <=> (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805103", "l": "AURKA phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549129", "l": "OCT1 transports organic cations into hepatic cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70066", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42224", "l": "A + testosterone = AH2 + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63194", "l": "glycine betaine + 2 H(+) + phosphate => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.93", "l": "\"pyrrole-2-carboxylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42412", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) = ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": [], "t": []}, {"i": "EC:6.5.1.9", "l": "\"cyclic 2,3-diphosphoglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35118", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA <=> (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17016", "l": "H(+) + phosphoenolpyruvate <=> 3-phosphonopyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33550", "l": "H2O + lanosteryl hexadecanoate <=> H(+) + hexadecanoate + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73999", "l": "dimethylallyl diphosphate + quinolinone B = diphosphate + peniprequinolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690669", "l": "CD22 binds itself to form homo-oligomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450325", "l": "c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66041", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71000", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018580", "l": "nitronate monooxygenase activity", "d": ["Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71635", "l": "phosphate(in) + 2 thiosulfate(out) = phosphate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17110", "l": "FMNH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48424", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625482", "l": "PTK2 binds activated EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16669", "l": "H2O + NAD(+) + xanthine = H(+) + NADH + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21946", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+) => ATP + D-cellobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62522", "l": "an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55822", "l": "5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374665", "l": "DCC interaction with SIAH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19498", "l": "H(+) + L-aspartate => beta-alanine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875523", "l": "MET binds TNS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72631", "l": "Ca(2+)(in) + 3 Li(+)(out) = Ca(2+)(out) + 3 Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993802", "l": "HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390674", "l": "ADRB1 bind ADR,NAd (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561072", "l": "OCT3 mediates renal uptake of organic cations (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56091", "l": "a globoside MSGG + CMP-N-acetyl-beta-neuraminate <=> a globoside DSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33087", "l": "cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + chemical entity", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40140", "l": "(9Z)-octadecenoyl-CoA + H2O => (9Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48209", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047504", "l": "(-)-menthol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-menthol + NADP+ = (2S,5R)-menthone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34169", "l": "2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+) => 2,6-dihydroxypseudooxynicotine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654514", "l": "KAL1 binds FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980041", "l": "NOTCH1 binds DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51207", "l": "6-trans-leukotriene B4 + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62636", "l": "a hydroperoxide + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] = an alcohol + H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}, {"i": "EC:1.11.1.28", "l": "\"lipoyl-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34775", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51187", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O <=> H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57085", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74326", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) <=> O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20194", "l": "(R)-mevalonate + NADP(+) => (R)-mevaldate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011145", "l": "LHX2,(LHX9) binds the ROBO3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936979", "l": "RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050141", "l": "nitroethane oxidase activity", "d": ["Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.67", "l": "\"zingipain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67497", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O => 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050442", "l": "3-propylmalate synthase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45455", "l": "H2O + N-tetradecanoylethanolamine <=> ethanolamine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27403", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate => 2-hydroxychromene-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24249", "l": "glyoxylate + L-alanine => glycine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32406", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912450", "l": "ATR Kinase is recruited to unsynapsed regions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13936", "l": "all-trans-retinyl hexadecanoate + H2O <=> all-trans-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169402", "l": "ISGylation of E2 conjugating enzymes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31168", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) => 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008440", "l": "inositol-1,4,5-trisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70542", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008704", "l": "5-carboxymethyl-2-hydroxymuconate delta-isomerase activity", "d": ["Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34708", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948651", "l": "miR-106a,(miR106b) microRNA binds CNOT6L mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-178208", "l": "SMAD7 binds to SMURF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047452", "l": "protoaphin-aglucone dehydratase (cyclizing) activity", "d": ["Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788684", "l": "TRMT13 2'-O-methylates cytidine-4 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005332", "l": "gamma-aminobutyric acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450494", "l": "HuR binds mRNAs in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66364", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50614", "l": "(2E)-decenal + H(+) + NADPH => decanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61729", "l": "a 3-dehydro-D-guloside => a 3-dehydro-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823593", "l": "VWF variant does not bind to collagen type I  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905773", "l": "8-hydroxy-2'-deoxyguanosine DNA binding", "d": ["Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68709", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12326", "l": "L-asparagine + N-acetyl-D-glucosamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30769", "l": "D-glucuronate + H(+) => D-glucurono-3,6-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033913", "l": "glucan endo-1,2-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15838", "l": "L-glutamate + methylamine => N-methyl-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36892", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22450", "l": "ADP + H(+) + psi-UMP => ATP + pseudouridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52305", "l": "H2O + L-ectoine => (2S)-2-acetamido-4-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62451", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP <=> AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.135", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30762", "l": "5-methylcytosine + H(+) + H2O <=> NH4(+) + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033413", "l": "UGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203070", "l": "Association of profilin with monomeric actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32354", "l": "3 S-adenosyl-L-methionine + tricetin <=> 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12528", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31077", "l": "(2E)-dodecenoyl-CoA + H2O => (3S)-3-hydroxydodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12160", "l": "2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.125", "l": "\"2-deoxy-D-gluconate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73607", "l": "CTP(out) + dCTP(in) = CTP(in) + dCTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55851", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27443", "l": "D-xylose + H(+) + NADH => NAD(+) + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66172", "l": "H(+)(out) + L-cystine(out) = H(+)(in) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63844", "l": "[thioredoxin]-dithiol + cumene hydroperoxide = 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1467466", "l": "ABCA4 mediates atRAL transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450494", "l": "HuR binds mRNAs in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46033", "l": "H2O2 + tetradecanoate => (2S)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35566", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine <=> (9Z)-hexadecenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14060", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid <=> a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42014", "l": "11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH => cortisol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000327", "l": "PLK1 phosphorylates BORA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389350", "l": "Activation of Cdc42 by pVav1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28606", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.38", "l": "\"valine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400228", "l": "BMAL1 binds CLOCK,NPAS2 forming BMAL1:CLOCK,NPAS2 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835244", "l": "Expression of ZIC1 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985293", "l": "NKX3-2 binds RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001096", "l": "TFIIF-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667638", "l": "NBEA translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15530", "l": "bis(2-ethylhexyl)phthalate + H2O => 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210943", "l": "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50809", "l": "glutathione + prostaglandin J2 => prostaglandin J2-S-(S)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36410", "l": "ATP + hydrogencarbonate + L-threonine <=> diphosphate + H2O + L-threonylcarbamoyladenylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0004683", "l": "calmodulin-dependent protein kinase activity", "d": ["Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31015", "l": "H(+) + indole-3-carboxylate = CO2 + indole", "d": [], "t": []}, {"i": "EC:4.1.1.92", "l": "\"indole-3-carboxylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627089", "l": "CASP9 is phosphorylated at T412 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665727", "l": "FMNL2 binds CDC42:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377644", "l": "Release of CSK from SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69477", "l": "acetyl-CoA + L-lysine => CoA + H(+) + N(6)-acetyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1878002", "l": "XYLTs transfer Xyl to core protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0008083", "l": "growth factor activity", "d": ["The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70618", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0009035", "l": "type I site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211924", "l": "CYP4B1 12-hydroxylates ARA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001972", "l": "retinoic acid binding", "d": ["Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796060", "l": "NFE2L2 dependent NFE2L2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72152", "l": "estrone 3-sulfate(out) + glutarate(in) => estrone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11397", "l": "5-methyldeoxycytidine 5'-phosphate + ATP => 5-methyldeoxycytidine diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140132", "l": "iron-sulfur cluster carrier activity", "d": ["Binding to an iron-sulfur cluster and delivering it to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10738", "l": "an aldehyde + H(+) + NADH => a primary alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093332", "l": "p-EPHB phosphorylates SDC2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009817", "l": "Acitretin binds to RAR:RXR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17267", "l": "cis-aconitate => trans-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730892", "l": "Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018729", "l": "propionate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681294", "l": "IL6R binds IL6R inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809764", "l": "SBF1 binds MTMR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65539", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theacrine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63652", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42850", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) => 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420117", "l": "VEGFR2 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008813", "l": "chorismate lyase activity", "d": ["Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56737", "l": "H2O + O2 + retinal => H(+) + H2O2 + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442387", "l": "ZIP8 mediates zinc influx into cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008712", "l": "ADP-glyceromanno-heptose 6-epimerase activity", "d": ["Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226979", "l": "ADD1:ADD2 binds DMTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102737", "l": "p-coumaroyltriacetic acid synthase activity", "d": ["Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA = 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41843", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980691", "l": "RHOA GEFs activate RHOA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31939", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.110", "l": "\"2-hydroxy-1,4-benzoxazin-3-one monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75213", "l": "Cu(+)(in) => Cu(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22026", "l": "2 H(+) + NADH + trimethylamine N-oxide => H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669893", "l": "KIT binds type I TKIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813626", "l": "LEAP2 binds bacteria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33663", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33657", "l": "(9Z)-octadecenoate(in) => (9Z)-octadecenoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42538", "l": "pseudouridine(65) in tRNA => uridine(65) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12143", "l": "a 2'-deoxyribonucleoside + ATP <=> a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866851", "l": "CFTR transits to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25489", "l": "(2E)-geranyl diphosphate => (1S,5S)-alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21377", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => (S)-4-hydroxymandelate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9008043", "l": "MAPK8 phosphorylation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35667", "l": "a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59177", "l": "ADP + L-serine => AMP + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76249", "l": "ADP + ergothioneine(in) + H(+) + phosphate => ATP + ergothioneine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002460", "l": "P4HB binds Collagen chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632738", "l": "DDIT4 binds 14-3-3 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36626", "l": "3-phenylpyruvate + S-adenosyl-L-methionine <=> (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111237", "l": "Formation of ADAR1 homodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38823", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49877", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44297", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA => 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0090492", "l": "N,N-Dihydroxy-L-tryptophan decarboxylase activity", "d": ["Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786155", "l": "POLN binds ICL-DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30883", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) = D-glucarate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798020", "l": "TP53 binds the BTG2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55355", "l": "all-trans-retinol <=> 13-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53031", "l": "lithocholate + UDP-alpha-D-glucuronate <=> H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102201", "l": "(+)-2-epi-prezizaene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18764", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418662", "l": "Src activation following P2Y purinoceptor activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23957", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76505", "l": "4-O-beta-D-glucosyl-vanillin + acetate => 4-O-beta-D-glucosyl-trans-ferulate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14202", "l": "D-lyxose => D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12419", "l": "beta-alanyl-CoA <=> acryloyl-CoA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30931", "l": "L-cysteine + O-acetyl-L-homoserine = acetate + H(+) + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47579", "l": "a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444516", "l": "Formation of MSH2:MSH6 Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168885", "l": "Haptoglobin binds Hemoglobin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72667", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008442", "l": "3-hydroxyisobutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042957", "l": "dextrin transmembrane transporter activity", "d": ["Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20807", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16905", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389026", "l": "Galanin receptors can bind galanin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018572", "l": "EGFR phosphorylates NOTCH3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74706", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66293", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509827", "l": "ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626699", "l": "MARK4 binds ODF2 in the centriole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69690", "l": "genistein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + genistein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24879", "l": "A + L-sorbopyranose => 1-dehydro-L-sorbose + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0000993", "l": "RNA polymerase II complex binding", "d": ["Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875816", "l": "STAT3 binds activated MET receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190141", "l": "ALAD binds to Pb2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53708", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226999", "l": "ADD1:ADD3 binds DMTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692880", "l": "HRH3 binds Hist (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193668", "l": "p75NTR and RHOA-GDI interact (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23739", "l": "5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61508", "l": "peonidin + UDP-alpha-D-glucose = peonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29938", "l": "cytosine(in) + H(+)(in) <=> cytosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611839", "l": "β3-agonists bind ADRB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31787", "l": "H2O + tuberculosinyl diphosphate = (13R)-edaxadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18960", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69480", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.386", "l": "\"GlcNAc-beta-1,3-Gal beta-1,6-N-acetylglucosaminyltransferase (distally acting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350769", "l": "trans-Golgi Network Coat Activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15126", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) => CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25822", "l": "4-aminobutanal + H2O2 + propane-1,3-diamine => H2O + O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71683", "l": "2 H(+)(out) + L-aspartyl-glycine(out) = 2 H(+)(in) + L-aspartyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637806", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250217", "l": "ARL2:GTP binds ARL2BP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786118", "l": "IL13 binds IL13RA:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658438", "l": "SPRED dimer binds NF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27396", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52389", "l": "ATP + D-threonate => 4-O-phospho-D-threonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034901", "l": "endosulfan hydroxyether dehydrogenase activity", "d": ["Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55766", "l": "2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol => 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141341", "l": "SMOX-3 oxidises SPN to SPM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42049", "l": "3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835189", "l": "NCK1 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70593", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45036", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine = 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": [], "t": []}, {"i": "EC:1.7.2.9", "l": "\"hydroxylamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034278", "l": "stemar-13-ene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005324", "l": "long-chain fatty acid transporter activity", "d": ["Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805285", "l": "PLK3 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807872", "l": "Active ARF recruits coatomer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051435", "l": "BH4 domain binding", "d": ["Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798748", "l": "Exocytosis of secretory granule lumen proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39840", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34599", "l": "15-methylhexadecasphinganine + NADP(+) = 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52956", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60246", "l": "2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3] => 2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17342", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433488", "l": "Phosphorylation of SHP2 by SFKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018846", "l": "styrene-oxide isomerase activity", "d": ["Catalysis of the reaction: styrene oxide = phenylacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37623", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200396", "l": "Creatine transport across the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707505", "l": "Hemes bind to CLEC1B dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873918", "l": "Transphosphorylation of JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627107", "l": "XIAP binds CASP7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37404", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549304", "l": "OCT3 mediates renal clearance of organic cations (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14859", "l": "ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate => (indol-3-yl)acetate + ATP + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68907", "l": "3-phenylpropanoate + ATP + H(+) + NADPH <=> 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606789", "l": "ARSB hydrolyses DS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481007", "l": "Exocytosis of platelet alpha granule contents (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605051", "l": "Expression of PCK1 regulated by NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63406", "l": "6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,6-dichloropyridine-2,5-diol + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047668", "l": "amygdalin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30408", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] => oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43039", "l": "L-cysteine <=> 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73215", "l": "sulfate(out) + thiosulfate(in) = sulfate(in) + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.203", "l": "\"carboxymethylcellulase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64680", "l": "benzoyl-CoA + ethanol = CoA + ethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009488", "l": "IL34 binds CSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160039", "l": "serotonin-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when the biogenic amine serotonin has been bound by the channel complex or one of its constituent parts. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113429", "l": "Elongating transcript encounters a lesion in the template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832340", "l": "Expression of LHX1 during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190260", "l": "FGFR2b binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11248", "l": "[(3R)-hydroxybutanoate](n) + H2O = (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48429", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22176", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.94", "l": "\"leukotriene-B4 20-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16625", "l": "acetyl-CoA + hydrogen sulfide = CoA + thioacetate", "d": [], "t": []}, {"i": "EC:2.3.1.10", "l": "\"hydrogen-sulfide S-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016784", "l": "3-mercaptopyruvate sulfurtransferase activity", "d": ["Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753634", "l": "GGT dimers hydrolyse APAP-SG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3225867", "l": "Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58023", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> eupatolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16509", "l": "H(+) + oxalate = CO2 + formate", "d": [], "t": []}, {"i": "EC:4.1.1.2", "l": "\"oxalate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15460", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) <=> catechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13159", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH => (R)-glycerate + CO2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59772", "l": "D-sorbitol + O2 = D-sorbopyranose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811508", "l": "ING2-bound EP300 acetylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62788", "l": "2 fonsecin B + H(+) + NADPH + O2 = aurasperone B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32501", "l": "(1S,3R,5S)-sabinol + H2O + NADP(+) => (1R,5R)-sabinene + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54112", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + selina-4(15),7(11)-diene", "d": [], "t": []}, {"i": "EC:4.2.3.181", "l": "\"selina-4(15),7(11)-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59097", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose => diglucosyl-enterobactin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33289", "l": "1-pyrroline + AH2 + propane-1,3-diamine => A + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18427", "l": "3-dehydroquinate + H(+) + NADPH => L-quinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47795", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25777", "l": "scyllo-inosose => scyllo-inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635102", "l": "GPR161 is internalized (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451347", "l": "Activation of JNK by DSCAM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797100", "l": "CCNK binds CDK13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604732", "l": "Autocatalytic activation of proMMP13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40343", "l": "3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60619", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine <=> ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047478", "l": "aspartate-ammonia ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: L-aspartate + ATP + NH4 = L-asparagine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60505", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22279", "l": "2-oxoaldehyde + H2O + NAD(+) <=> a 2-oxocarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10907", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A <=> AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032547", "l": "purine deoxyribonucleoside binding", "d": ["Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45429", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42557", "l": "uridine(2819) in 21S rRNA => pseudouridine(2819) in 21S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.12", "l": "\"ribonuclease E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002428", "l": "Removal of fibrillar collagen N-propeptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28846", "l": "choline(in) + H(+)(in) <=> choline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110152", "l": "RNA NAD-cap (NAD-forming) hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+."], "t": []}, {"i": "RHEA:60880", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27303", "l": "7-chloro-L-tryptophan + O2 => 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57005", "l": "acetyl-CoA + streptothricin D => CoA + H(+) + N(beta)-acetylstreptothricin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72579", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619515", "l": "AMPK phosphorylates MAPT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76715", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64644", "l": "butan-1-ol + propanoyl-CoA = butyl propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45856", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68247", "l": "L-phenylalanine(in) + Na(+)(in) <=> L-phenylalanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52625", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31628", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine => 10-deoxymethymycin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016990", "l": "arginine deiminase activity", "d": ["Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19064", "l": "H2O + NADP(+) + nitrite <=> H(+) + NADPH + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694442", "l": "CNIH2,3 bind GRIA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62741", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39933", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050374", "l": "UDP-galacturonate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-galacturonate = CO2 + UDP-L-arabinose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48629", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035460", "l": "L-ascorbate 6-phosphate lactonase activity", "d": ["Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate."], "t": []}, {"i": "RHEA:28803", "l": "H2O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2429719", "l": "MCPH1 sequesters condensin II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36944", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65700", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045462", "l": "trichothecene 3-O-acetyltransferase activity", "d": ["Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62906", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49016", "l": "aurachin C epoxide = 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66140", "l": "acetyl-CoA + octopamine = CoA + H(+) + N-acetyloctopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380949", "l": "AMPK is dephosphorylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832209", "l": "Expression of DLL1 during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16966", "l": "(2E)-geranyl diphosphate => beta-myrcene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52191", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005140", "l": "interleukin-9 receptor binding", "d": ["Binding to an interleukin-9 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55279", "l": "9-cis-retinol + tetradecanoyl-CoA <=> 9-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32799", "l": "urea(in) = urea(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39957", "l": "(9Z)-octadecenoate + glycerol + H(+) => (9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73802", "l": "dimethylallyl diphosphate + isoechinulin A <=> dehydroechinulin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15397", "l": "dichloromethane + H2O = 2 chloride + formaldehyde + 2 H(+)", "d": [], "t": []}, {"i": "EC:4.5.1.3", "l": "\"dichloromethane dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102211", "l": "unsaturated rhamnogalacturonyl hydrolase activity", "d": ["Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44945", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483089", "l": "PE is converted to PS by PTDSS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647994", "l": "RAS proteins are depalmitoylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36620", "l": "2-hydroxydocosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986446", "l": "IL26 binds IL20RA:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202604", "l": "Formation of a heteromeric BMP receptor complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202721", "l": "JAM2 binds JAM3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31867", "l": "(S)-2,3-epoxysqualene = baccharis oxide", "d": [], "t": []}, {"i": "EC:5.4.99.51", "l": "\"baccharis oxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.25", "l": "\"bile acid CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008810", "l": "cellulase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54100", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48688", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": [], "t": []}, {"i": "EC:3.4.17.13", "l": "\"muramoyltetrapeptide carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709883", "l": "BIL:ALB scavenges O2.- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68803", "l": "H2O + nigerose <=> alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419153", "l": "5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250600", "l": "botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56669", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35771", "l": "5-deoxy-5-amino-3-dehydroshikimate = 3-amino-5-hydroxybenzoate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.144", "l": "\"3-amino-5-hydroxybenzoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68758", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine => 4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72657", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+) => 1-hydroxy-6-methoxyphenazine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62710", "l": "4-(indol-3-yl)butanoyl-beta-D-glucose + UDP => (indol-3-yl)butanoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372852", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64146", "l": "(9Z)-octadecenoate + L-methionine => H2O + N-(9Z-octadecenoyl)-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701064", "l": "TRPV1 binds TRPV1 agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964759", "l": "Alternative endo-mannosidase I route (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48206", "l": "(2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63616", "l": "prunetin + UDP-alpha-D-glucuronate = H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612501", "l": "SGK phosphorylates CREB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030197", "l": "extracellular matrix constituent, lubricant activity", "d": ["Functions as a lubricant for an extracellular matrix, such as a mucous membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41591", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65356", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37112", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26499", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46837", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63712", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28982", "l": "H(+)(out) + nitrite(in) <=> H(+)(in) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59376", "l": "4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate", "d": [], "t": []}, {"i": "EC:5.4.99.67", "l": "\"4-amino-4-deoxychorismate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12836", "l": "an N-acyl-D-glutamate + H2O <=> a carboxylate + D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17798", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42871", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine <=> caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928620", "l": "PAK1 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191656", "l": "Closure of gap junction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75750", "l": "10-oxooctadecanoate + H(+) + NADH <=> 10-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75448", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014433", "l": "RHOG GEFs activate RHOG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987223", "l": "IL10RB binds TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25441", "l": "(2E,6E)-farnesyl diphosphate => delta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140575", "l": "transmembrane monodehydroascorbate reductase activity", "d": ["Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction."], "t": []}, {"i": "RHEA:66524", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L-ascorbate(out) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168092", "l": "Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27791", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944227", "l": "Association of procollagen type XXII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73134", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine <=> 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937034", "l": "IRAK1 phosphorylates Pellino (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19353", "l": "glycocholate + H2O = cholate + glycine", "d": [], "t": []}, {"i": "EC:3.5.1.24", "l": "\"choloylglycine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36121", "l": "O-methyl gibberellin A9 + S-adenosyl-L-homocysteine => gibberellin A9 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050137", "l": "NADPH peroxidase activity", "d": ["Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45352", "l": "9,10-epoxyoctadecanoate + H2O = 9,10-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30301", "l": "a nucleobase within DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a methylated nucleobase within DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54218", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52404", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) = CO2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204500", "l": "CyP60 chaperones Basigin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65933", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine => 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49744", "l": "deoxyviolaceinate + H(+) + O2 = CO2 + deoxyviolacein + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59225", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + hydropyrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71492", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23438", "l": "2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450494", "l": "HuR binds mRNAs in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109701", "l": "PDPK1 binds PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15031", "l": "D-mannose + H(+) + NADH => D-mannitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32628", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14561", "l": "(E,E)-piperoyl-CoA + piperidine = CoA + H(+) + piperine", "d": [], "t": []}, {"i": "EC:2.3.1.145", "l": "\"piperidine N-piperoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15290", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose => [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74315", "l": "O-isobutanoyl-(R)-carnitine(in) = O-isobutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45553", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875816", "l": "STAT3 binds activated MET receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39332", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13831", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-alpha-D-rhamnose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963864", "l": "CUBN dissociates from 25(OH)D (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45113", "l": "gamma-tocopherol + H(+) + NADPH + O2 => 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69301", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33055", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O = diphosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.-", "l": "\"Protein-serine/threonine kinases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034008", "l": "R-linalool synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (R)-linalool + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003847", "l": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "d": ["Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665871", "l": "ADRM1 binds 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322427", "l": "Beta-catenin recruits CBP/p300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54553", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70060", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430183", "l": "NCK binds PAK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42385", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) => 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76873", "l": "acetophenone + H(+) + NADH + NH4(+) => (S)-1-phenylethylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36798", "l": "a ribonucleoside 5'-triphosphate + 2 H2O <=> a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40744", "l": "(20S)-ginsenoside Rd + 2 H2O => (20S)-ginsenoside C-K + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.75", "l": "\"poly(3-hydroxybutyrate) depolymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73636", "l": "CTP(out) + dGMP(in) => CTP(in) + dGMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61285", "l": "H2O + L-cystine + O2 => (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40895", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42268", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] = 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70091", "l": "ethanol + o-quinone methide = hydroxyclavatol ethyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46448", "l": "2 L-tyrosyl-tRNA(Tyr) = cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": [], "t": []}, {"i": "EC:2.3.2.21", "l": "\"cyclo(L-tyrosyl-L-tyrosyl) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685011", "l": "ATR activation at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62750", "l": "(S)-2-methylbutanoate + H(+) + monacolin J => H2O + lovastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59328", "l": "D-xylono-1,5-lactone + H2O = D-xylonate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.110", "l": "\"xylono-1,5-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23376", "l": "L-threonate + NAD(+) = 3-dehydro-D-erythronate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.129", "l": "\"L-threonate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004650", "l": "polygalacturonase activity", "d": ["Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701064", "l": "TRPV1 binds TRPV1 agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74164", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49193", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61520", "l": "AH2 + dopamine = 3-tyramine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77631", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75819", "l": "(5Z,8Z)-octadecadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75736", "l": "10-oxo-(12Z)-octadecenoate => 10-oxo-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71499", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50608", "l": "leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39717", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140339", "l": "phosphatidylglycerol transfer activity", "d": ["Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66162", "l": "CoA + H(+) + N-hexanoyltyramine => hexanoyl-CoA + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030373", "l": "high molecular weight B cell growth factor receptor activity", "d": ["Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44454", "l": "3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654510", "l": "FGFRL1 binds SPRED1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19512", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40616", "l": "H2O + tridecanoylglycerol => 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830668", "l": "LHX1 binds the NPNT gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40483", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32431", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32728", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA => a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29948", "l": "H(+)(in) + L-rhamnopyranose(in) => H(+)(out) + L-rhamnopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64023", "l": "GTP + L-seryl-[protein] <=> GDP + H(+) + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047240", "l": "lactosylceramide beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37368", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine => 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65729", "l": "2-oxoglutarate + hexyl sulfate + O2 => CO2 + H(+) + hexanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43294", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72270", "l": "chloride(out) + formate(in) <=> chloride(in) + formate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39345", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53643", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-amorphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.14", "l": "\"actinidain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9761344", "l": "USP18 binds IKBKG within IKK complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018683", "l": "camphor 5-monooxygenase activity", "d": ["Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170023", "l": "ionotropic sweet taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific soluble sweet compound has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62051", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30818", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> beta-nicotinamide D-riboside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692539", "l": "HRH1 binds HRH1 inverse agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59108", "l": "chenodeoxycholate + octyl beta-D-glucose = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69163", "l": "agmatine + H2O + O2 <=> H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034831", "l": "(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047877", "l": "ephedrine dehydrogenase activity", "d": ["Catalysis of the reaction: (1R,2S)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847977", "l": "FRK phosphorylates PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0005416", "l": "amino acid:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63302", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61560", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26406", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) => H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64479", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45747", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) <=> 7,8-dihydropteroate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34768", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821395", "l": "PAXIP1 binds PAGR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611851", "l": "ADRB2 bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102052", "l": "indole-3-acetyl-proline synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) = H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22755", "l": "A + H2O + uracil <=> AH2 + barbiturate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.260965879513137", "identifiers": [{"i": "GO:0005254", "l": "chloride channel activity", "d": ["Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995330", "l": "COX10 transforms heme to heme O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59861", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004557", "l": "alpha-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45004", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA = CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60264", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.364", "l": "\"[histone H3]-lysine(4) N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61626", "l": "5-aminopentanal + L-glutamate => 2-oxoglutarate + cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34174", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29048", "l": "a menaquinone + 2 H(+)(in) + H2 => a menaquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950456", "l": "IL12B dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5615668", "l": "AKR1C3 reduces atRAL to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70569", "l": "2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66006", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62504", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.74", "l": "\"3-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76338", "l": "L-aspartate(in) + L-tryptophan(out) <=> L-aspartate(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691004", "l": "XPC binds RAD23 and CETN2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36226", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371518", "l": "SIRT1 binds to HSF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42795", "l": "cholesterol + hexadecanoyl-CoA <=> cholesteryl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215406", "l": "PRMT5 binds WDR77 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65382", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011543", "l": "DCA binds PDK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852362", "l": "GTSE1 binds CDKN1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47645", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22550", "l": "(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27429", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388811", "l": "CD28 homodimer binds B7-1 homodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.19", "l": "\"cyclomaltodextrin glucanotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62997", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O => (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16328", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937814", "l": "RUNX3 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27395", "l": "dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38021", "l": "1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-decanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036011", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50404", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29452", "l": "H2O + phosphonate => H2 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39514", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044606", "l": "phosphocholine hydrolase activity", "d": ["Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835795", "l": "TFAP2A binds the PAX3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43374", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+) => an N-acylsphing-4-enine + dTDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68796", "l": "D-maltose + H2O = alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22256", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62292", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161282", "l": "Elastic fibres bind associated proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17112", "l": "FMNH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70859", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57621", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61356", "l": "ATP + H2O + methotrexate(in) = ADP + H(+) + methotrexate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693198", "l": "RHOD binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41293", "l": "dodecanoate + sphing-4-enine => H2O + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32836", "l": "4-(trimethylamino)butanoate(in) => 4-(trimethylamino)butanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55619", "l": "a carotenoid psi-end group <=> a carotenoid epsilon-end group", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36365", "l": "(9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+) => (9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811479", "l": "ING2 recruits EP300 to TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47374", "l": "a quinol + D-glucono-1,5-lactone => a quinone + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805205", "l": "GPR35 binds kynurenic acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42424", "l": "2-methylmaleate + H2O = (2R,3S)-3-methylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34821", "l": "curcumin + H(+) + NADPH => dihydrocurcumin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63294", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35649", "l": "3',3'-cGAMP + 2 diphosphate => ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35431", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": [], "t": []}, {"i": "EC:2.4.1.300", "l": "\"cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50506", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873946", "l": "OTUD3 deubiquitinates PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604831", "l": "NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45568", "l": "[heparosan](n) = [acharan](n)", "d": [], "t": []}, {"i": "EC:5.1.3.36", "l": "\"heparosan-glucuronate 5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76287", "l": "Na(+)(out) + thymine(out) = Na(+)(in) + thymine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114552", "l": "Thrombin-activated PARs activate G12/13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76152", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63682", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+) => (7R,8S)-7,8-diammoniononanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12091", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696807", "l": "N-glycan mannose trimming of Spike (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2250301", "l": "Formation of lysyl-pyrrole cross-links (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30187", "l": "(S)-dihydroorotate + a quinone = a quinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32415", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19646", "l": "a D-threo-aldose + NAD(+) => a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944232", "l": "Association of procollagen type XII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76891", "l": "2-hydroxy-1-phenylethan-1-amine + H2O + NAD(+) = 2-hydroxyacetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20193", "l": "(R)-mevalonate + NADP(+) = (R)-mevaldate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23643", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 <=> CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14308", "l": "ATP + L-proline + tRNA(Pro) <=> AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140800", "l": "gamma-aminobutyric acid:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53039", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77498", "l": "acetophenone + hydrogen cyanide <=> (2S)-2-hydroxy-2-phenylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114254", "l": "CYCS binds to APAF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77609", "l": "Binding of APOBEC-1 to form editosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14548", "l": "H2O + nicotinamide <=> NH4(+) + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733545", "l": "Bile salts and acids bind ALB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64318", "l": "2 (+)-geodin + 2 H2O => 2 dihydrogeodin + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20100", "l": "D-mannonate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015599", "l": "ATPase-coupled L-glutamine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19579", "l": "H(+) + luteolin 7-O-beta-D-glucoside + UDP => luteolin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617179", "l": "PRKACA phosphorylates TNNI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033945", "l": "oligoxyloglucan reducing-end-specific cellobiohydrolase activity", "d": ["Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008805", "l": "carbon-monoxide oxygenase activity", "d": ["Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53261", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58494", "l": "ADP + Fe(III)-enterobactin(in) + H(+) + phosphate => ATP + Fe(III)-enterobactin(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654573", "l": "Activated FGFR1 binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65664", "l": "citrate(out) + 4 Na(+)(out) = citrate(in) + 4 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190261", "l": "FGFR3c binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814387", "l": "CASP14 cleaves filaggrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-500717", "l": "Activation of GRIK3 homomer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35750", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epizingiberene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23768", "l": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.24", "l": "\"sphingosine N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197958", "l": "FPGS-2 transforms THF to THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784204", "l": "JAKs bind OSMR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170674", "l": "Dissociation of the Gi alpha:G olf complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111237", "l": "Formation of ADAR1 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20266", "l": "2-oxoglutarate + L-proline + O2 => cis-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-500717", "l": "Activation of GRIK3 homomer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56357", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22854", "l": "3-hydroxypyruvate + L-alanine => L-serine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191072", "l": "Synthesis of Cx43 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038164", "l": "thrombopoietin receptor activity", "d": ["Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449117", "l": "TXLNA (IL14) binds syntaxin1A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14755", "l": "acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67344", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68914", "l": "AMP + diphosphate + NADP(+) + propanal => ATP + H(+) + NADPH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67017", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63319", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12152", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38526", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050015", "l": "kievitone hydratase activity", "d": ["Catalysis of the reaction: kievitone hydrate = H2O + H+ + kievitone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047252", "l": "beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity", "d": ["Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211461", "l": "HNF1A-dependent synthesis of the L isoform of PKLR protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65082", "l": "asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane D + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606564", "l": "GALC hydrolyzes GalCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687465", "l": "MRN complex binds RBBP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36281", "l": "3-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theophylline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140383", "l": "4-hydroxytryptamine kinase activity", "d": ["Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.131", "l": "\"mannuronate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38513", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71439", "l": "L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40454", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045735", "l": "nutrient reservoir activity", "d": ["Functions in the storage of nutritious substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730904", "l": "Auto-ubiquitination of TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013978", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67985", "l": "N-acetyl-L-leucine => N-acetyl-D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39001", "l": "a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58502", "l": "glyoxylate + H2O + NAD(+) + trimethylamine => glycine betaine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715357", "l": "crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73800", "l": "SAICAR => AICAR + Fumarate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32488", "l": "CDP-choline + H2O => CMP + 2 H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60627", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53435", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77138", "l": "1D-myo-inositol 1,2-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390133", "l": "YKI transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68020", "l": "(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417820", "l": "P2Y9 receptor can bind to LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964280", "l": "Active Gq binds BTK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14761", "l": "H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.50", "l": "\"serine C-palmitoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804100", "l": "HMGB1 binds LPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169402", "l": "ISGylation of E2 conjugating enzymes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11309", "l": "acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191784", "l": "snRNA Cap hypermethylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0042979", "l": "ornithine decarboxylase regulator activity", "d": ["Binds to and modulates the activity of the enzyme ornithine decarboxylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168376", "l": "STIM1 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28932", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0000149", "l": "SNARE binding", "d": ["Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51797", "l": "deoxycohumulone + dimethylallyl diphosphate => colupulone + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.106", "l": "\"glucose-1,6-bisphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25216", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26209", "l": "L-allo-threonine = acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482857", "l": "CL transports from the ER to the IM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610802", "l": "GluN3A (GRIN3A), GluN3B (GRIN3B) NMDA receptors traffic to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381644", "l": "ER calcium channels open in response to activated PKA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.247531668414297", "identifiers": [{"i": "GO:0016895", "l": "DNA exonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389083", "l": "Autophosphorylation of PDGF alpha receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68611", "l": "Formation of ORC(1-5) complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13235", "l": "alpha-D-ribose 1-phosphate + guanine => guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33277", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73936", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] => desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13839", "l": "4,5-dihydroxyphthalate + H(+) + NADH => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444047", "l": "Receptor FFAR3 binds carboxylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24952", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.170", "l": "\"anhydro-N-acetylmuramic acid kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12992", "l": "a dolichyl beta-D-mannosyl phosphate + H2O <=> a dolichyl phosphate + D-mannose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.14", "l": "\"N-acetylglucosamine-6-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18603", "l": "3,4-dihydroxybenzoate + CO2 => 3,4-dihydroxyphthalate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35501", "l": "glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28015", "l": "S-adenosyl-L-methionine + thiocyanate => methyl thiocyanate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60661", "l": "1,4-benzoquinone + H(+) + NADH => hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10216", "l": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": [], "t": []}, {"i": "EC:2.7.11.23", "l": "\"[RNA-polymerase]-subunit kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693598", "l": "ATM phosphorylates NBN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17852", "l": "(3R)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76541", "l": "an N-acyl-sphinga-4,8-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210426", "l": "Glutamate synaptic vesicle docking and priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21756", "l": "deacetylisoipecoside + H2O = dopamine + secologanin", "d": [], "t": []}, {"i": "EC:4.3.3.3", "l": "\"deacetylisoipecoside synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389026", "l": "Galanin receptors can bind galanin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050295", "l": "steryl-beta-glucosidase activity", "d": ["Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76743", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecane = 7-tetradecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418856", "l": "Activation of Rac1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71640", "l": "K(+)(in) + Na(+)(in) => K(+)(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034909", "l": "6-hydroxypseudooxynicotine dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676133", "l": "CD74 binds MIF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68172", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 = CO2 + H2O + isodomoate A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008413", "l": "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031994", "l": "insulin-like growth factor I binding", "d": ["Binding to insulin-like growth factor I."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45138", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62172", "l": "an N-acylethanolamine phosphate + H2O = an N-acylethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23900", "l": "cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48191", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467775", "l": "Autocleavage of ESPL1 (Separase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65794", "l": "3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162657", "l": "Inactivation of Myt1 kinase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0103012", "l": "ferredoxin-thioredoxin reductase activity", "d": ["Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167083", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56177", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O => 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68747", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.16", "l": "\"dihydrophenazinedicarboxylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72691", "l": "Formation of the 43S pre-initiation complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28244", "l": "5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pratensein + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70960", "l": "D-tyrosine + H2O + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71289", "l": "chloride(in) + L-arginine(in) + 2 Na(+)(in) => chloride(out) + L-arginine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68591", "l": "(6R)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine <=> (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000074", "l": "TCN2 binds RCbl in the circulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404135", "l": "RBP4 binds atROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798749", "l": "Exocytosis of specific granule lumen proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34306", "l": "L-lysine <=> L-pipecolate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75263", "l": "isovitexin + O2 = 3'-dehydroisovitexin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44320", "l": "1-decanoylglycerol + H2O = decanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73797", "l": "FAICAR => IMP + H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76350", "l": "(2R,3S)-3-isopropylmalate(in) + sulfate(out) <=> (2R,3S)-3-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.249", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58539", "l": "glycine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76120", "l": "a dicarboxylate(in) + prostaglandin F2alpha(out) => a dicarboxylate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110158", "l": "TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947531", "l": "Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032141", "l": "single cytosine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65433", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69917", "l": "guanosine(in) + 2 Na(+)(in) => guanosine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604368", "l": "Autocatalytic activation of bound proMMP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68448", "l": "13-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60884", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44432", "l": "2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985343", "l": "RUNX2 binds SOX9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009676", "l": "low-affinity sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58966", "l": "H(+) + H2O2 + hexanoate => H2O + hexanal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.43", "l": "\"phosphogluconate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190261", "l": "FGFR3c binds to FGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19677", "l": "9'-cis-neoxanthin + O2 = (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58058", "l": "2-sulfinoacetaldehyde + L-alanine => hypotaurine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54482", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46282", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23308", "l": "(E)-sinapoyl-CoA + D-glucarate = 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.131", "l": "\"glucarate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16749", "l": "H2O + phosphonoacetate = acetate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.11.1.2", "l": "\"phosphonoacetate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578965", "l": "TNRC6A binds AGO2:miRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990595", "l": "mast cell secretagogue receptor activity", "d": ["Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31537", "l": "CO2 + guanidine + L-glutamate 5-semialdehyde + succinate => 2-oxoglutarate + L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112379", "l": "Recruitment of elongation factors to form elongation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11385", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35226", "l": "2-oxo-dADP + H2O <=> 2-oxo-dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3318415", "l": "ATF2 acetylates histone H2B, H4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19258", "l": "a secondary alcohol + NADP(+) => a ketone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951443", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45706", "l": "(E)-sinapaldehyde + H(+) + NADPH => (E)-sinapyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210426", "l": "Glutamate synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831166", "l": "Nascent N is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13089", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.7.2.2", "l": "\"nitrite reductase (cytochrome; ammonia-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68454", "l": "4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone => all-trans-10'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48613", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754775", "l": "SARS-CoV-2 M protein binds MAP1LC3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.402634366777022", "identifiers": [{"i": "GO:0046943", "l": "carboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)."], "t": []}, {"i": "REACT:R-HSA-390347", "l": "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10780", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156682", "l": "PLK1 phosphorylates NUDC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389532", "l": "PP2A binds CTLA4 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53931", "l": "a tertiary amine + S-adenosyl-L-methionine <=> a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70454", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54054", "l": "diphosphate + tau-cadinol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75692", "l": "2'-deoxyadenosine(in) => 2'-deoxyadenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73230", "l": "(3R)-citramalate(in) + sulfate(out) <=> (3R)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114683", "l": "Phosphorylation of Platelet Sec-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34940", "l": "H2O + menaquinone-8 + selenite => menaquinol-8 + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57760", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76744", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecane => 7-tetradecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388468", "l": "AVP(20-28) binds AVPR1A,B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205321", "l": "Interaction of KIT and sSCF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.8", "l": "\"glucosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24878", "l": "A + L-sorbopyranose = 1-dehydro-L-sorbose + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.32", "l": "\"L-sorbose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451152", "l": "MAP kinase p38 phosphorylates KSRP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71525", "l": "adenine(in) => adenine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54649", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65088", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.1", "l": "\"nitroalkane oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157933", "l": "NICD2 traffics to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21062", "l": "CoA + N-(3,4-dichlorophenyl)malonamate => 3,4-dichloroaniline + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62183", "l": "H2O + peregrinol diphosphate <=> diphosphate + viteagnusin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37936", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43517", "l": "2-carboxy-5-formylfuran + H2O => 2-carboxy-5-(dihydroxymethyl)furan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322422", "l": "Beta-catenin recruits SMARCA4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18071", "l": "D-arginine => L-arginine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40064", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25750", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11061", "l": "ATP + L-isoleucine + tRNA(Ile) => AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865605", "l": "BRWD1 binds SMARCA4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64221", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74723", "l": "Endosome acidification (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67659", "l": "2 Fe(III)-[cytochrome c] + NADPH <=> 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75349", "l": "thiocyanate(out) => thiocyanate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42746", "l": "H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036102", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683774", "l": "p-T68-CHEK2 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681980", "l": "ATG12 binds ATG7 dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73893", "l": "ADP + gamma-L-glutamylspermidine + H(+) + phosphate => ATP + L-glutamate + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46972", "l": "A + dihydrobisanhydrobacterioruberin = AH2 + bisanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602063", "l": "Defective CYP26B1 does not 4-hydroxylate atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18627", "l": "D-galactono-1,5-lactone + H(+) + NADPH => D-galactose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023159", "l": "Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87)) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13390", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56263", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose <=> 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507870", "l": "Aquaporins passively transport water out of cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047891", "l": "flavone 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432487", "l": "CWO binds to cwo gene and represses transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28032", "l": "[thioredoxin]-dithiol + GDP => [thioredoxin]-disulfide + dGDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70160", "l": "folate(in) + H(+)(in) => folate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007926", "l": "ATRX binds DAXX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44551", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67185", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine => (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20069", "l": "(Z)-phenylacetaldehyde oxime = H2O + phenylacetonitrile", "d": [], "t": []}, {"i": "EC:4.8.1.4", "l": "\"phenylacetaldoxime dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17492", "l": "H(+) + NADH + O2 + phthalate <=> cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000074", "l": "TCN2 binds RCbl in the circulation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10192", "l": "ATP + H2O + sulfate(out) = ADP + H(+) + phosphate + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301345", "l": "Elongator complex acetylates replicative histone H3, H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449077", "l": "Interleukin-16 is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38491", "l": "2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389463", "l": "Proteinase-activated receptors can bind thrombin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030411", "l": "scytalone dehydratase activity", "d": ["Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49986", "l": "(1R,2R)-12-hydroxyjasmonate + H2O + NADP(+) => H(+) + jasmonate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29016", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) => phosphate(in) + sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944215", "l": "Association of procollagen type XX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034809", "l": "benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696605", "l": "USP12, USP26 deubiquitinate AR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050477", "l": "acyl-lysine deacylase activity", "d": ["Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62141", "l": "dTMP + GTP => dTDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71250", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) <=> beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702629", "l": "sunitinib-resistant FLT3 mutants don't bind sunitinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75982", "l": "argipressin(out) <=> argipressin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41845", "l": "(3R)-hydroxyoctanoyl-[ACP] => (2E)-octenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45920", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032036", "l": "LTA4 translocates from neutrophil cytosol to platelet cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839016", "l": "PKR binds viral dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46751", "l": "carboxyphosphate + NH4(+) <=> carbamate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433711", "l": "Cis-homodimerization of nectins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76735", "l": "decane + O2 + reduced [NADPH--hemoprotein reductase] = 3-decanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191656", "l": "Closure of gap junction (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140010", "l": "D-aspartate transmembrane transporter activity", "d": ["Enables the transfer of D-aspartate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28978", "l": "H(+)(out) + L-asparagine(in) <=> H(+)(in) + L-asparagine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66353", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809238", "l": "MTMR7 binds MTMR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50192", "l": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.26", "l": "\"protein xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31955", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000401", "l": "open form four-way junction DNA binding", "d": ["Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73633", "l": "CTP(in) + dGTP(out) => CTP(out) + dGTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682377", "l": "LC3 de-lipidation by ATG4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48278", "l": "a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10226", "l": "ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12487", "l": "a ribonucleoside 5'-phosphate + H2O <=> a ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54842", "l": "H2O + NADP(+) + pentyl propanoate => H(+) + NADPH + O2 + octan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140890", "l": "H1 histone chaperone activity", "d": ["A histone chaperone that carries a H1 histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47488", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031858", "l": "pituitary adenylate cyclase-activating polypeptide receptor binding", "d": ["Binding to a pituitary adenylate cyclase-activating polypeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54452", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12303", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) <=> 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29901", "l": "ADP + D-xylose(in) + H(+) + phosphate => ATP + D-xylose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150043", "l": "structural constituent of synapse-associated extracellular matrix", "d": ["The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875183", "l": "CBL monoubiquitinates activated MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66645", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + trichobrasilenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050557", "l": "deacetylipecoside synthase activity", "d": ["Catalysis of the reaction: deacetylipecoside + H2O = dopamine + secologanin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17165", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-D-galactose", "d": [], "t": []}, {"i": "EC:2.7.7.32", "l": "\"galactose-1-phosphate thymidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56095", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66469", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => (17E)-cheilanthenediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782336", "l": "ADAT1 deaminates adenosine-37 in tRNA(Ala) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35301", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => 3-hydroxyoctadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17545", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] = [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": [], "t": []}, {"i": "EC:1.8.98.2", "l": "\"sulfiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47068", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77323", "l": "glyoxylate + N(omega)-methyl-L-arginine = 5-(3-methylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611852", "l": "ADRB3 bind ADR,NAd (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68401", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-gurjunene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975633", "l": "atROL binds to RBP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44169", "l": "dodecanoate + 2 H(+) + NADH => dodecanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850797", "l": "SPINK6 binds KLK13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23865", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44990", "l": "CoA + O-isobutanoyl-(R)-carnitine => (R)-carnitine + 2-methylpropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23106", "l": "D-ribulose 5-phosphate => D-arabinose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44095", "l": "ATP + CoA + nonadecanoate <=> AMP + diphosphate + nonadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004380", "l": "glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654159", "l": "Activated FGFR2 binds PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19209", "l": "codeine + NADP(+) = codeinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11501", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O => 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684008", "l": "NBN binds KPNA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74212", "l": "H2O + L-threonyl-tRNA(Lys) => L-threonine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76976", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O => (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174916", "l": "Formation of N-glucuronides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166753", "l": "Conversion of C4 into C4a and C4b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64507", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine <=> 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41615", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> D-ribose 2,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.210", "l": "\"4-methyl-5-nitrocatechol 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004847", "l": "urea carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H+ + phosphate + urea-1-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70875", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) = L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658430", "l": "NF1 is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15879", "l": "D-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432825", "l": "HMGB1 binds TLR4:LY96 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573296", "l": "Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10665", "l": "NAD(+) + perillyl alcohol => H(+) + NADH + perillyl aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080108", "l": "S-alkylthiohydroximate lyase activity", "d": ["Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36369", "l": "2-hydroxyglutarate + H(+) => (S)-alpha-hydroxyglutarate-gamma-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617927", "l": "FOXO4 binds ATXN3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694583", "l": "ABHD4 hydrolyses NAPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.4", "l": "\"3-oxosteroid 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680385", "l": "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023456", "l": "Dimerization of FGFR1 point mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42644", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] = diphosphate + holo-[malonate decarboxylase ACP]", "d": [], "t": []}, {"i": "EC:2.7.7.66", "l": "\"malonate decarboxylase holo-[acyl-carrier protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602484", "l": "Activation of proMMP11 by FURIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19318", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103088", "l": "2-(6'-methylthio)hexylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O = H+ + 2-(6'-methylthio)hexylmalate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28795", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73515", "l": "UDP(out) + UTP(in) = UDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74229", "l": "L-threonine + tRNA(Ile) => H2O + L-threonyl-tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21682", "l": "2-oxophytanate + H2O2 => (2S)-2-hydroxyphytanate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60411", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29700", "l": "dimethyl sulfoxide(in) => dimethyl sulfoxide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629218", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31493", "l": "H(+) + soyasaponin I + UDP => soyasaponin III + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218820", "l": "Src kinases phosphorylate VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244404", "l": "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790038", "l": "Expression of HSP90B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602004", "l": "Defective CYP24A1 does not 24-hydroxylate CALTOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67942", "l": "2-oxooctanoate + H2O2 => 2-hydroxyoctanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43427", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10755", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate <=> [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40236", "l": "coenzyme B + coenzyme M + fumarate => coenzyme M-coenzyme B heterodisulfide + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19985", "l": "NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67579", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5195402", "l": "CDK1 phosphorylates LPIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76512", "l": "5-deoxystrigol + H2O => 5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25395", "l": "(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": [], "t": []}, {"i": "EC:1.13.11.60", "l": "\"linoleate 8R-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13111", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADH => 2-acetamidofluorene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052883", "l": "tyrosine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-tyrosine = NH4 + trans-4-coumarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72428", "l": "chloride(in) + K(+)(in) => chloride(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48203", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA <=> reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018834", "l": "dichloromethane dehalogenase activity", "d": ["Catalysis of the reaction: dichloromethane + H2O = 2 chloride + formaldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65542", "l": "an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => a ganglioside GM3 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013004", "l": "RHOA binds effectors at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62194", "l": "H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase] => O2 + peregrinol + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21142", "l": "ADP + H(+) + IMP => ATP + inosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42087", "l": "9-cis-retinal + H2O + NAD(+) <=> 9-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204465", "l": "Basigin interacts with CD43 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41692", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28313", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63473", "l": "all-trans-hexaprenol + ATP => ADP + all-trans-hexaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210285", "l": "Trans-homophilic interaction of PECAM-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38722", "l": "(R)-carnitine(out) + ATP + H2O <=> (R)-carnitine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64203", "l": "an N-(fatty acyl)-L-leucine + H2O <=> a fatty acid + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13223", "l": "(R)-mevaldate + H(+) + NADH => (R)-mevalonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66111", "l": "2-oxobutanoate + L-cysteine <=> (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26529", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27562", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77245", "l": "CO2 + heptadecane => H(+) + hnu + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983147", "l": "Release of E3 from polyubiquitinated substrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30866", "l": "4-O-phospho-L-tyrosine + H2O <=> L-tyrosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31859", "l": "(S)-2,3-epoxysqualene = glutinol", "d": [], "t": []}, {"i": "EC:5.4.99.49", "l": "\"glutinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30578", "l": "3 menaquinone-8 + protoporphyrinogen IX <=> 3 menaquinol-8 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852317", "l": "PLK1 phosphorylates GTSE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63875", "l": "2-oxoglutarate + L-isoleucine + O2 <=> 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052845", "l": "inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18982", "l": "(R)-pantolactone + NADP(+) => 2-dehydropantolactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46291", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63457", "l": "(2E,6E,10E)-geranylgeraniol + CTP => (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71627", "l": "phosphate(in) + succinate(out) = phosphate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1878002", "l": "XYLTs transfer Xyl to core protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25678", "l": "ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": [], "t": []}, {"i": "EC:6.1.1.27", "l": "\"O-phosphoserine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617735", "l": "TXN disrupts FOXO4 complex with EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18839", "l": "CoA + taxuyunnanin C => 10-deacetyltaxuyunnanin C + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54021", "l": "L-lysyl-[protein] + propanoyl-CoA => CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51170", "l": "(R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine => (R)-adrenaline + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22933", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202692", "l": "PIP3 binds to RhoA and activates it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63164", "l": "H2O + N-tricosanoyl-taurine = taurine + tricosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.58", "l": "\"2-dehydro-3-deoxygalactonokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177922", "l": "EGFR dimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56283", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] <=> AMP + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11663", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932021", "l": "RUNX1 and ESR1 bind the GPAM gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654409", "l": "Activated FGFR3 binds FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875443", "l": "USP8 deubiquitinates LRIG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57977", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside C-K + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793947", "l": "Defective MOGS does not cleave glucose from an N-glycosylated protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25362", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693111", "l": "RHOF auto-activates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.50", "l": "\"noroxomaritidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656244", "l": "DRD2 binds DA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018754", "l": "ammelide aminohydrolase activity", "d": ["Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609921", "l": "SGTA binds Tail-anchored protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018421", "l": "UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity", "d": ["Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150047", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "d": ["G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69074", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28721", "l": "adenine(out) + H(+)(out) => adenine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45370", "l": "(4R)-hydroxysphinganine + (9Z)-octadecenoate => H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606564", "l": "GALC hydrolyzes GalCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57228", "l": "GDP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51154", "l": "3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide => 2 a thiol + L-cysteinyl-[sulfatase] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59300", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin = adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51048", "l": "5alpha-androstan-3,17-dione + A = AH2 + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0017046", "l": "peptide hormone binding", "d": ["Binding to a peptide with hormonal activity in animals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66776", "l": "ATP + H2O + uroporphyrin III(in) = ADP + H(+) + phosphate + uroporphyrin III(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36186", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141341", "l": "SMOX-3 oxidises SPN to SPM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47087", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29446", "l": "H(+)(in) + L-alanine(in) <=> H(+)(out) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39817", "l": "(R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.2", "l": "\"Serratia marcescens nuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047346", "l": "aldose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660192", "l": "VDR agonists bind VDR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649856", "l": "Oxidative damage to the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49938", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35198", "l": "L-quinate(in) <=> L-quinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48290", "l": "a ganglioside GD3 + CMP + H(+) => a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39056", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16159", "l": "2 Fe(II)-[leghemoglobin] + H(+) + NADP(+) => 2 Fe(III)-[leghemoglobin] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25665", "l": "(2E)-geranyl diphosphate <=> alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63509", "l": "a 1,2-saturated fatty acid + O2 => a (2R)-2-hydroperoxy fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43802", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200406", "l": "CPT1A,B transfers PALM to CAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75569", "l": "11-O-acetylcyathatriol + CoA => acetyl-CoA + cyathatriol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901149", "l": "salicylic acid binding", "d": ["Binding to salicylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.4.3", "l": "\"L-arginine:L-lysine amidinotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22068", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68841", "l": "(2Z,6E)-farnesyl diphosphate => (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791116", "l": "Expression of DDX11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56965", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51795", "l": "H(+) + NADH + O2 + salicylate <=> 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20190", "l": "5,6-dihydrouracil + NAD(+) => H(+) + NADH + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42045", "l": "a globoside GalGb4Cer (d18:1(4E)) + GDP-beta-L-fucose => a globoside Globo-H (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12709", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.137", "l": "\"phosphatidylinositol 3-kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59399", "l": "L-leucine <=> D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18613", "l": "4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.15", "l": "\"4-methoxybenzoate monooxygenase (O-demethylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.86", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793472", "l": "RIPK3 binds p-S9-PRKN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39185", "l": "(3R)-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.119", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875374", "l": "MET binds LRIG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419841", "l": "Light stimulates opsin receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56379", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42610", "l": "a plastoquinol + n H(+)(out) + NAD(+) => a plastoquinone + (n+1) H(+)(in) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51805", "l": "deoxyhumulone + dimethylallyl diphosphate => diphosphate + H(+) + lupulone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25221", "l": "H(+) + L-cysteate = CO2 + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69561", "l": "D-mannose(out) + H(+)(out) => D-mannose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34548", "l": "ATP + cob(II)yrinate + H2O + L-glutamine => ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.43", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218821", "l": "PDK1 phosphorylates PKC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050212", "l": "progesterone 11-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "61.529056167358632", "identifiers": [{"i": "GO:0140097", "l": "catalytic activity, acting on DNA", "d": ["Catalytic activity that acts to modify DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75041", "l": "acetyl-CoA(out) => acetyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57663", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30465", "l": "(+)-alpha-santalene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56832", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) = 2,3,6-trichlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19572", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863494", "l": "ASICs bind STOML3, (STOM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37267", "l": "H2O + L-alanyl-L-aspartate = L-alanine + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24404", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA", "d": [], "t": []}, {"i": "EC:4.1.3.4", "l": "\"hydroxymethylglutaryl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22548", "l": "H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.20", "l": "\"L-lysine 6-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601929", "l": "Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37246", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017084", "l": "delta1-pyrroline-5-carboxylate synthetase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110319", "l": "Elongation by POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033831", "l": "kojibiose phosphorylase activity", "d": ["Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033820", "l": "DNA alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374686", "l": "L1 interaction with Integrins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025033", "l": "NTF3 binds NTRK2 (TRKB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981621", "l": "Neuroglobin:oxygen dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854981", "l": "SHC1 in the RET complex is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18216", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) <=> CDP-D-glucose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53743", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O <=> [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35668", "l": "a triacylglycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018746", "l": "RHOQ binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050413", "l": "D-alanine 2-hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033438", "l": "ACC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77442", "l": "a ganglioside GQ1c + H2O <=> a ganglioside GT1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38216", "l": "D-glucose 6-phosphate + NAD(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15886", "l": "NADP(+) + propane-1,2-diol => (S)-lactaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33710", "l": "ATP + L-threonine <=> ADP + H(+) + O-phospho-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69198", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[beta-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65368", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25705", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174119", "l": "Free APC/C phosphorylated by Plk1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37604", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12468", "l": "avenacoside A + H2O = 26-desgluco-avenacoside A + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048472", "l": "threonine-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72976", "l": "2 ATP + 2 indole-3-pyruvate => 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12745", "l": "a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37462", "l": "1D-myo-inositol hexakisphosphate + ATP <=> 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008488", "l": "gamma-glutamyl carboxylase activity", "d": ["Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15116", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24544", "l": "H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.13", "l": "\"protein-lysine 6-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749253", "l": "Formation of MCM2-7 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047837", "l": "D-xylose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623643", "l": "RDH13 reduces atRAL to atROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007882", "l": "IL1F10 is cleaved (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35319", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437118", "l": "GPVI stimulates PI3K beta, gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416516", "l": "GRK2 sequesters activated Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37062", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate <=> AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362427", "l": "Hh-Np binds GPC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64309", "l": "3-aminobutanoate + pyruvate => acetoacetate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624956", "l": "PDE6D binds INPP5E (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70581", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69641", "l": "beta-D-glucose + phloretin => H2O + phlorizin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55994", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820538", "l": "MSGN1 binds the TBX6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37648", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103010", "l": "gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)", "d": ["Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60694", "l": "(E)-non-2-enoate + 2 H(+) + NADPH => (E)-non-2-enal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38499", "l": "a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201630", "l": "Caspase-mediated cleavage of Acinus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52400", "l": "4-O-phospho-D-threonate + NAD(+) = 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.14", "l": "\"lignin peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237129", "l": "Acireductone is created (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11749", "l": "fluoroacetaldehyde + L-threonine => 4-fluoro-L-threonine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19910", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40329", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12072", "l": "an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0032129", "l": "histone H3K9 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.48", "l": "\"carnitine--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683831", "l": "CCDC59 binds TTF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55679", "l": "chorismate + NH4(+) <=> (2S)-2-amino-4-deoxychorismate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191303", "l": "FDPS dimer transfers IPPP to GPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12524", "l": "L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62450", "l": "AMP + H(+) + L-glutamyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74730", "l": "Insulin degradation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664950", "l": "Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625424", "l": "The retrograde IFT train dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18631", "l": "ADP + H(+) + NADP(+) => ATP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71252", "l": "L-xylopyranose => L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44149", "l": "L-lysine => D-beta-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66308", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690740", "l": "CD22 binds B-cell receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938356", "l": "RMB14 binds RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73899", "l": "ATP + cadaverine + L-glutamate = ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34226", "l": "6-hydroxypseudooxynicotine + A + H2O <=> 2,6-dihydroxypseudooxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39591", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA = (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40543", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047627", "l": "adenylylsulfatase activity", "d": ["Catalysis of the reaction: 5'-adenylyl sulfate + H2O = AMP + 2 H+ + sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35642", "l": "(4S)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34735", "l": "a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11593", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O => dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28236", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O => L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25375", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714481", "l": "RAC2 binds effectors at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71522", "l": "uridine(out) <=> uridine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67687", "l": "a long-chain fatty acid(in) + ATP + H2O <=> a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638006", "l": "ARL3 hydrolyzes GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17845", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.193", "l": "\"5-amino-6-(5-phosphoribosylamino)uracil reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21230", "l": "beta-maltose => alpha-maltose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005112", "l": "Notch binding", "d": ["Binding to a Notch (N) protein, a surface receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595176", "l": "Defective CHSY1 does not transfer GalNAc to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49967", "l": "5,10-dihydrophenazine + O2 <=> H2O2 + phenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034816", "l": "anthracene 9,10-dioxygenase activity", "d": ["Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42950", "l": "5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57900", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869683", "l": "oxPL binds LBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001083", "l": "alpha-D-glucan binding", "d": ["Binding to alpha-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030622", "l": "U4atac snRNA binding", "d": ["Binding to a U4atac small nuclear RNA (U4atac snRNA)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033894", "l": "ribonuclease P4 activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938231", "l": "RUNX1:CBFB binds CREBBP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168871", "l": "Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56296", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] = pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44621", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52064", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034256", "l": "chlorophyll(ide) b reductase activity", "d": ["Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57657", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1balpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173740", "l": "Factor B binds to C3(H2O) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20712", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061652", "l": "FAT10 conjugating enzyme activity", "d": ["Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40654", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33341", "l": "CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45816", "l": "(S)-lactate + A = AH2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72584", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) => 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33843", "l": "H2O + N-tetracosanoylsphinganine = sphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34081", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38320", "l": "chorismate + H2O => (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57866", "l": "4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209072", "l": "PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433506", "l": "Phosphorylation of APS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671737", "l": "p-T774-PKN1 binds CDC25C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31271", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851866", "l": "MET binds RANBP10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19411", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH => cholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047373", "l": "acetoxybutynylbithiophene deacetylase activity", "d": ["Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29817", "l": "ADP + H(+) + L-proline(in) + phosphate => ATP + H2O + L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692376", "l": "BCL2 binds BCL2 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21693", "l": "CDP-glycerol + H2O => CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75613", "l": "plasmodiophorol C => H2O + plasmodiophorol A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32264", "l": "4-aminobutanoate + pyruvate => L-alanine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13578", "l": "a wax ester + H2O => a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36958", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA <=> (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071161", "l": "cyanophycin synthetase activity (L-arginine-adding)", "d": ["Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195275", "l": "Phosphorylation of APC component of the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37752", "l": "2-methyl-trans-aconitate => 2-methyl-cis-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380294", "l": "Loss of C-Nap-1 from centrosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681375", "l": "KIT binds ripretinib (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047744", "l": "chloridazon-catechol dioxygenase activity", "d": ["Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42711", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19725", "l": "H(+) + UDP-alpha-D-galacturonate = CO2 + UDP-beta-L-arabinopyranose", "d": [], "t": []}, {"i": "EC:4.1.1.67", "l": "\"UDP-galacturonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.25", "l": "\"bacteriophage T4 restriction endoribonuclease RegB\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389354", "l": "Activation of Vav1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11006", "l": "catechol + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665727", "l": "FMNL2 binds CDC42:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21426", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23437", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O => 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12983", "l": "glutathione + 2 H(+) + sulfite => H2O + O2 + S-sulfanylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30016", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77587", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35376", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O => (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72423", "l": "(E)-4-coumaroyl-AMP + CoA = (E)-4-coumaroyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375155", "l": "Interaction of NCAM1 with agrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67795", "l": "ribonucleotidyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69056", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27519", "l": "H2O + sphing-4-enine 1-phosphate => phosphate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944569", "l": "miR-25 microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080132", "l": "fatty acid alpha-hydroxylase activity", "d": ["Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain."], "t": []}, {"i": "REACT:R-HSA-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49719", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 <=> 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12462", "l": "fumarate + H2O => (S)-malate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56539", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46953", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47229", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634228", "l": "TRAF1 is cleaved by caspases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74452", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090590", "l": "protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382058", "l": "Nck binds to the active PDGF receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202233", "l": "Inactivation of Lck by Csk (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168885", "l": "Haptoglobin binds Hemoglobin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48261", "l": "a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate => a ganglioside GD1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0000095", "l": "S-adenosyl-L-methionine transmembrane transporter activity", "d": ["Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism."], "t": []}, {"i": "REACT:R-HSA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65094", "l": "aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane G + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005068", "l": "transmembrane receptor protein tyrosine kinase adaptor activity", "d": ["The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50354", "l": "3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase] => 3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12231", "l": "ATP + H2O + L-aspartate + L-glutamine <=> AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39544", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000120", "l": "CBLIF binds RCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29653", "l": "agmatine(out) + L-arginine(in) => agmatine(in) + L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42367", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45864", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62103", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173709", "l": "C7 binds C5b:C6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13600", "l": "1,4-diguanidinobutane + H2O <=> agmatine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0120294", "l": "peptide serotonyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)."], "t": []}, {"i": "RHEA:66552", "l": "L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61439", "l": "ADP + H2O <=> AMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75502", "l": "cholate(out) + n H(+)(out) <=> cholate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691131", "l": "CANDI binds CUL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645598", "l": "RRAGC,D hydrolyzes GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29386", "l": "dIMP + H2O <=> 2'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34742", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine <=> H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13491", "l": "berberine + 2 H2O2 => (S)-canadine + H(+) + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811454", "l": "MAPKs phosphorylate PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951676", "l": "RUNX3 binds TEADs and YAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55969", "l": "(+)-kolavelool + S-adenosyl-L-methionine => (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080069", "l": "7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372741", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27390", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O => pyruvate + salicylaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15717", "l": "daunorubicin + H(+) + NADPH + O2 = doxorubicin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63374", "l": "an S-acyl-L-cysteinyl-[protein] + CoA => an acyl-CoA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55241", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51501", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034942", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "d": ["Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11391", "l": "an 11beta-hydroxysteroid + NADP(+) <=> an 11-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249378", "l": "STING recruits TBK1 and STAT6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72474", "l": "citrate(out) + D-threo-isocitrate(in) <=> citrate(in) + D-threo-isocitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56544", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18001", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.52", "l": "\"phosphatidylinositol deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052872", "l": "tocotrienol omega-hydroxylase activity", "d": ["Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O ."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725855", "l": "NR3C2 binds NR3C2 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.34", "l": "\"monoprenyl isoflavone epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50918", "l": "AMP + an aldehyde + diphosphate + NADP(+) => a carboxylate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61802", "l": "AMP + diphosphate + L-alanyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47454", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA => (2E,5Z)-tetradecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55651", "l": "2-oxoglutarate + O2 + validoxylamine A <=> CO2 + H(+) + succinate + validoxylamine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.61", "l": "\"mycodextranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44966", "l": "dodecanoyl-CoA + NADP(+) => (2E)-dodecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62229", "l": "(E)-ascladiol + A => AH2 + patulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186785", "l": "RNF111 ubiquitinates SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201622", "l": "Caspase-mediated cleavage of gelsolin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050359", "l": "tropomyosin kinase activity", "d": ["Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61934", "l": "(S)-miconazole(out) + ADP + H(+) + phosphate => (S)-miconazole(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46850", "l": "5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517674", "l": "p-S158,221-HuR binds mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879459", "l": "F-actin capping protein is a heterodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000006", "l": "high-affinity zinc transmembrane transporter activity", "d": ["Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62455", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate <=> AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213201", "l": "Formation of collagen fibres (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57101", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thio-D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38702", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53142", "l": "H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60407", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62683", "l": "naphtopyrone YWA1 <=> H(+) + H2O + norrubrofusarin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0010242", "l": "oxygen evolving activity", "d": ["Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43127", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018852", "l": "dichloromuconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60472", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990882", "l": "CDK1 phosphorylates NUP98 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318752", "l": "miR-26A microRNAs bind PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018505", "l": "Estrogen-responsive EBAG9 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34202", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> bracteatin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448741", "l": "IL22RA2 binds IL22 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0046625", "l": "sphingolipid binding", "d": ["Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43446", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-ditetradecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37367", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine = 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53958", "l": "4-aminobutanoyl-[BtrI ACP] + CO2 => gamma-L-glutamyl-[BtrI ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205136", "l": "GTP-bound RAC contributes to JNK activation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034006", "l": "amorpha-4,11-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11845", "l": "acetyl-CoA + formate => CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678128", "l": "Spike glycoprotein of SARS coronavirus binds ACE2 on host cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36349", "l": "4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine => N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938176", "l": "RUNX1:CBFB binds the PF4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35726", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35484", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102628", "l": "costunolide 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: costunolide + NADPH + O2 + H+ = 3beta-hydroxycostunolide + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22454", "l": "n H(+) + (n+1) phosphate => [phosphate](n+1) + n H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65807", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37313", "l": "ADP + glycyl-L-glutamine(in) + H(+) + phosphate => ATP + glycyl-L-glutamine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39233", "l": "(3R)-hydroxytriacontanoyl-CoA + NADP(+) => 3-oxo-triacontanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650165", "l": "ASIC trimers bind H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783880", "l": "PIPOX oxidises PPCA to P6C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30981", "l": "AH2 + all-trans-3,4-didehydrolycopene => A + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004769", "l": "steroid delta-isomerase activity", "d": ["Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630055", "l": "NTHL1 D239Y does not cleave dihydrouracil (DHU) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016608", "l": "growth hormone-releasing hormone activity", "d": ["The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16806", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 => CO2 + deacetylcephalosporin C + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047476", "l": "3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity", "d": ["Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68323", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O <=> 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.7", "l": "\"cholate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16122", "l": "5,6-dihydrouracil + H2O => 3-(carbamoylamino)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14386", "l": "a dolichyl diphosphate + H2O => a dolichyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40815", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64062", "l": "1-phenyl-1,2-propanedione + H(+) + NADH => (S)-phenylacetylcarbinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42220", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44346", "l": "ADP + dapdiamide A + H(+) + phosphate => ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45716", "l": "H2O + N,N,N-trimethylglycyl-CoA = CoA + glycine betaine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55481", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047191", "l": "1-alkylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70103", "l": "H(+) + o-quinone methide + penilactone D = penilactone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202713", "l": "CD84 homodimerises (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034246", "l": "mitochondrial transcription factor activity", "d": ["Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.22", "l": "\"pectate trisaccharide-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021596", "l": "Membrane estrogen receptors bind SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2168886", "l": "Hemopexin binds Hemes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26184", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002046", "l": "opsin binding", "d": ["Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684052", "l": "PIAS4 SUMOylates MDC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0043236", "l": "laminin binding", "d": ["Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40574", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354097", "l": "Activation of Talin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61372", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45414", "l": "glycerol + H(+) + prostaglandin D2 => H2O + prostaglandin D2-1-glycerol ester", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38262", "l": "(2R,3S)-beta-methylmalyl-CoA <=> glyoxylate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40226", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> 4,8-dimethylnonanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51399", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin <=> CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044605", "l": "phosphocholine transferase activity", "d": ["Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12378", "l": "ADP + H(+) + L-fuculose 1-phosphate => ATP + L-fuculose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46170", "l": "AMP + diphosphate + pentanoyl-CoA => ATP + CoA + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37056", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate => 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17866", "l": "5,6,7,8-tetrahydropteridine + NADP(+) => 6,7-dihydropteridine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20984", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.41", "l": "\"sphingomyelin phosphodiesterase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15958", "l": "D-altronate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52413", "l": "4-phospho-D-erythronate + NAD(+) => 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75914", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54189", "l": "H2O + N-acetyl-L-phenylalanine => acetate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944706", "l": "miR-21 nonendonucleolytic RISC binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13708", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine <=> alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034280", "l": "ent-sandaracopimaradiene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509838", "l": "ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59246", "l": "acetate + ADP-D-ribose + H(+) => 3''-O-acetyl-ADP-D-ribose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710354", "l": "GSDME (1-270) binds cardiolipin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1250264", "l": "TXNIP binds reduced thioredoxin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693243", "l": "RHOD translocates to the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14254", "l": "guanosine 3',5'-bis(diphosphate) + H2O => diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004053", "l": "arginase activity", "d": ["Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863463", "l": "STON2 binds SYT proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853792", "l": "RET tyrosine phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114553", "l": "Activation of conventional Protein Kinase C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696605", "l": "USP12, USP26 deubiquitinate AR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46554", "l": "a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38235", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69721", "l": "(indol-3-yl)acetyl-AMP + diphosphate => (indol-3-yl)acetate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44422", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042960", "l": "antimonite secondary active transmembrane transporter activity", "d": ["Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032406", "l": "MutLbeta complex binding", "d": ["Binding to a MutLbeta mismatch repair complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785213", "l": "LIPC dimer binds heparin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701488", "l": "Active ALK phosphorylates JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24371", "l": "L-ornithine <=> L-proline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.158", "l": "\"carotene epsilon-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985943", "l": "p-Y701-STAT1 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31323", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.270", "l": "\"mannosylglucosyl-3-phosphoglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64557", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => 8-epi-ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69274", "l": "allyl isothiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41064", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647746", "l": "EML4 trimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218642", "l": "PTK2 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73701", "l": "ADP(out) + dATP(in) => ADP(in) + dATP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60901", "l": "a cytidine in RNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69053", "l": "RFC binding displaces Pol Alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953398", "l": "PIR oxygenates quercetin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34593", "l": "Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-7 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420128", "l": "SRC-1 phosphorylates SHB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72324", "l": "3 Na(+)(out) + thiosulfate(out) => 3 Na(+)(in) + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607736", "l": "MALT1 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.17", "l": "\"methylthioalkylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693347", "l": "HTR1A binds 5HT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41658", "l": "NADPH + sanguinarine => dihydrosanguinarine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0070026", "l": "nitric oxide binding", "d": ["Binding to nitric oxide (NO)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47532", "l": "chenodeoxycholate + NAD(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28957", "l": "aldehydo-D-glucuronate(out) + H(+)(out) => aldehydo-D-glucuronate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.449113659480474", "identifiers": [{"i": "GO:0016646", "l": "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}, {"i": "EC:1.5.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008661", "l": "1-deoxy-D-xylulose-5-phosphate synthase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40800", "l": "2-methylpropanoyl-CoA + H2O => 2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55160", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.8.7.3", "l": "\"ferredoxin:CoB-CoM heterodisulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71002", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47203", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) <=> (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43853", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA => 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050170", "l": "peptidyl-glutaminase activity", "d": ["Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50407", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] <=> 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34436", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine => 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018724", "l": "4-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38618", "l": "cyclic ADP-beta-D-ribose + H2O <=> ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381109", "l": "IRE1 binds IRE1 forming dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030623", "l": "U5 snRNA binding", "d": ["Binding to a U5 small nuclear RNA (U5 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67218", "l": "(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46315", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA <=> 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40844", "l": "FAD + H(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62204", "l": "1-propanol + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76869", "l": "acetophenone + H(+) + NADH + NH4(+) => (R)-1-phenylethylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10241", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) => a (2E)-enoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13564", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57398", "l": "3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine => (S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964287", "l": "G alpha (s):GTP:SRC dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43813", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41243", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine = N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604712", "l": "Initial activation of proMMP7 by trypsin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018780", "l": "dichloroacetate halidohydrolase activity", "d": ["Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199144", "l": "Nectin 2 binds CD226 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51821", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) => AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67203", "l": "H2O + N-acetyltyramine <=> acetate + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48877", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19960", "l": "2 5'-dehydroinosine + O2 <=> 2 9-riburonosylhypoxanthine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134962", "l": "DHX36 binds DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47819", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58885", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 => A + chloramphenicol + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174235", "l": "Association of Emi1 with Cdc20 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.1", "l": "\"ribonucleoside-diphosphate reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34874", "l": "methanol(out) <=> methanol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57573", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654167", "l": "Activated FGFR1 binds PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20532", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 <=> 2-cis-(+)-abscisate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24901", "l": "2 GTP <=> 3',3'-c-di-GMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702510", "l": "FLT mutants bind type II TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49539", "l": "2-amino-2-deoxy-D-gluconate <=> (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74820", "l": "glutathione(in) => glutathione(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862300", "l": "LYZ binds bacterial peptidoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67536", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70213", "l": "(S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose => 2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70455", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.24", "l": "\"sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706350", "l": "FLT3 phosphorylates CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49420", "l": "ATP + valienone = ADP + H(+) + valienone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042009", "l": "interleukin-15 binding", "d": ["Binding to interleukin-15."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177920", "l": "Binding of GRB2 to GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186785", "l": "PDGF-AA clevage by Furin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65590", "l": "4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465941", "l": "A REH hydrolyses 11cRE to 11cROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006873", "l": "IL21 receptor STAT binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14149", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.190", "l": "\"luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63620", "l": "ATP + dodecanoate + holo-[ACP] = AMP + diphosphate + dodecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.60", "l": "\"diadenosine hexaphosphate hydrolase (AMP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381668", "l": "cAMP activates EPAC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106408", "l": "diadenylate cyclase activity", "d": ["Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73748", "l": "(R)-noradrenaline(in) + 2 H(+)(out) => (R)-noradrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35886", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848829", "l": "CBL autoubiquitinates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754130", "l": "CDK4 inhibitors bind CDK4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37620", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008730", "l": "L(+)-tartrate dehydratase activity", "d": ["Catalysis of the reaction: L-tartrate = H2O + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32929", "l": "a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46768", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.27", "l": "\"sn-2 palmitoyl-lipid 9-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76944", "l": "3-aminohexane + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56402", "l": "(3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209738", "l": "VD3 binds GC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22880", "l": "2-oxoglutarate + L-arogenate = L-glutamate + prephenate", "d": [], "t": []}, {"i": "EC:2.6.1.79", "l": "\"glutamate--prephenate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67654", "l": "2'-deoxyadenosine + diphosphate => dADP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603784", "l": "PEX19:class I PMP binds PEX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21045", "l": "24-methylidenelophenol + S-adenosyl-L-methionine => (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11543", "l": "an N-acyl-D-mannosamine + NAD(+) <=> an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38437", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71272", "l": "H(+)(in) + thiamine(out) => H(+)(out) + thiamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35209", "l": "H(+) + IMP + phosphate => H2O + IDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0032394", "l": "MHC class Ib receptor activity", "d": ["Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23842", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+) => 3-(2,3-dihydroxyphenyl)propanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65133", "l": "2-oxoglutarate + O2 + preaustinoid A1 => CO2 + H2O + preaustinoid A2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43656", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16823", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADH => 6-phospho-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399712", "l": "Activation of Ca permeable AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388900", "l": "Neurotensin receptors can bind neurotensins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46602", "l": "[HPr protein]-O-phospho-L-serine + ADP + H(+) => [HPr protein]-L-serine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70150", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25838", "l": "5-deoxy-D-glucuronate + H(+) => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624365", "l": "Expression of PLTP regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050622", "l": "glycine dehydrogenase (cyanide-forming) activity", "d": ["Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028598", "l": "Phosphorylation of YAP by LATS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65670", "l": "a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508451", "l": "PTK2B is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19684", "l": "ATP + biotin + CoA <=> AMP + biotinyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69403", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66330", "l": "taurine(in) => taurine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947535", "l": "Cyclisation of GTP to precursor Z (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11792", "l": "H(+) + NADH + O2 + propene = 1,2-epoxypropane + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.69", "l": "\"alkene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33140", "l": "L-alanine(out) + L-aspartate(in) => L-alanine(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55600", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14834", "l": "(R)-mevalonate + CoA + 2 NAD(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43169", "l": "adenosine(34) in tRNA + H(+) + H2O => inosine(34) in tRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46341", "l": "ATP + N-hexadecanoylsphing-4-enine => ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40006", "l": "ent-copalyl diphosphate <=> (Z)-biformene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30932", "l": "L-cysteine + O-acetyl-L-homoserine => acetate + H(+) + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012835", "l": "GDIs block activation of RHOA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031210", "l": "phosphatidylcholine binding", "d": ["Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166792", "l": "Conversion of C2 into C2a and C2b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353484", "l": "Uracil glycosylase mediated recognition and binding of uracil opposite guanine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726848", "l": "SRC phosphorylates RHOU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202717", "l": "Heterodimerization of CEACAMs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74525", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysine + 2 S-adenosyl-L-homocysteine => L-lysine + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68603", "l": "ORC5 binds ORC2:ORC3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035375", "l": "zymogen binding", "d": ["Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52843", "l": "UDP-alpha-D-glucose + vanillate <=> 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44514", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829030", "l": "Nascent F signal peptide is cleaved at ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018788", "l": "atrazine chlorohydrolase activity", "d": ["Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247844", "l": "WNT ligands traffic to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196017", "l": "Dynamin is recruited to the gap junction plaque (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24236", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine = 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76043", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71512", "l": "phylloquinone(out) => phylloquinone(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57914", "l": "H(+) + L-glutaminyl-tRNA(Gln) + phosphate => 5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858387", "l": "Activated STAT3 positively regulates CEBPB transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029690", "l": "Caspase-6 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13938", "l": "4-sulfobenzoate + NADH + O2 => 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32166", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46559", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 <=> 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669854", "l": "KIT binds type II TKIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009485", "l": "IL34:CSF1 binds CSF1R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627089", "l": "CASP9 is phosphorylated at T412 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31800", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O => 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964619", "l": "PAK1 binds ARHGEF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59063", "l": "(20S)-ginsenoside Rg3 + H2O <=> (20S)-ginsenoside Rh2 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21924", "l": "3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75584", "l": "11-O-acetylcyathatriol + UDP-alpha-D-xylose => erinacine Q + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655193", "l": "KIAA0101 double monoubiquitination (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70767", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005358", "l": "high-affinity glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53610", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+) => 4-hydroxyestrone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24615", "l": "17beta-estradiol + NAD(+) <=> estrone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370505", "l": "PRLR is phosphorylated at Ser-349 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947499", "l": "Exchange of oxygen with sulfur in MoCo (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008701", "l": "4-hydroxy-2-oxovalerate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14282", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite => 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18824", "l": "acetyl-CoA + choline <=> acetylcholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51053", "l": "5alpha-androstan-3,17-dione + A => 5alpha-androst-1-ene-3,17-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840795", "l": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28230", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.150", "l": "\"costunolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.15.1.-", "l": "\"Acting on superoxide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24958", "l": "(R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate => H2O + N-acetyl-beta-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47409", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71202", "l": "L-ornithine(in) <=> L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58862", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669013", "l": "EDA-3 binds EDA2R (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675431", "l": "PP2A dephosphorylates RAF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606789", "l": "ARSB hydrolyses DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419253", "l": "5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64362", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429497", "l": "SLP-76 stimulates PLC gamma 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54657", "l": "linalool => (2E)-geraniol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050522", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP."], "t": []}, {"i": "EC:1.20.98.-", "l": "\"With other, known acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38994", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164834", "l": "Enzyme-bound ATP is released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655852", "l": "Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71520", "l": "uridine(out) => uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10750", "l": "CO2 + H2O => H(+) + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39131", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247842", "l": "Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35691", "l": "(2S)-versicolorone + NADP(+) = 1'-hydroxyversicolorone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16320", "l": "(S)-indan-1-ol + NAD(+) <=> H(+) + indan-1-one + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0061651", "l": "Atg12 conjugating enzyme activity", "d": ["Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34979", "l": "H(+)(in) = H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102455", "l": "anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029268", "l": "Phosphorylation and activation of PLCG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73998", "l": "geranylgeranyl diphosphate + H2O <=> (S)-(+)-nephthenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29904", "l": "ATP + D-ribose(out) + H2O => ADP + D-ribose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008389", "l": "RUNX2 binds HDAC6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75420", "l": "(R,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52634", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50962", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693125", "l": "RHOF binds effectors at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72904", "l": "butyrolactone II + dimethylallyl diphosphate => butyrolactone I + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45541", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727188", "l": "ATP4A:ATP4B binds PPIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173740", "l": "Factor B binds to C3(H2O) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48437", "l": "H2O + pentanoate ester => an aliphatic alcohol + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047309", "l": "dihydroxyphenylalanine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34459", "l": "8-hydroxycopalyl diphosphate + H2O = diphosphate + sclareol", "d": [], "t": []}, {"i": "EC:4.2.3.141", "l": "\"sclareol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68461", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid => a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204465", "l": "Basigin interacts with CD43 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71748", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) => 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247847", "l": "WLS is endocytosed to the early endosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847537", "l": "RAB43:GTP binds USP8NL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15741", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) = 2,5-dichlorohydroquinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950766", "l": "IL27RA dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786101", "l": "IL4 binds IL4R:JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950456", "l": "IL12B dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395340", "l": "Formation of hydroxyallysine by LOX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21136", "l": "(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine", "d": [], "t": []}, {"i": "EC:2.3.1.7", "l": "\"carnitine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16417", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59341", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A => 1'-hydroxy-demethylspheroidene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54778", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48389", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60978", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADH => (E)-4-hydroxynon-2-en-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:0016417", "l": "S-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111879", "l": "PIP2 hydrolysis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112510", "l": "IL6ST is tyrosine phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50268", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15542", "l": "DIMBOA + UDP-alpha-D-glucose => DIMBOA beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41463", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacylglycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46153", "l": "15-cis-phytoene + a plastoquinone => 15,9'-di-cis-phytofluene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49722", "l": "CO2 + 2 H2O + NAD(+) + violacein => 2 H(+) + NADH + 2 O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604732", "l": "Autocatalytic activation of proMMP13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44817", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419003", "l": "Interaction of Nectins with Afadin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031928", "l": "pyridoxine transmembrane transporter activity", "d": ["Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840401", "l": "DELE1(143-515) is released into the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003857", "l": "3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37830", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3221982", "l": "BANP binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706308", "l": "Active FLT3 binds to GRB10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799246", "l": "CHEK1 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130619", "l": "TGN-lysosomal vesicle coat assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692495", "l": "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617866", "l": "HOXC4 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623280", "l": "PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003756", "l": "protein disulfide isomerase activity", "d": ["Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12698", "l": "ATP + dGMP => ADP + dGDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34368", "l": "acrylamide + H2O => acrylate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53162", "l": "an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + N-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48244", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636457", "l": "SapM dephosphorylates PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938231", "l": "RUNX1:CBFB binds CREBBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964278", "l": "G protein alpha (s):GTP binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49543", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate <=> (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61650", "l": "AMP + diphosphate + salicyl-[non-ribosomal peptide synthase] => ATP + holo-[non-ribosomal peptide synthase] + salicylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35473", "l": "(+)-pisatin + H(+) + S-adenosyl-L-homocysteine => (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32689", "l": "diphosphate + tricyclene => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23975", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) <=> (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647660", "l": "GSDME (1-270) binds PIPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811412", "l": "Active ARF recruits coatomer to the Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873927", "l": "Release of STAT1 dimer from active receptor unit (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56351", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0015923", "l": "mannosidase activity", "d": ["Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44863", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA <=> CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388503", "l": "Oxytocin receptor bind oxytocin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33090", "l": "cyclic dehypoxanthinylfutalosinate <=> 1,4-dihydroxy-6-naphthoate + chemical entity", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12816", "l": "L-glutamate <=> D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0046870", "l": "cadmium ion binding", "d": ["Binding to a cadmium ion (Cd)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023592", "l": "MECP2 binds HTT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54424", "l": "L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60180", "l": "ATP + D-fructose(out) + H2O = ADP + D-fructose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60370", "l": "urate(in) => urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.3", "l": "\"haloacetate dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68566", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin => 6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59091", "l": "D-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20512", "l": "ATP + viomycin <=> ADP + H(+) + O-phosphoviomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500708", "l": "GRIK3 homomer binds glutamate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66002", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24456", "l": "alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52146", "l": "(R)-2-(phosphonomethyl)malate + CoA + H(+) => 3-phosphonopyruvate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005001", "l": "transmembrane receptor protein tyrosine phosphatase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102717", "l": "DIBOA-glucoside oxygenase activity", "d": ["Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate = TRIBOA-beta-D-glucoside + succinate + carbon dioxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43395", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69725", "l": "(indol-3-yl)acetyl-CoA + AMP + H(+) => (indol-3-yl)acetyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65788", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009488", "l": "IL34 binds CSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14129", "l": "cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.176", "l": "\"12alpha-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62244", "l": "a cytidine(6-4)thymidine in DNA = a cytidine-thymine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166041", "l": "Transfer of LPS onto TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63910", "l": "ADP + H(+) + phosphate + pravastatin(out) => ATP + H2O + pravastatin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46374", "l": "a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51697", "l": "desmethylxanthohumol + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18535", "l": "CO2 + serotonin => 5-hydroxy-L-tryptophan + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39701", "l": "(2E,13Z)-eicosadienoyl-CoA + H2O => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51210", "l": "12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH => 20-hydroxy-leukotriene B4 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69131", "l": "glyoxylate + L-leucine <=> 4-methyl-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49272", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] = calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47755", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine <=> 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43539", "l": "2 D-glyceraldehyde 3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851890", "l": "MET phosphorylates SHC1-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690404", "l": "Expression of SOX9 in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070573", "l": "metallodipeptidase activity", "d": ["Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59691", "l": "D-maltoheptaose + O2 <=> D-maltoheptaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190520", "l": "Association of Golgi  transport vesicles with microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69790", "l": "(2-aminophenyl)succinate + succinyl-CoA <=> 3-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70180", "l": "2 D-maltotetraose => alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420128", "l": "SRC-1 phosphorylates SHB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428533", "l": "Inactivation of CDC42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69889", "l": "Na(+)(in) + uridine(in) => Na(+)(out) + uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31883", "l": "(S)-2,3-epoxysqualene = delta-amyrin", "d": [], "t": []}, {"i": "EC:5.4.99.55", "l": "\"delta-amyrin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54780", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53289", "l": "3-dehydro-scyllo-inosose + H2O => 5-dehydro-L-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396029", "l": "Latent TGF-beta-3 binds integrins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114558", "l": "Thrombin-activated PARs activate Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32595", "l": "7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52793", "l": "chlorophyllide a + 2 H(+) => Mg(2+) + pheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56907", "l": "an acyl-AMP + CoA <=> AMP + an acyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26260", "l": "dehydroabietadienol + H(+) + NADPH + O2 <=> dehydroabietadienal + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37050", "l": "H(+)(out) + L-histidine(out) <=> H(+)(in) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15315", "l": "acetaldehyde + NH4(+) => ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.79", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357479", "l": "p-AXL binds PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15077", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine = (R)-pantetheine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.30", "l": "\"pantothenoylcysteine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21707", "l": "H2O + L-tyrosine <=> NH4(+) + phenol + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56348", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52563", "l": "2-dehydro-D-erythronate <=> 3-dehydro-D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.91", "l": "\"flavivirin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71547", "l": "5-phosphomethyl-dUMP in DNA + glycine = 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17286", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625426", "l": "Retrograde IFT (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010177", "l": "2-(2'-methylthio)ethylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23430", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62730", "l": "(+)-malbrancheamide D + FADH2 => (+)-malbrancheamide B + bromide + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40858", "l": "FAD + H(+) + undecanoyl-CoA <=> FADH2 + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51716", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72722", "l": "eIF2 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20994", "l": "16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine => 16-hydroxytabersonine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65667", "l": "citrate(out) + 4 Na(+)(out) <=> citrate(in) + 4 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47782", "l": "a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31432", "l": "(2E,6E)-farnesyl diphosphate => (-)-beta-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53493", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) => 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69739", "l": "phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26463", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine => 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932084", "l": "RUNX1 and ESR1 bind the AXIN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9675026", "l": "Formation of the MLL1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66584", "l": "3-oxocholestane + A + H2O = 25-hydroxy 3-oxocholestane + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64345", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27300", "l": "2 H(+) + NADH + phthalate => 2-formylbenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193642", "l": "Binding of pro-NGF to p75NTR:sortilin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.131", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53183", "l": "D-erythrose <=> D-erythrulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33295", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48367", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67844", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22616", "l": "2 H(+) + O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O", "d": [], "t": []}, {"i": "EC:1.21.3.5", "l": "\"sulochrin oxidase [(-)-bisdechlorogeodin-forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50927", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466710", "l": "Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9833635", "l": "p-PKR dimer localizes to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848751", "l": "PTK6 binds AKT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371527", "l": "HSF1 trimer translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110239", "l": "MPG glycosylase mediated recognition and binding of ethenoadenine  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54951", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] <=> (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13970", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013435", "l": "RHOD auto-activates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156930", "l": "GTP-binding activates eEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44416", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097163", "l": "sulfur carrier activity", "d": ["Covalently binding to sulfur and delivering it to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52724", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate = a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.38", "l": "\"aliphatic desulfoglucosinolate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18107", "l": "ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20715", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28793", "l": "H(+) + NADH + thymine => 5,6-dihydrothymine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52991", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine <=> [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41135", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49231", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) <=> diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24201", "l": "4-aminobenzoate + H(+) => aniline + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106153", "l": "phosphorylated histone binding", "d": ["Binding to a histone in which a residue has been modified by phosphorylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794444", "l": "ALB binds Cipro (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69053", "l": "RFC binding displaces Pol Alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937814", "l": "RUNX3 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625904", "l": "Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39895", "l": "7-deoxyloganetate + UDP-alpha-D-glucose = 7-deoxyloganate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.323", "l": "\"7-deoxyloganetic acid glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74707", "l": "Binding of IRS to insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174731", "l": "Degradation of newly synthesized ApoB-48 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20780", "l": "ATP + GMP = ADP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34513", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20248", "l": "ATP + streptomycin <=> 3''-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-190141", "l": "ALAD binds to Pb2+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21180", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = D-glucose + indole-3-acetyl-1D-myo-inositol", "d": [], "t": []}, {"i": "EC:2.3.1.72", "l": "\"indoleacetylglucose--inositol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32360", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68396", "l": "a percarboxylic acid + H2O = a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33825", "l": "NAD(+) + tetrahydro-4-hydroxyphenylpyruvate => 3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51828", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391168", "l": "SIRP gamma binds CD47 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44059", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982017", "l": "Active G alpha (q) binds RGS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11139", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428750", "l": "Gq activation by TP receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102883", "l": "(+)-beta-chamigrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-beta-chamigrene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798044", "l": "BTG2 binds CCR4-NOT complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48460", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32456", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40217", "l": "FAD + H(+) + H2O2 => FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008029", "l": "pentraxin receptor activity", "d": ["Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625015", "l": "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20660", "l": "4-chlorophenylacetonitrile + 2 H2O <=> 4-chlorophenylacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033965", "l": "aculeacin-A deacylase activity", "d": ["Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37584", "l": "D-lysine + H2O + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65073", "l": "(2E,6E)-farnesyl diphosphate => dauca-4,7-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.17", "l": "\"lysozyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692749", "l": "CDC14A,B bind MAPK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48302", "l": "glycerol + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha 1-glyceryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015192", "l": "L-phenylalanine transmembrane transporter activity", "d": ["Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30285", "l": "(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+) => (-)-trans-permethrin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49450", "l": "alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose => beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11268", "l": "D-cysteine + H2O = H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.4.1.15", "l": "\"D-cysteine desulfhydrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799350", "l": "Exocytosis of specific granule membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24312", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.59", "l": "\"[cytochrome c]-lysine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678327", "l": "MIOX oxidises Ins to GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29484", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11215", "l": "indole + O2 <=> 2-formamidobenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12720", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39576", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40636", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57707", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57661", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047415", "l": "D-benzoylarginine-4-nitroanilide amidase activity", "d": ["Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H2O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691150", "l": "TFR2 dimer binds 2xholoTF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66055", "l": "indole-3-pyruvate + L-kynurenine <=> H2O + kynurenate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990028", "l": "intermediate voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871373", "l": "BMX phosphorylates RUFY1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57793", "l": "3,4-dinitrotoluene + NADH + O2 => 4-methyl-6-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.8", "l": "\"heparin-sulfate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0017168", "l": "5-oxoprolinase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12185", "l": "(S,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12749", "l": "3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.59", "l": "\"gallate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.12", "l": "\"T2-induced deoxynucleotide kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18381", "l": "dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate", "d": [], "t": []}, {"i": "EC:2.7.1.121", "l": "\"phosphoenolpyruvate--glycerone phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202717", "l": "Heterodimerization of CEACAMs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785181", "l": "LMF1,2 bind LIPC dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53508", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38516", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65304", "l": "2-oxoglutarate + O2 + verruculide A = chrodrimanin T + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190682", "l": "Connexin synthesis (generic) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66744", "l": "ATP + H2O + N-acetyl-L-aspartate(in) = ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31043", "l": "(S)-2-methyl-3-oxopropanoate + H2O + NAD(+) = 2 H(+) + methylmalonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32370", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20969", "l": "L-arabinonate => 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25095", "l": "ATP + dCMP => ADP + dCDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416929", "l": "PTGFR binds PGF2a (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41992", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30786", "l": "D-glyceraldehyde + H2O + NAD(+) <=> (R)-glycerate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700646", "l": "ASP-3026- resistant ALK mutants don't bind ASP-3026 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62301", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52051", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109813", "l": "GRB2-1 binds SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718360", "l": "GNRHR binds GNRHR peptide agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41667", "l": "dihydrochelirubine + NAD(+) <=> chelirubine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37839", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20963", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15547", "l": "acetate + pyruvate => (3S)-citramalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69328", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67080", "l": "a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41916", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784598", "l": "NPPA(124-151) binds NPR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36977", "l": "adenine + alpha-D-ribose 1,5-bisphosphate => AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58034", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45780", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30538", "l": "biotinate sulfoxide + H(+) + NADPH <=> biotin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10292", "l": "acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.4", "l": "\"glucosamine-phosphate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14691", "l": "3,4-dihydroxyphenylacetate + chloride + NAD(+) => 4-chlorophenylacetate + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15558", "l": "ATP + H2O + Ni(2+)(out) => ADP + H(+) + Ni(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676229", "l": "WIPIs bind PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17673", "l": "quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.76", "l": "\"quercetin 3-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029272", "l": "Release of PLCG from FCGR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75881", "l": "methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline => Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005009", "l": "insulin receptor activity", "d": ["Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}, {"i": "REACT:R-HSA-74715", "l": "Autophosphorylation of insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27719", "l": "H2O + IMP => inosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9623384", "l": "α1-agonists bind ADRA1A,B,D (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20301", "l": "ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": [], "t": []}, {"i": "EC:6.1.1.19", "l": "\"arginine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198714", "l": "ERK5 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23165", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose => a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33502", "l": "H(+) + prephenate <=> 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.2", "l": "\"(S)-2-haloacid dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56468", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.57", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755354", "l": "8 forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140775", "l": "actin filament debranching activity", "d": ["Binding to an actin filament and promoting the dissociation of an actin filament branch."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35416", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose => an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226999", "l": "ADD1:ADD3 binds DMTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210300", "l": "Interaction of DAP12 and TREM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676133", "l": "CD74 binds MIF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015271", "l": "outward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0009881", "l": "photoreceptor activity", "d": ["The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70068", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11296", "l": "2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.26", "l": "\"2,5-dioxovalerate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14926", "l": "D-mannitol 1-phosphate + NADP(+) => D-mannose 6-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835358", "l": "p-TARBP2 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41680", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050454", "l": "coenzyme F420 hydrogenase activity", "d": ["Catalysis of the reaction: coenzyme F420 + H(2) + H+ = reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836993", "l": "GRSF1 binds RNA containing quadruplex guanosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21350", "l": "10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2 => 8 H(+) + 10 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18491", "l": "carbamate + CO2 => cyanate + H(+) + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570528", "l": "SUMOylation of XPC with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430190", "l": "p-SLP-76 binds NCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14872", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043472", "l": "IgD binding", "d": ["Binding to an immunoglobulin of a D isotype."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35828", "l": "H2O + N(1)-aminopropylagmatine => spermidine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043905", "l": "L-seryl-tRNA(Thr) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50825", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673288", "l": "ppDVL binds RAC1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76065", "l": "3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in) => 3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31446", "l": "ATP + D-sedoheptulose 7-phosphate <=> ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805792", "l": "p-S291-PHF20 translocates to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44756", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000433", "l": "SUMOylation of PML with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070463", "l": "tubulin-dependent ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379992", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30369", "l": "adenosylcob(III)alamin + phosphate => adenosylcob(III)alamin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71075", "l": "L-arginine(in) + L-cystine(out) = L-arginine(out) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.72", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23928", "l": "H2O + N(8)-acetylspermidine = acetate + spermidine", "d": [], "t": []}, {"i": "EC:3.5.1.48", "l": "\"acetylspermidine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606349", "l": "Mis18 complex binds the centromere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785711", "l": "Telomere shortening during replicative exhaustion (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25664", "l": "alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20096", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21538", "l": "3-methyl-(2E)-glutaconyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52863", "l": "a short-chain fatty acid + ATP + CoA <=> a short-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592371", "l": "Initial activation of proMMP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11918", "l": "15-oxoprostaglandin E2 + H(+) + NADH => 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0055056", "l": "D-glucose transmembrane transporter activity", "d": ["Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37280", "l": "ATP + H2O + L-alanyl-L-histidine(out) => ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10538", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67750", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24978", "l": "(1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58777", "l": "NADP(+) + pyridine 3-methanol => H(+) + NADPH + pyridine-3-carbaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32467", "l": "2 S-adenosyl-L-methionine + sarcosine = glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.157", "l": "\"sarcosine/dimethylglycine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13160", "l": "(R)-glycerate + CO2 + NADP(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57895", "l": "a quinone + 5 H(+)(in) + NADPH <=> a quinol + 4 H(+)(out) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855375", "l": "PTPN22 dissociates from CSK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67130", "l": "(1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+) => 5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28093", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005154", "l": "epidermal growth factor receptor binding", "d": ["Binding to an epidermal growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0015616", "l": "DNA translocase activity", "d": ["Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204311", "l": "AOX1 oxidises PXL to PDXate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375131", "l": "Basigin binds CD98 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517705", "l": "p-S318,221-HuR binds mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55167", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 <=> H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028819", "l": "VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615249", "l": "ARBs bind AGRT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351948", "l": "Mitochondrial recruitment of Drp1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008126", "l": "acetylesterase activity", "d": ["Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59771", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428262", "l": "ACER3 hydrolyzes phytoceramide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16272", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) <=> 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69170", "l": "2 H(+) + N-(2-carboxyethyl)spermidine + NADH => H2O + NAD(+) + spermine monoaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58538", "l": "CoA + H(+) + N-hexadecanoylglycine => glycine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615348", "l": "AGT(34-41) binds to AGTR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31737", "l": "3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 3-oxocholan-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373734", "l": "Nephrin interacts with Podocin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390402", "l": "Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12293", "l": "ATP + L-serine + tRNA(Ser) => AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32389", "l": "dihydrocarvone + H(+) + NADH => dihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709842", "l": "MAVS binds TOMM70 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32314", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34216", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) => 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050241", "l": "pyrroline-2-carboxylate reductase activity", "d": ["Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626681", "l": "Recruitment of transition zone proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48101", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61262", "l": "2-oxoglutaramate + H2O2 + NH4(+) => H2O + L-glutamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018634", "l": "alpha-pinene monooxygenase [NADH] activity", "d": ["Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52274", "l": "gramine + H(+) + S-adenosyl-L-homocysteine => (1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56053", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731931", "l": "EDNRA binds selective ERAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022882", "l": "protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41191", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0047952", "l": "glycerol-3-phosphate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46371", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38226", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol <=> 1-O-decyl-(9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40331", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102766", "l": "naringenin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine = sakuranetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050589", "l": "leucocyanidin oxygenase activity", "d": ["Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.55", "l": "\"caspase-2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17408", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine <=> H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374662", "l": "Translocation of Ezrin to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72073", "l": "H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide => L-histidyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45673", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635854", "l": "GLI2,3 are degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76619", "l": "(6E)-8-methylnon-6-enoyl-CoA + 4-hydroxy-3-methoxy-benzenemethanol = capsiate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161282", "l": "Elastic fibres bind associated proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018798", "l": "RHOV binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32585", "l": "6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46587", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68326", "l": "1D-myo-inositol 2-phosphate + phosphate => 1D-myo-inositol 2,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687081", "l": "MAPK6 is ubiquitinated at the N-terminal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609310", "l": "β-blockers bind ADRB1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48490", "l": "all-trans-retinal--[retinol-binding protein] + H(+) + NADH => all-trans-retinol--[retinol-binding protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850534", "l": "PDCL promotes G-protein beta 5 folding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41923", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617848", "l": "CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46294", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65131", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36492", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77745", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a triacylglycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51881", "l": "3,4,6-trichlorocatechol + O2 => (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14673", "l": "a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611839", "l": "β3-agonists bind ADRB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50173", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854222", "l": "TBC1D3 associates with RAB5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11627", "l": "2-(hydroxyimino)propanoate + acetone <=> acetone oxime + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0019113", "l": "limonene monooxygenase activity", "d": ["Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41472", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.123", "l": "\"oryzalexin D synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391934", "l": "DP2 receptor can bind PGD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35999", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45710", "l": "3-dehydrocarnityl-CoA + acetate => 3-dehydrocarnitine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26247", "l": "diphosphate + fusicocca-2,10(14)-diene => geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44036", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O = 12,13-dihydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41640", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.41", "l": "\"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64153", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77310", "l": "N(omega),N('omega)-dimethyl-L-arginine + pyruvate <=> 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69957", "l": "Ca(2+)(out) + 3 Na(+)(in) => Ca(2+)(in) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71136", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) => H(+)(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198314", "l": "DAG stimulates protein kinase C-delta (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709878", "l": "BIL translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72903", "l": "butyrolactone II + dimethylallyl diphosphate = butyrolactone I + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981610", "l": "Neuroglobin binds oxygen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75559", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] = cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047732", "l": "CDP-abequose epimerase activity", "d": ["Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69719", "l": "(indol-3-yl)acetate + ATP + H(+) = (indol-3-yl)acetyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052627", "l": "vanillate amino acid synthetase activity", "d": ["Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226979", "l": "ADD1:ADD2 binds DMTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70759", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68354", "l": "3',2'-cGAMP + diphosphate => pppA(2'-5')pG", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38846", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44444", "l": "a 1,2-diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395764", "l": "atREs binds to nascent CM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10617", "l": "(2R,3S)-catechin + H2O + NADP(+) => (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40535", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25683", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114256", "l": "CYCS:APAF1 binds procaspase-9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48820", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449087", "l": "CD4 binds Interleukin-16 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982765", "l": "Growth hormone forms dimers and oligomers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947531", "l": "Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66531", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36971", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": [], "t": []}, {"i": "EC:5.1.3.27", "l": "\"dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23852", "l": "catechol + O2 = cis,cis-muconate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.1", "l": "\"catechol 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60822", "l": "adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14214", "l": "ATP + beta-D-fructose 1-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53748", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71783", "l": "MDH2 reduces OA to MAL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38361", "l": "thiosulfate + ubiquinol-10 => 2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67737", "l": "N-acetyl-alpha-neuraminate => aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40326", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19389", "l": "(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849102", "l": "SRMS phosphorylates PTK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30984", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.41", "l": "\"complement subcomponent C1r\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760399", "l": "ILF3 and HOXC8 bind CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052604", "l": "delta-tocopherol cyclase activity", "d": ["Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24607", "l": "7-methylxanthine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180000", "l": "histone methyltransferase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a histone methyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9005980", "l": "IL21 binds IL21R:JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2219524", "l": "PDPK1 binds PIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684140", "l": "ATM phosphorylates RBBP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675947", "l": "TNFSF18 binds TNFRSF18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45967", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O <=> 2 AMP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351871", "l": "Caspase-mediated cleavage of Z0-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070539", "l": "linoleic acid binding", "d": ["Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11764", "l": "H2O + methylguanidine = methylamine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.16", "l": "\"methylguanidinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15766", "l": "adenosylcob(III)inamide + GTP => adenosylcob(III)inamide phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392752", "l": "Phosphorylation of L1 by CK-II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52410", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-phospho-D-erythronate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167111", "l": "Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70064", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140319", "l": "receptor decoy activity", "d": ["Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48451", "l": "a ganglioside GA2 + H2O <=> a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75418", "l": "H2O + N-methylmyosmine <=> pseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49297", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59647", "l": "D-xylobiono-1,5-lactone + H2O <=> D-xylobionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093327", "l": "EPHA binds TIAM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69429", "l": "arsenite + 3 glutathione + H(+) => arsenic triglutathione + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.64", "l": "\"caspase-11\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30871", "l": "2-deoxy-D-ribose + ATP = 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.229", "l": "\"deoxyribokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939667", "l": "ITGA5 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200396", "l": "Creatine transport across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63940", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017118", "l": "lipoyltransferase activity", "d": ["Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N6-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H+."], "t": []}, {"i": "RHEA:20473", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043960", "l": "L-erythro-3-methylmalyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26115", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + epi-cedrol", "d": [], "t": []}, {"i": "EC:4.2.3.39", "l": "\"epi-cedrol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66672", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) = 5,7-dihydroxy-4-methylphthalide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68236", "l": "L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41330", "l": "(12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69551", "l": "H(+) + O-phospho-L-serine <=> CO2 + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090624", "l": "endoribonuclease activity, cleaving miRNA-paired mRNA", "d": ["Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102483", "l": "scopolin beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + scopolin = beta-D-glucose + scopoletin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990135", "l": "flavonoid sulfotransferase activity", "d": ["Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050123", "l": "N-acylmannosamine 1-dehydrogenase activity", "d": ["Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665989", "l": "DIAPH1 binds RHOA:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022141", "l": "Prolysyl oxidase activation (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19712", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75236", "l": "L-fucono-1,5-lactone => L-fucono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696183", "l": "AOC3 deaminates BZAM (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51885", "l": "L-proline betaine => D-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42369", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42875", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23910", "l": "2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine => H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45310", "l": "11beta-prostaglandin F2-ethanolamide + NADP(+) => H(+) + NADPH + prostaglandin D2-ethanolamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58040", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033418", "l": "CUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUC codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411373", "l": "NLK translocates to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53209", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67281", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619367", "l": "CaMKKs phosphorylate CAMK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22331", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55564", "l": "4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008388", "l": "testosterone 15-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57015", "l": "a menaquinone + H2O + sulfite <=> a menaquinol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050205", "l": "oxamate carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947531", "l": "Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50631", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 3-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60215", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67611", "l": "H2O + N(6)-methyl-ATP <=> diphosphate + H(+) + N(6)-methyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33271", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37082", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20723", "l": "H2O + isopenicillin N + phenylacetyl-CoA <=> CoA + H(+) + L-2-aminoadipate + penicillin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75888", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] => ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350578", "l": "NQO1 interaction with ODC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20214", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12953", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64834", "l": "3-hydroxy-benzyl benzoate + CoA => 3-hydroxybenzyl alcohol + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51589", "l": "isopyridoxal + NAD(+) => 5-pyridoxolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66631", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 <=> (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.5", "l": "\"dynamin GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950778", "l": "p-Y693-STAT4 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59575", "l": "H2O + L-homocarnosine <=> 4-aminobutanoate + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43399", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20575", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140769", "l": "factor VII -> factor VIIa (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832845", "l": "Expression of ZEB2 in neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58100", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O = (15Z)-tetracosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084912", "l": "Arresten binds integrin alpha1beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42327", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74986", "l": "Elongation of pre-rRNA transcript (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35994", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21016", "l": "H2O + L-asparagine = L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373711", "l": "DCC interaction with Netrin-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74045", "l": "L-alanine(out) + L-methionine(in) => L-alanine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37701", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29233", "l": "cyanate(out) => cyanate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43411", "l": "sphinganine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63561", "l": "angiotensin I + H2O => angiotensin II + L-histidyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870703", "l": "SOD2 (MnSOD) gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976801", "l": "Complement factor I complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52217", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O => [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62082", "l": "6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-sulfate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662818", "l": "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062060", "l": "NuA4 histone acetyltransferase complex binding", "d": ["Binding to a NuA4 histone acetyltransferase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007447", "l": "E2F6 forms the PRC1L4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17459", "l": "[sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine => [sulfur-carrier protein]-L-cysteine + L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691154", "l": "HFE binds TFRC dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358919", "l": "MSH2:MSH3 exchanges ADP for ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944262", "l": "Association of procollagen type X (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688797", "l": "ATXN3 family cleave Ub chains (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19991", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45141", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O => CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46408", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001070", "l": "starch binding", "d": ["Binding to starch."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59478", "l": "2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol => 2 AH2 + 2 ATP + benzoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54056", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.174", "l": "\"(2E,6E)-hedycaryol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70507", "l": "dimethylallyl diphosphate + H2O = dimethylallyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35850", "l": "ATP + sphing-4-enine <=> ADP + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63099", "l": "ilicicolin A epoxide <=> ilicicolin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76099", "l": "a dicarboxylate(in) + xanthurenate(out) = a dicarboxylate(out) + xanthurenate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51997", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17000", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol <=> 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20052", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627104", "l": "XIAP binds CASP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59632", "l": "D-xylobiose + O2 = D-xylobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24641", "l": "ergosteryl 3-beta-D-glucoside + H2O => D-glucose + ergosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71806", "l": "acetate(out) + H(+)(out) <=> acetate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24454", "l": "[protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine => L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75495", "l": "n H(+)(out) + pregnenolone sulfate(out) = n H(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22989", "l": "3-oxopropanoate + CoA + NADP(+) => acetyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733292", "l": "AMY1-3 bind pramlintide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52420", "l": "O-phospho-L-serine + thiosulfate = phosphate + S-sulfo-L-cysteine", "d": [], "t": []}, {"i": "EC:2.8.5.1", "l": "\"S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29002", "l": "H(+)(out) + homoserine lactone(in) <=> H(+)(in) + homoserine lactone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351207", "l": "Spermine  => N-acetylated spermine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033815", "l": "biphenyl synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538900", "l": "Phosphorylated PER rebinds to phosphorylated TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032866", "l": "D-xylose:NADP reductase activity", "d": ["Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68361", "l": "L-xylono-1,4-lactone + O2 => dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56830", "l": "2,3,5,6-tetrachlorohydroquinone + 2 glutathione => 2,3,6-trichlorohydroquinone + chloride + glutathione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336421", "l": "DT fragment A ADP-ribosylates target cell EEF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58681", "l": "A + FADH2 => AH2 + FAD + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11526", "l": "cholest-4-en-3-one + H(+) + NADPH => 5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450422", "l": "KSRP recruits RNA degradation activities (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49314", "l": "2-trans-(+)-abscisic aldehyde + H(+) + NADH => 2-trans,4-trans-xanthoxin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602454", "l": "proMMP9 binds TIMP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033780", "l": "taurochenodeoxycholate 6alpha-hydroxylase activity", "d": ["Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25767", "l": "3-carboxy-2-oxobutanoate + H(+) = 2-oxobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18230", "l": "glycolate + NAD(+) => glyoxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56265", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30294", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33909", "l": "4-aminobutanoate + formaldehyde + H2O2 => 4-(methylamino)butanoate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51447", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39092", "l": "(2E)-decenedioyl-CoA + H2O => (3S)-hydroxydecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018422", "l": "GDP-mannose:serine-protein mannose-1-phosphotransferase activity", "d": ["Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799097", "l": "ATM phosphorylates ZNF420 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14396", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193703", "l": "IKKbeta is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61941", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034570", "l": "hydroxymonomethylisoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51593", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene => benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23652", "l": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": [], "t": []}, {"i": "EC:2.3.2.5", "l": "\"glutaminyl-peptide cyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59783", "l": "L-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848751", "l": "PTK6 binds AKT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23772", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.58", "l": "\"2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675473", "l": "SH2B binds JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72436", "l": "(E)-caffeoyl-AMP + CoA => (E)-caffeoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65221", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11523", "l": "(-)-menthol + UDP-alpha-D-glucose <=> (-)-menthyl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27775", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112430", "l": "Formation of P-TEFb complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68607", "l": "(2S)-3-sulfopropanediol <=> H(+) + hydroxyacetone + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69886", "l": "L-ascorbate(out) + 2 Na(+)(out) <=> L-ascorbate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46112", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0008320", "l": "protein transmembrane transporter activity", "d": ["Enables the transfer of a protein from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033707", "l": "3''-deamino-3''-oxonicotianamine reductase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15025", "l": "S-adenosyl-L-methionine + xanthosine = 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.158", "l": "\"7-methylxanthosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74911", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16183", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37536", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102759", "l": "campestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + campestanol + O2 + NADPH = 6-deoxycathasterone + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15798", "l": "bilirubin IXalpha + NAD(+) => biliverdin IXalpha + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37787", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928604", "l": "SFKs phosphorylate VAV2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10965", "l": "ATP + D-xylulose => ADP + D-xylulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28931", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate", "d": [], "t": []}, {"i": "EC:5.3.2.8", "l": "\"4-oxalomesaconate tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49038", "l": "(-)-bursehernin + H(+) + S-adenosyl-L-homocysteine => (-)-pluviatolide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47121", "l": "docosanoate + glycine => H2O + N-docosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68093", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34009", "l": "5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine => 7-dehydrodesmosterol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106436", "l": "glutathione-dependent sulfide quinone oxidoreductase activity", "d": ["Catalysis of the reaction: a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202534", "l": "Ubiquitination of NEMO by TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12964", "l": "acetoacetate + butanoyl-CoA <=> acetoacetyl-CoA + butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815529", "l": "nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28673", "l": "2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.297", "l": "\"limonene-1,2-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50977", "l": "prostaglandin D2(out) => prostaglandin D2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36357", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052826", "l": "inositol hexakisphosphate 2-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662610", "l": "MT1B binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77049", "l": "4-phenylbutan-2-one + H(+) + NADH + NH4(+) => 4-phenylbutan-2-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754537", "l": "SARS-CoV-2 3a tetramer binds to VPS39 within HOPS complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22974", "l": "butanoyl-CoA + H(+) + NADPH => butanal + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.007505823603481", "identifiers": [{"i": "GO:0016801", "l": "hydrolase activity, acting on ether bonds", "d": ["Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively."], "t": []}, {"i": "EC:3.3.-.-", "l": "\"Acting on ether bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40154", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77368", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + CMP-N-acetyl-beta-neuraminate => [N-acetyl-alpha-D-neuraminosyl-(2->8)](n+1) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730862", "l": "Autophosphorylation of LYN kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16935", "l": "2-oxobutanoate + NH4(+) => 1-aminocyclopropane-1-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38546", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] <=> (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220981", "l": "NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56609", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O => L-serine + tetrahydrosulfopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70899", "l": "histidine => urocanate + NH4+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62368", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58516", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25392", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) => cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052751", "l": "GDP-mannose hydrolase activity", "d": ["Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114558", "l": "Thrombin-activated PARs activate Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34411", "l": "cannabigerolate + O2 = cannabidiolate + H2O2", "d": [], "t": []}, {"i": "EC:1.21.3.8", "l": "\"cannabidiolic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71164", "l": "homogentisate + O2 => maleylacetoacetate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977301", "l": "Histidine is decarboxylated to histamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15656", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69555", "l": "dihydroxyacetone phosphate + L-glutamate <=> (S)-serinol phosphate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66421", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20267", "l": "cis-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20202", "l": "ATP + H2O + L-phenylalanine => AMP + D-phenylalanine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803892", "l": "SFN dimer binds BAX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37947", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12399", "l": "dTDP-D-galactose + H2O + 2 NADP(+) <=> dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102874", "l": "1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49187", "l": "chlorophyllide a + H(+) + H2O <=> 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222376", "l": "NOX2 generates superoxide from oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22888", "l": "(R)-methylmalonyl-CoA = succinyl-CoA", "d": [], "t": []}, {"i": "EC:5.4.99.2", "l": "\"methylmalonyl-CoA mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25820", "l": "H2O + O2 + spermidine = 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66081", "l": "2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54204", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11500", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.45", "l": "\"3-deoxy-manno-octulosonate-8-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202307", "l": "Change of PKC theta conformation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53762", "l": "allocholoyl-CoA + deoxycholate => allocholate + deoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28488", "l": "Fe(2+)(out) => Fe(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63176", "l": "(2S)-ibuprofenoyl-CoA = (2R)-ibuprofenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12423", "l": "ATP + D-tagatofuranose 6-phosphate <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015432", "l": "ABC-type bile acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203979", "l": "Coat Assembly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139898", "l": "Caspase-8 activates BID by cleavage (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75186", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + lydicene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013159", "l": "CDC42 GEFs activate CDC42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617595", "l": "SGTA binds mislocalized membrane protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12819", "l": "biochanin A + 2 H(+) + NADPH => 2,3-dihydrobiochanin A + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350410", "l": "RHO1:GDP complex dissociates from RHOGAPP190 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429157", "l": "ABCC4 accumulation of dense granule contents (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0070008", "l": "serine-type exopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802922", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160874", "l": "HYAL1 hydrolyses (HA)50 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20439", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH => 5D-5-O-methyl-chiro-inositol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.313", "l": "\"25S rRNA (uracil(2634)-N(3))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49076", "l": "dibenzothiophene + FMNH2 + O2 = dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54274", "l": "(3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794444", "l": "ALB binds Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17772", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250264", "l": "TXNIP binds reduced thioredoxin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141437", "l": "Formation of the MCC complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39110", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22255", "l": "a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41741", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028820", "l": "Formation of VAF (virus-activated factor) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004460", "l": "L-lactate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371582", "l": "HSBP1 binds HSF1 trimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65850", "l": "a steroid 1,3-dione + AH2 => A + a 3-oxo-Delta(1)-steroid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18500", "l": "L-ribulose 5-phosphate <=> L-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54186", "l": "a carboxylate + an aromatic L-alpha-amino acid => an N-acyl-aromatic L-alpha-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38877", "l": "pseudouridine(2604) in 23S rRNA => uridine(2604) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976817", "l": "Formation of serum amyloid P decamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140825", "l": "lactoperoxidase activity", "d": ["Catalysis of the reaction: 2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52648", "l": "H2O + L-arabino-1,4-lactone 5-phosphate = 5-phospho-L-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23574", "l": "3 CO2 + 4 CoA + phlorisovalerophenone => 3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474210", "l": "Collagen type III degradation by MMP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23314", "l": "1(F)-beta-D-fructosylsucrose + D-glucose => 2 sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416929", "l": "PTGFR binds PGF2a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77413", "l": "(2S)-2-hydroxybut-3-enenitrile => acrolein + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951695", "l": "TEADs:YAP1 binds CTGF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35990", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797554", "l": "ABP1 binds SHANK proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731924", "l": "EDNRA binds EDNs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25620", "l": "terpentedienyl diphosphate <=> diphosphate + terpentetriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61108", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726621", "l": "PGR binds PGR antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199456", "l": "PTEN dephosphorylates PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25806", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65592", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28362", "l": "dGTP + H2O = dGMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69608", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17378", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] => 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681294", "l": "IL6R binds IL6R inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21077", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => CO2 + succinate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53933", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30030", "l": "D-glyceraldehyde + H(+) + NADH <=> glycerol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67582", "l": "adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate => 3'-phosphoadenylyl sulfate + tauro-alpha-muricholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176452", "l": "Degradation of ubiquitinated SMAD2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15284", "l": "lathosterol <=> 5alpha-cholest-8-en-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196773", "l": "COASY phosphorylates DP-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34139", "l": "Delta(9)-tetrahydrocannabinolate + H(+) = CO2 + Delta(9)-tetrahydrocannabinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14798", "l": "2-dehydro-3-deoxy-D-gluconate + ATP => 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19194", "l": "A + all-trans-13,14-dihydroretinol => AH2 + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395784", "l": "Nascent CMs transform into mature CMs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62037", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39949", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,3-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005464", "l": "UDP-xylose transmembrane transporter activity", "d": ["Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate."], "t": []}, {"i": "REACT:R-HSA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64485", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA => 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983011", "l": "Expression of STAT5 upregulated genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49585", "l": "D-erythrulose 1-phosphate => L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76665", "l": "2 H(+) + NADPH + pentanoate => H2O + NADP(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46702", "l": "(R)-lipoyl-GMP + diphosphate => (R)-lipoate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19736", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) <=> bacteriochlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086083", "l": "cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication", "d": ["Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45916", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350604", "l": "Agmatine + H2O <=> putrescine + urea (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57871", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 <=> (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49893", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0032552", "l": "deoxyribonucleotide binding", "d": ["Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382096", "l": "Formation of NR-NCOR Corepressor Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015183", "l": "L-aspartate transmembrane transporter activity", "d": ["Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39858", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69987", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) = (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49360", "l": "2',2'-dihydroxy-2-oxospirilloxanthin = 2,2'-dioxospirilloxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46667", "l": "corticosterone + H(+) + NADPH <=> 5beta-dihydrocorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016847", "l": "1-aminocyclopropane-1-carboxylate synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132133", "l": "C5b:C6:C7 inserts into the target cell membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23837", "l": "D-methionine + pyruvate => 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39958", "l": "(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45205", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol => H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28387", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28862", "l": "Ag(+)(in) + H(+)(in) <=> Ag(+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730903", "l": "Oligomerization of TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140083", "l": "ATP-dependent protein-DNA unloader activity", "d": ["Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49267", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O <=> (E)-caffeate + H(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20380", "l": "androsterone + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18106", "l": "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1671687", "l": "PRLR activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17074", "l": "acetyl-CoA + cortisol => CoA + cortisol 21-acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042279", "l": "nitrite reductase (cytochrome, ammonia-forming) activity", "d": ["Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018670", "l": "4-aminobenzoate 1-monooxygenase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35928", "l": "paromamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32727", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.199", "l": "\"very-long-chain 3-oxoacyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68712", "l": "(2E,6E)-farnesyl diphosphate = (1S,2S,4R)-beta-elemene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392195", "l": "Gi activation by P2Y purinoceptor 12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51544", "l": "D-ribulose = D-xylulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62918", "l": "an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913374", "l": "Phosphorylated SHC1 recruits SHIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64639", "l": "benzoyl-CoA + butan-1-ol <=> butyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36697", "l": "desmethyldescarbamoylnovobiocin + dTDP + H(+) => dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19278", "l": "ATP + L-pyrrolysine + tRNA(Pyl) => AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34734", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35359", "l": "3-hydroxyisoheptadecanoyl-CoA = (2E)-15-methylhexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46563", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65823", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49746", "l": "CO2 + deoxyviolacein + H2O => deoxyviolaceinate + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018678", "l": "4-hydroxybenzoate 1-hydroxylase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56425", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43673", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10258", "l": "[(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675790", "l": "MTORC1 dissociates from ULK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41304", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50574", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018742", "l": "epoxide hydrolase B activity", "d": ["Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30971", "l": "7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene", "d": [], "t": []}, {"i": "EC:5.2.1.13", "l": "\"prolycopene isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72865", "l": "G[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730862", "l": "Autophosphorylation of LYN kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69978", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40337", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37606", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018754", "l": "GDIs bind RHOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37052", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68162", "l": "H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21332", "l": "acetyl-CoA + D-glucosamine = CoA + H(+) + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.3.1.3", "l": "\"glucosamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18080", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) <=> H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.178", "l": "\"2-dehydro-3-deoxyglucono/galactono-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050156", "l": "ornithine N-benzoyltransferase activity", "d": ["Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70949", "l": "L-tryptophan(out) => L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10135", "l": "ATP + benzoate + CoA <=> AMP + benzoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53278", "l": "17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662613", "l": "MT3 exchanges zinc for copper (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73216", "l": "sulfate(out) + thiosulfate(in) => sulfate(in) + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004963", "l": "follicle-stimulating hormone receptor activity", "d": ["Combining with follicle-stimulating hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55019", "l": "H(+) + menthone + NADPH + O2 <=> 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173723", "l": "C8 binds C5b:C6:C7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791130", "l": "Expression of CTDSP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64127", "l": "H2O + N-hexadecanoyl-L-phenylalanine <=> hexadecanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67055", "l": "AH2 + asnovolin J + O2 <=> A + asnovolin A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58270", "l": "[protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide => [protein]-C-terminal glycine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48905", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820842", "l": "AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19183", "l": "a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57121", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047268", "l": "galactinol-raffinose galactosyltransferase activity", "d": ["Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64096", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] = 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236947", "l": "Egress of internalized antigen to the cytosol via sec61 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015446", "l": "ATPase-coupled arsenite transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25731", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21545", "l": "(2E,6E)-farnesyl diphosphate + ATP => (2E,6E)-farnesyl triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66985", "l": "3-methylbutanoyl-CoA + H2O => 3-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75321", "l": "chloride(in) + D-alanine(in) + 2 Na(+)(in) => chloride(out) + D-alanine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250930", "l": "B-WICH recruits histone acetyltransferases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17312", "l": "a phenyl acetate + H2O <=> a phenol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730835", "l": "Autophosphorylation of PKC-theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77124", "l": "1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,2,3-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388809", "l": "CTLA-4 binds B7-1/B7-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63516", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 = biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72630", "l": "2 H(+)(out) + Zn(2+)(in) <=> 2 H(+)(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18635", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate => 2 ATP + H2O + hydrogencarbonate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44888", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19708", "l": "CoA + hexadecanal + NAD(+) <=> H(+) + hexadecanoyl-CoA + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696564", "l": "USP25 deubiquitinates DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18513", "l": "D-mannitol + O2 = D-mannose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48004", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75108", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47923", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O <=> ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16896", "l": "pyridine + S-adenosyl-L-methionine <=> N-methylpyridinium + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140700", "l": "3',2'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944255", "l": "Association of procollagen type VII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36035", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659820", "l": "RB1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668831", "l": "CST complex formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727857", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10171", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871227", "l": "RET binds GFRA4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13675", "l": "[protein-PII]-uridylyl-L-tyrosine + diphosphate => [protein-PII]-L-tyrosine + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024723", "l": "EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30717", "l": "(S)-linalool => (2E)-geraniol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57629", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate => H2O + ML-236C carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72985", "l": "6-(3-dimethylallyl)harmol + diphosphate => dimethylallyl diphosphate + harmol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790038", "l": "Expression of HSP90B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23085", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58371", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) <=> (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42016", "l": "cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31069", "l": "Delta(1)-piperideine-2-carboxylate + H2O => 6-amino-2-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19738", "l": "4-(gamma-L-glutamylamino)butanoate + H2O => 4-aminobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57161", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31152", "l": "H2O + L-selenocystathionine => 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65885", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => H2O + L-glutamate + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62481", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047427", "l": "cyanoalanine nitrilase activity", "d": ["Catalysis of the reaction: 3-cyano-L-alanine + 2 H2O + H+ = L-aspartate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3221982", "l": "BANP binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44810", "l": "2-demethylmenaquinol-10 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43716", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP", "d": [], "t": []}, {"i": "EC:2.7.7.89", "l": "\"[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74893", "l": "CO2(in) => CO2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30068", "l": "betaine aldehyde + H2O + NADP(+) => glycine betaine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030367", "l": "interleukin-17 receptor binding", "d": ["Binding to an interleukin-17 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.120", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156678", "l": "Activation of Cdc25C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19380", "l": "NADP(+) + reduced riboflavin <=> 2 H(+) + NADPH + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071859", "l": "neuropeptide F receptor binding", "d": ["Binding to a neuropeptide F receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29699", "l": "dimethyl sulfoxide(in) = dimethyl sulfoxide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.154", "l": "\"corrinoid adenosyltransferase EutT\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004015", "l": "adenosylmethionine-8-amino-7-oxononanoate transaminase activity", "d": ["Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60858", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9669893", "l": "KIT binds type I TKIs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65763", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004850", "l": "uridine phosphorylase activity", "d": ["Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11798", "l": "3-dehydroecdysone + H2O2 => ecdysone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647631", "l": "GSDMD (1-275) binds PIPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19331", "l": "H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP => nuatigenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806957", "l": "MET receptor dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41802", "l": "3-oxobutanoyl-[ACP] + CO2 + holo-[ACP] => acetyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804383", "l": "PRMT5 methylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16803", "l": "adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein] => 3'-phosphoadenylyl sulfate + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17598", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] => D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13943", "l": "ADP + D-glyceraldehyde 3-phosphate + H(+) => ATP + D-glyceraldehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48646", "l": "(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde => prostaglandin H2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50218", "l": "(8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35405", "l": "(3R)-vestitone + H(+) + NADPH => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.125", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20904", "l": "(S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21066", "l": "[protein]-dithiol + glutathione disulfide => [protein]-disulfide + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201603", "l": "Caspase-mediated cleavage of PKC theta (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29026", "l": "H(+)(in) + L-fucose(in) <=> H(+)(out) + L-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36864", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69868", "l": "a uridine in RNA + S-adenosyl-L-methionine => a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11715", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052771", "l": "coenzyme F390-G hydrolase activity", "d": ["Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76278", "l": "Na(+)(out) + uracil(out) <=> Na(+)(in) + uracil(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939201", "l": "ESR dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47538", "l": "isochenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17544", "l": "an aromatic primary alcohol + O2 <=> an aromatic aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212356", "l": "Formation of CSL-NICD coactivator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63326", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.6", "l": "\"farnesylcysteine lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009072", "l": "STAT3 phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62278", "l": "6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine => 3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023461", "l": "MECP2 T158A:SIN3A complex does not bind BDNF gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009936", "l": "RNASEL cleaves cellular ssRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18350", "l": "ATP + L-aspartate + tRNA(Asx) => AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16824", "l": "6-phospho-D-gluconate + NAD(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851131", "l": "NPM1-ALK-stimulated PRF1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938034", "l": "NR4A3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30590", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide <=> 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70055", "l": "AH2 + cremeomycin = 2-hydroxy-4-methoxybenzoate + A + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72645", "l": "1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678981", "l": "TLR9 processing at neutral pH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112437", "l": "Formation of NELF complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14289", "l": "a dicarboxylate + ATP + CoA = AMP + diphosphate + omega-dicarboxyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.23", "l": "\"dicarboxylate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32814", "l": "benzoate(in) <=> benzoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655193", "l": "KIAA0101 double monoubiquitination (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55178", "l": "2-hydroxybutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + butanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047304", "l": "2-aminoethylphosphonate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47418", "l": "a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+) => an NDP-alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68930", "l": "AMP + diphosphate + heptanal + NADP(+) => ATP + H(+) + heptanoate + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69993", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH => 3-dehydro-6-deoxoteasterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23973", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) => (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37061", "l": "AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA => adenosine(37) in tRNA + L-threonylcarbamoyladenylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632386", "l": "TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39700", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA => (2E,13Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981539", "l": "C3b binds to cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58217", "l": "A + dihydroserpentine => AH2 + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17328", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA <=> (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545196", "l": "FN1 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090655", "l": "double-stranded/single-stranded junction telomeric DNA binding", "d": ["Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391933", "l": "EP3 receptor can bind PGE2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354077", "l": "Integrin alphaIIb beta3 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18051", "l": "L-glutamate + N-acetyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-acetyl-L-ornithine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018586", "l": "mono-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559439", "l": "CD14:LPS binds CR3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49989", "l": "acetone + H(+) + NADPH + O2 => H2O + methyl acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37417", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67773", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O => a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936963", "l": "IRAK2 induces TRAF6 oligomerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16761", "l": "chlorohydroquinone + O2 = 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33646", "l": "(9Z)-tetradecenoate + ATP + CoA <=> (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70893", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(in) => L-asparagine(out) + L-glutamine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66458", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32883", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) = (+)-artemisinic aldehyde + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.92", "l": "\"artemisinic aldehyde Delta(11(13)) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24106", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine => 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209227", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16442", "l": "H2O + L-glutaminyl-[protein] => L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41978", "l": "a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+) => a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37797", "l": "2 H2O + 2 NADP(+) => 2 H(+) + 2 NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45212", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) = CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}, {"i": "EC:2.3.1.169", "l": "\"CO-methylating acetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66303", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62584", "l": "ATP + H2O + L-tyrosine(out) = ADP + H(+) + L-tyrosine(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.13", "l": "\"ABC-type tyrosine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58230", "l": "H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide => L-asparaginyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177284", "l": "PKA phosphorylates PDE4B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14320", "l": "morphine + NAD(+) <=> H(+) + morphinone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48439", "l": "H2O + pentanoate ester <=> an aliphatic alcohol + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11182", "l": "AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) => ATP + L-asparagine + tRNA(Asn)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31698", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036189", "l": "abieta-7,13-diene hydroxylase activity", "d": ["Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61253", "l": "H2O + L-valine + O2 => 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41312", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432172", "l": "Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72658", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 <=> 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21557", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine => [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18470", "l": "an acyl-CoA + L-glutamine => an N(2)-acyl-L-glutamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36240", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140696", "l": "factor V -> factor Va + factor V activation peptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050505", "l": "hydroquinone glucosyltransferase activity", "d": ["Catalysis of the reaction: hydroquinone + UDP-D-glucose = H+ + hydroquinone O-beta-D-glucopyranoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58822", "l": "acetate + CO2 + Na(+)(out) => H(+) + malonate + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373705", "l": "Caspase cleavage of DCC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71232", "l": "2 Fe(3+)-[Dph3] + NADH => 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10824", "l": "(S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564169", "l": "Collagen type VIII degradation by MMP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.60", "l": "\"2-hydroxy-3-oxopropionate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760402", "l": "ILF3 binds HOXC8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14505", "l": "2 glutathione + thiosulfate = glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": [], "t": []}, {"i": "EC:2.8.1.3", "l": "\"thiosulfate--thiol sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50077", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50272", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658435", "l": "RAS GAPs bind RAS:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840488", "l": "PSAP(195-273) forms a dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47482", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => deoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4647593", "l": "EP400 binds CDKN1A promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23774", "l": "2,3-dihydroxy-p-cumate + H(+) + NADH => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14729", "l": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.13", "l": "\"fructose-bisphosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74371", "l": "a carboxylate(out) + nicotinate(in) = a carboxylate(in) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48111", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71597", "l": "2-oxoglutarate(in) + succinate(out) => 2-oxoglutarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174445", "l": "RPA binds to the Flap on the C-strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043777", "l": "cobalt-precorrin-7 C15-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193702", "l": "Part of the ICD migrates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047360", "l": "undecaprenyl-phosphate galactose phosphotransferase activity", "d": ["Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726949", "l": "PTGIR binds PTGIR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18823", "l": "acetylcholine + CoA => acetyl-CoA + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25833", "l": "1D-chiro-inositol + NAD(+) => H(+) + NADH + scyllo-inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327746", "l": "FN1 aggregation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51314", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629166", "l": "Defective NEIL1 variants do not cleave Tg (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13427", "l": "a pyrimidine nucleobase + D-ribose 5-phosphate => a pyrimidine ribonucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56993", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => (+)-costunolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009905", "l": "ent-copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863471", "l": "LDLR is bound by DAB2 and ARH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64075", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201611", "l": "Caspase-mediated cleavage of Rock-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3899291", "l": "SUMOylation of EP300 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10358", "l": "5beta-androstane-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5beta-androstan-17-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60077", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801109", "l": "CHM binds RGGT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54011", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710106", "l": "ELANE cleaves GSDMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42214", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51211", "l": "20-hydroxy-leukotriene B4 + NADP(+) <=> 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41453", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 => 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047697", "l": "beta-alanopine dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-beta-alanopine + H2O + NAD+ = beta-alanine + H+ + NADH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400143", "l": "Fatty acid ligands activate PPARA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56944", "l": "AH2 + D-ribulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48891", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23891", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine <=> [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031208", "l": "POZ domain binding", "d": ["Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-901047", "l": "Binding of ERp57 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15048", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21175", "l": "L-idonate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42675", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 <=> gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954056", "l": "E2F6 binds TFDP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53740", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O = [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681980", "l": "ATG12 binds ATG7 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41789", "l": "acetyl-CoA + holo-[ACP] => acetyl-[ACP] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981621", "l": "Neuroglobin:oxygen dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33283", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.66", "l": "\"2-hydroxycyclohexanone 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193703", "l": "IKKbeta is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43472", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20251", "l": "D-alanine => L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679044", "l": "FKBP1A binds sirolimus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56799", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] <=> adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173723", "l": "C8 binds C5b:C6:C7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15849", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate = 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822532", "l": "ADAMTS13 cleaves VWF multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052637", "l": "delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55205", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine => 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60683", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) <=> (+)-artemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015496", "l": "putrescine:ornithine antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18069", "l": "L-arginine = D-arginine", "d": [], "t": []}, {"i": "EC:5.1.1.9", "l": "\"arginine racemase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30417", "l": "formate + H2O + heptadecane + 2 NADP(+) => H(+) + 2 NADPH + O2 + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835411", "l": "FA core complex:HSP70s binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23008", "l": "alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:3.2.1.93", "l": "\"alpha,alpha-phosphotrehalase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26286", "l": "Co-precorrin-5B + S-adenosyl-L-methionine => Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602454", "l": "proMMP9 binds TIMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46809", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine => [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41552", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + ophiobolin F", "d": [], "t": []}, {"i": "EC:4.2.3.145", "l": "\"ophiobolin F synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24590", "l": "ADP + D-arabinose 5-phosphate + H(+) => ATP + D-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4837364", "l": "Secretion of SOD3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20996", "l": "(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.5", "l": "\"2-aminomuconate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696605", "l": "USP12, USP26 deubiquitinate AR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683925", "l": "ULK1 is dephosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37039", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332356", "l": "CAMK2 binds MAP3K7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0050355", "l": "inorganic triphosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71550", "l": "5-phosphomethyl-dUMP in DNA + glycine <=> 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72567", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) = dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30175", "l": "15-cis-phytoene + 2 plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672817", "l": "Active MTORC1 binds the ULK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34014", "l": "5-dehydroepisterol + 2 H2O + NADP(+) <=> ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45496", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22458", "l": "sarcosine + urea => creatine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43913", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003839", "l": "gamma-glutamylcyclotransferase activity", "d": ["Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211224", "l": "Association of DFF40 with DFF45 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32300", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH => 2 diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63575", "l": "H2O + neurotensin-(1-8) <=> L-arginine + neurotensin-(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77181", "l": "CO2 + H2O + uridine-5'-carboxamide => (5'S,6'R)-C-glycyluridine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008946", "l": "oligonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809707", "l": "MTMR12 binds MTMR2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14374", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41433", "l": "3-methyl-L-tyrosine + H2O2 => 5-hydroxy-3-methyl-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112727", "l": "Serine phosphorylation of STATs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35767", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine = 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70318", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38572", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) => a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45418", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+) => 11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390846", "l": "D2D3,4 bind to DA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698933", "l": "HCMV B Nucleocapsid Translocation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17416", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19317", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64509", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39039", "l": "an omega-oxo fatty acid + H2O + NAD(+) = a dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70400", "l": "3-oxosphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44370", "l": "Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide => Cr(6+) + 2 NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362522", "l": "ALDHs oxidise atRAL to atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938121", "l": "SERPINB13 binds CTSK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60557", "l": "uridine(35) in tRNA(Tyr) => pseudouridine(35) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862700", "l": "CMKLR1 binds Resolvin E1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54510", "l": "beta-heptaprene + diphosphate => all-trans-heptaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102869", "l": "6-hydroxyflavone-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone = 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168888", "l": "Alpha1-Microglobulin binds heme (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990943", "l": "mating type region replication fork barrier binding", "d": ["Binding to the replication fork barrier found in the mating type region of fission yeast."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001626", "l": "nociceptin receptor activity", "d": ["Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33995", "l": "gamma-L-glutamyl-butirosin B = 5-oxo-L-proline + butirosin B", "d": [], "t": []}, {"i": "EC:4.3.2.6", "l": "\"gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031802", "l": "type 5 metabotropic glutamate receptor binding", "d": ["Binding to a type 5 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9834807", "l": "ILF3 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693478", "l": "HTR1A binds HTR1A agonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38183", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141437", "l": "Formation of the MCC complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696670", "l": "CHD1L is recruited to GG-NER site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213241", "l": "Formation of nonameric complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426151", "l": "SREBP1A,2 binds the SQLE promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49380", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44250", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9702849", "l": "CALCR binds gepants (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684261", "l": "MAP3K8 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48130", "l": "(2E,6E)-farnesyl phosphate + H(+) + phosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.25", "l": "\"vibriolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55177", "l": "2-oxoglutarate + butanoyl-CoA + O2 => 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16983", "l": "H(+) + maleylacetate + NADH => 3-oxoadipate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001601", "l": "peptide YY receptor activity", "d": ["Combining with gut peptide YY to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10032", "l": "[protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.43", "l": "\"peptidyl-glutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051477", "l": "mannosylglycerate transmembrane transporter activity", "d": ["Enables the transfer of a mannosylglycerate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209224", "l": "SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26440", "l": "3-oxopropanoate + H(+) + NADPH => 3-hydroxypropanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12472", "l": "H2O + N-ethylglycine + O2 = ethylamine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27362", "l": "chloride + S-adenosyl-L-methionine => chloromethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29631", "l": "D-maltotetraose + H2O = alpha-D-glucose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13082", "l": "biotin amide + H2O => biotin + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034581", "l": "4-methyloct-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36265", "l": "acetate + H(+) + O-ureido-L-serine => hydroxyurea + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432164", "l": "Ca2+ influx into the post-synaptic cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52971", "l": "hyocholate + UDP-alpha-D-glucuronate <=> H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24660", "l": "H(+) + L-arginine + NADPH + O2 = H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033424", "l": "CCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52989", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691154", "l": "HFE binds TFRC dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799332", "l": "ATR phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0051428", "l": "peptide hormone receptor binding", "d": ["Binding to a receptor for a peptide hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114544", "l": "p115-RhoGEF activation of RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855047", "l": "Hydrolysis of internal thioester in C4b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047260", "l": "alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity", "d": ["Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045481", "l": "6-endo-hydroxycineole dehydrogenase activity", "d": ["Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + H+ + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873918", "l": "Transphosphorylation of JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41014", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603791", "l": "PEX16:PEX19:PEX3 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31116", "l": "ATP + biotin + H(+) => biotinyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76279", "l": "hypoxanthine(out) + Na(+)(out) = hypoxanthine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637808", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44414", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-10 => 3-demethylubiquinol-10 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30342", "l": "H(+) + L-tryptophan <=> CO2 + tryptamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53351", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57976", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside C-K + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48829", "l": "H(+) + NADPH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74352", "l": "2 (S)-lactate(in) + prostaglandin E3(out) => 2 (S)-lactate(out) + prostaglandin E3(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75350", "l": "thiocyanate(in) <=> thiocyanate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49105", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64878", "l": "H(+) + phosphate + UMP => H2O + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39463", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA = (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76826", "l": "H2O + methylamine + NAD(+) <=> formaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67938", "l": "a 2-oxocarboxylate + H2O2 => a 2-hydroxy carboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32470", "l": "2 S-adenosyl-L-methionine + sarcosine <=> glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44479", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879770", "l": "Expression of DEC2 (BHLHE41, BHLHB3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050086", "l": "mannitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64522", "l": "A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde => acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73495", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine = an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53635", "l": "(2E,6E)-farnesyl diphosphate <=> (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72642", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0099510", "l": "calcium ion binding involved in regulation of cytosolic calcium ion concentration", "d": ["The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49614", "l": "2-oxoglutarate + H(+) + NADH => (R)-2-hydroxyglutarate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21419", "l": "NADP(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13749", "l": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.10", "l": "\"nucleoside-triphosphate--adenylate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41859", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419843", "l": "CALCA(83-119) binds CALCR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67022", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49549", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => H(+) + L-arginyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.-.-.-", "l": "\"Isomerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944233", "l": "Association of procollagen type XIX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111962", "l": "PDE4A,C,D hydrolyse cAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110219", "l": "Cleavage of thymine by TDG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55643", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68756", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31399", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) = all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50872", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 = (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44356", "l": "nogalaviketone = methyl nogalonate", "d": [], "t": []}, {"i": "EC:5.5.1.26", "l": "\"nogalonic acid methyl ester cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190065", "l": "Activated TrkA receptor internalizes to endosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854209", "l": "TBC1D10A binds JFC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74258", "l": "H2O + L-homoseryl-tRNA(Ser) <=> H(+) + L-homoserine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20494", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42263", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] <=> 3-oxononanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167115", "l": "Addition of nucleotides between position +11 and +30 on HIV-1 transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655142", "l": "RCHY1 binds POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879674", "l": "CD97 binds CD55 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835328", "l": "NPM binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762343", "l": "PREDL:ALB dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60290", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102885", "l": "alpha-cuprenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12138", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74051", "l": "D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36354", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24461", "l": "H(+) + malonyl-[ACP] => acetyl-[ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74725", "l": "3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23675", "l": "a quinone + L-quinate <=> 3-dehydroquinate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019168", "l": "2-octaprenylphenol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48676", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32945", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46884", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25173", "l": "H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26506", "l": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35084", "l": "diacetylchitobiose-6'-phosphate + H2O => acetate + N'-monoacetylchitobiose-6'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26450", "l": "CoA + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.1.76", "l": "\"succinate-semialdehyde dehydrogenase (acetylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74467", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O = a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50046", "l": "adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+) => an acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40439", "l": "6-sulfo-beta-D-quinovose = 6-deoxy-6-sulfo-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0010277", "l": "chlorophyllide a oxygenase [overall] activity", "d": ["Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27892", "l": "phosphate + uridine => 3'-UMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787567", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32403", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987223", "l": "IL10RB binds TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173705", "l": "C5b binds C6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433808", "l": "viral dsRNA: TLR3: TICAM1 recruits TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030226", "l": "apolipoprotein receptor activity", "d": ["Combining with an apolipoprotein to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114256", "l": "CYCS:APAF1 binds procaspase-9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56152", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980044", "l": "NOTCH1 binds JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15356", "l": "all-trans-violaxanthin + L-ascorbate <=> all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795473", "l": "PDPK1 phosphorylates SGK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64744", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine = 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48859", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982637", "l": "Opsins binds G alpha-t (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43862", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797553", "l": "Protein 4.1 binds CASK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0000386", "l": "second spliceosomal transesterification activity", "d": ["Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure."], "t": []}, {"i": "REACT:R-HSA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112123", "l": "Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392834", "l": "Activation of EPACs by cAMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76021", "l": "18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin] => cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65574", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62135", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817692", "l": "BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374669", "l": "L1 binds NRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64150", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GalNAc-R + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12801", "l": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019534", "l": "toxin transmembrane transporter activity", "d": ["Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052881", "l": "4-hydroxyphenylacetate 3-monooxygenase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O2 = 3,4-dihydroxyphenylacetate + FAD + H+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798345", "l": "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11816", "l": "alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.9", "l": "\"glucose-6-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674529", "l": "AAMP binds to TBXA2R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690494", "l": "RHOB translocates to the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41054", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37147", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68186", "l": "a medium chain fatty acid + CoA + H(+) => a medium-chain fatty acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39005", "l": "a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66313", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O => a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008257", "l": "protein histidine tele-kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35194", "l": "noranthrone + O2 <=> H2O + norsolorinic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67581", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate => adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718379", "l": "GNRHR binds chemical antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70651", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65249", "l": "AH2 + 5 H(+) + 5 malonyl-CoA => 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848023", "l": "Activated PTK6 binds STAP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624112", "l": "CEBPA binds CDK4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44450", "l": "a 3-oxoacyl-[ACP] + CO2 + CoA => an acyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13004", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031616", "l": "EGR binds ARC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71301", "l": "chloride(in) + L-isoleucine(in) + 2 Na(+)(in) => chloride(out) + L-isoleucine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74943", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 = a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002440", "l": "Removal of fibrillar collagen C-propeptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50083", "l": "ATP + H2O + taurodeoxycholate(in) <=> ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72400", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) => 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015551", "l": "3-hydroxyphenyl propanoate transmembrane transporter activity", "d": ["Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76793", "l": "9-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102539", "l": "UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691150", "l": "TFR2 dimer binds 2xholoTF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12635", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => benzoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20484", "l": "3'-phosphoadenylyl sulfate + coelenterazine h <=> adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428262", "l": "ACER3 hydrolyzes phytoceramide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54345", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13793", "l": "2-methyleneglutarate = 2-methylene-3-methylsuccinate", "d": [], "t": []}, {"i": "EC:5.4.99.4", "l": "\"2-methyleneglutarate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167419", "l": "The receptor:G-protein complex releases GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051700", "l": "fructosyl-amino acid oxidase activity", "d": ["Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336182", "l": "GPR37 binds prosaptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24053", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10009", "l": "[protein]-dithiol + a hydroperoxide => [protein]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451310", "l": "Activation of Edited Kainate receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38520", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10914", "l": "(R)-pantothenate + AMP + diphosphate + H(+) => (R)-pantoate + ATP + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433415", "l": "Activation of RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58794", "l": "ADP + Fe(III)-petrobactin(in) + H(+) + phosphate => ATP + Fe(III)-petrobactin(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70692", "l": "ornithine => putrescine + CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48986", "l": "2,4-dichlorophenol + CO2 + glyoxylate + succinate => (2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24268", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.40", "l": "\"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56538", "l": "1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33449", "l": "3-dehydro-4-methylzymosterol + CO2 + NADPH => 4beta-methylzymosterol-4alpha-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030768", "l": "16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53758", "l": "allodeoxycholate + choloyl-CoA => allodeoxycholoyl-CoA + cholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473594", "l": "Collagen type II degradation by MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42157", "l": "androsterone + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140851", "l": "histone H3K14 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-14 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14024", "l": "AH2 + ecdysone + O2 <=> 20-hydroxyecdysone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052650", "l": "NADP-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10592", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803892", "l": "SFN dimer binds BAX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173725", "l": "C9 binds C5b:C6:C7:C8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33509", "l": "(2E)-hexadecenal + phosphoethanolamine => sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047645", "l": "alkan-1-ol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50465", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH => 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52819", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682011", "l": "LC3 binds ATG7 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42394", "l": "D-galactono-1,5-lactone + H(+) + NADH => D-galactose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388814", "l": "Grb2 binds CD28 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65454", "l": "CoA + ethyl hexanoate => ethanol + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73787", "l": "dimethylallyl diphosphate + tardioxopiperazine A = diphosphate + variecolorin L", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42280", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950608", "l": "Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790029", "l": "Expression of PTGS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76508", "l": "(-)-2'-epi-GR24 + H2O => (-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16658", "l": "H2O + inosine => D-ribose + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34842", "l": "4 H(+) + 5 malonyl-CoA <=> 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352946", "l": "fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + glyceraldehyde 3-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60939", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033786", "l": "heptose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30282", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21517", "l": "isopiperitenone => piperitenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76145", "l": "ervincine + H(+) + S-adenosyl-L-homocysteine => picrinine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19932", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20965", "l": "2-oxoglutarate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44262", "l": "4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.13", "l": "\"(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24920", "l": "L-homoserine => 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33396", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester => GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67756", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29789", "l": "ADP + glutathione(out) + H(+) + phosphate => ATP + glutathione(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031797", "l": "type 2 metabotropic GABA receptor binding", "d": ["Binding to a type 2 metabotropic GABA receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57512", "l": "chlorobenzene + H(+) + NADH + O2 = (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.26", "l": "\"chlorobenzene dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688834", "l": "ATXN3 binds VCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49994", "l": "H2O + NAD(+) + propan-2-ol => H(+) + NADH + O2 + propane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672951", "l": "Inactive RAFs bind YWHAB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140482", "l": "iron sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032542", "l": "sulfiredoxin activity", "d": ["Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018518", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity", "d": ["Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17921", "l": "D-arabinitol + NAD(+) = D-xylulose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.11", "l": "\"D-arabinitol 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0008373", "l": "sialyltransferase activity", "d": ["Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374664", "l": "Phosphorylation and activation of Ezrin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227964", "l": "ERBB2 homodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22693", "l": "3-hydroxybenzoate + H(+) + NADH + O2 => 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046563", "l": "methanol oxidase activity", "d": ["Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53856", "l": "NADP(+) + ursocholate = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70796", "l": "H(+)(in) + L-lysine(out) => H(+)(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45028", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.12", "l": "\"(2S)-methylsuccinyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48798", "l": "19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50982", "l": "prostaglandin E1(in) => prostaglandin E1(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994148", "l": "LRRC16A binds F-actin capping protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433456", "l": "Recruitment of STATs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50440", "l": "prostaglandin H1 = prostaglandin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75032", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate => (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34395", "l": "L-phenylalanine = L-beta-phenylalanine", "d": [], "t": []}, {"i": "EC:5.4.3.10", "l": "\"phenylalanine aminomutase (L-beta-phenylalanine forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042123", "l": "glucanosyltransferase activity", "d": ["Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53433", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607746", "l": "PKC-delta is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70899", "l": "histidine => urocanate + NH4+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823816", "l": "OPTN binds CASP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61924", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O = (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070738", "l": "tubulin-glycine ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58403", "l": "heptan-1-ol + NADP(+) <=> H(+) + heptanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13217", "l": "H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832205", "l": "Expression of LFNG during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646354", "l": "PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38454", "l": "hydrogen sulfide + NADP(+) + n sulfur <=> NADPH + (n+1) sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76007", "l": "(3R)-hydroxybutanoate pentamer + H2O = (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55262", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76851", "l": "(S)-sec-butylamine + H2O + NAD(+) = butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39989", "l": "all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42869", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine => caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21087", "l": "chondroitin 4'-sulfate <=> dermatan 4'-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.62", "l": "\"multiple inositol-polyphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38661", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22724", "l": "a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.173", "l": "\"sterol 3beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52805", "l": "(2E,6E)-farnesyl diphosphate => (+)-eremophilene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.43", "l": "\"lipid A phosphoethanolamine transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209357", "l": "N-HH is palmitoylated by RASP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212642", "l": "L-Glutamine transport into neurons (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49505", "l": "phosphinomethylmalate => phosphinomethylisomalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875568", "l": "RAPGEF1 activates RAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48741", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19243", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36555", "l": "eicosanoyl-CoA + sphinganine = CoA + H(+) + N-eicosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033719", "l": "2-oxo-acid reductase activity", "d": ["Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60800", "l": "2-oxoglutarate + gibberellin A53 + O2 = CO2 + gibberellin A44 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33989", "l": "diphosphate + neoabietadiene => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389026", "l": "Galanin receptors can bind galanin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69053", "l": "RFC binding displaces Pol Alpha (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71830", "l": "arsenate(in) + H(+)(in) <=> arsenate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76509", "l": "(-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one => (-)-2'-epi-GR24 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35917", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11081", "l": "dTMP + H2O => phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390930", "l": "5-HT2 receptor can bind serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49383", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71169", "l": "glycine(in) + H(+)(out) + Na(+)(in) => glycine(out) + H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689861", "l": "Recruitment of XPA and release of CAK  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24884", "l": "H(+) + L-glutamate + NADPH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19033", "l": "an N-acyl-D-glucosamine = an N-acyl-D-mannosamine", "d": [], "t": []}, {"i": "EC:5.1.3.8", "l": "\"N-acylglucosamine 2-epimerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18032", "l": "2 ATP + hydrogencarbonate + NH4(+) <=> 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37356", "l": "H2O + uridine 2'-phosphate => phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53566", "l": "18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33482", "l": "an acyl-CoA + lanosterol <=> CoA + lanosteryl ester", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604664", "l": "ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39798", "l": "7beta-hydroxycholesterol(in) + ATP + H2O <=> 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961699", "l": "FBXO5 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72361", "l": "glutarate(out) + succinate(in) => glutarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828025", "l": "DCN (decorin) degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10273", "l": "a 1,2-diacyl-sn-glycerol + ATP => a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64568", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72840", "l": "ADP(out) + CoA(in) => ADP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40062", "l": "decanoyl-CoA + H2O <=> CoA + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21231", "l": "alpha-maltose <=> beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63626", "l": "AMP + H(+) + hexadecanoyl-[ACP] => hexadecanoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72756", "l": "3 ATP => 3',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22882", "l": "L-glutamate + prephenate => 2-oxoglutarate + L-arogenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45348", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507873", "l": "Aquaporins passively transport urea out of cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32623", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15712", "l": "kaempferol + UDP-alpha-D-galactose <=> H(+) + kaempferol 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13215", "l": "2 H(+) + NADPH + succinate => H2O + NADP(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14041", "l": "(R)-vicianin + H2O = mandelonitrile + vicianose", "d": [], "t": []}, {"i": "EC:3.2.1.119", "l": "\"vicianin beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43639", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54633", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA => 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61945", "l": "24-methylenecholesterol + UDP-alpha-D-glucose => 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44103", "l": "H2O + NAD(+) + octanal <=> 2 H(+) + NADH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760122", "l": "AcK-NFE2L2-dependent GCLC gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56374", "l": "3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+) => 3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32719", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43910", "l": "D-galactose + sphing-4-enine => beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225957", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865994", "l": "GAB1 binds PTPN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62126", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + GDP => a 2'-deoxyribonucleoside 5'-phosphate + GTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1671687", "l": "PRLR activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114354", "l": "SMAC binds XIAP:Caspase-7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57727", "l": "H(+) + 2 Na(+)(in) + oxaloacetate <=> CO2 + 2 Na(+)(out) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33167", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086085", "l": "cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64347", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 <=> 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16583", "l": "2 Fe(III)-[cytochrome c] + 2 H2O => 2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018643", "l": "carbon disulfide oxygenase activity", "d": ["Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47395", "l": "H2O + hexadecanoate ester <=> an aliphatic alcohol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730847", "l": "Hydrolysis of PIP2 by PLCG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51866", "l": "8-geranylesculetin + diphosphate => (2E)-geranyl diphosphate + esculetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650165", "l": "ASIC trimers bind H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60516", "l": "L-tryptophan = D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40105", "l": "CoA + H(+) + propanoate => H2O + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19527", "l": "(1S,8aR)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106274", "l": "NAD+-protein-arginine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34759", "l": "ATP + glycerol 2-phosphate(out) + H2O = ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36576", "l": "(9Z)-octadecenoyl-CoA + sphinganine => CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33288", "l": "A + spermidine => 1-pyrroline + AH2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797293", "l": "Expression of IL18, ALOX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296127", "l": "Activation of voltage gated Potassium channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12198", "l": "acetyl phosphate + D-erythrose 4-phosphate + H2O => keto-D-fructose 6-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39768", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75401", "l": "2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in) => 2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17557", "l": "anthranilate + malonyl-CoA = CoA + N-malonylanthranilate", "d": [], "t": []}, {"i": "EC:2.3.1.113", "l": "\"anthranilate N-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086410", "l": "CDK1 phosphorylates BORA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695949", "l": "SPHK2 phosphorylates sphingoid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36647", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48762", "l": "H(+) + L-erythrulose + NADH => L-threitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0032555", "l": "purine ribonucleotide binding", "d": ["Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69074", "l": "Formation of Processive Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167191", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984226", "l": "PLK1 phosphorylates NEK9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61470", "l": "a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102372", "l": "alpha-amyrin 28-monooxygenase activity", "d": ["Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ = uvaol + NADP(3-) + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0034353", "l": "mRNA 5'-diphosphatase activity", "d": ["Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061775", "l": "cohesin loader activity", "d": ["Facilitating a conformational change to load a cohesin complex around sister chromatids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322431", "l": "XIAP binds TLE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37854", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41436", "l": "(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2 => (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20117", "l": "ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.5", "l": "\"rhamnulokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62654", "l": "6 CO2 + 7 CoA + H2O + naphtopyrone YWA1 => acetyl-CoA + 6 H(+) + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29281", "l": "H2O + menaquinone-8 + trimethylamine => H(+) + menaquinol-8 + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805620", "l": "KAT6A and PML bind TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445448", "l": "HHIP binds Hedgehog (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21384", "l": "L-phenylalanine = (E)-cinnamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34552", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine => ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33611", "l": "H2O + methyl salicylate = H(+) + methanol + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65811", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63322", "l": "a glycerophospholipid(out) + ADP + H(+) + phosphate => a glycerophospholipid(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42126", "l": "androsterone + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72563", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) = butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429860", "l": "DCP1-DCP2 complex decaps mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18656", "l": "barbiturate + H2O <=> 3-oxo-3-ureidopropanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211904", "l": "CYP4F12 18-hydroxylates ARA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67294", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.102", "l": "\"DNA primase AEP\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68981", "l": "NADP(+) + tauroursodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40778", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O <=> D-alpha-phenylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28558", "l": "D-fructose 6-phosphate + H2O = D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77225", "l": "5'-deoxyadenosine + cob(III)alamin + geneticin + L-methionine => gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49382", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41790", "l": "acetyl-[ACP] + CoA => acetyl-CoA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11396", "l": "5-methyldeoxycytidine 5'-phosphate + ATP = 5-methyldeoxycytidine diphosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.19", "l": "\"5-methyldeoxycytidine-5'-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20835", "l": "ATP + guanine(out) + H2O <=> ADP + guanine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166544", "l": "TrkA receptor autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72510", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) <=> 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693598", "l": "ATM phosphorylates NBN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51761", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35094", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20389", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013024", "l": "RHOB binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32015", "l": "(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.97", "l": "\"(-)-delta-cadinene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65301", "l": "2-oxoglutarate + chrodrimanin C + O2 => CO2 + H2O + succinate + verruculide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72301", "l": "3,3',5-triiodo-L-thyronine(in) + L-glutamate(out) => 3,3',5-triiodo-L-thyronine(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317387", "l": "PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18226", "l": "[N-(6-aminohexanoyl)](n) + H2O => 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10677", "l": "(2R,3S)-3-isopropylmalate => 2-isopropylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61213", "l": "myricetin + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61287", "l": "H2O + L-cystine + O2 <=> (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34527", "l": "L-phenylalanine = (S)-3-amino-3-phenylpropanoate", "d": [], "t": []}, {"i": "EC:5.4.3.11", "l": "\"phenylalanine aminomutase (D-beta-phenylalanine forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141437", "l": "Formation of the MCC complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047168", "l": "isocitrate O-dihydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74986", "l": "Elongation of pre-rRNA transcript (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047937", "l": "glucose-1-phosphate phosphodismutase activity", "d": ["Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9833777", "l": "PKR binds activating host RNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.320", "l": "\"benzil reductase [(S)-benzoin forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25881", "l": "2 L-dopa + O2 => 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72983", "l": "dimethylallyl diphosphate + harmol = 6-(3-dimethylallyl)harmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733495", "l": "Viral Spike Binds to ACE2 on Uninfected Cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696482", "l": "CTF1 binds LIFR:JAKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20888", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.4", "l": "\"3-hydroxyisobutyryl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694467", "l": "Spike protein forms a homotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58411", "l": "NADP(+) + undecan-1-ol <=> H(+) + NADPH + undecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57556", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72697", "l": "Start codon recognition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047192", "l": "1-alkylglycerophosphocholine O-acetyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33495", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.n9", "l": "\"heptaprenylglyceryl phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047647", "l": "alkylacetylglycerophosphatase activity", "d": ["Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = 2-acetyl-1-alkyl-sn-glycerol + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9714580", "l": "SLC6A3 binds DRIs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59863", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38766", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432036", "l": "Aquaporin-6 passively transports anions out of vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46882", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855111", "l": "VLDLR binds PCSK9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944240", "l": "Association of procollagen type III (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48767", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) <=> 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36273", "l": "formaldehyde + H2O + NADP(+) + theobromine => caffeine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047757", "l": "chondroitin-glucuronate 5-epimerase activity", "d": ["Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198314", "l": "DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.27", "l": "\"DNA beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090562", "l": "protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64164", "l": "2-methyl-L-serine = formaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382053", "l": "Translocation of PDGF from ER to Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64971", "l": "dUTP + H2O <=> dUDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791054", "l": "Expression of GSK3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984733", "l": "Kinesin-3 is a dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46535", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847537", "l": "RAB43:GTP binds USP8NL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16843", "l": "H(+) + precorrin-3A + S-adenosyl-L-homocysteine => precorrin-2 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73815", "l": "O2 + piceatannol = 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57818", "l": "2-deoxy-D-ribose 5-phosphate + guanine => dGMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30267", "l": "2 monodehydro-L-ascorbate radical = L-ascorbate + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983259", "l": "Kinesins move along microtubules consuming ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25652", "l": "(2R,5R)-isopulegone + NADP(+) <=> (6R)-isopiperitenone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68680", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) = 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211482", "l": "HNF1A-dependent synthesis of FOXA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19941", "l": "norcoclaurine + S-adenosyl-L-methionine = coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418553", "l": "cAMP degradation by Phosphodiesterases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47614", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871226", "l": "RET binds GFRA1,GFRA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54300", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42345", "l": "H(+) + NADH + O2 + p-cumate => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102968", "l": "10-hydroxygeranial oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP = (6E)-8-oxogeranial + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050797", "l": "thymidylate synthase (FAD) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77010", "l": "(2S)-5,5-dimethylpiperidine-2-carboxylate + 10-hydroxy-pre-flavunoidine + ATP <=> AMP + diphosphate + flavunoidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809010", "l": "COPI vesicle uncoating (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803914", "l": "TP53 binds the RGCC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168947", "l": "Ligand binds to TLR10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0016671", "l": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide."], "t": []}, {"i": "EC:1.8.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879674", "l": "CD97 binds CD55 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019797", "l": "procollagen-proline 3-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61704", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine = AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.72", "l": "\"L-serine--[L-seryl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804229", "l": "JMY, TTC5 and EP300 bind (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28605", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635861", "l": "NUMB:ITCH binds GLI1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18851", "l": "a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791319", "l": "NID1 degradation by MMP19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49838", "l": "(5E)-tetradecenoyl-(R)-carnitine + CoA => (5E)-tetradecenoyl-CoA + (R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28274", "l": "(S)-S-adenosyl-L-methionine = (R)-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51827", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49853", "l": "(3E)-octenoyl-CoA => (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936729", "l": "sulfate is activated to APS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56326", "l": "2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein] => (2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75590", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose <=> erinacine Q2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726949", "l": "PTGIR binds PTGIR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.21", "l": "\"Cd(2+)-exporting ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9621179", "l": "Cinaciguat binds sGC:NO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034533", "l": "1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15698", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102754", "l": "chlorophyllide-b:phytyl-diphosphate phytyltransferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate = chlorophyll b + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341072", "l": "SUMOylation of RARA with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050149", "l": "o-aminophenol oxidase activity", "d": ["Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805126", "l": "AURKB phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938053", "l": "RUNX1:CBFB binds the SERPINB13 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20246", "l": "ATP + streptomycin => 3''-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18963", "l": "H2O + N(6)-(D-psicosyl)-L-lysyl-[protein] => D-allose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30189", "l": "a quinol + orotate => (S)-dihydroorotate + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604763", "l": "Autocatalytic activation of MMP7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62131", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10787", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73632", "l": "CTP(out) + dGTP(in) => CTP(in) + dGTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74457", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007591", "l": "E2F6 binds RRM2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981621", "l": "Neuroglobin:oxygen dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111883", "l": "Hydrolysis of phosphatidylcholine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56666", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57253", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP => glycolate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102384", "l": "19-O-beta-glucopyranosyl-steviol glucosyltransferase activity", "d": ["Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose = rubusoside + UDP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45149", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20315", "l": "1D-myo-inositol hexakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21440", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062204", "l": "(13S)-vitexifolin A synthase activity", "d": ["Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate."], "t": []}, {"i": "RHEA:40027", "l": "9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20293", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30940", "l": "ATP + dIDP => ADP + dITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607721", "l": "Activation of NIK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22291", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43077", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38700", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15584", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA <=> biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20384", "l": "androsterone + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38949", "l": "12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56415", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45265", "l": "(9Z,12Z)-octadecadienoate(out) => (9Z,12Z)-octadecadienoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28286", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39967", "l": "2-aminobut-2-enoate = 2-iminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51311", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 <=> H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030620", "l": "U2 snRNA binding", "d": ["Binding to a U2 small nuclear RNA (U2 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11028", "l": "ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112514", "l": "JAK activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981926", "l": "RAC1 and CDC42 activate PAK3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14103", "l": "[eIF5A protein]-hypusine + A + H2O => [eIF5A protein]-deoxyhypusine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68644", "l": "(2E)-geranyl diphosphate = alpha-thujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53742", "l": "[Rab1 protein]-L-tyrosine + AMP + H(+) => [Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944250", "l": "Association of procollagen type XXV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44487", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75896", "l": "holothin + marinoloyl-CoA C => CoA + thiomarinol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56334", "l": "AMP + ATP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62649", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77519", "l": "furfural + hydrogen cyanide = (2R)-2-(furan-2-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006143", "l": "CD46 binds C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0016247", "l": "channel regulator activity", "d": ["Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.513561067274054", "identifiers": [{"i": "GO:0016702", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26429", "l": "ATP + H2O + L-glutamine + UTP <=> ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25746", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9623384", "l": "α1-agonists bind ADRA1A,B,D (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11177", "l": "kojibiose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684836", "l": "CLEC1B dimer binds PDPN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102170", "l": "5-epi-aristolochene-1,3-dihydroxylase activity", "d": ["Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 = capsidiol + 2 NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68073", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH => L-thiazolidine-2-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31466", "l": "crocetin + UDP-alpha-D-glucose <=> beta-D-glucosyl crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67668", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9736953", "l": "FURIN translocates to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47925", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40945", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26376", "l": "[thioredoxin]-disulfide + prostamide F2alpha <=> [thioredoxin]-dithiol + prostamide H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112604", "l": "Phosphorylated STATs are released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40375", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63893", "l": "ATP + H2O + L-tryptophan => AMP + D-tryptophan + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46359", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59717", "l": "D-maltopentaono-1,5-lactone + H2O => D-maltopentaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400204", "l": "PPARA binds RXRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804527", "l": "INTL1 binds bacterial glycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61773", "l": "rebaudioside E + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50813", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749098", "l": "ORC1 binds to DNA at origin of replication sites (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28911", "l": "H(+)(out) + L-lysine(out) = H(+)(in) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20772", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": [], "t": []}, {"i": "EC:2.5.1.9", "l": "\"riboflavin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168136", "l": "Activated JNKs phosphorylate c-JUN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22432", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.35", "l": "\"3-hydroxyacyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-996755", "l": "ZFPM proteins bind GATA proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483174", "l": "PE is methylated to PC by PEMT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44883", "l": "ATP + L-threonyl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55134", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate => ATP + D-alanine + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619376", "l": "CAMK1 binds calmodulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41684", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452353", "l": "Expression of EOMES in the primitive streak (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25546", "l": "diphosphate + ent-pimara-9(11),15-diene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.10", "l": "\"ferric-chelate reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43861", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56423", "l": "apo-[D-alanyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49538", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O => 2-amino-2-deoxy-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:2001062", "l": "xylan binding", "d": ["Binding to xylan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928646", "l": "EPHAs bind EFNAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73402", "l": "D-aspartate(in) + sulfate(out) <=> D-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866941", "l": "MID1IP1 binds THRSP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13156", "l": "(R)-glycerate + CO2 + NAD(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004087", "l": "carbamoyl-phosphate synthase (ammonia) activity", "d": ["Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56718", "l": "H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36451", "l": "ATP + glycyl-L-glutamate(out) + H2O = ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018758", "l": "RHOH binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33640", "l": "ATP + CoA + tetracosanoate => AMP + diphosphate + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58971", "l": "1-naphthaldehyde + H2O + O2 <=> 1-naphthoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25969", "l": "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37458", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69511", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone <=> H(+) + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69663", "l": "H2O + luteolin 7-O-beta-D-glucoside = beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56011", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724745", "l": "PLG(20-810) binds aprotinin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47544", "l": "trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19780", "l": "A + L-pipecolate <=> AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26156", "l": "D-mannose + NADP(+) = D-glucosone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35176", "l": "novobiocin(in) => novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38844", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70144", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54032", "l": "(6R)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27965", "l": "myo-inositol + pyrroloquinoline quinone <=> H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004422", "l": "hypoxanthine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22141", "l": "a nucleoside 5'-phosphate + H2O => a nucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700149", "l": "Active ALK binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42747", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75390", "l": "H2O + queuosine 5'-phosphate <=> D-ribose 5-phosphate + queuine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362793", "l": "Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268025", "l": "SAM50 complex inserts proteins into mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050237", "l": "pyridoxine 4-oxidase activity", "d": ["Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56328", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O = 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709842", "l": "MAVS binds TOMM70 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004890", "l": "GABA-A receptor activity", "d": ["Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25583", "l": "alpha-L-fucose <=> beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.42", "l": "\"thermopsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50988", "l": "prostaglandin F2alpha(out) = prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75509", "l": "n H(+)(in) + taurocholate(in) => n H(+)(out) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.57", "l": "\"phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18977", "l": "a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-178208", "l": "SMAD7 binds to SMURF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74258", "l": "XDH oxidizes xanthine to form urate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809764", "l": "SBF1 binds MTMR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15950", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48570", "l": "(2E,4Z)-2-chloromuconate + 2 H(+) => 3-chlorocatechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009558", "l": "IL34 dimer binds SDC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.347862406647948", "identifiers": [{"i": "GO:0043565", "l": "sequence-specific DNA binding", "d": ["Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42386", "l": "4,4'-diaponeurosporenoate + 2 H(+) + NADH => 4,4'-diaponeurosporenal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033914", "l": "xylan 1,3-beta-xylosidase activity", "d": ["Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36990", "l": "CMP + phosphate <=> alpha-D-ribose 1,5-bisphosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11284", "l": "hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate", "d": [], "t": []}, {"i": "EC:1.1.1.167", "l": "\"hydroxymalonate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15256", "l": "cis-aconitate + H(+) <=> CO2 + itaconate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16941", "l": "N-acetylindoxyl + O2 = H2O + N-acetylisatin", "d": [], "t": []}, {"i": "EC:1.7.3.2", "l": "\"acetylindoxyl oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65026", "l": "dehydrocholate + H(+) + NADPH => 7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052589", "l": "malate dehydrogenase (menaquinone) activity", "d": ["Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592436", "l": "Initial activation of proMMP9 by MMPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10062", "l": "CoA + H(+) + N-acetyl-D-tryptophan => acetyl-CoA + D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0099106", "l": "ion channel regulator activity", "d": ["Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13104", "l": "4-imidazolone-5-propanoate <=> H2O + trans-urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25239", "l": "ADP + CTP => ATP + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848812", "l": "HIF1A,EPAS1 bind PTK6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63802", "l": "GDP-beta-L-gulose => GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374916", "l": "Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20598", "l": "2 L-cysteine + NAD(+) => H(+) + L-cystine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837511", "l": "Abortive replication of hRSV A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76361", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59712", "l": "D-maltotetraono-1,5-lactone + H2O = D-maltotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68487", "l": "(2R)-2-hydroperoxydodecanoate + H(+) <=> CO2 + H2O + undecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035983", "l": "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956676", "l": "YAP1 binds TP73 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102788", "l": "4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75072", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) => chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13032", "l": "H2O + N-acetyl-D-glucosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46465", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45422", "l": "a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3828025", "l": "DCN (decorin) degradation by MMP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700171", "l": "Active ALK phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36758", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706304", "l": "Active FLT3 binds to GRAP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28975", "l": "H(+)(out) + L-asparagine(in) = H(+)(in) + L-asparagine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190682", "l": "Connexin synthesis (generic) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63202", "l": "(10bS,4aR)-oxomaritidine + NADP(+) => (10bS,4aR)-noroxomaritidine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77414", "l": "acrolein + hydrogen cyanide <=> (2S)-2-hydroxybut-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49974", "l": "16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635839", "l": "ULK3:SUFU dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201639", "l": "Caspase-mediated cleavage of GAS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38677", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46782", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18326", "l": "(2E,6E)-farnesyl diphosphate => (+)-amorpha-4,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22180", "l": "(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17873", "l": "an R-cob(III)alamin(out) + ATP + H2O = ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.8", "l": "\"ABC-type vitamin B12 transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010396", "l": "SLIT1 binds COL4A5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106367", "l": "(deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP."], "t": []}, {"i": "RHEA:62128", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15938", "l": "a primary alcohol + NADP(+) => an aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20690", "l": "chlorogenate + H2O => (E)-caffeate + H(+) + L-quinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701199", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853793", "l": "p-5Y-RET complexes bind GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58849", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-hydroxygeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40918", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38233", "l": "1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA => (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18578", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25790", "l": "pyruvate + succinate semialdehyde => 4-hydroxy-2-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77037", "l": "H(+) + heptan-2-one + NADH + NH4(+) => (2S)-heptan-2-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210277", "l": "Interaction of PECAM-1 and SHP-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211191", "l": "Association of DFF with alpha:beta importin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76171", "l": "glycyl-L-lysine(out) + 2 H(+)(out) = glycyl-L-lysine(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008111", "l": "alpha-methylacyl-CoA racemase activity", "d": ["Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21674", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12473", "l": "H2O + N-ethylglycine + O2 => ethylamine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592398", "l": "Activation of proMMP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68653", "l": "2 L-homocysteine => H(+) + hydrogen sulfide + L-homolanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10858", "l": "a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36262", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol <=> an aldehyde + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22709", "l": "H2O + S-acylglutathione => a carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001002", "l": "RNA polymerase III type 1 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55247", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3364014", "l": "Recruitment of SET1 methyltransferase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12802", "l": "ATP + L-seryl-[tau protein] => ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77189", "l": "beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+) => beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102297", "l": "selenate adenylyltransferase activity", "d": ["Catalysis of the reaction: selenic acid + ATP + 2 H+ = adenylyl selenate + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74662", "l": "N-acetyl-D-glucosamine + UTP <=> H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54215", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45593", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36407", "l": "ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate", "d": [], "t": []}, {"i": "EC:2.7.7.87", "l": "\"L-threonylcarbamoyladenylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850961", "l": "PREX2 binds PTEN and inhibits it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102130", "l": "malonyl-CoA methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042021", "l": "granulocyte macrophage colony-stimulating factor complex binding", "d": ["Binding to a granulocyte macrophage colony-stimulating factor complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39306", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA <=> (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050251", "l": "retinol isomerase activity", "d": ["Catalysis of the reaction: all-trans-retinol = 11-cis-retinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37569", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43348", "l": "cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53694", "l": "H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0019118", "l": "phenanthrene-epoxide hydrolase activity", "d": ["Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67101", "l": "fumigatonoid B => fumigatonoid C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43428", "l": "1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.45", "l": "\"melamine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102644", "l": "monocyclic sesterterpenediol synthase activity", "d": ["Catalysis of the reaction: monocyclic sesterterpenediol = all-trans-geranylfarnesol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762246", "l": "ANGPTL4 binds CDH11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13834", "l": "L-arginine + pyruvate => 5-guanidino-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963915", "l": "1,25(OH)2D binds VDR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034922", "l": "4,5-dihydroxypyrene dioxygenase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54823", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50385", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline => 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40555", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.187", "l": "\"L-evernosamine nitrososynthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33888", "l": "(-)-secoisolariciresinol + 2 NAD(+) => (-)-matairesinol + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24082", "l": "AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp) => ATP + L-tryptophan + tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42057", "l": "13-cis-retinol + NAD(+) => 13-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21628", "l": "17alpha-hydroxyprogesterone + NADPH + O2 = acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13087", "l": "CoA + L-2-acetamido-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052926", "l": "dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63577", "l": "ecdysone 22-phosphate + H2O => ecdysone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835358", "l": "p-TARBP2 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17752", "l": "A + H2O + quinoline <=> AH2 + quinolin-2(1H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60379", "l": "D-glucose(out) <=> D-glucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51454", "l": "beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043744", "l": "N2-acetyl-L-aminoadipate kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869683", "l": "oxPL binds LBP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72641", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35534", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 <=> albonoursin + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60616", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine = ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38255", "l": "(S)-malate + succinyl-CoA = (S)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47063", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38649", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41313", "l": "1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791109", "l": "GADD45A binds PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.110", "l": "\"sterigmatocystin 8-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18452", "l": "A + arsenite + H2O <=> AH2 + arsenate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432067", "l": "Aquaporin-4 passively transports water out of cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622415", "l": "RIP2 binds NEMO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22465", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37436", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25553", "l": "9alpha-copalyl diphosphate => diphosphate + stemar-13-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863472", "l": "DAB2 binds LRP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052671", "l": "geranylgeraniol kinase activity", "d": ["Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35208", "l": "H2O + IDP => H(+) + IMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791157", "l": "Expression of DNAJC3 (p58IPK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58076", "l": "1-(11Z-eicosenoyl)-glycerol + H2O = (11Z)-eicosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.59", "l": "\"mitochondrial intermediate peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449200", "l": "Interaction of ABL1 with CDO complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30673", "l": "2 N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004574", "l": "oligo-1,6-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52301", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912734", "l": "CBL:CRKL binds RAPGEF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944254", "l": "Association of procollagen type XXVI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30689", "l": "glyoxylate + pyruvate => (4R)-4-hydroxy-2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50719", "l": "dimethyl sulfone + FMNH2 + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50650", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 2-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296043", "l": "Activation of HCN channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432164", "l": "Ca2+ influx into the post-synaptic cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45191", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73212", "l": "H(+)(in) + sucrose(out) => H(+)(out) + sucrose(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62606", "l": "7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047928", "l": "gibberellin beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72889", "l": "ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + polyporic acid + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68520", "l": "(2E,6E)-farnesyl diphosphate = beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39177", "l": "(2E)-eicosenoyl-CoA + H2O => (3R)-hydroxyeicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70127", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59417", "l": "H2O + O2 + tryptamine => H2O2 + indole-3-acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13199", "l": "H2O + UDP-alpha-D-6-sulfoquinovose => H(+) + sulfite + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018627", "l": "2-aminobenzenesulfonate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74674", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) <=> UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47156", "l": "7alpha,25-dihydroxycholesterol + NAD(+) = 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39872", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 3-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120233", "l": "prenyl-FMNH2 binding", "d": ["Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209828", "l": "Tryptophan is hydroxylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168046", "l": "Collagen type XII degradation by MMP12 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426032", "l": "DAG is metabolized by DAGL to 2-AG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41747", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529020", "l": "CK2 phosphorylates condensin I subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314678", "l": "ASA- acetylates PTGS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12934", "l": "L-fuculose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61782", "l": "keto-L-sorbose => keto-L-tagatose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928639", "l": "p-EFNB binds GRB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42633", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247837", "l": "WNT ligands traffic to the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39486", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640862", "l": "Tankyrase binds AXIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24592", "l": "CTP + H(+) + phosphoethanolamine = CDP-ethanolamine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.14", "l": "\"ethanolamine-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40294", "l": "ATP + CoA + tetradecanedioate <=> AMP + diphosphate + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14425", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.68", "l": "\"1-phosphatidylinositol-4-phosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73873", "l": "(R)-noradrenaline(in) => (R)-noradrenaline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944214", "l": "Association of procollagen type I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166869", "l": "TRAF6 binds MEKK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72577", "l": "(22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37978", "l": "H(+) + homogentisate + phytyl diphosphate <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687079", "l": "IGF2BP1 binds MAPK4 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9621179", "l": "Cinaciguat binds sGC:NO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804099", "l": "HMGB1 binds LTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45226", "l": "(2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12792", "l": "an alditol + NADP(+) <=> an aldose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807826", "l": "LDHAL6B reduces PYR to LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809521", "l": "BPIF binds bacteria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.-", "l": "\"In cyclic amides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106437", "l": "protein-glutamic acid ligase activity, initiating", "d": ["Catalytic reaction: ATP + L-glutamate + L-glutamyl-[protein] = ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate."], "t": []}, {"i": "RHEA:60144", "l": "ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34722", "l": "15-methylhexadecasphing-4-enine 1-phosphate <=> (2E)-13-methyltetradecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21303", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.3", "l": "\"plant seed peroxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13691", "l": "glycerol 1-phosphate + H(+) + phosphate => diphosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38217", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADH => D-glucose 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21112", "l": "a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": [], "t": []}, {"i": "EC:3.2.1.22", "l": "\"alpha-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028505", "l": "Activated NTRK2 recruits PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.144", "l": "\"geranyllinalool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183051", "l": "CBL ubiquitinates Sprouty (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55496", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25975", "l": "H2O + N(8)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58192", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin = dihydrobisanhydrobacterioruberin + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203973", "l": "Vesicle budding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59092", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose = [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}, {"i": "EC:2.4.1.372", "l": "\"mutansucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944240", "l": "Association of procollagen type III (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51327", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72186", "l": "creatinine(in) + H(+)(out) <=> creatinine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32694", "l": "(2E)-geranyl diphosphate <=> (E)-beta-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65457", "l": "2-methylbutan-1-ol + acetyl-CoA => 2-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29012", "l": "2-oxoglutarate(in) + H(+)(in) => 2-oxoglutarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71863", "l": "taurodeoxycholate(out) = taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114440", "l": "Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43554", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41277", "l": "eicosanoate + sphing-4-enine => H2O + N-eicosanoyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102255", "l": "neo-lambda-carrahexaose hydrolase activity", "d": ["Catalysis of the reaction: neo-lambda-carrahexaose + H2O = neo-lambda-carratetraose + neo-lambda-carrabiose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810843", "l": "Envoplakin binds periplakin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661230", "l": "MT1A binds arsenic (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004120", "l": "photoreceptor cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014293", "l": "RAC2 GDIs block activation of RAC2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432593", "l": "Cytosolic JET binds to CRY, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73989", "l": "diphosphate + discoidol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23536", "l": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450348", "l": "Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022849", "l": "glutamate-gated calcium ion channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64147", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine <=> (9Z)-octadecenoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26425", "l": "3'-phosphoadenylyl sulfate + thyroxine <=> adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43176", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.310", "l": "\"25S rRNA (cytosine(2870)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193767", "l": "Influx of 24-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.337", "l": "\"L-2-hydroxycarboxylate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5229343", "l": "AXIN is phosphorylated in the destruction complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15501", "l": "2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": [], "t": []}, {"i": "EC:1.4.1.13", "l": "\"glutamate synthase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193668", "l": "p75NTR and RHOA-GDI interact (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33979", "l": "DIBOA beta-D-glucoside + H2O = D-glucose + DIBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043748", "l": "O-succinylbenzoate synthase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate."], "t": []}, {"i": "RHEA:10196", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.113", "l": "\"o-succinylbenzoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654422", "l": "Activated FGFR4 binds FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102692", "l": "benzyladenine UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine = H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10180", "l": "(6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.6", "l": "\"formyltetrahydrofolate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48141", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51344", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34004", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 => 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21948", "l": "formamide + H2O = formate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.49", "l": "\"formamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.75", "l": "\"glucan endo-1,6-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200396", "l": "Creatine transport across the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24541", "l": "A + D-glucose => AH2 + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74791", "l": "(R)-salsolinol(in) = (R)-salsolinol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46775", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35225", "l": "2-oxo-dAMP + H(+) + phosphate => 2-oxo-dADP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34810", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59994", "l": "(E)-4-coumarate + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + phloretate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052901", "l": "spermine:oxygen oxidoreductase (spermidine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110322", "l": "Formation of Pol zeta complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31327", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol = bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.34", "l": "\"CDP-L-myo-inositol myo-inositolphosphotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071424", "l": "rRNA (cytosine-N4-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}, {"i": "RHEA:62520", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13904", "l": "H2O + N-(aminomethyl)urea <=> N-(hydroxymethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72886", "l": "2 3-phenylpyruvate + 2 ATP <=> 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30100", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.108", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23695", "l": "(R)-malate <=> H2O + maleate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45942", "l": "4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186798", "l": "GAP binds to PDGF-beta receptors only (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52205", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42586", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0097027", "l": "ubiquitin-protein transferase activator activity", "d": ["Binds to and increases the activity of a ubiquitin-protein transferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021596", "l": "Membrane estrogen receptors bind SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18362", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73389", "l": "H(+)(out) + malonate(in) + phosphate(out) => H(+)(in) + malonate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56762", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32812", "l": "benzoate(in) => benzoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77709", "l": "3',3'-cGMP-UMP + 2 diphosphate => GTP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51726", "l": "adenosine 5'-tetraphosphate + ADP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13433", "l": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754129", "l": "CDK6 inhibitors bind CDK6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33452", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] => AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804402", "l": "TP53 binds POU4F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218811", "l": "DOCK180:ELMO binds CRK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44582", "l": "2-all-trans-decaprenylphenol + CO2 => 4-hydroxy-3-all-trans-decaprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14180", "l": "(R)-amygdalin + H2O <=> (R)-prunasin + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20407", "l": "(2S,6S)-2,6-diaminoheptanedioate + acetate => H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691174", "l": "RAC1 binds effectors at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17185", "l": "IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.7.1.7", "l": "\"GMP reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17944", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36039", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031996", "l": "thioesterase binding", "d": ["Binding to a thioesterase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757954", "l": "N4BP1 binds IKBKG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374919", "l": "Noradrenaline clearance from the synaptic cleft (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69127", "l": "Formation of the Flap Intermediate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112429", "l": "Formation of FACT complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691150", "l": "TFR2 dimer binds 2xholoTF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000334", "l": "3-hydroxyanthranilate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + O2 = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27416", "l": "2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855189", "l": "I(1,4,5,6)P4 transports from the ER lumen to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72106", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850797", "l": "SPINK6 binds KLK13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31114", "l": "acetyl-CoA + butanoyl-CoA <=> 3-oxohexanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70147", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873927", "l": "Release of STAT1 dimer from active receptor unit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16040", "l": "phosphate + thymidine <=> 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160106", "l": "tRNA (adenine(9)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60676", "l": "(S)-(-)-citronellol + NAD(+) = (S)-(-)-citronellal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22630", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0005231", "l": "excitatory extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69530", "l": "4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+) => chorismate + H2O + 2 L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23273", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose => an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179413", "l": "Activated PKC-alpha  activate MMP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42896", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.297", "l": "\"peptide chain release factor N(5)-glutamine methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444100", "l": "PROT mediates L-proline uptake (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15915", "l": "ADP + thiamine diphosphate => ATP + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61755", "l": "steviolbioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside B + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48057", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => beta-D-glucosylceramide + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687109", "l": "8b binds MAP1LC3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937118", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40517", "l": "(2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate => 6-deoxy-6-sulfo-D-fructose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236949", "l": "Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047791", "l": "cucurbitacin delta23-reductase activity", "d": ["Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692755", "l": "CDK1 phosphorylates MAPK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42766", "l": "CO2 + reduced coenzyme F420-(gamma-L-Glu)(n) => formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693356", "l": "CEMIP hydrolyses HA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73067", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": [], "t": []}, {"i": "EC:3.2.1.96", "l": "\"mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52144", "l": "3-phosphonopyruvate + acetyl-CoA + H2O = (R)-2-(phosphonomethyl)malate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.19", "l": "\"2-phosphonomethylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48310", "l": "(3Z)-6-oxohex-3-enoyl-CoA + formate + H(+) => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60347", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390909", "l": "HRH2 binds hist (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428625", "l": "Vesicular inhibitory amino acid transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53083", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28422", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52975", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875451", "l": "MET phosphorylates CBL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627350", "l": "SMAC (DIABLO) binds XIAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939204", "l": "ESTG binds ESR1:chaperone complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183051", "l": "CBL ubiquitinates Sprouty (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14850", "l": "H2O + N-amidino-L-aspartate => L-aspartate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40539", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796617", "l": "MIB2 binds CFLAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977629", "l": "Displacement of C2a/Bb by CR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.4", "l": "\"purine imidazole-ring cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73166", "l": "FAD(out) + NAD(+)(in) <=> FAD(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052614", "l": "uracil oxygenase activity", "d": ["Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.39", "l": "\"plasmepsin II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008184", "l": "glycogen phosphorylase activity", "d": ["Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043909", "l": "N-acetylcitrulline deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate."], "t": []}, {"i": "RHEA:61092", "l": "H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39808", "l": "octadecanoate(in) => octadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29991", "l": "H(+)(in) + L-lyxopyranose(in) = H(+)(out) + L-lyxopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47931", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9703895", "l": "CASR binds CASR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004509", "l": "steroid 21-monooxygenase activity", "d": ["Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35545", "l": "3-hydroxypyruvate + phosphate => 3-phosphooxypyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.8", "l": "\"4-hydroxy-tetrahydrodipicolinate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48530", "l": "a ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate => a ganglioside GP1c (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37812", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37446", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23388", "l": "ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.119", "l": "\"hygromycin-B 7''-O-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15826", "l": "AZD1979 + H2O => AZD1979 oxetane hydrolysis product + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10120", "l": "adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.37", "l": "\"double-stranded RNA adenine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43755", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19237", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": [], "t": []}, {"i": "EC:5.4.99.14", "l": "\"4-carboxymethyl-4-methylbutenolide mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64660", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31837", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514823", "l": "Fibrillin-1 degradation by ELANE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30308", "l": "7-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55950", "l": "AH2 + NH4(+) + pyruvate => A + D-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30248", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 => O2 + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0099186", "l": "structural constituent of postsynapse", "d": ["The action of a molecule that contributes to the structural integrity of a postsynapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63774", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "45.834884486543203", "identifiers": [{"i": "GO:0022803", "l": "passive transmembrane transporter activity", "d": ["Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681980", "l": "ATG12 binds ATG7 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54340", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950456", "l": "IL12B dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35885", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45207", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol <=> H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611839", "l": "β3-agonists bind ADRB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54324", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56957", "l": "ITP + pyruvate => H(+) + IDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928656", "l": "gamma-secretase cleaves EPHB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65320", "l": "2-oxoglutarate + chrodrimanin E + O2 = chrodrimanin A + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030750", "l": "putrescine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27581", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + tert-butylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43550", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25332", "l": "3-dehydrocarnitine + H(+) + NADH => (R)-carnitine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73217", "l": "sulfate(in) + thiosulfate(out) => sulfate(out) + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637770", "l": "Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33363", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.197", "l": "\"protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76680", "l": "CoA + NAD(+) + sulfoacetaldehyde => H(+) + NADH + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052595", "l": "aliphatic amine oxidase activity", "d": ["Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686587", "l": "ABL1 phosphorylates RAD52 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449855", "l": "IL10 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19078", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63393", "l": "A + Fe(II)-heme o + H2O => AH2 + Fe(II)-heme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29078", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 <=> CO2(out) + H(+)(out) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141046", "l": "Atg8-family conjugating enzyme activity", "d": ["Isoenergetic transfer of an Atg8 family modifer from one protein to a phosphatidylethanolamine or phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47011", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36648", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681294", "l": "IL6R binds IL6R inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71163", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) = H(+)(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473584", "l": "Collagen type III degradation by MMP15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791150", "l": "Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001874", "l": "(1->3)-beta-D-glucan immune receptor activity", "d": ["Combining with (1->3)-beta-D-glucans to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54786", "l": "Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68589", "l": "(6R)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine => (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46372", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50561", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964531", "l": "TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757256", "l": "MCM3 binds MCM5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21064", "l": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide", "d": [], "t": []}, {"i": "EC:1.8.4.2", "l": "\"protein-disulfide reductase (glutathione)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140217", "l": "Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49447", "l": "(2-aminobenzoyl)acetyl-CoA + H2O <=> (2-aminobenzoyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57612", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH = 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798749", "l": "Exocytosis of specific granule lumen proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351208", "l": "Spermidine  => N-acetylated spermidine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400282", "l": "CRY proteins are ubiquitinylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72982", "l": "didemethylasterriquinone D + dimethylallyl diphosphate <=> asterriquinone C1 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63085", "l": "chloride + FADH2 + ilicicolin B + O2 => FAD + H(+) + 2 H2O + ilicicolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50616", "l": "NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55437", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77068", "l": "Activation of GT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69113", "l": "glyoxylate + L-2-aminoadipate => 2-oxoadipate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26288", "l": "Co-precorrin-5B + S-adenosyl-L-methionine <=> Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53697", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019871", "l": "sodium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a sodium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.5", "l": "\"L-threonine aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19151", "l": "H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13575", "l": "[(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74340", "l": "O-3-methylbutanoyl-(R)-carnitine(in) => O-3-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35802", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32655", "l": "a carboxylate + eugenol + NADP(+) = a coniferyl ester + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42013", "l": "cortisol + NAD(+) => 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45752", "l": "(3E)-decenoyl-CoA = (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549060", "l": "NrCAM binds Neuropilin-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46345", "l": "propanoyl-CoA + tetradecanoyl-CoA => 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-706479", "l": "TAK1 is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31140", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847968", "l": "PTEN binds FRK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712190", "l": "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23584", "l": "7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.12", "l": "\"dihydrofolate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869580", "l": "DEK binds TFAP2A homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54280", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482860", "l": "DLCL transports from the IM to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70718", "l": "glycine(in) <=> glycine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44709", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734578", "l": "GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31530", "l": "N(omega)-hydroxy-L-arginine <=> guanidine + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237160", "l": "MTA is cleaved and phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038944", "l": "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66060", "l": "2-oxohexanoate + L-kynurenine = H2O + kynurenate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67275", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.40", "l": "\"anthraniloyl-CoA monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68619", "l": "cortisone + H(+) + NADPH <=> cortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38203", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102357", "l": "mithramycin dehydrogenase activity", "d": ["Catalysis of the reaction: mithramycin + NADP = mithramycin DK + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849878", "l": "PSD-95 binds NMDA receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64346", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+) => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55926", "l": "albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51067", "l": "3'-phosphoadenylyl sulfate + lithocholate <=> adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13285", "l": "ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.2", "l": "\"glutamate--cysteine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683792", "l": "p-T68-CHEK2 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654515", "l": "KAL1 binds HS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55963", "l": "4-(trimethylamino)butanoate + ATP + CoA <=> 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013145", "l": "RAC1 binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35196", "l": "L-quinate(in) => L-quinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70771", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139899", "l": "Sequestration of BAD protein by 14-3-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696268", "l": "RND3 binds effectors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704297", "l": "CHRM2 binds CHRM2 antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26059", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:2.1.1.248", "l": "\"[methylamine--corrinoid protein] Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51200", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine = H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1006143", "l": "CD46 binds C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28103", "l": "GDP-alpha-D-mannose + H2O => D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25231", "l": "H(+) + L-arabinose + NADPH => L-arabinitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30487", "l": "H(+) + N,N-dihydroxy-L-isoleucine = (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31796", "l": "(+)-(E)-beta-caryophyllene + H2O => (+)-caryolan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67502", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52712", "l": "dTMP + H2O = 2-deoxy-D-ribose 5-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004153", "l": "dihydropterin deaminase activity", "d": ["Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20496", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38554", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37516", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39129", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59618", "l": "beta-alanine + L-arginine => beta-alanyl-L-arginine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28570", "l": "ATP + L-serine = diphosphate + L-seryl-5'-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32068", "l": "8-oxoguanine + H(+) + H2O => NH4(+) + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64920", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008098", "l": "5S rRNA primary transcript binding", "d": ["Binding to an unprocessed 5S ribosomal RNA transcript."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-190141", "l": "ALAD binds to Pb2+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37537", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63917", "l": "5-fluorouridine + ATP => 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75407", "l": "2-dehydro-D-glucose = cortalcerone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904047", "l": "S-adenosyl-L-methionine binding", "d": ["Binding to S-adenosyl-L-methionine."], "t": []}, {"i": "REACT:R-HSA-947535", "l": "Cyclisation of GTP to precursor Z (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111970", "l": "PKC phosphorylates GRK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25000", "l": "H(+) + N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047663", "l": "aminoglycoside 6'-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H+. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22443", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61876", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021596", "l": "Membrane estrogen receptors bind SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31026", "l": "squalene <=> dammara-20,24-diene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50559", "l": "prostaglandin D2 <=> H2O + prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33960", "l": "2-oxoglutarate + neomycin C => 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64705", "l": "diphenylmethanol + NAD(+) => benzophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52138", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+) => a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41263", "l": "NAD(+) + prostaglandin A1 = 15-oxo-prostaglandin A1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38309", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848864", "l": "PTK6 binds ARAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76571", "l": "4-deoxy-L-erythro-hex-4-enopyranuronate = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77514", "l": "2-methoxybenzaldehyde + hydrogen cyanide <=> (2S)-2-hydroxy-2-(2-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39381", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30643", "l": "phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.2.44", "l": "\"S-methyl-5'-thioinosine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29848", "l": "(2E)-tetradecenoyl-CoA => (3Z)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73040", "l": "H(+)(out) + Ni(2+)(out) => H(+)(in) + Ni(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24269", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47569", "l": "a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose => a ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18146", "l": "ATP + beta-D-fructose => ADP + beta-D-fructose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41877", "l": "(3R)-hydroxydodecanoyl-[ACP] => (2E)-dodecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68439", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 <=> (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70116", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45987", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43746", "l": "AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2) => ATP + cytidine(34) in tRNA(Ile2) + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.820554254294692", "identifiers": [{"i": "GO:0022824", "l": "transmitter-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015439", "l": "ABC-type heme transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24197", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48181", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23699", "l": "myo-inositol + O2 <=> D-glucuronate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299359", "l": "Activation of TALK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12216", "l": "9H-fluoren-9-ol + NAD(+) = 9H-fluoren-9-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.421949063212963", "identifiers": [{"i": "GO:0030545", "l": "signaling receptor regulator activity", "d": ["Binds to and modulates the activity of a receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69090", "l": "butanoate + 2 H(+) + NADH => butanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690873", "l": "ACO1 binds 4Fe-4S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004062", "l": "aryl sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71947", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) = N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0009982", "l": "pseudouridine synthase activity", "d": ["Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37064", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809254", "l": "MTMR8 binds MTMR9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13773", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.64", "l": "\"(S)-stylopine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607722", "l": "Active NIK phosphorylates IKKA dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44664", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050566", "l": "asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418662", "l": "Src activation following P2Y purinoceptor activation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14215", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016218", "l": "polyketide synthase activity", "d": ["Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-706479", "l": "TAK1 is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102014", "l": "beta-D-galactose-importing ATPase activity", "d": ["Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O = ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24524", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.34", "l": "\"20-oxo-5-O-mycaminosyltylactone 23-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59059", "l": "2 methanethiol + NAD(+) <=> dimethyl disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56332", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O = AMP + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665761", "l": "FMNL3 binds RHOC:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193753", "l": "3,7,24THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74931", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 = a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42911", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA <=> 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76503", "l": "4-O-beta-D-glucosyl-trans-ferulate + H2O = 4-O-beta-D-glucosyl-vanillin + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13554", "l": "alpha-D-galactose + ATP => ADP + alpha-D-galactose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050610", "l": "methylarsonate reductase activity", "d": ["Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62373", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59420", "l": "H2O + methylamine + O2 = formaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201457", "l": "BMP2 binds to the receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004145", "l": "diamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679775", "l": "COMT binds COMT Inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950456", "l": "IL12B dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641134", "l": "SMURF2 binds AXIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013021", "l": "GDIs block activation of RHOB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008478", "l": "pyridoxal kinase activity", "d": ["Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391936", "l": "EP1 receptor can bind PGE2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204863", "l": "Interaction of Tie2 with Ang2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64344", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 = 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170015", "l": "carbon dioxide receptor activity", "d": ["Combining with carbon dioxide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57231", "l": "GDP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69682", "l": "apigenin 7-O-beta-D-glucoside + H2O <=> apigenin + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937654", "l": "IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51502", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => ATP + N-acetyl-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41408", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446372", "l": "Association of  PARVA with TESK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22738", "l": "(6R)-5,10-methenyltetrahydrofolate + NH4(+) => 5-formimidoyltetrahydrofolate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217150", "l": "Monoubiquitination of FancD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836275", "l": "TFAP2A binds TFAP2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694421", "l": "PP6 dephosphorylates SEC24 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73640", "l": "CTP(out) + ITP(in) => CTP(in) + ITP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62878", "l": "A + semiviriditoxin => AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59048", "l": "D-ornithine + H(+) = CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047311", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity", "d": ["Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72523", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701549", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31128", "l": "3-O-methylgallate + O2 => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74120", "l": "delphinidin + UDP-alpha-D-galactose => delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50290", "l": "(8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32478", "l": "glycine + 3 S-adenosyl-L-methionine <=> glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69398", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52615", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15391", "l": "3',5'-cyclic AMP + diphosphate => ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22821", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52062", "l": "(9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47018", "l": "[DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018498", "l": "2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.170", "l": "\"2-(omega-methylthio)alkylmalate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13494", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57999", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43069", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28088", "l": "2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate => 2 H2O2 + Reactive Blue 5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5195402", "l": "CDK1 phosphorylates LPIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672980", "l": "Dissociation of RAS:RAF complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685606", "l": "CLEC2D binds KLRB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54336", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006850", "l": "IL21 receptor JAK phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5220959", "l": "TDG excises 5-formylcytosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0060072", "l": "large conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296045", "l": "Activation of Potassium transport channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418200", "l": "SRC-1 bound to ARRB2 is not activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70362", "l": "3-oxosphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48384", "l": "a 2,3-saturated fatty acid + H2O2 = a 3-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731018", "l": "SARS-CoV-1 M binds to PDPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66216", "l": "asc-C7-CoA + O2 = asc-DeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25465", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + longifolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43317", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912357", "l": "ITCH ubiquitinates DTX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034000", "l": "chondroitin-sulfate-ABC endolyase activity", "d": ["Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75599", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = ectocarpin A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50042", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40717", "l": "1-hexadecanoylglycerone 3-phosphate + CoA => dihydroxyacetone phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018667", "l": "cyclohexanone monooxygenase activity", "d": ["Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694583", "l": "ABHD4 hydrolyses NAPE (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50224", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30194", "l": "15-cis-phytoene + plastoquinone-9 <=> 15,9'-di-cis-phytofluene + plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22837", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48352", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74962", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] <=> (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64090", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O => acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635843", "l": "GLI translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13961", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": [], "t": []}, {"i": "EC:6.6.1.1", "l": "\"magnesium chelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202203", "l": "Recruitment of PI3K to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061632", "l": "RNA lariat debranching enzyme activator activity", "d": ["Binds to and increases the activity of an RNA lariat debranching enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160105", "l": "tRNA (adenine(22)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964274", "l": "G alpha (12) binds BTK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29411", "l": "glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38751", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42607", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76307", "l": "L-aspartate(in) + L-glutamate(out) = L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26048", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004414", "l": "homoserine O-acetyltransferase activity", "d": ["Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102643", "l": "scalarane-17alpha-19-diol synthase activity", "d": ["Catalysis of the reaction: scalarane-17alpha-19-diol = all-trans-geranylfarnesol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19455", "l": "L-glutamate + pyruvate => 2-oxoglutarate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43794", "l": "H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(645) in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004475", "l": "mannose-1-phosphate guanylyltransferase (GTP) activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54828", "l": "dimethylamine + H(+) + NADPH + O2 = formaldehyde + H2O + methylamine + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.238", "l": "\"dimethylamine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48319", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690023", "l": "NUBPL binds 4Fe-4S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18559", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32750", "l": "ethanolamine(in) <=> ethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167419", "l": "The receptor:G-protein complex releases GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3321805", "l": "NSL acetylates histone H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20931", "l": "[DsbA protein]-dithiol + a quinone <=> [DsbA protein]-disulfide + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76558", "l": "ergosterol + L-aspartyl-tRNA(Asp) <=> 1-(ergostan-3beta-yl)-L-aspartate + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11382", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate => 2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55081", "l": "ADP-alpha-D-glucose + D-fructose => ADP + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24843", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64376", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16104", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13191", "l": "3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030770", "l": "demethylmacrocin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H+ + macrocin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43194", "l": "2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19254", "l": "a sphingomyelin + H2O => an N-acylsphing-4-enine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63223", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624954", "l": "INPP5E translocates to the primary cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22584", "l": "2 H(+) + heme b = Fe(2+) + protoporphyrin IX", "d": [], "t": []}, {"i": "EC:4.98.1.1", "l": "\"protoporphyrin ferrochelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685319", "l": "CX3 complex formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201691", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692135", "l": "SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788623", "l": "p-Y-STATs translocate to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19095", "l": "12,18-didecarboxysiroheme + 2 CO2 => 2 H(+) + siroheme", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64358", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O => 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061690", "l": "lipoamidase activity", "d": ["Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0016289", "l": "acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003947", "l": "(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64437", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) => glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17519", "l": "a long-chain fatty acid + L-glutamate => H2O + N-(long-chain-fatty-acyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591052", "l": "PROCR binds Protein C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805399", "l": "TAF1 phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785768", "l": "MRN complex binds DNA double strand breaks (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42436", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.194", "l": "\"protein-N(pi)-phosphohistidine--L-ascorbate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853496", "l": "SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74664", "l": "acetylcholine(in) => acetylcholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54183", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168886", "l": "Hemopexin binds Hemes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43405", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46744", "l": "ATP + hydrogencarbonate = ADP + carboxyphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61833", "l": "sitosterol + UDP-alpha-D-glucose => H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65033", "l": "3 a quinone + protoporphyrinogen IX => 3 a quinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762102", "l": "NICD1 binds the NFE2L2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213207", "l": "Formation of collagen networks (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072346", "l": "cADPR-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16811", "l": "pyruvate + succinate => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29038", "l": "ATP + H2O + L-glutamate(out) <=> ADP + H(+) + L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707856", "l": "PGRMC2:Hemes dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43413", "l": "a D-galactosylceramide + H2O => an N-acyl-sphingoid base + D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987120", "l": "JAK1 binds IFNLR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29417", "l": "(S)-lactate(out) + H(+)(out) => (S)-lactate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29325", "l": "fumarate(out) + succinate(in) => fumarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32356", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + 2 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40989", "l": "ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O => EDTA + 2 FMNH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46353", "l": "(2E)-decenoyl-CoA + H2O => 3-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193641", "l": "IKK-beta is recruited (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68615", "l": "Formation of ORC(1-6) complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12119", "l": "A + H2 <=> AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31807", "l": "(2E,6E)-farnesyl diphosphate = alpha-guaiene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.87", "l": "\"alpha-guaiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427570", "l": "Group 3 - Selective Cl- transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659926", "l": "Defective SI does not hydrolyze Suc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726949", "l": "PTGIR binds PTGIR agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19496", "l": "D-cellobiose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59660", "l": "D-cellotetraose + O2 = D-cellotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29004", "l": "H(+)(out) + L-homoserine(in) => H(+)(in) + L-homoserine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186780", "l": "PI3-kinase binds to the active receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66346", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55272", "l": "11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68524", "l": "(2Z,6Z)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018774", "l": "2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity", "d": ["Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53398", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) => a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68222", "l": "(7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871266", "l": "YAP1 binds TEAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218821", "l": "PDK1 phosphorylates PKC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786101", "l": "IL4 binds IL4R:JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53507", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9671145", "l": "DKC1 binds SHQ1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57275", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68813", "l": "(2Z,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41428", "l": "L-tyrosine + S-adenosyl-L-methionine = 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.304", "l": "\"L-tyrosine C(3)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37722", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73444", "l": "2-oxoglutarate + gardenin B + O2 => CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38957", "l": "an N-acylsphing-4-enine 1-phosphate(out) => an N-acylsphing-4-enine 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950322", "l": "Expression of ribosomal protein lateral stalk subunit P0 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68657", "l": "7-oxocholesterol + H(+) + NADPH => 7beta-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014296", "l": "RAC2 GEFs activate RAC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31483", "l": "soyasapogenol E + UDP-alpha-D-glucuronate = H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043426", "l": "MRF binding", "d": ["Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102452", "l": "bisdemethoxycurcumin synthase activity", "d": ["Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ = 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24210", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-mannitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13423", "l": "an N-acylneuraminate 9-phosphate + phosphate => an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33973", "l": "phosphate + ribostamycin => 5''-phosphoribostamycin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39504", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47582", "l": "a ganglioside GT2 (d18:1(4E)) + H(+) + UDP => a ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28703", "l": "Cu(2+)(in) = Cu(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977301", "l": "Histidine is decarboxylated to histamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102102", "l": "homocarnosine synthase activity", "d": ["Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18625", "l": "D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49307", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33181", "l": "1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14201", "l": "D-lyxose = D-xylulose", "d": [], "t": []}, {"i": "EC:5.3.1.15", "l": "\"D-lyxose ketol-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18597", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] = NADH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015138", "l": "fumarate transmembrane transporter activity", "d": ["Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990634", "l": "protein phosphatase 5 binding", "d": ["Binding to protein phosphatase 5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015386", "l": "potassium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)."], "t": []}, {"i": "RHEA:29467", "l": "H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73058", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) <=> estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30553", "l": "6-O-acetyl-beta-D-glucose + CoA => acetyl-CoA + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.43270433472901", "identifiers": [{"i": "GO:0004553", "l": "hydrolase activity, hydrolyzing O-glycosyl compounds", "d": ["Catalysis of the hydrolysis of any O-glycosyl bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785898", "l": "IL4R binds JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-532549", "l": "MPI isomerises Fru6P to Man6P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25896", "l": "H(+) + malonate = acetate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.88", "l": "\"biotin-independent malonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52887", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) <=> 2 H(+) + 2 NADPH + nitrobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160153", "l": "mitochondrial tRNA pseudouridine(27/28) synthase activity", "d": ["Catalysis of the reaction: uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047915", "l": "ganglioside galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60009", "l": "a tRNA precursor + 2 CTP => a tRNA with a 3' CC end + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61111", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69068", "l": "RFC dissociates after sliding clamp formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65173", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O => (3Z,5E)-dodecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47341", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72185", "l": "mRNA polyadenylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443894", "l": "TXA2 is hydrolysed to TXB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981658", "l": "Complement factor I binds C4BP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.66", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59939", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12837", "l": "ATP + choline = ADP + H(+) + phosphocholine", "d": [], "t": []}, {"i": "EC:2.7.1.32", "l": "\"choline kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769115", "l": "MAPK1,(MAPK3) phosphorylates NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31011", "l": "(S)-2,3-epoxysqualene = camelliol C", "d": [], "t": []}, {"i": "EC:5.4.99.38", "l": "\"camelliol C synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008745", "l": "N-acetylmuramoyl-L-alanine amidase activity", "d": ["Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418456", "l": "cGMP is degraded by PDEs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47082", "l": "17beta-hydroxy-5beta-estran-3-one + NADP(+) => 17beta-hydroxyestr-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47155", "l": "2,5-dioxopentanoate + H2O + NAD(+) <=> 2-oxoglutarate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76708", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061634", "l": "alpha-D-xyloside xylohydrolase", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose."], "t": []}, {"i": "EC:3.2.1.177", "l": "\"alpha-D-xyloside xylohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664983", "l": "Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76155", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45464", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.10", "l": "\"icosanoyl-CoA 5-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53352", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) = H(+) + NADH + uridine(20b) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60223", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31636", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O => 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49156", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018461", "l": "fluoren-9-ol dehydrogenase activity", "d": ["Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74448", "l": "Calcium binds calmodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982617", "l": "CYGB:O2 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62548", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.-", "l": "\"Oxygenases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10371", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071796", "l": "K6-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42775", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47231", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25064", "l": "3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53165", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57879", "l": "uridine(54) in tRNA <=> pseudouridine(54) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761474", "l": "AMOT-2 binds CDH11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018798", "l": "RHOV binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483174", "l": "PE is methylated to PC by PEMT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56309", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665696", "l": "ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33120", "l": "(2E,6E)-farnesyl diphosphate => (+)-sativene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12689", "l": "2 mycothiol + NAD(+) = H(+) + mycothione + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628756", "l": "NEIL1 G83D does not cleave FapyA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9704297", "l": "CHRM2 binds CHRM2 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017797", "l": "NOTCH3 binds YBX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37471", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.3.1.228", "l": "\"isovaleryl-homoserine lactone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68097", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.-.-", "l": "\"Acting on carbon-nitrogen bonds, other than peptide bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30659", "l": "4-(phosphooxy)-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047868", "l": "dimethylmaleate hydratase activity", "d": ["Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68355", "l": "pppA(2'-5')pG <=> 3',2'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690873", "l": "ACO1 binds 4Fe-4S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030172", "l": "troponin C binding", "d": ["Binding to troponin C, the calcium-binding subunit of the troponin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004690", "l": "cyclic nucleotide-dependent protein kinase activity", "d": ["cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61814", "l": "dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47368", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.345", "l": "\"phosphatidyl-myo-inositol alpha-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928578", "l": "EPH receptors autophosphorylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59311", "l": "D-galactono-1,5-lactone + H2O <=> D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66877", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849094", "l": "ARHGAP35 binds RASA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14211", "l": "diphosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76545", "l": "fumarate + N-acetyl-L-cysteine => N-acetyl-S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36783", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.108", "l": "\"2-(3-amino-3-carboxypropyl)histidine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204779", "l": "Interaction of Tie2 with Ang1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65716", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 = an aldehyde + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018661", "l": "orcinol 2-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865454", "l": "CBFB binds RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727607", "l": "MME:Zn2+ binds sacubitrilat (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36486", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20321", "l": "L-proline + NAD(+) = 1-pyrroline-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65196", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine = H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.26", "l": "\"beta-fructofuranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714483", "l": "RAC2 translocates to the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11082", "l": "phosphate + thymidine => dTMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67108", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58605", "l": "FAD + 2 H(+) + NADH + O2 => FADH2-C4alpha-hydroperoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43887", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) <=> 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73055", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) = estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019165", "l": "thiamine kinase activity", "d": ["Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799466", "l": "TP53I3 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41080", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31958", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004085", "l": "butyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416683", "l": "SEMA3E binds to PLXND1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24272", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374298", "l": "Opioid receptors bind opioid peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710254", "l": "GSDME oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27499", "l": "3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => 3'-O-methyltricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72322", "l": "n chloride(in) + urate(out) <=> n chloride(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52988", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine = [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030380", "l": "interleukin-17E receptor binding", "d": ["Binding to an interleukin-17E receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42174", "l": "(8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O => (11Z)-eicosenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70973", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-dopa + H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22817", "l": "alpha-D-xylose => alpha-D-xylulofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877192", "l": "RUNX1 binds FOXP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50164", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788611", "l": "HYKK phosphorylates 5HLYS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.n1", "l": "\"cytokinin riboside 5'-monophosphate phosphoribohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40627", "l": "H2O + trihexadecanoylglycerol = 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375138", "l": "CDO binds BOC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686930", "l": "RIPK3 is cleaved by CASP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29350", "l": "2 H(+)(in) + orotate(in) <=> 2 H(+)(out) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38856", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205321", "l": "Interaction of KIT and sSCF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10603", "l": "prostaglandin H2 <=> prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111913", "l": "Calmodulin binds CAMK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199014", "l": "CD96 binds PVR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73964", "l": "(2E,6E)-farnesyl diphosphate => aristolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59577", "l": "anserine + H2O => beta-alanine + N(pros)-methyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32617", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-oxogeraniol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39526", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51780", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76432", "l": "Na(+)(out) + NH4(+)(in) => Na(+)(in) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714483", "l": "RAC2 translocates to the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68471", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0050785", "l": "advanced glycation end-product receptor activity", "d": ["Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61270", "l": "2-oxohexanoate + H2O2 + NH4(+) => H2O + L-2-aminohexanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205649", "l": "p62 links damaged mitochondria to LC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75527", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 = benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23541", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.27", "l": "\"phosphatidylglycerophosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209303", "l": "LGS transports from the nucleus to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13301", "l": "a 1,2-diacyl-sn-glycerol + a sterol = a 1-acyl-sn-glycerol + a sterol ester", "d": [], "t": []}, {"i": "EC:2.3.1.73", "l": "\"diacylglycerol--sterol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12005", "l": "indoxyl + UDP-alpha-D-glucose => H(+) + indican + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69077", "l": "(R)-noradrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21878", "l": "(S)-usnate + 2 H(+) + NADH => (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10561", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O => 2,5-dioxopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36610", "l": "2-oxoglutarate + L-arginine + O2 <=> (2S,3S)-hydroxyarginine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730903", "l": "Oligomerization of TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20814", "l": "acetyl-CoA + oxaloacetate => (3S)-citryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61421", "l": "(S)-8-oxocitronellyl enol => cis-cis-nepetalactol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25220", "l": "acetyl-CoA + serotonin <=> CoA + H(+) + N-acetylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17481", "l": "2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64757", "l": "H2O + S-benzyl-L-cysteine => benzylthiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72697", "l": "Start codon recognition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20005", "l": "an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate", "d": [], "t": []}, {"i": "EC:3.2.1.139", "l": "\"alpha-glucuronidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111238", "l": "Formation of ADAR2  homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68625", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109857", "l": "MAP2K1 binds MAPK3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35055", "l": "3,6-dichlorocatechol + O2 = (2E,4E)-2,5-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60751", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67385", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607734", "l": "PKC-delta translocates to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21161", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate => ATP + citrate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868236", "l": "BAR domain proteins recruit dynamin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20995", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine <=> 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008658", "l": "penicillin binding", "d": ["Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74561", "l": "aldosterone hemiacetal => aldosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20631", "l": "L-seryl-[protein] + phosphate => H2O + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804383", "l": "PRMT5 methylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007882", "l": "IL1F10 is cleaved (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61828", "l": "stigmasterol + UDP-alpha-D-glucose = H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453183", "l": "p-Y348-SYK dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604360", "l": "Initial activation of proMMP2 by MMP14 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58342", "l": "chenodeoxycholate + D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62483", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41359", "l": "bacteriochlorophyll a + 3 NADP(+) <=> geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993802", "l": "HLCS biotinylates PC:Mn2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76436", "l": "(2S,9S)-annullatin H + 2 A => (2S,9S)-annullatin D + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928615", "l": "EFNBs bind SFKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120225", "l": "coenzyme A binding", "d": ["Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799350", "l": "Exocytosis of specific granule membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216045", "l": "Collagen type I binds integrin alpha11beta1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11043", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658483", "l": "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873917", "l": "Translocation of STAT1 dimer to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018726", "l": "9-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66630", "l": "(2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2 => (2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912790", "l": "CBL binds CRK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37654", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25003", "l": "H(+) + N,N-dihydroxy-L-phenylalanine <=> (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961895", "l": "CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65876", "l": "5alpha-androst-1-ene-3,17-dione + H2O = 1-hydroxy-5alpha-androstan-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140161", "l": "monocarboxylate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050181", "l": "phorbol-diester hydrolase activity", "d": ["Catalysis of the reaction: H2O + phorbol 12,13-dibutanoate = butanoate + H+ + phorbol 13-butanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71384", "l": "L-asparagine(in) + Na(+)(in) => L-asparagine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51964", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784861", "l": "HSPG binds LPL dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75222", "l": "H2O + L-fucono-1,5-lactone <=> H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70145", "l": "28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11569", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP => 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27553", "l": "di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate => (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446364", "l": "Migfilin interacts with VASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362485", "l": "GHBP binds GH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874083", "l": "p-Y397-PTK2 binds SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48746", "l": "(-)-deoxypodophyllotoxin + CO2 + H2O + succinate => (-)-yatein + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398185", "l": "LARG binds plexin B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186798", "l": "GAP binds to PDGF-beta receptors only (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74744", "l": "kaempferol + S-adenosyl-L-methionine => 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662622", "l": "MT1X binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69074", "l": "Formation of Processive Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008819", "l": "cobinamide kinase activity", "d": ["Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379867", "l": "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61857", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 => betaenone C + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42029", "l": "NAD(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734475", "l": "PPARA binds fibrates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004679", "l": "AMP-activated protein kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75476", "l": "D-mannose(out) + n Na(+)(out) => D-mannose(in) + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30013", "l": "ADP + beta-D-galactose(in) + H(+) + phosphate => ATP + beta-D-galactose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73450", "l": "acetyl-CoA(in) + AMP(out) <=> acetyl-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71481", "l": "L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10) => H2O + neurotensin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68868", "l": "ATP + benzoate + H(+) + NADPH = AMP + benzaldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047543", "l": "2-hexadecenal reductase activity", "d": ["Catalysis of the reaction: NADP+ + palmitaldehyde = trans-hexadec-2-enal + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63166", "l": "taurine + tricosanoate => H2O + N-tricosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45272", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205289", "l": "Autophosphorylation of KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23505", "l": "adenosylcob(III)inamide + H2O => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033818", "l": "beta-ketoacyl-acyl-carrier-protein synthase III activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39309", "l": "(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22194", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23311", "l": "(E)-sinapoyl-CoA + D-glucarate <=> 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53011", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56970", "l": "dCDP + H(+) + phosphoenolpyruvate => dCTP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11490", "l": "an all-trans-retinyl ester + CoA => all-trans-retinol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32463", "l": "glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.156", "l": "\"glycine/sarcosine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73258", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine <=> (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.13", "l": "\"N(1)-acetylpolyamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204813", "l": "Interaction of Tie2 and Grb14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13933", "l": "all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35977", "l": "A + CO2 + H2O + succinate + verruculogen => 2-oxoglutarate + AH2 + fumitremorgin B + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18609", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.9", "l": "\"N-acetylornithine carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612516", "l": "EGR1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822985", "l": "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32045", "l": "2 ATP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42844", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH = 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": [], "t": []}, {"i": "EC:2.3.1.240", "l": "\"narbonolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16085", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187575", "l": "Ubiquitination of phospho-p27/p21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39776", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507875", "l": "Aquaporins passively transport urea into cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67934", "l": "ADP + desmosterol(out) + H(+) + phosphate => ATP + desmosterol(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55169", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20381", "l": "androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46183", "l": "2-methylbutanoate + ATP + CoA <=> 2-methylbutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72697", "l": "Start codon recognition (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51615", "l": "(R)-2-hydroxyglutarate + oxaloacetate <=> (R)-malate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939201", "l": "ESR dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10878", "l": "CO2 + phenol => 4-hydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046180", "l": "KSPG is secreted from the cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209566", "l": "TRAF6 is auto-ubiquitinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156699", "l": "Inactivation of Wee1 kinase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57660", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43642", "l": "3-oxotetradecanoyl-[ACP] + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11906", "l": "2,4-dihydroxypteridine + NH4(+) => 2-amino-4-hydroxypteridine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51538", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP => L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0032037", "l": "myosin I heavy chain binding", "d": ["Binding to a heavy chain of a myosin I complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57551", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] <=> [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705584", "l": "HMGCR dimer binds statins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58439", "l": "4-methylpentan-1-ol + NADP(+) <=> 4-methylpentanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654623", "l": "Activated FGFR3 binds FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17712", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate <=> 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10556", "l": "D-glyceraldehyde 3-phosphate + L-arginine = H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.66", "l": "\"N(2)-(2-carboxyethyl)arginine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60356", "l": "H2O + N-octanoylanthranilate = anthranilate + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59669", "l": "D-cellohexaose + O2 => D-cellohexaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55301", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051981", "l": "copper chelate transmembrane transporter activity", "d": ["Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65112", "l": "2-oxoglutarate + aculene D + O2 = aculene C + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60563", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848596", "l": "PTK6 binds PXN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73740", "l": "dopamine(in) + 2 H(+)(out) => dopamine(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33225", "l": "CO2 + NADH + propanoyl-CoA => 2-oxobutanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58619", "l": "N-octanoyl-(2S)-hydroxyglycine <=> glyoxylate + octanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51238", "l": "GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate => GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052916", "l": "23S rRNA (guanine(1835)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22838", "l": "a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] => a fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46483", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73908", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP => ADP + aeruginascin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047840", "l": "dCTP diphosphatase activity", "d": ["Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62615", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047682", "l": "aryl-alcohol oxidase activity", "d": ["Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002460", "l": "P4HB binds Collagen chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008688", "l": "3-(3-hydroxyphenyl)propionate hydroxylase activity", "d": ["Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705466", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917700", "l": "MVB Vesicle Formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68955", "l": "isoscopoletin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785711", "l": "Telomere shortening during replicative exhaustion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12693", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}, {"i": "EC:2.5.1.52", "l": "\"L-mimosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29407", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53262", "l": "1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14403", "l": "chlordecone + H(+) + NADPH => chlordecone alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25749", "l": "2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112437", "l": "Formation of NELF complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.5.-", "l": "\"Triphosphoric monoester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709406", "l": "CO binds to Cytochrome c oxidase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14324", "l": "morphine + NADP(+) <=> H(+) + morphinone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30958", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone <=> 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102179", "l": "24-ethylidenelophenol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ = 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24465", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005043", "l": "netrin receptor activity involved in chemorepulsion", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182988", "l": "Sprouty lures CBL away from EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140842", "l": "n fibrin monomers -> fibrin multimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158313", "l": "factor XII -> factor XIIa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097351", "l": "toxin sequestering activity", "d": ["Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50517", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33379", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O = (4R)-hydroxyeicosasphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73338", "l": "ATP + beta-alanine + tryptamine <=> AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30307", "l": "7-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050125", "l": "N-benzyloxycarbonylglycine hydrolase activity", "d": ["Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O + H+ = benzyl alcohol + CO2 + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72646", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64947", "l": "dCTP + 2 H2O <=> dCMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31106", "l": "7,8-dihydrofolate + NADP(+) <=> folate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74625", "l": "AMP(out) + UMP(in) => AMP(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39051", "l": "ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23701", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O => (6R)-10-formyltetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20611", "l": "glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-D-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11771", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate <=> 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18795", "l": "D-ribose 5-phosphate => alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69522", "l": "H(+) + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236970", "l": "Proteasomal clevage of exogenous antigen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691004", "l": "XPC binds RAD23 and CETN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051075", "l": "S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity", "d": ["Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34633", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202394", "l": "Translocation of CARMA1 to Plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70478", "l": "2 S-adenosyl-L-methionine + sphing-4-enine <=> 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617815", "l": "BBSome binds RAB3IP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033703", "l": "3beta-hydroxy-5beta-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75008", "l": "H(+)(out) + VO(2+)(out) => H(+)(in) + VO(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42004", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37984", "l": "gamma-tocopherol => 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54884", "l": "L-arginyl-[protein] + NADP(+) = H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.74", "l": "\"fragilysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22669", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + lipid A disaccharide (E. coli) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66624", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30687", "l": "(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56390", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51577", "l": "phloretin + UDP-alpha-D-glucose => H(+) + phlorizin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24761", "l": "H(+) + L-dopa + NADH => 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65079", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990609", "l": "glutamate-cysteine ligase regulator activity", "d": ["Binds to and modulates the activity of glutamate-cysteine ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60732", "l": "H2O + NADP(+) + perillyl aldehyde = 2 H(+) + NADPH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866304", "l": "pre-VLDL binds lipids to form VLDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44010", "l": "a 2-methyl fatty acid + 2 H(+) + NADH => a 2-methyl-branched fatty aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661474", "l": "Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37094", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16052", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47883", "l": "dioctanoylglycerol + H2O <=> H(+) + octanoate + octanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73139", "l": "lithocholate(out) = lithocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70412", "l": "4-hydroxyphenylacetyl-CoA + H2O => 4-hydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664879", "l": "ATM:PEX5 binds ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59804", "l": "L-phenylalanine = D-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29466", "l": "K(+)(in) <=> K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604553", "l": "HEY2 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32175", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67482", "l": "CO2 + H2O + kainate + succinate => 2-oxoglutarate + O2 + prekainate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190519", "l": "Internalization of gap junction plaques (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21583", "l": "(2S)-2-acetolactate + H(+) <=> (R)-acetoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0061605", "l": "molybdopterin-synthase adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72146", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49792", "l": "eicosanoyl-CoA + glycine = CoA + H(+) + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222237", "l": "SMYD2 methylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014294", "l": "RAC2 binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29493", "l": "cis-muurola-4(14),5-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22357", "l": "diphosphate + oxaloacetate => CO2 + phosphate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951727", "l": "cAMP binds PKA tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10850", "l": "ADP + an [alpha-factor](out) + H(+) + phosphate => an [alpha-factor](in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35912", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57135", "l": "L-ascorbate + O2 + tyramine <=> (R)-octopamine + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74365", "l": "coproporphyrin III(in) => coproporphyrin III(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11820", "l": "diphthamide-[translation elongation factor 2] + NAD(+) = H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.36", "l": "\"NAD(+)--diphthamide ADP-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.-.-", "l": "\"Catalysing the translocation of inorganic cations\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15193", "l": "dGTP + H2O = 2'-deoxyguanosine + H(+) + triphosphate", "d": [], "t": []}, {"i": "EC:3.1.5.1", "l": "\"dGTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19814", "l": "a 2-oxocarboxylate + L-asparagine => 2-oxosuccinamate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018695", "l": "4-cresol dehydrogenase (hydroxylating) activity", "d": ["Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162657", "l": "Inactivation of Myt1 kinase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043805", "l": "indolepyruvate ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53651", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19419", "l": "[phosphate](n+1) + a dolichyl phosphate => [phosphate](n) + a dolichyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27853", "l": "glycine + phenylacetyl-CoA <=> CoA + H(+) + phenylacetylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49604", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) = 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66928", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106418", "l": "UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity", "d": ["Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497866", "l": "Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17813", "l": "D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.58", "l": "\"tagaturonate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877153", "l": "STARD7 binds PC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36450", "l": "ATP + glycyl-L-proline(out) + H2O <=> ADP + glycyl-L-proline(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730840", "l": "Activation of RAC1 by VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12963", "l": "acetoacetyl-CoA + butanoate => acetoacetate + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633460", "l": "MDM2 binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19218", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane => 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50448", "l": "AH2 + prostaglandin G3 = A + H2O + prostaglandin H3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62847", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24063", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63053", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801355", "l": "TP53 binds the NLRC4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20200", "l": "[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008054", "l": "IL1F10 binds IL1RAPL1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62753", "l": "H2O + pravastatin lactone => (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70925", "l": "(R)-noradrenaline(in) + chloride(in) + Na(+)(in) => (R)-noradrenaline(out) + chloride(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40104", "l": "H2O + propanoyl-CoA => CoA + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22562", "l": "2'-hydroxyformononetin + 2 H(+) + NADPH => (3R)-vestitone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61441", "l": "acetyl-CoA + S-(2-succino)-L-cysteine => CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26513", "l": "H2O + L-prolinamide <=> L-proline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507869", "l": "Aquaporins passively transport glycerol into cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45518", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43710", "l": "diphosphate + hexadecanoyl-AMP => ATP + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74258", "l": "XDH oxidizes xanthine to form urate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731931", "l": "EDNRA binds selective ERAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58683", "l": "A + FADH2 <=> AH2 + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39893", "l": "dTDP + H(+) + vancomycin => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22972", "l": "butanal + CoA + NADP(+) = butanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708866", "l": "pro-F2R binds vorapaxar (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227881", "l": "Phosphorylation and release of IRF3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033793", "l": "aureusidin synthase activity", "d": ["Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001057", "l": "RNA polymerase IV activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34020", "l": "a 1-acylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55048", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O = (3E,5Z)-dodecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656254", "l": "Defective OGG1 mutants show decreased binding to 8-oxoguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69579", "l": "2-oxoadipate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] <=> CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050010", "l": "isovitexin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: isovitexin + UDP-D-glucose = H+ + isovitexin 2''-O-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209358", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32349", "l": "3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + tricetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876484", "l": "NPC2 transfers CHOL to NPC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56114", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-nonaprenylphenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710254", "l": "GSDME oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176298", "l": "Activation of claspin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50229", "l": "FADH2 + O2 + resorcinol => benzene-1,2,4-triol + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60724", "l": "dodecanal + H2O + NADP(+) = dodecanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-443831", "l": "14-3-3-zeta binds Raf1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18607", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+) => 1-amino-1-deoxy-scyllo-inositol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12615", "l": "glutathione disulfide + 2 L-cysteine => 2 glutathione + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708866", "l": "pro-F2R binds vorapaxar (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28068", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102458", "l": "cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose = cyanin betaine + vanillate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784959", "l": "BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912790", "l": "CBL binds CRK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65144", "l": "2-oxoglutarate + berkeleyone A + O2 = CO2 + H2O + preaustinoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684140", "l": "ATM phosphorylates RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38026", "l": "gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13985", "l": "ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine", "d": [], "t": []}, {"i": "EC:2.7.1.39", "l": "\"homoserine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38600", "l": "NADP(+) + nicotinate => nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26169", "l": "3-fumarylpyruvate + H2O => fumarate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56220", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196857", "l": "PANK2 phosphorylates PanK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72621", "l": "Ribosomal scanning  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39252", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH => (11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033942", "l": "4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity", "d": ["Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829183", "l": "F1 binds to F2 forming the F subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42840", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH = 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.237", "l": "\"neocarzinostatin naphthoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49487", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34303", "l": "L-lysine = L-pipecolate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.28", "l": "\"L-lysine cyclodeaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047386", "l": "fructose-2,6-bisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29326", "l": "fumarate(in) + succinate(out) <=> fumarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74643", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) = CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610735", "l": "NUMB binds ITCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111966", "l": "GRK2 binds CALM1:4Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75850", "l": "Addition of the third nucleotide on the nascent transcript (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660706", "l": "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75141", "l": "asukamycin + H2O + NAD(+) => 4-hydroxyprotoasukamycin + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018824", "l": "(hydroxyamino)benzene mutase activity", "d": ["Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70632", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034007", "l": "S-linalool synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (S)-linalool + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029473", "l": "Branching and elongation of mother and daughter filaments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756414", "l": "SNAI1 binds the CDH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938887", "l": "PML binds RUNX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29054", "l": "2 H(+)(in) + H2 + menaquinone-8 <=> 2 H(+)(out) + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15276", "l": "2-oxoglutarate + L-dopa <=> 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27332", "l": "H(+) + NADH + O2 + urate <=> 5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59511", "l": "fumarate + L-cysteinyl-[protein] <=> S-(2-succinyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0008251", "l": "tRNA-specific adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27994", "l": "H2O + xanthosine = D-ribose + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27292", "l": "AH2 + CO2 => A + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938108", "l": "SERPINB13 binds cathepsin L (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53021", "l": "a plastoquinone + an L-alpha-amino acid + H2O => a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015362", "l": "high-affinity sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}, {"i": "REACT:R-HSA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090588", "l": "protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649735", "l": "Intrinsic nucleotide exchange on RAS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23025", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate => [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983152", "l": "Transfer of ubiquitin from E1 to E2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174070", "l": "Association of Cdh1 with the APC/C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50449", "l": "AH2 + prostaglandin G3 => A + H2O + prostaglandin H3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052741", "l": "(R)-limonene 6-monooxygenase activity", "d": ["Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56897", "l": "a carboxylate + ATP + H(+) => an acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840488", "l": "PSAP(195-273) forms a dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018758", "l": "RHOH binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199456", "l": "PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627089", "l": "CASP9 is phosphorylated at T412 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60764", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone = cinerin II + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63755", "l": "kermesate + UDP-alpha-D-glucose <=> carminate + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018624", "l": "toluene dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9671145", "l": "DKC1 binds SHQ1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66066", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754518", "l": "SARS-CoV-2 3a tetramer binds to CAV1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38154", "l": "carbonyl sulfide + H2O <=> CO2 + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27329", "l": "H(+) + NADH + O2 + urate = 5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.113", "l": "\"FAD-dependent urate hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483089", "l": "PE is converted to PS by PTDSS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909732", "l": "Phosphorylation of STAT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657836", "l": "NR1H2,3 binds the ANGPTL3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0050463", "l": "nitrate reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+."], "t": []}, {"i": "EC:1.7.1.2", "l": "\"nitrate reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088130", "l": "PLK1 binds FOXM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696958", "l": "USP44 deubiquitinates CDC20 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16115", "l": "2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH => 2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830423", "l": "GATA3 binds the RET gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72103", "l": "Formation of pre-mRNPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29814", "l": "ATP + H2O + thiamine(out) <=> ADP + H(+) + phosphate + thiamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70758", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15086", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400204", "l": "PPARA binds RXRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682769", "l": "LGI2 binds ADAM22,23 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55765", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O => 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19807", "l": "a purine nucleobase + alpha-D-ribose 1-phosphate => a purine D-ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433418", "l": "Phosphorylation of JAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114254", "l": "CYCS binds to APAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54520", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cycloaraneosene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.191", "l": "\"cycloaraneosene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30438", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15028", "l": "S-adenosyl-L-methionine + xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44819", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670673", "l": "FIX is secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0010436", "l": "carotenoid dioxygenase activity", "d": ["Catalysis of the oxidative cleavage of carotenoids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140693", "l": "molecular condensate scaffold activity", "d": ["Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004420", "l": "hydroxymethylglutaryl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759882", "l": "Expression of FOXF1 in lateral plate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36315", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59354", "l": "H2O2 + lactobiono-1,5-lactone => beta-lactose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985201", "l": "ABCE1 binds RNASEL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19170", "l": "L-serine => NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21824", "l": "2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate", "d": [], "t": []}, {"i": "EC:2.6.1.1", "l": "\"aspartate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23221", "l": "4-chlorobenzoate + ATP + CoA => 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209536", "l": "IkB is ubiquitinated and degraded (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678854", "l": "S1PR1 binds S1PR1 agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59708", "l": "D-maltotriono-1,5-lactone + H2O = D-maltotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229283", "l": "LCNs bind lipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19797", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265456", "l": "NPC1L1 binds ezetimibe (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57046", "l": "3-oxoisoapionate + H(+) + NADH => D-apionate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47333", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683113", "l": "Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25839", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015394", "l": "uridine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13838", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => 4,5-dihydroxyphthalate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70915", "l": "guanosine(in) + H(+)(in) = guanosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71651", "l": "a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28872", "l": "D-fructuronate(in) + H(+)(in) => D-fructuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072591", "l": "citrate-L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106223", "l": "germacrene A hydroxylase activity", "d": ["Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693783", "l": "NAALADases hydrolyse NAAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29745", "l": "2-phenylethylamine(out) => 2-phenylethylamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210289", "l": "Recruitment of SYK to p-DAP12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190263", "l": "FGFR3b binds to FGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47364", "l": "a dodecanoate ester + H2O = an aliphatic alcohol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14625", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) = [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": [], "t": []}, {"i": "EC:2.4.1.2", "l": "\"dextrin dextranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46370", "l": "a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74304", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74654", "l": "CTP + N-acetyl-D-glucosamine <=> CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047806", "l": "cytochrome-c3 hydrogenase activity", "d": ["Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27906", "l": "butanoyl-CoA + NADP(+) = (2E)-butenoyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.86", "l": "\"crotonyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1297444", "l": "Binding of cAMP to HCN channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60261", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64377", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682388", "l": "Autophagosome maturation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22013", "l": "precorrin-4 + S-adenosyl-L-methionine => precorrin-5 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70720", "l": "L-alanine(in) => L-alanine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52930", "l": "2 GMP + 2 H(+) => 3',3'-c-di-GMP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25279", "l": "AMP + H(+) => 3',5'-cyclic AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158399", "l": "kallikrein binds SERPING1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003850", "l": "2-deoxyglucose-6-phosphatase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15635", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+) => 3,4-dihydroxyphenylacetate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20140", "l": "10-deacetylbaccatin III + acetyl-CoA <=> baccatin III + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693347", "l": "CRYM reduces P2C to PPCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787594", "l": "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76704", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088130", "l": "PLK1 binds FOXM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189069", "l": "sucrose + H2O => glucose + fructose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139905", "l": "Translocation of activated BAD protein to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222491", "l": "Lactoferrin scavenges iron ions (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047765", "l": "caldesmon-phosphatase activity", "d": ["Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50528", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44268", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14427", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209944", "l": "25(OH)D binds GC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30791", "l": "dGTP + pyruvate = dGDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35987", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109702", "l": "PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1912357", "l": "ITCH ubiquitinates DTX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69068", "l": "RFC dissociates after sliding clamp formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106615", "l": "Removal of siRNA passenger strand (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32857", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726875", "l": "HCNs:cAMP bind SNIs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570528", "l": "SUMOylation of XPC with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44236", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008061", "l": "chitin binding", "d": ["Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750942", "l": "USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690702", "l": "LYN phosphorylates CD22 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015652", "l": "quaternary ammonium group:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802916", "l": "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31255", "l": "(2S)-2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47580", "l": "a ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31225", "l": "beta-D-glucose + cis-2-coumarate => cis-beta-D-glucosyl-2-hydroxycinnamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198756", "l": "ERK1/2 phosphorylates MSK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939335", "l": "RNF181 polyubiquinates BCL10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416683", "l": "SEMA3E binds to PLXND1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15163", "l": "H2O + homogentisate + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445705", "l": "Release Of ADP From Myosin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35733", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + CoA => sn-glycerol 3-phosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20916", "l": "L-cysteine + sulfite = hydrogen sulfide + L-cysteate", "d": [], "t": []}, {"i": "EC:4.4.1.10", "l": "\"cysteine lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709547", "l": "ESTG binds ESR2:chaperone complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22487", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> GMP + GTP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010298", "l": "dihydrocamalexic acid decarboxylase activity", "d": ["Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851077", "l": "JNK-dependent inhibition of TP53 ubiquitination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047095", "l": "2-hydroxycyclohexanone 2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60094", "l": "3-dehydro-4alpha-methylzymosterol + CO2 + NADH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17903", "l": "H(+) + S-adenosyl-L-homocysteine + xanthotoxin => S-adenosyl-L-methionine + xanthotoxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58190", "l": "dihydroisopentenyldehydrorhodopin + diphosphate => all-trans-lycopene + dimethylallyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.13", "l": "\"ABC-type autoinducer-2 transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39234", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031696", "l": "alpha-2C adrenergic receptor binding", "d": ["Binding to an alpha-2C adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38762", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63087", "l": "chloride + FADH2 + ilicicolin B + O2 <=> FAD + H(+) + 2 H2O + ilicicolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23992", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.63", "l": "\"1-alkylglycerophosphocholine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55389", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70302", "l": "H2O + L-dehydroascorbate <=> 2,3-dioxo-L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400267", "l": "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34844", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O => 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68686", "l": "adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate) => 3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10445", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54331", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH <=> hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77445", "l": "a ganglioside GT2 + H(+) + UDP => a ganglioside GT3 + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450975", "l": "isocitrate <=> citrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44866", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56919", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009817", "l": "Acitretin binds to RAR:RXR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29148", "l": "2 H(+)(in) + nitrate + ubiquinol-8 => 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45471", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate <=> (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53449", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800490", "l": "ATM phosphorylates PIDD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21188", "l": "ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)", "d": [], "t": []}, {"i": "EC:6.3.1.5", "l": "\"NAD(+) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674408", "l": "Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165195", "l": "GTP loading by Rheb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669024", "l": "CD70 binds CD27 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15395", "l": "meso-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944230", "l": "Association of procollagen type XVIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65227", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252133", "l": "ATP6AP1 binds V-ATPase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19438", "l": "nicotinate + UDP-alpha-D-glucose => N-(beta-D-glucosyl)nicotinate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46172", "l": "ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179417", "l": "Multiubiquitination of Nek2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45925", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042056", "l": "chemoattractant activity", "d": ["Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32586", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948027", "l": "RNASEs bind bacterial phospholipids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36060", "l": "A + dihydrourocanate => AH2 + urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68338", "l": "(R)-pantetheine sulfonate + phosphate => (R)-4'-phosphopantetheine sulfonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869694", "l": "oxPL binds CD14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912357", "l": "ITCH ubiquitinates DTX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10107", "l": "2-oxoglutarate + gibberellin A20 + O2 <=> CO2 + gibberellin A1 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25942", "l": "8-chloroquinolin-2(1H)-one + AH2 => 8-chloroquinoline + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31329", "l": "bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+) => 1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213466", "l": "RIPK3 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75375", "l": "inosine(in) = inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.29", "l": "\"aspartate/glutamate leucyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11401", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin => 4'-O-demethylsordarin + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651782", "l": "FEN1 bound to POLB cleaves displaced DNA strand (flap) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203977", "l": "SAR1 Activation And Membrane Binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446194", "l": "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16675", "l": "H(+) + phosphate + pyruvate => 3-phosphonopyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55473", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58526", "l": "(16S)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004995", "l": "tachykinin receptor activity", "d": ["Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28512", "l": "beta-D-glucose 6-phosphate + hydroquinone => arbutin 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51075", "l": "a phenol + an aryl sulfate <=> a phenol + an aryl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602473", "l": "Autocatalytic activation of MMP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69241", "l": "glucoraphanin + H2O => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.92", "l": "\"peptidoglycan beta-N-acetylmuramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71092", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.653642683099505", "identifiers": [{"i": "GO:0140110", "l": "transcription regulator activity", "d": ["A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947531", "l": "Molybdenum ion transfer onto molybdopterin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804253", "l": "MDM2 ubiquitinates JMY (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38307", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787820", "l": "IL34 dimer binds CSF1R (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20745", "l": "NADP(+) + prostaglandin D2 => 15-oxoprostaglandin D2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.88", "l": "\"non-reducing end beta-L-arabinopyranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19126", "l": "glyoxylate + L-serine => 3-hydroxypyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59845", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH => (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50032", "l": "H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.726079367374183", "identifiers": [{"i": "GO:0004722", "l": "protein serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11655", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose <=> alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27597", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018740", "l": "2'-hydroxybiphenyl-2-sulfinate desulfinase activity", "d": ["Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44144", "l": "acetyl-CoA + L-methionine = CoA + H(+) + N(alpha)-acetyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694581", "l": "RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008832", "l": "RUNX2 binds BAX gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66339", "l": "L-glutamate(out) <=> L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22552", "l": "3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.2", "l": "\"alcohol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004729", "l": "oxygen-dependent protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340124", "l": "CSN polymer binds CaPO4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73477", "l": "D-arginine(out) + L-ornithine(in) => D-arginine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49601", "l": "ATP + CoA + octanedioate => AMP + diphosphate + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59259", "l": "Fe(III)-enterobactin + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071208", "l": "histone pre-mRNA DCP binding", "d": ["Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607002", "l": "Activated protein C cleaves factor VIIIa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429815", "l": "Formation Of Bloc-1 Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814096", "l": "ARL1:GTP binds SCOC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.36", "l": "\"RING-type E3 ubiquitin transferase (cysteine targeting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67126", "l": "an alcohol + S-hydroxy-L-cysteinyl-[protein] => a hydroperoxide + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54975", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27674", "l": "ATP + dADP = ADP + dATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19908", "l": "NAD(+) + spermidine <=> dehydrospermidine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65013", "l": "decanoyl-AMP + holo-[ACP] => AMP + decanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106423", "l": "tubulin-tyrosine carboxypeptidase", "d": ["Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983707", "l": "SYK autophosphorylates at the activated BCR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55704", "l": "glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.59", "l": "\"sulfide-dependent adenosine diphosphate thiazole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70481", "l": "2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009488", "l": "IL34 binds CSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140704", "l": "3',2'-cyclic GMP-AMP binding", "d": ["Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36718", "l": "sphinganine + tetracosenoyl-CoA <=> an N-tetracosenoylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810076", "l": "DDO oxidizes D-Asp to OA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63104", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 = 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14965", "l": "an acyl phosphate + H2O = a carboxylate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.7", "l": "\"acylphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067659", "l": "Assembly of hexameric IL-6 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0016721", "l": "oxidoreductase activity, acting on superoxide radicals as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.15.-.-", "l": "\"Acting on superoxide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209179", "l": "ERF inhibits ETS2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71994", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> (-)-astellatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62429", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69933", "l": "inosine(in) + Na(+)(in) => inosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0008174", "l": "mRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71413", "l": "3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out) => 3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13392", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44457", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48655", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70406", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10798", "l": "albendazole S-oxide + H2O + NADP(+) => albendazole + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604712", "l": "Initial activation of proMMP7 by trypsin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22462", "l": "a 2,3-dehydroacyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40606", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187575", "l": "Ubiquitination of phospho-p27/p21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21322", "l": "AH2 + keto-L-sorbose => A + D-sorbitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398184", "l": "LARG activation by G alpha 12/13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809663", "l": "Formation of hair keratin fibres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14484", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48172", "l": "a ganglioside GM2 + H2O = a ganglioside GA2 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60008", "l": "a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607721", "l": "Activation of NIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481009", "l": "Exocytosis of platelet dense granule content (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038131", "l": "neuregulin receptor activity", "d": ["Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786583", "l": "PUS7 transforms uridine to pseudouridine in tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40701", "l": "1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963851", "l": "VD3 dissociates from GC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35704", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 => (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36040", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688797", "l": "ATXN3 family cleave Ub chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14238", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033936", "l": "polymannuronate hydrolase activity", "d": ["Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35334", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51729", "l": "dihydroxyacetone phosphate + H2O => dihydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43745", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine => AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170674", "l": "Dissociation of the Gi alpha:G olf complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46643", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77145", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10355", "l": "an N-acetylarylalkylamine + H2O <=> acetate + an aralkylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047856", "l": "dihydrocoumarin hydrolase activity", "d": ["Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47476", "l": "(3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15067", "l": "agmatine + benzoate => H2O + N(4)-benzoylagmatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909732", "l": "Phosphorylation of STAT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11867", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine <=> dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13624", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose <=> 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17791", "l": "(S)-reticuline + H(+) + S-adenosyl-L-homocysteine => (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76988", "l": "an N-acylsphing-4-enine(in) => an N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74581", "l": "N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964284", "l": "BTK in active Gq-BTK complex is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16938", "l": "1-O-alkyl-sn-glycerol + ATP => 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11586", "l": "D-ornithine => L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247960", "l": "Activation of p38 MAPK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72095", "l": "Internal Methylation of mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35424", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190141", "l": "ALAD binds to Pb2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399712", "l": "Activation of Ca permeable AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66866", "l": "diphosphate + quiannulatene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40075", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O = futalosine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.40", "l": "\"aminodeoxyfutalosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827992", "l": "Expression of TET2 in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788628", "l": "p-Y-STATs dissociate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74810", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15273", "l": "2-oxoglutarate + L-dopa = 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.49", "l": "\"dihydroxyphenylalanine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45647", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848392", "l": "IL18BP binds IL18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64445", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40689", "l": "1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22588", "l": "4-aminobutanal = 1-pyrroline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60197", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632182", "l": "PRMT1 methylates ESRs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19889", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}, {"i": "EC:2.7.7.9", "l": "\"UTP--glucose-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74646", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) <=> CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58286", "l": "H(+) + NADPH + thymine => 5,6-dihydrothymine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653514", "l": "USP17L2 deubiquitinates RCE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31885", "l": "delta-amyrin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68871", "l": "ATP + benzoate + H(+) + NADPH <=> AMP + benzaldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102762", "l": "eriodictyol 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + hesperetin(1-) + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840564", "l": "OMA1 hydrolyzes YME1L1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211224", "l": "Association of DFF40 with DFF45 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32796", "l": "ATP + H2O + L-cysteine(out) => ADP + H(+) + L-cysteine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005214", "l": "structural constituent of chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434650", "l": "MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22636", "l": "dCTP + H2O = dCMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13505", "l": "choline + O2 = betaine aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25504", "l": "(2E)-geranyl diphosphate = beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445084", "l": "Phosphorylation of L1 by SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701488", "l": "Active ALK phosphorylates JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673760", "l": "Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31183", "l": "acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10566", "l": "H(+) + methanol + oxaloacetate => H2O + oxaloacetate 4-methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684008", "l": "NBN binds KPNA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839067", "l": "Phosphorylation of BCR moiety of BCR-FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417843", "l": "P2Y13 binds ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45189", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19549", "l": "H2O + o-orsellinate depside = H(+) + 2 orsellinate", "d": [], "t": []}, {"i": "EC:3.1.1.40", "l": "\"orsellinate-depside hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211950", "l": "CYP24A1 24-hydroxylates CTL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638104", "l": "UGCG transfers glucose to ceramide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43720", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51647", "l": "cholesterol + H(+) + NADH + O2 <=> 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36551", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51551", "l": "(S)-tetrahydropapaverine + S-adenosyl-L-methionine <=> (S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029473", "l": "Branching and elongation of mother and daughter filaments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48106", "l": "H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70332", "l": "3-hydroxyphenylacetyl-CoA + H2O => 3-hydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017098", "l": "sulfonylurea receptor binding", "d": ["Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56846", "l": "nocamycin I + S-adenosyl-L-homocysteine => nocamycin E + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29242", "l": "H(+)(in) + uracil(in) <=> H(+)(out) + uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204549", "l": "Caveolin-1 binds Basigin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853898", "l": "VENTX binds the CSF1R (M-CSF-R) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703441", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23109", "l": "D-arabinono-1,4-lactone + H2O => D-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35590", "l": "FMN + H2O <=> phosphate + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432401", "l": "JET binds cytosolic TIM, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70346", "l": "chloride + L-tyrosine + NADP(+) <=> 3-chloro-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29288", "l": "2 H(+)(in) + L-aspartate(in) => 2 H(+)(out) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-901047", "l": "Binding of ERp57 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42012", "l": "cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49343", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52186", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170846", "l": "TGFBR2 recruits TGFBR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51157", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102851", "l": "1-18:2-2-16:0-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50051", "l": "ATP + cholate(in) + H2O <=> ADP + cholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30623", "l": "A + all-trans-neurosporene = AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19429", "l": "[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.11.15", "l": "\"[beta-adrenergic-receptor] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48246", "l": "a ganglioside GM1b + CMP + H(+) => a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60885", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481010", "l": "Surface deployment of platelet dense granule membrane components (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62575", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine <=> glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42719", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389083", "l": "Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5622129", "l": "FABP5 binds atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39459", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41655", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose <=> 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23232", "l": "4 Fe(III)-[cytochrome c] + hydrazine = 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": [], "t": []}, {"i": "EC:1.7.2.8", "l": "\"hydrazine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73801", "l": "dehydroechinulin + diphosphate => dimethylallyl diphosphate + isoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61114", "l": "(2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32540", "l": "(2E)-geranyl diphosphate => (+)-car-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32103", "l": "2 S-adenosyl-L-methionine + trans-resveratrol = 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.240", "l": "\"trans-resveratrol di-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75790", "l": "GTP(in) <=> GTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22565", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) => a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196753", "l": "2xPPCS ligates PPanK with Cys (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58421", "l": "NADP(+) + prenol => 3-methyl-2-butenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047902", "l": "formylaspartate deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54005", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683792", "l": "p-T68-CHEK2 autophosphorylates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48980", "l": "3,4-dichlorocatechol + O2 = (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62284", "l": "2 ATP + L-proline + L-tryptophan + NADPH = (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19573", "l": "[phosphate](n) + ATP = [phosphate](n+1) + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.1", "l": "\"ATP-polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39522", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102182", "l": "4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD = avenastenone + NADH + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102931", "l": "(Z,E)-alpha- farnesene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67625", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50005", "l": "H(+) + NADPH + O2 + tetracycline => 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16292", "l": "(1R,2S)-ephedrine + NAD(+) <=> (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32005", "l": "diphosphate + isopimara-8(14),15-diene => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33251", "l": "2 sucrose = 6-kestotriose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140772", "l": "CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + hexadecanoyl-CoA = CoA + H+ + N(6)-hexadecanoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:59768", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798374", "l": "DYRK2 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76764", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,4-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75624", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48071", "l": "a ganglioside GM2 (d18:1(4E)) + H2O <=> a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34299", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.94", "l": "\"2'-deamino-2'-hydroxyneamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37341", "l": "(R)-3-amino-2-methylpropanoate + CO2 + NH4(+) => 3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39379", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120170", "l": "intraciliary transport particle B binding", "d": ["Binding to an intraciliary transport particle B (IFT B) complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76220", "l": "GDP(in) => GDP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52218", "l": "[(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose => [(1''->2')-ADP-alpha-D-ribose](n) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43537", "l": "2 D-glyceraldehyde 3-phosphate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180710", "l": "Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65555", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + lactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660662", "l": "ASC binds Caspase-8 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70927", "l": "(R)-glycerate(in) + H(+)(in) = (R)-glycerate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17750", "l": "A + H2O + quinoline => AH2 + quinolin-2(1H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15069", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64662", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009936", "l": "RNASEL cleaves cellular ssRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10143", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31324", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690493", "l": "RHOB binds effectors on endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68067", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30190", "l": "(S)-dihydroorotate + a quinone <=> a quinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15843", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.27", "l": "\"D-galactarolactone cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16161", "l": "2 Fe(III)-[leghemoglobin] + NADH = 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204364", "l": "ROBO1 binds SLIT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757256", "l": "MCM3 binds MCM5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69142", "l": "Recruitment of Dna2 endonuclease (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66430", "l": "D-arabinose(in) + H(+)(in) => D-arabinose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990915", "l": "structural constituent of ascospore wall", "d": ["The action of a molecule that contributes to the structural integrity of an ascospore wall."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74777", "l": "7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977392", "l": "Expression of CEBPD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429955", "l": "CCR4-NOT complex deadenylates mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50538", "l": "H2O + prostaglandin A2 => prostaglandin E2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30138", "l": "dodecanoyl-CoA + H2O <=> CoA + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33059", "l": "(R)-dihydrolipoamide + NAD(+) = (R)-lipoamide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27939", "l": "(3R)-3-hydroxy-D-aspartate => glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619449", "l": "PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761027", "l": "ZEB2 binds SP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856525", "l": "ANGPTL8 binds ANGPTL3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29969", "l": "2'-deoxyuridine(out) + H(+)(out) => 2'-deoxyuridine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0098634", "l": "cell-matrix adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140696", "l": "factor V -> factor Va + factor V activation peptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.66", "l": "\"thermitase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295622", "l": "SPRY2 binds CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13552", "l": "beta-L-fucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24380", "l": "(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": [], "t": []}, {"i": "EC:2.1.2.9", "l": "\"methionyl-tRNA formyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19087", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21696", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54451", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O <=> a tRNA + an N-acyl-L-amino acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11115", "l": "H2O + isochorismate <=> (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18895", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12799", "l": "CO2 + H(+) + H2O + scopolamine + succinate => (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033741", "l": "adenylyl-sulfate reductase (glutathione) activity", "d": ["Catalysis of the reaction: AMP + glutathione disulfide + H+ + sulfite = 5'-adenylyl sulfate + 2 glutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77038", "l": "(2S)-heptan-2-amine + H2O + NAD(+) <=> H(+) + heptan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22898", "l": "a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63481", "l": "NADP(+) + prostaglandin F2alpha => 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24060", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76456", "l": "O-atom dealkylation of dextromethorphan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759496", "l": "CDH11 nascent mRNA is spliced into the canonical splicing isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43301", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer + UDP-N-acetyl-alpha-D-galactosamine => a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19588", "l": "lithocholate + NAD(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38619", "l": "nicotinate beta-D-ribonucleotide + phenol = H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": [], "t": []}, {"i": "EC:2.4.2.55", "l": "\"nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70692", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) => chloride(in) + glycine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57388", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.167", "l": "\"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030566", "l": "snRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168849", "l": "tBID binds to inactive BAX protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000511", "l": "H2A-H2B histone complex chaperone activity", "d": ["A histone chaperone that carries a H2A-H2B histone complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50895", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite <=> a menaquinol + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61272", "l": "H2O + L-2-aminopentanoate + O2 = 2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37988", "l": "delta-tocopherol => 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362437", "l": "C-terminal Hh fragments are bound by lectins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47479", "l": "(3E)-tetradecenoyl-CoA <=> (2E)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71482", "l": "H2O + neurotensin <=> L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68651", "l": "2 L-cysteine <=> H(+) + hydrogen sulfide + L-lanthionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710354", "l": "GSDME (1-270) binds cardiolipin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34232", "l": "5-nitrosalicylate + O2 => 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1606839", "l": "ARSC hydrolyzes steroid sulfates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64136", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine = (9Z)-octadecenoate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38481", "l": "H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine => N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047198", "l": "cysteine-S-conjugate N-acetyltransferase activity", "d": ["Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43751", "l": "ATP + CoA + hexacosanoate <=> AMP + diphosphate + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66594", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) => 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34170", "l": "2,6-dihydroxypseudooxynicotine + H2O <=> 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730856", "l": "Autophosphorylation of PAK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71680", "l": "H(+)(out) + L-lysyl-glycine(out) => H(+)(in) + L-lysyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13900", "l": "chorismate <=> prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156678", "l": "Activation of Cdc25C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22378", "l": "pseudouridine(38/39/40) in tRNA => uridine(38/39/40) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41488", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163310", "l": "TFAM binds to mitochondrial promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15327", "l": "a 1-acyl-sn-glycero-3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59635", "l": "D-xylobiose + O2 <=> D-xylobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050139", "l": "nicotinate-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34858", "l": "2 H2O + iminodiacetonitrile <=> N-(cyanomethyl)glycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40219", "l": "H2O + malonyl-CoA = CoA + H(+) + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31343", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.85", "l": "\"glucosyl-3-phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981606", "l": "Myoglobin binds oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72719", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-dihydrolipoyl]-5'-AMP = AMP + 2 H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45745", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) => 7,8-dihydropteroate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76084", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39141", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371422", "l": "ATP hydrolysis by HSP70 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52199", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17041", "l": "adenosine 5'-phosphosulfate + H2O = AMP + 2 H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.6.2.1", "l": "\"adenylylsulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68070", "l": "a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11433", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside => 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204798", "l": "Interaction of Tie2 and p85 of PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614271", "l": "Autocleavage of ADGRG6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665404", "l": "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809707", "l": "MTMR12 binds MTMR2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32296", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH => 2 diphosphate + NADP(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912363", "l": "PRDM9 binds recombination hotspot motifs in DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043817", "l": "phosphosulfolactate synthase activity", "d": ["Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41536", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.303", "l": "\"2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57428", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] = formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72166", "l": "chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) <=> chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102067", "l": "geranylgeranyl diphosphate reductase activity", "d": ["Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44978", "l": "CoA + O-propanoyl-(R)-carnitine => (R)-carnitine + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174367", "l": "GCL ligates L-Glu to L-Cys (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71922", "l": "3 Na(+)(out) + succinate(out) <=> 3 Na(+)(in) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41053", "l": "1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74624", "l": "AMP(in) + UMP(out) => AMP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24959", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167072", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58144", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18461", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.67", "l": "\"1-alkylglycerophosphocholine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51873", "l": "dimethylallyl diphosphate + umbelliferone => diphosphate + osthenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42563", "l": "uridine(27/28) in mitochondrial tRNA <=> pseudouridine(27/28) in mitochondrial tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878013", "l": "RUNX2 and SMAD1 complex binds the SMAD6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507871", "l": "Aquaporins passively transport glycerol out of cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033490", "l": "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709098", "l": "DHFR dimer reduces FOLA to DHF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16220", "l": "H2O + L-arabinono-1,4-lactone <=> H(+) + L-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047947", "l": "glutamine N-phenylacetyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36161", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70810", "l": "4-deoxy-4-sulfo-D-erythrose <=> 4-deoxy-4-sulfo-D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62198", "l": "acetone + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + propan-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42921", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA => H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60926", "l": "CO2 + formaldehyde + L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42927", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832040", "l": "M2-1 localizes to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62466", "l": "2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32072", "l": "geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20535", "l": "phosphate + pyridoxal => H2O + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047262", "l": "polygalacturonate 4-alpha-galacturonosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822437", "l": "DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34163", "l": "hydroquinone + O2 = (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.66", "l": "\"hydroquinone 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0032452", "l": "histone demethylase activity", "d": ["Catalysis of the removal of a methyl group from a histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46447", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 <=> (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28842", "l": "H(+)(out) + Zn(2+)(in) <=> H(+)(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055104", "l": "ligase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140616", "l": "iodotyrosine deiodinase activity", "d": ["Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350651", "l": "Caspase-mediated cleavage of MASK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49945", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31545", "l": "2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside) => all-trans-zeaxanthin + 2 UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050259", "l": "ribose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: H2O + NADP+ + ribofuranose = D-ribonate + 2 H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202724", "l": "P-selectin binds P-selectin ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29685", "l": "alpha-D-glucose 1-phosphate + alpha-maltopentaose => alpha-maltohexaose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042970", "l": "homoserine transmembrane transporter activity", "d": ["Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084912", "l": "Arresten binds integrin alpha1beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72945", "l": "2 Na(+)(in) + pyruvate(in) => 2 Na(+)(out) + pyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18743", "l": "10-deacetylbaccatin III + CoA => 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788622", "l": "p-Y-STATs dimerize (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22718", "l": "(24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46118", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620975", "l": "MLKL binds PIPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050109", "l": "morphine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635845", "l": "GLI proteins bind CDC73 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15845", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}, {"i": "EC:2.4.1.52", "l": "\"poly(glycerol-phosphate) alpha-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050090", "l": "mannuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981621", "l": "Neuroglobin:oxygen dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759158", "l": "SQSTM1 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047621", "l": "acylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856951", "l": "PP2A demethylation by PPME1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015485", "l": "cholesterol binding", "d": ["Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.1", "l": "\"acylaminoacyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396370", "l": "VTN binds collagens II, III and V (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051008", "l": "Hsp27 protein binding", "d": ["Binding to Hsp27 proteins, a lightweight heat shock protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47703", "l": "H(+) + ketocytochalasin + NADPH + O2 <=> H2O + iso-precytochalasin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201611", "l": "Caspase-mediated cleavage of Rock-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693593", "l": "D-loop extension by DNA polymerases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39216", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH => hexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65120", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione = L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65006", "l": "AMP + decanoyl-[ACP] + diphosphate => ATP + decanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198714", "l": "ERK5 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74663", "l": "acetylcholine(in) = acetylcholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71389", "l": "L-pipecolate(out) + Na(+)(out) => L-pipecolate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40919", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77224", "l": "gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine => 5'-deoxyadenosine + cob(III)alamin + geneticin + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26052", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12043", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508451", "l": "PTK2B is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64742", "l": "3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706364", "l": "Internalization of ubiquitinated FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030596", "l": "alpha-L-rhamnosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68847", "l": "(2Z,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22152", "l": "a ubiquinone + D-glucose = a ubiquinol + D-glucono-1,5-lactone", "d": [], "t": []}, {"i": "EC:1.1.5.2", "l": "\"quinoprotein glucose dehydrogenase (PQQ, quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203480", "l": "COLEC11 binds ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33544", "l": "ergosteryl palmitate + H2O => ergosterol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39947", "l": "a 1,3-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28399", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74736", "l": "S-adenosyl-L-methionine + syringetin => 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019001", "l": "guanyl nucleotide binding", "d": ["Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate."], "t": []}, {"i": "REACT:R-HSA-156909", "l": "eEF1A complexes with GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857686", "l": "FITM1, FITM2 bind TAGs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032791", "l": "lead ion binding", "d": ["Binding to lead (Pb) ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172172", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.183", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237102", "l": "Transamination of MOB to methionine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12467", "l": "myo-inositol + UDP-alpha-D-galactose <=> alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030627", "l": "pre-mRNA 5'-splice site binding", "d": ["Binding to a pre-mRNA 5' splice site sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68400", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-gurjunene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110518", "l": "Activated DTOR also phosphorylates D4EBP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.2", "l": "\"ABC-type nonpolar-amino-acid transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799097", "l": "ATM phosphorylates ZNF420 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50983", "l": "prostaglandin E1(out) <=> prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58730", "l": "H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine => adenosine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56045", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029473", "l": "Branching and elongation of mother and daughter filaments (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76848", "l": "(R)-sec-butylamine + H2O + NAD(+) => butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73416", "l": "(-)-cyclopenine => H(+) + methyl isocyanate + viridicatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43651", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72376", "l": "hydrogencarbonate(out) + iodide(in) => hydrogencarbonate(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832574", "l": "NS1 (1C) binds to NS2 (1B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10714", "l": "2-phenylacetamide + CO2 + H2O => L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49287", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP <=> CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31306", "l": "a reduced flavin + NAD(+) <=> an oxidized flavin + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75904", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] => ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351849", "l": "Caspase-mediated cleavage of Etk (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0000400", "l": "four-way junction DNA binding", "d": ["Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58850", "l": "(6E)-8-hydroxygeranial + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57119", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912627", "l": "CBL ubiquitinates PI3K (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102374", "l": "ursolic aldehyde 28-monooxygenase activity", "d": ["Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ = ursolic acid + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34456", "l": "all-trans-beta-carotene => 9-cis-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62694", "l": "2 H(+) + 2 H2O + 2 tellimagrandin II => 2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36138", "l": "(2E)-hexadecenal + H2O + NAD(+) <=> (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655836", "l": "Expression of Diphosphomevalonate Decarboxylase (MVD) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004095", "l": "carnitine O-palmitoyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29921", "l": "ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793666", "l": "MDM2 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41337", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75360", "l": "L-mimosine => 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28227", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047073", "l": "2,4'-dihydroxyacetophenone dioxygenase activity", "d": ["Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444511", "l": "Formation of MSH2:MSH3 Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33507", "l": "sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57776", "l": "2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008878", "l": "glucose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46393", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34507", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate = N,N-diacetyllegionaminate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.101", "l": "\"N,N'-diacetyllegionaminate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671772", "l": "p-T38-PPP1R14A binds MLCP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419166", "l": "GEFs activate RhoA,B,C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57936", "l": "H2O + isopyridoxal + NAD(+) = 5-pyridoxate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.102", "l": "\"isopyridoxal dehydrogenase (5-pyridoxate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9815510", "l": "MIB2 binds CYLD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13873", "l": "(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.18", "l": "\"abieta-7,13-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46551", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75271", "l": "S-adenosyl-L-methionine + serotonin = 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948612", "l": "miR-19b microRNA binds CNOT6L mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35318", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA <=> 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698923", "l": "Binding of the major capsid protein (MCP) to the pPR-AP:pAP complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354173", "l": "Activation of Rap1 by cytosolic GEFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33813", "l": "6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O => 3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156682", "l": "PLK1 phosphorylates NUDC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76653", "l": "3-methylbutanoate + 2 H(+) + NADPH => 3-methylbutanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336443", "l": "LIN7, CASK and APBA1 bind (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47746", "l": "demethylphylloquinol + NADP(+) => demethylphylloquinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36612", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 => (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033834", "l": "kaempferol 3-O-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27592", "l": "(R)-pantothenate + ADP + H(+) + phosphate => (R)-pantoate + ATP + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55625", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O => 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77207", "l": "3'-phosphoadenylyl sulfate + glycodeoxycholate = 3alpha-sulfoglycodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102890", "l": "naringenin chalcone 4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone = UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003875", "l": "ADP-ribosylarginine hydrolase activity", "d": ["Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047149", "l": "thetin-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27545", "l": "methanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51892", "l": "H2O + N-acetylcadaverine = acetate + cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41344", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48552", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40270", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17722", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20555", "l": "(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29332", "l": "fumarate(in) + 2 H(+)(in) => fumarate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214324", "l": "Collagen type VII dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33076", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine => 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76479", "l": "hexadecane-1,16-diol + O2 = H2O2 + hydroxyhexadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14758", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30566", "l": "dimethylallyl diphosphate + L-tryptophan <=> 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20716", "l": "H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:3.5.4.28", "l": "\"S-adenosylhomocysteine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40352", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65820", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56841", "l": "5-amino-2-hydroxybenzoate + O2 => (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139893", "l": "Granzyme-B activates BID by cleavage (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63259", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77128", "l": "1D-myo-inositol 1,2,3-trisphosphate + H2O => 1D-myo-inositol 2,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77387", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69838", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141126", "l": "short-chain fatty acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: a short-chain fatty acyl-CoA + H2O = a short fatty acid + CoA + H+. A short-chain fatty acid has an aliphatic tail of less than 6 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791154", "l": "Expression of GOSR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781905", "l": "ZRANB1 binds APC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41807", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102755", "l": "gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity", "d": ["Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77668", "l": "a globoside GalGb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a globoside GlcNAc-GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0016303", "l": "1-phosphatidylinositol-3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730903", "l": "Oligomerization of TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.249098858391747", "identifiers": [{"i": "GO:0004520", "l": "DNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043399", "l": "tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity", "d": ["Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37902", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 <=> 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34713", "l": "15-methylhexadecasphing-4-enine + a fatty acid => H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49128", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.326", "l": "\"N-acetyl-demethylphosphinothricin P-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73502", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31536", "l": "2-oxoglutarate + L-arginine + O2 => CO2 + guanidine + L-glutamate 5-semialdehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20183", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP => alpha-D-mannose derivative + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13587", "l": "ADP + butanoyl phosphate => ATP + butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972952", "l": "POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34524", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17714", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20913", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + taxa-4,11-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35824", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) => 7,8-dihydromethanopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30200", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420980", "l": "Activation of Ca permeable AMPA receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070840", "l": "dynein complex binding", "d": ["Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196753", "l": "2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n3", "l": "\"Dictyostelium lysozyme A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73469", "l": "beta-alanine + dopamine => beta-alanyl-dopamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43644", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA = 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373074", "l": "Receptor CCR9  binds CCL25 ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10127", "l": "H(+) + NADPH + O2 + phenylacetone <=> benzyl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68481", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) => CO2 + H2O + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36691", "l": "octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177942", "l": "EGFR binds EGF ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043898", "l": "2,3-dihydroxybiphenyl 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222237", "l": "SMYD2 methylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41382", "l": "4-methylphenol + H2O + NAD(+) => H(+) + NADH + O2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30925", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+) => (R)-glycerate + ADP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16770", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102937", "l": "16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63345", "l": "ATP + L-amino acyl-L-threonyl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.-", "l": "\"With NADH or NADPH as one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64468", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28727", "l": "Cu(2+)(in) + H(+)(in) = Cu(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138432", "l": "DVL2 is phosphorylated by PKC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964280", "l": "Active Gq binds BTK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20252", "l": "L-alanine <=> D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851988", "l": "BTN2A2 binds T cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254251", "l": "ERBB4s80 binds YAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19792", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) <=> 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30906", "l": "demethylspheroidene + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030734", "l": "polysaccharide O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45810", "l": "(2S,3R)-dihydroxy-5-oxohexanedioate + H2O => galactarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209910", "l": "Iodide is taken up by thyroid epithelial cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47967", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688137", "l": "RIP2 is K63 polyubiquitinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4837364", "l": "Secretion of SOD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71029", "l": "L-glutamine(out) + L-phenylalanine(in) => L-glutamine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49916", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183055", "l": "Binding of CBL to EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72065", "l": "glycoursodeoxycholate(in) + 2 Na(+)(in) => glycoursodeoxycholate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15001", "l": "keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.123", "l": "\"sorbose 5-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19038", "l": "an epoxide + H2O => an ethanediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035373", "l": "chondroitin sulfate proteoglycan binding", "d": ["Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75306", "l": "NAD(+) <=> 3'cADPR + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72869", "l": "A[3'-5']pG[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140741", "l": "WNT5A binds FZD and ROR receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609310", "l": "β-blockers bind ADRB1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43002", "l": "(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46271", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210805", "l": "Removal of miRNA passenger strand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36355", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.114", "l": "\"tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194796", "l": "botB LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114354", "l": "SMAC binds XIAP:Caspase-7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726509", "l": "NR3C2 binds fludrocortisone (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69344", "l": "(E)-but-1-en-1-SO-peroxol = (Z)-butanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68050", "l": "[protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine => [protein]-D-aspartate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204549", "l": "Caveolin-1 binds Basigin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865994", "l": "GAB1 binds PTPN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58077", "l": "1-(11Z-eicosenoyl)-glycerol + H2O => (11Z)-eicosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30780", "l": "D-gluconate + FAD + H(+) => 2-dehydro-D-gluconate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809309", "l": "MTMR6 binds MTMR9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25215", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29611", "l": "H2O + NADP(+) + nitrous oxide = H(+) + NADPH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72695", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985943", "l": "p-Y701-STAT1 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004368", "l": "glycerol-3-phosphate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43071", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36275", "l": "H(+) + NADPH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103033", "l": "beta-galactosidase activity (lactose isomerization)", "d": ["Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16363", "l": "3-hydroxy-3-methyl-2-oxobutanoate => 2-acetolactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62458", "l": "diphosphate + L-glutamyl-5'-AMP => ATP + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69053", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 => 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67836", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43516", "l": "2-carboxy-5-formylfuran + H2O = 2-carboxy-5-(dihydroxymethyl)furan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32474", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] <=> (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047940", "l": "glucuronokinase activity", "d": ["Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33708", "l": "ATP + L-threonine => ADP + H(+) + O-phospho-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102241", "l": "soyasaponin III rhamnosyltransferase activity", "d": ["Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III = H+ + UDP + soyasaponin I."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0034431", "l": "bis(5'-adenosyl)-hexaphosphatase activity", "d": ["Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate."], "t": []}, {"i": "RHEA:32047", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683355", "l": "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350391", "l": "RHO1:GTP binds to activated DAAM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.16.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73614", "l": "CTP(out) + dCDP(in) <=> CTP(in) + dCDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38130", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57779", "l": "2-chloro-6-nitrotoluene + NADH + O2 <=> 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53930", "l": "a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine => a tertiary amine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981728", "l": "Factor H binds to membrane-associated C3b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59778", "l": "D-arabinose + H2O2 => D-arabinitol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35426", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23895", "l": "3-nitropropanoate + NADP(+) <=> 3-nitroacrylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59430", "l": "3-hydroxypropanoate + 2 H(+) + NADPH => 3-hydroxypropanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0001847", "l": "opsonin receptor activity", "d": ["Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58728", "l": "adenosine in rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954199", "l": "CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39950", "l": "a 1,3-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33578", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31887", "l": "(S)-2,3-epoxysqualene = tirucalladienol", "d": [], "t": []}, {"i": "EC:5.4.99.56", "l": "\"tirucalladienol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30356", "l": "a quinol + methane + O2 => a quinone + H2O + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.2", "l": "\"dipeptidyl-peptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39886", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49606", "l": "2-glutathionyl-2-methylbut-3-enal + H(+) + NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71278", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) <=> 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31528", "l": "N(omega)-hydroxy-L-arginine => guanidine + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.205", "l": "\"galactogen 6beta-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759950", "l": "miR-200c-3p binds CDH11 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0106050", "l": "tRNA 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783670", "l": "CRLF1 binds CLCF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23919", "l": "H(+) + UDP-alpha-D-glucuronate <=> CO2 + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51136", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24233", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51432", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA = [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74385", "l": "2 (S)-lactate(out) + prostaglandin E2(in) => 2 (S)-lactate(in) + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55948", "l": "A + D-alanine + H2O = AH2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693356", "l": "CEMIP hydrolyses HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17427", "l": "acetyl-CoA + CO2 + NADPH => CoA + NADP(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73849", "l": "17alpha-sitoindoside IX + H(+) + UDP => 17alpha-hydroxywithaferin A + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047377", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity", "d": ["Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21270", "l": "berberine + H(+) + 2 NADPH => (R)-canadine + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042897", "l": "polymyxin transmembrane transporter activity", "d": ["Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649483", "l": "Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684169", "l": "G6B binds PTPN6,PTPN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71261", "l": "2 Na(+)(in) + phosphate(in) => 2 Na(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66212", "l": "asc-omegaC5-CoA + O2 = asc-omegaDeltaC5-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17582", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O => an L-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849878", "l": "PSD-95 binds NMDA receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163689", "l": "Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33459", "l": "H(+) + NADPH + zymosterone = NADP(+) + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35530", "l": "H(+) + N-ethylmaleimide + NADH <=> N-ethylsuccinimide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102081", "l": "homotaurine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) = 3-sulfopropanal + L-glutamate(1-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52159", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72163", "l": "chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047141", "l": "glutathione-cystine transhydrogenase activity", "d": ["Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46396", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.24", "l": "\"acyl-CoA 11-(E)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12896", "l": "prostaglandin H2 <=> prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381612", "l": "GLP1R binds GLP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169895", "l": "Crk's SH3 domain engages C3G (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59216", "l": "(indol-3-yl)acetate + H(+) = CO2 + skatole", "d": [], "t": []}, {"i": "EC:4.1.1.115", "l": "\"indoleacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63834", "l": "capsaicin + CoA + H(+) => (6E)-8-methylnon-6-enoyl-CoA + vanillylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77046", "l": "5-hydroxyoctan-4-amine + H2O + NAD(+) <=> 5-hydroxyoctan-4-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43101", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) => 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59361", "l": "carnosine + H2O => beta-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660536", "l": "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374173", "l": "AGT(34-41) binds to AGTR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51569", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399930", "l": "Activation of PAK by Rac1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211948", "l": "CYP3A4 can N-demethylate loperamide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034910", "l": "6-hydroxy-3-succinoylpyridine hydrolase activity", "d": ["Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928627", "l": "EPHB phosphorylates TIAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52775", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903981", "l": "enterobactin binding", "d": ["Binding to enterobactin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71404", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015341", "l": "zinc efflux active transmembrane transporter activity", "d": ["Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227863", "l": "Recruitment of IRF to activated TBK1/IKK epsilon (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66481", "l": "gypsogenin + UDP-alpha-D-glucose => gypsogenin 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55521", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate => 3 diphosphate + nerylneryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32284", "l": "3-hydroxyanthranilate + O2 => H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705082", "l": "SARS-CoV-2 nsp13 binds TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42870", "l": "caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine => norspermine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52556", "l": "3-dehydro-D-erythronate + ATP = 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853322", "l": "Plasma membrane FGFR1 fusions dimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72310", "l": "L-glutamate(in) + taurocholate(out) <=> L-glutamate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA => (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33045", "l": "(+)-6-exo-hydroxycamphor + H2O + NADP(+) => (1R,4R)-camphor + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030338", "l": "CMP-N-acetylneuraminate monooxygenase activity", "d": ["Catalysis of the reaction: CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654792", "l": "Expression of GRB10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70192", "l": "ATP + NAD(+) => 3'-NADP(+) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047897", "l": "formate-dihydrofolate ligase activity", "d": ["Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371591", "l": "Trimerization of cytosolic HSF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031683", "l": "G-protein beta/gamma-subunit complex binding", "d": ["Binding to a complex of G-protein beta/gamma subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805620", "l": "KAT6A and PML bind TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086079", "l": "gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016151", "l": "nickel cation binding", "d": ["Binding to a nickel (Ni) cation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912357", "l": "ITCH ubiquitinates DTX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30674", "l": "H2O + N,N'-diacetylchitobiose <=> 2 N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.4", "l": "\"cellulase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69503", "l": "L-arginyl-[protein] + NAD(+) <=> ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0031883", "l": "taste receptor binding", "d": ["Binding to a taste receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14723", "l": "H(+) + O-beta-D-xylosylzeatin + UDP => UDP-alpha-D-xylose + zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19997", "l": "H2O + phosphoenolpyruvate = phosphate + pyruvate", "d": [], "t": []}, {"i": "EC:3.1.3.60", "l": "\"phosphoenolpyruvate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33150", "l": "ATP + daunorubicin(in) + H2O <=> ADP + daunorubicin(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688137", "l": "RIP2 is K63 polyubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0031701", "l": "angiotensin receptor binding", "d": ["Binding to an angiotensin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32513", "l": "(3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53798", "l": "deoxycholate + ursodeoxycholoyl-CoA => deoxycholoyl-CoA + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428918", "l": "Dissociation of the TP:G13 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22335", "l": "(3R)-citramalate <=> 2-methylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809521", "l": "BPIF binds bacteria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25108", "l": "ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848414", "l": "Activated PTK6 binds CDKN1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53490", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) => 11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018499", "l": "cis-2,3-dihydrodiol DDT dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59458", "l": "H(+) + NADPH + tetradecanal => NADP(+) + tetradecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754964", "l": "ADA deamidates RBV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683888", "l": "LMCD1 binds GATA6, sequestering it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.127", "l": "\"jasmonoyl-L-amino acid hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381798", "l": "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39262", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA <=> (2E,13Z)-docosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65626", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine => hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12675", "l": "a nitrile + H2O => an aliphatic amide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9822539", "l": "VWF multimer binds to collagen type I (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14873", "l": "indole-3-ethanol + NAD(+) = H(+) + indole-3-acetaldehyde + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.190", "l": "\"indole-3-acetaldehyde reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16261", "l": "L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043884", "l": "CO-methylating acetyl-CoA synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047128", "l": "1,2-dehydroreticulinium reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-reticuline + NADP+ = 1,2-dehydroreticuline + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70754", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18433", "l": "cyclohexylamine + H2O + O2 = cyclohexanone + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.12", "l": "\"cyclohexylamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205289", "l": "Autophosphorylation of KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71365", "l": "17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in) => 17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352981", "l": "phosphoenolpyruvate + H2O <=> 2-phosphoglycerate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63224", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702638", "l": "tandutinib-resistant FLT3 mutants don't bind tandutinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16576", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018641", "l": "6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "d": ["Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102763", "l": "phytyl-P kinase activity", "d": ["Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19506", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose => (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004078", "l": "biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32970", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102621", "l": "emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity", "d": ["Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ = 14,15-epoxyemindole-SB + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018814", "l": "RHOT1 hydrolyzes GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18669", "l": "adenosine + H2O = adenine + D-ribose", "d": [], "t": []}, {"i": "EC:3.2.2.7", "l": "\"adenosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30365", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate => fumonisin B1 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.117", "l": "\"aflatoxin B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202703", "l": "CD47 binds SIRP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388830", "l": "PI3K binds ICOS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.-", "l": "\"Cis-trans isomerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140949", "l": "histone H3K9 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47347", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44317", "l": "1-dodecanoylglycerol + H2O => dodecanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28929", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+) => 3,4,5-trihydroxybenzoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693198", "l": "RHOD binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75135", "l": "NADP(+) + neopine = H(+) + NADPH + neopinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49635", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate <=> (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32008", "l": "9alpha-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.14", "l": "\"N-acyl-aliphatic-L-amino acid amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.2", "l": "\"dynein ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13048", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112429", "l": "Formation of FACT complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32144", "l": "L-arginine(in) => L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28912", "l": "H(+)(out) + L-lysine(out) => H(+)(in) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13821", "l": "2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.64", "l": "\"glutarate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25179", "l": "3-methylbutanoyl-CoA + CO2 + NADH => 4-methyl-2-oxopentanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66407", "l": "ATP + glutathione(in) + H2O + taurocholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299338", "l": "Activation of TRESK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57961", "l": "dimethyl sulfide + H(+) + NADH + O2 => dimethyl sulfoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66091", "l": "L-kynurenine + oxaloacetate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796053", "l": "PRKCI phosphorylates NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25214", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29103", "l": "5 H(+)(in) + menaquinone-8 + NADH = 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20307", "l": "4-hydroxybenzoate + 2 H(+) + NADH => 4-hydroxybenzaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372819", "l": "PCK2 phosphorylates OA to yield PEP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634886", "l": "NPAS4 binds RBFOX3 (NeuN) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17084", "l": "(E)-isoeugenol + S-adenosyl-L-methionine <=> (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106267", "l": "3,5 dichloro-THPH synthase activity", "d": ["Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O."], "t": []}, {"i": "RHEA:64360", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76451", "l": "(E)-4-coumaroyl alcohol + A = (E)-4-coumaraldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26313", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": [], "t": []}, {"i": "EC:4.1.2.56", "l": "\"2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318415", "l": "ATF2 acetylates histone H2B, H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160874", "l": "HYAL1 hydrolyses (HA)50 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41838", "l": "3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexanoyl-[ACP] + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013990", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15437", "l": "a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.50", "l": "\"long-chain-fatty-acyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622377", "l": "CEBPB mRNA is translated to yield CEBPB protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783492", "l": "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43829", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21528", "l": "[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.11", "l": "\"exopolyphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449087", "l": "CD4 binds Interleukin-16 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033877", "l": "succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836927", "l": "SUPV3L1 unwinds double-stranded mitochondiral RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454699", "l": "AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11432", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.153", "l": "\"vitexin 2''-O-rhamnoside 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805981", "l": "HMGB1 release from cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691131", "l": "CANDI binds CUL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47246", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+) => (2R)-3-phosphoglycerate + an NDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74285", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25835", "l": "1D-chiro-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37613", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76990", "l": "an N-acylsphing-4-enine(in) <=> an N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38718", "l": "ATP + choline(out) + H2O <=> ADP + choline(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58083", "l": "1-docosanoylglycerol + H2O <=> docosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061708", "l": "tRNA-5-taurinomethyluridine 2-sulfurtransferase", "d": ["Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928646", "l": "EPHAs bind EFNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21740", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": [], "t": []}, {"i": "EC:2.8.1.2", "l": "\"3-mercaptopyruvate sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139919", "l": "Translocation of BIM to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64469", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76293", "l": "Na(+)(in) + xanthine(in) => Na(+)(out) + xanthine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205289", "l": "Autophosphorylation of KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14970", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13256", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483174", "l": "PE is methylated to PC by PEMT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26434", "l": "indole + L-serine = H2O + L-tryptophan", "d": [], "t": []}, {"i": "EC:4.2.1.122", "l": "\"tryptophan synthase (indole-salvaging)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19230", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) => an aromatic carboxylate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187575", "l": "Ubiquitination of phospho-p27/p21 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610720", "l": "PKA phosphorylates GLI3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22162", "l": "a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA => 4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38251", "l": "hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11614", "l": "2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008921", "l": "lipopolysaccharide-1,6-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.24", "l": "\"(E3-independent) E2 ubiquitin-conjugating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949580", "l": "F1Fo ATP synthase dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357483", "l": "RAC1 binds PAK1-3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49795", "l": "eicosanoyl-CoA + glycine <=> CoA + H(+) + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004591", "l": "oxoglutarate dehydrogenase (succinyl-transferring) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047866", "l": "dimethylglycine oxidase activity", "d": ["Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = formaldehyde + H2O2 + sarcosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33098", "l": "chorismate + inosine + phosphoenolpyruvate <=> futalosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995334", "l": "COX15 transforms heme O to heme A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390835", "l": "DRD1,5 bind DA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32280", "l": "allantoate + 2 H(+) + 2 H2O => (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32465", "l": "2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine => glycine + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676264", "l": "Formation of the SET1B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75432", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30700", "l": "2-oxoglutarate + beta-alanine => 3-oxopropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43206", "l": "2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615015", "l": "FOXO6 binds PLXNA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31892", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446364", "l": "Migfilin interacts with VASP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60455", "l": "2-hydroxyethane-1-sulfonate <=> acetaldehyde + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53429", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] => a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55814", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44815", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51582", "l": "a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013110", "l": "RHOC binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964274", "l": "G alpha (12) binds BTK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424476", "l": "Activation of RAC1 by VAV2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68568", "l": "N(5)-hydroxy-L-ornithine = (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:4.8.1.1", "l": "\"L-piperazate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090560", "l": "2-(3-amino-3-carboxypropyl)histidine synthase activity", "d": ["Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139909", "l": "Translocation of BMF to mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29773", "l": "ADP + arsenate(out) + H(+) + phosphate => arsenate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64858", "l": "diphosphate + phomopsene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36046", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804100", "l": "HMGB1 binds LPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59060", "l": "(20S)-ginsenoside Rg3 + H2O = (20S)-ginsenoside Rh2 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71224", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) => chloride(in) + 2 Na(+)(in) + taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16385", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 = CO2 + H2O + hydroquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11418", "l": "1,6-bis-O-galloyl-beta-D-glucose + D-glucose => 2 1-O-galloyl-beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48148", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O = ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37200", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48358", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59209", "l": "ATP + H(+) + octadecanoate => diphosphate + octadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663232", "l": "FMNL1 binds RAC1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36256", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31058", "l": "estrone 3-sulfate + H2O <=> estrone + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21202", "l": "(S)-2-amino-6-oxohexanoate + L-glutamate => 2-oxoglutarate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450466", "l": "AUF1:mRNA complex is destroyed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16727", "l": "a phosphatidylglycerol + phosphate => a phosphatidylglycerol phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211960", "l": "CYP2U1 19-hydroxylates ARA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050377", "l": "UDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: UDP-D-glucose = H2O + UDP-4-dehydro-6-deoxy-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.11", "l": "\"ABC-type methionine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71164", "l": "homogentisate + O2 => maleylacetoacetate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47157", "l": "7alpha,25-dihydroxycholesterol + NAD(+) => 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30603", "l": "15-cis-phytoene + A = AH2 + all-trans-phytofluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.528207968973732", "identifiers": [{"i": "GO:0016628", "l": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29197", "l": "a menaquinol + orotate => (S)-dihydroorotate + a menaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74694", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086084", "l": "cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication", "d": ["Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58945", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH => 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001147", "l": "camalexin binding", "d": ["Binding to camalexin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76414", "l": "2',3'-cGAMP(out) + n H(+)(out) <=> 2',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754130", "l": "CDK4 inhibitors bind CDK4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111915", "l": "CAMK4 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003873", "l": "6-phosphofructo-2-kinase activity", "d": ["Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166792", "l": "Conversion of C2 into C2a and C2b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37292", "l": "H2O + L-alanyl-L-leucine => L-alanine + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17648", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38850", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36018", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36196", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.55", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56101", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) => [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60218", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12556", "l": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.31", "l": "\"6-phosphogluconolactonase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21601", "l": "anthranilate + benzoyl-CoA => CoA + N-benzoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71663", "l": "a menaquinone + 2 H(+)(out) + succinate = a menaquinol + fumarate + 2 H(+)(in)", "d": [], "t": []}, {"i": "EC:7.1.1.12", "l": "\"succinate dehydrogenase (electrogenic, proton-motive force generating)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47809", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54926", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP] => (7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71919", "l": "3 Na(+)(out) + succinate(out) = 3 Na(+)(in) + succinate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37608", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40263", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034921", "l": "cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201639", "l": "Caspase-mediated cleavage of GAS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52782", "l": "2-sulfenohercynine + NH4(+) + pyruvate => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26263", "l": "2 H(+) + isopimarate + NADPH => H2O + isopimara-7,15-dienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332236", "l": "CBL neddylates TGFBR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60141", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103045", "l": "methione N-acyltransferase activity", "d": ["Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n3", "l": "\"curcumin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612501", "l": "SGK phosphorylates CREB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA <=> 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193068", "l": "CYP17A1 17-hydroxylates PREG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696266", "l": "RND2 binds effectors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198314", "l": "DAG stimulates protein kinase C-delta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68142", "l": "(2R,5R)-hexanediol + 2 NADP(+) => 2,5-hexanedione + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869568", "l": "NPM1 binds TFAP2A homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632738", "l": "DDIT4 binds 14-3-3 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851988", "l": "BTN2A2 binds T cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29185", "l": "2 H(+) + menaquinone-8 + 2 superoxide => menaquinol-8 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57299", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015158", "l": "raffinose transmembrane transporter activity", "d": ["Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13562", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637795", "l": "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19975", "l": "H(+) + S-methyl-5'-thioadenosine + spermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785762", "l": "IL13RA1 binds TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689111", "l": "PARK2 autoubiquitinates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849085", "l": "ARHGAP35 binds RHOA:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0016420", "l": "malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49032", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.132", "l": "\"(-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21041", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977959", "l": "ERBB4 forms heterodimers with EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005340", "l": "Expression of SOCS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34354", "l": "(2E)-geranial + H2O + NAD(+) <=> geranate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25027", "l": "NH4(+) + S-methyl-5'-thioinosine => H(+) + H2O + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013159", "l": "CDC42 GEFs activate CDC42 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25736", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66252", "l": "ATP + CoA + IC-asc-C7 = AMP + diphosphate + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12600", "l": "acetyl-CoA + phosphinothricin <=> CoA + H(+) + N-acetylphosphinothricin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41180", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12713", "l": "a nucleoside 5'-phosphate + ATP = a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.6.4", "l": "\"nucleotide diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140761", "l": "sequestered tissue factor -> tissue factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40385", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31391", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) = all-trans-4,4'-diapolycopene + 4 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41266", "l": "NAD(+) + prostaglandin A1 <=> 15-oxo-prostaglandin A1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705726", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681616", "l": "AP2 binds chlorpromazine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73647", "l": "CTP(out) + IMP(in) = CTP(in) + IMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69784", "l": "(2-aminophenyl)succinate + succinyl-CoA => 2-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77364", "l": "2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine => 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193702", "l": "Part of the ICD migrates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.13", "l": "\"sucrose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371435", "l": "Constitutive phosphorylation by GSK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44192", "l": "2-methylhexadecanoate + ATP + CoA = 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129375", "l": "Elastin cross-linking by lysyl oxidase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68210", "l": "1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71783", "l": "MDH2 reduces OA to MAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183052", "l": "CBL binds to GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391942", "l": "IP receptor can bind prostacyclin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047227", "l": "indolylacetyl-myo-inositol galactosyltransferase activity", "d": ["Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46161", "l": "a quinone + H(+) + NADH => a quinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36353", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858506", "l": "Defective GYS2 does not transfer glucose to growing glycogen chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18562", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797810", "l": "PTPRD binds IL1RAPL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71600", "l": "2-oxoglutarate(out) + maleate(in) => 2-oxoglutarate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56456", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U", "d": [], "t": []}, {"i": "EC:5.5.1.33", "l": "\"12-epi-fischerindole U synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3318415", "l": "ATF2 acetylates histone H2B, H4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42470", "l": "2-oxopent-4-enoate + salicylate => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61202", "l": "CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620723", "l": "VGF gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019180", "l": "dTDP-4-amino-4,6-dideoxygalactose transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004452", "l": "isopentenyl-diphosphate delta-isomerase activity", "d": ["Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000824", "l": "inositol tetrakisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64315", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin <=> dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167130", "l": "Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10745", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => 3,4-dihydroxybenzoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72396", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) => 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40224", "l": "4,8-dimethylnonanoyl-CoA + H2O => 4,8-dimethylnonanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848774", "l": "PTK6 binds DOK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28034", "l": "[thioredoxin]-disulfide + dADP + H2O = [thioredoxin]-dithiol + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809707", "l": "MTMR12 binds MTMR2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963872", "l": "VD3 translocates from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030987", "l": "high molecular weight kininogen receptor binding", "d": ["Binding to a high molecular weight kininogen receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37998", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70996", "l": "L-cystine(out) + L-glutamate(in) => L-cystine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981832", "l": "NMUR2 binds neuromedin-S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48943", "l": "an L-aminoacyl-L-amino acid + H2O <=> 2 an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706399", "l": "RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956659", "l": "ABL1 phosphorylates YAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031764", "l": "type 1 galanin receptor binding", "d": ["Binding to a type 1 galanin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74986", "l": "Elongation of pre-rRNA transcript (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3782655", "l": "HDAC10 deacetylates histone (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671737", "l": "p-T774-PKN1 binds CDC25C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072548", "l": "dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052717", "l": "tRNA-specific adenosine-34 deaminase activity", "d": ["Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30055", "l": "L-allo-threonine + NADP(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49559", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] <=> H(+) + L-cysteinyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74723", "l": "Endosome acidification (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30477", "l": "D-glucuronate + H(+) + oroxylin A => H2O + oroxylin A 7-O-beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008345", "l": "RUNX2-P1 binds RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72012", "l": "glutathione(in) + urate(out) => glutathione(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601843", "l": "Defective CYP17A1 does not 17-hydroxylate PREG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062189", "l": "anandamide 14,15 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:53148", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72722", "l": "eIF2 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9623384", "l": "α1-agonists bind ADRA1A,B,D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202731", "l": "JAM3 dimerises (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66794", "l": "(3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-D-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614591", "l": "Excess cysteine yields lanthionine and H2S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912416", "l": "NOTCH1 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54638", "l": "diphosphate + labda-7,13(16),14-triene => (13E)-labda-7,13-dien-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27668", "l": "CO2 + propanoyl-CoA => (R)-methylmalonyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357472", "l": "PAK1-3 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835266", "l": "Expression of PAX3 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668404", "l": "TNFA binds TNFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218805", "l": "PKC autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754974", "l": "ADK phosphorylates RBV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9612509", "l": "SGK phosphorylates SRF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68302", "l": "CoA + O-tetradecanoyl-L-seryl-[protein] => L-seryl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832123", "l": "HNF1B binds the IRX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032781", "l": "WWTR1 (TAZ) binds TEAD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183067", "l": "Localization of CBL:GRB2 to the membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40121", "l": "CoA + H(+) + tetradecanoate => H2O + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38770", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50731", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime <=> 4-hydroxyphenylacetonitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18705", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52698", "l": "a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39322", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17731", "l": "a cholesterol ester + CoA => an acyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391933", "l": "EP3 receptor can bind PGE2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015550", "l": "galacturonate transmembrane transporter activity", "d": ["Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23625", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) => a uridine in tRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018758", "l": "RHOH binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110219", "l": "Cleavage of thymine by TDG glycosylase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51741", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43984", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72298", "l": "malate(out) + 3 Na(+)(out) <=> malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67876", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine = 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362386", "l": "Glycosylation of Hh (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25927", "l": "A + H2O + quinolin-8-ol <=> 8-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65870", "l": "1,17beta-dihydroxyandrostan-3-one => Delta(1)-dihydrotestosterone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685318", "l": "BCDX2 complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110215", "l": "Cleavage of uracil by UNG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31120", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA => (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24262", "l": "2-oxopent-4-enoate + CO2 => (3E)-2-oxohex-3-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203611", "l": "N-myristoylation of eNOS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936989", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48591", "l": "2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627369", "l": "SEPT4 binds XIAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62077", "l": "D-galactose 6-phosphate + NAD(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50713", "l": "chloride + FADH2 + O2 + tetracycline => 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050146", "l": "nucleoside phosphotransferase activity", "d": ["Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56409", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10217", "l": "[DNA-directed RNA polymerase] + ATP => ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32064", "l": "8-oxo-dGDP + H2O => 8-oxo-dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71966", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62434", "l": "a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine => a uridine in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67833", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36112", "l": "gibberellin A1 + S-adenosyl-L-methionine => O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047879", "l": "erythronolide synthase activity", "d": ["Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35689", "l": "3-oxotetradecasphinganine + H(+) + NADPH => NADP(+) + tetradecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14092", "l": "2-oxoglutarate + glycine <=> glyoxylate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62399", "l": "(1S,2S)-pseudoephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51057", "l": "A + androst-4-ene-3,17-dione => AH2 + androsta-1,4-diene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770187", "l": "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004385", "l": "guanylate kinase activity", "d": ["Catalysis of the reaction: ATP + GMP = ADP + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622134", "l": "CRABP1 binds atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14141", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + 2 glutathione", "d": [], "t": []}, {"i": "EC:1.8.4.9", "l": "\"adenylyl-sulfate reductase (glutathione)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69197", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653974", "l": "Ragulator binds Rag dimers (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714483", "l": "RAC2 translocates to the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77581", "l": "1-octanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38354", "l": "(R)-3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730840", "l": "Activation of RAC1 by VAV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39912", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate => (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796076", "l": "NFE2L2 dependent ABCG2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36711", "l": "ATP + H(+) + H2O + O-ureido-D-serine = ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.3.5", "l": "\"O-ureido-D-serine cyclo-ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69081", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37835", "l": "aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.180", "l": "\"aklavinone 12-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55468", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22073", "l": "ATP + L-ribulose => ADP + H(+) + L-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25047", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63340", "l": "ATP + L-amino acyl-L-seryl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102041", "l": "7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase", "d": ["Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77307", "l": "N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14392", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55758", "l": "a 2-hydroxyornithine lipid + CO2 + succinate => 2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.8", "l": "\"3-phytase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30874", "l": "2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36208", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18169", "l": "4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56690", "l": "(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29497", "l": "beta-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452701", "l": "Expression of DPPA4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63192", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.13.11.90", "l": "\"[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810376", "l": "ING2 binds PI5P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615249", "l": "ARBs bind AGRT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74538", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19741", "l": "formyl-CoA + H2O = CoA + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.10", "l": "\"formyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19862", "l": "a 16alpha-hydroxysteroid + NAD(+) => a 16-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645692", "l": "C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.151319539368089", "identifiers": [{"i": "GO:0016717", "l": "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water."], "t": []}, {"i": "EC:1.14.19.-", "l": "\"With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30293", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47725", "l": "glutathione => 5-oxo-L-proline + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57695", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052847", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "d": ["Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.4", "l": "\"alliin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57227", "l": "glyoxal + GTP <=> N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003832", "l": "beta-alanyl-dopamine hydrolase activity", "d": ["Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002059", "l": "thymine binding", "d": ["Binding to thymine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170149", "l": "Translocation of active Cdc25C to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418456", "l": "cGMP is degraded by PDEs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627072", "l": "RHOQ binds GOPC:CFTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23373", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52681", "l": "acetyl-CoA + L-alpha-phenylglycine => CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247844", "l": "WNT ligands traffic to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.372", "l": "\"D/L-glyceraldehyde reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77558", "l": "a 3-acyl-sn-glycerol + an acyl-CoA <=> a 1,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41341", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785607", "l": "FANCM binds FAAP24 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5635854", "l": "GLI2,3 are degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31029", "l": "beta-D-glucopyranosyl trans-(+)-abscisate + UDP => 2-trans-(+)-abscisate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77179", "l": "(5'S,6'R)-C-glycyluridine + O2 = CO2 + H2O + uridine-5'-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695834", "l": "Constitutive phosphorylation of FLT3 mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18866", "l": "2-methylpropanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] => CoA + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47593", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GP1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26194", "l": "(S)-malate + ATP + CoA => (S)-malyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15400", "l": "dichloromethane + H2O <=> 2 chloride + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73315", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) = 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19760", "l": "(3R)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33053", "l": "betaine aldehyde + H(+) + NADH => choline + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990380", "l": "K48-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11034", "l": "3-chloro-cis,cis-muconate + H(+) => (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19977", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": [], "t": []}, {"i": "EC:2.8.2.9", "l": "\"tyrosine-ester sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0008420", "l": "RNA polymerase II CTD heptapeptide repeat phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217136", "l": "Phosphorylation of Chk1 by ATM upon DNA damage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10804", "l": "(S)-allantoin = (R)-allantoin", "d": [], "t": []}, {"i": "EC:5.1.99.3", "l": "\"allantoin racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59034", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => (Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76981", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46146", "l": "(24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9846477", "l": "A4GALT transfers galactose to LacCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73579", "l": "(E,E)-piperoyl-AMP + CoA = (E,E)-piperoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34100", "l": "carboxynorspermidine + H(+) => CO2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37107", "l": "H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25115", "l": "H2O + pyridoxine 5'-phosphate <=> phosphate + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019141", "l": "2-dehydropantolactone reductase (B-specific) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35479", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64907", "l": "GTP + 2 H2O <=> GMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10671", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052724", "l": "inositol hexakisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10970", "l": "an acyl-CoA + GDP + phosphate => a carboxylate + CoA + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31625", "l": "H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine => L-olivosyl-oleandolide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67045", "l": "A + asnovolin H => AH2 + chermesin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64999", "l": "ATP + H(+) + octanoate <=> diphosphate + octanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005147", "l": "oncostatin-M receptor binding", "d": ["Binding to an oncostatin-M receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39810", "l": "octadecanoate(in) <=> octadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840581", "l": "GM1 localizes to endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984689", "l": "Kinesin-7 is a dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003726", "l": "double-stranded RNA adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38341", "l": "(20S)-ginsenoside Rd + D-glucose => (20S)-ginsenoside Rb1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.172", "l": "\"protein-ribulosamine 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954224", "l": "ERBB4s80:STAT5A binds CSN2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202459", "l": "Phosphorylation of Bcl10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59508", "l": "fumarate + L-cysteinyl-[protein] = S-(2-succinyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64612", "l": "ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56176", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O = 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.1", "l": "\"5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433374", "l": "Processing of SCF isoform 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655243", "l": "Activated FGFR3 point and translocation mutants phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66167", "l": "butanoyl-CoA + serotonin <=> CoA + H(+) + N-butanoylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690873", "l": "ACO1 binds 4Fe-4S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48803", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164504", "l": "Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683792", "l": "p-T68-CHEK2 autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358790", "l": "RNF41 ubiquitinates ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43689", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate => L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65656", "l": "A + cholest-1,4-dien-3-one + H2O = 25-hydroxycholest-1,4-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.421949063212963", "identifiers": [{"i": "GO:0140101", "l": "catalytic activity, acting on a tRNA", "d": ["Catalytic activity that acts to modify a tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106339", "l": "tRNA (cytidine(32)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytosine32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39734", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19091", "l": "H(+) + precorrin-1 + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uroporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27904", "l": "1,3,7-trimethylurate + ubiquinol-0 => caffeine + H2O + ubiquinone-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63342", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59592", "l": "ATP + beta-alanine + L-arginine = ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58994", "l": "(E)-cinnamate + H(+) + H2O2 => (E)-cinnamaldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034790", "l": "3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193653", "l": "NGF homodimer binds to p75NTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12301", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) => 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16039", "l": "2-deoxy-alpha-D-ribose 1-phosphate + thymine => phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48276", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69140", "l": "RPA binds to the Flap (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447034", "l": "CHL1 interacts with Ankyrin-G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140767", "l": "enzyme-substrate adaptor activity", "d": ["An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27270", "l": "CoA + hexadecanal + NADP(+) = H(+) + hexadecanoyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47922", "l": "ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)/18:0) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072371", "l": "histone H2AS121 kinase activity", "d": ["Catalysis of the reaction: histone H2A-serine (position 121) + ATP = histone H2A-phosphoserine (position 121) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 121 of histone H2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299338", "l": "Activation of TRESK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102820", "l": "norbixin methyltransferase activity", "d": ["Catalysis of the reaction: norbixin + S-adenosyl-L-methionine = bixin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70974", "l": "D-dopa + H2O + O2 <=> 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835443", "l": "STAT1,STAT3 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797553", "l": "Protein 4.1 binds CASK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65413", "l": "dAMP(in) + NAD(+)(out) => dAMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38581", "l": "(20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174445", "l": "RPA binds to the Flap on the C-strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35853", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52802", "l": "AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid => acetoacetyl-CoA + ATP + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010091", "l": "APP translocates from plasma membrane to endosome lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77081", "l": "Formation of the CE:GMP intermediate complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31083", "l": "H2O + N-acetyl-D-muramoyl-L-alanine = L-alanine + N-acetyl-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35959", "l": "H(+) + NADPH + O2 + tryprostatin B = demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40959", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65744", "l": "2-oxoglutarate + decyl sulfate + O2 = CO2 + decanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50590", "l": "15-oxoprostaglandin F2alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-PGF2alpha + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25630", "l": "myricetin + S-adenosyl-L-methionine => H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362416", "l": "Frataxin binds iron (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70449", "l": "a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34005", "l": "7-dehydrodesmosterol + 2 H2O + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19515", "l": "H(+) + L-citrulline + phosphate => carbamoyl phosphate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70100", "l": "H(+) + o-quinone methide + peniphenone D => penilactone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74552", "l": "H2O + L-seryl-tRNA(Ser) => L-serine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77381", "l": "CO2 + tridecane => H(+) + hnu + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458433", "l": "Collagen type I degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031748", "l": "D1 dopamine receptor binding", "d": ["Binding to a D1 dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19598", "l": "H2O + L-arginine => L-citrulline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58207", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849085", "l": "ARHGAP35 binds RHOA:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40659", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69404", "l": "uracil(in) = uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77077", "l": "Capping complex formation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67360", "l": "H2O + L-threonyl-L-threonine = 2 L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804762", "l": "TP53 forms homotetramers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2219524", "l": "PDPK1 binds PIP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76985", "l": "(9Z)-octadecenoate + 2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+) => 1-(9Z-octadecenoyl)-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665708", "l": "ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28713", "l": "H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out) => H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73126", "l": "isorhamnetin + S-adenosyl-L-methionine <=> H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16943", "l": "H2O + N-acetylisatin => N-acetylindoxyl + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11679", "l": "D-ribose + H2O + NADP(+) <=> D-ribonate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015306", "l": "sialate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74928", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] => (2E)-butenoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73324", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA => cimicifugate D + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419011", "l": "Transhomodimerization of Nectins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14925", "l": "D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.224", "l": "\"mannose-6-phosphate 6-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25368", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) => H(+) + momilactone A + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805470", "l": "AMPK phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46568", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76756", "l": "decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,3-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034787", "l": "1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938887", "l": "PML binds RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71923", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54567", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41676", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76827", "l": "butylamine + H2O + NAD(+) = butanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111879", "l": "PIP2 hydrolysis (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60777", "l": "2-oxoglutarate + gibberellin A12 + O2 => CO2 + gibberellin A15 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21983", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855203", "l": "5-PP-IP5 transports from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69581", "l": "dGMP + inosine => 2'-deoxyguanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60771", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 <=> 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.4", "l": "\"signal-recognition-particle GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685281", "l": "SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66732", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972960", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220982", "l": "NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2301205", "l": "SETD8 monomethylates histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15941", "l": "H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine", "d": [], "t": []}, {"i": "EC:3.5.1.16", "l": "\"acetylornithine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74011", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 = [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58571", "l": "15alpha-stemmadenine + acetyl-CoA <=> CoA + O-acetyl-15alpha-stemmadenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607751", "l": "TRAF6 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21443", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 <=> a long-chain alkane + formate + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005328", "l": "neurotransmitter:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474210", "l": "Collagen type III degradation by MMP14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.155", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114544", "l": "p115-RhoGEF activation of RHOA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40843", "l": "FAD + H(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015111", "l": "Factor Xa inhibitors binds Xa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32221", "l": "gamma-carotene => all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052829", "l": "inositol-1,3,4-trisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17661", "l": "ATP + CoA + succinate = ADP + phosphate + succinyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.5", "l": "\"succinate--CoA ligase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015148", "l": "D-xylose transmembrane transporter activity", "d": ["Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13044", "l": "L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873946", "l": "OTUD3 deubiquitinates PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25906", "l": "dehypoxanthine futalosine + hypoxanthine => futalosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50902", "l": "(10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189439", "l": "ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75536", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 => (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047117", "l": "enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625421", "l": "The anterograde IFT train dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76701", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661219", "l": "MT1A binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222093", "l": "BRD7 binds TP53 and EP300 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247844", "l": "WNT ligands traffic to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45165", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60870", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004997", "l": "thyrotropin-releasing hormone receptor activity", "d": ["Combining with thyrotropin-releasing hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43668", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate = 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114264", "l": "Translocation of activated BAX to the mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15488", "l": "(2R,3S)-homoisocitrate <=> cis-homoaconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804100", "l": "HMGB1 binds LPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19199", "l": "adenosine 5'-phosphoramidate + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534096", "l": "METAP1/2 demethylates GNAT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373741", "l": "SDK2 homophillic interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20220", "l": "H(+) + trimethylamine N-oxide <=> dimethylamine + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24571", "l": "a 6-phospho-beta-D-galactoside + H2O <=> an alcohol + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944236", "l": "Association of procollagen type XIV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592387", "l": "Fibulin binds elastic fibres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0000908", "l": "taurine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53585", "l": "NAD(+) + resolvin D2 => 7-oxoresolvin D2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24103", "l": "diisopropyl fluorophosphate + H2O <=> diisopropyl phosphate + fluoride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58481", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001001", "l": "mitochondrial single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60051", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2328037", "l": "Fibrillin-1 binds integrins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74449", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29927", "l": "(R)-pantothenate(in) + Na(+)(in) = (R)-pantothenate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68072", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH = L-thiazolidine-2-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32561", "l": "diphosphate + gamma-terpinene => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.57", "l": "\"taurochenodeoxycholate 6alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64066", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2R)-pseudoephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34489", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+) => dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47831", "l": "a ganglioside GT1b + H2O <=> a ganglioside GD1b + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62907", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73383", "l": "thiamine diphosphate(in) + thiamine phosphate(out) = thiamine diphosphate(out) + thiamine phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13743", "l": "indole-3-pyruvate + L-phenylalanine => 3-phenylpyruvate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670014", "l": "Factor VIIIa dissociates  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0030414", "l": "peptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62742", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73441", "l": "(2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63534", "l": "angiotensin-(1-9) + L-leucine => angiotensin I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031927", "l": "pyridoxamine transmembrane transporter activity", "d": ["Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40417", "l": "2,6,10,14-tetramethylpentadecanoate + CoA + H(+) => H2O + pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56214", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14728", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72663", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54599", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 <=> 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072550", "l": "triferuloylspermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56804", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803230", "l": "Dissociation of moderate activity BRAF complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9609921", "l": "SGTA binds Tail-anchored protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29795", "l": "ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": [], "t": []}, {"i": "EC:7.2.2.20", "l": "\"ABC-type Zn(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34989", "l": "(S)-lactate(out) => (S)-lactate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55080", "l": "ADP-alpha-D-glucose + D-fructose = ADP + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380048", "l": "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25258", "l": "N-acetyl-D-glucosamine 6-phosphate => N-acetyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33802", "l": "L-histidinol + NAD(+) <=> H(+) + L-histidinal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76679", "l": "CoA + NAD(+) + sulfoacetaldehyde = H(+) + NADH + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981621", "l": "Neuroglobin:oxygen dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20846", "l": "ADP + H(+) + oxaloacetate + phosphate => ATP + hydrogencarbonate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13623", "l": "1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose => 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213195", "l": "Formation of anchoring fibrils (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51228", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate = 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:0016743", "l": "carboxyl- or carbamoyltransferase activity", "d": ["Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.1.3.-", "l": "\"Carboxy- and carbamoyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76486", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15757", "l": "L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653936", "l": "Formation of Ragulator complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73240", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether => H(+) + ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32016", "l": "(2E,6E)-farnesyl diphosphate => (-)-delta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033998", "l": "inulin fructotransferase (DFA-III-forming) activity", "d": ["Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32730", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452331", "l": "Expression of TBXT (T, Brachyury) in the primitive streak (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193656", "l": "p75NTR interacts with RIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16737", "l": "H(+) + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.11", "l": "\"toluene dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40222", "l": "H2O + malonyl-CoA <=> CoA + H(+) + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668904", "l": "Formation of the CTF18 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69028", "l": "5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33042", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29202", "l": "(S)-dihydroorotate + menaquinone-8 <=> menaquinol-8 + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75106", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043798", "l": "glycerate 2-kinase activity", "d": ["Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17495", "l": "AH2 + dihydroxyacetone => A + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76778", "l": "decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,7-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043560", "l": "insulin receptor substrate binding", "d": ["Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16569", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.4", "l": "\"procollagen-lysine 5-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60508", "l": "a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170159", "l": "Translocation of Cdc25 to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40686", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol <=> 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36466", "l": "glycyl-L-glutamate + H2O <=> glycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35160", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27877", "l": "isochorismate <=> pyruvate + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25594", "l": "2-oxoglutarate + H(+) + isochorismate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16758", "l": "NADP(+) + trypanothione => H(+) + NADPH + trypanothione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705584", "l": "HMGCR dimer binds statins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014433", "l": "RHOG GEFs activate RHOG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32372", "l": "all-trans-violaxanthin + 2 L-ascorbate => all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46080", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH = NAD(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050352", "l": "trimethylamine-oxide aldolase activity", "d": ["Catalysis of the reaction: H+ + trimethylamine N-oxide = dimethylamine + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37928", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54650", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74338", "l": "O-2-methylbutanoyl-(R)-carnitine(in) <=> O-2-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44507", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate <=> a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70376", "l": "3-oxosphinganine + dodecanoyl-CoA => CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69751", "l": "benzylmalonyl-CoA + H(+) + O2 = (E)-cinnamoyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004771", "l": "sterol esterase activity", "d": ["Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41455", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 <=> 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917730", "l": "Cargo Recognition And Sorting (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53574", "l": "20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799409", "l": "HIPK2 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41729", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68458", "l": "(2E)-glutaconyl-CoA + H2O => (S)-3-hydroxyglutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849055", "l": "PTK6 binds ARHGAP35 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617838", "l": "CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23800", "l": "H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)", "d": [], "t": []}, {"i": "EC:4.4.1.11", "l": "\"methionine gamma-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32019", "l": "(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.128", "l": "\"beta-cubebene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23985", "l": "cholesterol + NADP(+) => 7-dehydrocholesterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35125", "l": "H(+)(in) + L-alanyl-D-glutamate(in) => H(+)(out) + L-alanyl-D-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15463", "l": "3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2301205", "l": "SETD8 monomethylates histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49594", "l": "(3S)-3-hydroxybutanoyl-CoA => 2-hydroxyisobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26038", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033854", "l": "glutamate-prephenate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14107", "l": "1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66957", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9609921", "l": "SGTA binds Tail-anchored protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15497", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.56", "l": "\"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448632", "l": "IL34 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74138", "l": "petunidin + UDP-alpha-D-galactose <=> petunidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61990", "l": "5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982703", "l": "PKC binds active G alpha (z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784204", "l": "JAKs bind OSMR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22473", "l": "(R)-pantetheine + ATP => (R)-4'-phosphopantetheine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59445", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A => 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004366", "l": "glycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45271", "l": "4'-hydroxyechinenone + AH2 + O2 <=> 4',4'-dihydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781001", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15521", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": [], "t": []}, {"i": "EC:2.3.1.97", "l": "\"glycylpeptide N-tetradecanoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853793", "l": "p-5Y-RET complexes bind GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40165", "l": "(R)-glycerate + 2 H(+) + NADPH => D-glyceraldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68271", "l": "dUMP + formaldehyde + H(+) + NADPH <=> dTMP + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62339", "l": "AMP + ATP <=> adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009817", "l": "Acitretin binds to RAR:RXR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65459", "l": "2-methylbutan-1-ol + acetyl-CoA <=> 2-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109813", "l": "GRB2-1 binds SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45959", "l": "(9Z)-octadecenoyl-CoA(in) <=> (9Z)-octadecenoyl-CoA(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34295", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38934", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034925", "l": "pyrene 4,5-monooxygenase activity", "d": ["Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18003", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68959", "l": "S-adenosyl-L-methionine + scopoletin <=> H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55841", "l": "calcidiol + UDP-alpha-D-glucuronate => calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51117", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634228", "l": "TRAF1 is cleaved by caspases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45707", "l": "(E)-sinapyl alcohol + NADP(+) <=> (E)-sinapaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52280", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.247", "l": "\"codeinone reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10582", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005304", "l": "L-valine transmembrane transporter activity", "d": ["Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23828", "l": "2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.274", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57806", "l": "4-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047080", "l": "deoxyuridine 2'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205319", "l": "Interaction of APS and p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0003713", "l": "transcription coactivator activity", "d": ["A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23726", "l": "4-pyridoxate + H(+) + H2O2 => H2O + O2 + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0070717", "l": "poly-purine tract binding", "d": ["Binding to a stretch of purines (adenine or guanine) in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51998", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61410", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine => ATP + N(6)-(D-erythrulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67377", "l": "glycyl-L-histidine + H2O => glycine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45174", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986940", "l": "MET gene transcription is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357472", "l": "PAK1-3 autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692749", "l": "CDC14A,B bind MAPK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20572", "l": "H2O + L-arginine <=> L-ornithine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987007", "l": "p-STAT1 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38399", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66351", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26074", "l": "H2O + UDP-alpha-D-glucuronate => D-glucuronate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69510", "l": "H(+) + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44834", "l": "CoA + O-tetradecanoyl-(R)-carnitine => (R)-carnitine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470009", "l": "Phosphorylation of STATs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59130", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate => (S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38872", "l": "uridine(2457) in 23S rRNA => pseudouridine(2457) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52187", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654163", "l": "Activated FGFR4 binds PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159773", "l": "Furin cleaves pro-protein S to protein S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67704", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928640", "l": "PAKs phosphorylate MLC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60950", "l": "(S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine => (S)-eriodictyol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848774", "l": "PTK6 binds DOK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022065", "l": "DSPGs are secreted (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948136", "l": "ULK1 Translocates to the mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74730", "l": "Insulin degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211651", "l": "Cleavage of PAK-2 at 212 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71324", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) => chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362416", "l": "Frataxin binds iron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42177", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791109", "l": "GADD45A binds PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27570", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.168", "l": "\"D-glycero-alpha-D-manno-heptose-7-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71825", "l": "3,3'-diiodo-L-thyronine(in) => 3,3'-diiodo-L-thyronine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55225", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783880", "l": "PIPOX oxidises PPCA to P6C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035446", "l": "cysteine-glucosaminylinositol ligase activity", "d": ["Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18124", "l": "an S-substituted L-cysteine + H2O <=> a thiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19535", "l": "CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+) => 2 H(+) + 2 H2O + N(2)-succinyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13779", "l": "5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate => ATP + D-ribose 5-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008830", "l": "dTDP-4-dehydrorhamnose 3,5-epimerase activity", "d": ["Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647994", "l": "RAS proteins are depalmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51456", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine = (9Z)-octadecenoate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199299", "l": "AKT phosphorylates FOXO transcription factors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59267", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030267", "l": "glyoxylate reductase (NADP+) activity", "d": ["Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53185", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68571", "l": "N(5)-hydroxy-L-ornithine <=> (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373889", "l": "lactate + H+ [cytosol] <=> lactate + H+ [extracellular] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20918", "l": "hydrogen sulfide + L-cysteate => L-cysteine + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24016", "l": "16-epivellosimine + acetyl-CoA = CoA + vinorine", "d": [], "t": []}, {"i": "EC:2.3.1.160", "l": "\"vinorine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40966", "l": "4 2-aminophenol + 3 O2 <=> 2 2-aminophenoxazin-3-one + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65010", "l": "decanoyl-AMP + diphosphate => ATP + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707516", "l": "FeHM dissociates from MetHb (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099899", "l": "WNT5A binds FZD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050070", "l": "lysolecithin acylmutase activity", "d": ["Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047795", "l": "cyclohexane-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187264", "l": "Platelet glycoprotein IV (CD36) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683774", "l": "p-T68-CHEK2 dimerizes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181352", "l": "LEFTY binds NODAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399992", "l": "AKT1 E17K mutant phosphorylates forkhead box transcription factors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75079", "l": "Formation of AT-AC C complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44587", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.3", "l": "\"glucan 1,4-alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38267", "l": "2-methylfumaryl-CoA = 3-methylfumaryl-CoA", "d": [], "t": []}, {"i": "EC:5.4.1.3", "l": "\"2-methylfumaryl-CoA isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22092", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] = 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.3", "l": "\"phycoerythrobilin:ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19171", "l": "NH4(+) + pyruvate => L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018697", "l": "carbonyl sulfide nitrogenase activity", "d": ["Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.74", "l": "\"(+)-piperitol/(+)-sesamin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42710", "l": "N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine => guanosine(46) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72041", "l": "nicotinate(out) + orotate(in) => nicotinate(in) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41318", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047203", "l": "13-hydroxylupinine O-tigloyltransferase activity", "d": ["Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31998", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epi-sesquithujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.49", "l": "\"RNA-directed DNA polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.65", "l": "\"levanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004054", "l": "arginine kinase activity", "d": ["Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018826", "l": "RHOT2 hydrolyzes GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18011", "l": "CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein] => glutaryl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.299", "l": "\"protein N-terminal monomethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27363", "l": "chloromethane + S-adenosyl-L-homocysteine => chloride + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71545", "l": "5-phosphomethyl-dUMP in DNA + ADP + H(+) => 5-hydroxymethyl-dUMP in DNA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44877", "l": "a 1,3-diacylglycerol + H2O => a 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44705", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.74", "l": "\"pyridoxal phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65207", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O <=> (R)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66803", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69718", "l": "(indol-3-yl)acetate + ATP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65224", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46646", "l": "5beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004830", "l": "tryptophan-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75069", "l": "chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052609", "l": "4-ketotorulene 3-hydroxylase activity", "d": ["Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28169", "l": "5-nitroanthranilate + H(+) + H2O <=> 5-nitrosalicylate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65537", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theacrine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950623", "l": "Expression of Carbonic anhydrase 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60024", "l": "(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030747", "l": "indolepyruvate C-methyltransferase activity", "d": ["Catalysis of the reaction: indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53845", "l": "glycochenodeoxycholate + NAD(+) => 7-oxoglycolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350186", "l": "CUBN binds GC:25(OH)D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2002460", "l": "P4HB binds Collagen chains (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050025", "l": "L-glutamate oxidase activity", "d": ["Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877361", "l": "Pyrin binds ASC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66195", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O <=> ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640195", "l": "RRAGA,B hydrolyzes GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036131", "l": "prostaglandin D2 11-ketoreductase activity", "d": ["Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034911", "l": "phthalate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942302", "l": "MMP13 cleaves OPTC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43059", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12569", "l": "4-nitrophenol + H(+) + NADH + O2 => 4-nitrocatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39795", "l": "7beta-hydroxycholesterol(in) + ATP + H2O = 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0030611", "l": "arsenate reductase activity", "d": ["Catalysis of the interconversion of arsenate and arsenite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72180", "l": "Cleavage of mRNA at the 3'-end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69116", "l": "Formation of Okazaki fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69491", "l": "O2 + tetradecan-1-ol <=> H2O2 + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56776", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55084", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O = (3R)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483174", "l": "PE is methylated to PC by PEMT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51147", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 <=> (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75062", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71965", "l": "(R)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (R)-2-hydroxyglutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16593", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.88", "l": "\"8-hydroxyquercetin 8-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17746", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55485", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051265", "l": "diolein transacylation activity", "d": ["Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10854", "l": "diphosphate + sophoraflavanone G => dimethylallyl diphosphate + leachianone G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39599", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610752", "l": "GLI3R translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851933", "l": "MET phosphorylates GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866851", "l": "CFTR transits to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44096", "l": "decan-1-ol + hexadecanoyl-CoA = CoA + decanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.85", "l": "\"6-phospho-beta-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37447", "l": "O2 + tetracenomycin F1 = H(+) + H2O + tetracenomycin D3", "d": [], "t": []}, {"i": "EC:1.13.12.21", "l": "\"tetracenomycin-F1 monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51784", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate = deoxyhumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16963", "l": "5-oxo-L-proline + L-lysine => epsilon-(gamma-L-glutamyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019112", "l": "phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68235", "l": "L-cysteine(in) + Na(+)(in) <=> L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033679", "l": "3'-5' DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60107", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] <=> (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28434", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] = ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848023", "l": "Activated PTK6 binds STAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213246", "l": "Disassociation of CLIP from MHC II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102967", "l": "10-hydroxygeraniol oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP = (6E)-8-hydroxygeranial + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381668", "l": "cAMP activates EPAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24970", "l": "H2O + 2 oxidized [adrenodoxin] + secalciferol => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217152", "l": "Formation of a multi-protein complex, cohesin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23540", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": [], "t": []}, {"i": "EC:6.1.1.17", "l": "\"glutamate--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34975", "l": "(R)-pantothenate(in) = (R)-pantothenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13068", "l": "ATP + H2O <=> ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247843", "l": "secretion of WNT ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61958", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209097", "l": "ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36303", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193665", "l": "MYD88 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751040", "l": "PKC phosphorylates G alpha (z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047561", "l": "3-hydroxyanthranilate oxidase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730902", "l": "Oligomerization of p-CARMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448632", "l": "IL34 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11122", "l": "2 CO2 + NH4(+) => cyanate + 3 H(+) + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66908", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine = 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45039", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine <=> 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877361", "l": "Pyrin binds ASC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.111", "l": "\"3-(imidazol-5-yl)lactate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109858", "l": "MAP2K2 binds MAPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21398", "l": "CO2 + Na(+)(out) + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684052", "l": "PIAS4 SUMOylates MDC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106271", "l": "D-arabinose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-500708", "l": "GRIK3 homomer binds glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382057", "l": "Release of novel PDGFs as latent factors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450031", "l": "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14823", "l": "L-ribulose => beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101021", "l": "estrogen 2-hydroxylase activity", "d": ["Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617595", "l": "SGTA binds mislocalized membrane protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20311", "l": "2 H2O + O2 => 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61869", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27756", "l": "(R)-lactate + H(+) => H2O + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34939", "l": "H2O + menaquinone-8 + selenite = menaquinol-8 + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61645", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72499", "l": "2-oxoglutarate(in) + prostaglandin E2(out) = 2-oxoglutarate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77266", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(in) <=> beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12068", "l": "apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.7.8.7", "l": "\"holo-[acyl-carrier-protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768829", "l": "SRF stimulates NPAS4 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10896", "l": "2 H2O + limonin = 2 H(+) + limonoate", "d": [], "t": []}, {"i": "EC:3.1.1.36", "l": "\"limonin-D-ring-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682826", "l": "LGI1 binds ADAM11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29491", "l": "(2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74400", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) => 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67024", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.296", "l": "\"methyltransferase cap2\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77123", "l": "1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,3-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177934", "l": "EGFR autophosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45222", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050641", "l": "6-methylsalicylic acid synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + 3 H+ + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964311", "l": "G alpha (i):GTP binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13411", "l": "7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH => 7-aminomethyl-7-carbaguanine + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52117", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20110", "l": "alpha-D-ribose 1,5-bisphosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18814", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate => (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63162", "l": "(15Z)-tetracosenoate + taurine => H2O + N-(15Z-tetracosenoyl)-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19229", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic carboxylate + ATP + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.30", "l": "\"carboxylate reductase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549129", "l": "OCT1 transports organic cations into hepatic cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810392", "l": "TMEM55B translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60715", "l": "(+)-artemisinic alcohol + NAD(+) <=> (+)-artemisinic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690493", "l": "RHOB binds effectors on endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029456", "l": "RAC1 and CDC42 activate PAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21921", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37725", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102276", "l": "2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ = ethene + 3 carbon dioxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37271", "l": "ATP + H2O + L-alanyl-L-glutamine(out) = ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68815", "l": "(2Z,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77669", "l": "a globoside GlcNAc-GalGb4Cer (d18:1(4E)) + H(+) + UDP => a globoside GalGb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.938801239267953", "identifiers": [{"i": "GO:0001664", "l": "G protein-coupled receptor binding", "d": ["Binding to a G protein-coupled receptor."], "t": []}, {"i": "REACT:R-HSA-500717", "l": "Activation of GRIK3 homomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63463", "l": "(2E,6E,10E)-geranylgeraniol + GTP <=> (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102814", "l": "caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA = delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21825", "l": "2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372529", "l": "Release of acetylcholine at the synapse (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28945", "l": "glycine betaine(out) => glycine betaine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69646", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 <=> (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380508", "l": "Translocation of NuMA to the centrosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16846", "l": "acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55388", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14616", "l": "ATP + H2O + taurine(out) <=> ADP + H(+) + phosphate + taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16069", "l": "cytidine + H(+) + H2O = NH4(+) + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400009", "l": "PI3K inhibitors block PI3K catalytic activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373734", "l": "Nephrin interacts with Podocin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59769", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009671", "l": "nitrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692738", "l": "HRH2 binds HRH2 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11422", "l": "H2O + NADP(+) + senecionine N-oxide => NADPH + O2 + senecionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18543", "l": "dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine => 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40571", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870466", "l": "RGGT:CHM binds RABs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14451", "l": "3,8-divinyl chlorophyllide a + H(+) + NADPH => chlorophyllide a + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035276", "l": "ethanol binding", "d": ["Binding to ethanol, CH(3)-CH(2)-OH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674095", "l": "PDGFRs bind type II TKI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67315", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27830", "l": "neryl diphosphate = beta-phellandrene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.51", "l": "\"beta-phellandrene synthase (neryl-diphosphate-cyclizing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41007", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin = 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.124", "l": "\"6-linalyl-2-O,3-dimethylflaviolin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35524", "l": "H(+) + N-ethylmaleimide + NADPH => N-ethylsuccinimide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177922", "l": "EGFR dimerization (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41672", "l": "1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22099", "l": "phosphate + RNA(n+1) <=> a ribonucleoside 5'-diphosphate + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58522", "l": "akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20804", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034279", "l": "syn-pimara-7,15-diene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69164", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) = 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72772", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48438", "l": "an aliphatic alcohol + H(+) + pentanoate => H2O + pentanoate ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834890", "l": "TFAP2A:TFAP2C binds the MSX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608048", "l": "Expression of PLIN1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015633", "l": "ABC-type zinc transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102135", "l": "(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 = (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008984", "l": "protein-glutamate methylesterase activity", "d": ["Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15819", "l": "H2O2 + NH4(+) + pyridoxal 5'-phosphate => H2O + O2 + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41761", "l": "a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GD3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001147", "l": "transcription termination site sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26454", "l": "NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.84", "l": "\"acrylyl-CoA reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74715", "l": "Autophosphorylation of insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45762", "l": "dTDP + H(+) + rhodomycin D => dTDP-beta-L-daunosamine + epsilon-rhodomycinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0004102", "l": "choline O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40978", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12609", "l": "mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61639", "l": "ATP + CoA + isophthalate <=> AMP + diphosphate + isophthalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507719", "l": "p62:MEKK3 binds to TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205649", "l": "p62 links damaged mitochondria to LC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168136", "l": "Activated JNKs phosphorylate c-JUN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10139", "l": "2 glyoxylate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187506", "l": "Translocation of p27 to the nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65924", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36969", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674022", "l": "BRAP autoubiquitinates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112435", "l": "Formation of Elongin BC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855232", "l": "RELN:VLDLR binds DAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45020", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.298", "l": "\"ribosomal protein uL3 N(5)-glutamine methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031692", "l": "alpha-1B adrenergic receptor binding", "d": ["Binding to an alpha-1B adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2067713", "l": "GP369 inhibits activation of amplified FGFR2 signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990478", "l": "Kinesin-14 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41093", "l": "1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24293", "l": "acetyl-CoA + L-glutamate => CoA + H(+) + N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41088", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60185", "l": "ATP + D-glucose(out) + H2O => ADP + D-glucose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65737", "l": "2-oxoglutarate + O2 + octyl sulfate => CO2 + H(+) + octanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.315929082021214", "identifiers": [{"i": "GO:0030246", "l": "carbohydrate binding", "d": ["Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62012", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748991", "l": "XDH oxidises 6MP to 6TU (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112514", "l": "JAK activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43594", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral => all-trans-zeaxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75851", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450488", "l": "BRF1 Complex recruits RNA degradation activities (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34207", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate = beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:2.4.1.282", "l": "\"3-O-alpha-D-glucosyl-L-rhamnose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696457", "l": "BDH2 dehydrogenates 3HBA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717202", "l": "GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0008301", "l": "DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047507", "l": "(deoxy)nucleoside-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64976", "l": "8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174224", "l": "Dissociation of Cdc20 from APC/C complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56088", "l": "a globoside MSGG + CMP-N-acetyl-beta-neuraminate = a globoside DSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835328", "l": "NPM binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37711", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446694", "l": "IRAK4 phosphorylates IRAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22269", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-555065", "l": "Formation of clathrin coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10035", "l": "[protein]-C-terminal-L-glutamine + H2O <=> [protein]-C-terminal-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36123", "l": "gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51436", "l": "acetyl-CoA + D-alanine = (2R)-2-amino-4-oxopentanoate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.263", "l": "\"2-amino-4-oxopentanoate thiolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0004169", "l": "dolichyl-phosphate-mannose-protein mannosyltransferase activity", "d": ["Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77098", "l": "5-S-cysteinyldopa + L-dopaquinone <=> 5-S-cysteinyldopaquinone + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30038", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75517", "l": "acetate + L-cysteine => H2O + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43610", "l": "2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate => agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17910", "l": "(S)-lactate => acetaldehyde + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990275", "l": "preribosome binding", "d": ["Binding to a preribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371590", "l": "HSP70 binds to HSP40:nascent protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62199", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol <=> acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24098", "l": "H(+) + isoscoparin + S-adenosyl-L-homocysteine => isoorientin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24423", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] <=> formate + N-terminal L-methionyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008579", "l": "JUN kinase phosphatase activity", "d": ["Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36172", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol => 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070780", "l": "dihydrosphingosine-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10956", "l": "(E)-cinnamate + H(+) + NADPH + O2 = H2O + NADP(+) + trans-2-coumarate", "d": [], "t": []}, {"i": "EC:1.14.13.14", "l": "\"trans-cinnamate 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851919", "l": "Activated MET binds GAB1 and GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72678", "l": "3',5'-cyclic CMP + H2O <=> CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48896", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55897", "l": "chloride + FADH2 + L-tryptophan + O2 => 5-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49394", "l": "20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69252", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = 2-(thiiran-2-yl)acetonitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54055", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + tau-cadinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686430", "l": "MUS81 binds EME1, EME2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0032038", "l": "myosin II heavy chain binding", "d": ["Binding to a heavy chain of a myosin II complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34056", "l": "festuclavine + NAD(+) => 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31860", "l": "(S)-2,3-epoxysqualene => glutinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080041", "l": "ADP-ribose pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202222", "l": "Phosphorylation of PKC theta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873850", "l": "STARD5 binds DCA, LCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034714", "l": "type III transforming growth factor beta receptor binding", "d": ["Binding to a type III transforming growth factor beta receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34495", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62276", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine = 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43883", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA <=> (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58372", "l": "(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40369", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21722", "l": "H2O + hydrogen cyanide => formamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008873", "l": "gluconate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31634", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate <=> phosphate + pseudaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373177", "l": "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14684", "l": "2 2-aminophenol + A + O2 <=> 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38867", "l": "uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.19", "l": "\"16S rRNA pseudouridine(516) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034529", "l": "2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34957", "l": "5-(methylsulfanyl)-D-ribose(out) => 5-(methylsulfanyl)-D-ribose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64970", "l": "dUDP + H(+) + phosphate => dUTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30283", "l": "(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.88", "l": "\"pyrethroid hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804741", "l": "MDM2 forms homo- or heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447219", "l": "IL17RA and IL17RB bind IL25 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372529", "l": "Release of acetylcholine at the synapse (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18458", "l": "D-ribulose 5-phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66948", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate = alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.303", "l": "\"alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und 2(IV)-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34275", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:1.1.99.38", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033900", "l": "ribonuclease F activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71490", "l": "H2O + Leu-enkephalin <=> L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64775", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114671", "l": "vWF binds to collagen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64218", "l": "CO2 + L-lyxonate => 2-carboxy-L-lyxonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12027", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline <=> D-glucose + O-sinapoylcholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102868", "l": "24-epi-campsterol desaturase activity", "d": ["Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 = brassicasterol + NADP + 2 H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840408", "l": "OMA1 cleaves DELE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46114", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36795", "l": "a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032327", "l": "5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15056", "l": "(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55973", "l": "acetyl-CoA + ethanol => CoA + ethyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30109", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => D-serine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72210", "l": "chloride(out) + 2 hydrogencarbonate(in) <=> chloride(in) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.4", "l": "\"poly(A)-specific ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23150", "l": "ADP + propanoyl phosphate => ATP + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52099", "l": "9-octadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69053", "l": "RFC binding displaces Pol Alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44588", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23942", "l": "5-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44131", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937177", "l": "AHR:TCDD binds ARNT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018814", "l": "phenylacetaldoxime dehydratase activity", "d": ["Catalysis of the reaction: (trans)-phenylacetaldoxime = H2O + phenylacetonitrile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60194", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73276", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine => 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805546", "l": "Keratin type I binds keratin type II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34823", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + curcumin", "d": [], "t": []}, {"i": "EC:2.3.1.217", "l": "\"curcumin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24296", "l": "(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.2.3", "l": "\"dihydroorotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59347", "l": "D-maltose + O2 <=> D-maltobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.87", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69792", "l": "D-phenylalanyl-tRNA(Phe) + H2O => D-phenylalanine + H(+) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56438", "l": "2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209738", "l": "VD3 binds GC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35695", "l": "(3S)-versiconol acetate + NADP(+) = (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47709", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) => ADP-alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76814", "l": "(S)-methioninol + H2O + NAD(+) <=> 1-hydroxy-4-(methythio)butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33246", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507873", "l": "Aquaporins passively transport urea out of cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661419", "l": "ALB binds extracellular heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51868", "l": "dimethylallyl diphosphate + umbelliferone = demethylsuberosin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74750", "l": "myricetin + S-adenosyl-L-methionine <=> 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374337", "l": "Apelin receptor binds to apelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802911", "l": "High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102775", "l": "6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity", "d": ["Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30434", "l": "(S)-2,3-epoxysqualene <=> taraxerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53543", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868071", "l": "Clathrin recruits PIK3C2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168136", "l": "Activated JNKs phosphorylate c-JUN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928640", "l": "PAKs phosphorylate MLC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44661", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73489", "l": "a carboxylate(out) + orotate(in) => a carboxylate(in) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43888", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine = [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28090", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.33", "l": "\"UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28609", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696958", "l": "USP44 deubiquitinates CDC20 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0033558", "l": "protein lysine deacetylase activity", "d": ["Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.21", "l": "\"glycerol-1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61741", "l": "steviolmonoside + UDP-alpha-D-glucose => H(+) + steviolbioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65603", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) <=> 2 H(+) + jolkinol C + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74151", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": [], "t": []}, {"i": "EC:2.3.1.309", "l": "\"[beta-tubulin]-L-lysine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190682", "l": "Connexin synthesis (generic) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62726", "l": "(+)-isomalbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25287", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29910", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56643", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57377", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61710", "l": "AMP + L-seryl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-seryl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37372", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67322", "l": "sch 210971 => (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865276", "l": "PDGF-AB clevage by Furin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.26", "l": "\"rhodotorulapepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73797", "l": "FAICAR => IMP + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166220", "l": "FA anion diffuses laterally to UCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33986", "l": "(+)-copalyl diphosphate <=> diphosphate + miltiradiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45674", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27560", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.96", "l": "\"4-aminobutyrate--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47880", "l": "dioctanoylglycerol + H2O = H(+) + octanoate + octanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20308", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) <=> 4-hydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31782", "l": "an all-trans-retinyl ester + H2O <=> 13-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018578", "l": "protocatechuate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29373", "l": "2'-deoxyadenosine + phosphate => dAMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607733", "l": "BCL10 binds CARD9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14220", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797100", "l": "CCNK binds CDK13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42040", "l": "a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47998", "l": "H2O2 + NAD(+) => 1,6-dihydro-beta-NAD + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43571", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352059", "l": "SLC6A15-mediated amino acid uptake (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54551", "l": "D-xylulose 1,5-bisphosphate + H2O <=> D-xylulose 5-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007539", "l": "CHEK1 phosphorylates E2F6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047874", "l": "dolichyldiphosphatase activity", "d": ["Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10680", "l": "L-proline = D-proline", "d": [], "t": []}, {"i": "EC:5.1.1.4", "l": "\"proline racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25507", "l": "(2E)-geranyl diphosphate <=> beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67232", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168947", "l": "Ligand binds to TLR10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28550", "l": "acetyl-CoA + anthranilate = CoA + N-acetylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944454", "l": "mTORC1 phosphorylates MAF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57854", "l": "2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase => a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610735", "l": "NUMB binds ITCH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159259", "l": "MMAA:MUT binds AdoCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58761", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213201", "l": "Formation of collagen fibres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74303", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43149", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654224", "l": "Activated FGFR3 binds PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944229", "l": "Association of procollagen type IX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34227", "l": "5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.13.11.64", "l": "\"5-nitrosalicylate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39307", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH = (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614544", "l": "Sulfite is oxidized to sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11083", "l": "dTMP + H2O <=> phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034954", "l": "diphenyl ether 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76102", "l": "a dicarboxylate(in) + xanthurenate(out) <=> a dicarboxylate(out) + xanthurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69821", "l": "H2O + NADP(+) + taurine => H(+) + hypotaurine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166817", "l": "Cleavage of C3 by C3 convertases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50740", "l": "H2O + leukotriene C4 = glycine + leukotriene F4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114553", "l": "Activation of conventional Protein Kinase C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381612", "l": "GLP1R binds GLP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139920", "l": "Translocation of tBID to mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41501", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140998", "l": "histone H2B kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H2B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70732", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67175", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] <=> formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55478", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77551", "l": "(9Z)-octadecenoyl-CoA + 3-octadecanoyl-sn-glycerol = 1-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026757", "l": "GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72647", "l": "Cap-bound mRNA is activated by helicases  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36014", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57317", "l": "ATP + cytidine 5'-diphosphoramidate => ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49214", "l": "20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043532", "l": "angiostatin binding", "d": ["Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77481", "l": "(2S)-2-hydroxy-2-methylhexanenitrile => hexan-2-one + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809254", "l": "MTMR8 binds MTMR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735775", "l": "Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25754", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176416", "l": "NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74258", "l": "XDH oxidizes xanthine to form urate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13852", "l": "D-arabinose <=> D-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.5", "l": "\"cucurbitacin Delta(23)-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63807", "l": "GDP-beta-L-gulose <=> GDP-beta-L-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34518", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008456", "l": "alpha-N-acetylgalactosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109862", "l": "MAP2K2 phosphorylates MAPK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31143", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707690", "l": "BACH1 binds MAFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204311", "l": "AOX1 oxidises PXL to PDXate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58086", "l": "(13Z)-docosenoate + glycerol + H(+) => 1-(13Z-docosenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70617", "l": "H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein] => hexadecanoyl-[ACP] + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332363", "l": "Autophosphorylation and activation of CAMK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631941", "l": "SESN1,2,3 bind AMPK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35891", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654514", "l": "KAL1 binds FGFR1c (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004692", "l": "cGMP-dependent protein kinase activity", "d": ["cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28895", "l": "cadaverine(in) + L-lysine(out) = cadaverine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10583", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168885", "l": "Haptoglobin binds Hemoglobin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28935", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52524", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29847", "l": "(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.19", "l": "\"tryptophan dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432010", "l": "Aquaporin-1 passively transports water into cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848338", "l": "PNPLA4 hydrolyzes TAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199456", "l": "PTEN dephosphorylates PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51424", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019531", "l": "oxalate transmembrane transporter activity", "d": ["Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797961", "l": "CHDH oxidises Cho to BETALD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120274", "l": "virus coreceptor activity", "d": ["Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63727", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan O-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41947", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018770", "l": "6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity", "d": ["Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199456", "l": "PTEN dephosphorylates PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903264", "l": "nitrate reductase activity involved in anaerobic electron transport chain", "d": ["Any nitrate reductase activity that is involved in anaerobic electron transport chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53779", "l": "3-sulfanylpropanoate + O2 <=> 3-sulfinopropanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15324", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19763", "l": "FMN + H2O + NAD(+) => FMN-N(5)-oxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49678", "l": "H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(47)-[F-actin] + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156912", "l": "Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019177", "l": "dihydroneopterin triphosphate pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39851", "l": "2 a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004920", "l": "interleukin-10 receptor activity", "d": ["Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614461", "l": "Tetramerization of procollagen VI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41253", "l": "7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015187", "l": "glycine transmembrane transporter activity", "d": ["Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59786", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH => H2O + NADP(+) + pseudopaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043713", "l": "(R)-2-hydroxyisocaproate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031891", "l": "type 1 vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a type 1 vasoactive intestinal polypeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49219", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963851", "l": "VD3 dissociates from GC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875591", "l": "DOCK7 activates RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74775", "l": "kaempferide + S-adenosyl-L-methionine = 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16332", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73732", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate => (2S,3R,11S)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24235", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13788", "l": "(3S)-citramalyl-CoA <=> H2O + itaconyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022911", "l": "CSPG is secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23090", "l": "1-O-alkylglycerone 3-phosphate + ADP + H(+) => ATP + O-alkylglycerone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.7", "l": "\"N-formylmethionyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11376", "l": "(19E)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.36", "l": "\"geissoschizine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35589", "l": "phosphate + riboflavin => FMN + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669023", "l": "TWEAK binds FN14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18957", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.53", "l": "\"(R)-limonene 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419490", "l": "Binding of ATP to P2X receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102109", "l": "tricaffeoyl spermidine O-methyltransferase activity", "d": ["Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine = 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031846", "l": "neurotensin receptor binding", "d": ["Binding to a neurotensin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74344", "l": "O-hexanoyl-(R)-carnitine(in) => O-hexanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23181", "l": "a secondary alcohol + O2 => a ketone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10418", "l": "2-benzylsuccinate => fumarate + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29472", "l": "D-ribose 5-phosphate + H2O => D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.61", "l": "\"tubulin-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66542", "l": "AH2 + cholesta-5,7-dien-3beta,25-diol => 7-dehydrocholesterol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30374", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> (-)-geosmin + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050178", "l": "phenylpyruvate tautomerase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73303", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) = H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10231", "l": "citrate <=> cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696605", "l": "USP12, USP26 deubiquitinate AR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42965", "l": "uridine(54/55) in tRNA => pseudouridine(54/55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52344", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56512", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47623", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 <=> 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176175", "l": "Stalling of DNA replication fork and RPA binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191072", "l": "Synthesis of Cx43 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12207", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097322", "l": "7SK snRNA binding", "d": ["Binding to a 7SK small nuclear RNA (7SK snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65146", "l": "CO2 + H2O + preaustinoid A + succinate => 2-oxoglutarate + berkeleyone A + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.-", "l": "\"Endopeptidases of unknown catalytic mechanism\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874078", "l": "PTK2 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70243", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose = a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47568", "l": "a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38258", "l": "(S)-malate + succinyl-CoA <=> (S)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018814", "l": "RHOT1 hydrolyzes GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186773", "l": "PDGF dimer binds two receptors simultaneously (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36896", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.21", "l": "\"primary-amine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15720", "l": "daunorubicin + H(+) + NADPH + O2 <=> doxorubicin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59040", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29277", "l": "L-isoleucine(out) + Na(+)(out) => L-isoleucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166214", "l": "FA anion flip-flops to the opposite surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038653", "l": "RHCE gene produces Rhesus C or E proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49177", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56064", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.42", "l": "\"UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74401", "l": "2 (S)-lactate(out) + prostaglandin F2alpha(in) => 2 (S)-lactate(in) + prostaglandin F2alpha(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610752", "l": "GLI3R translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55060", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655827", "l": "Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63717", "l": "losartan + UDP-alpha-D-glucuronate => losartan-1-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009309", "l": "RUNX2 binds STUB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70885", "l": "H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in) => H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56307", "l": "ATP + H2O + rifampicin <=> 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31205", "l": "3-oxooctanoyl-CoA + CoA => acetyl-CoA + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73529", "l": "TDP(in) + UTP(out) => TDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16313", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.66", "l": "\"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042017", "l": "interleukin-22 binding", "d": ["Binding to interleukin-22."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24663", "l": "H(+) + L-arginine + NADPH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58725", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25590", "l": "(S)-oxalosuccinate + H(+) + NADPH => D-threo-isocitrate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49831", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27672", "l": "myo-inositol + phosphate => 1D-myo-inositol 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102709", "l": "S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31242", "l": "4 H(+) + uroporphyrinogen I <=> 4 CO2 + coproporphyrinogen I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0070279", "l": "vitamin B6 binding", "d": ["Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38098", "l": "gamma-tocotrienol + S-adenosyl-L-methionine <=> alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033694", "l": "oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.5.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001019", "l": "plastid promoter transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13925", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45914", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69820", "l": "H(+) + hypotaurine + NADPH + O2 => H2O + NADP(+) + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177284", "l": "PKA phosphorylates PDE4B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0042285", "l": "xylosyltransferase activity", "d": ["Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674808", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31514", "l": "chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69227", "l": "a (Z)-alkenyl glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42209", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 => a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687088", "l": "PKA phosphorylates MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623023", "l": "AGRP gene expression is stimulated by FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603784", "l": "PEX19:class I PMP binds PEX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093342", "l": "SDC2 multimerises (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61061", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose => a neolactoside nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047942", "l": "glutamate-ethylamine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878056", "l": "RUNX1:CBFB binds EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47448", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48545", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59571", "l": "4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17954", "l": "3-hydroxyanthranilate + O2 => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37330", "l": "ATP + H2O + L-methionyl-L-alanine(out) <=> ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444523", "l": "CXCR5 binds CXCL13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27496", "l": "S-adenosyl-L-methionine + tricetin <=> 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029473", "l": "Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76031", "l": "2 H2O2 => O2 + 2 H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68960", "l": "DNA polymerase epsilon binds at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018848", "l": "pinocarveol isomerase activity", "d": ["Catalysis of the reaction: pinocarveol = carveol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67608", "l": "H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30410", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] <=> oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54410", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800120", "l": "POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63212", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal = 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76902", "l": "cyclohexylamine + H2O + NADP(+) <=> cyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47105", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O => 5,6,7,8-tetrahydromethanopterin + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51613", "l": "(R)-2-hydroxyglutarate + oxaloacetate => (R)-malate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615668", "l": "AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016737", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.19.-.-", "l": "\"Acting on reduced flavodoxin as donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23693", "l": "(R)-malate => H2O + maleate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114552", "l": "Thrombin-activated PARs activate G12/13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018754", "l": "GDIs bind RHOH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61436", "l": "ADP + H2O = AMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45321", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine => H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37121", "l": "2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016795", "l": "phosphoric triester hydrolase activity", "d": ["Catalysis of the hydrolysis of a phosphoric triester."], "t": []}, {"i": "EC:3.1.8.-", "l": "\"Phosphoric triester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11444", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.9", "l": "\"chondro-4-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620103", "l": "ALDH2 transforms GTN to NO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26095", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4R)-limonene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202307", "l": "Change of PKC theta conformation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693009", "l": "Expression of AMH in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52922", "l": "16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36875", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64798", "l": "(S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+) => H2O + L-lysine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53158", "l": "H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009011", "l": "starch synthase activity", "d": ["Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12850", "l": "H2O + O-phospho-L-seryl-[myosin light chain] => L-seryl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042284", "l": "sphingolipid delta-4 desaturase activity", "d": ["Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.87435383147438", "identifiers": [{"i": "GO:0016645", "l": "oxidoreductase activity, acting on the CH-NH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.5.-.-", "l": "\"Acting on the CH-NH group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31210", "l": "FAD + H(+) + hexanoyl-CoA <=> (2E)-hexenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56308", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.54", "l": "\"1,2-dehydroreticuline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004933", "l": "mating-type a-factor pheromone receptor activity", "d": ["Combining with the mating-type a-factor pheromone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004123", "l": "cystathionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067667", "l": "IL6 binds IL6R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008048", "l": "calcium sensitive guanylate cyclase activator activity", "d": ["Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60890", "l": "(N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25800", "l": "H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9010815", "l": "SLITs bind keratan sulfate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75652", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate => 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31404", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) => all-trans-4,4'-diaponeurosporene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33110", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-muurolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68723", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353323", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63059", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692738", "l": "HRH2 binds HRH2 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22062", "l": "2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46375", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28640", "l": "(2Z,6E)-farnesyl diphosphate => (-)-gamma-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54322", "l": "a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36513", "l": "(11Z)-3-oxoicosenoyl-CoA + CO2 + CoA => (9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54045", "l": "(2E,6E)-farnesyl diphosphate + H2O => 7-epi-alpha-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1006169", "l": "Factor H binds host cell surface markers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25581", "l": "alpha-L-fucose => beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851890", "l": "MET phosphorylates SHC1-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35711", "l": "acetate + succinyl-CoA = acetyl-CoA + succinate", "d": [], "t": []}, {"i": "EC:2.8.3.18", "l": "\"succinyl-CoA:acetate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14516", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine <=> ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31433", "l": "(-)-beta-santalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11576", "l": "ATP + thiamine = AMP + H(+) + thiamine diphosphate", "d": [], "t": []}, {"i": "EC:2.7.6.2", "l": "\"thiamine diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16650", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32254", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34924", "l": "nitrate(in) => nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211983", "l": "CYP2J2 oxidises ARA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617896", "l": "Retinoic acid activates HOXD4 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591052", "l": "PROCR binds Protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71082", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] <=> cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46745", "l": "ATP + hydrogencarbonate => ADP + carboxyphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58351", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34257", "l": "(R)-tetraprenyl-beta-curcumene + H2O => sporulenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41943", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate <=> [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606392", "l": "Lewis antigens translocate from Golgi lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51054", "l": "5alpha-androst-1-ene-3,17-dione + AH2 => 5alpha-androstan-3,17-dione + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050534", "l": "3-deoxyoctulosonase activity", "d": ["Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005127", "l": "ciliary neurotrophic factor receptor binding", "d": ["Binding to a ciliary neurotrophic factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52430", "l": "12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+) => 12-oxo-leukotriene B4 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381091", "l": "IRE1 dimer autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39675", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008977", "l": "prephenate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41225", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682011", "l": "LC3 binds ATG7 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11170", "l": "3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH => 3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444516", "l": "Formation of MSH2:MSH6 Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047480", "l": "UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54601", "l": "2-oxoglutarate + O2 + octanoyl-CoA => 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374298", "l": "Opioid receptors bind opioid peptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204873", "l": "Interaction of Tie2 and Shp2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805811", "l": "Release of SEPT4 from mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467466", "l": "ABCA4 mediates atRAL transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033443", "l": "AAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64287", "l": "2-phenylethylamine + pyruvate <=> 2-phenylacetaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003680", "l": "minor groove of adenine-thymine-rich DNA binding", "d": ["Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0016848", "l": "carbon-halide lyase activity", "d": ["Catalysis of the breakage of a bond between carbon and any halogen atom."], "t": []}, {"i": "EC:4.5.-.-", "l": "\"Carbon-halide lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77353", "l": "(2S)-2-aminobutanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate => 2-oxobutanoate + N(omega),N(omega)-dimethyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784434", "l": "An unknown carrier transports cytosolic glyoxylate to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47207", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27330", "l": "H(+) + NADH + O2 + urate => 5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66999", "l": "2-methylpentanoate + ATP + CoA <=> 2-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50122", "l": "CoA + H(+) + N-tetracosanoyl-taurine => taurine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35070", "l": "(S)-carnitine(out) <=> (S)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018064", "l": "protein-L-histidine N-tele-methyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295599", "l": "SPRY2 translocates to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52836", "l": "H(+) + indole + NADH + O2 = H2O + indoxyl + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607023", "l": "factor IXa associates with cell membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59393", "l": "acetyl-CoA + L-seryl-[protein] => CoA + O-acetyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72980", "l": "didemethylasterriquinone D + dimethylallyl diphosphate => asterriquinone C1 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371353", "l": "Soluble TNF-α binds TNFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55197", "l": "2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26491", "l": "a secondary nitroalkane + H2O + O2 => a ketone + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218821", "l": "PDK1 phosphorylates PKC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65675", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77346", "l": "N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54908", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (4E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40756", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036132", "l": "13-prostaglandin reductase activity", "d": ["Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948136", "l": "ULK1 Translocates to the mitochondria (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75789", "l": "GTP(out) => GTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690873", "l": "ACO1 binds 4Fe-4S (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43715", "l": "ATP + dodecanoate + H(+) <=> diphosphate + dodecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428885", "l": "Activation of CLASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40284", "l": "(R)-carnitine + hexadecanedioyl-CoA => CoA + O-hexadecanedioyl-L-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11096", "l": "NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63543", "l": "H2O + neurotensin <=> L-leucine + neurotensin-(1-12)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211948", "l": "CYP3A4 can N-demethylate loperamide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32404", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42264", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA = 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.207", "l": "\"beta-ketodecanoyl-[acyl-carrier-protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24239", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14444", "l": "acetyl-CoA + gentamicin C <=> CoA + H(+) + N(3)-acetylgentamycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901974", "l": "glycerate transmembrane transporter activity", "d": ["Enables the transfer of glycerate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004050", "l": "apyrase activity", "d": ["Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9658253", "l": "RAS:GTP binds PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12882", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706304", "l": "Active FLT3 binds to GRAP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57605", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73928", "l": "griseophenone D + S-adenosyl-L-methionine => griseophenone C + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30804", "l": "4-aminobutanal + H2O + NADP(+) => 4-aminobutanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39569", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65429", "l": "deamido-NAD(+)(in) + NAD(+)(out) => deamido-NAD(+)(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62551", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56968", "l": "dCTP + pyruvate = dCDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32650", "l": "erythromycin C + S-adenosyl-L-methionine <=> erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446364", "l": "Migfilin interacts with VASP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38650", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15583", "l": "biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA => biochanin A 7-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332356", "l": "CAMK2 binds MAP3K7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47096", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.86", "l": "\"trans,polycis-decaprenyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22457", "l": "creatine + H2O => sarcosine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352059", "l": "SLC6A15-mediated amino acid uptake (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45433", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341294", "l": "Superoxide reduces cytochrome c (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947541", "l": "Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67990", "l": "N-acetyl-D-glutamine => N-acetyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68737", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] => ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730841", "l": "Phosphorylation and activation of VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080049", "l": "L-gulono-1,4-lactone dehydrogenase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050525", "l": "cutinase activity", "d": ["Catalysis of the reaction: cutin + H2O = cutin monomers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703435", "l": "FLT3 fusions activate STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047844", "l": "deoxycytidine deaminase activity", "d": ["Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430135", "l": "p-SLP-76 binds ADAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30692", "l": "H2O2 + methanol => formaldehyde + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58653", "l": "rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28292", "l": "(5S,9S,10S)-drim-7-en-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209823", "l": "Tyrosine is hydroxylated to dopa (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080062", "l": "cytokinin 9-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event."], "t": []}, {"i": "KEGG.REACTION:R08369", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74428", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61239", "l": "H2O + L-methionine + O2 <=> 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28508", "l": "4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352268", "l": "Cleavage of Satb1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944223", "l": "Association of procollagen type V (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60291", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27920", "l": "2 H(+) + NADPH + propanoate => H2O + NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48716", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73883", "l": "guanidine(out) = guanidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20423", "l": "D-glucose + D-glucose 6-phosphate => alpha-maltose 6'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033948", "l": "fructan beta-(2,1)-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21451", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] <=> 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49459", "l": "(2S)-2-amino-4-deoxychorismate + H2O <=> (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814555", "l": "Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17612", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0005030", "l": "neurotrophin receptor activity", "d": ["Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53229", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65984", "l": "hnu + previtamin D3 = lumisterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55752", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.8.98.6", "l": "\"formate:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29257", "l": "Ca(2+)(out) + Na(+)(in) => Ca(2+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035715", "l": "chemokine (C-C motif) ligand 2 binding", "d": ["Binding to chemokine (C-C motif) ligand 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024624", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27559", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.83", "l": "\"hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0016040", "l": "glutamate synthase (NADH) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66314", "l": "a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+) => an alpha-mannosylinositol-1-phosphoceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41607", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656070", "l": "FGFBPs bind FGFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66611", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O <=> GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983424", "l": "Budding of COPII coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48794", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33943", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44668", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.47", "l": "\"teichoic acid ribitol-phosphate polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41489", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353318", "l": "Insertion of correct bases opposite to the lesion by Pol kappa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22702", "l": "gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76989", "l": "an N-acylsphing-4-enine(out) => an N-acylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22142", "l": "a nucleoside + phosphate => a nucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665989", "l": "DIAPH1 binds RHOA:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44526", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70023", "l": "4-hydroxy-L-proline(in) + Na(+)(in) = 4-hydroxy-L-proline(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72024", "l": "nicotinate(in) + urate(out) => nicotinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964274", "l": "G alpha (12) binds BTK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213207", "l": "Formation of collagen networks (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53819", "l": "hydrogen sulfide + O-succinyl-L-serine <=> L-cysteine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68805", "l": "H2O + kojibiose => alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649733", "l": "mature p21 RAS binds GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68698", "l": "17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796080", "l": "AcK-NFE2L2 binds the NFE2L2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730856", "l": "Autophosphorylation of PAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64464", "l": "L-tyrosyl-[protein] + 2 O2 = H(+) + H2O2 + L-topaquinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696356", "l": "OSCAR binds collagen and SP-D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52618", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090489", "l": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)", "d": ["Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977363", "l": "Factor H binds to C3bBb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66723", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) <=> ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32726", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40003", "l": "ent-copalyl diphosphate = (Z)-biformene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45296", "l": "a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76987", "l": "an N-acylsphing-4-enine(in) = an N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56406", "l": "(3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18120", "l": "L-tyrosine + O2 <=> H2O + L-dopaquinone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11429", "l": "beta-D-glucose + O2 => D-glucono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209738", "l": "VD3 binds GC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15647", "l": "16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102995", "l": "angelicin synthase activity", "d": ["Catalysis of the reaction: columbianetin + NADPH + O2 + H+ = angelicin + acetone + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706315", "l": "Active FLT3 binds to SH2B3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33607", "l": "(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25010", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62888", "l": "GDP-beta-L-fucose + lactose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41677", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928641", "l": "PAK binds RAC and bPIX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102473", "l": "eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose = 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156682", "l": "PLK1 phosphorylates NUDC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25984", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400204", "l": "PPARA binds RXRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57800", "l": "2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67892", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine = 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696356", "l": "OSCAR binds collagen and SP-D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62186", "l": "diphosphate + labd-13(16),14-diene-9-ol => peregrinol diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35239", "l": "tetracycline(in) = tetracycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362549", "l": "Hh-Np traffics to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49028", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.131", "l": "\"bursehernin 5'-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70279", "l": "H2O + stachyose = D-galactose + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205649", "l": "p62 links damaged mitochondria to LC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786190", "l": "CMBL hydrolyses OM to OLMS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50531", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29958", "l": "H(+)(in) + thymidine(in) <=> H(+)(out) + thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58256", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74753", "l": "holo-[polyketide synthase] + prefumagillin => dodecapentaneoyl-[polyketide synthase] + fumagillol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36254", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17622", "l": "acetyl-CoA + citramalate => (3S)-citramalyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851979", "l": "BTNL9 binds immune cell surfaces (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634861", "l": "NPAS4 binds ARNT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47196", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12123", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) <=> ADP-alpha-D-glucose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46933", "l": "2-epi-5-epi-valiolone 7-phosphate => 5-epi-valiolone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55565", "l": "4-hydroxytryptamine + ATP => 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12604", "l": "2-oxoglutarate + L-2-aminoadipate <=> 2-oxoadipate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65713", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404134", "l": "RBP4:atROL binds TTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13663", "l": "N-formyl-L-aspartate + NH4(+) => H2O + N-formimidoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179410", "l": "Association of Nek2A with MCC:APC/C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950362", "l": "EBI3:CANX binds IL12A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047426", "l": "ricinine nitrilase activity", "d": ["Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447246", "l": "IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667456", "l": "AVPR1A,B bind desmopressin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21525", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O => (2S)-2-isopropylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57087", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17665", "l": "L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.3.1.181", "l": "\"lipoyl(octanoyl) transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45446", "l": "H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42071", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH <=> clavulanate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52875", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35630", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21207", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37226", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52337", "l": "a long-chain fatty acid + ATP + H(+) => a long-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50782", "l": "(2E)-octenal + H(+) + NADPH => NADP(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46119", "l": "2-dehydro-3-deoxy-D-galactonate <=> D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.2", "l": "\"pectate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25157", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33125", "l": "(R)-tetraprenyl-beta-curcumene + diphosphate => all-trans-heptaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017067", "l": "tyrosine-ester sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160150", "l": "tRNA pseudouridine(13) synthase activity", "d": ["Catalysis of the reaction: uridine(13) in tRNA = pseudouridine(13) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52190", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => 1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31544", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose => 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856808", "l": "Recruitment of AP-2 complex and clathrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109701", "l": "PDPK1 binds PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156682", "l": "PLK1 phosphorylates NUDC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64058", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2R)-ephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58116", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.376", "l": "\"EGF-domain serine glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018483", "l": "6-oxohexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69138", "l": "2 H2O2 + 2 NH4(+) + spermine dialdehyde => 2 H2O + 2 O2 + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16117", "l": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.16", "l": "\"acetoacetate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45901", "l": "a (3Z)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18096", "l": "5,6-dihydrouracil + NADP(+) <=> H(+) + NADPH + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18799", "l": "a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55055", "l": "H2O + pentanoyl-CoA <=> CoA + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102718", "l": "TRIBOA-glucoside methyltransferase activity", "d": ["Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine = (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794475", "l": "Cipro:ALB dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25306", "l": "7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592362", "l": "Activation of proMMP7 by MMP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14721", "l": "UDP-alpha-D-xylose + zeatin = H(+) + O-beta-D-xylosylzeatin + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.40", "l": "\"zeatin O-beta-D-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707856", "l": "PGRMC2:Hemes dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46676", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) = (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203774", "l": "Interaction of Csk with PAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21834", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59747", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58216", "l": "A + dihydroserpentine = AH2 + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48574", "l": "(2E,4E)-2,4-dichloromuconate + 2 H(+) => 3,5-dichlorocatechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0019111", "l": "phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43609", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O => 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163625", "l": "Glucagon binds to Glucagon receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75277", "l": "(10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32202", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727349", "l": "XDH dehydrogenates xanthine to form urate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45848", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) = 3-oxododecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77664", "l": "1-O-alkyl-3-acylglycerol + an acyl-CoA => 1-O-alkyl-2,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046405", "l": "glycerol dehydratase activity", "d": ["Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836606", "l": "SPHK1 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433592", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.-.-", "l": "\"Acting on the aldehyde or oxo group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9842656", "l": "ALK binds ALKAL ligand (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48489", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) => all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74723", "l": "Endosome acidification (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23788", "l": "acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.22", "l": "\"[citrate (pro-3S)-lyase] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73981", "l": "calarene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27770", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210439", "l": "glutamate uptake by astrocytes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77397", "l": "(2S)-2-hydroxybutanenitrile => hydrogen cyanide + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72938", "l": "(S)-lactate(out) + 2 Na(+)(out) <=> (S)-lactate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65837", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40935", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450494", "l": "HuR binds mRNAs in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71920", "l": "3 Na(+)(out) + succinate(out) => 3 Na(+)(in) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42118", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65577", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate => an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77068", "l": "Activation of GT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030408", "l": "glycine formimidoyltransferase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635859", "l": "GLI:SUFU dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050153", "l": "omega-hydroxydecanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25996", "l": "H2O + N(1)-acetylspermine + O2 = H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35679", "l": "dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23725", "l": "H2O + O2 + pyridoxal => 4-pyridoxate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77077", "l": "2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (1R,4R,5S)-acoradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49279", "l": "CTP + phytyl phosphate <=> CDP + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950504", "l": "IL27 binds CRLF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097372", "l": "NAD-dependent histone H3K18 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395340", "l": "Formation of hydroxyallysine by LOX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70727", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O = 6-sulfo-alpha-D-quinovose + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37638", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008775", "l": "acetate CoA-transferase activity", "d": ["Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24025", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173705", "l": "C5b binds C6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008939", "l": "nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23237", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O => H(+) + L-glutamyl-[protein] + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392870", "l": "Gs activation by prostacyclin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25347", "l": "D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44421", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018766", "l": "RHOU binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0047850", "l": "diaminopimelate dehydrogenase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + H2O + NADP+ = L-2-amino-6-oxopimelate + H+ + NADPH + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990624", "l": "guanyl nucleotide exchange factor inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17964", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> H2O + leukotriene A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65037", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45142", "l": "CO2 + L-glutamyl-[protein] + O2 + phylloquinol => 2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852362", "l": "GTSE1 binds CDKN1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30998", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004706", "l": "JUN kinase kinase kinase activity", "d": ["Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31224", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O => beta-D-glucose + cis-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694409", "l": "Nucleotide exchange on RAB1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67420", "l": "a glycerophospholipid + H2O = a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50722", "l": "FMN + H(+) + H2O + methanesulfonate => FMNH2 + methanesulfinate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62686", "l": "H(+) + rubrofusarin + S-adenosyl-L-homocysteine => norrubrofusarin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654425", "l": "Activated FGFR4 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031847", "l": "type 1 neurotensin receptor binding", "d": ["Binding to a type 1 neurotensin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16318", "l": "(S)-indan-1-ol + NAD(+) => H(+) + indan-1-one + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47935", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53065", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate => 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69988", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) => (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010472", "l": "GDP-galactose:glucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-glucose 1-phosphate = beta-L-galactose-1-phosphate + GDP-alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031755", "l": "Edg-2 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-2 lysophosphatidic acid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390593", "l": "ATP Hydrolysis By Myosin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052660", "l": "R-lactaldehyde reductase activity", "d": ["Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390929", "l": "HTR1 and 5A receptors can bind serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937792", "l": "RUNX3 binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56951", "l": "pyruvate + UTP <=> H(+) + phosphoenolpyruvate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004934", "l": "mating-type alpha-factor pheromone receptor activity", "d": ["Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34130", "l": "(2E)-geranyl diphosphate + olivetolate <=> cannabigerolate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57080", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": [], "t": []}, {"i": "EC:2.8.4.6", "l": "\"S-methyl-1-thioxylulose 5-phosphate methylthiotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429694", "l": "CERT1-2 complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40884", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29353", "l": "Zn(2+)(out) => Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030293", "l": "transmembrane receptor protein tyrosine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56002", "l": "beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183126", "l": "Factor B binds to surface-associated C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014296", "l": "RAC2 GEFs activate RAC2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0034072", "l": "squalene cyclase activity", "d": ["Catalysis of the reaction: squalene = triterpene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49883", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40161", "l": "NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684006", "l": "KPNA2 translocates NBN to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17136", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] <=> ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831152", "l": "SH pentamer localizes to host cell plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220976", "l": "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55802", "l": "an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018754", "l": "GDIs bind RHOH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46062", "l": "(5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44363", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48951", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004803", "l": "transposase activity", "d": ["Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250280", "l": "ROS oxidize thioredoxin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070012", "l": "oligopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53375", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) <=> H(+) + NADH + uridine(17) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963913", "l": "1,25(OH)2D translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417890", "l": "P2Y5 receptor can bind to LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62261", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) => 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41725", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53196", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69187", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451366", "l": "Activation of p38MAPK by DSCAM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977363", "l": "Factor H binds to C3bBb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112514", "l": "JAK activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12613", "l": "2 glutathione + L-cystine = glutathione disulfide + 2 L-cysteine", "d": [], "t": []}, {"i": "EC:1.8.4.4", "l": "\"glutathione--cystine transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193981", "l": "CYP21A2 oxidises 17HPROG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419049", "l": "ROCK activation by RHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76351", "l": "oxaloacetate(in) + sulfate(out) = oxaloacetate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15492", "l": "adenosine + H2O + 2 O2 <=> 9-riburonosyladenine + H(+) + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332236", "l": "CBL neddylates TGFBR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797974", "l": "LRRTMs bind NRXNs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34576", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006325", "l": "EPO binds EPOR:JAK2:LYN:IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37451", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001854", "l": "complement component C3d binding", "d": ["Binding to a C3d product of the complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681375", "l": "KIT binds ripretinib (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40767", "l": "(20S)-ginsenoside R1 + H2O = (20S)-ginsenoside Rg1 + D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050484", "l": "GMP 5'-nucleotidase activity", "d": ["Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10075", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine <=> glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64962", "l": "dTMP + H(+) + phosphate => dTDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75842", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) <=> H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36266", "l": "hydroxyurea + O-acetyl-L-serine <=> acetate + H(+) + O-ureido-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18933", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.107", "l": "\"3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59920", "l": "(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61133", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + kaempferol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371518", "l": "SIRT1 binds to HSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36772", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950732", "l": "Expression of Macrophage migration inhibitory factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42884", "l": "(R)-mevalonate + ATP = (R)-3-phosphomevalonate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.185", "l": "\"mevalonate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509838", "l": "ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660665", "l": "Caspase-8 binds MALT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685156", "l": "ATR phosphorylates RPA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69361", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] => 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004798", "l": "thymidylate kinase activity", "d": ["Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68225", "l": "2-oxoglutarate + H(+) + O2 + prekainate => CO2 + H2O + kainate lactone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855232", "l": "RELN:VLDLR binds DAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38528", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35175", "l": "novobiocin(in) = novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53478", "l": "(6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36690", "l": "hexadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191763", "l": "snRNP:Snurportin complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23279", "l": "2-dehydropantoate <=> 3-methyl-2-oxobutanoate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382054", "l": "PDGF binds to extracellular matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15652", "l": "carbamate + 2 H(+) <=> CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226979", "l": "ADD1:ADD2 binds DMTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49924", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37307", "l": "glycyl-L-asparagine + H2O = glycine + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33972", "l": "5''-phosphoribostamycin + H2O => phosphate + ribostamycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50509", "l": "acetyl-CoA + N-terminal L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46713", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030352", "l": "inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15565", "l": "an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37306", "l": "ATP + glycyl-L-asparagine(out) + H2O <=> ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28089", "l": "2 H2O2 + Reactive Blue 5 <=> 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818577", "l": "TASP1 cleaves KMT2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862300", "l": "LYZ binds bacterial peptidoglycan (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804100", "l": "HMGB1 binds LPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047269", "l": "poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16731", "l": "catechol + H(+) + NADPH => (1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28981", "l": "H(+)(in) + nitrite(out) => H(+)(out) + nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030196", "l": "cyanide hydratase activity", "d": ["Catalysis of the reaction: formamide = H2O + hydrogen cyanide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004381", "l": "fucosylgalactoside 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33322", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088130", "l": "PLK1 binds FOXM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22997", "l": "H2O2 + L-ascorbate => 2 H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15773", "l": "ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.29", "l": "\"glycerone kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37164", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193097", "l": "Pregnenolone translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21019", "l": "H2O + L-asparagine <=> L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16685", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA = a dolichyl hexadecanoate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.123", "l": "\"dolichol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "51.119841238951558", "identifiers": [{"i": "GO:0005515", "l": "protein binding", "d": ["Binding to a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13519", "l": "ADP + dTDP => ATP + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35848", "l": "ATP + sphing-4-enine => ADP + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57766", "l": "3-methyl-4-nitrocatechol + NAD(+) + nitrite => 2,6-dinitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39485", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59544", "l": "N,N'-diacetylchitobiose + O2 = H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27985", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) <=> 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21152", "l": "trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline", "d": [], "t": []}, {"i": "EC:5.1.1.8", "l": "\"4-hydroxyproline epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62439", "l": "L-lyxonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68622", "l": "20beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56247", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63973", "l": "A + dihydropyriculol => AH2 + pyriculol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71251", "l": "L-xylopyranose = L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17010", "l": "2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013158", "l": "CDC42 GDIs block activation of CDC42 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62080", "l": "D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036319", "l": "mating-type M-factor pheromone receptor activity", "d": ["Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50707", "l": "1-propanol + NAD(+) <=> H(+) + NADH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218804", "l": "p38 MAPK activation by VEGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62330", "l": "(+)-malbrancheamide + FADH2 => (+)-isomalbrancheamide B + chloride + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51655", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029471", "l": "Hydrolysis of PC to PA by PLD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944233", "l": "Association of procollagen type XIX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22943", "l": "ATP + L-arginine <=> ADP + H(+) + N(omega)-phospho-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45359", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine <=> (11Z)-eicosenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45484", "l": "H(+) + pyruvate = acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53241", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018645", "l": "alkene monooxygenase activity", "d": ["Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74134", "l": "malvidin + UDP-alpha-D-galactose <=> H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43218", "l": "(24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17801", "l": "acetyl-CoA + L-phenylalanine = CoA + H(+) + N-acetyl-L-phenylalanine", "d": [], "t": []}, {"i": "EC:2.3.1.53", "l": "\"phenylalanine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16710", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050420", "l": "maltose synthase activity", "d": ["Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28796", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191402", "l": "Reduction of presqualene diphosphate to form squalene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10061", "l": "acetyl-CoA + D-tryptophan => CoA + H(+) + N-acetyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341048", "l": "SUMOylation of RXRA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77296", "l": "a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate => a ganglioside GT3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38565", "l": "1-O-hexadecyl-sn-glycerol + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69956", "l": "Ca(2+)(in) + 3 Na(+)(out) => Ca(2+)(out) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952996", "l": "E2F7 forms homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928640", "l": "PAKs phosphorylate MLC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62858", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68893", "l": "3-methoxybenzoate + ATP + H(+) + NADPH => 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.39", "l": "\"adenain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67106", "l": "CO2 + H2O + novofumigatonin + succinate => 2-oxoglutarate + fumigatonoid C + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43124", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.213", "l": "\"tRNA (guanine(10)-N(2))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675790", "l": "MTORC1 dissociates from ULK complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59792", "l": "H2O + NADP(+) + yersinopine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046848", "l": "hydroxyapatite binding", "d": ["Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018522", "l": "benzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H2O + benzoyl-CoA + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202724", "l": "P-selectin binds P-selectin ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57300", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62975", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33557", "l": "(4R)-hydroxysphinganine + a fatty acid => an N-acyl-(4R)-4-hydroxysphinganine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033852", "l": "thyroid-hormone transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75830", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202717", "l": "Heterodimerization of CEACAMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806974", "l": "MET dimers autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070097", "l": "delta-catenin binding", "d": ["Binding to the delta subunit of the catenin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37615", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433506", "l": "Phosphorylation of APS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814094", "l": "ARL1:GTP binds ARFIP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029690", "l": "Caspase-6 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65332", "l": "H(+) + NADPH + O2 + verruculide A = chrodrimanin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38559", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate = (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44480", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52054", "l": "9-hydroxy-octadecanoate + H(+) + hexadecanoate => 9-hexadecanoyloxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047596", "l": "6-methylsalicylate decarboxylase activity", "d": ["Catalysis of the reaction: 6-methylsalicylate + H+ = 3-cresol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004592", "l": "pantoate-beta-alanine ligase activity", "d": ["Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0003918", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75033", "l": "(9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47301", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944227", "l": "Association of procollagen type XXII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612219", "l": "ERBB4s80 binds to SRC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18013", "l": "H2O + N(5)-ethyl-L-glutamine = ethylamine + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.65", "l": "\"theanine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003977", "l": "UDP-N-acetylglucosamine diphosphorylase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20952", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.188", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981648", "l": "C4b binding protein binds C4bC2a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391939", "l": "TP receptor can bind thromboxane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849906", "l": "SALM1 binds NMDA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428752", "l": "Dissociation of the TP:Gq complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102749", "l": "dihydrogeranylgeranyl-chlorophyll a reductase activity", "d": ["Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75994", "l": "a dicarboxylate(in) + N-benzoylglycine(out) <=> a dicarboxylate(out) + N-benzoylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.136", "l": "\"gallate 1-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69292", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = goitrin + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392195", "l": "Gi activation by P2Y purinoceptor 12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67141", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 => H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090589", "l": "protein-phosphocysteine-trehalose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426223", "l": "Cation influx mediated by TRPC3/6/7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53712", "l": "2 Fe(III)-heme b = beta-hematin", "d": [], "t": []}, {"i": "EC:4.99.1.8", "l": "\"heme ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793122", "l": "MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37573", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912627", "l": "CBL ubiquitinates PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062076", "l": "acyl-CoA delta5-desaturase activity", "d": ["Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27732", "l": "beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50789", "l": "NADP(+) + pentan-2-one => (E)-pent-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29620", "l": "alpha-maltotetraose + beta-maltose => alpha-maltopentaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42210", "l": "a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+) => a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73351", "l": "ATP + beta-alanine + histamine = AMP + carcinine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381091", "l": "IRE1 dimer autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835358", "l": "p-TARBP2 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248002", "l": "Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046981", "l": "beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25363", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) = H(+) + momilactone A + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757578", "l": "ALB binds PREDN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350444", "l": "ROK phosphorylates SQH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33172", "l": "D-maltose(in) => D-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33637", "l": "AMP + diphosphate + docosanoyl-CoA => ATP + CoA + docosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74530", "l": "H(+) + N(6),N(6)-dimethyl-L-lysine <=> CO2 + N,N-dimethyl-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195275", "l": "Phosphorylation of APC component of the destruction complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66815", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH <=> 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73088", "l": "AMP(out) + FAD(in) => AMP(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13268", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine <=> 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33879", "l": "2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64008", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008869", "l": "galactonate dehydratase activity", "d": ["Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67561", "l": "3'-phosphoadenylyl sulfate + taurocholate => adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591052", "l": "PROCR binds Protein C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11528", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234084", "l": "SUMOylation of TFAP2B with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202489", "l": "Oligomerization of Bcl10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024967", "l": "BDNF-bound NTRK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52992", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine = [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66093", "l": "3-phenylpyruvate + L-kynurenine => H2O + kynurenate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23336", "l": "2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47932", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) = (2S)-3-sulfolactate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21994", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[histone] => acetyl-CoA + L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.147", "l": "\"thioglucosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11104", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine = H(+) + hercynine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160016", "l": "CCACCA tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: an unstable tRNA + 2 ATP + 4 CTP = a tRNA with a 3' CCACCA end + 6 diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.27", "l": "\"cyclopenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029454", "l": "Autophosphorylation of PAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35269", "l": "ethanol(out) => ethanol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140696", "l": "factor V -> factor Va + factor V activation peptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.74", "l": "\"venombin A\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693001", "l": "NAT8,8B acetylate BACE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419003", "l": "Interaction of Nectins with Afadin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56380", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.56", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66725", "l": "(S)-lactate + L-phenylalanine => H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52333", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] => 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47417", "l": "an NDP-alpha-D-glucose + D-glucose => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855375", "l": "PTPN22 dissociates from CSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209109", "l": "E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50403", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA <=> CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.63", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75748", "l": "10-oxooctadecanoate + H(+) + NADH => 10-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53410", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77434", "l": "a ganglioside GT2 + UDP-alpha-D-galactose <=> a ganglioside GT1c + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30113", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-enterobactin + H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55762", "l": "an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP] => a fatty acyl-[ACP] + a lyso-ornithine lipid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912415", "l": "NOTCH3 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76898", "l": "2-hexyl-5-pentylresorcinol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hexyl-5-(5-hydroxypentyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000102", "l": "L-methionine secondary active transmembrane transporter activity", "d": ["Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31450", "l": "6-amino-2-oxohexanoate + H2O2 <=> 5-aminopentanoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75504", "l": "glycocholate(out) + n H(+)(out) => glycocholate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59540", "l": "(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64653", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190686", "l": "Transport of connexins to the Trans-Golgi Network (TGN) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050480", "l": "imidazolonepropionase activity", "d": ["Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799761", "l": "TP53 binds PPP1R13L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29383", "l": "dIMP + H2O = 2'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64177", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan => (9Z)-octadecenoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34413", "l": "cannabidiolate + H2O2 => cannabigerolate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40915", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9022314", "l": "HIPK2 phosphorylates MECP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68978", "l": "7-oxoglycolithocholate + H(+) + NADPH => glycoursodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174808", "l": "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1017228", "l": "Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39553", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878186", "l": "CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59738", "l": "CoA + S-tetradecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30146", "l": "H2O + octanoyl-CoA <=> CoA + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41715", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41806", "l": "(3R)-hydroxybutanoyl-[ACP] + NADP(+) => 3-oxobutanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981353", "l": "RASA1 stimulates RAS GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66089", "l": "L-kynurenine + oxaloacetate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43287", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070653", "l": "high-density lipoprotein particle receptor binding", "d": ["Binding to a high-density lipoprotein receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43779", "l": "an N-(acyl)-sphingosylphosphocholine(in) <=> an N-(acyl)-sphingosylphosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690701", "l": "SHP1 binds p-CD22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003980", "l": "UDP-glucose:glycoprotein glucosyltransferase activity", "d": ["Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38422", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65404", "l": "butan-1-ol + hexanoyl-CoA = butyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38152", "l": "carbonyl sulfide + H2O => CO2 + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692764", "l": "MAPK6 binds CCND3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71315", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) = chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58199", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] <=> acetate + L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008315", "l": "TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944223", "l": "Association of procollagen type V (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19354", "l": "glycocholate + H2O => cholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47957", "l": "3-maleylpyruvate + H2O => H(+) + maleate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13468", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA <=> CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37199", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12535", "l": "coenzyme B + methyl-coenzyme M <=> coenzyme M-coenzyme B heterodisulfide + methane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190829", "l": "Lysosomal degradation of gap junction plaques (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24919", "l": "L-homoserine = 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106238", "l": "peregrinol diphosphate synthase activity", "d": ["Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24259", "l": "ATP + kanamycin A <=> ADP + H(+) + kanamycin 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730899", "l": "Oligomerization of BCL10 and MALT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001000", "l": "bacterial-type RNA polymerase core enzyme binding", "d": ["Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047812", "l": "D-amino-acid N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34861", "l": "3-oxocyclopentanecarboxylate + NH4(+) => 3-oxocyclopentanecarbonitrile + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27829", "l": "hydrogen sulfide + O-succinyl-L-homoserine <=> L-homocysteine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68675", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46338", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => 3-oxochola-4,17-dien-22-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67354", "l": "6-O-malonyl-rhaponticin + CoA => malonyl-CoA + rhaponticin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632677", "l": "PTCH is internalized (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58487", "l": "H2O + N-(acetyl)-sphing-4-enine <=> acetate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164522", "l": "Terminal (3' end) cleavage of viral DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15963", "l": "H(+) + taxiphyllin + UDP => 4-hydroxymandelonitrile + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932033", "l": "KCTD6 gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35830", "l": "H2O + N(1)-aminopropylagmatine <=> spermidine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20739", "l": "acetyl-CoA + glycine <=> (2S)-2-amino-3-oxobutanoate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74030", "l": "L-alanine(in) + L-threonine(out) <=> L-alanine(out) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67288", "l": "ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine = (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70457", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2 => (6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470010", "l": "Dimerization of STATs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389756", "l": "AKT interacts and phosphorylates Cot (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193653", "l": "NGF homodimer binds to p75NTR (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23816", "l": "2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20540", "l": "H2O + holo-[ACP] <=> (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73531", "l": "CTP(out) + UTP(in) = CTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73797", "l": "FAICAR => IMP + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39180", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH => eicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24195", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77356", "l": "2-oxobutanoate + L-alanine => (2S)-2-aminobutanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19314", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12940", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.78", "l": "\"(R)-3-[(carboxymethyl)amino]fatty acid dioxygenase/decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35894", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45153", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-oxopropanoyl-CoA + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55082", "l": "ADP + H(+) + sucrose => ADP-alpha-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706364", "l": "Internalization of ubiquitinated FLT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13117", "l": "O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}, {"i": "EC:2.5.1.51", "l": "\"beta-pyrazolylalanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204850", "l": "Interaction of Tie2 and Dok-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45249", "l": "butanoate(out) => butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51007", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] <=> an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0001791", "l": "IgM binding", "d": ["Binding to an immunoglobulin of the IgM isotype."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46947", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) <=> H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010179", "l": "IAA-Ala conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166542", "l": "beta-NGF dimer binds to TrkA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76681", "l": "H(+) + NADH + sulfoacetyl-CoA => CoA + NAD(+) + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36001", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749197", "l": "ORC1 binds to H4K20me2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62397", "l": "(1S,2S)-pseudoephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031896", "l": "PD1n-3, PD2n-3 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.26", "l": "\"adenosylcobinamide-GDP ribazoletransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61598", "l": "[DsbD protein]-disulfide + [thioredoxin]-dithiol => [DsbD protein]-dithiol + [thioredoxin]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840401", "l": "DELE1(143-515) is released into the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "47.053343783139773", "identifiers": [{"i": "GO:0022836", "l": "gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419645", "l": "Dimerization of LIMK1 by Hsp90 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44975", "l": "(R)-carnitine + hexanoyl-CoA <=> CoA + O-hexanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432647", "l": "Phosphorylated PER binds to TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932076", "l": "AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59007", "l": "dodecanal + H2O + O2 <=> dodecanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34900", "l": "malonyl-CoA + S-adenosyl-L-methionine => malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987214", "l": "p-STAT3 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65183", "l": "AH2 + O2 + protoaustinoid B <=> A + H2O + preaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11732", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B = H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.142", "l": "\"8-dimethylallylnaringenin 2'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686338", "l": "SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9840564", "l": "OMA1 hydrolyzes YME1L1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.54", "l": "\"methylenetetrahydrofolate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43073", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417890", "l": "P2Y5 receptor can bind to LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012835", "l": "GDIs block activation of RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31368", "l": "2 H(+) + 3 nitrite => H2O + nitrate + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72450", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) <=> a dicarboxylate(out) + estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022872", "l": "protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938773", "l": "RNF144A polyubiquitinates PRKDC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72394", "l": "2 hydrogencarbonate(out) + oxalate(in) <=> 2 hydrogencarbonate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20027", "l": "gibberellin A3 O-beta-D-glucoside + H(+) + UDP => gibberellin A3 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43535", "l": "a ribonucleoside 3',5'-bisphosphate + H2O <=> a ribonucleoside 5'-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003999", "l": "adenine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62880", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 = (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56476", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48848", "l": "(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106614", "l": "Duplex miRNA is loaded into Argonaute (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.-", "l": "\"Transferring other nitrogenous groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73103", "l": "diosmetin + S-adenosyl-L-methionine = luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52231", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46698", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine => a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11012", "l": "H2O + L-tryptophanamide = L-tryptophan + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.57", "l": "\"tryptophanamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701147", "l": "TRPV1 binds TRPV1 blockers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15081", "l": "acetate + ATP + CoA = acetyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12404", "l": "D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.22", "l": "\"lactose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38987", "l": "nonanoyl-CoA + O2 = (2E)-nonenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42357", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72162", "l": "glutarate(in) + taurocholate(out) <=> glutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58498", "l": "glycolaldehyde + H2O + NAD(+) + trimethylamine => choline + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.13", "l": "\"ADP-ribose diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.49", "l": "\"[pyruvate kinase]-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50814", "l": "1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008776", "l": "acetate kinase activity", "d": ["Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47003", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61466", "l": "a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656259", "l": "Defective HEXA does not cleave the terminal GalNAc from DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62622", "l": "[thioredoxin]-disulfide + an alcohol + H2O => [thioredoxin]-dithiol + a hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69552", "l": "dihydroxyacetone phosphate + L-glutamate = (S)-serinol phosphate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53669", "l": "(2E,6E)-farnesyl diphosphate => (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12099", "l": "H2O + N-benzylformamide <=> benzylamine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42622", "l": "(Z)-2-methylaminoacrylate + CO2 + NH4(+) => (Z)-2-methylureidoacrylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013143", "l": "RAC1 GEFs activate RAC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52377", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618107", "l": "ATP binding to HSP90 triggers conformation change (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71912", "l": "cholate(out) + 2 Na(+)(out) => cholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662608", "l": "MT2A binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265862", "l": "Association of RAD51 with BRCA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63615", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-5-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617859", "l": "Retinoic acid activates HOXB4 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73772", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549304", "l": "OCT3 mediates renal clearance of organic cations (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11656", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline = AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.53", "l": "\"L-proline--[L-prolyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70926", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) <=> (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840408", "l": "OMA1 cleaves DELE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52598", "l": "3-oxocholan-24-oyl-CoA + H(+) + NADH => lithocholoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015528", "l": "lactose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807496", "l": "POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050187", "l": "phosphoamidase activity", "d": ["Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65337", "l": "chrodrimanin T + H(+) + NADPH + O2 => chrodrimanin A + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015135", "l": "glucuronate transmembrane transporter activity", "d": ["Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062213", "l": "peroxynitrite isomerase activity", "d": ["Catalysis of the reaction: peroxynitrite = nitrate."], "t": []}, {"i": "RHEA:63116", "l": "peroxynitrite = nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031823", "l": "type 1D serotonin receptor binding", "d": ["Binding to a type 1D serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635868", "l": "ub-GLI is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62705", "l": "glycyldehydrophenylalanine + H2O => 2,3-didehydrophenylalanine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23299", "l": "aceneuramate <=> N-acetyl-D-mannosamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047666", "l": "ammonia kinase activity", "d": ["Catalysis of the reaction: ATP + NH4 = ADP + 3 H+ + phosphoramidate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48963", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58947", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH <=> 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64896", "l": "2 H2O + UTP = 2 H(+) + 2 phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130731", "l": "Formation of COPII vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59222", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+) => (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474210", "l": "Collagen type III degradation by MMP14 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10266", "l": "beta-D-glucose => alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40196", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351341", "l": "Exocytosis of Proactivator polypeptide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66802", "l": "2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37626", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21110", "l": "2-methylbutanal + CO2 => (S)-3-methyl-2-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0002060", "l": "purine nucleobase binding", "d": ["Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052770", "l": "coenzyme F390-A hydrolase activity", "d": ["Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33590", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate <=> CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.148", "l": "\"lycopaoctaene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606326", "l": "HJURP:CENPA complex localizes to the centromere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.27", "l": "\"coagulation factor XIa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30360", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 => chlorophyllide b + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64285", "l": "2-phenylethylamine + pyruvate => 2-phenylacetaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38880", "l": "a fatty acid(in) => a fatty acid(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001918", "l": "farnesylated protein binding", "d": ["Binding to a farnesylated protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112156", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013881", "l": "Cables1 links CDK2 and WEE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37513", "l": "1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47088", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018546", "l": "nitrobenzene nitroreductase activity", "d": ["Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031879", "l": "type 2 somatostatin receptor binding", "d": ["Binding to a type 2 somatostatin receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691421", "l": "BTK binds BTK inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50600", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196964", "l": "RFK:Mg2+ phosphorylates RIB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438026", "l": "Activation and dimerization of c-JUN in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35058", "l": "3,6-dichlorocatechol + O2 <=> (2E,4E)-2,5-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34112", "l": "carboxyspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69293", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => goitrin + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72000", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52348", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007522", "l": "E2F6 binds APAF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40723", "l": "(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53431", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] <=> a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72057", "l": "glycodeoxycholate(in) + 2 Na(+)(in) => glycodeoxycholate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950778", "l": "p-Y693-STAT4 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102481", "l": "3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity", "d": ["Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46638", "l": "H(+) + NADPH + testosterone => 5beta-dihydrotestosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72208", "l": "chloride(out) + 2 hydrogencarbonate(in) => chloride(in) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481007", "l": "Exocytosis of platelet alpha granule contents (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40356", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863012", "l": "Calpain cleaves p35 to p25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69054", "l": "3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+) => H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38607", "l": "2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35916", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229283", "l": "LCNs bind lipids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41532", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": [], "t": []}, {"i": "EC:1.14.16.7", "l": "\"phenylalanine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43225", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31622", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58645", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990362", "l": "butanol dehydrogenase activity", "d": ["Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+."], "t": []}, {"i": "RHEA:33199", "l": "butan-1-ol + NAD(+) = butanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24171", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809764", "l": "SBF1 binds MTMR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190682", "l": "Connexin synthesis (generic) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380157", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38139", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55052", "l": "H2O + pentanoyl-CoA = CoA + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53624", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + tsukubadiene", "d": [], "t": []}, {"i": "EC:4.2.3.159", "l": "\"tsukubadiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748991", "l": "XDH oxidises 6MP to 6TU (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37186", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20705", "l": "a D-alpha-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800380", "l": "PTPRD binds IL1RAP-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17553", "l": "ATP + guanidinoethyl methyl phosphate = ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": [], "t": []}, {"i": "EC:2.7.3.7", "l": "\"opheline kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018597", "l": "ammonia monooxygenase activity", "d": ["Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40452", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10379", "l": "ATP + Cu(2+)(in) + H2O <=> ADP + Cu(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75253", "l": "3'-dehydrocarminate + H2O2 => carminate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006508", "l": "PVALB gene expression is repressed by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25458", "l": "diphosphate + gamma-humulene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033944", "l": "beta-galactofuranosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38350", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49013", "l": "aurachin C + H(+) + NADH + O2 => aurachin C epoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65458", "l": "2-methylbutyl acetate + CoA => 2-methylbutan-1-ol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195275", "l": "Phosphorylation of APC component of the destruction complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661086", "l": "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375148", "l": "Interaction of NCAM1 with Neurocan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58367", "l": "a medium-chain primary fatty alcohol + NADP(+) <=> a medium-chain fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46336", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O = 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696131", "l": "AOC1 deaminates Hist (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936563", "l": "ISGylation of DDX58 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18674", "l": "ATP + L-seryl-[receptor-protein] => ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13955", "l": "a D-alpha-amino acid + a tRNA + H(+) => a D-aminoacyl-tRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51330", "l": "10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380586", "l": "loading of Serotonin in synaptic vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425861", "l": "Activation of Protein Kinase C novel isoforms (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15566", "l": "an N-acyl-L-amino acid + H2O => a carboxylate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641147", "l": "DACT1 binds DVL2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654399", "l": "Activated FGFR2 binds FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63199", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH <=> (10bR,4aS)-oxomaritidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76130", "l": "3',5'-cyclic AMP(out) + a dicarboxylate(in) <=> 3',5'-cyclic AMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10694", "l": "H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone => 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24290", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine => 5-formimidoyltetrahydrofolate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40894", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110219", "l": "Cleavage of thymine by TDG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392834", "l": "Activation of EPACs by cAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73159", "l": "FMN(out) + NAD(+)(in) = FMN(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60165", "l": "a guanosine in RNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33299", "l": "[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": [], "t": []}, {"i": "EC:2.5.1.46", "l": "\"deoxyhypusine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51224", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191303", "l": "FDPS dimer transfers IPPP to GPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77432", "l": "a ganglioside GT2 + UDP-alpha-D-galactose => a ganglioside GT1c + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019834", "l": "phospholipase A2 inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of phospholipase A2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36761", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62620", "l": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.24", "l": "\"thioredoxin-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26524", "l": "2-methyl-trans-aconitate + H2O => (2S,3S)-2-methylcitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36392", "l": "cholesterol + NADP(+) => desmosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114354", "l": "SMAC binds XIAP:Caspase-7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28436", "l": "((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP] => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052640", "l": "salicylic acid glucosyltransferase (glucoside-forming) activity", "d": ["Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30347", "l": "ATP + IDP = ADP + ITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37084", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine => [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77606", "l": "2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) <=> 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48673", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11158", "l": "3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+) => H2O + L-valine + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19414", "l": "ATP + L-phenylalanine + tRNA(Phe) => AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40208", "l": "(2E)-tetradecenedioyl-CoA + H2O => (3S)-hydroxytetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654167", "l": "Activated FGFR1 binds PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50492", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16042", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate => [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39009", "l": "a cholesterol ester(out) => a cholesterol ester(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59465", "l": "NADP(+) + octadecan-1-ol => H(+) + NADPH + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450348", "l": "Activated human JNKs migrate to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20406", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944220", "l": "Association of procollagen type XXIII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33338", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001162", "l": "RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "d": ["Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404134", "l": "RBP4:atROL binds TTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.46", "l": "\"adamalysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22684", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.65", "l": "\"4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11742", "l": "glutathione disulfide + H(+) + NADPH => 2 glutathione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67656", "l": "2 Fe(III)-[cytochrome c] + NADPH = 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209187", "l": "Further phosphorylation of CI by CKIalphaepsilon (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67774", "l": "a 5'-end dephospho-ribonucleoside-RNA + phosphate => a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42324", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) = 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.5.7.2", "l": "\"coenzyme F420 oxidoreductase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.246", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004777", "l": "succinate-semialdehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20212", "l": "ATP + xylitol <=> ADP + H(+) + xylitol 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350901", "l": "Iodide is organified (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34247", "l": "1-deoxymethyl-sphinganine + NADP(+) = 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21130", "l": "fecosterol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77281", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050572", "l": "L-idonate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17755", "l": "(S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine => S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008398", "l": "sterol 14-demethylase activity", "d": ["Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66489", "l": "quillate + UDP-alpha-D-glucose => quillaic acid 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24815", "l": "3-methyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44314", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14700", "l": "(2E,6E)-farnesol + NADP(+) <=> (2E,6E)-farnesal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.57", "l": "\"long-chain fatty acid adenylase/transferase FadD23\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948136", "l": "ULK1 Translocates to the mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35235", "l": "H(+)(out) + tetracycline(in) = H(+)(in) + tetracycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59950", "l": "CoA + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52137", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990948", "l": "ubiquitin ligase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ubiquitin ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70114", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48515", "l": "ATP + H2O + phosphinate(out) <=> ADP + H(+) + phosphate + phosphinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209891", "l": "Dopamine is oxidised to noradrenaline (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180024", "l": "membrane grommet activity", "d": ["An activity in which a protein, or group of proteins, acts to restrict the size of a fenestration in a membrane or membrane system (i.e. restrict the diameter of a hole in a membrane). An example of this is the molecular function is performed by ESCRT-III proteins at the nuclear envelope of fission yeast during anaphase B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27534", "l": "(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.49", "l": "\"(3R,6E)-nerolidol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15330", "l": "(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446634", "l": "IRAK4 is activated by autophosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419003", "l": "Interaction of Nectins with Afadin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112604", "l": "Phosphorylated STATs are released (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50956", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71693", "l": "glycyl-L-glutamate(in) + 2 H(+)(in) => glycyl-L-glutamate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034986", "l": "iron chaperone activity", "d": ["Directly binding to and delivering iron ions to a target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76638", "l": "n H(+)(out) + Mn(2+)(in) <=> n H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607342", "l": "Expression of FABP6 regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72701", "l": "NAD(+) + propanoate => acrylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451366", "l": "Activation of p38MAPK by DSCAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68641", "l": "(2E)-geranyl diphosphate => diphosphate + limonene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47190", "l": "hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] => Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24976", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046566", "l": "DOPA dioxygenase activity", "d": ["Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42497", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate => 10-deacetyl-2-debenzoylbaccatin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41362", "l": "H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014129", "l": "HEY1 gene expression is positively regulated by NOTCH3 and STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684032", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61338", "l": "ADP + H(+) + phosphate + protoporphyrin IX(out) => ATP + H2O + protoporphyrin IX(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16971", "l": "dTDP-4-dehydro-beta-L-rhamnose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47638", "l": "5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+) => H2O + L-arginine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10238", "l": "H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP => trans-2-coumarate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41290", "l": "H2O + N-tetradecanoylsphing-4-enine <=> sphing-4-enine + tetradecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34808", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72621", "l": "Ribosomal scanning  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837543", "l": "hRSV A enters host cell through membrane fusion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62631", "l": "a hydroperoxide + H(+) + NADH <=> an alcohol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54973", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19192", "l": "H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate <=> CO2 + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60117", "l": "2-oxoglutarate + methylphosphonate + O2 => CO2 + hydroxymethylphosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24040", "l": "NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30920", "l": "A + rhodopin => (3E)-3,4-didehydrorhodopin + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641206", "l": "RSPOs bind LGRs (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620717", "l": "p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69341", "l": "(E)-prop-1-en-1-SO-peroxol => (Z)-propanethial S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664991", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11696", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": [], "t": []}, {"i": "EC:2.1.1.139", "l": "\"3'-demethylstaurosporine O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098620", "l": "seryl-selenocysteinyl-tRNA kinase activity", "d": ["Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP."], "t": []}, {"i": "REACT:R-HSA-2408507", "l": "Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76012", "l": "(3R)-hydroxybutanoate tetramer + H2O => (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33651", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56074", "l": "a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP => a 2-acylphloroglucinol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936851", "l": "AHRR binds ARNT (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11451", "l": "NAD(+) + pregnan-21-ol <=> H(+) + NADH + pregnan-21-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730843", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17656", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021520", "l": "NOTCH3 binds WWP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904768", "l": "all-trans-retinol binding", "d": ["Binding to all-trans-retinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43432", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] = butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.9", "l": "\"1-butanol dehydrogenase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220959", "l": "TDG excises 5-formylcytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31667", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.89", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64018", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427337", "l": "MBD2 binds methylcytosine in chromatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57654", "l": "a ganglioside GM1alpha + CMP + H(+) => a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24521", "l": "H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69857", "l": "a uridine in mRNA + H(+) + NADPH => a 5,6-dihydrouridine in mRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875451", "l": "MET phosphorylates CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72543", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) = 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38247", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450348", "l": "Activated human JNKs migrate to nucleoplasm (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44168", "l": "dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20003", "l": "glycolate + 2 H(+) + NADH => glycolaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35759", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54552", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20086", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA => a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33947", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine = 2'-N-acetylparomamine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.283", "l": "\"2-deoxystreptamine N-acetyl-D-glucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111966", "l": "GRK2 binds CALM1:4Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15010", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) => 7,8-dihydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75856", "l": "Abortive Initiation Before Second Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65759", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] <=> (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102844", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352945", "l": "fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16777", "l": "ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.6", "l": "\"P-type K(+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59367", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27745", "l": "2'-deoxyadenosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631941", "l": "SESN1,2,3 bind AMPK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689111", "l": "PARK2 autoubiquitinates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65416", "l": "dGMP(in) + NAD(+)(out) = dGMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72201", "l": "Ca(2+)(out) + 2 H(+)(in) => Ca(2+)(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63446", "l": "GMP + H(+) + oxidized coenzyme F420-0 => (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203479", "l": "STAB2 (FEEL-2) binds ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990308", "l": "type-I dockerin domain binding", "d": ["Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836435", "l": "p-PKR dimer phosphorylates SNCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48972", "l": "ATP + H2O + phosphite(out) = ADP + H(+) + phosphate + phosphite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874685", "l": "CBL binds MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247569", "l": "PADI4 deiminates Histones (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446364", "l": "Migfilin interacts with VASP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56359", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102438", "l": "laricitrin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine = H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25035", "l": "all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45723", "l": "N-hexadecanoylsphing-4-enine(in) <=> N-hexadecanoylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66700", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64320", "l": "(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62985", "l": "H2O + hexadecanamide => hexadecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799097", "l": "ATM phosphorylates ZNF420 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25837", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => 5-deoxy-D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11640", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24597", "l": "acetyl-CoA + L-histidine => CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202947", "l": "Caspase mediated cleavage of APC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507870", "l": "Aquaporins passively transport water out of cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66712", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12757", "l": "dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin", "d": [], "t": []}, {"i": "EC:1.3.1.69", "l": "\"zeatin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011300", "l": "ZSWIM8 ubiquitinates ROBO3.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16378", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694630", "l": "Nsp3:nsp4 binds to nsp6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-873917", "l": "Translocation of STAT1 dimer to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30755", "l": "ATP + carbamate = ADP + carbamoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218812", "l": "FYN phosphorylates PAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60099", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948034", "l": "FGR binds LDL:LRP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68491", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) <=> CO2 + H2O + tridecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015379", "l": "potassium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32334", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) <=> (1S,4R)-fenchone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694499", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093331", "l": "Ras:GTP binds p120-RasGAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12731", "l": "(3R,3'S)-zeaxanthin => lutein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017025", "l": "TBP-class protein binding", "d": ["Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57335", "l": "H2O + 3 O2 + 3 propionate 3-nitronate <=> 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.26", "l": "\"fructosyl amine oxidase (fructosamine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73760", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047673", "l": "anthranilate N-malonyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667809", "l": "KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671737", "l": "p-T774-PKN1 binds CDC25C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61343", "l": "(S)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755303", "l": "26S proteasome degrades HIFalpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76707", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2059926", "l": "NPHP4 protein binds LATS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68715", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,2S,4R)-beta-elemene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10199", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate <=> 2-succinylbenzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0061459", "l": "L-arginine transmembrane transporter activity", "d": ["Enables the transfer of L-arginine from one side of a membrane to the other."], "t": []}, {"i": "RHEA:32143", "l": "L-arginine(in) = L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70033", "l": "castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17503", "l": "16-epivellosimine + CO2 + methanol => H2O + polyneuridine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.4.7", "l": "\"hydroperoxy icosatetraenoate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20927", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine <=> a [peptide]-C-terminal amide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74722", "l": "myricetin + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30830", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47429", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) => 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867613", "l": "PICALM binds R-SNAREs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33729", "l": "a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66675", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) <=> 5,7-dihydroxy-4-methylphthalide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018809", "l": "E-phenylitaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166538", "l": "The bound receptor dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47552", "l": "glycodeoxycholate + H2O = deoxycholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40628", "l": "H2O + trihexadecanoylglycerol => 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785762", "l": "IL13RA1 binds TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102996", "l": "beta,beta digalactosyldiacylglycerol galactosyltransferase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol = a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77016", "l": "(S)-leucinol + H2O + NAD(+) => 1-hydroxy-4-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44736", "l": "acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.245", "l": "\"3-hydroxy-5-phosphooxypentane-2,4-dione thiolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60577", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] => Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60848", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68646", "l": "alpha-thujene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050563", "l": "trans-feruloyl-CoA synthase activity", "d": ["Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017032", "l": "amino acid:potassium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372542", "l": "Loading of dopamine into synaptic veiscles (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209271", "l": "N-HH moves from the cytosol to the extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57935", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64230", "l": "1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40957", "l": "ADP + CO2 + isopentenyl phosphate + phosphate => (R)-5-phosphomevalonate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480520", "l": "Expression of SALL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47142", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57717", "l": "hydrogencarbonate + NH4(+) => carbamate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377640", "l": "Autophosphorylation of SRC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849085", "l": "ARHGAP35 binds RHOA:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48679", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856951", "l": "PP2A demethylation by PPME1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63339", "l": "alpha-D-xylose <=> beta-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65389", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047022", "l": "7-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47093", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) => dipicolinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17211", "l": "2-formylglutarate + NH4(+) => 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13809", "l": "aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.35", "l": "\"aspulvinone dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55172", "l": "2-oxoglutarate + hexanoyl-CoA + O2 = 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876472", "l": "NPC2 binds CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247847", "l": "WLS is endocytosed to the early endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46160", "l": "a quinone + H(+) + NADH = a quinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75034", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate <=> (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46729", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69080", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) = 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874205", "l": "MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196017", "l": "Dynamin is recruited to the gap junction plaque (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70164", "l": "H(+)(in) + methotrexate(in) => H(+)(out) + methotrexate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23550", "l": "H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(966) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30256", "l": "2 a ubiquinol + O2 => 2 a ubiquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14566", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004190", "l": "aspartic-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46829", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54293", "l": "ATP + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71513", "l": "phylloquinone(in) => phylloquinone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40083", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445064", "l": "Activation of Rac1 by VAV2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58385", "l": "NADP(+) + octan-1-ol => H(+) + NADPH + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38301", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68117", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol => a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709179", "l": "DPP4 binds DPP4 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62366", "l": "(Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28674", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59155", "l": "ATP + CoA + pseudomonate C <=> AMP + diphosphate + pseudomonoyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31040", "l": "dodecanoyl-CoA + FAD + H(+) => (2E)-dodecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669158", "l": "NF2 binds PAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016648", "l": "oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide."], "t": []}, {"i": "EC:1.5.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709842", "l": "MAVS binds TOMM70 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56936", "l": "17beta-hydroxy-androst-5-en-3-one = testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57843", "l": "1D-myo-inositol 1,3-bisphosphate + H2O <=> 1D-myo-inositol 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40383", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60766", "l": "cinerin II + CoA => (1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76309", "l": "L-aspartate(out) + L-glutamate(in) => L-aspartate(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19486", "l": "sphing-4-enine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631885", "l": "PRDX1 overoxidizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53649", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008526", "l": "phosphatidylinositol transfer activity", "d": ["Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30061", "l": "orotate + succinate => (S)-dihydroorotate + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32141", "l": "AMP + diphosphate + malonyl-CoA => ATP + CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875817", "l": "MET phosphorylates STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432642", "l": "Phosphorylated TIM transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254291", "l": "ERBB4s80 binds STAT5A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63836", "l": "hexadecanoate + O2 = (2R)-2-hydroperoxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40092", "l": "26-hydroxyhexacosanoate + NAD(+) => 26-oxohexacosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870461", "l": "RABGGTA and RABGGTB bind (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0097508", "l": "xanthine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated guanine (xanthine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18865", "l": "2-methylpropanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = CoA + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.3.1.168", "l": "\"dihydrolipoyllysine-residue (2-methylpropanoyl)transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48880", "l": "a quinone + CO + H2O = a quinol + CO2", "d": [], "t": []}, {"i": "EC:1.2.5.3", "l": "\"aerobic carbon monoxide dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70912", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57079", "l": "3-oxoisoapionate 4-phosphate + H2O <=> (2R)-3-phosphoglycerate + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199910", "l": "MSK1 activates ATF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070626", "l": "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "d": ["Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40910", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77139", "l": "1D-myo-inositol 2,3-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42398", "l": "2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine => cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14370", "l": "2-phosphoglycolate + H2O => glycolate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.59", "l": "\"5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25255", "l": "ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate => ATP + N-acetyl-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "50.35228396812694", "identifiers": [{"i": "GO:0008324", "l": "monoatomic cation transmembrane transporter activity", "d": ["Enables the transfer of cation from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202500", "l": "Activation of IKK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10225", "l": "ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67098", "l": "CO2 + fumigatonoid A + succinate => 2-oxoglutarate + asnovolin A + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578712", "l": "Importin-8 binds AGO2:miRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45261", "l": "tetracosanoate(out) => tetracosanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62470", "l": "3,4-dihydroxybenzoyl-5'-AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30402", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004090", "l": "carbonyl reductase (NADPH) activity", "d": ["Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63544", "l": "H2O + kinetensin = kinetensin-(1-8) + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13318", "l": "(2R,3R)-tartrate + H(+) => (R)-glycerate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76598", "l": "a dicarboxylate(in) + sulfate(out) <=> a dicarboxylate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34739", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine = H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990174", "l": "phosphodiesterase decapping endonuclease activity", "d": ["Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.1", "l": "\"iron:rusticyanin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046026", "l": "precorrin-4 C11-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56754", "l": "a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55203", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine <=> 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24388", "l": "phosphate + uridine = alpha-D-ribose 1-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297354", "l": "Acrosin Cleavage (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24605", "l": "7-methylxanthine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24793", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": [], "t": []}, {"i": "EC:4.3.2.10", "l": "\"imidazole glycerol-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033529", "l": "TYSND1 cleaves ACAA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114254", "l": "CYCS binds to APAF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29603", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] = 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.1.7.1", "l": "\"4-hydroxybenzoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58419", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.322", "l": "\"(-)-endo-fenchol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247840", "l": "WLS binds WNT ligands in the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53691", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18405", "l": "H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:1.4.1.1", "l": "\"alanine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001081", "l": "(1->4)-beta-D-galactan binding", "d": ["Binding to (1->4)-beta-D-galactan."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10421", "l": "pyruvate + taurine => L-alanine + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34415", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70726", "l": "sitosterol(out) <=> sitosterol(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51240", "l": "(9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948136", "l": "ULK1 Translocates to the mitochondria (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11303", "l": "1D-5-O-methyl-myo-inositol + NAD(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20335", "l": "ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase] => ATP + L-seryl-[acetyl-CoA carboxylase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70852", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66701", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612509", "l": "SGK phosphorylates SRF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23006", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73953", "l": "beta-maaliene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72671", "l": "eIF5B:GTP is hydrolyzed and released (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32879", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) = (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.327", "l": "\"5-exo-hydroxycamphor dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13164", "l": "L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786650", "l": "DDHD1,2 hydrolyse PA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36490", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707516", "l": "FeHM dissociates from MetHb (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16721", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.5.98.1", "l": "\"methylenetetrahydromethanopterin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67333", "l": "13-cis-retinal + H2O + NAD(+) => 13-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199154", "l": "CD200 binds to CD200R (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800797", "l": "The PIDDosome activates CASP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44362", "l": "3-hydroxy-2,4-dioxopentyl phosphate => (2S)-2-hydroxy-3,4-dioxopentyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818574", "l": "TASP1 cleaves KMT2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796368", "l": "RIPK1 binds STUB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14614", "l": "ATP + H2O + taurine(out) => ADP + H(+) + phosphate + taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70221", "l": "20beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12626", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose => D-glucose + sinapoyl (S)-malate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40016", "l": "(+)-copalyl diphosphate + H2O => 13-epi-manool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.66", "l": "\"phosphatidylinositol-3,4-bisphosphate 4-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52081", "l": "12-octadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46327", "l": "3-oxochol-4-en-22-oyl-CoA + A <=> 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55157", "l": "a quinone + glutathione + H(+) + hydrogen sulfide => a quinol + S-sulfanylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173636", "l": "Formation of classic pathway C5 convertase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980125", "l": "ITCH binds DTX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18261", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.152", "l": "\"precorrin-6A synthase (deacetylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167090", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33206", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65139", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28491", "l": "H(+)(in) + K(+)(in) => H(+)(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58146", "l": "AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetate + ATP + cytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25488", "l": "(2E)-geranyl diphosphate = (1S,5S)-alpha-pinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.119", "l": "\"(-)-alpha-pinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50788", "l": "NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805981", "l": "HMGB1 release from cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22520", "l": "all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34502", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928578", "l": "EPH receptors autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70257", "l": "cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine => 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28142", "l": "H2O + streptothricin D = streptothricin D acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170978", "l": "p-FRS2:CRKL binds C3G (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726509", "l": "NR3C2 binds fludrocortisone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052739", "l": "phosphatidylserine 1-acylhydrolase activity", "d": ["Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.106", "l": "\"hepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47026", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+) => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42903", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69356", "l": "H(+) + hypobromite + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70079", "l": "2-oxoglutarate + clavatol + O2 = CO2 + hydroxyclavatol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57336", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52295", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72843", "l": "3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016436", "l": "rRNA (uridine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174445", "l": "RPA binds to the Flap on the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75384", "l": "bromide(in) => bromide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380930", "l": "Phosphorylated AMPK binds AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73283", "l": "H(+)(out) + L-isoleucine(in) = H(+)(in) + L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24212", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.50", "l": "\"hydroxyethylthiazole kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31444", "l": "ATP + D-sedoheptulose 7-phosphate => ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696275", "l": "RND2 binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12823", "l": "acetaldehyde + D-glyceraldehyde 3-phosphate => 2-deoxy-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9769235", "l": "MAGED1 binds NPAS4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31766", "l": "a 2-oxocarboxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58834", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015225", "l": "biotin transmembrane transporter activity", "d": ["Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."], "t": []}, {"i": "RHEA:28458", "l": "biotin(in) = biotin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22666", "l": "1,2-di-O-sinapoyl beta-D-glucose + D-glucose => 2 1-O-(trans-sinapoyl)-beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004757", "l": "sepiapterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33743", "l": "an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44455", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693347", "l": "HTR1A binds 5HT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19305", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.151", "l": "\"2,3',4,6-tetrahydroxybenzophenone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3782637", "l": "HDAC8 deacetylates histones (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28419", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA => (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28297", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71840", "l": "dehydroepiandrosterone 3-sulfate(out) => dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140770", "l": "CoA-dependent peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N(6)-tetradecanoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:59752", "l": "L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74117", "l": "an anthocyanidin 3-O-beta-D-galactoside + UDP => an anthocyanidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66010", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869683", "l": "oxPL binds LBP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35128", "l": "L-alanyl-D-glutamate(out) => L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21012", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}, {"i": "EC:2.4.1.70", "l": "\"poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008679", "l": "2-hydroxy-3-oxopropionate reductase activity", "d": ["Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70193", "l": "3'-NADP(+) + ADP + H(+) => ATP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19874", "l": "dehydroepiandrosterone 3-sulfate + H2O => 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59915", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0003684", "l": "damaged DNA binding", "d": ["Binding to damaged DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28984", "l": "nitrite(in) => nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047809", "l": "D-2-hydroxy-acid dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080059", "l": "flavonol 3-O-arabinosyltransferase activity", "d": ["Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982792", "l": "Growth hormone receptor binds JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29619", "l": "alpha-maltotetraose + beta-maltose = alpha-maltopentaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55990", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39420", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654425", "l": "Activated FGFR4 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71539", "l": "H(+)(out) + 2 nitrate(out) = H(+)(in) + 2 nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6804099", "l": "HMGB1 binds LTP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77531", "l": "hydrogen cyanide + nonanal = (2S)-2-hydroxydecanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15519", "l": "H(+) + N-sulfo-D-glucosamine + sulfate => H2O + N(2),6-disulfo-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193646", "l": "NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76547", "l": "acetyl-CoA + D-glutamine = CoA + H(+) + N-acetyl-D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21011", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) <=> diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47776", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265177", "l": "Exocyst complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50709", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768788", "l": "miR-224 binds NPAS4 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17561", "l": "acetylcholine + H2O = acetate + choline + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.7", "l": "\"acetylcholinesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18939", "l": "a carboxylate + L-homoserine lactone => an N-acyl-L-homoserine lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25226", "l": "L-arabinitol + NAD(+) => H(+) + L-arabinose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010521", "l": "telomerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of telomerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654409", "l": "Activated FGFR3 binds FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1369052", "l": "ABCAs mediate lipid influx (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50320", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70067", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54320", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36489", "l": "H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine => agmatine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55466", "l": "11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389354", "l": "Activation of Vav1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22865", "l": "L-lysine => D-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373717", "l": "DCC interacts with DIP13alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983153", "l": "E1 mediated ubiquitin activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48321", "l": "a ganglioside GA1 + GDP-beta-L-fucose => a ganglioside Fuc-GA1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65628", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45957", "l": "(9Z)-octadecenoyl-CoA(in) => (9Z)-octadecenoyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629245", "l": "NEIL3 D132V does not cleave 5-guanidinohydantoin (Gh) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.113", "l": "\"mannosyl-oligosaccharide 1,2-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656244", "l": "DRD2 binds DA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831948", "l": "P:PP1 dephosphorylates M2-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685605", "l": "SLAMF7 binds SLAMF7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60202", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0140848", "l": "amino acid:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60606", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44342", "l": "AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + ATP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847968", "l": "PTEN binds FRK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.17", "l": "\"enoyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60879", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51319", "l": "(9Z)-octadecenoate + glycine <=> H2O + N-(9Z-octadecenoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40019", "l": "ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70820", "l": "L-homoarginine(in) + L-ornithine(out) => L-homoarginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047799", "l": "cyclopentanone monooxygenase activity", "d": ["Catalysis of the reaction: cyclopentanone + H+ + NADPH + O2 = 5-valerolactone + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70344", "l": "chloride + L-tyrosine + NADP(+) => 3-chloro-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46456", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50009", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 => 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205136", "l": "GTP-bound RAC contributes to JNK activation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27346", "l": "FMNH2 + O2 => 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51499", "l": "a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419049", "l": "ROCK activation by RHO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140432", "l": "5'-hydroxyl dinucleotide hydrolase activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54346", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.2", "l": "\"dihydropyrimidinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0003905", "l": "alkylbase DNA N-glycosylase activity", "d": ["Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40354", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626256", "l": "HSPA8:LAMP2a multimers depolymerizes to monomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32545", "l": "1,8-cineole + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451900", "l": "IL2RB binds JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32865", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112037", "l": "Inactivation of PLC beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25381", "l": "2-methylpentadecanal + formyl-CoA => 2-hydroxy-3-methylhexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0008527", "l": "taste receptor activity", "d": ["Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29460", "l": "beta-alanine(in) + H(+)(in) => beta-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44254", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59493", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37630", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35735", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25981", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67898", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine => a 3'-end uridylyl-adenosine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44992", "l": "(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2-methylbutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33094", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.6", "l": "\"ABC-type lipid A-core oligosaccharide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665524", "l": "ATP translocates from cytosol to extracellular space (stimuated by C3AR1:C3a) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74162", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32365", "l": "H(+) + H2O2 + L-ascorbate => L-gulono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863973", "l": "Fusion of ERC and phagosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43311", "l": "1-hexadecanoyl-sn-glycerol + ATP <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54239", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline <=> 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110036", "l": "C2 domain binding", "d": ["Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649108", "l": "HTR3A pentamer binds 5HT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141367", "l": "Myristoylation of tBID by NMT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204863", "l": "Interaction of Tie2 with Ang2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296244", "l": "SUCNR1 binds SUCCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793955", "l": "Defective MGAT2 does not transfer GlcNAc to N-glycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167415", "l": "G-protein alpha subunit is inactivated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11089", "l": "H2O + trimetaphosphate => 2 H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32700", "l": "(2E,6E)-farnesyl diphosphate => beta-sesquiphellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140771", "l": "ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the reaction: hexadecanoyl-[ACP] + L-lysyl-[protein] = H+ + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:70615", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72425", "l": "(E)-4-coumaroyl-CoA + AMP + H(+) => (E)-4-coumaroyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008523", "l": "sodium-dependent multivitamin transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41334", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66790", "l": "(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-L-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836270", "l": "TFAP2A binds TFAP2C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905762", "l": "CCR4-NOT complex binding", "d": ["Binding to a CCR4-NOT complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12478", "l": "formate + L-glutamate => H2O + N-formyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016933", "l": "extracellularly glycine-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10397", "l": "an L-alpha-amino acid + H2O + NAD(+) => a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31351", "l": "lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.128", "l": "\"lupan-3beta,20-diol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.18", "l": "\"polysaccharide O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56337", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086410", "l": "CDK1 phosphorylates BORA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684096", "l": "CDK2 phosphorylates RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229138", "l": "MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36678", "l": "octacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727300", "l": "9b homodimer localizes to the mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423656", "l": "AFXBO hydrolyses non-enzymatically to AFBDHD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191830", "l": "snRNP nuclear import and release (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75616", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => ectocarpin B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73571", "l": "(E,E)-piperate + ATP + CoA = (E,E)-piperoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21691", "l": "a polyvinyl alcohol + n O2 <=> an oxidized polyvinyl alcohol + n H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30007", "l": "ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66294", "l": "an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22025", "l": "H2O + NAD(+) + trimethylamine => 2 H(+) + NADH + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42857", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030758", "l": "3,7-dimethylquercitin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48744", "l": "(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.8", "l": "\"(-)-deoxypodophyllotoxin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19077", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734475", "l": "PPARA binds fibrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48450", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine => a ganglioside GA2 + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38213", "l": "1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA => hexadecane-1,2-diol + 2 hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63833", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine => capsaicin + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675947", "l": "TNFSF18 binds TNFRSF18 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047123", "l": "quinoline-4-carboxylate 2-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170978", "l": "p-FRS2:CRKL binds C3G (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41366", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2471842", "l": "Collagen type XXV ectomain shedding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18112", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043274", "l": "phospholipase binding", "d": ["Binding to a phospholipase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49591", "l": "L-erythrulose 1-phosphate <=> D-erythrulose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37135", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39461", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39050", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42984", "l": "(+)-copalyl diphosphate = diphosphate + pimara-8(14),15-diene", "d": [], "t": []}, {"i": "EC:4.2.3.147", "l": "\"pimaradiene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.41", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65581", "l": "H2O + TTP => H(+) + phosphate + TDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202489", "l": "Oligomerization of Bcl10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008390", "l": "testosterone 16-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60453", "l": "2-hydroxyethane-1-sulfonate => acetaldehyde + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16899", "l": "a 3beta-hydroxysteroid ester + a diacylglycerol => a 3beta-hydroxysteroid + a triacylglycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109860", "l": "MAP2K1 phosphorylates MAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784959", "l": "BPHL hydrolyses VACV to ACV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10986", "l": "(S)-malate + pyruvate => (S)-lactate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047802", "l": "cysteine-conjugate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0016433", "l": "rRNA (adenine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938913", "l": "RUNX1 binds ELF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20724", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56184", "l": "a globoside Gb4Cer + UDP-alpha-D-galactose = a globoside NOR1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36536", "l": "docosanoyl-CoA + sphinganine => CoA + H(+) + N-docosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44825", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53947", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) <=> (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362485", "l": "GHBP binds GH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017058", "l": "FH1 domain binding", "d": ["Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36516", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA => 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62377", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O => (S)-lactate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610735", "l": "NUMB binds ITCH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59583", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19351", "l": "(R)-3,3-dimethylmalate + 2 H(+) + NADH => (R)-4-dehydropantoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373747", "l": "Phosphorylation of nephrin by FYN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26279", "l": "Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-4 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983077", "l": "STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031626", "l": "beta-endorphin binding", "d": ["Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944538", "l": "miR-22 microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70947", "l": "L-tryptophan(in) = L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2423785", "l": "CR:atREs binds apoE and HSPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004567", "l": "beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12028", "l": "H2O + L-5-carboxymethylhydantoin = H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.2.4", "l": "\"carboxymethylhydantoinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-901047", "l": "Binding of ERp57 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18286", "l": "an N-acyl-D-aspartate + H2O => a carboxylate + D-aspartate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25344", "l": "carbamate + NH4(+) => H2O + urea", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50674", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21371", "l": "H2O + O2 + urate <=> 5-hydroxyisourate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19492", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide <=> 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.37", "l": "\"FAD reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.116", "l": "\"averantin hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9834821", "l": "p-PRKRA dimer binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371527", "l": "HSF1 trimer translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73427", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] = H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31674", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42749", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17876", "l": "an R-cob(III)alamin(out) + ATP + H2O <=> ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848414", "l": "Activated PTK6 binds CDKN1B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50324", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36968", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56341", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428522", "l": "Inactivation of RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.42", "l": "\"(4S)-4-hydroxy-2-oxoglutarate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40049", "l": "1,2-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35523", "l": "H(+) + N-ethylmaleimide + NADPH = N-ethylsuccinimide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004025", "l": "alcohol dehydrogenase activity, iron-dependent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44477", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12381", "l": "L-2,4-diaminobutanoate + pyruvate => L-alanine + L-aspartate 4-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033300", "l": "dehydroascorbic acid transmembrane transporter activity", "d": ["Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33126", "l": "all-trans-heptaprenyl diphosphate <=> (R)-tetraprenyl-beta-curcumene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72226", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) <=> 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34194", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.78", "l": "\"GPR endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031886", "l": "type 1 member 3 taste receptor binding", "d": ["Binding to a type 1 member 3 taste receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.96", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56073", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose => a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48183", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.44", "l": "\"(R)-dichlorprop dioxygenase (2-oxoglutarate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24712", "l": "L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose => 2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37881", "l": "aklaviketone => methyl aklanonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64491", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA <=> 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66317", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O => alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112055", "l": "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65496", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH = 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474210", "l": "Collagen type III degradation by MMP14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627056", "l": "Procaspase 9 forms dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77393", "l": "alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc + CMP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30235", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168886", "l": "Hemopexin binds Hemes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10303", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52024", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = 18S-resolvin E2 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.11", "l": "\"dextranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55985", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose => (R)-prunasin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22427", "l": "an S-alkyl-L-cysteine + H2O <=> an alkyl thiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109701", "l": "PDPK1 binds PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047331", "l": "diphosphate-glycerol phosphotransferase activity", "d": ["Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694727", "l": "Endocytosis of protein 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20613", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56486", "l": "gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43541", "l": "ATP + L-seryl-[isocitrate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23193", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75623", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034890", "l": "endosulfan diol hydrolyase (cyclizing) activity", "d": ["Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24804", "l": "2-oxoglutarate + L-isoleucine <=> (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693061", "l": "STAMBP binds STAM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70113", "l": "28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39632", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296043", "l": "Activation of HCN channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41965", "l": "butanoyl-CoA + O2 => (2E)-butenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33714", "l": "4-sulfomuconolactone + H2O <=> 2 H(+) + maleylacetate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013006", "l": "RHOA:GTP translocates to the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445700", "l": "Myosin Binds ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60917", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76712", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione => (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62799", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B <=> aurasperone A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54770", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68784", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + gamma-curcumene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879459", "l": "F-actin capping protein is a heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69127", "l": "Formation of the Flap Intermediate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043338", "l": "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity", "d": ["Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35274", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.21", "l": "\"clavaminate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39548", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866941", "l": "MID1IP1 binds THRSP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55691", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018446", "l": "pinocarveol dehydrogenase activity", "d": ["Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37454", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60940", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18055", "l": "4-nitrophenol + diethylphosphate + 2 H(+) => H2O + paraoxon", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654510", "l": "FGFRL1 binds SPRED1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75887", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602316", "l": "Defective MyD88 does not oligomerize within the complex of activated TLR5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373730", "l": "Neurofascin and NrCAM heterodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70520", "l": "(R)-octopamine + S-adenosyl-L-methionine => (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114284", "l": "Release of Cytochrome c from mitochondria (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3828025", "l": "DCN (decorin) degradation by MMP14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34867", "l": "ATP + CoA + thiophene-2-carboxylate = AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120086", "l": "(3S)-(+)-asterisca-2(9),6-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52035", "l": "H2O + L-isoleucine-(+)-7-isojasmonate <=> (+)-7-isojasmonate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419841", "l": "Light stimulates opsin receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65113", "l": "2-oxoglutarate + aculene D + O2 => aculene C + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.13", "l": "\"2-halobenzoate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56892", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose = NADP(+) + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849906", "l": "SALM1 binds NMDA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41550", "l": "8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66604", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74548", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + talarodiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32729", "l": "a very-long-chain 3-oxoacyl-CoA + CO2 + CoA => a very-long-chain acyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25656", "l": "(2S)-2-amino-3-oxobutanoate + H(+) <=> aminoacetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70474", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60355", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 <=> CO + H(+) + N-octanoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14657", "l": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.6", "l": "\"ribose-5-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33200", "l": "butan-1-ol + NAD(+) => butanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11737", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) => 6-oxocineole + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10206", "l": "formaldehyde + methylamine + reduced [electron-transfer flavoprotein] => dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362386", "l": "Glycosylation of Hh (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112392", "l": "Resumption of elongation after recovery from pausing (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9660192", "l": "VDR agonists bind VDR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454916", "l": "The ABCC family mediates organic anion transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72125", "l": "Na(+)(in) + O-butanoyl-(R)-carnitine(in) => Na(+)(out) + O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800490", "l": "ATM phosphorylates PIDD1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29996", "l": "ATP + H2O + putrescine(out) => ADP + H(+) + phosphate + putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019914", "l": "cyclin-dependent protein kinase activating kinase regulator activity", "d": ["Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15821", "l": "2 A + glycine = 2 AH2 + CO2 + hydrogen cyanide", "d": [], "t": []}, {"i": "EC:1.4.99.5", "l": "\"glycine dehydrogenase (cyanide-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701485", "l": "Active ALK binds JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51412", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67982", "l": "7,8-dihydro-beta-carotene => beta-zeacarotene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75171", "l": "GTP + NAD(+) = GDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32955", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64132", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866941", "l": "MID1IP1 binds THRSP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74470", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O <=> a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49527", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38394", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380930", "l": "Phosphorylated AMPK binds AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31884", "l": "(S)-2,3-epoxysqualene => delta-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16166", "l": "L-tryptophan + O2 => CO2 + H2O + indole-3-acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61364", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.110", "l": "\"ureidoacrylate amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033455", "l": "GCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41948", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.103", "l": "\"[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15942", "l": "H2O + N(2)-acetyl-L-ornithine => acetate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388814", "l": "Grb2 binds CD28 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69887", "l": "Na(+)(out) + uridine(out) = Na(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45349", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55823", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38738", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662608", "l": "MT2A binds cadmium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63275", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57091", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26382", "l": "4-hydroxybutanoate + NADP(+) => H(+) + NADPH + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73145", "l": "CoA(in) + FAD(out) => CoA(out) + FAD(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40879", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50118", "l": "CoA + H(+) + N-eicosanoyl-taurine => eicosanoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22304", "l": "a ubiquinone + keto-D-fructose = 5-dehydro-D-fructose + a ubiquinol", "d": [], "t": []}, {"i": "EC:1.1.5.14", "l": "\"fructose 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27778", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) = 2-all-trans-octaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034780", "l": "glyphosate dehydrogenase activity", "d": ["Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24158", "l": "2-methylpropanoyl phosphate + ADP => 2-methylpropanoate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13074", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706308", "l": "Active FLT3 binds to GRB10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663174", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PER1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102818", "l": "lycopene cleavage oxygenase activity", "d": ["Catalysis of the reaction: lycopene + 2 O2 = 2 sulcatone + bixin aldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64389", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate => 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65025", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) => dehydrocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28809", "l": "L-cysteinylglycine + L-glutamate => glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724290", "l": "GNRHR2 binds GNRH1,2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28654", "l": "inosine + O2 <=> 9-riburonosylhypoxanthine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902379", "l": "chemoattractant activity involved in axon guidance", "d": ["Any chemoattractant activity that is involved in axon guidance."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794523", "l": "SLC22A1 transports Cipro into renal cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57483", "l": "2-hydroxydodecanoate + H2O2 <=> 2,3-dihydroxydodecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45668", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25804", "l": "H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30444", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72672", "l": "The 60S subunit joins the translation initiation complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.27", "l": "\"4-aminobenzoate 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23821", "l": "GDP-alpha-D-mannose => GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54980", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30281", "l": "3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.21", "l": "\"aspartate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005105", "l": "type 1 fibroblast growth factor receptor binding", "d": ["Binding to a type 1 fibroblast growth factor receptor (FGFR1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56500", "l": "(R)-3,5-bisphosphomevalonate + H(+) = CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.110", "l": "\"bisphosphomevalonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59862", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222376", "l": "NOX2 generates superoxide from oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674529", "l": "AAMP binds to TBXA2R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10902", "l": "an aromatic oxo-acid + glycine => an aromatic L-alpha-amino acid + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74797", "l": "N-methyl-(R)-salsolinol(out) => N-methyl-(R)-salsolinol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675417", "l": "PEBP1 binds activated RAF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64784", "l": "S-ethyl-L-cysteine = 2-aminoprop-2-enoate + ethanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.125", "l": "\"sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16709", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": [], "t": []}, {"i": "EC:1.14.16.4", "l": "\"tryptophan 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102532", "l": "genkwanin 6-hydroxylase activity", "d": ["Catalysis of the reaction: genkwanin + O2 + NADPH + H+ = scutellarein 7-methyl ether + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36442", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30253", "l": "2 a ubiquinone + n H(+)(out) + 2 H2O => 2 a ubiquinol + n H(+)(in) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33653", "l": "(9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate => (9Z,12Z)-octadecadienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774168", "l": "CDH19 gene expression is stimulated by ZC3H12A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757456", "l": "2,5-DHBA translocates from ER lumen to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31109", "l": "(2-hydroxyphenyl)acetate + CO2 => 3-phenylpyruvate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17363", "l": "H(+) + malonate + urea => 3-oxo-3-ureidopropanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42943", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675834", "l": "PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33581", "l": "H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68095", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA <=> a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77619", "l": "2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396009", "l": "STING binds c-di-GMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210881", "l": "Dimerization of Tie2/Ang1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948034", "l": "FGR binds LDL:LRP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41185", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67607", "l": "H2O + N(6)-methyl-dATP <=> diphosphate + H(+) + N(6)-methyl-dAMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901640", "l": "XTP binding", "d": ["Binding to XTP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38777", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64316", "l": "2 dihydrogeodin + 2 H(+) + O2 = 2 (+)-geodin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59678", "l": "D-maltotetraono-1,5-lactone + H2O2 => D-maltotetraose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27797", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66670", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56912", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) = (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17281", "l": "(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine", "d": [], "t": []}, {"i": "EC:4.2.1.108", "l": "\"ectoine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093327", "l": "EPHA binds TIAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28717", "l": "(R)-malate(out) + 2 H(+)(out) => (R)-malate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691621", "l": "C5 binds C5 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69767", "l": "(E)-non-2-enal + H2O + NAD(+) = (E)-non-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71462", "l": "H2O + substance P <=> L-Leu-L-Met-NH2 + substance P(1-9)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61867", "l": "AH2 + dehydroprobetaenone I <=> A + probetaenone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070281", "l": "pyridoxamine binding", "d": ["Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34369", "l": "acrylate + NH4(+) => acrylamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22970", "l": "butanoyl-CoA + H(+) + NADH => butanal + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0001648", "l": "proteinase-activated receptor activity", "d": ["A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939201", "l": "ESR dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19168", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102080", "l": "phenylacetyl-coenzyme A:glycine N-acyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + glycine = H+ + phenylacetylglycine + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74101", "l": "ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10960", "l": "(S)-lactate = (R)-lactate", "d": [], "t": []}, {"i": "EC:5.1.2.1", "l": "\"lactate racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51597", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982810", "l": "JAK2 phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38871", "l": "uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.20", "l": "\"23S rRNA pseudouridine(2457) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.58909006025462", "identifiers": [{"i": "GO:0050839", "l": "cell adhesion molecule binding", "d": ["Binding to a cell adhesion molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43148", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.218", "l": "\"tRNA (adenine(9)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71711", "l": "H(+)(out) + L-tyrosylglycine(out) = H(+)(in) + L-tyrosylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15854", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) => 17alpha-hydroxyprogesterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811427", "l": "COPI vesicle uncoating at the ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848395", "l": "IL18:IL18R1 binds IL18RAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36525", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44333", "l": "ATP + L-alanine + L-anticapsin => ADP + bacilysin + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43832", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45896", "l": "an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682983", "l": "ATM phosphorylates WHSC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674542", "l": "p-Y-STAT1,3,5 dimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38229", "l": "CoA + hexadecanyl (9Z)-octadecenoate => (9Z)-octadecenoyl-CoA + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45064", "l": "H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47929", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) => (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.109", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17935", "l": "a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 7-hydroxyisoflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13079", "l": "a carboxylate + D-hexose phosphate + H(+) => an acyl phosphate + D-hexose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74104", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193641", "l": "IKK-beta is recruited (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57032", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O = CO2 + formate + methylamine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050098", "l": "methylguanidinase activity", "d": ["Catalysis of the reaction: H2O + methylguanidine = methylammonium + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57471", "l": "(E)-ferulate + UDP-alpha-D-glucose <=> 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30048", "l": "chloroacetaldehyde + H2O + NAD(+) => chloroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36495", "l": "alpha-D-glucose + ATP = ADP + alpha-D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69383", "l": "2-hydroxy-4-methylpentanoate + O2 <=> 4-methyl-2-oxopentanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75864", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047691", "l": "aspulvinone dimethylallyltransferase activity", "d": ["Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070551", "l": "endoribonuclease activity, cleaving siRNA-paired mRNA", "d": ["Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419334", "l": "Melatonin receptors can bind melatonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14262", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone => 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35518", "l": "4'''-demalonylsalvianin + malonyl-CoA <=> CoA + salvianin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.-.-.-", "l": "\"Translocases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53517", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375131", "l": "Basigin binds CD98 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213201", "l": "Formation of collagen fibres (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64628", "l": "acetyl-CoA + octan-1-ol = CoA + octyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59794", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + yersinopine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63390", "l": "2 AH2 + Fe(II)-heme a => 2 A + Fe(II)-heme o + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58871", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66533", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451033", "l": "(S)-Malate <=> Fumarate + H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63466", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP => (2E,6E,10E)-geranylgeraniol + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54143", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56467", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65346", "l": "(2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102710", "l": "D-inositol-3-phosphate glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36507", "l": "docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32173", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34238", "l": "4-nitro-6-oxohepta-2,4-dienedioate <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65365", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0016668", "l": "oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}, {"i": "EC:1.8.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18545", "l": "2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.18", "l": "\"2-dehydro-3-deoxy-L-pentonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004630", "l": "phospholipase D activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791124", "l": "Expression of DNAJB9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56533", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72068", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate => ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57406", "l": "H(+) + NADH + noscapine => NAD(+) + narcotine hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047031", "l": "diethyl 2-methyl-3-oxosuccinate reductase activity", "d": ["Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578712", "l": "Importin-8 binds AGO2:miRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30106", "l": "2,5-didehydro-D-gluconate + H(+) + NADH <=> 5-dehydro-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50766", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451418", "l": "Pellino ubiquitinates IRAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68703", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72883", "l": "2 3-phenylpyruvate + 2 ATP = 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76977", "l": "(9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39447", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592241", "l": "Expression of SSBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54389", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433454", "l": "Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20850", "l": "acetyl phosphate + CO2 + H2O2 => H(+) + O2 + phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34981", "l": "H(+)(out) => H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15763", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH => L-homoserine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818010", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70439", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30032", "l": "(S)-muconolactone => cis,cis-muconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43616", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.80", "l": "\"molybdopterin-synthase adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34650", "l": "S-adenosyl-L-methionine + squalene <=> 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807585", "l": "BPI binds LPS on the bacterial surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604752", "l": "Initial activation of proMMP13 by MMP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44156", "l": "1D-myo-inositol 5-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018743", "l": "phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10480", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate = 4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62023", "l": "H2O + sitosteryl 3-beta-D-glucoside <=> D-glucose + sitosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047838", "l": "D-xylose 1-dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47964", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005534", "l": "galactose binding", "d": ["Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75315", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) = chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22058", "l": "H(+) + hexadecanal + NADH => hexadecan-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10318", "l": "5-hydroxymethyluracil + CO2 + succinate => 2-oxoglutarate + O2 + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69319", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> allyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.5", "l": "\"NAD(+) glycohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63432", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11332", "l": "ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": [], "t": []}, {"i": "EC:2.7.7.19", "l": "\"polynucleotide adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42130", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64396", "l": "glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210646", "l": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62182", "l": "diphosphate + viteagnusin D => H2O + peregrinol diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8960973", "l": "RLBP1:11cRAL dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.31", "l": "\"NAD(+)--protein-arginine ADP-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183055", "l": "Binding of CBL to EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38656", "l": "6-tuliposide B => D-glucose + tulipalin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22315", "l": "5-(methylsulfanyl)-D-ribose + ATP <=> ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390663", "l": "ADRA2A,B,C bind ADR,NAd (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35103", "l": "fusidate(in) = fusidate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375384", "l": "Bombesin-like receptors bind bombesin homologues (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042609", "l": "CD4 receptor binding", "d": ["Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102910", "l": "dirigent protein activity", "d": ["Catalysis of the reaction: 2 H+ + 2 coniferol + O2 = (+)-pinoresinol + 2 H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58353", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51348", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine = 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41303", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21301", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30926", "l": "(R)-glycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41561", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 => (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30953", "l": "alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76914", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NAD(+) <=> 3-methylcyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009309", "l": "RUNX2 binds STUB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44359", "l": "nogalaviketone <=> methyl nogalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58222", "l": "H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide => L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31768", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77545", "l": "1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13282", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) => 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14652", "l": "demethyllactenocin + dTDP-beta-L-mycarose <=> demethylmacrocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19813", "l": "a 2-oxocarboxylate + L-asparagine = 2-oxosuccinamate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65235", "l": "3-hydroxydodecanoyl-CoA + H2O <=> 3-hydroxydodecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.143", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17307", "l": "dimethylamine + L-citrulline => H2O + N(omega),N(omega)-dimethyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63529", "l": "[thioredoxin]-dithiol + H2O2 => [thioredoxin]-disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15872", "l": "2-oxoglutarate + D-alanine <=> D-glutamate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707683", "l": "PGRMC2 binds Hemes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692241", "l": "Expression of SRY in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12532", "l": "coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane", "d": [], "t": []}, {"i": "EC:2.8.4.1", "l": "\"coenzyme-B sulfoethylthiotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72098", "l": "(S)-carnitine(out) + Na(+)(out) <=> (S)-carnitine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781899", "l": "USP13 binds SIAH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160147", "l": "tRNA pseudouridine(38-40) synthase activity", "d": ["Catalysis of the reaction: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34429", "l": "(-)-pinoresinol + H(+) + NADPH => (-)-lariciresinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55487", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18370", "l": "O2 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75666", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate <=> 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68304", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] = 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.77", "l": "\"protein-L-isoaspartate(D-aspartate) O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634418", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate <=> 7,8-dihydropteroate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24902", "l": "3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.52", "l": "\"cyclic-guanylate-specific phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33614", "l": "H2O + methyl salicylate <=> H(+) + methanol + salicylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28052", "l": "NAD(+) + phosphate => H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22481", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60268", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801213", "l": "TP53 stimulates TRIAP1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9833973", "l": "ISGylation of PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54537", "l": "a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19988", "l": "NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58120", "l": "ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22251", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) <=> 7,8-dihydroxykynurenate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904713", "l": "beta-catenin destruction complex binding", "d": ["Binding to a beta-catenin destruction complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204873", "l": "Interaction of Tie2 and Shp2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12651", "l": "H(+) + L-rhamnono-1,4-lactone + NADH => L-rhamnofuranose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50807", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183051", "l": "CBL ubiquitinates Sprouty (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944236", "l": "Association of procollagen type XIV (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63057", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48231", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] <=> a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57172", "l": "(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004107", "l": "chorismate synthase activity", "d": ["Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389381", "l": "Gads binds CD28 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879674", "l": "CD97 binds CD55 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507719", "l": "p62:MEKK3 binds to TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10699", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] <=> AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67286", "l": "(1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729279", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53910", "l": "CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-butenoyl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25791", "l": "4-hydroxy-2-oxoheptanedioate <=> pyruvate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191784", "l": "snRNA Cap hypermethylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794008", "l": "LUBAC binds CFLAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202722", "l": "CD48 binds CD244 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39803", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982765", "l": "Growth hormone forms dimers and oligomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74417", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.35", "l": "\"2-dehydrotetronate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59776", "l": "D-arabinitol + O2 = D-arabinose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11967", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218804", "l": "p38 MAPK activation by VEGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24437", "l": "H2 + methanophenazine => dihydromethanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0086080", "l": "protein binding involved in heterotypic cell-cell adhesion", "d": ["Binding to a protein or protein complex contributing to the adhesion of two different types of cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021182", "l": "MECP2 mRNA binds miR-132 RISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019702", "l": "protein arginine N5-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51331", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13997", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) = 2-methylpropanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0034584", "l": "piRNA binding", "d": ["Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59365", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27492", "l": "2 D-sedoheptulose 7-phosphate <=> D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690023", "l": "NUBPL binds 4Fe-4S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14659", "l": "D-ribulose 5-phosphate => aldehydo-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43501", "l": "beta-D-glucuronate + NAD(+) => D-glucaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452097", "l": "Recruited STAT5 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008269", "l": "JAK pathway signal transduction adaptor activity", "d": ["The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25547", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-9(11),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25055", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72626", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base <=> a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76076", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) => a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71634", "l": "phosphate(in) + sulfate(out) <=> phosphate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62170", "l": "acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804253", "l": "MDM2 ubiquitinates JMY (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55821", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53395", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] <=> (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031527", "l": "Expression of APOC2 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28208", "l": "ADP + dUMP + H(+) => 2'-deoxyuridine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75226", "l": "H2O + L-fucono-1,4-lactone <=> H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018556", "l": "2,2',3-trihydroxybiphenyl dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49067", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75414", "l": "demethyllactenocin + S-adenosyl-L-methionine <=> H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.119", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24563", "l": "acetyl-CoA + L-serine <=> CoA + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34491", "l": "H2O + UDP-N,N'-diacetylbacillosamine = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805126", "l": "AURKB phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612219", "l": "ERBB4s80 binds to SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647994", "l": "RAS proteins are depalmitoylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102330", "l": "palmitoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982645", "l": "GRKs bind ADRB2:Catecholamine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20820", "l": "choline sulfate + H2O = choline + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.6", "l": "\"choline-sulfatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14771", "l": "(S)-6-hydroxynicotine + AH2 => (S)-nicotine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16959", "l": "GMP + H(+) => 3',5'-cyclic GMP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57369", "l": "H2O + NADPH => (6R)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804035", "l": "N2O3 diffuses to phagosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21863", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27752", "l": "2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 2'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951727", "l": "cAMP binds PKA tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682863", "l": "RNF168 binds DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452097", "l": "Recruited STAT5 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35926", "l": "neamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10462", "l": "prostaglandin C1 => prostaglandin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33499", "l": "H(+) + prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.100", "l": "\"prephenate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015411", "l": "ABC-type taurine transporter transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32487", "l": "CDP-choline + H2O = CMP + 2 H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59261", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16151", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53447", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30882", "l": "H2O + NAD(+) + prop-2-ynal <=> 2 H(+) + NADH + propynoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43868", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29176", "l": "2 O2 + ubiquinol-8 => 2 H(+) + 2 superoxide + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0004774", "l": "succinate-CoA ligase activity", "d": ["Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25674", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.78", "l": "\"phosphatidylinositol-4,5-bisphosphate 4-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568846", "l": "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462005", "l": "pro-defensin alpha 5 is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2172433", "l": "Collagen type XIX degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013435", "l": "RHOD auto-activates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249378", "l": "STING recruits TBK1 and STAT6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630043", "l": "Defective NTHL1 truncation mutants do not bind thymine glycol (Tg) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15513", "l": "ATP + keto-D-tagatose = ADP + H(+) + keto-D-tagatose 6-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.101", "l": "\"tagatose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051994", "l": "P-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390886", "l": "HRH4 binds Hist (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247511", "l": "STAB2:ligand is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41955", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19272", "l": "2-furoate + ATP + CoA <=> 2-furoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392195", "l": "Gi activation by P2Y purinoceptor 12 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75234", "l": "H2O + L-galactono-1,4-lactone <=> H(+) + L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55509", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52525", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59250", "l": "(E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57037", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700149", "l": "Active ALK binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58856", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-oxogeraniol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35582", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 <=> anthocyanin A11 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949580", "l": "F1Fo ATP synthase dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52250", "l": "12 H(+) + 4 MnO2 => 6 H2O + 4 Mn(3+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.27", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36307", "l": "(E)-caffeoyl-CoA + H2O = 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139899", "l": "Sequestration of BAD protein by 14-3-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24929", "l": "NH4(+) + pyruvate + S-sulfanyl-L-cysteine => H2O + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856945", "l": "PP2A methylation by LCMT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008503", "l": "benzodiazepine receptor activity", "d": ["Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15914", "l": "ATP + thiamine phosphate => ADP + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015667", "l": "site-specific DNA-methyltransferase (cytosine-N4-specific) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68661", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76313", "l": "L-aspartate(out) + L-glutamine(in) => L-aspartate(in) + L-glutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31703", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30400", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708292", "l": "DICER1 cleaves tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39633", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785684", "l": "Fibronectin degradation by CTSG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.57", "l": "\"diamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990312", "l": "type-II cohesin domain binding", "d": ["Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50379", "l": "a ceramide(in) + ATP + H2O <=> a ceramide(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65098", "l": "a 1-hexadecanoyl-2-acylglycerol + CoA => a 2-acylglycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948536", "l": "PTENP1 mRNA binds miR-20 RISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34296", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51106", "l": "13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30379", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.78", "l": "\"beta-chamigrene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23934", "l": "an N-acyl-D-mannosamine 6-phosphate => an N-acyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669012", "l": "EDA binds EDAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38197", "l": "estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390425", "l": "FAR1 reduces PalmCoA to HXOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218805", "l": "PKC autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35648", "l": "ATP + GTP => 3',3'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253343", "l": "WWOX binds ERBB4s80 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981606", "l": "Myoglobin binds oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47243", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033876", "l": "glycochenodeoxycholate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938913", "l": "RUNX1 binds ELF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63828", "l": "L-alanine + vanillin = pyruvate + vanillylamine", "d": [], "t": []}, {"i": "EC:2.6.1.119", "l": "\"vanillin aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12135", "l": "ATP + Cd(2+)(in) + H2O <=> ADP + Cd(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77233", "l": "(S)-2-hydroxypropylphosphonate + CMP + H(+) => cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050632", "l": "propionyl-CoA C2-trimethyltridecanoyltransferase activity", "d": ["Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48641", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) => 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102993", "l": "linolenate delta15 desaturase activity", "d": ["Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor = 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23179", "l": "acetate + ATP + CoA <=> acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13090", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) => 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56518", "l": "2 CO2 + 4 H2O + heme b => Fe-coproporphyrin III + 2 H(+) + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341048", "l": "SUMOylation of RXRA with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951486", "l": "CD46 binds C4b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13803", "l": "4 H(+) + 3 NADPH + sulfite => 3 H2O + hydrogen sulfide + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848110", "l": "SOCS3 binds activated PTK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936851", "l": "AHRR binds ARNT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23628", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.65", "l": "\"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17821", "l": "hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": [], "t": []}, {"i": "EC:4.4.1.9", "l": "\"L-3-cyanoalanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33954", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine <=> 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734475", "l": "PPARA binds fibrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11723", "l": "ATP + 2 H2O + N-methylhydantoin <=> ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71763", "l": "2-oxoglutarate(out) + citrate(in) = 2-oxoglutarate(in) + citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69436", "l": "7-oxopregnenolone + H(+) + NADPH = 7beta-hydroxypregnenolone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24601", "l": "H2O + O2 + sulfite => H2O2 + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042131", "l": "thiamine phosphate phosphatase activity", "d": ["Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.37", "l": "\"aldose-1-phosphate nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004651", "l": "polynucleotide 5'-phosphatase activity", "d": ["Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54408", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18514", "l": "D-mannitol + O2 => D-mannose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.254", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatB\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74716", "l": "Insulin binds the insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964759", "l": "Alternative endo-mannosidase I route (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28284", "l": "(S)-beta-macrocarpene => (S)-beta-bisabolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44280", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16764", "l": "chlorohydroquinone + O2 <=> 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15380", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP <=> (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70301", "l": "2,3-dioxo-L-gulonate => H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19292", "l": "H2O + sucrose 6(F)-phosphate <=> phosphate + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399939", "l": "Autophosphorylation of PAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58316", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674018", "l": "BRAP binds RAS:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010309", "l": "acireductone dioxygenase [iron(II)-requiring] activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659611", "l": "ANO1 inhibitors bind ANO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58036", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = 8-epi-inunolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814764", "l": "Plasma membrane resorption (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446077", "l": "BP230 interacts with keretin K5/K14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31928", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61716", "l": "ATP + D-galactofuranose(out) + H2O = ADP + D-galactofuranose(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.5.2.9", "l": "\"ABC-type D-galactofuranose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30442", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679029", "l": "C-ter TLR7 dimer binds HCQ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43026", "l": "2-aminoprop-2-enoate + a thiol => an S-substituted L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57569", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55429", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33576", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose => a mannosylinositol-1-phosphophytoceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109858", "l": "MAP2K2 binds MAPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28251", "l": "acetyl-CoA + H(+) + malonyl-CoA => acetoacetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60049", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74687", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.1.8", "l": "\"N-(sulfonatooxy)prop-2-enimidothioate sulfolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17898", "l": "A + ethylbenzene + H2O => (S)-1-phenylethanol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615348", "l": "AGT(34-41) binds to AGTR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55184", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 = 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196026", "l": "Dab2 is recruited to the junctional plaques (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35309", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004972", "l": "NMDA glutamate receptor activity", "d": ["An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684140", "l": "ATM phosphorylates RBBP8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75345", "l": "adenosine(out) => adenosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395340", "l": "Formation of hydroxyallysine by LOX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75970", "l": "(6-hydroxyhexanoyl)n + H2O <=> (6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44645", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24385", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine => AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76082", "l": "a dicarboxylate(in) + L-sepiapterin(out) <=> a dicarboxylate(out) + L-sepiapterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55386", "l": "6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22827", "l": "2'-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16071", "l": "NH4(+) + uridine => cytidine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38328", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44622", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216045", "l": "Collagen type I binds integrin alpha11beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12271", "l": "2-oxoglutarate + putrescine <=> 1-pyrroline + H2O + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32039", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27523", "l": "2,5-dihydroxypyridine + O2 => H(+) + N-formylmaleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950684", "l": "Expression of Heterogeneous nuclear ribonucleoprotein D-like (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534365", "l": "Slo3 Potassium Transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69053", "l": "RFC binding displaces Pol Alpha (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67316", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67954", "l": "an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24510", "l": "H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430135", "l": "p-SLP-76 binds ADAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008924", "l": "malate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102431", "l": "acyl-lipid omega-(9-4) desaturase activity", "d": ["Catalysis of the reaction: a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid) and add a fourth double bond (a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673797", "l": "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36443", "l": "dihydrochanoclavine-I aldehyde = 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58266", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53050", "l": "2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390649", "l": "CHRM1,3,5 bind acetylcholine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183052", "l": "CBL binds to GRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68682", "l": "3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018774", "l": "RHOBTB1 binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60506", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14816", "l": "L-2-aminohexano-6-lactam <=> D-2-aminohexano-6-lactam", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825555", "l": "RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61193", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11295", "l": "2 H(+) + O2 + rifamycin B <=> H2O2 + rifamycin O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45646", "l": "H(+) + N-hexadecanoylsphing-4-enine + phosphocholine => H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75329", "l": "chloride(in) + D-tryptophan(in) + 2 Na(+)(in) => chloride(out) + D-tryptophan(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12807", "l": "(S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine => (S)-canadine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061923", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59350", "l": "D-maltobionate + H(+) => D-maltobiono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0046812", "l": "host cell surface binding", "d": ["Binding to the surface of a host cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849428", "l": "PTPN1 binds PTK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76580", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADPH => (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0015631", "l": "tubulin binding", "d": ["Binding to monomeric or multimeric forms of tubulin, including microtubules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16327", "l": "diphosphate + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314569", "l": "GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093332", "l": "p-EPHB phosphorylates SDC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045302", "l": "choloylglycine hydrolase activity", "d": ["Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788061", "l": "Fibronectin degradation by ADAM8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014454", "l": "RHOG translocates to the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102809", "l": "delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside = H+ + delphinidin 3-O-sophoroside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046180", "l": "KSPG is secreted from the cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038021", "l": "leptin receptor activity", "d": ["Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73356", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine => carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018484", "l": "4-hydroxybenzaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111970", "l": "PKC phosphorylates GRK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57502", "l": "2-methyl-cis-aconitate + H2O => 3-hydroxybutane-1,2,3-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976723", "l": "Serum amyloid P-component forms homopentamers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67054", "l": "A + asnovolin A + H2O => AH2 + asnovolin J + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170149", "l": "Translocation of active Cdc25C to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395236", "l": "TP53 binds promoters of MIR34 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682769", "l": "LGI2 binds ADAM22,23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.348834789597348", "identifiers": [{"i": "GO:0101005", "l": "deubiquitinase activity", "d": ["An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."], "t": []}, {"i": "REACT:R-HSA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789960", "l": "Expression of NDN,TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70555", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022876", "l": "protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53998", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174171", "l": "Association of Cyclin A with the APC/C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008108", "l": "UDP-glucose:hexose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801195", "l": "STEAP3 binds BNIP3L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351208", "l": "Spermidine  => N-acetylated spermidine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17411", "l": "(S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-coclaurine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026464", "l": "BDNF-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610723", "l": "GLI proteins bind SUFU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57648", "l": "S-adenosyl-L-methionine + trichosetin = equisetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49952", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate = 5,10-dihydrophenazine 1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866269", "l": "ARRB bind GPCRs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088134", "l": "PLK1 phosphorylates FOXM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19570", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine => 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43765", "l": "ATP + chenodeoxycholate + CoA => AMP + chenodeoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.-", "l": "\"Nucleotidyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917700", "l": "MVB Vesicle Formation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032034", "l": "myosin II head/neck binding", "d": ["Binding to the head/neck region of a myosin II heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102171", "l": "DMNT synthase activity", "d": ["Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 = (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47219", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37053", "l": "ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870469", "l": "RGGT geranylgeranylates RAB proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31111", "l": "acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69364", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA = CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": [], "t": []}, {"i": "EC:2.3.1.307", "l": "\"6-diazo-5-oxo-L-norleucine N(alpha)-acetyltranferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55902", "l": "6-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201443", "l": "Type II receptor phosphorylates type I receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10286", "l": "(3R)-beta-leucine => L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62268", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14785", "l": "RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": [], "t": []}, {"i": "EC:2.7.7.52", "l": "\"RNA uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481044", "l": "Surface deployment of platelet alpha granule membrane components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60332", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6795667", "l": "MDM2 translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41842", "l": "(3R)-hydroxyoctanoyl-[ACP] + NADP(+) => 3-oxooctanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25309", "l": "7,8-dihydroneopterin + phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481010", "l": "Surface deployment of platelet dense granule membrane components (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009378", "l": "four-way junction helicase activity", "d": ["Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953037", "l": "E2F8 forms homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987120", "l": "JAK1 binds IFNLR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74774", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001039", "l": "RNA polymerase III hybrid type promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928591", "l": "EPH:EFN tetramers oligomerise (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835121", "l": "Heparin binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61632", "l": "5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.2", "l": "\"NAD(P)(+) transhydrogenase (Re/Si-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12447", "l": "hexadecanal + NADP(+) <=> (2E)-hexadecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73483", "l": "D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28521", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29587", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.312", "l": "\"2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138459", "l": "WNT5A:FZD4 is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11857", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799418", "l": "TP53 binds the TP53INP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75348", "l": "thiocyanate(in) => thiocyanate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11533", "l": "glycine + H2O + O2 => glyoxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052598", "l": "histamine oxidase activity", "d": ["Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36457", "l": "ADP + H(+) + L-alanylglycine(in) + phosphate => ATP + H2O + L-alanylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30777", "l": "H2O2 + NH4(+) + pyridoxal => H2O + O2 + pyridoxamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791084", "l": "Expression of SYVN1 (HRD1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848110", "l": "SOCS3 binds activated PTK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202459", "l": "Phosphorylation of Bcl10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942075", "l": "Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35059", "l": "chloramphenicol(in) + H(+)(out) = chloramphenicol(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42314", "l": "NADPH + 2 oxidized [adrenodoxin] => H(+) + NADP(+) + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30819", "l": "allantoin + H2O = allantoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013009", "l": "RHOA binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55471", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202137", "l": "AKT1 binds eNOS complex via HSP90 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448741", "l": "IL22RA2 binds IL22 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660663", "l": "Caspase-8 cleaves IL1B precursor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674427", "l": "PDGFR mutants bind type I TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879222", "l": "MDP:NLRP1 binds ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2301205", "l": "SETD8 monomethylates histone H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24460", "l": "H(+) + malonyl-[ACP] = acetyl-[ACP] + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.87", "l": "\"malonyl-[malonate decarboxylase] decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070410", "l": "co-SMAD binding", "d": ["Binding to a common mediator SMAD signaling protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382054", "l": "PDGF binds to extracellular matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851298", "l": "GPR143 binds L-Dopa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867613", "l": "PICALM binds R-SNAREs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433418", "l": "Phosphorylation of JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693575", "l": "DNA-PKcs autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29979", "l": "2'-deoxyadenosine(in) + H(+)(in) = 2'-deoxyadenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10330", "l": "a 2-hydroxycarbonyl + H(+) + NADH => an L-glycol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72672", "l": "The 60S subunit joins the translation initiation complex  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848726", "l": "PTK6 phosphorylates BCAR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265301", "l": "Corticotropin cleavage from POMC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28919", "l": "4-aminobutanoate(in) + L-glutamate(out) = 4-aminobutanoate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46586", "l": "1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31420", "l": "(2Z,6E)-farnesyl diphosphate => (-)-beta-curcumene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800035", "l": "IGFBP3 binds TMEM219 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018611", "l": "toluate dioxygenase activity", "d": ["Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097008", "l": "(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity", "d": ["Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793400", "l": "NOTCH1 coactivator complex binds the TBX6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60058", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+) => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2870221", "l": "E-selectin binds E-selectin ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23001", "l": "(R)-pantoate + NAD(+) => (R)-4-dehydropantoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68479", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) <=> a fatty aldehyde + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189062", "l": "lactose + H2O => D-glucose + D-galactose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45363", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine <=> (11Z)-eicosenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64967", "l": "dUTP + 2 H2O <=> dUMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609860", "l": "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44418", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008158", "l": "hedgehog receptor activity", "d": ["Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70146", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49900", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 = H2O2 + phenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050631", "l": "corydaline synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51601", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445714", "l": "Aquaporin-3 passively transports water out of cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36203", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31025", "l": "dammara-20,24-diene => squalene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47537", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isochenodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16887", "l": "bilirubin IXalpha + bilirubin-bisglucuronoside => 2 bilirubin-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77094", "l": "Formation of cap binding complex (CBC) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32784", "l": "ATP + glycine betaine(out) + H2O => ADP + glycine betaine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56075", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose <=> a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59144", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465926", "l": "An atROL isomerase isomerises atROL to 11cROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73592", "l": "CTP(out) + dUTP(in) => CTP(in) + dUTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16400", "l": "2 D-glucopyranose 1-phosphate <=> D-glucose + D-glucose 1,6-bisphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624956", "l": "PDE6D binds INPP5E (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22181", "l": "(S)-norreticuline + S-adenosyl-L-methionine => (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483174", "l": "PE is methylated to PC by PEMT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54401", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015142", "l": "tricarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69831", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869568", "l": "NPM1 binds TFAP2A homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008786", "l": "allose 6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748996", "l": "GST dimers cleave AZA to 6MP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103057", "l": "gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate = H+ + gibberellin A20 + 2 carbon dioxide + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16029", "l": "3-guanidinopropanoate + H2O = beta-alanine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18739", "l": "AMP + 2 H(+) + phosphate + selenophosphate => ATP + H2O + hydrogenselenide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49051", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44768", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) = 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67061", "l": "asnovolin I + S-adenosyl-L-methionine => asnovolin K + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609728", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3B (GRIN3B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700168", "l": "Active ALK phosphorylates IRS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24191", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) <=> 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33519", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine = (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25312", "l": "glycolate + O2 => glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49145", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60792", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 = 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28197", "l": "(2S)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735276", "l": "Expression of HAND1 in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047688", "l": "aspartate 4-decarboxylase activity", "d": ["Catalysis of the reaction: L-aspartate = L-alanine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835358", "l": "p-TARBP2 binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63878", "l": "(4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11620", "l": "H2O + L-2-amino-4-chloropent-4-enoate = 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": [], "t": []}, {"i": "EC:4.5.1.4", "l": "\"L-2-amino-4-chloropent-4-enoate dehydrochlorinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879937", "l": "The common beta chain IL3RB binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11079", "l": "anthranilate + 3 H(+) + NADH + O2 <=> catechol + CO2 + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72808", "l": "L-histidine(out) => L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43885", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39804", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67729", "l": "DNA(n) + dZTP => diphosphate + DNA(n)-Z", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45526", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29970", "l": "2'-deoxyuridine(in) + H(+)(in) <=> 2'-deoxyuridine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15908", "l": "3-hydroxycyclohexanone + A <=> AH2 + cyclohexane-1,3-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707690", "l": "BACH1 binds MAFK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015452", "l": "methyl transfer-driven active transmembrane transporter activity", "d": ["Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source."], "t": []}, {"i": "TCDB:3.C", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70889", "l": "L-glutamine(out) + L-serine(in) + Na(+)(in) => L-glutamine(in) + L-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11638", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => NADP(+) + prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72074", "l": "L-histidyl-[protein] + NAD(+) <=> H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49844", "l": "(-)-dehydrodiconiferyl acid + a quinone = (-)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210271", "l": "Interaction of DAP12 and MDL-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399952", "l": "Phosphorylation of LIMK-1 by PAK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15871", "l": "D-glutamate + pyruvate => 2-oxoglutarate + D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417842", "l": "P2Y10 receptor can bind to LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20635", "l": "a lyso-ornithine lipid + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73735", "l": "O2 + trans-resveratrol = 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68549", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22804", "l": "(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.221", "l": "\"vomifoliol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611030", "l": "GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11965", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69624", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052773", "l": "diacetylchitobiose deacetylase activity", "d": ["Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56621", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381109", "l": "IRE1 binds IRE1 forming dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634834", "l": "ACHEIs bind ACHE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23804", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:5.4.2.3", "l": "\"phosphoacetylglucosamine mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62357", "l": "8-oxo-GDP + H2O => 8-oxo-GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250217", "l": "ARL2:GTP binds ARL2BP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47866", "l": "dioctanoylglycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15486", "l": "(2R,3S)-homoisocitrate => cis-homoaconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20299", "l": "a carboxylate + aniline + H(+) => an anilide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875443", "l": "USP8 deubiquitinates LRIG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29194", "l": "L-aspartate + menaquinone-8 <=> iminosuccinate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218805", "l": "PKC autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26436", "l": "H2O + L-tryptophan => indole + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717841", "l": "holo-FDPS dimer binds NBPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9736953", "l": "FURIN translocates to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75680", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47170", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34872", "l": "methanol(out) => methanol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694462", "l": "ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15762", "l": "L-homoserine + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31398", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) <=> all-trans-4,4'-diapophytofluene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374298", "l": "Opioid receptors bind opioid peptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837179", "l": "FASTKD5 binds 12S rRNA and mitochondrial mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129375", "l": "Elastin cross-linking by lysyl oxidase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51111", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805546", "l": "Keratin type I binds keratin type II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61748", "l": "rubusoside + UDP-alpha-D-glucose = H(+) + stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170986", "l": "Ral-GDS binds to Ras-GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.59", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032041", "l": "NAD-dependent histone H3K14 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14177", "l": "(R)-amygdalin + H2O = (R)-prunasin + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.117", "l": "\"amygdalin beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54414", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5beta-steroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58854", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-oxogeraniol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19251", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + glycine => glyoxylate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47773", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45860", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41178", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) <=> methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67631", "l": "ATP + dGMP + L-aspartate <=> (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42703", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O <=> 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40981", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72763", "l": "anthocyanin A10 + malonyl-CoA = anthocyanin A11 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76594", "l": "N,N-dimethylglycine(out) + Na(+)(out) <=> N,N-dimethylglycine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52772", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": [], "t": []}, {"i": "EC:4.1.2.60", "l": "\"dihydroneopterin triphosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76273", "l": "N,N-dimethylglycine(out) => N,N-dimethylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53632", "l": "(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.161", "l": "\"(3S)-(+)-asterisca-2(9),6-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12690", "l": "2 mycothiol + NAD(+) => H(+) + mycothione + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29794", "l": "ATP + glutathione(out) + H2O <=> ADP + glutathione(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937792", "l": "RUNX3 binds SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69834", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635853", "l": "Hh-dependent expression of GLI1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22066", "l": "ergosterol + H2O => 5alpha-ergosta-7,22-diene-3beta,5-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35089", "l": "D-glucosamine + N-acetyl-D-glucosamine 6-phosphate => H2O + N'-monoacetylchitobiose-6'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15082", "l": "acetate + ATP + CoA => acetyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28149", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37806", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29323", "l": "fumarate(in) + succinate(out) = fumarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24485", "l": "NAD(+) + sulcatol => H(+) + NADH + sulcatone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47898", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH => 6-sulfo-D-quinovose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57869", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 => (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002401", "l": "Association of procollagen type XVIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204500", "l": "CyP60 chaperones Basigin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671972", "l": "CIT binds CDKN1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660660", "l": "p300 acetylates RELA subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103055", "l": "gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 = gibberellin A24 + succinate + carbon dioxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14253", "l": "guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26277", "l": "Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.271", "l": "\"cobalt-precorrin-4 methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11909", "l": "H2O + nonane-4,6-dione => butanoate + H(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45486", "l": "acetaldehyde + CO2 => H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58312", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.54", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27580", "l": "(R)-piperazine-2-carboxylate + tert-butylamine => (R)-N-tert-butylpiperazine-2-carboxamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10806", "l": "(R)-allantoin => (S)-allantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110307", "l": "REV1 binds AP-dsDNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110219", "l": "Cleavage of thymine by TDG glycosylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10711", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198458", "l": "Efflux of Glc from the endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31966", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23681", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50923", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43100", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.211", "l": "\"tRNA(Ser) (uridine(44)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58546", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-tetradecanoylglycine + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45894", "l": "an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+) => an N-acylsphing-4-enine + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210274", "l": "SIRP beta binds TYROBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42351", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607751", "l": "TRAF6 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56132", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = a thymidine dimer in DNA", "d": [], "t": []}, {"i": "EC:4.1.99.14", "l": "\"spore photoproduct lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55709", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) => [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57964", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.168", "l": "\"germacreene A acid 8beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51166", "l": "5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39202", "l": "(3R)-hydroxytetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75172", "l": "Formation of RAD50:MRE11 complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42787", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735505", "l": "Expression of SRF in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23275", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose <=> an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018747", "l": "RHOQ GEFs activate RHOQ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16655", "l": "2-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375157", "l": "Interaction of NCAM1 with contactin-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54361", "l": "4-methyl-2-oxopentanoate + H(+) => 3-methylbutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730736", "l": "Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53243", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112385", "l": "Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34681", "l": "adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate => ATP + methylphosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24995", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63459", "l": "(2E,6E,10E)-geranylgeraniol + CTP <=> (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10436", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.106", "l": "\"bile-acid 7alpha-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36272", "l": "caffeine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333609", "l": "MeSebGalNac is hydrolysed to MeSeH and bGalNac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72575", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58075", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH <=> a jasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18681", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.5.1.7", "l": "\"UDP-N-acetylglucosamine 1-carboxyvinyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030628", "l": "pre-mRNA 3'-splice site binding", "d": ["Binding to a pre-mRNA 3' splice site sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314566", "l": "GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508451", "l": "PTK2B is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15259", "l": "acetaldehyde + glycine => D-threonine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48747", "l": "(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794569", "l": "Apical transport of Cipro to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38799", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75491", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) = 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49227", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42900", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.187", "l": "\"23S rRNA (guanine(745)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37723", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15989", "l": "(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.34", "l": "\"hydroxymethylglutaryl-CoA reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45878", "l": "6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA => 2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23069", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA => 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44761", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390438", "l": "FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856951", "l": "PP2A demethylation by PPME1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63232", "l": "(2E)-octenoyl-CoA + H(+) + NADH = NAD(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003866", "l": "3-phosphoshikimate 1-carboxyvinyltransferase activity", "d": ["Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68026", "l": "phosphate + presqualene alcohol => H2O + presqualene monophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23967", "l": "(E)-coniferaldehyde + H2O + NADP(+) <=> (E)-ferulate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781899", "l": "USP13 binds SIAH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673756", "l": "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005359", "l": "low-affinity glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229348", "l": "Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032051", "l": "clathrin light chain binding", "d": ["Binding to a clathrin light chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70046", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18049", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde", "d": [], "t": []}, {"i": "EC:2.6.1.11", "l": "\"acetylornithine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17265", "l": "trans-aconitate = cis-aconitate", "d": [], "t": []}, {"i": "EC:5.3.3.7", "l": "\"aconitate Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944632", "l": "miR-106 microRNAs bind PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51566", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864569", "l": "WWOX binds TFAP2C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008239", "l": "dipeptidyl-peptidase activity", "d": ["Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013108", "l": "GDIs block activation of RHOC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66757", "l": "ATP + domoate(in) + H2O => ADP + domoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55681", "l": "(2S)-2-amino-4-deoxychorismate => anthranilate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56162", "l": "an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP => an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62678", "l": "6-thio-IMP + 7,8-dihydrofolate + H2O => 10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008068", "l": "extracellularly glutamate-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69598", "l": "Ubiquitination of phosphorylated Cdc25A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71303", "l": "RPE dimers isomerise RU5P to XY5P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53808", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.87", "l": "\"homoisocitrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686699", "l": "Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043766", "l": "Sep-tRNA:Cys-tRNA synthase activity", "d": ["Catalysis of the reaction: H+ + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102033", "l": "long-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58660", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034932", "l": "1-methoxypyrene 6,7-monooxygenase activity", "d": ["Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37719", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56809", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] => adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74865", "l": "H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine => (R)-salsolinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374680", "l": "L1 trans-homophilic interaction (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10557", "l": "D-glyceraldehyde 3-phosphate + L-arginine => H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51444", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42252", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA = 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34390", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26310", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21780", "l": "A + cyclohexanone = AH2 + cyclohex-2-enone", "d": [], "t": []}, {"i": "EC:1.3.99.14", "l": "\"cyclohexanone dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14429", "l": "a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.6", "l": "\"ABC-type oligopeptide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-990489", "l": "Kinesin-13 is a dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66986", "l": "3-methylbutanoate + CoA + H(+) => 3-methylbutanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36314", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25520", "l": "an acyl-CoA + pseudotropine = CoA + H(+) + O-acylpseudotropine", "d": [], "t": []}, {"i": "EC:2.3.1.186", "l": "\"pseudotropine acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427336", "l": "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050514", "l": "homospermidine synthase (spermidine-specific) activity", "d": ["Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53960", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.13", "l": "\"4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38315", "l": "chorismate = 3-hydroxybenzoate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.45", "l": "\"3-hydroxybenzoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54222", "l": "all-trans-neurosporene + H2O => 1-hydroxy-all-trans-1,2-dihydro-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48479", "l": "a ganglioside GT1a (d18:1(4E)) + H2O <=> a ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637796", "l": "Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23729", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 => A + H2O + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43621", "l": "L-serine + NADP(+) => aminoacetaldehyde + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0034596", "l": "phosphatidylinositol phosphate 4-phosphatase activity", "d": ["Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015195", "l": "L-threonine transmembrane transporter activity", "d": ["Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452338", "l": "Expression of TDGF1 (CRIPTO) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.19", "l": "\"[protein ADP-ribosylarginine] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18877", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.39", "l": "\"inositol 3-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58258", "l": "ADP-D-ribose + L-seryl-[protein] => H2O + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.36", "l": "\"trihydroxypterocarpan dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11680", "l": "ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": [], "t": []}, {"i": "EC:6.3.5.2", "l": "\"GMP synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12786", "l": "an alditol + NAD(+) => an aldose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58201", "l": "2-oxoglutarate + 6-aminohexanoate => 6-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836404", "l": "p-PKR dimer phosphorylates MAPT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141341", "l": "SMOX-3 oxidises SPN to SPM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654159", "l": "Activated FGFR2 binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.427", "l": "\"D-arabinose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48237", "l": "2 2-acetylphloroglucinol => 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66035", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33036", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31326", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22794", "l": "nocardicin A => isonocardicin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022141", "l": "Prolysyl oxidase activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58563", "l": "15alpha-stemmadenine intermediate II + NADP(+) <=> 15alpha-stemmadenine intermediate I + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603801", "l": "PEX19 binds PEX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72082", "l": "3 Na(+)(out) + selenate(out) <=> 3 Na(+)(in) + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.55", "l": "\"E1 SAMP-activating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050599", "l": "deacetoxycephalosporin-C synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004838", "l": "L-tyrosine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15816", "l": "1H-imidazole + acetyl-CoA <=> CoA + N-acetylimidazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36754", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42745", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169719", "l": "Secreted CD14 binds LPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351901", "l": "Caspase-mediated cleavage of MST3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24391", "l": "phosphate + uridine <=> alpha-D-ribose 1-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51243", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37519", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29790", "l": "ATP + glutathione(in) + H2O <=> ADP + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50111", "l": "hexadecanoyl-CoA + taurine <=> CoA + H(+) + N-hexadecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41205", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63273", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033452", "l": "GUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43907", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol <=> all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62375", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687107", "l": "MAPK4,6 translocate to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21224", "l": "CDP-choline + sphing-4-enine = CMP + H(+) + sphing-4-enine-phosphocholine", "d": [], "t": []}, {"i": "EC:2.7.8.10", "l": "\"sphingosine cholinephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77068", "l": "Activation of GT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69382", "l": "4-methyl-2-oxopentanoate + H2O2 => 2-hydroxy-4-methylpentanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23135", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24459", "l": "alpha-ribazole 5'-phosphate + H2O <=> alpha-ribazole + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109813", "l": "GRB2-1 binds SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23026", "l": "[(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-beta-D-glucosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45871", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676268", "l": "Formation of the MLL4 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71303", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) = chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70019", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol = 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61575", "l": "(11Z,14Z)-eicosadienoate + O2 <=> (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66390", "l": "ADP + H(+) + phosphate + prostaglandin E2(out) => ATP + H2O + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50094", "l": "an N-fatty acyl-taurine + CoA + H(+) => a fatty acyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18754", "l": "[protein]-dithiol + NADP(+) => [protein]-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11029", "l": "ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798374", "l": "DYRK2 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003849", "l": "3-deoxy-7-phosphoheptulonate synthase activity", "d": ["Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61399", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49077", "l": "dibenzothiophene + FMNH2 + O2 => dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36523", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52980", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76302", "l": "L-aspartate(in) + L-cystine(out) <=> L-aspartate(out) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49525", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 => a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41419", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77454", "l": "hydrogen cyanide + piperonal <=> (2S)-2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22623", "l": "H(+) + L-tryptophan + O2 <=> 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435244", "l": "PECAM1 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11306", "l": "glyoxylate + urea => (S)-ureidoglycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018449", "l": "1-phenylethanol dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.2", "l": "\"ferredoxin--NADP(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76283", "l": "guanine(out) + Na(+)(out) = guanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805507", "l": "APAF1 binds AVEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67560", "l": "3'-phosphoadenylyl sulfate + taurocholate = adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65077", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72185", "l": "creatinine(out) + H(+)(in) => creatinine(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74111", "l": "H(+) + hypotaurine + NADH + O2 = H2O + NAD(+) + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37541", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29213", "l": "H(+)(in) + inosine(out) => H(+)(out) + inosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624800", "l": "CDK1 phosphorylates LBR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75488", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) => dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76788", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,10-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852013", "l": "BTNL8 binds resting T cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35042", "l": "spermidine(in) <=> spermidine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003693", "l": "P-element binding", "d": ["Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796056", "l": "NFkB binds the NFE2L2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093331", "l": "Ras:GTP binds p120-RasGAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51531", "l": "H(+) + vanillate <=> CO2 + guaiacol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37843", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60919", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35932", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38853", "l": "H2O + tetracenomycin F1 => H(+) + tetracenomycin F2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74308", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) => 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75771", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O = (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21911", "l": "NADP(+) + scytalone <=> H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.60", "l": "\"marinolic acid--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156923", "l": "Hydrolysis of eEF1A:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18745", "l": "2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.17.3.4", "l": "\"juglone 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42919", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54119", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + pseudolaratriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102029", "l": "D-lactate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770141", "l": "Formation of the Spliceosomal C* complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63768", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112727", "l": "Serine phosphorylation of STATs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008718", "l": "D-amino-acid dehydrogenase activity", "d": ["Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099038", "l": "ceramide floppase activity", "d": ["Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19537", "l": "D-mannitol 1-phosphate + H2O = D-mannitol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.22", "l": "\"mannitol-1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24840", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:4.1.99.17", "l": "\"phosphomethylpyrimidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114683", "l": "Phosphorylation of Platelet Sec-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57676", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] = 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47554", "l": "deoxycholate + glycine => glycodeoxycholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106614", "l": "Duplex miRNA is loaded into Argonaute (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58259", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] <=> ADP-D-ribose + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35247", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654163", "l": "Activated FGFR4 binds PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37903", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tryprostatin A", "d": [], "t": []}, {"i": "EC:2.1.1.293", "l": "\"6-hydroxytryprostatin B O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60005", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982017", "l": "Active G alpha (q) binds RGS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18498", "l": "L-ribulose 5-phosphate => L-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41322", "l": "(9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+) => 1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64076", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018654", "l": "2-hydroxy-phenylacetate hydroxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58755", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71780", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) => 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39770", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23546", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22490", "l": "formaldehyde + glutathione => S-(hydroxymethyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75768", "l": "(9Z)-hexadecenoate + H2O => 10-hydroxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33062", "l": "(R)-dihydrolipoamide + NAD(+) <=> (R)-lipoamide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434633", "l": "PIP2 binds inhibiting VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67712", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46247", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12263", "l": "ATP + NADH <=> ADP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19604", "l": "H(+) + NADH + O2 + orcinol <=> 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981443", "l": "CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76408", "l": "H2O + Xaa-L-Pro dipeptide => an L-alpha-amino acid + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299318", "l": "Activation of TASK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49300", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.208", "l": "\"protein-N(pi)-phosphohistidine--maltose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55027", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21382", "l": "AMP + diphosphate + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32480", "l": "2 iodide + L-tyrosine + 2 NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18174", "l": "(R)-octopamine => (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936380", "l": "Interaction of PIN1 with p-IRF3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322427", "l": "Beta-catenin recruits CBP/p300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781899", "l": "USP13 binds SIAH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23264", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211948", "l": "CYP3A4 can N-demethylate loperamide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110319", "l": "Elongation by POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804425", "l": "TP53 binds POU4F2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14272", "l": "2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18673", "l": "ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004331", "l": "fructose-2,6-bisphosphate 2-phosphatase activity", "d": ["Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787737", "l": "CSF3R binds CSF3 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416929", "l": "PTGFR binds PGF2a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19439", "l": "N-(beta-D-glucosyl)nicotinate + UDP => nicotinate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004733", "l": "pyridoxamine phosphate oxidase activity", "d": ["Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74885", "l": "GUCYs converts GTP to cGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44327", "l": "1-butyrylglycerol + H2O <=> butanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45236", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67337", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68005", "l": "AH2 + chloroethene => A + chloride + ethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43793", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41079", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60145", "l": "ATP + L-glutamate + L-glutamyl-[protein] => ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71910", "l": "GDP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.35", "l": "\"barrierpepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015537", "l": "xanthosine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69434", "l": "3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine => 3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647994", "l": "RAS proteins are depalmitoylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17875", "l": "ADP + an R-cob(III)alamin(in) + H(+) + phosphate => an R-cob(III)alamin(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098626", "l": "methylseleninic acid reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O."], "t": []}, {"i": "REACT:R-HSA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69859", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine = a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.156", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14474", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) => a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010355", "l": "homogentisate farnesyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38713", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65122", "l": "L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine => H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37085", "l": "[sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168894", "l": "Accumulation of M1 at the inner leaflet of the lipid bilayer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37616", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77439", "l": "a ganglioside GQ1c + H2O = a ganglioside GT1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59868", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine = 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30019", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + lipid A-core", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994020", "l": "IRF1 binds the promoters of Interferon alpha and beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18483", "l": "cyclohexylamine + sulfate => cyclohexylsulfamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030975", "l": "thiamine binding", "d": ["Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662620", "l": "MT3 binds cadmium (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57261", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939201", "l": "ESR dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607747", "l": "TRAF6 binds MALT1 oligomers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35903", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35444", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose => an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49344", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380780", "l": "Activation of Src (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607722", "l": "Active NIK phosphorylates IKKA dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65714", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-beta-L-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202489", "l": "Oligomerization of Bcl10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050278", "l": "sedoheptulose-bisphosphatase activity", "d": ["Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31978", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin <=> 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043682", "l": "P-type divalent copper transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72661", "l": "8-hydroxyquinoline N-oxide + H2O + NADP(+) => NADPH + O2 + quinolin-8-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14810", "l": "phenol + S-adenosyl-L-methionine => anisole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12365", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) => a quinol + beta-nicotinamide D-riboside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61319", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004471", "l": "malate dehydrogenase (decarboxylating) (NAD+) activity", "d": ["Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33433", "l": "(3E)-2-oxohex-3-enedioate => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43845", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 => (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41826", "l": "(3R)-hydroxyhexanoyl-[ACP] + NADP(+) => 3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378952", "l": "Thyrotropin is a heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58924", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol = (-)-maackiain + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41846", "l": "(2E)-octenoyl-[ACP] + H2O => (3R)-hydroxyoctanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782388", "l": "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810376", "l": "ING2 binds PI5P (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13193", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": [], "t": []}, {"i": "EC:5.4.99.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide mutase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64450", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874192", "l": "MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55293", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47821", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52607", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49888", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629237", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4167511", "l": "HLCS biotinylates ACACB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40455", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.130", "l": "\"tetraacyldisaccharide 4'-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14105", "l": "L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158357", "l": "factor XIIa binds SERPING1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102612", "l": "syn-pimaradiene 6beta-hydroxylase activity", "d": ["Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ = 6beta-hydroxy-syn-pimaradiene + NADP + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52833", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42140", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60820", "l": "H2O + NADPH = adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72604", "l": "(E)-sinapate + ATP + H(+) => (E)-sinapoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380311", "l": "Recruitment of Plk1 to centrosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814153", "l": "ADO oxidises 2AET to HTAU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25642", "l": "(1R,4S)-menthone + NADP(+) => (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31736", "l": "3-oxocholan-24-oyl-CoA + NAD(+) => 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404144", "l": "Parenchymal atROL translocates to HSCs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202443", "l": "Oligomerization of CARMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507875", "l": "Aquaporins passively transport urea into cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63629", "l": "ATP + hexadecanoate + holo-[ACP] => AMP + diphosphate + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24243", "l": "A + AMP + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77086", "l": "O2 + pre-flavunoidine + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-pre-flavunoidine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689544", "l": "UCHL5 binds INO80 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44554", "l": "H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71887", "l": "GTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65546", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc => a ganglioside GM1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64954", "l": "dCMP + H(+) + phosphate => dCDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28775", "l": "dinoflagellate luciferin + O2 = H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": [], "t": []}, {"i": "EC:1.13.12.18", "l": "\"dinoflagellate luciferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33079", "l": "6-amino-6-deoxyfutalosine + H2O = adenine + dehypoxanthine futalosine", "d": [], "t": []}, {"i": "EC:3.2.2.30", "l": "\"aminodeoxyfutalosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350901", "l": "Iodide is organified (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18652", "l": "D-galactonate <=> 2-dehydro-3-deoxy-D-galactonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73757", "l": "Binding of RRN3 to RNA Polymerase I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612501", "l": "SGK phosphorylates CREB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018715", "l": "9-phenanthrol UDP-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39641", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53028", "l": "lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59406", "l": "D-homoserine => L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.85", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785684", "l": "Fibronectin degradation by CTSG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862184", "l": "USP48 cleaves polyubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31180", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) => 3-oxododecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033791", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity", "d": ["Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24379", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983156", "l": "Polyubiquitination of substrate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56674", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => dihydro-4-coumaroyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64541", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390425", "l": "FAR1 reduces PalmCoA to HXOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47435", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58158", "l": "ADP + H(+) + 4 Na(+)(out) + phosphate => ATP + H2O + 4 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222376", "l": "NOX2 generates superoxide from oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31280", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15304", "l": "D-apiitol + NAD(+) <=> aldehydo-D-apiose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045030", "l": "G protein-coupled UTP receptor activity", "d": ["Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49385", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043743", "l": "LPPG:FO 2-phospho-L-lactate transferase activity", "d": ["Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13320", "l": "(2R,3R)-tartrate + H(+) <=> (R)-glycerate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756574", "l": "SARS-CoV-2 S binds SFTPD 12mer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56614", "l": "H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52156", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.44", "l": "\"phenylacetaldehyde oxime monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64308", "l": "3-aminobutanoate + pyruvate = acetoacetate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611852", "l": "ADRB3 bind ADR,NAd (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944223", "l": "Association of procollagen type V (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53765", "l": "allocholate + lithocholoyl-CoA => allocholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28299", "l": "(2E,6E)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034885", "l": "gamma-N-formylaminovinylacetate hydrolase activity", "d": ["Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37772", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51040", "l": "indole-3-pyruvate imine dimer = chromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43803", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11563", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> catechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48659", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420883", "l": "Opsins act as GEFs for G alpha-t (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14118", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58420", "l": "NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57537", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate => a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51675", "l": "glyoxal + H2O <=> glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797803", "l": "PTPRD binds SLITRK1-6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047307", "l": "diaminobutyrate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19686", "l": "(E)-feruloyl-CoA + tyramine => CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110219", "l": "Cleavage of thymine by TDG glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033745", "l": "L-methionine-(R)-S-oxide reductase activity", "d": ["Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59574", "l": "4-aminobutanoate + L-histidine => H2O + L-homocarnosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29515", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.132", "l": "\"GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018756", "l": "RHOH binds GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22783", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943279", "l": "GGT dimers hydrolyse GSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0016695", "l": "oxidoreductase activity, acting on hydrogen as donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor."], "t": []}, {"i": "EC:1.12.-.-", "l": "\"Acting on hydrogen as donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0019707", "l": "protein-cysteine S-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule."], "t": []}, {"i": "RHEA:63372", "l": "an acyl-CoA + L-cysteinyl-[protein] = an S-acyl-L-cysteinyl-[protein] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990606", "l": "membrane scission GTPase motor activity", "d": ["Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74136", "l": "petunidin + UDP-alpha-D-galactose => petunidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983259", "l": "Kinesins move along microtubules consuming ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031830", "l": "type 5A serotonin receptor binding", "d": ["Binding to a type 5A serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14928", "l": "D-mannitol 1-phosphate + NADP(+) <=> D-mannose 6-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63209", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal => 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097099", "l": "structural constituent of albumen", "d": ["The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450031", "l": "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45827", "l": "H(+) + L-serine <=> CO2 + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76057", "l": "H(+) + reticuline + S-adenosyl-L-homocysteine => norreticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18277", "l": "a thiol + S-adenosyl-L-methionine = a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.9", "l": "\"thiol S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800298", "l": "HGF dimer binds MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68444", "l": "5-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34813", "l": "dihydrocurcumin + H(+) + NADPH => NADP(+) + tetrahydrocurcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005330", "l": "dopamine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034918", "l": "3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52316", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63995", "l": "5-fluorocytidine + ATP <=> 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10089", "l": "sucrose + UDP-alpha-D-galactose => 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41921", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0030249", "l": "guanylate cyclase regulator activity", "d": ["Modulates the activity of guanylate cyclase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034896", "l": "3-formiminopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57848", "l": "2-oxoglutarate + O2 + scopoletin = CO2 + fraxetin + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.60", "l": "\"scopoletin 8-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156678", "l": "Activation of Cdc25C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41964", "l": "butanoyl-CoA + O2 = (2E)-butenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013004", "l": "RHOA binds effectors at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73273", "l": "H(+) + rhamnacene + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36238", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3318415", "l": "ATF2 acetylates histone H2B, H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45488", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46644", "l": "cortisol + H(+) + NADPH = 5beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149519", "l": "MMACHC decyanates CNCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388503", "l": "Oxytocin receptor bind oxytocin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35249", "l": "ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168947", "l": "Ligand binds to TLR10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36773", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21578", "l": "2-methylcholine + CO2 => carnitine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9658253", "l": "RAS:GTP binds PI3K (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31352", "l": "lupan-3beta,20-diol => (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134946", "l": "DDX41 ubiquitination by TRIM21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627072", "l": "RHOQ binds GOPC:CFTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52963", "l": "hyocholate + UDP-alpha-D-glucuronate <=> hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9681375", "l": "KIT binds ripretinib (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935785", "l": "RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13966", "l": "H2O + L,L-cystathionine => L-homocysteine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050574", "l": "2-(R)-hydroxypropyl-CoM dehydrogenase activity", "d": ["Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49379", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110498", "l": "DTOR is positively regulated by DRheb-GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466367", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0017070", "l": "U6 snRNA binding", "d": ["Binding to a U6 small nuclear RNA (U6 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10430", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.933232272557746", "identifiers": [{"i": "GO:0140098", "l": "catalytic activity, acting on RNA", "d": ["Catalytic activity that acts to modify RNA, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43192", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47610", "l": "3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA => 3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34578", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352059", "l": "SLC6A15-mediated amino acid uptake (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74723", "l": "Endosome acidification (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033934", "l": "glucan 1,4-alpha-maltotriohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796368", "l": "RIPK1 binds STUB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23010", "l": "D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62151", "l": "dGTP + dTMP <=> dGDP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66384", "l": "(2E,6E,10E,14E)-geranylfarnesol = scalar-17(25)-en-19-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674018", "l": "BRAP binds RAS:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19922", "l": "D-ribitol 5-phosphate + NADP(+) => D-ribulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53421", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine => H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864690", "l": "TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50234", "l": "biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851104", "l": "NPM1-ALK- and STAT3-dependent ICOS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71238", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] <=> [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27823", "l": "hydrogen sulfide + O-acetyl-L-homoserine => acetate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76758", "l": "decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,3-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0141003", "l": "histone H2AX kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone variant H2AX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11109", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46781", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102333", "l": "stearoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636461", "l": "PtpA binds Ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868666", "l": "CDK5:p25 phosphorylates JUN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-212642", "l": "L-Glutamine transport into neurons (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9833777", "l": "PKR binds activating host RNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38484", "l": "a 2,3-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189062", "l": "lactose + H2O => D-glucose + D-galactose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798372", "l": "ATM phosphorylates DYRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0071814", "l": "protein-lipid complex binding", "d": ["Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49685", "l": "H(+) + NADH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55502", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044022", "l": "histone H3S28 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68010", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856189", "l": "TNFSF8 binds TNFRSF8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213201", "l": "Formation of collagen fibres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0038199", "l": "ethylene receptor activity", "d": ["Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671737", "l": "p-T774-PKN1 binds CDC25C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69720", "l": "(indol-3-yl)acetate + ATP + H(+) => (indol-3-yl)acetyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23882", "l": "N(pros)-phospho-L-histidyl-[protein] + pyruvate => L-histidyl-[protein] + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12470", "l": "26-desgluco-avenacoside A + D-glucose => avenacoside A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59031", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249378", "l": "STING recruits TBK1 and STAT6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54030", "l": "a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102392", "l": "decanoate-[HmqF protein] ligase activity", "d": ["Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein = AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425861", "l": "Activation of Protein Kinase C novel isoforms (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29613", "l": "H(+) + NADPH + 2 nitric oxide => H2O + NADP(+) + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75671", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate = 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0097642", "l": "calcitonin family receptor activity", "d": ["Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61278", "l": "5-amino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-ornithine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46078", "l": "eicosanoyl-CoA + NAD(+) => (2E)-eicosenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41285", "l": "sphing-4-enine + tetracosanoate => H2O + N-tetracosanoyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700171", "l": "Active ALK phosphorylates PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50205", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44120", "l": "hexadecanoyl-CoA + octadecan-1-ol = CoA + octadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13035", "l": "keto-D-tagatose 6-phosphate => aldehydo-D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13950", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] => NADPH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156930", "l": "GTP-binding activates eEF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050537", "l": "mandelamide amidase activity", "d": ["Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58835", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14885", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63090", "l": "a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17147", "l": "2'-hydroxydaidzein + 2 H(+) + NADPH => 2'-hydroxy-2,3-dihydrodaidzein + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40818", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20979", "l": "a primary nitroalkane + H2O + O2 <=> an aldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694583", "l": "ABHD4 hydrolyses NAPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004957", "l": "prostaglandin E receptor activity", "d": ["Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49468", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose = a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76435", "l": "(2S,9S)-annullatin H + 2 A = (2S,9S)-annullatin D + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17197", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2", "d": [], "t": []}, {"i": "EC:1.2.3.13", "l": "\"4-hydroxyphenylpyruvate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950718", "l": "Expression of TCP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047069", "l": "7,8-dihydroxykynurenate 8,8a-dioxygenase activity", "d": ["Catalysis of the reaction: 7,8-dihydroxykynurenate + O2 = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183122", "l": "Factor D cleaves C3b-bound Factor B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20719", "l": "H(+) + H2O + S-adenosyl-L-homocysteine <=> NH4(+) + S-inosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21808", "l": "2,5-dioxopiperazine + H2O = glycylglycine", "d": [], "t": []}, {"i": "EC:3.5.2.13", "l": "\"2,5-dioxopiperazine hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390673", "l": "CHRM2,4 bind acetylcholine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.265", "l": "\"phosphatidylinositol dimannoside acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75291", "l": "glyoxylate(in) + oxalate(out) = glyoxylate(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29065", "l": "a menaquinol + CO2 => a menaquinone + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42389", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68074", "l": "L-thiazolidine-2-carboxylate + NADP(+) => Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73306", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) <=> H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660665", "l": "Caspase-8 binds MALT (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23545", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614778", "l": "MAG gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58205", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162657", "l": "Inactivation of Myt1 kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73057", "l": "estrone 3-sulfate(in) + hydrogencarbonate(out) => estrone 3-sulfate(out) + hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760402", "l": "ILF3 binds HOXC8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694677", "l": "ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56623", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O <=> 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77556", "l": "a 3-acyl-sn-glycerol + an acyl-CoA => a 1,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028583", "l": "Phosphorylation of YAP by LATS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75529", "l": "benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine => (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381608", "l": "cAMP activates EPAC2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021068", "l": "PalmS-ESRs bind CAVs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51973", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690023", "l": "NUBPL binds 4Fe-4S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69843", "l": "a 5,6-dihydrouridine in RNA + NAD(+) = a uridine in RNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.10", "l": "\"bacterial leucyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050140", "l": "nitrate reductase (cytochrome) activity", "d": ["Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48787", "l": "D-erythrulose 4-phosphate <=> D-erythrose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12553", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA => (E)-pinosylvin + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32492", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23120", "l": "a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.9", "l": "\"ABC-type dipeptide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445084", "l": "Phosphorylation of L1 by SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30859", "l": "dITP + H2O = dIDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200858", "l": "Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74425", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798374", "l": "DYRK2 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57845", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358789", "l": "Self-ubiquitination of RNF41 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77490", "l": "4-methylpentan-2-one + hydrogen cyanide <=> (2S)-2-hydroxy-2,4-dimethylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.28", "l": "\"alpha-L-rhamnosyl-(1->4)-beta-D-glucuronate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59610", "l": "beta-alanine + L-lysine => beta-alanyl-L-lysine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44856", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052819", "l": "heteroglycan 2-alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0046624", "l": "sphingolipid transporter activity", "d": ["Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)."], "t": []}, {"i": "REACT:R-HSA-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013069", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53661", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.141", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46736", "l": "H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10368", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.59", "l": "\"dTDP-4-amino-4,6-dideoxygalactose transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37387", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016596", "l": "thienylcyclohexylpiperidine binding", "d": ["Binding to thienylcyclohexylpiperidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64313", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin => dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49506", "l": "phosphinomethylisomalate => phosphinomethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.90", "l": "\"isoflavone 2'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43713", "l": "ATP + dodecanoate + H(+) => diphosphate + dodecanoyl-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15538", "l": "(2R)-3-sulfolactate + NADP(+) => 3-sulfopyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73054", "l": "hydrogencarbonate(in) + taurocholate(out) <=> hydrogencarbonate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754964", "l": "ADA deamidates RBV (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47012", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide = [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26389", "l": "all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}, {"i": "EC:1.13.11.71", "l": "\"carotenoid-9',10'-cleaving dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.188", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21989", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside => 4'''-demalonylsalvianin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17869", "l": "5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863471", "l": "LDLR is bound by DAB2 and ARH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15360", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0055102", "l": "lipase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54632", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA = 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227893", "l": "TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.117", "l": "\"D-arabinose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388605", "l": "POMC(138-176) binds MC2R (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691174", "l": "RAC1 binds effectors at the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1972385", "l": "ADP-Ribosylation of HNP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11033", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate => 3-chloro-cis,cis-muconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726949", "l": "PTGIR binds PTGIR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31668", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606624", "l": "Active FLT3:GRB2 binds GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688786", "l": "ATXN3 binds RAD23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49554", "l": "H(+) + L-lysyl-[protein] + lactate => H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016150", "l": "translation release factor activity, codon nonspecific", "d": ["A translation release factor that is not specific to particular codons; binds to guanine nucleotides."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654515", "l": "KAL1 binds HS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17067", "l": "(R)-5-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674019", "l": "BRAP binds KSR1:MARK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74435", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16688", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA <=> a dolichyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140762", "l": "glucose dehydrogenase (FAD, quinone) activity", "d": ["Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11530", "l": "2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52411", "l": "4-phospho-D-erythronate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76316", "l": "L-aspartate(in) + L-methionine(out) => L-aspartate(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34206", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> aureusidin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12647", "l": "(indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58540", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22284", "l": "2 H(+) + H2O + N-carbamoylputrescine = CO2 + NH4(+) + putrescine", "d": [], "t": []}, {"i": "EC:3.5.1.53", "l": "\"N-carbamoylputrescine amidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37311", "l": "ATP + glycyl-L-glutamine(out) + H2O = ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341669", "l": "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31359", "l": "FMNH2 + nitrilotriacetate + O2 = aminodiacetate + FMN + glyoxylate + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.10", "l": "\"nitrilotriacetate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43018", "l": "2-aminoprop-2-enoate + an alkyl thiol => an S-alkyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57709", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0005337", "l": "nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473584", "l": "Collagen type III degradation by MMP15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30501", "l": "(E)-2-methylpropanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015284", "l": "fructose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16143", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADH => 2'-deoxymugineate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033938", "l": "1,6-alpha-L-fucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26390", "l": "all-trans-beta-carotene + O2 => all-trans-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38127", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27324", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65436", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.88", "l": "\"GDP polyribonucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63858", "l": "(2R)-2-hydroperoxytetradecanoate => O2 + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251942", "l": "Hikeshi binds HSP70s:ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75219", "l": "H2O + L-fucono-1,5-lactone = H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63105", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 => 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944257", "l": "Association of procollagen type XXIV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73742", "l": "dopamine(in) + 2 H(+)(out) <=> dopamine(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195304", "l": "Association of beta-catenin with the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33404", "l": "ATP + L-threonine => diphosphate + L-threonyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14144", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36546", "l": "H2O + mycothiol S-conjugate <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24846", "l": "2 isomaltose => cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67447", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA <=> a long-chain fatty aldehyde + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627072", "l": "RHOQ binds GOPC:CFTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62335", "l": "ADP + ATP <=> adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32040", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => AMP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73784", "l": "dimethylallyl diphosphate + tardioxopiperazine A => diphosphate + echinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55333", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine => a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33324", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483229", "l": "HHAT G287V doesn't palmitoylate Hh-Np (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617927", "l": "FOXO4 binds ATXN3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64919", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670436", "l": "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694333", "l": "3CLp forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950456", "l": "IL12B dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69527", "l": "D-sorbitol + O2 <=> D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52472", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53220", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698988", "l": "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75891", "l": "Abortive Initiation After Second Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696271", "l": "RND1 binds effectors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75050", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) <=> N(omega),N(omega)-dimethyl-L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014449", "l": "RHOG binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44018", "l": "2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH => 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56856", "l": "A + an aldehyde + H2O = a carboxylate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247836", "l": "Retromer recycles WLS to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102774", "l": "p-coumaroyltriacetic acid lactone synthase activity", "d": ["Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( = p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69490", "l": "H2O2 + tetradecanal => O2 + tetradecan-1-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59955", "l": "2,6-dimethylheptanoyl-CoA + H2O <=> 2,6-dimethylheptanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59564", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone = H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71992", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => (-)-astellatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27731", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) => beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75709", "l": "10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610726", "l": "The IFT-A complex recruits TULP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26122", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18357", "l": "NADP(+) + tropine = H(+) + NADPH + tropinone", "d": [], "t": []}, {"i": "EC:1.1.1.206", "l": "\"tropinone reductase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794347", "l": "Homer1,2,3 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36771", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.308", "l": "\"GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793382", "l": "TBX6 and LEF1:CTNNB1 bind the MSGN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050571", "l": "1,5-anhydro-D-fructose reductase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15264", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32332", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) => (1S,4R)-fenchone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58796", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA = a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75822", "l": "(5Z,8Z)-octadecadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430183", "l": "NCK binds PAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50947", "l": "3-phenylpropanoate + NAD(+) <=> (E)-cinnamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51989", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => 18S-resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54347", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29092", "l": "a ubiquinone + 5 H(+)(in) + NADH => a ubiquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17939", "l": "methylglyoxal + phosphate => dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34308", "l": "4-nitrocatechol + NADPH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350578", "l": "NQO1 interaction with ODC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665700", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381727", "l": "RAP1A exchanges GDP for GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58125", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52682", "l": "CoA + H(+) + N-acetyl-L-alpha-phenylglycine => acetyl-CoA + L-alpha-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31364", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) => 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62437", "l": "L-lyxonate => 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73756", "l": "2 H(+)(out) + histamine(in) => 2 H(+)(in) + histamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40172", "l": "dodecanoyl-CoA + O2 => (2E)-dodecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047402", "l": "protein-glucosylgalactosylhydroxylysine glucosidase activity", "d": ["Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662706", "l": "Dopachrome transforms to DHI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11674", "l": "4-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987039", "l": "JAK1 binds IL20RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10391", "l": "GTP + oxaloacetate <=> CO2 + GDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68300", "l": "L-seryl-[protein] + tetradecanoyl-CoA = CoA + O-tetradecanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30996", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74723", "l": "Endosome acidification (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55276", "l": "9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848939", "l": "PTK6 binds KHDRBS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56121", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448948", "l": "Phosphorylation of E proteins by p38 MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54386", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5alpha-steroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668545", "l": "NIK autophosphorylates on T559 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.202", "l": "\"endo-chitodextinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718020", "l": "PTGFR binds PTGFR agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46085", "l": "H2O + sn-glycerol 1-phosphate => glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37466", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013108", "l": "GDIs block activation of RHOC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.11", "l": "\"ribonuclease Z\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19884", "l": "GTP + L-lysyl-[protein] <=> diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9833973", "l": "ISGylation of PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029454", "l": "Autophosphorylation of PAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.1", "l": "\"short-chain acyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54900", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH = hexadecanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43453", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42428", "l": "clavaminate = (3R,5R)-clavulanate-9-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878117", "l": "RUNX3 binds ZFHX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67257", "l": "H2O + NAD(+) + propanal => 2 H(+) + NADH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047597", "l": "6-oxocineole dehydrogenase activity", "d": ["Catalysis of the reaction: 6-oxocineole + H+ + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051268", "l": "alpha-keto amide reductase activity", "d": ["Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218805", "l": "PKC autophosphorylates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22788", "l": "dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:2.1.1.3", "l": "\"thetin--homocysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813749", "l": "ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60784", "l": "2-oxoglutarate + gibberellin A24 + O2 = CO2 + gibberellin A25 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004978", "l": "corticotropin receptor activity", "d": ["Combining with corticotropin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022877", "l": "protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76009", "l": "(3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate pentamer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44950", "l": "1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416358", "l": "G alpha (q) inhibits PI3K alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034319", "l": "alcohol O-butanoyltransferase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807106", "l": "PTEN undergoes monoubiquitination (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033560", "l": "folate reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74228", "l": "H2O + L-threonyl-tRNA(Ile) => L-threonine + tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052619", "l": "coenzyme F420-1:gamma-L-glutamate ligase activity", "d": ["Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437192", "l": "PDPK1 binds PRKCZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56579", "l": "a globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373716", "l": "DCC interacting NCK-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112037", "l": "Inactivation of PLC beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51371", "l": "glycine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696564", "l": "USP25 deubiquitinates DDX58 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12581", "l": "H2O + NAD(+) + tauropine => H(+) + NADH + pyruvate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661425", "l": "BIL:ALB dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28639", "l": "(2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.62", "l": "\"(-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69402", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35255", "l": "ATP + H2O + lipid A-core(in) = ADP + H(+) + lipid A-core(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696958", "l": "USP44 deubiquitinates CDC20 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47661", "l": "acetyl-CoA + L-methionine sulfoximine => CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004598", "l": "peptidylamidoglycolate lyase activity", "d": ["Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69992", "l": "3-dehydro-6-deoxoteasterone + NADP(+) => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29207", "l": "a menaquinol(in) + dimethyl sulfoxide(out) = a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106301", "l": "arachidonic acid 5,6-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid."], "t": []}, {"i": "RHEA:49936", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733292", "l": "AMY1-3 bind pramlintide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22560", "l": "(3R)-vestitone + NADP(+) = 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.45", "l": "\"2'-hydroxyisoflavone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0047267", "l": "undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol."], "t": []}, {"i": "EC:2.4.1.54", "l": "\"undecaprenyl-phosphate mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35715", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O = (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37234", "l": "H2O + L-alaninamide <=> L-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948621", "l": "miR-20 microRNAs bind VAPA mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30864", "l": "4-O-phospho-L-tyrosine + H2O => L-tyrosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11425", "l": "ATP + L-threonyl-[myosin heavy-chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65789", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114284", "l": "Release of Cytochrome c from mitochondria (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9710959", "l": "p-STAT1 dimer binds KPNA1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0004843", "l": "cysteine-type deubiquitinase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016692", "l": "NADH peroxidase activity", "d": ["Catalysis of the reaction: H2O2 + NADH + H+ = 2 H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64194", "l": "(9Z)-octadecenoate + L-lysine => H2O + N-(9Z-octadecenoyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029158", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57329", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76177", "l": "glycyl-L-glutamate(in) + 3 H(+)(in) => glycyl-L-glutamate(out) + 3 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11456", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.101", "l": "\"alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73644", "l": "CTP(out) + IDP(in) => CTP(in) + IDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45264", "l": "(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44973", "l": "(R)-carnitine + hexanoyl-CoA => CoA + O-hexanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428625", "l": "Vesicular inhibitory amino acid transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10389", "l": "GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54337", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75966", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione <=> 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760641", "l": "HOXC8 binds CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974737", "l": "NOTCH2 binds MDK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450088", "l": "GLUT1 tetramer binds 4xATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1980125", "l": "ITCH binds DTX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759325", "l": "NFE2L2 binds the GSTA3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672163", "l": "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56607", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37025", "l": "(6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32780", "l": "ATP + Co(2+)(out) + H2O => ADP + Co(2+)(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051744", "l": "3,8-divinyl protochlorophyllide a 8-vinyl reductase activity", "d": ["Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0043325", "l": "phosphatidylinositol-3,4-bisphosphate binding", "d": ["Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684218", "l": "M protein oligomerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694409", "l": "Nucleotide exchange on RAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009702", "l": "L-arabinokinase activity", "d": ["Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20196", "l": "(R)-mevalonate + NADP(+) <=> (R)-mevaldate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202164", "l": "Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73388", "l": "H(+)(in) + malonate(out) + phosphate(in) => H(+)(out) + malonate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27315", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 => 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32753", "l": "choline(in) => choline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13239", "l": "D-glucosamine 6-phosphate + L-glutamate => D-fructose 6-phosphate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19957", "l": "2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47000", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.6.1.4", "l": "\"NAD(P)(+) transhydrogenase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032770", "l": "Translocation of YAP1 to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012835", "l": "GDIs block activation of RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388833", "l": "Phosphorylation of CTLA-4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51515", "l": "H2O + oxamate <=> NH4(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34394", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose <=> [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37187", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0045543", "l": "gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66236", "l": "IC-asc-C9-CoA + O2 = H2O2 + IC-asc-DeltaC9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983144", "l": "Transport of Antigen peptide in to ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44932", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29550", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16351", "l": "A + chlorite + H2O => AH2 + chlorate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47478", "l": "(2E)-tetradecenoyl-CoA => (3E)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034875", "l": "NTRK3 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811479", "l": "ING2 recruits EP300 to TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44563", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate <=> 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874078", "l": "PTK2 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008441", "l": "3'(2'),5'-bisphosphate nucleotidase activity", "d": ["Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72718", "l": "(R)-dihydrolipoate + ATP + H(+) <=> diphosphate + N(6)-[(R)-dihydrolipoyl]-5'-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18628", "l": "D-galactose + NADP(+) <=> D-galactono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102467", "l": "scutellarein 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein = UDP( + scutellarin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30968", "l": "9,9',15-tri-cis-zeta-carotene => 9,9'-di-cis-zeta-carotene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73003", "l": "anthranilate + 2 ATP + L-tryptophan = (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042657", "l": "MHC class II protein binding, via lateral surface", "d": ["Binding to the lateral surface of major histocompatibility complex class II molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34292", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44524", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23874", "l": "(R)-lactaldehyde + H(+) + NADH => (R)-propane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20978", "l": "an aldehyde + H(+) + H2O2 + nitrite => a primary nitroalkane + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75917", "l": "dihydroxyacetone + H(+) + NADH + NH4(+) => H2O + NAD(+) + serinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848596", "l": "PTK6 binds PXN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254291", "l": "ERBB4s80 binds STAT5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004061", "l": "arylformamidase activity", "d": ["Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.89", "l": "\"Pro-Pro endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66683", "l": "ATP + coproporphyrinogen III(in) + H2O <=> ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76897", "l": "2-hexyl-5-(5-hydroxypentyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hexyl-5-pentylresorcinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0106254", "l": "lipid sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0140333", "l": "glycerophospholipid flippase activity", "d": ["Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19857", "l": "a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21577", "l": "carnitine + H(+) => 2-methylcholine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48583", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate <=> [pyruvate, water dikinase] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49102", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester => H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32641", "l": "(6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71036", "l": "L-phenylalanine(out) + L-serine(in) => L-phenylalanine(in) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46503", "l": "2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52718", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008110", "l": "Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51905", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37242", "l": "2',3'-cyclophospho-UMP + H2O <=> H(+) + uridine 2'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162657", "l": "Inactivation of Myt1 kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24227", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) <=> 4-methylcatechol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010859", "l": "calcium-dependent cysteine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49991", "l": "acetone + H(+) + NADPH + O2 <=> H2O + methyl acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418172", "l": "F2R binds ARRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53259", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61351", "l": "ATP + estrone 3-sulfate(in) + H2O <=> ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44569", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) => 2-all-trans-hexaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0016890", "l": "site-specific endodeoxyribonuclease activity, specific for altered base", "d": ["Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks."], "t": []}, {"i": "EC:3.1.25.-", "l": "\"Site-specific endodeoxyribonucleases specific for altered bases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66509", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975040", "l": "KRAB-ZNF / KAP Interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50775", "l": "H2O + nitroethane + O2 <=> acetaldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70263", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34729", "l": "15-methylhexadecasphinganine + a carboxylate => H2O + N-acyl-15-methylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26385", "l": "all-trans-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": [], "t": []}, {"i": "EC:1.13.11.75", "l": "\"all-trans-8'-apo-beta-carotenal 15,15'-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158860", "l": "SULT1A1 dimer sulfonates NHABP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672083", "l": "KTN1 binds Kinesin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372903", "l": "lactate + NAD+ <=> pyruvate + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042926", "l": "3-hydroxyphenylpropionic acid transmembrane transporter activity", "d": ["Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028598", "l": "Phosphorylation of YAP by LATS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28859", "l": "Ag(+)(in) + H(+)(in) = Ag(+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44275", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32748", "l": "ethanolamine(in) => ethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388830", "l": "PI3K binds ICOS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879562", "l": "SLCO2B1 has a narrow substrate specificity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56722", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67513", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653745", "l": "Translation of ATF5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130349", "l": "Generation of CLIP from lip10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002466", "l": "Formation of allysine by LOX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25703", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102912", "l": "(-)-lactol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-lactol + NAD = H+ + (-)-matairesinol + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48347", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose <=> a D-galactosylceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202713", "l": "CD84 homodimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216222", "l": "COS binds to SMO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71611", "l": "(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019894", "l": "kinesin binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190682", "l": "Connexin synthesis (generic) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102293", "l": "pheophytinase b activity", "d": ["Catalysis of the reaction: pheophytin b + H2O = H+ + pheophorbide b + phytol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39718", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564143", "l": "Collagen type X degradation by MMP1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20300", "l": "an anilide + H2O <=> a carboxylate + aniline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442749", "l": "CaMKK autophosphorylates in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77115", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35865", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22085", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48269", "l": "4',4'-dihydroxyechinenone => canthaxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16529", "l": "ADP + H(+) + sulfate = adenosine 5'-phosphosulfate + phosphate", "d": [], "t": []}, {"i": "EC:2.7.7.5", "l": "\"sulfate adenylyltransferase (ADP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004687", "l": "myosin light chain kinase activity", "d": ["Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54478", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+) => 1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38460", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA => 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421831", "l": "trans-Golgi Network Coat Assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48441", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76376", "l": "3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => 3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167133", "l": "Activation of GT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36173", "l": "1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) => a 1-acylglycerone 3-phosphate + a long chain fatty alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676257", "l": "Formation of the SET1A complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691004", "l": "XPC binds RAD23 and CETN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53159", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.5", "l": "\"renalase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "38.762277864758545", "identifiers": [{"i": "GO:0003824", "l": "catalytic activity", "d": ["Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250986", "l": "botG HC:LC binds SYT1 and GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29990", "l": "adenosine(in) + H(+)(in) <=> adenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780958", "l": "SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56393", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30779", "l": "D-gluconate + FAD + H(+) = 2-dehydro-D-gluconate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130731", "l": "Formation of COPII vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53488", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48776", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036068", "l": "Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21637", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35782", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> mutildienyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25301", "l": "acetaldehyde + H2O + NADP(+) <=> acetate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70834", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) <=> L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61454", "l": "11a-hydroxy-oxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + oxytetracycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26542", "l": "(R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452097", "l": "Recruited STAT5 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37827", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42365", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047685", "l": "amine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17396", "l": "3-maleylpyruvate <=> 3-fumarylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034826", "l": "1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797961", "l": "CHDH oxidises Cho to BETALD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30116", "l": "decanoyl-[ACP] + H2O => decanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202702", "l": "CD177 binds PECAM-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10442", "l": "D-gluconate + H(+) => D-glucono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799409", "l": "HIPK2 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008412", "l": "CDK4 phosphorylates RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56840", "l": "5-amino-2-hydroxybenzoate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.86", "l": "\"5-aminosalicylate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000309", "l": "nicotinamide-nucleotide adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950387", "l": "CANX binds EBI3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53804", "l": "allodeoxycholoyl-CoA + ursodeoxycholate = allodeoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11572", "l": "FAD + H(+) + H2O + lithocholate = chenodeoxycholate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73456", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin => 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21182", "l": "D-glucose + indole-3-acetyl-1D-myo-inositol => 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16985", "l": "3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197958", "l": "FPGS-2 transforms THF to THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23931", "l": "H2O + N(8)-acetylspermidine <=> acetate + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047435", "l": "5-guanidino-2-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034029", "l": "2-oxoglutarate carboxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H+ + oxalosuccinate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73511", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 = CO2 + formaldehyde + pilosin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50546", "l": "prostaglandin B2 => prostaglandin C2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008499", "l": "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732629", "l": "PPARG binds PPARG agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032775", "l": "YAP1 binds TEAD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10856", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481007", "l": "Exocytosis of platelet alpha granule contents (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16807", "l": "CO2 + deacetylcephalosporin C + succinate => 2-oxoglutarate + deacetoxycephalosporin C + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676133", "l": "CD74 binds MIF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198621", "l": "AKT phosphorylates caspase-9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42612", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17055", "l": "beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13066", "l": "ATP + H2O => ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0016888", "l": "endodeoxyribonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57521", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163310", "l": "TFAM binds to mitochondrial promoters (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603797", "l": "PEX19:PEX3 binds PEX16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11377", "l": "(19E)-geissoschizine + NADP(+) => 4,21-dehydrogeissoschizine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140988", "l": "ADP:inorganic phosphate antiporter activity", "d": ["Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + inorganic phosphate(in) = ADP(in) + inorganic phosphate(out)."], "t": []}, {"i": "RHEA:65844", "l": "ADP(out) + H(+)(out) + phosphate(in) = ADP(in) + H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043842", "l": "Kdo transferase activity", "d": ["Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050247", "l": "raucaffricine beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34878", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47296", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57392", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine = 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035716", "l": "chemokine (C-C motif) ligand 12 binding", "d": ["Binding to chemokine (C-C motif) ligand 12."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65662", "l": "AH2 + calcidiol => A + calciol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.078697315966167", "identifiers": [{"i": "GO:0008276", "l": "protein methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group (CH3-) to a protein."], "t": []}, {"i": "REACT:R-HSA-9632182", "l": "PRMT1 methylates ESRs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77089", "l": "N-pyruvoyl-L-glutamate + salicylate => isochorismoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50200", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20818", "l": "3-oxoglycyrrhetinate + H(+) + NADPH => 3alpha-hydroxyglycyrrhetinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32242", "l": "gamma-carotene <=> all-trans-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44589", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21996", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.125", "l": "\"1-alkyl-2-acetylglycerol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2203480", "l": "COLEC11 binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157632", "l": "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686587", "l": "ABL1 phosphorylates RAD52 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788999", "l": "HV1-mediated H+ transfer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50805", "l": "glutathione + prostaglandin J2 => prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74806", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72075", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine = ADP + H(+) + ophthalmate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26416", "l": "a primary amine + an aldehyde + H2O2 => a secondary aliphatic amine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247840", "l": "WLS binds WNT ligands in the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446212", "l": "Flipping of the N-glycan precursor to inside the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507719", "l": "p62:MEKK3 binds to TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016401", "l": "palmitoyl-CoA oxidase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22801", "l": "cycloeucalenol => obtusifoliol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66680", "l": "ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45233", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445071", "l": "Reinsertion of L1 into the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15216", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA <=> CoA + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097726", "l": "LEM domain binding", "d": ["Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70308", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72663", "l": "De novo formation of eIF2:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179402", "l": "Active MMP3 can cleave pro-HBEGF to form active HBEGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60161", "l": "ATP + H2O + vincristine(in) => ADP + H(+) + phosphate + vincristine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29465", "l": "K(+)(out) => K(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190519", "l": "Internalization of gap junction plaques (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852337", "l": "GTSE1 binds TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964619", "l": "PAK1 binds ARHGEF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31384", "l": "(S)-2,3-epoxysqualene => lupeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48072", "l": "a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66892", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56149", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine => CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68582", "l": "ADP + H(+) + L-kynurenine(in) + phosphate => ATP + H2O + L-kynurenine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24755", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite <=> 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.10", "l": "\"crossover junction endodeoxyribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68325", "l": "1D-myo-inositol 2,5-bisphosphate + H2O => 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55211", "l": "(4R)-hydroxysphinganine 1-phosphate <=> (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10136", "l": "2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.47", "l": "\"tartronate-semialdehyde synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53460", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68112", "l": "H2O + propanamide = NH4(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18409", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.3", "l": "\"microbial collagenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851118", "l": "pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031737", "l": "CX3C chemokine receptor binding", "d": ["Binding to a CX3C chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204863", "l": "Interaction of Tie2 with Ang2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418904", "l": "A1 and A3 receptors bind adenosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18691", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034800", "l": "trinitrophenol dihydride denitratase activity", "d": ["Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322434", "l": "XIAP dissociates from ub-TLE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244500", "l": "botE:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58212", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012654", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13862", "l": "D-xylose + NAD(+) => D-xylono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10915", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33525", "l": "acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) => ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781953", "l": "YOD1 binds VCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18976", "l": "2-oxoglutarate + deacetoxyvindoline + O2 <=> 4-O-deacetylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40060", "l": "decanoyl-CoA + H2O => CoA + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003908", "l": "methylated-DNA-[protein]-cysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42704", "l": "hercynine + L-cysteine + O2 = H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}, {"i": "EC:1.21.3.10", "l": "\"hercynylcysteine S-oxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23899", "l": "5-dehydro-4-deoxy-D-glucuronate <=> 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417829", "l": "P2RY12 binds ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685319", "l": "CX3 complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19914", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) => a 3-oxoacyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22639", "l": "dCTP + H2O <=> dCMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013110", "l": "RHOC binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19569", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.61", "l": "\"tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45374", "l": "(9Z)-octadecenoate + sphinganine => H2O + N-(9Z-octadecenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42625", "l": "(Z)-3-ureidoacrylate + H(+) + H2O => (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17969", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": [], "t": []}, {"i": "EC:6.3.2.7", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005352", "l": "alpha-glucoside:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66247", "l": "ATP + H(+) + IC-asc-C9 <=> diphosphate + IC-asc-C9-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57534", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate => a 5'-end ribonucleotide-RNA + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67449", "l": "(2R)-2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41814", "l": "butanoyl-[ACP] + NADP(+) => (2E)-butenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035242", "l": "protein-arginine omega-N asymmetric methyltransferase activity", "d": ["Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56788", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin = cob(II)alamin-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018717", "l": "9-phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45912", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19369", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.85", "l": "\"protein-histidine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4837364", "l": "Secretion of SOD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632924", "l": "TP53 stimulates GLS2 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12453", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40202", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69833", "l": "6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0036455", "l": "iron-sulfur transferase activity", "d": ["Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)."], "t": []}, {"i": "REACT:R-HSA-2564828", "l": "CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36409", "l": "diphosphate + H2O + L-threonylcarbamoyladenylate => ATP + hydrogencarbonate + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912727", "l": "CBL binds VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72314", "l": "glutathione(in) + taurocholate(out) <=> glutathione(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28132", "l": "baicalein + D-glucuronate + H(+) => baicalin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9837337", "l": "DCAKD phosphorylates DP-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047522", "l": "15-oxoprostaglandin 13-oxidase activity", "d": ["Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850831", "l": "KLK5 cleaves and activates KLK8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390141", "l": "D inhibits WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38523", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32121", "l": "GDP + H(+) + validoxylamine A 7'-phosphate => GDP-valienol + validamine 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39408", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19447", "l": "anthranilate + CO2 + H(+) => 2,3-dihydroxyindole + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050057", "l": "linamarin synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873918", "l": "Transphosphorylation of JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56451", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64140", "l": "an N-(fatty acyl)-L-asparagine + H2O = a fatty acid + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66633", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682377", "l": "LC3 de-lipidation by ATG4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22178", "l": "20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983156", "l": "Polyubiquitination of substrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034857", "l": "2-(methylthio)benzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68610", "l": "Formation of ORC(2-5) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609921", "l": "SGTA binds Tail-anchored protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74970", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) <=> a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70568", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25521", "l": "an acyl-CoA + pseudotropine => CoA + H(+) + O-acylpseudotropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19873", "l": "dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.2", "l": "\"steryl-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61561", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48843", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74934", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 <=> a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006169", "l": "Factor H binds host cell surface markers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668545", "l": "NIK autophosphorylates on T559 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31045", "l": "2 H(+) + methylmalonate + NADH => (S)-2-methyl-3-oxopropanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73125", "l": "H(+) + rhamnacene + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69745", "l": "(S)-2-benzylsuccinyl-CoA + succinate => (S)-2-benzylsuccinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975879", "l": "Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950504", "l": "IL27 binds CRLF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814374", "l": "Kazrin binds periplakin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.9.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28094", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.27", "l": "\"undecaprenyl-diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41085", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60416", "l": "diglucosyl-enterobactin + H2O = H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62221", "l": "phyllostine => neopatulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102725", "l": "24-methyldesmosterol reductase activity", "d": ["Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57182", "l": "N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => L-lysyl-[protein] + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10129", "l": "all-trans-violaxanthin => all-trans-neoxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016715", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor."], "t": []}, {"i": "EC:1.14.17.-", "l": "\"With reduced ascorbate as one donor, and incorporation of one atom of oxygen\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13829", "l": "GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357828", "l": "RIPK1 is cleaved by CASP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371422", "l": "ATP hydrolysis by HSP70 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607736", "l": "MALT1 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35539", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29363", "l": "dCMP + H2O = 2'-deoxycytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785213", "l": "LIPC dimer binds heparin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10527", "l": "2-oxoglutarate + H(+) <=> CO2 + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64608", "l": "L-threonyl-[protein] + UTP = diphosphate + uridylyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51045", "l": "indole-3-pyruvate imine dimer => CO2 + NH4(+) + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25325", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67778", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38585", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74766", "l": "rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803104", "l": "DCD forms oligomeric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470073", "l": "Peroxynitrite enters the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52981", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77699", "l": "a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1balpha  (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75603", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71254", "l": "L-xylopyranose <=> L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706837", "l": "AR binds AR antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67009", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69848", "l": "a 5,6-dihydrouridine in RNA + NADP(+) => a uridine in RNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222353", "l": "Protonation of superoxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022175", "l": "MECP2:CREB1 complex binds SLC2A3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983307", "l": "IL15 binds IL15RA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77284", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.4", "l": "\"fatty-acid peroxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69636", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798139", "l": "TP53 stimulates CASP10 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449855", "l": "IL10 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66026", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782820", "l": "USP17 deubiquitinates SUDS3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60849", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37713", "l": "1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30306", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63574", "l": "L-arginine + neurotensin-(1-7) => H2O + neurotensin-(1-8)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0031806", "l": "G protein-coupled histamine receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) histamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28388", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76166", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42968", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.206", "l": "\"tRNA (cytidine(56)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59883", "l": "4-hydroxyphenylacetate + FMNH2 + O2 <=> 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191656", "l": "Closure of gap junction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450488", "l": "BRF1 Complex recruits RNA degradation activities (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16582", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 => 2 Fe(III)-[cytochrome c] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035851", "l": "Krueppel-associated box domain binding", "d": ["Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31789", "l": "(13R)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69114", "l": "2-oxoadipate + glycine => glyoxylate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984689", "l": "Kinesin-7 is a dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14346", "l": "H(+) + L-tyrosine => CO2 + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043786", "l": "cinnamate reductase activity", "d": ["Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985157", "l": "OAS3 binds viral dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796061", "l": "NFE2L2 dependent ATF4 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653936", "l": "Formation of Ragulator complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197963", "l": "DHFR2 reduces FOLA to DHF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043819", "l": "precorrin-6A synthase (deacetylating) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + H2O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H+ + precorrin-6X."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080089", "l": "sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159773", "l": "Furin cleaves pro-protein S to protein S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13963", "l": "ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate => ATP + H2O + Mg(2+) + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730841", "l": "Phosphorylation and activation of VAV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59634", "l": "D-xylobiono-1,5-lactone + H2O2 => D-xylobiose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936851", "l": "AHRR binds ARNT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357472", "l": "PAK1-3 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730872", "l": "Activation of Calcineurin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18329", "l": "(1S,3R,5S)-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.228", "l": "\"(+)-sabinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76330", "l": "L-aspartate(in) + L-phenylalanine(out) <=> L-aspartate(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757578", "l": "ALB binds PREDN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411383", "l": "NLK phosphorylates TCF/LEF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67695", "l": "ATP + H2O + hexadecanedioate(in) <=> ADP + H(+) + hexadecanedioate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033472", "l": "FGFR2c mutants bind an expanded range of ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26413", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34228", "l": "5-nitrosalicylate + O2 => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61806", "l": "diphosphate + L-alanyl-5'-AMP => ATP + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53327", "l": "2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20825", "l": "adenosine + ATP => ADP + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46534", "l": "a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36563", "l": "GDP-beta-L-colitose + NADP(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560498", "l": "Expression of Lipoprotein lipase (LPL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662710", "l": "IL6 gene produces IL6 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39427", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018774", "l": "RHOBTB1 binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047099", "l": "CDP-4-dehydro-6-deoxyglucose reductase activity", "d": ["Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985097", "l": "OAS2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442749", "l": "CaMKK autophosphorylates in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15249", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose = 1-O-galloyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12537", "l": "H(+) + L-arogenate => CO2 + H2O + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58333", "l": "(E)-non-2-en-1-ol + NADP(+) => (E)-non-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27954", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + presilphiperfolan-8beta-ol", "d": [], "t": []}, {"i": "EC:4.2.3.74", "l": "\"presilphiperfolanol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44988", "l": "(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.19", "l": "\"chondroitin B lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25599", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35800", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51534", "l": "5-hydroxyisourate + H2O + NADP(+) => H(+) + NADPH + O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42783", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201515", "l": "Active ALK recruits PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820895", "l": "DIS3L2 binds PABPN1 in PABPN1:uridylated mRNA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59843", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49623", "l": "D-erythritol 1-phosphate + NADP(+) <=> D-erythrulose 1-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102411", "l": "quercetin-3,4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) = quercetin 3,4'-O-diglucoside + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16668", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O <=> (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696271", "l": "RND1 binds effectors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66954", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31781", "l": "13-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990405", "l": "protein antigen binding", "d": ["Binding to a protein antigen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33733", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944247", "l": "Association of procollagen type VI (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25963", "l": "benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877902", "l": "Activated AR binds RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37745", "l": "phosphate + prenyl-FMNH2 => dimethylallyl phosphate + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10232", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}, {"i": "EC:2.4.2.20", "l": "\"dioxotetrahydropyrimidine phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76362", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23775", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) <=> 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21309", "l": "(S)-2,3-epoxysqualene => cycloartenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77437", "l": "a ganglioside GQ1c + CMP + H(+) => a ganglioside GT1c + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75428", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42229", "l": "17beta-estradiol + A => AH2 + estrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37400", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928624", "l": "EPHBs bind EFNBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.237", "l": "\"hydroxyphenylpyruvate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45395", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56362", "l": "13-dihydrocarminomycin + H2O + NADP(+) => 13-deoxycarminomycin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29320", "l": "H2O + sn-glycero-3-phosphoethanolamine => ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940134", "l": "FOLR2 binds FOLA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59151", "l": "ATP + CoA + marinolate C <=> AMP + diphosphate + marinoloyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36304", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17615", "l": "H(+) + NADH + scyllo-inosose => NAD(+) + scyllo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102478", "l": "beta-L-arabinofuranosidase activity", "d": ["Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18242", "l": "D-lysine => (2R,5S)-2,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417843", "l": "P2Y13 binds ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31749", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39661", "l": "a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35579", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 = anthocyanin A11 + D-glucose", "d": [], "t": []}, {"i": "EC:2.3.1.n12", "l": "\"sinapoyl-beta-D-glucose:anthocyanin sinapoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58872", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "46.108736247433377", "identifiers": [{"i": "GO:0005216", "l": "monoatomic ion channel activity", "d": ["Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678854", "l": "S1PR1 binds S1PR1 agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68694", "l": "3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21697", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797100", "l": "CCNK binds CDK13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000120", "l": "CBLIF binds RCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655483", "l": "USP1 autocleavage (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41260", "l": "L-tryptophan => (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46576", "l": "H(+) + NADPH + O2 + sitosterol = 2 H2O + NADP(+) + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102926", "l": "solanidine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25241", "l": "(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.26", "l": "\"(S)-ureidoglycine aminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008816", "l": "citryl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114683", "l": "Phosphorylation of Platelet Sec-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56312", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75427", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39648", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433936", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14319", "l": "H(+) + morphinone + NADH => morphine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024161", "l": "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22735", "l": "4-hydroxyphenylacetate + H(+) <=> 4-methylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24228", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) = 4-methylcatechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73482", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) <=> D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53838", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.21", "l": "\"ADP-sugar diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229283", "l": "LCNs bind lipids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26225", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) = abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.74", "l": "\"abieta-7,13-dien-18-al dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619756", "l": "NR1H2 binds ABCA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444511", "l": "Formation of MSH2:MSH3 Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60292", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.356", "l": "\"[histone H3]-lysine(27) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70004", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] => cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369028", "l": "ABCAs mediate lipid efflux (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0019840", "l": "isoprenoid binding", "d": ["Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613497", "l": "Unwinding DNA for the nascent transcript (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33527", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol = CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46386", "l": "24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13592", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate <=> 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:1901981", "l": "phosphatidylinositol phosphate binding", "d": ["Binding to phosphatidylinositol phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36009", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66616", "l": "Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55410", "l": "[phosphate](n+1) + CDP => [phosphate](n) + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.81", "l": "\"(-)-cyclopenine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388900", "l": "Neurotensin receptors can bind neurotensins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23380", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.141", "l": "\"N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047730", "l": "carnosine synthase activity", "d": ["Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114544", "l": "p115-RhoGEF activation of RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757578", "l": "ALB binds PREDN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205231", "l": "Dimerization of KIT upon SCF binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42686", "l": "L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693347", "l": "CRYM reduces P2C to PPCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33210", "l": "ATP + H(+) + L-glutamate + NADPH <=> ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23175", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140796", "l": "histone H3R8 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050436", "l": "microfibril binding", "d": ["Binding to a microfibril, any small fibril occurring in biological material."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28291", "l": "(2E,6E)-farnesyl diphosphate + H2O => (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709842", "l": "MAVS binds TOMM70 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68798", "l": "alpha-D-glucose + D-glucose => D-maltose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795460", "l": "SGK1 phosphorylates MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061579", "l": "N-acyl homoserine lactone synthase activity", "d": ["Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26226", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) => abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36432", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63747", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-1-N-beta-D-glucuronide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138459", "l": "WNT5A:FZD4 is endocytosed (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28572", "l": "diphosphate + L-seryl-5'-AMP => ATP + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149519", "l": "MMACHC decyanates CNCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46434", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876497", "l": "InlA binds CDH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18859", "l": "6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805640", "l": "AKT phosphorylates KAT6A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357445", "l": "PAK1-3 dimer disassociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39809", "l": "octadecanoate(out) => octadecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317530", "l": "SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004512", "l": "inositol-3-phosphate synthase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668831", "l": "CST complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37104", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737710", "l": "SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031220", "l": "maltodextrin phosphorylase activity", "d": ["Catalysis of the reaction: maltodextrin = glucose-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58245", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] => ADP-D-ribose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27933", "l": "(R)-4-phosphopantoate + ATP + beta-alanine <=> (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31485", "l": "H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP => soyasapogenol E + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72306", "l": "L-glutamate(in) + L-thyroxine(out) <=> L-glutamate(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67742", "l": "aceneuramate => N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41990", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3beta-hydroxy-5alpha-pregnane-20-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632993", "l": "PTEN gene transcription is stimulated by TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15921", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}, {"i": "EC:2.4.1.184", "l": "\"galactolipid galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42807", "l": "5,6,7,8-tetrahydromethanopterin + A <=> 7,8-dihydromethanopterin + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46569", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15104", "l": "H(+) + meso-2,6-diaminoheptanedioate <=> CO2 + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29459", "l": "beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66280", "l": "solanidine + UDP-alpha-D-glucose = H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168038", "l": "Collagen type XV restin release (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.915726484813547", "identifiers": [{"i": "GO:0004896", "l": "cytokine receptor activity", "d": ["Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63178", "l": "(2R)-ibuprofenoyl-CoA => (2S)-ibuprofenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60689", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) => (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58106", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36473", "l": "3,4,5-trihydroxybenzoate(in) + H(+)(in) => 3,4,5-trihydroxybenzoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430135", "l": "p-SLP-76 binds ADAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74480", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 => (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618107", "l": "ATP binding to HSP90 triggers conformation change (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48921", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20314", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP => 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39731", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681294", "l": "IL6R binds IL6R inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67900", "l": "glutarate + succinyl-CoA = glutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37110", "l": "H2O + N(7)-methyl-GMP <=> N(7)-methylguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19765", "l": "glycerol = 3-hydroxypropanal + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.30", "l": "\"glycerol dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043815", "l": "phosphoribosylglycinamide formyltransferase 2 activity", "d": ["Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0004457", "l": "lactate dehydrogenase activity", "d": ["Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004222", "l": "metalloendopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23926", "l": "2',3'-cGAMP + diphosphate => pppGp(2'-5')A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73242", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether <=> H(+) + ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322434", "l": "XIAP dissociates from ub-TLE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48170", "l": "N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755328", "l": "SARS-CoV-2 8 binds class I MHC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805785", "l": "AKT phosphorylates PHF20 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042658", "l": "MHC class II protein binding, via antigen binding groove", "d": ["Binding to the antigen binding groove of major histocompatibility complex class II molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.111", "l": "\"aqualysin 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690152", "l": "USP5 cleaves polyubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10166", "l": "H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77635", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53080", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396393", "l": "NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57223", "l": "GTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44062", "l": "2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045545", "l": "syndecan binding", "d": ["Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981539", "l": "C3b binds to cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806831", "l": "CYB5Rs reduce MetHb to HbA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0046857", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48598", "l": "decanoate + decanoylglycerol + H(+) => 1,2-didecanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74904", "l": "(2E)-2-butenoate + ATP + H(+) => (2E)-but-2-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030296", "l": "protein tyrosine kinase activator activity", "d": ["Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614591", "l": "Excess cysteine yields lanthionine and H2S (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65532", "l": "2-methylbutan-1-ol + hexanoyl-CoA = 2-methylbutyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27962", "l": "myo-inositol + pyrroloquinoline quinone = H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": [], "t": []}, {"i": "EC:1.1.5.n1", "l": "\"quinoprotein inositol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38215", "l": "D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902557", "l": "5'-adenylyl sulfate transmembrane transporter activity", "d": ["Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41977", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70481", "l": "TPI1 isomerizes GA3P to DHAP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.68", "l": "\"Ulp1 peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.534762107606241", "identifiers": [{"i": "GO:0032451", "l": "demethylase activity", "d": ["Catalysis of the removal of a methyl group from a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928627", "l": "EPHB phosphorylates TIAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14170", "l": "ATP + CoA + glutarate => ADP + glutaryl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654774", "l": "Transcription of PPP1R15A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374919", "l": "Noradrenaline clearance from the synaptic cleft (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28167", "l": "5-nitroanthranilate + H(+) + H2O => 5-nitrosalicylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112430", "l": "Formation of P-TEFb complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46228", "l": "apo-[peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36404", "l": "a cholesterol ester + H2O => a fatty acid + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047087", "l": "protopine 6-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + protopine = 6-hydroxyprotopine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36988", "l": "CMP + phosphate => alpha-D-ribose 1,5-bisphosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0016454", "l": "C-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209371", "l": "LGS binds to ARM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082356", "l": "HSF1-mediated gene expression (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23763", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018723", "l": "3-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71889", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide => GTP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097713", "l": "dolichol-phosphate-mannose synthase regulator activity", "d": ["Binds to and modulates the activity of dolichol-phosphate-mannose synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69890", "l": "Na(+)(out) + uridine(out) <=> Na(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55892", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 = a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36719", "l": "hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-hexacosenoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592310", "l": "Aggrecan degradation by ADAMTSs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244428", "l": "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71344", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) => chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16302", "l": "H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433542", "l": "Phosphorylation and activation of VAV1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681987", "l": "LC3 is cleaved by ATG4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75206", "l": "alpha,alpha-trehalose(out) + ATP + H2O <=> ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26281", "l": "Co-precorrin-5A + H2O = acetaldehyde + Co-precorrin-5B + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.12", "l": "\"cobalt-precorrin 5A hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67877", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine => 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008843", "l": "endochitinase activity", "d": ["Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849102", "l": "SRMS phosphorylates PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047546", "l": "2-hydroxypyridine 5-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O2 = 2,5-dihydroxypyridine + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10078", "l": "beta-D-galactose + D-glucose => H2O + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665871", "l": "ADRM1 binds 26S proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671993", "l": "CIT-3 binds DLG4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047896", "l": "formaldehyde transketolase activity", "d": ["Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714691", "l": "RAC3 binds ER effectors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70311", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29080", "l": "(R)-lactate + ubiquinone-8 => pyruvate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44401", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16244", "l": "an NDP-alpha-D-glucose + D-fructose <=> a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0022885", "l": "bacteriocin transmembrane transporter activity", "d": ["Enables the transfer of a bacteriocin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49436", "l": "cholate + deoxycholoyl-CoA = choloyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098872", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649735", "l": "Intrinsic nucleotide exchange on RAS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64337", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA => 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63942", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682010", "l": "ATG10:ATG12 binds ATG5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53548", "l": "prostaglandin J2 = Delta(12)-prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69270", "l": "an alkenyl isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkenimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60985", "l": "16-hydroxyhexadecanoate + NAD(+) => 16-oxohexadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23476", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:4.1.1.48", "l": "\"indole-3-glycerol-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77464", "l": "furan-3-carbaldehyde + hydrogen cyanide => (2S)-2-(furan-3-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950766", "l": "IL27RA dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16547", "l": "formate + oxalyl-CoA => formyl-CoA + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51188", "l": "nitric oxide + superoxide = peroxynitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180905", "l": "Association of Vpr with ANT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60630", "l": "A + H2O + progoitrin => AH2 + gluconapin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51895", "l": "H2O + N-acetylcadaverine <=> acetate + cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63766", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20955", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55988", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}, {"i": "EC:3.2.1.106", "l": "\"mannosyl-oligosaccharide glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16515", "l": "acetate + CO2 + H2O => (S)-lactate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332359", "l": "Active calmodulin binds CAMK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692408", "l": "NPR2 binds NPPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62326", "l": "(+)-malbrancheamide + FADH2 => (+)-malbrancheamide B + chloride + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77251", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331331", "l": "TP53 binds the PMAIP1 (NOXA) promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36424", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21714", "l": "benzaldehyde + glycine => L-threo-3-phenylserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40882", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046422", "l": "violaxanthin de-epoxidase activity", "d": ["Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39417", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21886", "l": "H(+) + sulfate + thiosulfate => H2O + trithionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051434", "l": "BH3 domain binding", "d": ["Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62572", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine = glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60824", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate = 2 AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031756", "l": "Edg-3 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-3 sphingosine 1-phosphate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052923", "l": "all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66503", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69837", "l": "(22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030145", "l": "manganese ion binding", "d": ["Binding to a manganese ion (Mn)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647632", "l": "CASP3 cleaves GSDME (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24144", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.57", "l": "\"isohexenylglutaconyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49587", "l": "D-erythrulose 1-phosphate <=> L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38771", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31264", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol => but-3-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40672", "l": "2-iminopropanoate + H2O => NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12446", "l": "(2E)-hexadecenal + H(+) + NADPH => hexadecanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210892", "l": "cya and lef bind to pagA(197-794):ANTXR2 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709360", "l": "H2O2 reduces MetHb (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36514", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14378", "l": "(3R)-3-hydroxy-L-aspartate => glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693243", "l": "RHOD translocates to the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085992", "l": "SUMOylation of DAXX with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047270", "l": "lipopolysaccharide glucosyltransferase II activity", "d": ["Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46416", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.26", "l": "\"acyl-[acyl-carrier-protein] 6-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83650", "l": "FasL:Fas binds FADD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161563", "l": "PGJ2 is isomerised to delta12-PGJ2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166015", "l": "Association of LBP with LPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004305", "l": "ethanolamine kinase activity", "d": ["Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050084", "l": "mannitol-1-phosphatase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64244", "l": "a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30237", "l": "2 H(+) + L-glutamate + NADH => H2O + L-glutamate 5-semialdehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12094", "l": "(R)-acetoin => (S)-acetoin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62471", "l": "3,4-dihydroxybenzoate + ATP + H(+) <=> 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53270", "l": "L-xylulose => L-ribulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50934", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65512", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 = 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678925", "l": "NR3C1 binds NR3C1 agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41758", "l": "1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45047", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 <=> 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50818", "l": "5alpha-androstan-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693012", "l": "TNFSF15 binds TNFRSF25 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40291", "l": "ATP + CoA + tetradecanedioate = AMP + diphosphate + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46365", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63210", "l": "5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + glyoxal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53794", "l": "benzothialdehyde + H2O2 => benzylthiol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75437", "l": "14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36324", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH => (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655241", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167087", "l": "Limited elongation of the HIV-1 transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140806", "l": "SERPINC1 binds SERPINC1 activators (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51936", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione = glutathione disulfide + hydroquinone", "d": [], "t": []}, {"i": "EC:1.8.5.7", "l": "\"glutathionyl-hydroquinone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632677", "l": "PTCH is internalized (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66426", "l": "ADP + H(+) + leukotriene B4(out) + phosphate => ATP + H2O + leukotriene B4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034524", "l": "2-hydroxyisophthalate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682598", "l": "ATM phosphorylates HERC2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64883", "l": "CDP + H2O <=> CMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44178", "l": "a 3-acyl-sn-glycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75051", "l": "chenodeoxycholate(out) = chenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40379", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624800", "l": "CDK1 phosphorylates LBR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0070576", "l": "vitamin D 24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of any form of vitamin D."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69144", "l": "agmatine + H2O + O2 = 4-guanidinobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54754", "l": "dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49754", "l": "CO2 + 2 H2O + NAD(+) + proviolacein => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209891", "l": "Dopamine is oxidised to noradrenaline (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71543", "l": "5-hydroxymethyl-dUMP in DNA + ATP = 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42858", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47252", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69437", "l": "7-oxopregnenolone + H(+) + NADPH => 7beta-hydroxypregnenolone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201685", "l": "Beta-catenin is released from the destruction complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200406", "l": "CPT1A,B transfers PALM to CAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43389", "l": "1D-myo-inositol 3,4-bisphosphate + H2O => 1D-myo-inositol 3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35639", "l": "(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29156", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) => 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067667", "l": "IL6 binds IL6R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168640", "l": "Ubiquitinated IkB is degraded (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672980", "l": "Dissociation of RAS:RAF complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21078", "l": "CO2 + succinate + uridine => 2'-deoxyuridine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55315", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070737", "l": "protein-glycine ligase activity, elongating", "d": ["Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996755", "l": "ZFPM proteins bind GATA proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66417", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O => ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40084", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071567", "l": "deUFMylase activity", "d": ["A thiol-dependent isopeptidase activity that cleaves UFM1 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15707", "l": "2 a ubiquinol + phenylglyoxylyl-CoA => 2 a ubiquinone + H2O + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.192", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64201", "l": "an N-(fatty acyl)-L-leucine + H2O => a fatty acid + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12960", "l": "an acetyl ester + H2O <=> acetate + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399952", "l": "Phosphorylation of LIMK-1 by PAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.383", "l": "\"ketol-acid reductoisomerase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42684", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}, {"i": "EC:3.5.1.118", "l": "\"gamma-glutamyl hercynylcysteine S-oxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66237", "l": "IC-asc-C9-CoA + O2 => H2O2 + IC-asc-DeltaC9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638845", "l": "CERK phosphorylates CERA to form C1P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77288", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654163", "l": "Activated FGFR4 binds PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0046997", "l": "oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin."], "t": []}, {"i": "EC:1.5.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52151", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose <=> an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65853", "l": "a 3-oxo-Delta(1)-steroid + H2O => a 1-hydroxy-3-oxo steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062072", "l": "H3K9me3 modified histone binding", "d": ["Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032427", "l": "GBD domain binding", "d": ["Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11166", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026544", "l": "Non-enzymatic hydrolysis hydrolyses 13(S),14(S)-epoxy-DHA to 7-epi-MaR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937419", "l": "CBR3 reduces DOX to DOXOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693609", "l": "ATM phosphorylates TP53 at S15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114264", "l": "Translocation of activated BAX to the mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672817", "l": "Active MTORC1 binds the ULK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662613", "l": "MT3 exchanges zinc for copper (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34268", "l": "acetyl-CoA + fumigaclavine B => CoA + fumigaclavine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21055", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23313", "l": "2 sucrose => 1(F)-beta-D-fructosylsucrose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804099", "l": "HMGB1 binds LTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64610", "l": "diphosphate + uridylyl-L-threonyl-[protein] => L-threonyl-[protein] + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45705", "l": "(E)-sinapyl alcohol + NADP(+) => (E)-sinapaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669250", "l": "PAK1 phosphorylates FLNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047772", "l": "carboxymethyloxysuccinate lyase activity", "d": ["Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15383", "l": "2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO => O2 + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64250", "l": "CoA + H(+) + N-decanoylglycine => decanoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12649", "l": "L-rhamnofuranose + NAD(+) = H(+) + L-rhamnono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24313", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822914", "l": "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37494", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51204", "l": "6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66825", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018555", "l": "phenanthrene dioxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67083", "l": "a very long-chain fatty acid(in) + ATP + H2O <=> a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194793", "l": "botC LC cleaves target cell SNAP25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050306", "l": "sucrose 1F-fructosyltransferase activity", "d": ["Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59800", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611721", "l": "β1-agonists bind ADRB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15777", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.40", "l": "\"guanidinodeoxy-scyllo-inositol-4-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0048403", "l": "brain-derived neurotrophic factor binding", "d": ["Binding to brain-derived neurotrophic factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28358", "l": "FAD + H(+) + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69263", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73261", "l": "eupatorin + H(+) + S-adenosyl-L-homocysteine => cirsiliol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51101", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106283", "l": "ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + ursodeoxycholate = 7-oxolithocholate + H+ + NADH."], "t": []}, {"i": "RHEA:42028", "l": "NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24339", "l": "a carboxylate + ATP + CoA <=> AMP + an acyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018825", "l": "triethanolamine lyase activity", "d": ["Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604834", "l": "SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34616", "l": "2-hydroxyethylphosphonate + O2 => H(+) + hydrogencarbonate + methylphosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757434", "l": "Acetylsalicylic acid dissolves (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534378", "l": "Hv1 Mediated H+ Permeability (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606789", "l": "ARSB hydrolyses DS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61557", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046175", "l": "Further sulfation on galactose residues produces KSPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139919", "l": "Translocation of BIM to mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40096", "l": "26-oxohexacosanoate + H2O + NAD(+) => 2 H(+) + hexacosanedioate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43916", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49303", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36744", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72671", "l": "eIF5B:GTP is hydrolyzed and released (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65084", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052909", "l": "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59719", "l": "D-maltopentaono-1,5-lactone + H2O <=> D-maltopentaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372542", "l": "Loading of dopamine into synaptic veiscles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10443", "l": "D-glucono-1,5-lactone + H2O <=> D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62915", "l": "H(+) + NADH + O2 + toralactone <=> 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77015", "l": "(S)-leucinol + H2O + NAD(+) = 1-hydroxy-4-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296043", "l": "Activation of HCN channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418856", "l": "Activation of Rac1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39325", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20685", "l": "galactitol + NAD(+) = H(+) + keto-D-tagatose + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.16", "l": "\"galactitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592240", "l": "Formation of NRF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429449", "l": "Syk activation leads to SLP-76 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38686", "l": "ATP + H2O + sphing-4-enine(in) <=> ADP + H(+) + phosphate + sphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203613", "l": "depalmitoylation of eNOS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72489", "l": "citrate(in) + phosphoenolpyruvate(out) => citrate(out) + phosphoenolpyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696268", "l": "RND3 binds effectors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34521", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP => N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26563", "l": "2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675815", "l": "PI4P transports from the Golgi membrane to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53750", "l": "a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44637", "l": "2,4-dinitroanisole + H2O => 2,4-dinitrophenol + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019706", "l": "protein-cysteine S-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64574", "l": "(2Z,6Z)-farnesyl diphosphate + diphosphate => isopentenyl diphosphate + neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64067", "l": "(1R,2R)-pseudoephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35172", "l": "H(+)(out) + novobiocin(in) => H(+)(in) + novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.239", "l": "\"carnitine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018700", "l": "2-chloro-N-isopropylacetanilide reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382054", "l": "PDGF binds to extracellular matrix proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19758", "l": "(3R)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047553", "l": "2-oxoglutarate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.348834789597348", "identifiers": [{"i": "GO:0016849", "l": "phosphorus-oxygen lyase activity", "d": ["Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond."], "t": []}, {"i": "EC:4.6.-.-", "l": "\"Phosphorus-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30646", "l": "phosphate + S-methyl-5'-thioinosine <=> hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35697", "l": "(2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH => (3S)-versiconol acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46864", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904599", "l": "advanced glycation end-product binding", "d": ["Binding to advanced glycation end-product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48247", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66875", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67979", "l": "all-trans-neurosporene <=> beta-zeacarotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164509", "l": "Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58451", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65437", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30963", "l": "7,9,9'-tri-cis-neurosporene + a quinone = 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39221", "l": "(3R)-hydroxyoctacosanoyl-CoA + NADP(+) => 3-oxooctacosanyol-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18469", "l": "an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.68", "l": "\"glutamine N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75893", "l": "CoA + pseudomonic acid C--holothin => holothin + pseudomonoyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798528", "l": "S100A8:S100A9 binds Mn2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199518", "l": "C3d-complexed antigen binds to complement receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59906", "l": "2 H(+) + NADPH + octanoate => H2O + NADP(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-688137", "l": "RIP2 is K63 polyubiquitinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25350", "l": "D-tyrosyl-tRNA(Tyr) + H2O <=> D-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631885", "l": "PRDX1 overoxidizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008127", "l": "quercetin 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404134", "l": "RBP4:atROL binds TTR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55180", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 = 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210298", "l": "Interaction of DAP12 and KIR3DS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57517", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62185", "l": "peregrinol diphosphate => diphosphate + labd-13(16),14-diene-9-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655343", "l": "Activated FGFR2 mutants bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68914", "l": "DNA polymerase alpha:primase binds at the origin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943811", "l": "MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68598", "l": "beta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27950", "l": "L-phenylalanine(in) = L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788622", "l": "p-Y-STATs dimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16869", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}, {"i": "EC:1.13.11.33", "l": "\"arachidonate 15-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61450", "l": "11a-hydroxytigecycline + H2O + NADP(+) => H(+) + NADPH + O2 + tigecycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20257", "l": "3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.17", "l": "\"3-methyleneoxindole reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36682", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70485", "l": "a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58263", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] <=> ADP-D-ribose + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64466", "l": "H(+) + H2O2 + L-topaquinyl-[protein] => L-tyrosyl-[protein] + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006490", "l": "MECP2 binds the GRIN2A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909721", "l": "Translocation of ISGF3 complex to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757462", "l": "Hydroxyl radicals oxidize ST to 2,3-DHBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66971", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36085", "l": "1-O-alkyl-sn-glycerol + H(+) + phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37008", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23200", "l": "H2O + N(6)-methyl-L-lysine + O2 = formaldehyde + H2O2 + L-lysine", "d": [], "t": []}, {"i": "EC:1.5.3.4", "l": "\"N(6)-methyl-lysine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52592", "l": "deoxycholoyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72894", "l": "acetylcholine(out) + 2 H(+)(in) <=> acetylcholine(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41927", "l": "(3R)-hydroxyoctadecanoyl-[ACP] <=> (2E)-octadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16452", "l": "acetyl-CoA + kanamycin B <=> CoA + H(+) + N(6')-acetylkanamycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793666", "l": "MDM2 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46284", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74728", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH => 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76961", "l": "2-methylbutanal + H(+) + NADPH + NH4(+) => 2-methylbutanamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42645", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] => diphosphate + holo-[malonate decarboxylase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45200", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.258", "l": "\"5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32614", "l": "(6E)-8-hydroxygeranial + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840949", "l": "ARSA removes sulfate from SM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68808", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O = alpha-D-glucose + D-fructose", "d": [], "t": []}, {"i": "EC:3.2.1.219", "l": "\"palatinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0033283", "l": "ATPase-coupled organic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53137", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018557", "l": "1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675790", "l": "MTORC1 dissociates from ULK complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033705", "l": "GDP-4-dehydro-6-deoxy-D-mannose reductase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728729", "l": "TAS1R2:TAS1R3:sweet compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R2:TAS1R3:sweet compound, GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64195", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine <=> (9Z)-octadecenoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198669", "l": "p38MAPK phosphorylates MSK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54743", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27923", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055131", "l": "C3HC4-type RING finger domain binding", "d": ["Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021450", "l": "PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74986", "l": "Elongation of pre-rRNA transcript (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47947", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geranyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24983", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68060", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74909", "l": "(2E)-butenoyl-[ACP] + AMP + H(+) => (2E)-but-2-enoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57532", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) = a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813740", "l": "GDE1 hydrolyzes GroPIns (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198669", "l": "p38MAPK phosphorylates MSK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19011", "l": "a carboxylate + H(+) + pyruvate => a 3-acylpyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876868", "l": "ECE1 cleaves EDN1(53-90) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54994", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+) => 3 A + FMN + H2O + L-glutamate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173709", "l": "C7 binds C5b:C6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102764", "l": "6-deoxotyphasterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60883", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32348", "l": "2 S-adenosyl-L-methionine + tricetin => 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483099", "l": "PA translocates from the outer to the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74718", "l": "Internalisation of the insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018744", "l": "limonene-1,2-epoxide hydrolase activity", "d": ["Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50613", "l": "decanal + NADP(+) => (2E)-decenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.-", "l": "\"Other isomerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39487", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA = (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56445", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333678", "l": "CPNEs bind PL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005316", "l": "high-affinity inorganic phosphate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35014", "l": "D-fucose(in) + H(+)(in) <=> D-fucose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65373", "l": "a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate => a globoside MSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11689", "l": "ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30881", "l": "2 H(+) + NADH + propynoate => H2O + NAD(+) + prop-2-ynal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0055105", "l": "ubiquitin-protein transferase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36474", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) <=> 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425861", "l": "Activation of Protein Kinase C novel isoforms (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77249", "l": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate => H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648017", "l": "EML4 binds to microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11872", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.5", "l": "\"corticosterone 18-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264435", "l": "Dissociation of the COP1-p53 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24085", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373746", "l": "SEMA4D interacts with CD45 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22126", "l": "acetate + ajmaline + H(+) => 17-O-acetylajmaline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14790", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13993", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.22", "l": "\"(S)-3-amino-2-methylpropionate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31644", "l": "mycinamicin VI + S-adenosyl-L-methionine => H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373734", "l": "Nephrin interacts with Podocin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34977", "l": "(R)-pantothenate(out) => (R)-pantothenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50796", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38984", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.170", "l": "\"isoflavone 7-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70897", "l": "H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein] => N-terminal L-cysteinyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042469", "l": "versicolorin reductase activity", "d": ["Catalysis of the reduction of versicolorin A to sterigmatocystin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16176", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine <=> (S)-norcoclaurine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36419", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33130", "l": "H2O + salicin-6-phosphate <=> beta-D-glucose 6-phosphate + salicyl alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69053", "l": "RFC binding displaces Pol Alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14949", "l": "A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": [], "t": []}, {"i": "EC:1.3.99.19", "l": "\"quinoline-4-carboxylate 2-oxidoreductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203567", "l": "palmitoylation of eNOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39268", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63037", "l": "H2O + octadecanamide => NH4(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41646", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39321", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001962", "l": "alpha-1,3-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.4", "l": "\"nicotine 6-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75229", "l": "H(+) + L-xylonate => H2O + L-xylono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37125", "l": "CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine => sphing-4-enine + tetracosenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388596", "l": "Melanocortin receptors bind melanocortins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858428", "l": "FCAMR binds IgA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.-", "l": "\"In C-halide compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607734", "l": "PKC-delta translocates to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692539", "l": "HRH1 binds HRH1 inverse agonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975633", "l": "atROL binds to RBP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14643", "l": "biuret + CO2 => cyanurate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9623384", "l": "α1-agonists bind ADRA1A,B,D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205244", "l": "Recruitment of CBL to KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38476", "l": "L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56209", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76838", "l": "ethylamine + H2O + NAD(+) <=> acetaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32369", "l": "4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate => 4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43766", "l": "AMP + chenodeoxycholoyl-CoA + diphosphate => ATP + chenodeoxycholate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109857", "l": "MAP2K1 binds MAPK3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58691", "l": "NADH + O2 + rifamycin SV <=> H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30036", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 => benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193703", "l": "IKKbeta is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48222", "l": "(2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047820", "l": "D-glutamate cyclase activity", "d": ["Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177479", "l": "Axonal transport of NGF:Trk complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12744", "l": "ADP + H(+) + H2O <=> IDP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28843", "l": "choline(in) + H(+)(in) = choline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22708", "l": "H2O + S-acylglutathione = a carboxylate + glutathione + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.7", "l": "\"glutathione thiolesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266557", "l": "Factor I cleaves iC3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43687", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140594", "l": "xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity", "d": ["Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52488", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45439", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46579", "l": "H(+) + NADPH + O2 + sitosterol <=> 2 H2O + NADP(+) + stigmasterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60782", "l": "CO2 + gibberellin A24 + H2O + succinate => 2-oxoglutarate + gibberellin A15 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12736", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.099579202379552", "identifiers": [{"i": "GO:0022853", "l": "active monoatomic ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58687", "l": "FAD + 2 H(+) + NADPH + O2 <=> FADH2-C4alpha-hydroperoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74459", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16281", "l": "ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.88", "l": "\"dihydrostreptomycin-6-phosphate 3'alpha-kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654511", "l": "FGFRL1 dimer binds FGFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327746", "l": "FN1 aggregation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25484", "l": "(2E)-geranyl diphosphate = (1S,4R)-camphene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.117", "l": "\"(-)-camphene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701562", "l": "CD274 gene expression downstream of ALK signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.-", "l": "\"Enzymes altering nucleic acid conformation\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39223", "l": "(3R)-hydroxyoctacosanoyl-CoA = (2E)-octacosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71586", "l": "L-histidine(in) + Na(+)(in) <=> L-histidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645598", "l": "RRAGC,D hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75126", "l": "(1R)-(1-hydroxyethyl)phosphonate + O2 <=> acetate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56796", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] = adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034545", "l": "fumarylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11316", "l": "an aliphatic aldoxime = a nitrile + H2O", "d": [], "t": []}, {"i": "EC:4.8.1.2", "l": "\"aliphatic aldoxime dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24593", "l": "CTP + H(+) + phosphoethanolamine => CDP-ethanolamine + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395320", "l": "Latent TGF-beta-1 binds integrins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.75", "l": "\"very-long-chain acyl-lipid omega-9 desaturase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140164", "l": "Golgi transport complex binding", "d": ["Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31161", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110440", "l": "Autophosphorylation of DINR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76603", "l": "(12Z)-10-hydroxyoctadecenoate + H2O = 10,13-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653974", "l": "Ragulator binds Rag dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61866", "l": "A + probetaenone I => AH2 + dehydroprobetaenone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374696", "l": "Phosphorylation of L1 by p90rsk (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61491", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69313", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61079", "l": "(-)-minovincinine + acetyl-CoA <=> (-)-echitovenine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879274", "l": "acetylglucosamine-inositol-phosphate is dephosphorylated (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047768", "l": "carboxy-cis,cis-muconate cyclase activity", "d": ["Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42987", "l": "(+)-copalyl diphosphate <=> diphosphate + pimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013004", "l": "RHOA binds effectors at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53711", "l": "(2E)-decenoyl-CoA + NADP(+) <=> (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602672", "l": "Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45505", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49027", "l": "L-tryptophan + O2 <=> 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60956", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18477", "l": "2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.14", "l": "\"2,3-dihydroxybenzoate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620975", "l": "MLKL binds PIPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74450", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21235", "l": "L-histidine <=> NH4(+) + trans-urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201630", "l": "Caspase-mediated cleavage of Acinus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14343", "l": "2-hydroxy-3-oxoadipate + CO2 => 2-oxoglutarate + glyoxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851979", "l": "BTNL9 binds immune cell surfaces (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12674", "l": "an aliphatic amide => a nitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.10", "l": "\"magnesium dechelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46888", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.48", "l": "\"3-deoxy-alpha-D-manno-octulosonate 8-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210444", "l": "L-Glutamate loading of synaptic vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54664", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin", "d": [], "t": []}, {"i": "EC:5.4.99.65", "l": "\"pre-alpha-onocerin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102265", "l": "tRNA-dihydrouridine47 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900743", "l": "NOTCH1 HD+PEST domain mutants bind JAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190258", "l": "FGFR2c binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36051", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose", "d": [], "t": []}, {"i": "EC:3.2.1.185", "l": "\"non-reducing end beta-L-arabinofuranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66615", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA <=> methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682026", "l": "MRN bound to shortened telomeres activates ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37182", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate <=> (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212614", "l": "Glutamine transport from astrocytes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67222", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65182", "l": "A + H2O + preaustinoid A => AH2 + O2 + protoaustinoid B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56540", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762345", "l": "PREDN:ALB dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174121", "l": "Association of Securin with Cdc20:APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981606", "l": "Myoglobin binds oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48171", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine <=> N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57939", "l": "H2O + isopyridoxal + NAD(+) <=> 5-pyridoxate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23527", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol <=> an alkyl cinnamate + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25304", "l": "7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+) => 7,8-dihydroneopterin 3'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58703", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin <=> FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50573", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.36", "l": "\"alcohol dehydrogenase (nicotinoprotein)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686430", "l": "MUS81 binds EME1, EME2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41958", "l": "cytidine 2'-phosphate + H(+) => 2',3'-cyclophospho-CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58942", "l": "all-trans-lycopaoctaene + diphosphate + NAD(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42631", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA <=> 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65312", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.293", "l": "\"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43637", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) => 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43849", "l": "[thioredoxin]-dithiol + arsenate + H(+) => [thioredoxin]-disulfide + arsenite + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59805", "l": "L-phenylalanine => D-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68526", "l": "beta-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9737780", "l": "MTTP binds lomitapide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53152", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51930", "l": "(S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH => H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21630", "l": "acetate + androst-4-ene-3,17-dione + H2O + NADP(+) => 17alpha-hydroxyprogesterone + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026366", "l": "NTF3-bound NTRK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34951", "l": "3-hydroxypropanoate(out) = 3-hydroxypropanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021596", "l": "Membrane estrogen receptors bind SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29759", "l": "octanoate(in) = octanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035615", "l": "clathrin adaptor activity", "d": ["Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0072320", "l": "volume-sensitive chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646468", "l": "mTORC1 binds RHEB:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69320", "l": "glucoerucin + H2O = (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592240", "l": "Formation of NRF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67044", "l": "A + asnovolin H = AH2 + chermesin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684261", "l": "nsp4 is glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701548", "l": "PRDM1 gene expression downstream of ALK signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697051", "l": "RTC binds NRTIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11772", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.220", "l": "\"6-pyruvoyltetrahydropterin 2'-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791155", "l": "Expression of EDEM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693111", "l": "RHOF auto-activates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68886", "l": "3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-hydroxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050527", "l": "poly(3-hydroxyoctanoate) depolymerase activity", "d": ["Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.50", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56156", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56272", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol = 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033441", "l": "AAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168891", "l": "Binding of NS1 to dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10353", "l": "an N-acetylarylalkylamine + H2O => acetate + an aralkylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26505", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:1990760", "l": "osmolarity-sensing monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848023", "l": "Activated PTK6 binds STAP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74343", "l": "O-hexanoyl-(R)-carnitine(in) = O-hexanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19385", "l": "UDP-alpha-D-glucose + vomilenine = H(+) + raucaffricine + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.219", "l": "\"vomilenine glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52375", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928625", "l": "PAKs autophosphorylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856189", "l": "TNFSF8 binds TNFRSF8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66493", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532603", "l": "Nephrin mediated activation of N-WASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714481", "l": "RAC2 binds effectors at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018550", "l": "tetrachloro-p-hydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32146", "l": "L-arginine(in) <=> L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73596", "l": "dCMP + H2O => dUMP + NH4+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696268", "l": "RND3 binds effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210298", "l": "Interaction of DAP12 and KIR3DS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56493", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449087", "l": "CD4 binds Interleukin-16 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21403", "l": "2-oxoglutarate + CoA + NADP(+) <=> CO2 + NADPH + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850945", "l": "Casein kinase II phosphorylates PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52838", "l": "H2O + indoxyl + NAD(+) => H(+) + indole + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692376", "l": "BCL2 binds BCL2 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63366", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15344", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide <=> ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31930", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11253", "l": "H(+) + hydroxylamine + L-asparagine => beta-L-aspartylhydroxamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-706479", "l": "TAK1 is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48867", "l": "2-methylpropan-1-amine + FADH2 + O2 <=> FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11766", "l": "methylamine + urea => H2O + methylguanidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12775", "l": "CO2 + dihydroclavaminate + H2O + succinate => 2-oxoglutarate + O2 + proclavaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48699", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69999", "l": "L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948775", "l": "MKRN1 polyubiquitinates PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668735", "l": "RAC1:GTP binds NOX3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42433", "l": "3-hydroxy-cis,cis-muconate => maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17297", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.7.3", "l": "\"2-oxoglutarate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928656", "l": "gamma-secretase cleaves EPHB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429767", "l": "Passive I- efflux mediated by SMCT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253343", "l": "WWOX binds ERBB4s80 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60887", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31393", "l": "all-trans-4,4'-diapolycopene + 4 FADH2 => 15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871260", "l": "YAP1 binds TEAD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781832", "l": "Defective MPI does not  isomerize Fru6P to Man6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18019", "l": "CO2 + indole-3-acetaldehyde => H(+) + indole-3-pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008872", "l": "glucarate dehydratase activity", "d": ["Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57238", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20659", "l": "4-chlorophenylacetate + NH4(+) => 4-chlorophenylacetonitrile + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.21", "l": "\"keratan sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047841", "l": "dehydrogluconokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0097364", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27483", "l": "acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176517", "l": "SULTs transfer (SO4)2- group to PREG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018497", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity", "d": ["Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0106292", "l": "superoxide-generating NADPH oxidase activity", "d": ["Catalysis of the reaction: NADPH + 2 O2 = H+ + NADP+ + 2 superoxide."], "t": []}, {"i": "RHEA:63180", "l": "NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47307", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106334", "l": "3'-deoxyribose phosphate lyase activity", "d": ["Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate."], "t": []}, {"i": "RHEA:65764", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O = (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451377", "l": "Interaction of IQGAP1 with nephrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028519", "l": "NTRK2-activated PI3K generates PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44855", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59085", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48738", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198813", "l": "GSTO dimers reduce DeHA to AscH- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38830", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610722", "l": "CK1 phosphorylates p-GLI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17770", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17792", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine <=> (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59612", "l": "beta-alanyl-L-ornithine + H2O = beta-alanine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24515", "l": "L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62365", "l": "FMN-N(5)-peroxide + thymine => (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30031", "l": "(S)-muconolactone = cis,cis-muconate + H(+)", "d": [], "t": []}, {"i": "EC:5.5.1.1", "l": "\"muconate cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59110", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol => chenodeoxycholate + octyl beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090483", "l": "phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466370", "l": "NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57290", "l": "a guanosine in RNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187828", "l": "Translocation of p21 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72927", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015125", "l": "bile acid transmembrane transporter activity", "d": ["Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.253", "l": "\"baicalein 7-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031857", "l": "type 1 parathyroid hormone receptor binding", "d": ["Binding to a type 1 parathyroid hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18222", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57803", "l": "2,3-dinitrotoluene + NADH + O2 <=> 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56314", "l": "3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate => 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74393", "l": "methylamine(in) => methylamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18845", "l": "(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38043", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.11", "l": "\"acyl-[acyl-carrier-protein] 4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75268", "l": "D-arabinose + NADP(+) => D-arabinono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084501", "l": "Collagen type VII binds collagen type IV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709787", "l": "SARS-CoV-1 9b binds TOMM70 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12817", "l": "2,3-dihydrobiochanin A + NADP(+) = biochanin A + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.46", "l": "\"biochanin-A reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212432", "l": "Formation of DRIP coactivator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11345", "l": "an N-acylneuraminate + CTP => a CMP-N-acyl-beta-neuraminate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972964", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74281", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9623384", "l": "α1-agonists bind ADRA1A,B,D (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043904", "l": "isochorismate pyruvate lyase activity", "d": ["Catalysis of the reaction: isochorismate = salicylate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875183", "l": "CBL monoubiquitinates activated MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052918", "l": "dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018658", "l": "salicylate 1-monooxygenase activity", "d": ["Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11538", "l": "glycine betaine + H(+) + 2 H2O2 => choline + H2O + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49581", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate => cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18707", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26054", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69826", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47684", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate = [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.333", "l": "\"1,2-beta-oligoglucan phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49743", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38163", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856951", "l": "PP2A demethylation by PPME1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0000166", "l": "nucleotide binding", "d": ["Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379980", "l": "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.6", "l": "\"AMP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976801", "l": "Complement factor I complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251942", "l": "Hikeshi binds HSP70s:ATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66721", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) => ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41793", "l": "holo-[ACP] + malonyl-CoA => CoA + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74066", "l": "2-aminoisobutanoate(out) + L-alanine(in) <=> 2-aminoisobutanoate(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73150", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) <=> adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48913", "l": "a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11319", "l": "an aliphatic aldoxime <=> a nitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29514", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-valencene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74258", "l": "XDH oxidizes xanthine to form urate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31651", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30583", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide = 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2752115", "l": "SPP1 (osteopontin) binds CD44 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871227", "l": "RET binds GFRA4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23414", "l": "acetate + putrescine => H2O + N-acetylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809309", "l": "MTMR6 binds MTMR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0045512", "l": "interleukin-26 binding", "d": ["Binding to interleukin-26."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76865", "l": "benzaldehyde + H(+) + NADH + NH4(+) => benzylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690196", "l": "USP8 deubiquitinates RNF128 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986943", "l": "MECP2 binds MET gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72422", "l": "(E)-4-coumarate + ATP + H(+) <=> (E)-4-coumaroyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785668", "l": "Defective LARGE does not transfer Xyl from UDP-Xyl to GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169402", "l": "ISGylation of E2 conjugating enzymes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59611", "l": "beta-alanyl-L-lysine + H2O <=> beta-alanine + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45393", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018859", "l": "4-hydroxybenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49454", "l": "6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32757", "l": "apigenin + CO2 + H(+) + H2O + succinate => (2S)-naringenin + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264435", "l": "Dissociation of the COP1-p53 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30547", "l": "(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932599", "l": "CALB1 binds 4xCa2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69136", "l": "2 H2O + 2 O2 + spermine = 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043212", "l": "carbohydrate-exporting ABC transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.7", "l": "\"deoxyribonuclease V\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50219", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50491", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033451", "l": "GUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUA codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35246", "l": "ADP + H(+) + thiamine diphosphate <=> adenosine thiamine triphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28574", "l": "H(+)(in) + sulfate(in) = H(+)(out) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070553", "l": "nicotinic acid receptor activity", "d": ["Combining with nicotinic acid to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013108", "l": "GDIs block activation of RHOC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033509", "l": "USP9X binds Ub:PEX5L (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227753", "l": "Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615937", "l": "TPNO/KPNB1 (transportin/importin beta) sequester the Nup107-160 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217097", "l": "Formation of the Rad17-RFC alternate clamp-loader complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333051", "l": "RPA1 binds HSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33819", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": [], "t": []}, {"i": "EC:5.3.3.19", "l": "\"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18858", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658435", "l": "RAS GAPs bind RAS:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832988", "l": "Expression of SOX2 in posterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48647", "l": "prostaglandin H2 <=> (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33529", "l": "CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate => acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22586", "l": "Fe(2+) + protoporphyrin IX => 2 H(+) + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25072", "l": "3-hydroxybenzoyl-CoA + AMP + diphosphate => 3-hydroxybenzoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726621", "l": "PGR binds PGR antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53047", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68537", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24248", "l": "glyoxylate + L-alanine = glycine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15078", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine => (R)-pantetheine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70238", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15260", "l": "D-threonine <=> acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76691", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419334", "l": "Melatonin receptors can bind melatonin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050332", "l": "thiamine pyridinylase activity", "d": ["Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31954", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37964", "l": "galactitol + NAD(+) => D-galactose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9737780", "l": "MTTP binds lomitapide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810937", "l": "Lamellar bodies bind the early cornified envelope (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222376", "l": "NOX2 generates superoxide from oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047827", "l": "D-lysopine dehydrogenase activity", "d": ["Catalysis of the reaction: D-lysopine + H2O + NADP+ = L-lysine + H+ + NADPH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36318", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH <=> CoA + hexadecan-1-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390912", "l": "HRH1 binds hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61472", "l": "a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.291", "l": "\"sphingoid base N-palmitoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182594", "l": "Association of INK4 family proteins with CDK4/6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693250", "l": "RHOD binds effectors at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46045", "l": "(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16322", "l": "(S)-indan-1-ol + NADP(+) => H(+) + indan-1-one + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306876", "l": "NLRP3 activation by small molecules (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45461", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047317", "l": "N6-acetyl-beta-lysine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69714", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-glucose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40677", "l": "2-aminobut-2-enoate + H2O => L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0035596", "l": "methylthiotransferase activity", "d": ["Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204813", "l": "Interaction of Tie2 and Grb14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458485", "l": "RALA hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169046", "l": "Degradation of TGF-beta receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001605", "l": "adrenomedullin receptor activity", "d": ["Combining with adrenomedullin to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696997", "l": "USP24 deubiquitinates DDB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59795", "l": "H2O + NADP(+) + yersinopine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011748", "l": "IL9R binds JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38052", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA => 1-butanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840408", "l": "OMA1 cleaves DELE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018808", "l": "RAC3 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54295", "l": "ATP + L-threonyl-[protein] <=> 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082356", "l": "HSF1-mediated gene expression (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59181", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O => 2 AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15384", "l": "O2 + quercetin <=> 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21956", "l": "UDP-alpha-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": [], "t": []}, {"i": "EC:2.4.1.105", "l": "\"vitexin beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011598", "l": "DOCKs bind to RhoGEFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43223", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46932", "l": "2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.35", "l": "\"2-epi-5-epi-valiolone 7-phosphate 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74745", "l": "3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3878123", "l": "Initiation of SAHF formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20449", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.36", "l": "\"chloridazon-catechol dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097256", "l": "phenyllactate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663511", "l": "BIL binds GSTA1, FABP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43757", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32699", "l": "(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.123", "l": "\"beta-sesquiphellandrene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647977", "l": "ICMT methylates S-Farn RAS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2574845", "l": "AJUBA binds centrosome-associated AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047554", "l": "2-pyrone-4,6-dicarboxylate lactonase activity", "d": ["Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34162", "l": "acetyl-CoA + UDP-N-acetylbacillosamine <=> CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784189", "l": "JAKs bind LIFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102354", "l": "11-cis-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013021", "l": "GDIs block activation of RHOB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102208", "l": "2-polyprenyl-6-hydroxyphenol methylase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949580", "l": "F1Fo ATP synthase dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.64", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399712", "l": "Activation of Ca permeable AMPA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72337", "l": "3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42120", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031073", "l": "cholesterol 26-hydroxylase activity", "d": ["Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047734", "l": "CDP-glycerol diphosphatase activity", "d": ["Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209840", "l": "Two DITs combine to form thyroxine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3240957", "l": "Formation of PRC2-EZH2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64575", "l": "isopentenyl diphosphate + neryl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35612", "l": "menadiol + 2 O2 => 2 H(+) + menadione + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607756", "l": "TRAF6 oligomer autoubiquitinates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855190", "l": "I(1,4,5)P3 transports from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.119", "l": "\"kallikrein 13\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031738", "l": "XCR1 chemokine receptor binding", "d": ["Binding to a XCR1 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38998", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40314", "l": "hexanoyl-CoA + O2 <=> (2E)-hexenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632652", "l": "Hh-Npp binds CDON and PTCH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10335", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005384", "l": "manganese ion transmembrane transporter activity", "d": ["Enables the transfer of manganese (Mn) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39255", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35277", "l": "3-oxooctadecanoyl-CoA + H(+) + NADH => 3-hydroxyoctadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042498", "l": "diacyl lipopeptide binding", "d": ["Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035718", "l": "macrophage migration inhibitory factor binding", "d": ["Binding to the cytokine, macrophage migration inhibitory factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58910", "l": "C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+) => 7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51818", "l": "AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23680", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.15", "l": "\"nucleoside-triphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23337", "l": "2 H(+) + H2O2 + 2 iodide => diiodine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17042", "l": "adenosine 5'-phosphosulfate + H2O => AMP + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9035227", "l": "TXN2 binds CysS248-MPST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31153", "l": "2-oxobutanoate + L-selenocysteine + NH4(+) => H2O + L-selenocystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875523", "l": "MET binds TNS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20696", "l": "2 H(+) + 2 superoxide = H2O2 + O2", "d": [], "t": []}, {"i": "EC:1.15.1.1", "l": "\"superoxide dismutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785762", "l": "IL13RA1 binds TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65468", "l": "1-propanol + acetyl-CoA = CoA + propyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56001", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733545", "l": "Bile salts and acids bind ALB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10337", "l": "citrate => D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53452", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47492", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0036041", "l": "long-chain fatty acid binding", "d": ["Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237160", "l": "MTA is cleaved and phosphorylated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31992", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquithujene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42006", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33166", "l": "beta-nicotinamide D-riboside(in) <=> beta-nicotinamide D-riboside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60300", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675947", "l": "TNFSF18 binds TNFRSF18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72647", "l": "1,6-dihydroxyphenazine + NADPH + O2 = 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64842", "l": "CoA + phenethyl benzoate => 2-phenylethanol + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175108", "l": "Target DNA binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000433", "l": "SUMOylation of PML with SUMO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391211", "l": "Trace amine-associated receptors can bind trace amines (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51096", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685318", "l": "BCDX2 complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49072", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.14.21", "l": "\"dibenzothiophene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138459", "l": "WNT5A:FZD4 is endocytosed (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52086", "l": "13-hydroxy-octadecanoate + H(+) + octadecanoate => 13-octadecanoyloxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5631885", "l": "PRDX1 overoxidizes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693608", "l": "Initial resection of double-strand break ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66069", "l": "4-methyl-2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047094", "l": "3-hydroxyphenylacetate 6-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46530", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44119", "l": "eicosan-1-ol + hexadecanoyl-CoA <=> CoA + eicosanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15139", "l": "H(+) + keto-L-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71542", "l": "H(+)(out) + 2 nitrate(out) <=> H(+)(in) + 2 nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23948", "l": "4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:1.1.1.61", "l": "\"4-hydroxybutyrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18659", "l": "3-hydroxypyruvate + H(+) + NADPH => (R)-glycerate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935766", "l": "miR-378 binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14400", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (4Z)-2-oxohept-4-enedioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28562", "l": "D-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.151319539368089", "identifiers": [{"i": "GO:1901505", "l": "carbohydrate derivative transmembrane transporter activity", "d": ["Enables the transfer of carbohydrate derivative from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632759", "l": "TP53 binds the SCO2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004397", "l": "histidine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-histidine = urocanate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621352", "l": "CLEC6A binds alpha-mannan in fungal cell walls (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62291", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate <=> (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46007", "l": "2-methylpropanal + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454689", "l": "14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047431", "l": "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H+ = 5-hydroxy-6-methylpyridine-3-carboxylate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17649", "l": "acetyl-[ACP] + malonate = acetate + malonyl-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.187", "l": "\"acetyl-S-ACP:malonate ACP transferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67235", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) <=> (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70418", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O <=> (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47432", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75269", "l": "D-arabinono-1,5-lactone + H(+) + NADPH => D-arabinose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35005", "l": "L-fucose(out) => L-fucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62776", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18756", "l": "[protein]-dithiol + NADP(+) <=> [protein]-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76227", "l": "(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate = (indol-3-yl)acetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70692", "l": "ornithine => putrescine + CO2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192061", "l": "CYP46A1 24-hydroxylates CHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445448", "l": "HHIP binds Hedgehog (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72488", "l": "citrate(out) + phosphoenolpyruvate(in) => citrate(in) + phosphoenolpyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55399", "l": "(R)-carnitine + H(+) + NADH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45269", "l": "4'-hydroxyechinenone + AH2 + O2 => 4',4'-dihydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299338", "l": "Activation of TRESK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19137", "l": "17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.11", "l": "\"estradiol 6beta-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28720", "l": "adenine(in) + H(+)(in) => adenine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983150", "l": "Proteasomal cleavage of substrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31505", "l": "4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39519", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.314050959231352", "identifiers": [{"i": "GO:0019783", "l": "ubiquitin-like protein peptidase activity", "d": ["An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222655", "l": "AhpD reactivates AhpC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990827", "l": "deaminase binding", "d": ["Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31959", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38633", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45068", "l": "(R)-carnitine + an acyl-CoA = CoA + O-acyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11046", "l": "a halide anion + glycolate + H(+) => a haloacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17914", "l": "H2O + NAD(+) + nitrite => H(+) + NADH + nitrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070674", "l": "hypoxanthine dehydrogenase activity", "d": ["Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+."], "t": []}, {"i": "REACT:R-HSA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20017", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H(+)", "d": [], "t": []}, {"i": "EC:1.12.98.2", "l": "\"5,10-methenyltetrahydromethanopterin hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015330", "l": "high-affinity glutamine transmembrane transporter activity", "d": ["Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76746", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecane <=> 7-tetradecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332356", "l": "CAMK2 binds MAP3K7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64624", "l": "(2E)-geraniol + acetyl-CoA = (2E)-geranyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446077", "l": "BP230 interacts with keretin K5/K14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64001", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42371", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008331", "l": "high voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.2", "l": "\"deoxyribonuclease IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050333", "l": "thiamine triphosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54034", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+) => (6R)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23086", "l": "7-methyl-3-oxooct-6-enoyl-CoA + acetate => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008281", "l": "sulfonylurea receptor activity", "d": ["Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65044", "l": "4-cyanobenzyl alcohol + NAD(+) = 4-cyanobenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852200", "l": "Inactivation of LCK by PTPN22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149519", "l": "MMACHC decyanates CNCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32337", "l": "(1S,4R)-fenchone + H(+) + NADPH => (1S,2S,4R)-endo-fenchol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227755", "l": "Recruitment of IKK complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5604929", "l": "Activated protein C binds Protein S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27313", "l": "naphthalene-1,2-diol + O2 <=> 2-hydroxychromene-2-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473596", "l": "Collagen type I degradation by MMP15 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52257", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797553", "l": "Protein 4.1 binds CASK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29409", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77692", "l": "a ganglioside GD1b (d18:1(4E)) + GDP-beta-L-fucose => a ganglioside Fuc-GD1b (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25113", "l": "H2O + pyridoxine 5'-phosphate => phosphate + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47979", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623051", "l": "Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48865", "l": "2-methylpropan-1-amine + FADH2 + O2 => FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716913", "l": "ESR1 binds ESR1 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62096", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23358", "l": "ADP + H(+) + O-phospho-L-seryl-[rhodopsin] => ATP + L-seryl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67547", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38689", "l": "(4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate => (4R)-hydroxysphinganine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785684", "l": "Fibronectin degradation by CTSG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383190", "l": "HCO3- transport through ion channel (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61624", "l": "2-oxoglutarate + cadaverine = 5-aminopentanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40592", "l": "decanedioyl-CoA + H2O => CoA + decanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010486", "l": "manganese:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033520", "l": "TYSND1 cleaves TYSND1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205649", "l": "p62 links damaged mitochondria to LC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634402", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660660", "l": "p300 acetylates RELA subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646468", "l": "mTORC1 binds RHEB:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674093", "l": "PDGFRs bind type I TKI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15378", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP => (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25274", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209536", "l": "IkB is ubiquitinated and degraded (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3878123", "l": "Initiation of SAHF formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76422", "l": "2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19973", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine", "d": [], "t": []}, {"i": "EC:2.5.1.22", "l": "\"spermine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66699", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24789", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981713", "l": "C4b binds to cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871373", "l": "BMX phosphorylates RUFY1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47342", "l": "6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35731", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA = 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75028", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate => 9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60308", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.357", "l": "\"[histone H3]-lysine(36) N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694522", "l": "Inner coat assembly and cargo binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46244", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33046", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 <=> (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928607", "l": "p-EPHs bind VAV2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372422", "l": "oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73776", "l": "dimethylallyl diphosphate + preechinulin => diphosphate + tardioxopiperazine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203611", "l": "N-myristoylation of eNOS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801776", "l": "REG3A binds bacterial phospholipids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15130", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102493", "l": "wogonin 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: wogonin + UDP-alpha-D-glucose = wogonin 7-O-beta-D-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65467", "l": "2-methylbutan-1-ol + butanoyl-CoA <=> 2-methylbutyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23270", "l": "glycine + urea => guanidinoacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10628", "l": "phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)", "d": [], "t": []}, {"i": "EC:2.7.7.56", "l": "\"tRNA nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55218", "l": "diphosphate + rhizathalene A => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782943", "l": "UV-DDB ubiquitinates XPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004586", "l": "ornithine decarboxylase activity", "d": ["Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106156", "l": "peptidyl-lysine 4-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2."], "t": []}, {"i": "RHEA:57156", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77542", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA <=> 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72325", "l": "3 Na(+)(in) + thiosulfate(in) => 3 Na(+)(out) + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626549", "l": "IQGAPs bind CALM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0071916", "l": "dipeptide transmembrane transporter activity", "d": ["Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641205", "l": "RSPO:LGR binds ZNRF3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004764", "l": "shikimate 3-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38220", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-500708", "l": "GRIK3 homomer binds glutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65703", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66857", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19352", "l": "(R)-4-dehydropantoate + H2O + NAD(+) <=> (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388817", "l": "ICOS binds ICOSL/B7-H2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106222", "l": "lncRNA binding", "d": ["Binding to a long noncoding RNA (lncRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67651", "l": "dATP + H2O <=> 2'-deoxyadenosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45436", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67150", "l": "2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein] => L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008054", "l": "IL1F10 binds IL1RAPL1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008960", "l": "phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700175", "l": "Active ALK phosphorylates SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70879", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) = L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30040", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 => benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671687", "l": "PRLR activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60011", "l": "a tRNA precursor + 2 CTP <=> a tRNA with a 3' CC end + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222128", "l": "NOC2L binds TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140610", "l": "RNA sequestering activity", "d": ["Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333678", "l": "CPNEs bind PL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017075", "l": "syntaxin-1 binding", "d": ["Binding to a syntaxin-1 SNAP receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51205", "l": "6-trans-leukotriene B4 + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71581", "l": "CDP(in) + CDP-L-ribitol(out) => CDP(out) + CDP-L-ribitol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41171", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O = 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817940", "l": "Expression of DUXA in the embryo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008709", "l": "cholate 7-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72148", "l": "AH2 + S-adenosyl-L-methionine + UTP => 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474266", "l": "Formation of collagen fibrils (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824402", "l": "ADAMTS13 variant does not cleave VWF multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656248", "l": "Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14658", "l": "aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139906", "l": "Activation of BAD by calcineurin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68731", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10248", "l": "dUTP + H2O = diphosphate + dUMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909732", "l": "Phosphorylation of STAT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76905", "l": "2-methylcyclohexanone + H(+) + NADH + NH4(+) => (1S)-2-methyl-cyclohexylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14671", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADPH => D-glyceraldehyde 3-phosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10898", "l": "2 H(+) + limonoate => 2 H2O + limonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.382", "l": "\"methoxylated aromatic compound--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26031", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102055", "l": "12-hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52019", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683679", "l": "Ubiquination of protein E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63972", "l": "A + dihydropyriculol = AH2 + pyriculol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.9", "l": "\"Xaa-Pro aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71227", "l": "2 Na(+)(out) + selenocyanate(out) = 2 Na(+)(in) + selenocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71750", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) <=> 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50072", "l": "ATP + H2O + tauroursodeoxycholate(in) = ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34397", "l": "L-beta-phenylalanine => L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417927", "l": "P2Y2 receptor binds ATP and UTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43638", "l": "2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008694", "l": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity", "d": ["Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30232", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine => (2E,6E)-farnesal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52761", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71688", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) => glycyl-L-aspartate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62417", "l": "(E)-4-coumaroyl-CoA + H2O => 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37269", "l": "L-alanine + L-aspartate => H2O + L-alanyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76460", "l": "(E)-sinapyl alcohol + A => (E)-sinapaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033883", "l": "pyridoxal phosphatase activity", "d": ["Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446694", "l": "IRAK4 phosphorylates IRAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031689", "l": "A3 adenosine receptor binding", "d": ["Binding to an A3 adenosine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12200", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + mugineate + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.24", "l": "\"2'-deoxymugineic-acid 2'-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43193", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018573", "l": "NOTCH3 binds activated EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48363", "l": "a 1,2-saturated fatty acid + H2O2 <=> a 2-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38939", "l": "dioscin + 2 H2O = diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:3.2.1.190", "l": "\"dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31213", "l": "diphosphate + L-adenosylselenomethionine + phosphate => ATP + H2O + L-selenomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18346", "l": "a cis-3-alkyl-4-alkyloxetan-2-one => a cis-alkene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40390", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848077", "l": "PTK6 phosphorylates STAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705584", "l": "HMGCR dimer binds statins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58257", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] => ADP-D-ribose + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177491", "l": "Formation of clathrin-coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70692", "l": "ornithine => putrescine + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74540", "l": "creatinine(in) => creatinine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58586", "l": "(-)-tabersonine + acetate + H(+) => dihydroprecondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836435", "l": "p-PKR dimer phosphorylates SNCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693347", "l": "HTR1A binds 5HT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28837", "l": "citrate(in) + succinate(out) => citrate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15286", "l": "AMP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928597", "l": "EPH:EFN dimers tetramerise (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32896", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3777129", "l": "HDAC3 containing complexes deacetylate histone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65126", "l": "benzyl acetate + CoA => benzoyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65261", "l": "verruculide C epoxide => 3-hydroxypentacecilide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58890", "l": "4-nitrobenzoate + A + 2 H2O => 4-aminobenzoate + AH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718379", "l": "GNRHR binds chemical antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14122", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102082", "l": "demethylrebeccamycin--D-glucose O-methyltransferase activity", "d": ["Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine = H+ + rebeccamycin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39171", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759920", "l": "GATA4 binds the BMP4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68523", "l": "(2E,6E)-farnesyl diphosphate <=> beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052774", "l": "glucosyl-N-acetylglucosamine glucosaminidase activity", "d": ["Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35846", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391934", "l": "DP2 receptor can bind PGD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11278", "l": "4 benzosemiquinone + 2 H2O => 4 hydroquinone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10475", "l": "(2R,3S)-2,3-dimethylmalate <=> propanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687088", "l": "PKA phosphorylates MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73386", "l": "thiamine diphosphate(in) + thiamine phosphate(out) <=> thiamine diphosphate(out) + thiamine phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32273", "l": "4-methyl-2-oxopentanoate + CO2 + NADH => (2R,3S)-3-isopropylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62370", "l": "Fe(2+)(in) + 2 hydrogencarbonate(in) => Fe(2+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60383", "l": "L-dehydroascorbate(out) <=> L-dehydroascorbate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11346", "l": "a CMP-N-acyl-beta-neuraminate + diphosphate => an N-acylneuraminate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050195", "l": "phosphoribokinase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167408", "l": "The high affinity receptor complex binds to G-protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66263", "l": "CoA + IC-asc-C7-AMP <=> AMP + H(+) + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786650", "l": "DDHD1,2 hydrolyse PA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72986", "l": "dimethylallyl diphosphate + harmol <=> 6-(3-dimethylallyl)harmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54309", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986937", "l": "MECP2 is phosphorylated at T308 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033421", "l": "CCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424484", "l": "Phosphorylation of BTK by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73468", "l": "beta-alanyl-dopamine + H2O => beta-alanine + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60873", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69692", "l": "a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine => a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27368", "l": "bromide + S-adenosyl-L-methionine <=> bromomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10802", "l": "5-phospho-alpha-D-ribose 1-diphosphate + xanthine => diphosphate + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043365", "l": "[formate-C-acetyltransferase]-activating enzyme activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44076", "l": "ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70152", "l": "6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53997", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59459", "l": "NADP(+) + tetradecan-1-ol <=> H(+) + NADPH + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63860", "l": "(9Z,12Z)-octadecadienoate + O2 = (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59624", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine = 4-aminobutanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36786", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70957", "l": "H(+)(out) + L-glutamate(out) => H(+)(in) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56436", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59651", "l": "D-xylotriono-1,5-lactone + H2O <=> D-xylotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65360", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38243", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol = 1-O-eicosanyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30894", "l": "O-acetyl-L-serine + thiosulfate <=> acetate + H(+) + S-sulfo-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30080", "l": "ATP + CoA + crotonobetaine => AMP + crotonobetainyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32294", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine <=> 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69808", "l": "benzoyl-AMP + CoA => AMP + benzoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70232", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) => (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76109", "l": "(11R)-hydroxymethyl carlactonoate + CO2 + succinate => (11R)-methyl carlactonoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468040", "l": "Cohesin binds PDS5 and WAPAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23457", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => A + crepenynate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39226", "l": "(3R)-hydroxyoctacosanoyl-CoA <=> (2E)-octacosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811427", "l": "COPI vesicle uncoating at the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18964", "l": "D-allose + L-lysyl-[protein] <=> H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928631", "l": "GIT1 binds bPIX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12667", "l": "an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+) => a 2-deoxystreptamine antibiotic + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612444", "l": "ERBB4s80 binds STMN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46792", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63568", "l": "beta-casomorphin-7 + H2O = beta-casomorphin-6 + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19601", "l": "H(+) + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.6", "l": "\"orcinol 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72185", "l": "mRNA polyadenylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64176", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan = (9Z)-octadecenoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59270", "l": "AH2 + formaldehyde + L-lysyl-[protein] => A + H2O + N(6)-methyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981892", "l": "Active G alpha (z) binds RGS proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76147", "l": "perivine + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + vobasine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11725", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite => 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57020", "l": "apulose + ATP = ADP + apulose 4-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.233", "l": "\"apulose kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198611", "l": "AKT phosphorylates IKKalpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141118", "l": "nitric oxide dioxygenase activity, heme protein as donor", "d": ["Catalysis of the reaction: Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36210", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043852", "l": "monomethylamine methyltransferase activity", "d": ["Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.098012012402094", "identifiers": [{"i": "GO:0008080", "l": "N-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24697", "l": "(E)-isoeugenol + acetate + NADP(+) <=> (E)-coniferyl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46954", "l": "2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.15", "l": "\"renin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55772", "l": "a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.52", "l": "\"jasmonoyl--L-amino acid ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186798", "l": "GAP binds to PDGF-beta receptors only (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32818", "l": "Hg(2+)(in) <=> Hg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72078", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine <=> ADP + H(+) + ophthalmate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9837337", "l": "DCAKD phosphorylates DP-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61660", "l": "(2E)-geraniol + ATP = (2E)-geranyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54864", "l": "H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18072", "l": "L-arginine <=> D-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717182", "l": "L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047159", "l": "1-alkenylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24311", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27415", "l": "CO2 + formaldehyde + morphine + succinate => 2-oxoglutarate + codeine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380574", "l": "Dopamine synaptic vesicle docking and priming (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28289", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60026", "l": "(R,R)-chrysanthemol + diphosphate => (R,R)-chrysanthemyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50579", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69273", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10517", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) => (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61982", "l": "NADP(+) + ubiquinol-10 => H(+) + NADPH + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19022", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39857", "l": "a triacyl-sn-glycerol + glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28464", "l": "pyridoxal(out) => pyridoxal(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653514", "l": "USP17L2 deubiquitinates RCE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209925", "l": "DIT and MIT combine to form triiodothyronine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25672", "l": "H(+) + loliose + UDP => sucrose + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017491", "l": "RHOJ GEFs activate RHOJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449855", "l": "IL10 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2214351", "l": "PLK1 phosphorylates GORASP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849102", "l": "SRMS phosphorylates PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41011", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) = (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866269", "l": "ARRB bind GPCRs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15396", "l": "(2S,6S)-2,6-diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49455", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O <=> 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14043", "l": "mandelonitrile + vicianose => (R)-vicianin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.174", "l": "\"rhamnogalacturonan rhamnohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25859", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11934", "l": "acetone + hydrogen cyanide => 2-hydroxy-2-methylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50001", "l": "butane + H(+) + NADH + O2 => butan-1-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66747", "l": "ATP + H2O + N-acetyl-L-aspartate(in) <=> ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22901", "l": "(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21215", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003910", "l": "DNA ligase (ATP) activity", "d": ["Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43309", "l": "1-hexadecanoyl-sn-glycerol + ATP => 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66537", "l": "A + cholest-4,6-dien-3-one + H2O => 25-hydroxycholest-4,6-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30087", "l": "(S)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65260", "l": "verruculide C epoxide = 3-hydroxypentacecilide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51052", "l": "5alpha-androstan-3,17-dione + A = 5alpha-androst-1-ene-3,17-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62897", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47375", "l": "a quinone + D-glucose <=> a quinol + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004623", "l": "phospholipase A2 activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696358", "l": "TREM,CD300 binds lipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67047", "l": "A + asnovolin H <=> AH2 + chermesin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676268", "l": "Formation of the MLL4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13442", "l": "H2O + L-cysteate => H(+) + NH4(+) + pyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40416", "l": "H2O + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70971", "l": "citrate <=> isocitrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34449", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH => dTDP-6-deoxy-beta-L-talose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690494", "l": "RHOB translocates to the endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72133", "l": "agmatine(in) => agmatine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70814", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797100", "l": "CCNK binds CDK13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004491", "l": "methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity", "d": ["Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61770", "l": "H(+) + rebaudioside D + UDP => rebaudioside A + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983424", "l": "Budding of COPII coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29860", "l": "5'-deoxyadenosine + H2O => 5-deoxy-D-ribose + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18949", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": [], "t": []}, {"i": "EC:1.14.14.106", "l": "\"taxane 13alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103067", "l": "4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62827", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71208", "l": "iodide(out) + 2 Na(+)(out) => iodide(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209924", "l": "Dopa is decarboxylated to dopamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047956", "l": "glycerol dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433711", "l": "Cis-homodimerization of nectins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769383", "l": "CBY1 binds beta-catenin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17186", "l": "IMP + NADP(+) + NH4(+) => GMP + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25979", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49626", "l": "ADP + D-erythritol 1-phosphate + H(+) => ATP + erythritol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42413", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) => ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130194", "l": "ABL phosphorylates WAVEs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61623", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose <=> [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65028", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] = (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}, {"i": "EC:1.17.9.2", "l": "\"(+)-pinoresinol hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30132", "l": "H2O + octanoyl-[ACP] => H(+) + holo-[ACP] + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0000721", "l": "(R,R)-butanediol dehydrogenase activity", "d": ["Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77427", "l": "benzaldehyde + hydrogen cyanide = (S)-mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249386", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649856", "l": "Oxidative damage to the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61056", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63130", "l": "docosanoate + ethanolamine => H2O + N-docosanoyl-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390329", "l": "Dephosphorylation of AKT by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54332", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654533", "l": "KRAS4B recycles to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75715", "l": "CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32261", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde => beta-D-fructose 1-phosphate + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68411", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) <=> 2-oxosuberate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0141053", "l": "histone H2A ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H2A substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31018", "l": "H(+) + indole-3-carboxylate <=> CO2 + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30042", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177501", "l": "Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59961", "l": "N(alpha)-acetyl-D-methionine => N(alpha)-acetyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22651", "l": "holo-[cytochrome c] <=> apo-[cytochrome c] + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17236", "l": "L-fucose <=> L-fuculose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140813", "l": "urate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042242", "l": "cobyrinic acid a,c-diamide synthase activity", "d": ["Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72731", "l": "UDP-alpha-D-glucose(in) + UMP(out) = UDP-alpha-D-glucose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53888", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139917", "l": "tBID activates BAX protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374665", "l": "DCC interaction with SIAH1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75806", "l": "butanoate(out) + Na(+)(out) <=> butanoate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63077", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.44", "l": "\"lipopolysaccharide 3-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004336", "l": "galactosylceramidase activity", "d": ["Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29766", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74264", "l": "n H(+)(out) + spermine(in) => n H(+)(in) + spermine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40406", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21748", "l": "(S)-lactaldehyde + NADP(+) = H(+) + methylglyoxal + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.283", "l": "\"methylglyoxal reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54550", "l": "D-xylulose 5-phosphate + phosphate => D-xylulose 1,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74764", "l": "rhamnetin + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730888", "l": "Phosphorylation of PLC-gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9660557", "l": "RAS:GTP binds RAL GDS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163798", "l": "Furin cleaves pro-protein Z to protein Z (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787737", "l": "CSF3R binds CSF3 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977136", "l": "Amyloid precursor proteins form ordered fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016497", "l": "substance K receptor activity", "d": ["Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65475", "l": "2-methylbutanoyl-CoA + ethanol <=> CoA + ethyl 2-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810376", "l": "ING2 binds PI5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662597", "l": "MT1H binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783670", "l": "CRLF1 binds CLCF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047558", "l": "3-cyanoalanine hydratase activity", "d": ["Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47852", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53799", "l": "deoxycholoyl-CoA + ursodeoxycholate <=> deoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57731", "l": "H(+) + trans-aconitate <=> CO2 + itaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24514", "l": "3-(pyrazol-1-yl)-L-alanine + H2O => L-serine + pyrazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21490", "l": "beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+) => dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67123", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63647", "l": "GDP-beta-L-fucose + L-seryl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031729", "l": "CCR4 chemokine receptor binding", "d": ["Binding to a CCR4 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694563", "l": "ABHD10 hydrolyses MPAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12622", "l": "H(+) + L-aspartate => CO2 + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20378", "l": "androsterone + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29850", "l": "(2E)-tetradecenoyl-CoA <=> (3Z)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374896", "l": "Uptake of Noradrenaline (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44915", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (3E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11847", "l": "acetyl-CoA + formate <=> CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689630", "l": "BAP1 binds BAP1-interacting complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71214", "l": "chlorate(out) + 2 Na(+)(out) <=> chlorate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70904", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.7", "l": "\"ferric-chelate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818937", "l": "MEN1 binds MLL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16543", "l": "(3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9-cis-violaxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41441", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 => (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77153", "l": "1D-myo-inositol 4,5-bisphosphate + phosphate => 1D-myo-inositol 1,4,5-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210881", "l": "Dimerization of Tie2/Ang1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28903", "l": "D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47071", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156682", "l": "PLK1 phosphorylates NUDC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113638", "l": "Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209111", "l": "Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29241", "l": "H(+)(out) + uracil(out) => H(+)(in) + uracil(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687103", "l": "FOXO3 regulates MIR34B,C expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59681", "l": "D-maltopentaose + O2 => D-maltopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39589", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53407", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24881", "l": "A + L-sorbopyranose <=> 1-dehydro-L-sorbose + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0062037", "l": "D-loop DNA binding", "d": ["Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34852", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) => 3-oxoadipyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944454", "l": "mTORC1 phosphorylates MAF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40324", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77642", "l": "3'-phosphoadenylyl sulfate + H2O <=> adenosine 5'-phosphosulfate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169921", "l": "Glycosylation and Folding of HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717205", "l": "GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202459", "l": "Phosphorylation of Bcl10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783880", "l": "PIPOX oxidises PPCA to P6C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.63", "l": "\"kynurenine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38819", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64232", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA = atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73344", "l": "beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] => AMP + beta-alanyl-[peptidyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40115", "l": "H2O + hexanoyl-CoA = CoA + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58370", "l": "(2E,6Z)-nona-2,6-dienal + H(+) + NADPH => (2E,6Z)-nona-2,6-dien-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29346", "l": "L-aspartate(in) + succinate(out) <=> L-aspartate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41557", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42886", "l": "(R)-3-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68509", "l": "(2E,6E)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004740", "l": "pyruvate dehydrogenase (acetyl-transferring) kinase activity", "d": ["Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004588", "l": "orotate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69005", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite => AMP + cremeomycin + diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50331", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25272", "l": "(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754974", "l": "ADK phosphorylates RBV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68548", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29606", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] <=> 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032942", "l": "inositol tetrakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26044", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-9-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435244", "l": "PECAM1 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45083", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25697", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22246", "l": "H(+) + kaempferol 3-O-beta-D-xyloside + UDP => kaempferol + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690449", "l": "S1PR1 bind S1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014449", "l": "RHOG binds effectors at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55133", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050531", "l": "mannosyl-3-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211983", "l": "CYP2J2 oxidises ARA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39575", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66321", "l": "2',3'-cGAMP(out) => 2',3'-cGAMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806629", "l": "Formation of tonofilament bundles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77081", "l": "Formation of the CE:GMP intermediate complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830461", "l": "PAX2 binds the EMX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3899291", "l": "SUMOylation of EP300 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54379", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + nezukol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48220", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110244", "l": "Excision of FapyG by OGG1 glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791172", "l": "Expression of WIPI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030790", "l": "chlorophenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605717", "l": "GM2A binds and mobilizes ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27573", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate <=> ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71740", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) => 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008681", "l": "2-octaprenyl-6-methoxyphenol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33999", "l": "zymosterol = 5alpha-cholesta-7,24-dien-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60781", "l": "2-oxoglutarate + gibberellin A15 + O2 => CO2 + gibberellin A24 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27383", "l": "(2R)-2-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29418", "l": "(S)-lactate(in) + H(+)(in) <=> (S)-lactate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18311", "l": "a carboxylate + a D-alpha-amino acid => an N-acyl-D-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13716", "l": "a ubiquinone + succinate <=> a ubiquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004966", "l": "galanin receptor activity", "d": ["Combining with galanin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10491", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP <=> (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965450", "l": "DAAM1 recruits PFN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54896", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA = (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59281", "l": "L-asparagine => D-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43965", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44906", "l": "alpha-D-glucose + phosphate => alpha-D-glucose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25229", "l": "L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45026", "l": "7-dehydrocholesterol + 2 H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55266", "l": "di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21043", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791235", "l": "GADD45A binds AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0005363", "l": "maltose transmembrane transporter activity", "d": ["Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch."], "t": []}, {"i": "RHEA:33171", "l": "D-maltose(in) = D-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62836", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006588", "l": "MECP2 binds the PTPN4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.152", "l": "\"hydroperoxy icosatetraenoate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-445079", "l": "Phosphorylation of L1 by ERK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24381", "l": "(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63368", "l": "ATP + H2O + spermine(out) = ADP + H(+) + phosphate + spermine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001786", "l": "phosphatidylserine binding", "d": ["Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741411", "l": "CYLD deubiquitinates NEMO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694331", "l": "nsp3-4 is glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602458", "l": "Activation of proMMP10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51230", "l": "17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193665", "l": "MYD88 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805061", "l": "CK2 binds FACT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106256", "l": "hydroperoxy icosatetraenoate dehydratase activity", "d": ["A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432295", "l": "GPVI binds Fyn and Lyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40866", "l": "FAD + H(+) + heptadecanoyl-CoA <=> FADH2 + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71478", "l": "H2O + neurotensin <=> L-isoleucyl-L-leucine + neurotensin(1-11)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57099", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26410", "l": "H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:4.2.1.126", "l": "\"N-acetylmuramic acid 6-phosphate etherase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362427", "l": "Hh-Np binds GPC5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190256", "l": "FGFR1c binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44226", "l": "16-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 16-hydroxyhexadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71187", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) = 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66772", "l": "ATP + H2O + uroporphyrin I(in) = ADP + H(+) + phosphate + uroporphyrin I(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16059", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1370505", "l": "PRLR is phosphorylated at Ser-349 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73680", "l": "3'-AMP(in) + ADP(out) + H(+)(out) => 3'-AMP(out) + ADP(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0043139", "l": "5'-3' DNA helicase activity", "d": ["Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070976", "l": "TIR domain binding", "d": ["Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002460", "l": "P4HB binds Collagen chains (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.333167463679153", "identifiers": [{"i": "GO:0016791", "l": "phosphatase activity", "d": ["Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56629", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O => chloride + 2 H(+) + maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68817", "l": "(2Z,6E)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30305", "l": "germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43719", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate <=> [glutamine synthetase]-L-tyrosine + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009936", "l": "RNASEL cleaves cellular ssRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654224", "l": "Activated FGFR3 binds PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71257", "l": "3 Na(+)(in) + phosphate(in) => 3 Na(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-209792", "l": "N-acetylation of serotonin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20108", "l": "ADP + beta-D-fructose 6-phosphate <=> AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28162", "l": "cytidine + GTP = CMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112436", "l": "Formation of Elongin complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031760", "l": "Edg-7 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-7 lysophosphatidic acid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172433", "l": "Collagen type XIX degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27859", "l": "2',3'-cyclophospho-GMP + H2O => 3'-GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54390", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68960", "l": "DNA polymerase epsilon binds at the origin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24768", "l": "7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939963", "l": "Activated AKT phosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37935", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54738", "l": "2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102462", "l": "quercetin 3-sophoroside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose = quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61424", "l": "cis-cis-nepetalactol + NAD(+) = cis-cis-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222237", "l": "SMYD2 methylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18586", "l": "D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033434", "l": "AUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193668", "l": "p75NTR and RHOA-GDI interact (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009044", "l": "xylan 1,4-beta-xylosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690152", "l": "USP5 cleaves polyubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30363", "l": "fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": [], "t": []}, {"i": "EC:3.1.1.87", "l": "\"fumonisin B1 esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855648", "l": "SALM3 binds LAR-RPTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77019", "l": "2-aminocyclohexanol + H2O + NAD(+) = 2-hydroxycyclohexan-1-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44141", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate => acetyl-CoA + CO2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55941", "l": "all-trans-3,4-didehydroretinol + NAD(+) => all-trans-3,4-didehydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31042", "l": "dodecanoyl-CoA + FAD + H(+) <=> (2E)-dodecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807565", "l": "GNLY is transferred to the phagosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72564", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) => butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375395", "l": "C5a receptor binds C5a anaphylatoxin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73214", "l": "H(+)(in) + sucrose(out) <=> H(+)(out) + sucrose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53676", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43217", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine => (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29755", "l": "(R)-lipoate(in) = (R)-lipoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23526", "l": "an alkyl cinnamate + beta-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003827", "l": "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170964", "l": "FRS2 binds to active TrkA receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75979", "l": "argipressin(out) = argipressin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68418", "l": "(2R,3S)-iso(homo)2citrate => cis-(homo)2aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047723", "l": "inosinate nucleosidase activity", "d": ["Catalysis of the reaction: H2O + IMP = D-ribose 5-phosphate + hypoxanthine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76623", "l": "(R)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50996", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.127", "l": "\"[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75856", "l": "Abortive Initiation Before Second Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68532", "l": "(2E,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0038085", "l": "vascular endothelial growth factor binding", "d": ["Binding to a vascular endothelial growth factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74465", "l": "4'-methoxyviridicatin + H(+) + methyl isocyanate => (-)-4'-methoxycyclopenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377644", "l": "Release of CSK from SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031723", "l": "CXCR4 chemokine receptor binding", "d": ["Binding to a CXCR4 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210290", "l": "Interaction of PECAM-1 and SHIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390595", "l": "Calcium Binds Troponin-C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707856", "l": "PGRMC2:Hemes dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41831", "l": "(3R)-hydroxyhexanoyl-[ACP] <=> (2E)-hexenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28989", "l": "H(+)(out) + N-acetylneuraminate(out) => H(+)(in) + N-acetylneuraminate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052893", "l": "N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39371", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71363", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65902", "l": "glycine + H2O + xanthurenate => 3-hydroxy-L-kynurenine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032089", "l": "NACHT domain binding", "d": ["Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg2+-binding site and five more specific motifs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785607", "l": "FANCM binds FAAP24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732692", "l": "Triazenes produce DNA damage in the form of O6-methylguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50258", "l": "25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55491", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102281", "l": "formylaminopyrimidine deformylase activity", "d": ["Catalysis of the reaction: formylaminopyrimidine + H2O = 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688786", "l": "ATXN3 binds RAD23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62621", "l": "[thioredoxin]-dithiol + a hydroperoxide => [thioredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38470", "l": "a 2-acylglycerol + an acyl-CoA <=> a 2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53251", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57564", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9761027", "l": "ZEB2 binds SP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16044", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate <=> [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74922", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] <=> a (2E)-enoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029456", "l": "RAC1 and CDC42 activate PAK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708457", "l": "HM13 cleaves HMOX1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809707", "l": "MTMR12 binds MTMR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24576", "l": "diphosphate + H2O = H(+) + 2 phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.1", "l": "\"inorganic diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75862", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956649", "l": "The complex of RUNX1 and YAP1 binds the ITCH gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650722", "l": "Translation of DDIT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68233", "l": "L-cysteine(in) + Na(+)(in) => L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35288", "l": "ATP + chloramphenicol(in) + H2O => ADP + chloramphenicol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41970", "l": "a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+) => a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388596", "l": "Melanocortin receptors bind melanocortins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49470", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016165", "l": "linoleate 13S-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090564", "l": "protein-phosphocysteine-glucose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433815", "l": "viral dsRNA : TRL3 recruits TICAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44804", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) = 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34665", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980128", "l": "NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51663", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 <=> an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164514", "l": "Integrase binds viral DNA ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18899", "l": "AH2 + L-thyroxine => 3,3',5'-triiodo-L-thyronine + A + H(+) + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983259", "l": "Kinesins move along microtubules consuming ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.358", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67290", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine => ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645598", "l": "RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39265", "l": "(13Z)-docosenoyl-CoA + NADP(+) => (2E,13Z)-docosadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56960", "l": "a ribonucleoside 5'-triphosphate + pyruvate = a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684033", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449829", "l": "IL11 binds IL11RA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65995", "l": "calciol + hnu <=> 5,6-trans-vitamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48120", "l": "a ganglioside GD3 + H2O = a ganglioside GM3 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950260", "l": "Expression of Proteasome activator complex subunit 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015636", "l": "short-chain fatty acid transmembrane transporter activity", "d": ["Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69209", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044020", "l": "histone H4R3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44092", "l": "ATP + CoA + nonadecanoate = AMP + diphosphate + nonadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028724", "l": "AMOT proteins bind YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13681", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.37", "l": "\"DNA (cytosine-5-)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18342", "l": "D-xylono-1,4-lactone + H2O => D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682377", "l": "LC3 de-lipidation by ATG4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848150", "l": "STAT3 binds SOCS3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70447", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015575", "l": "mannitol transmembrane transporter activity", "d": ["Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9846477", "l": "A4GALT transfers galactose to LacCer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29689", "l": "alpha-D-glucose 1-phosphate + alpha-maltohexaose => alpha-maltoheptaose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050211", "l": "procollagen galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.4", "l": "\"phospholipase A2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352914", "l": "glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64604", "l": "L-seryl-[protein] + UTP = diphosphate + uridylyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54072", "l": "(2E)-geranyl diphosphate = beta-thujene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.177", "l": "\"beta-thujene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419166", "l": "GEFs activate RhoA,B,C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160935", "l": "SMURF1 ubiquitinates RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004776", "l": "succinate-CoA ligase (GDP-forming) activity", "d": ["Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110210", "l": "TDG glycosylase mediated recognition and binding of an ethenocytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17179", "l": "CoA + O-octanoyl-(R)-carnitine => (R)-carnitine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51150", "l": "an aldehyde + 2 H(+) + 2 reduced [azurin] => a primary alcohol + 2 oxidized [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102919", "l": "5,6-dimethylbenzimidazole synthase activity", "d": ["Catalysis of the reaction: FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047728", "l": "carnitine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047362", "l": "thiosulfate-dithiol sulfurtransferase activity", "d": ["Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432148", "l": "Fgr may phosphorylate p38 MAPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625693", "l": "TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36628", "l": "2-hydroxytetracosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54010", "l": "(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35195", "l": "L-quinate(in) = L-quinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51965", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48208", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14468", "l": "H2O + L-histidinol phosphate <=> L-histidinol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11380", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.72", "l": "\"[2-(trimethylamino)ethyl]phosphonate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694294", "l": "E pentamer is transported to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11283", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033524", "l": "TYSND1 cleaves SCP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65132", "l": "2-oxoglutarate + O2 + preaustinoid A1 = CO2 + H2O + preaustinoid A2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23547", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58287", "l": "5,6-dihydrothymine + NADP(+) <=> H(+) + NADPH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11174", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-methionine => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63462", "l": "(2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+) => (2E,6E,10E)-geranylgeraniol + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67079", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68677", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102940", "l": "phloroglucinol O-methyltransferase activity", "d": ["Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55855", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62647", "l": "(5Z,8Z)-eicosadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418904", "l": "A1 and A3 receptors bind adenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627078", "l": "XIAP binds CASP9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68605", "l": "(2S)-3-sulfopropanediol => H(+) + hydroxyacetone + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56464", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32782", "l": "ATP + Co(2+)(out) + H2O <=> ADP + Co(2+)(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40035", "l": "ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.41", "l": "\"N-acetylaspartylglutamate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50158", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098695", "l": "inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14042", "l": "(R)-vicianin + H2O => mandelonitrile + vicianose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37727", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210805", "l": "Removal of miRNA passenger strand (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696457", "l": "BDH2 dehydrogenates 3HBA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483087", "l": "PI is exchanged with PC by PITPNB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63970", "l": "atromentin + 2 H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72303", "l": "L-glutamate(in) + L-thyroxine(out) = L-glutamate(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693604", "l": "XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33453", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] => A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004514", "l": "nicotinate-nucleotide diphosphorylase (carboxylating) activity", "d": ["Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27463", "l": "diphosphate + GDP-D-glycero-alpha-D-manno-heptose => D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57061", "l": "2''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836998", "l": "GRSF1 unwinds quadruplex G regions in RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38488", "l": "1-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25016", "l": "H(+) + N,N-dihydroxy-L-tryptophan <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2545253", "l": "Deacetylation of cohesin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13274", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol => 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63701", "l": "mycophenolate + UDP-alpha-D-glucuronate => mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034336", "l": "misfolded RNA binding", "d": ["Binding to an RNA molecule that has assumed an incorrect conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66733", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549322", "l": "OCT1 transports organic cations out of hepatic cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76500", "l": "N-acetyl-D-glutamate => N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68025", "l": "H2O + presqualene monophosphate => phosphate + presqualene alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654425", "l": "Activated FGFR4 binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64338", "l": "4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA => H(+) + 2 malonyl-CoA + nicotinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40553", "l": "H(+) + phylloquinol + S-adenosyl-L-homocysteine => demethylphylloquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005003", "l": "ephrin receptor activity", "d": ["Combining with an ephrin receptor ligand to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28111", "l": "chloride + S-adenosyl-L-methionine => 5'-chloro-5'-deoxyadenosine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990605", "l": "GU repeat RNA binding", "d": ["Binding to an RNA molecule containing GU repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983285", "l": "RAD51B binds RAD51C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16111", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432897", "l": "ILK interacts with beta-1 integrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58248", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68825", "l": "(2E)-geranyl diphosphate => (Z)-beta-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140608", "l": "cysteine-type endopeptidase activator activity", "d": ["Binds to and increases the activity of a cysteine-type endopeptidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36829", "l": "D-glucose + diosgenin + 2 L-rhamnopyranose => dioscin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20851", "l": "H(+) + O2 + phosphate + pyruvate <=> acetyl phosphate + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35543", "l": "3-phosphooxypyruvate + H2O = 3-hydroxypyruvate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047527", "l": "2,3-dihydroxybenzoate-serine ligase activity", "d": ["Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175177", "l": "Association of  XRCC4:DNA ligase IV complex with viral DNA ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75149", "l": "(-)-cyatha-3,12-diene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21372", "l": "H(+) + H2O + urethane = CO2 + ethanol + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.75", "l": "\"urethanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050006", "l": "isomaltulose synthase activity", "d": ["Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24326", "l": "1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+) => 6-oxocineole + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52171", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183126", "l": "Factor B binds to surface-associated C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38888", "l": "H2O + N-hexanoyl-sphinganine => hexanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53387", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33350", "l": "2-iminoacetate + H2O <=> glyoxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47609", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32908", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718360", "l": "GNRHR binds GNRHR peptide agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74036", "l": "D-serine(out) + L-alanine(in) => D-serine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29524", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50291", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21414", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72052", "l": "butanoate(out) + estrone 3-sulfate(in) => butanoate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66242", "l": "AMP + diphosphate + IC-asc-C9-CoA => ATP + CoA + IC-asc-C9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23281", "l": "acetyl-CoA + cysteamine => CoA + S-acetylcysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023859", "l": "Estrogen-responsive TFF1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46960", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.1.109", "l": "\"butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373705", "l": "Caspase cleavage of DCC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74716", "l": "Insulin binds the insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732527", "l": "FFAR1 binds rosiglitazone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296045", "l": "Activation of Potassium transport channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38885", "l": "a fatty acyl-CoA + AMP + diphosphate => a fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41240", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]-acylsphin-4-enine + O2 => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27810", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.92", "l": "\"(2Z,6Z)-farnesyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28317", "l": "baicalein + UDP-alpha-D-glucuronate <=> baicalin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24402", "l": "ADP + UDP => ATP + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021596", "l": "Membrane estrogen receptors bind SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10903", "l": "an aromatic L-alpha-amino acid + glyoxylate <=> an aromatic oxo-acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50420", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] = H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32437", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71279", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) = chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209109", "l": "Further phosphorylation of ARM by SGG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211219", "l": "Translocation of caspase-3 to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028598", "l": "Phosphorylation of YAP by LATS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018803", "l": "4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity", "d": ["Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28976", "l": "H(+)(out) + L-asparagine(in) => H(+)(in) + L-asparagine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15007", "l": "CO2 + gibberellin A8 + succinate => 2-oxoglutarate + gibberellin A1 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9772351", "l": "Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47107", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48300", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12902", "l": "D-arginine + H2O => D-ornithine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70636", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912359", "l": "HES1 binds TLE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63402", "l": "Fe(II)-heme a + H2O => Fe(II)-hydroxyheme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46945", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) => H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0047224", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28556", "l": "D-mannose + phosphate => D-mannose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12498", "l": "6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 4 H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21429", "l": "(2R)-3-sulfolactate => H(+) + pyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32766", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine <=> (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218847", "l": "PAK2 binds NCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938773", "l": "RNF144A polyubiquitinates PRKDC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12937", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.23", "l": "\"1-acylglycerophosphocholine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.-", "l": "\"Pentosyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704655", "l": "SARS-CoV-1 E binds BCL2L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38090", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19347", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55935", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O <=> AMP + H(+) + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69085", "l": "acrolein + H2O + NAD(+) => acrylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54986", "l": "a ubiquinone + 2 e(-) + 2 H(+) => a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2981040", "l": "COLEC12:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042767", "l": "ecdysteroid 22-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 22."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390649", "l": "CHRM1,3,5 bind acetylcholine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.335741739186091", "identifiers": [{"i": "GO:0004407", "l": "histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72919", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16712", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718020", "l": "PTGFR binds PTGFR agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53532", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56433", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140983", "l": "calcium:manganese antiporter activity", "d": ["Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in)."], "t": []}, {"i": "RHEA:73059", "l": "Ca(2+)(in) + Mn(2+)(out) = Ca(2+)(out) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10762", "l": "acetate + oxaloacetate => citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928591", "l": "EPH:EFN tetramers oligomerise (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.48", "l": "\"sucrose alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69851", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46770", "l": "a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371518", "l": "SIRT1 binds to HSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12605", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2", "d": [], "t": []}, {"i": "EC:2.2.1.7", "l": "\"1-deoxy-D-xylulose-5-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624952", "l": "Assembly of the retrograde IFT train (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13814", "l": "benzene + H(+) + NADH + O2 => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299475", "l": "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247840", "l": "WLS binds WNT ligands in the Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391372", "l": "GNRHR binds GNRH1,2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71850", "l": "glycoursodeoxycholate(out) <=> glycoursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13114", "l": "2-acetamidofluorene + H2O + NADP(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004309", "l": "exopolyphosphatase activity", "d": ["Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664940", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43526", "l": "aminoacetone + CO2 + NADPH => L-allo-threonine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56865", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12196", "l": "keto-D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": [], "t": []}, {"i": "EC:4.1.2.22", "l": "\"fructose-6-phosphate phosphoketolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682111", "l": "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0031545", "l": "peptidyl-proline 4-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47887", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160874", "l": "HYAL1 hydrolyses (HA)50 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002428", "l": "Removal of fibrillar collagen N-propeptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54450", "l": "a tRNA + an N-acyl-L-amino acid + H(+) => an N-acyl-L-alpha-aminoacyl-tRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25470", "l": "beta-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12681", "l": "creatinine + H(+) + H2O = N-methylhydantoin + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.21", "l": "\"creatinine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53396", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368081", "l": "Expression of SREBF1 (SREBP1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174367", "l": "GCL ligates L-Glu to L-Cys (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593685", "l": "Netrin-4 binds DCC/UNC5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36332", "l": "ATP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977375", "l": "CR1 binds C3bBb/C4bC2a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75172", "l": "Formation of RAD50:MRE11 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77700", "l": "a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1balpha  (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877345", "l": "IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45933", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41042", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392870", "l": "Gs activation by prostacyclin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371554", "l": "HSF1 acetylation at Lys80 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051018", "l": "protein kinase A binding", "d": ["Binding to a protein kinase A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12924", "l": "glycine + H(+) + succinyl-CoA <=> 5-aminolevulinate + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36644", "l": "emodin + S-adenosyl-L-methionine => H(+) + questin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12546", "l": "2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate => 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10221", "l": "ATP + L-tyrosine + tRNA(Tyr) => AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800298", "l": "HGF dimer binds MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55999", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63797", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75856", "l": "Abortive Initiation Before Second Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047900", "l": "formate kinase activity", "d": ["Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25872", "l": "H2O2 + pyridine = H2O + pyridine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30966", "l": "7,9,9'-tri-cis-neurosporene + a quinone <=> 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833363", "l": "HNF1B binds the WNT9B gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53700", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68150", "l": "(2R)-octan-2-ol + NADP(+) => 2-octanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28774", "l": "(2E)-hexadecenoyl-CoA <=> (9Z)-hexadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19020", "l": "(6S)-NADHX + ATP <=> ADP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67650", "l": "2'-deoxyadenosine + H(+) + triphosphate => dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67806", "l": "CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17126", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine => 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57525", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O => a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685319", "l": "CX3 complex formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42786", "l": "2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine => adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62695", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 <=> 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015513", "l": "high-affinity secondary active nitrite transmembrane transporter activity", "d": ["Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805640", "l": "AKT phosphorylates KAT6A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57650", "l": "equisetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trichosetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43058", "l": "10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+) => 5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850777", "l": "SPINK6 binds KLK14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940561", "l": "MMP7 cleaves OPTC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13278", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132759", "l": "TCN1 binds RCbl (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975100", "l": "Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45521", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71801", "l": "Ca(2+)(out) + H(+)(in) => Ca(2+)(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953398", "l": "PIR oxygenates quercetin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72189", "l": "H(+)(in) + sucrose(in) => H(+)(out) + sucrose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692755", "l": "CDK1 phosphorylates MAPK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61486", "l": "a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77141", "l": "1D-myo-inositol 2-phosphate + phosphate => 1D-myo-inositol 2,3-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332235", "l": "CBL binds TGFBR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62310", "l": "(+)-malbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983152", "l": "Transfer of ubiquitin from E1 to E2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20671", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50853", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627056", "l": "Procaspase 9 forms dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36964", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50553", "l": "prostaglandin C1 => prostaglandin B1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45832", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179410", "l": "Association of Nek2A with MCC:APC/C (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76210", "l": "3',5'-cyclic GMP(in) <=> 3',5'-cyclic GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65721", "l": "2-oxoglutarate + butyl sulfate + O2 => butanal + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46122", "l": "4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18457", "l": "D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": [], "t": []}, {"i": "EC:4.1.99.12", "l": "\"3,4-dihydroxy-2-butanone-4-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39314", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426489", "l": "RISC binds inexactly matching target RNAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210767", "l": "HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222325", "l": "Carboxymycobactin and mycobactin exchange their iron load (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33767", "l": "a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047918", "l": "GDP-mannose 3,5-epimerase activity", "d": ["Catalysis of the reaction: GDP-mannose = GDP-L-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517705", "l": "p-S318,221-HuR binds mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66068", "l": "4-methyl-2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848606", "l": "PTK6 phosphorylates PXN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46348", "l": "(2E)-octenoyl-CoA + H2O = 3-hydroxyoctanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31308", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707659", "l": "Hemes:LY96 activates TLR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607733", "l": "BCL10 binds CARD9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391941", "l": "BLT receptors can bind LTB4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24850", "l": "3,4-dihydroxybenzoate + H2O => 3-dehydroshikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851088", "l": "JUNB- and NPM1-ALK-mediated GZMB gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56043", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110319", "l": "Elongation by POLH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31588", "l": "FMNH2 + NADH + O2 + uracil => (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167408", "l": "The high affinity receptor complex binds to G-protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35557", "l": "4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid => cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62202", "l": "acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => ethanol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15830", "l": "a 16alpha-hydroxysteroid => a 16beta-hydroxysteroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009018", "l": "sucrose phosphorylase activity", "d": ["Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008767", "l": "UDP-galactopyranose mutase activity", "d": ["Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65335", "l": "H(+) + NADPH + O2 + verruculide A <=> chrodrimanin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61360", "l": "ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52919", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130349", "l": "Generation of CLIP from lip10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71265", "l": "chloride(in) + L-proline(in) + 2 Na(+)(in) => chloride(out) + L-proline(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.921857375477728", "identifiers": [{"i": "GO:0016661", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.7.-.-", "l": "\"Acting on other nitrogenous compounds as donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27302", "l": "7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29558", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70713", "l": "D-alanine(out) => D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111970", "l": "PKC phosphorylates GRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204863", "l": "Interaction of Tie2 with Ang2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089714", "l": "UDP-N-acetyl-D-mannosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378956", "l": "Luteinizing hormone is a heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36733", "l": "1-nitrocyclohexene + H(+) + NADPH => 1-nitrocyclohexan + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198714", "l": "ERK5 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28756", "l": "a ubiquinone + sn-glycerol 3-phosphate => a ubiquinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665406", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32794", "l": "L-ectoine(in) <=> L-ectoine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254291", "l": "ERBB4s80 binds STAT5A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70596", "l": "GOT2 dimer deaminates L-Asp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69142", "l": "Recruitment of Dna2 endonuclease (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20769", "l": "3-phosphonopyruvate + H(+) => CO2 + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68666", "l": "17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20244", "l": "nicotinate + S-adenosyl-L-methionine <=> N-methylnicotinate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.22", "l": "\"Bacillus subtilis ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685242", "l": "CHEK1 phosphorylates BRCA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55045", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O => (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27661", "l": "2-deoxy-alpha-D-ribose 1-phosphate <=> 2-deoxy-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41572", "l": "lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725342", "l": "NPM1-ALK-dependent JUNB gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691004", "l": "XPC binds RAD23 and CETN2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031510", "l": "Expression of APOC1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047906", "l": "fucosterol-epoxide lyase activity", "d": ["Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14858", "l": "(indol-3-yl)acetate + ATP + L-lysine => ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75330", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41722", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59047", "l": "dammarenediol-II + UDP-alpha-D-glucose <=> (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63014", "l": "diphosphate + ilicicolinate B => (2E,6E)-farnesyl diphosphate + orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38187", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75628", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O => ectocarpin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250947", "l": "B-WICH complex binds rDNA promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69870", "l": "a uridine in RNA + S-adenosyl-L-methionine <=> a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875374", "l": "MET binds LRIG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265456", "l": "NPC1L1 binds ezetimibe (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32174", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17796", "l": "H2O + L-alanyl-tRNA(Thr) <=> H(+) + L-alanine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.14", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59680", "l": "D-maltopentaose + O2 = D-maltopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41858", "l": "(3R)-hydroxydecanoyl-[ACP] + NADP(+) => 3-oxodecanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71568", "l": "5-phosphomethyl-dUMP in DNA + L-serine => 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13245", "l": "D-threo-isocitrate = glyoxylate + succinate", "d": [], "t": []}, {"i": "EC:4.1.3.1", "l": "\"isocitrate lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45182", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine => 2 (E)-4-coumaroyl-CoA + spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204871", "l": "Interaction of Tie2 and Grb2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39269", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+) => (15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9011543", "l": "DCA binds PDK2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51376", "l": "dopamine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202703", "l": "CD47 binds SIRP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20609", "l": "2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.28", "l": "\"2-dehydro-3-deoxy-D-pentonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17403", "l": "4-carboxy-2-hydroxy-cis,cis-muconate + H2O => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046987", "l": "N-acetyllactosamine beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38938", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28933", "l": "4-carboxy-2-hydroxy-cis,cis-muconate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64747", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine <=> 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50047", "l": "an acyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761421", "l": "CDH11 associates with catenins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67320", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210971", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65039", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48802", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46347", "l": "propanoyl-CoA + tetradecanoyl-CoA <=> 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174916", "l": "Formation of N-glucuronides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19876", "l": "dehydroepiandrosterone 3-sulfate + H2O <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31170", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) <=> 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677050", "l": "Formation of the GCN5-ATAC complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225978", "l": "Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730904", "l": "Auto-ubiquitination of TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372819", "l": "PCK2 phosphorylates OA to yield PEP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390120", "l": "Phosphorylated HPO dimer phosphorylates TH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36460", "l": "glycyl-L-proline + H2O => glycine + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52155", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878193", "l": "RUNX3 binds the JAG1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090632", "l": "N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15354", "l": "all-trans-violaxanthin + L-ascorbate => all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050506", "l": "vomilenine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + vomilenine = H+ + raucaffricine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050012", "l": "juglone 3-hydroxylase activity", "d": ["Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781941", "l": "WNTs are secreted in exosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805981", "l": "HMGB1 release from cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75816", "l": "ATP + H2O + K(+)(in) => ADP + H(+) + K(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69928", "l": "adenosine(out) + Na(+)(out) => adenosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66102", "l": "H2O + kynurenate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53970", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP] => apo-[BtrI ACP] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "60.539453696671714", "identifiers": [{"i": "GO:0016874", "l": "ligase activity", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient."], "t": []}, {"i": "EC:6.-.-.-", "l": "\"Ligases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629154", "l": "NEIL1 recognizes and binds thymine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54762", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043816", "l": "phosphoserine-tRNA(Cys) ligase activity", "d": ["Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23901", "l": "cis-stilbene oxide + H2O => (1R,2R)-hydrobenzoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52706", "l": "D-ribose 5-phosphate + uracil => H2O + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679031", "l": "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57327", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57759", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169398", "l": "ISGylation of host protein filamin B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43804", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19227", "l": "5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1901567", "l": "fatty acid derivative binding", "d": ["Binding to fatty acid derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61455", "l": "H(+) + NADPH + O2 + oxytetracycline <=> 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106155", "l": "peptidyl-lysine 3-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28055", "l": "2-oxobutanoate + CoA => formate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016802", "l": "trialkylsulfonium hydrolase activity", "d": ["Catalysis of the hydrolysis of a thioether bond, -S-."], "t": []}, {"i": "EC:3.3.1.-", "l": "\"Thioether and trialkylsulfonium hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62055", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.755473255981116", "identifiers": [{"i": "GO:0008408", "l": "3'-5' exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end."], "t": []}, {"i": "REACT:R-HSA-3245943", "l": "Viral DNA cleavage by TREX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668904", "l": "Formation of the CTF18 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.151", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22001", "l": "D-xylose + NADP(+) => D-xylono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57863", "l": "(E)-6-hydroxyferuloyl-CoA <=> CoA + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56106", "l": "4,4'-diaponeurosporenal + 2 A + 3 H2O => 2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62895", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112703", "l": "PTPN11 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59727", "l": "D-maltoheptaono-1,5-lactone + H2O <=> D-maltoheptaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40495", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 = N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16615", "l": "an N-acetylarylamine + CoA => acetyl-CoA + an arylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0140327", "l": "flippase activity", "d": ["Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54152", "l": "a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30179", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] = 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.10", "l": "\"oxalate oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13489", "l": "(S)-canadine + H(+) + 2 O2 = berberine + 2 H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.8", "l": "\"tetrahydroberberine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0055106", "l": "ubiquitin-protein transferase regulator activity", "d": ["Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141131", "l": "DNA N6-methyladenine demethylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + an N6-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42897", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39026", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40458", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64732", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199112", "l": "CRTAM binds to NECL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33848", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357479", "l": "p-AXL binds PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660666", "l": "CBP and p300 binds NF-kB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39164", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64613", "l": "ATP + L-glutamate + tRNA(Gln) => AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198756", "l": "ERK1/2 phosphorylates MSK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29105", "l": "4 H(+)(out) + menaquinol-8 + NAD(+) => 5 H(+)(in) + menaquinone-8 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018547", "l": "nitroglycerin reductase activity", "d": ["Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65142", "l": "A + berkeleyone A + H2O => AH2 + O2 + protoaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31587", "l": "FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0072532", "l": "tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804229", "l": "JMY, TTC5 and EP300 bind (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657649", "l": "ALKBH2 binds alkylated DNA containing 1-etA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35755", "l": "NAD(+) + UDP-alpha-D-glucose = H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791173", "l": "Expression of ATF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68525", "l": "(2Z,6Z)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50261", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione => (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043828", "l": "tRNA 2-selenouridine synthase activity", "d": ["Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787737", "l": "CSF3R binds CSF3 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420724", "l": "CASR binds Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31647", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": [], "t": []}, {"i": "EC:3.2.1.180", "l": "\"unsaturated chondroitin disaccharide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114354", "l": "SMAC binds XIAP:Caspase-7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73361", "l": "AMP + beta-alanyl-dopamine + diphosphate + H(+) => ATP + beta-alanine + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016761", "l": "cellulose synthase (GDP-forming) activity", "d": ["Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75493", "l": "25-hydroxyvitamin D3 sulfate(in) + n H(+)(in) => 25-hydroxyvitamin D3 sulfate(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18777", "l": "an alkylmercury + H(+) = an alkane + Hg(2+)", "d": [], "t": []}, {"i": "EC:4.99.1.2", "l": "\"alkylmercury lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619668", "l": "L-PRX:DRP:DGC:laminin-211 interacts with UTRN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24466", "l": "D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350440", "l": "FT binds to DS in an adjacent cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005133", "l": "type II interferon receptor binding", "d": ["Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58739", "l": "H2O + TTP <=> 5-methyl-UMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47218", "l": "6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942302", "l": "MMP13 cleaves OPTC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36707", "l": "O-ureido-L-serine = O-ureido-D-serine", "d": [], "t": []}, {"i": "EC:5.1.1.19", "l": "\"O-ureido-serine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51046", "l": "CO2 + NH4(+) + protodeoxyviolaceinate => indole-3-pyruvate imine dimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40489", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31278", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (S)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31879", "l": "(S)-2,3-epoxysqualene = beta-seco-amyrin", "d": [], "t": []}, {"i": "EC:5.4.99.54", "l": "\"beta-seco-amyrin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72017", "l": "2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A => acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0022810", "l": "membrane potential driven uniporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004435", "l": "phosphatidylinositol phospholipase C activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62319", "l": "salicylate + UDP-alpha-D-glucose <=> 1-O-salicyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35546", "l": "3-phosphooxypyruvate + H2O <=> 3-hydroxypyruvate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53784", "l": "beta-muricholate + deoxycholoyl-CoA = beta-muricholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43172", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.309", "l": "\"18S rRNA (guanine(1575)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15205", "l": "a dolichyl diphosphooligosaccharide + H2O = a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.44", "l": "\"oligosaccharide-diphosphodolichol diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16285", "l": "D-octopine + H2O + NAD(+) = H(+) + L-arginine + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.11", "l": "\"D-octopine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59782", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => L-histidine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46730", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2 => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483087", "l": "PI is exchanged with PC by PITPNB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708866", "l": "pro-F2R binds vorapaxar (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14431", "l": "a [oligopeptide](out) + ADP + H(+) + phosphate => a [oligopeptide](in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53109", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29588", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62447", "l": "L-canavanine + L-ornithine <=> H(+) + L-arginine + L-canaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48907", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964284", "l": "BTK in active Gq-BTK complex is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162590", "l": "Import of PIC to the Host Nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75230", "l": "H2O + L-xylono-1,4-lactone <=> H(+) + L-xylonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065966", "l": "SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34634", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31199", "l": "(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65568", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450325", "l": "c-FOS activation by phospho ERK1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60580", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837337", "l": "DCAKD phosphorylates DP-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66161", "l": "hexanoyl-CoA + tyramine => CoA + H(+) + N-hexanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019979", "l": "interleukin-4 binding", "d": ["Binding to interleukin-4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52686", "l": "H(+) + NADH + pyridoxal => NAD(+) + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23318", "l": "2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil => 2'-deoxyuridine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237119", "l": "Acireductone is oxidized to MOB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186780", "l": "PI3-kinase binds to the active receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399941", "l": "Rac1 binds PlexinA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33345", "l": "2-iminoacetate + H2O2 => glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197690", "l": "Detachment of WASP/WAVE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73475", "l": "D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381644", "l": "ER calcium channels open in response to activated PKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53019", "l": "chlorohydroquinone + 2 glutathione <=> chloride + glutathione disulfide + H(+) + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561072", "l": "OCT3 mediates renal uptake of organic cations (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33605", "l": "H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+) => H(+) + N-hexacosanoylsphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018334", "l": "Estrogen-responsive CXXC5 gene expresion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333671", "l": "CLCAs self cleave (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53049", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate => 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0042296", "l": "ISG15 transferase activity", "d": ["Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages."], "t": []}, {"i": "REACT:R-HSA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44348", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide B + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917693", "l": "ESCRT Disassembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38775", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15137", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-L-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58798", "l": "a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 7-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211193", "l": "Homodimerization  of DFF40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75524", "l": "acetyl-CoA + S-methyl-L-cysteine => CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5603467", "l": "Activated protein C is released from PROCR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211951", "l": "CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32881", "l": "(1R,4R)-bornane-2,5-dione + H(+) + NADH => (1R,4R,5R)-5-hydroxycamphor + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203977", "l": "SAR1 Activation And Membrane Binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610879", "l": "GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62599", "l": "(S)-8-oxocitronellyl enol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35335", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA = 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140948", "l": "histone H3K9 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41407", "l": "(R)-2-methylpyrrolidine + NADP(+) <=> 2-methyl-1-pyrroline + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625426", "l": "Retrograde IFT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39396", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65281", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001614", "l": "purinergic nucleotide receptor activity", "d": ["Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63919", "l": "5-fluorouridine + ATP <=> 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16189", "l": "3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate", "d": [], "t": []}, {"i": "EC:1.13.11.27", "l": "\"4-hydroxyphenylpyruvate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112396", "l": "Separation of elongating transcript from template (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197958", "l": "FPGS-2 transforms THF to THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28496", "l": "a menaquinol + dimethyl sulfoxide => a menaquinone + dimethyl sulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47630", "l": "3-methylmalate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54162", "l": "[ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28435", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] => ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797553", "l": "Protein 4.1 binds CASK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008987", "l": "quinolinate synthetase A activity", "d": ["Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72691", "l": "Formation of the 43S pre-initiation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809680", "l": "MTMR12 binds MTM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665761", "l": "FMNL3 binds RHOC:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033486", "l": "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411402", "l": "Activation of NLK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1369028", "l": "ABCAs mediate lipid efflux (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53538", "l": "(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646468", "l": "mTORC1 binds RHEB:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74602", "l": "AMP(out) + UDP-alpha-D-galactose(in) <=> AMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65538", "l": "H(+) + S-adenosyl-L-homocysteine + theacrine => 1,3,7-trimethylurate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65159", "l": "2-oxoglutarate + O2 + preaustinoid A2 <=> CO2 + H2O + preaustinoid A3 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59421", "l": "H2O + methylamine + O2 => formaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140233", "l": "intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592316", "l": "Initial activation of proMMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46240", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31068", "l": "6-amino-2-oxohexanoate => Delta(1)-piperideine-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013021", "l": "GDIs block activation of RHOB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60976", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33116", "l": "malonate(in) => malonate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58551", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102213", "l": "in-chain hydroxy fatty acyl-CoA synthetase activity", "d": ["Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66917", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65751", "l": "2-oxoglutarate + dodecyl sulfate + O2 <=> CO2 + dodecanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612219", "l": "ERBB4s80 binds to SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25348", "l": "D-tyrosyl-tRNA(Tyr) + H2O => D-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23224", "l": "trans-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.203", "l": "\"trans-zeatin O-beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651828", "l": "PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783530", "l": "gp130:JAKs bind CNTFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76484", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine => 2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56116", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.79", "l": "\"granzyme B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357472", "l": "PAK1-3 autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47666", "l": "2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42193", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39410", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33689", "l": "CoA + H(+) + taxol => 3'-N-debenzoyltaxol + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19471", "l": "H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44193", "l": "2-methylhexadecanoate + ATP + CoA => 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39281", "l": "ADP + dodecanoate(in) + H(+) + phosphate => ATP + dodecanoate(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51778", "l": "deoxycohumulone + diphosphate => 4-prenylphlorisobutanophenone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11008", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.72", "l": "\"IgA-specific serine endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37012", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9680443", "l": "ROCK1,2 bind ROCKi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983153", "l": "E1 mediated ubiquitin activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65548", "l": "a ganglioside Fuc-GM1 + H2O = alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607736", "l": "MALT1 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55751", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614614", "l": "Cysteine is degraded to serine and H2S (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19620", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443418", "l": "GP1b signaling involves c-Src (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003906", "l": "DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043751", "l": "polyphosphate:AMP phosphotransferase activity", "d": ["Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102913", "l": "3-aminomethylindole N-methyltransferase activity", "d": ["Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39421", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58842", "l": "(24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451511", "l": "TLR15 binds to recognized ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047165", "l": "flavonol-3-O-beta-glucoside O-malonyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61526", "l": "(15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202604", "l": "Formation of a heteromeric BMP receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60397", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005046", "l": "KDEL sequence binding", "d": ["Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202328", "l": "Translocation of PKC theta to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418904", "l": "A1 and A3 receptors bind adenosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58173", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => beta-pinacene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.295", "l": "\"momilactone-A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49333", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032781", "l": "WWTR1 (TAZ) binds TEAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70664", "l": "4-hydroxy-L-proline(in) + H(+)(in) => 4-hydroxy-L-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA => 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49217", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034886", "l": "gamma-aminovinylacetate deaminase activity", "d": ["Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177926", "l": "Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.4", "l": "\"uracil/thymine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22064", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.62", "l": "\"5alpha-hydroxysteroid dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3266557", "l": "Factor I cleaves iC3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10766", "l": "(4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26057", "l": "diphosphate + GDP-valienol => GTP + H(+) + valienol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34103", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}, {"i": "EC:5.1.3.26", "l": "\"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879459", "l": "F-actin capping protein is a heterodimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55992", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873921", "l": "Binding of STAT1 to p-IFNGR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21987", "l": "3'-phosphoadenylyl sulfate + choline <=> adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373732", "l": "Nephrin trans-homophilic interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41446", "l": "glycine + 2 H(+) + phosphate => (1R)-(2-amino-1-hydroxyethyl)phosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49728", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NADP(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30131", "l": "H2O + octanoyl-[ACP] = H(+) + holo-[ACP] + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0052905", "l": "tRNA (guanosine(9)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: guanosine9 in tRNA + S-adenosyl-L-methionine = H+ + N1-methylguanosine9 in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389980", "l": "unfolded actin/tubulin associates with prefoldin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009282", "l": "CDK1 phosphorylates RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53852", "l": "glycocholate + NAD(+) = 7-oxo-glycodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852317", "l": "PLK1 phosphorylates GTSE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27297", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10315", "l": "H(+) + NADH + O2 + terephthalate <=> (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201521", "l": "ALK autophosphorylation  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.161", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173542", "l": "SMURF2 ubiquitinates SMAD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12282", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39549", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9005980", "l": "IL21 binds IL21R:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75318", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) <=> chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40178", "l": "O2 + octanoyl-CoA <=> (2E)-octenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39992", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57561", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833723", "l": "PKR forms a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004612", "l": "phosphoenolpyruvate carboxykinase (ATP) activity", "d": ["Catalysis of the reaction: ATP + oxaloacetate = ADP + CO2 + H+ + phosphoenolpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74387", "l": "formamide(out) = formamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0045289", "l": "luciferin monooxygenase activity", "d": ["Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44576", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) = 2-all-trans-nonaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71816", "l": "3,3',5'-triiodo-L-thyronine(out) => 3,3',5'-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097100", "l": "supercoiled DNA binding", "d": ["Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995330", "l": "COX10 transforms heme to heme O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53666", "l": "H(+) + 2 H2O + pyridinestrone carboxylate => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43336", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) = CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": [], "t": []}, {"i": "EC:7.2.4.1", "l": "\"carboxybiotin decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72672", "l": "The 60S subunit joins the translation initiation complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29626", "l": "alpha-maltopentaose + beta-maltose <=> alpha-maltohexaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0015146", "l": "pentose transmembrane transporter activity", "d": ["Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198714", "l": "ERK5 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018616", "l": "trihydroxytoluene dioxygenase activity", "d": ["Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010291", "l": "carotene beta-ring hydroxylase activity", "d": ["Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791319", "l": "NID1 degradation by MMP19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0051020", "l": "GTPase binding", "d": ["Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193997", "l": "CYP11B1 oxidises 11DCORT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59733", "l": "biotinyl-5'-AMP + L-lysyl-[protein] => AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59464", "l": "NADP(+) + octadecan-1-ol = H(+) + NADPH + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571327", "l": "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54874", "l": "(4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-menthone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43543", "l": "ATP + L-seryl-[isocitrate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49568", "l": "2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": [], "t": []}, {"i": "EC:4.4.1.34", "l": "\"isoprene-epoxide--glutathione S-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11828", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.58", "l": "\"RNA 2',3'-cyclic 3'-phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77018", "l": "(S)-leucinol + H2O + NAD(+) <=> 1-hydroxy-4-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24588", "l": "ATP + D-arabinose = ADP + D-arabinose 5-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.54", "l": "\"D-arabinokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21212", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59410", "l": "acetate + L-aspartate => H2O + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944218", "l": "Association of procollagen type VIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32490", "l": "CDP-choline + H2O <=> CMP + 2 H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28092", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0017077", "l": "oxidative phosphorylation uncoupler activity", "d": ["Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617326", "l": "CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696357", "l": "LAIR2 binds collagen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2169046", "l": "Degradation of TGF-beta receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40282", "l": "(R)-carnitine + dodecanoyl-CoA <=> CoA + O-dodecanoyl-R-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417896", "l": "P2Y6 receptor can bind to UDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29471", "l": "D-ribose 5-phosphate + H2O = D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72513", "l": "(R)-carnitine(in) + 2-oxoglutarate(out) => (R)-carnitine(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111970", "l": "PKC phosphorylates GRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046562", "l": "glucose oxidase activity", "d": ["Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612672", "l": "ERBB4s80:ESR1 binds ERBB4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045544", "l": "gibberellin 20-oxidase activity", "d": ["Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70167", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61243", "l": "H2O + L-phenylalanine + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65873", "l": "1,17beta-dihydroxyandrostan-3-one + A => 17beta-hydroxyandrostan-1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71263", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) = chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61655", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26347", "l": "aldehydo-D-galacturonate + H(+) + NADPH => L-galactonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76409", "l": "an L-alpha-amino acid + L-proline => H2O + Xaa-L-Pro dipeptide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74607", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) = UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74848", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP => 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76246", "l": "a glycyl-glycyl-[protein] + H2O <=> [protein]-C-terminal glycine + N-terminal glycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444691", "l": "Prokineticin receptors bind prokineticin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44929", "l": "2-oxoheptanedioate + acetyl-CoA + H2O => (R)-trihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33317", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663511", "l": "BIL binds GSTA1, FABP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73639", "l": "CTP(out) + ITP(in) = CTP(in) + ITP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.343", "l": "\"phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30949", "l": "10-epi-gamma-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684140", "l": "ATM phosphorylates RBBP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72899", "l": "4-O-demethylbarbatate + S-adenosyl-L-methionine = proatranorin I + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35746", "l": "H(+) + NADPH + O2 + versicolorin B <=> 2 H2O + NADP(+) + versicolorin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0016639", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP."], "t": []}, {"i": "EC:1.4.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807008", "l": "PTPRJ dephosphorylates MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983152", "l": "Transfer of ubiquitin from E1 to E2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63204", "l": "H2O + octadecanoyl-[ACP] = H(+) + holo-[ACP] + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52385", "l": "L-glutamate + O-phospho-L-serine => H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63539", "l": "bradykinin(1-8) + H2O <=> bradykinin(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63935", "l": "abscisate(in) + ATP + H2O <=> abscisate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797271", "l": "Expression of MAOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63850", "l": "2 3',4'-dihydroxyaurone + 2 H2O => 2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002401", "l": "Association of procollagen type XVIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031796", "l": "type 1 metabotropic GABA receptor binding", "d": ["Binding to a type 1 metabotropic GABA receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634861", "l": "NPAS4 binds ARNT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950782", "l": "p-STAT1 binds p-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64749", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38791", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67972", "l": "ATP + ecdysone = ADP + ecdysone 22-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047499", "l": "calcium-independent phospholipase A2 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+."], "t": []}, {"i": "REACT:R-HSA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052861", "l": "glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group", "d": ["Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622572", "l": "NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32003", "l": "(+)-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689111", "l": "PARK2 autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67692", "l": "ATP + H2O + hexadecanedioate(in) = ADP + H(+) + hexadecanedioate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003681", "l": "bent DNA binding", "d": ["Binding to DNA in a bent conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59902", "l": "CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate => 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004974", "l": "leukotriene receptor activity", "d": ["Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28334", "l": "dATP + H2O = dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41850", "l": "NADP(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49537", "l": "2-amino-2-deoxy-D-gluconate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102773", "l": "dihydroceramide kinase activity", "d": ["Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55895", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 <=> a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55186", "l": "2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylundecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32324", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20387", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+) => (2R,3R)-dihydroquercetin + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446322", "l": "PARVA associates with Paxillin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50494", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5220959", "l": "TDG excises 5-formylcytosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607740", "l": "PKC-delta phosphorylates CARD9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43199", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114552", "l": "Thrombin-activated PARs activate G12/13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047112", "l": "pyruvate oxidase activity", "d": ["Catalysis of the reaction: H+ + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43215", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.-", "l": "\"Carbon-sulfur lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69386", "l": "(3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047376", "l": "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity", "d": ["Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10366", "l": "(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+) => 2-oxoglutarate + dodecanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49349", "l": "2,2-dihydroxyspirilloxanthin => 2-oxospirilloxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681375", "l": "KIT binds ripretinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46594", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43130", "l": "H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => guanosine(10) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0038187", "l": "pattern recognition receptor activity", "d": ["Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62673", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179417", "l": "Multiubiquitination of Nek2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51822", "l": "AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in) => ATP(in) + CoA(in) + decanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20114", "l": "beta-D-glucose 1-phosphate => beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873929", "l": "Casein kinase II phosphorylates STARD10 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54110", "l": "diphosphate + guaia-4,6-diene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5159250", "l": "ATF7IP binds SETDB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14543", "l": "cholate + CoA + H(+) => choloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45602", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-galactaro-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60459", "l": "ATP + UTP <=> 3',3'-cUAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004648", "l": "O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58957", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46904", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) = a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67679", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432533", "l": "PP1 binds to phosphorylated TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624494", "l": "RAF1 binds p21 RAS:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23784", "l": "a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62453", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate => AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592297", "l": "Full activation of MMP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44747", "l": "4 H(+) + 4 malonyl-CoA <=> (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15947", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose 6-phosphate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13633", "l": "ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.11", "l": "\"glutamate--putrescine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036174", "l": "butane monooxygenase activity", "d": ["Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418845", "l": "Activation of caspase-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67129", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57927", "l": "H2O + mutildienyl diphosphate <=> diphosphate + premutilin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73654", "l": "CTP(out) <=> CTP(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30105", "l": "5-dehydro-D-gluconate + NAD(+) => 2,5-didehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25468", "l": "(2E,6E)-farnesyl diphosphate = beta-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54031", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694492", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114683", "l": "Phosphorylation of Platelet Sec-1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848758", "l": "PTK6 phosphorylates AKT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66256", "l": "ATP + H(+) + IC-asc-C7 = diphosphate + IC-asc-C7-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59032", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39144", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679775", "l": "COMT binds COMT Inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69310", "l": "phenylacetonitrile + sulfate + sulfur => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193656", "l": "p75NTR interacts with RIP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008697", "l": "4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity", "d": ["Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022065", "l": "DSPGs are secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835151", "l": "Packaging of RdRP complex with replicated hRSV A nucleocapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0034040", "l": "ATPase-coupled lipid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45507", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22089", "l": "ATP + GTP => AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938382", "l": "LGALS3 gene expression is stimulated by RUNX1 and RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18324", "l": "2-oxoglutarate + L-leucine <=> 4-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371591", "l": "Trimerization of cytosolic HSF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045340", "l": "mercury ion binding", "d": ["Binding to a mercury ion (Hg)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41651", "l": "aniline + ATP + L-glutamate <=> ADP + N(5)-phenyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41613", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => D-ribose 2,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517674", "l": "p-S158,221-HuR binds mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75548", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH => (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58052", "l": "(2-aminoethyl)phosphonate + acetyl-CoA = (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66223", "l": "asc-omegaC7-CoA + O2 <=> asc-omegaDeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018826", "l": "RHOT2 hydrolyzes GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354087", "l": "Recruitment of GRB2 to p-PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13907", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52269", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine => (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264615", "l": "Loading of acetylcholine in synaptic vesicles (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667965", "l": "ANKLE2 binds PP2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47752", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine = 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016864", "l": "intramolecular oxidoreductase activity, transposing S-S bonds", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears."], "t": []}, {"i": "EC:5.3.4.-", "l": "\"Transposing S-S bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015608", "l": "carbohydrate-importing ABC transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)."], "t": []}, {"i": "TCDB:3.A.1.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450488", "l": "BRF1 Complex recruits RNA degradation activities (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46150", "l": "a 2'-deoxyribonucleoside + H(+) + triphosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686578", "l": "Activated ATM phosphorylates ABL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034739", "l": "histone H4K16 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63724", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806831", "l": "CYB5Rs reduce MetHb to HbA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69599", "l": "AMP + inosine <=> adenosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204169", "l": "PDP dephosphorylates p-lipo-PDH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428918", "l": "Dissociation of the TP:G13 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61477", "l": "a sphingoid base + octadecanoyl-CoA => an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21761", "l": "(3S)-3-hydroxybutanoyl-CoA => (3R)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33615", "l": "ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264615", "l": "Loading of acetylcholine in synaptic vesicles (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31747", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.91", "l": "\"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26328", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70433", "l": "2 H(+)(in) + Li(+)(out) => 2 H(+)(out) + Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68391", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 <=> 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33623", "l": "ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782637", "l": "HDAC8 deacetylates histones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179417", "l": "Multiubiquitination of Nek2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25971", "l": "(S)-benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34224", "l": "6-hydroxypseudooxynicotine + A + H2O => 2,6-dihydroxypseudooxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74600", "l": "AMP(out) + UDP-alpha-D-galactose(in) => AMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13266", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.18", "l": "\"lycopene epsilon-cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56879", "l": "(R)-N-acetyl-1-phenylethylamine + H2O <=> (R)-1-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54548", "l": "D-xylulose 1,5-bisphosphate + H2O = D-xylulose 5-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50421", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] => H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35330", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxodocosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38111", "l": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50683", "l": "H2O + N-terminal L-glutaminyl-[protein] <=> N-terminal L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202947", "l": "Caspase mediated cleavage of APC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71059", "l": "L-arginine(in) + L-leucine(out) = L-arginine(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21247", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688838", "l": "RIPK3 binds STUB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72582", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22240", "l": "H2O + methylenediurea = N-(carboxyaminomethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30904", "l": "demethylspheroidene + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10937", "l": "6-decylubiquinone + 2 thiosulfate => 6-decylubiquinol + tetrathionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34952", "l": "3-hydroxypropanoate(out) => 3-hydroxypropanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64804", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine = CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15071", "l": "chlorophyllide a + H2O => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56644", "l": "a uridine in mRNA = a pseudouridine in mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044686", "l": "cysteate synthase activity", "d": ["Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034617", "l": "tetrahydrobiopterin binding", "d": ["Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23909", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine => 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.272", "l": "\"D-2-hydroxyacid dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36999", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.-", "l": "\"Sulfotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51700", "l": "S-adenosyl-L-methionine + xanthogalenol = 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090524", "l": "cytochrome-b5 reductase activity, acting on NADH", "d": ["Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382058", "l": "Nck binds to the active PDGF receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin => O2 + reduced [NADPH--hemoprotein reductase] + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60881", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72751", "l": "H2O + ochratoxin A = L-phenylalanine + ochratoxin alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627350", "l": "SMAC (DIABLO) binds XIAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222738", "l": "Carboxymycobactin gets secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40364", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38997", "l": "a 1-acyl-sn-glycero-3-phosphate + choline + H(+) => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604360", "l": "Initial activation of proMMP2 by MMP14 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20409", "l": "alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN", "d": [], "t": []}, {"i": "EC:2.7.1.42", "l": "\"riboflavin phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33747", "l": "a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17996", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine <=> ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937820", "l": "SRC,YES1 bind YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30520", "l": "GTP + H(+) + phosphoenolpyruvate => diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0016727", "l": "oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule."], "t": []}, {"i": "EC:1.17.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71409", "l": "2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59176", "l": "ADP + L-serine = AMP + H(+) + O-phospho-L-serine", "d": [], "t": []}, {"i": "EC:2.7.1.226", "l": "\"L-serine kinase (ADP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161735", "l": "PGC2 is isomerised to PGB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42445", "l": "L-aspartate + NADP(+) => H(+) + iminosuccinate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44343", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate <=> AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47986", "l": "diphosphate + hydroxysqualene => H2O + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627072", "l": "RHOQ binds GOPC:CFTR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0004564", "l": "beta-fructofuranosidase activity", "d": ["Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45274", "l": "12-hydroxy-(9Z)-octadecenoate + phosphate => 12-phosphooxy-(9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62426", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => (E)-caffeoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395364", "l": "LTBP4 binds TGF-Beta-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26335", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70813", "l": "D-xylulose 5-phosphate + sulfoacetaldehyde => 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865276", "l": "PDGF-AB clevage by Furin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641229", "l": "TLE oligomerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980122", "l": "DTX binds NOTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51488", "l": "archaetidylserine + H(+) = archaetidylethanolamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696146", "l": "AOC2 deaminates TYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22276", "l": "2-oxoaldehyde + H2O + NAD(+) = a 2-oxocarboxylate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.23", "l": "\"2-oxoaldehyde dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55589", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45145", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O => acetaldehyde + CO2 + CoA + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.71", "l": "\"alcohol dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046429", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity", "d": ["Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63971", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> atromentin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45287", "l": "eicosanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471641", "l": "Defective OPN1MW causes COD5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731141", "l": "Syndecan-1 binds fibronectin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202212", "l": "Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005104", "l": "fibroblast growth factor receptor binding", "d": ["Binding to a fibroblast growth factor receptor (FGFR)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62175", "l": "an N-acylethanolamine phosphate + H2O <=> an N-acylethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790454", "l": "SUMOylation of XPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32498", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391211", "l": "Trace amine-associated receptors can bind trace amines (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13758", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-desulfoglucotropeolin + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.75", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28164", "l": "CMP + GDP + H(+) => cytidine + GTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0160009", "l": "histone decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67860", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112054", "l": "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976742", "l": "NOTCH2 coactivator complex binds FCER2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617829", "l": "Assembly of IFT A complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36980", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0001883", "l": "purine nucleoside binding", "d": ["Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211466", "l": "HNF1A-dependent synthesis of HNF4A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801109", "l": "CHM binds RGGT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70562", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.32", "l": "\"glucomannan 4-beta-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69965", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51549", "l": "(S)-tetrahydropapaverine + S-adenosyl-L-methionine => (S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74527", "l": "H(+) + N(6),N(6)-dimethyl-L-lysine = CO2 + N,N-dimethyl-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71868", "l": "glycodeoxycholate(out) => glycodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28079", "l": "2-hydroxyethylphosphonate + NAD(+) => H(+) + NADH + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33985", "l": "diphosphate + miltiradiene => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169398", "l": "ISGylation of host protein filamin B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813749", "l": "ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52837", "l": "H(+) + indole + NADH + O2 => H2O + indoxyl + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806974", "l": "MET dimers autophosphorylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13902", "l": "H2O + N-(aminomethyl)urea => N-(hydroxymethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70218", "l": "cortisol + H(+) + NADPH <=> 20beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63017", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19402", "l": "methanol + NAD(+) => formaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63869", "l": "(9Z)-octadecenoate + O2 => (2R,9Z)-2-hydroperoxyoctadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31218", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) <=> (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004808", "l": "tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity", "d": ["Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45538", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine => H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20043", "l": "2 H(+) + malonate + NADPH => 3-oxopropanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.239379048539433", "identifiers": [{"i": "GO:0016818", "l": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride which contains phosphorus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022841", "l": "potassium ion leak channel activity", "d": ["Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.13", "l": "\"protein kinase C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638104", "l": "UGCG transfers glucose to ceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67782", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052748", "l": "baicalin beta-D-glucuronidase activity", "d": ["Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043887", "l": "melibiose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1990599", "l": "3' overhang single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41128", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28187", "l": "aminoacetone + H2O + O2 => H2O2 + methylglyoxal + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112510", "l": "IL6ST is tyrosine phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76464", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A => 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685318", "l": "BCDX2 complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11095", "l": "NAD(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14031", "l": "AH2 + selenate => A + H2O + selenite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5227009", "l": "ABCF1 binds EIF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55505", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] => (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660829", "l": "ADORA2B binds Ade-Rib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176175", "l": "Stalling of DNA replication fork and RPA binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685608", "l": "CLEC2B binds KLRF1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66131", "l": "2-oxobutanoate + L-phenylalanine <=> (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13854", "l": "4-methylene-L-glutamate + ATP + NH4(+) => 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18682", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine => phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0016841", "l": "ammonia-lyase activity", "d": ["Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate."], "t": []}, {"i": "EC:4.3.1.-", "l": "\"Ammonia-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173631", "l": "Activation of C1s (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42455", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate <=> H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603784", "l": "PEX19:class I PMP binds PEX3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670673", "l": "FIX is secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006873", "l": "IL21 receptor STAT binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877187", "l": "P2X7 mediates loss of intracellular K+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61335", "l": "ATP + H2O + indoxyl sulfate(in) <=> ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34544", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592316", "l": "Initial activation of proMMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983259", "l": "Kinesins move along microtubules consuming ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70446", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710914", "l": "ALK fusions bind GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61393", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38433", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167876", "l": "SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43703", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine <=> methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57820", "l": "[phosphate](n) + ADP = [phosphate](n+1) + AMP", "d": [], "t": []}, {"i": "EC:2.7.4.33", "l": "\"AMP-polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39215", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH = hexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.388", "l": "\"glucose-6-phosphate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20968", "l": "L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.25", "l": "\"L-arabinonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856945", "l": "PP2A methylation by LCMT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28899", "l": "glycine(in) + H(+)(in) = glycine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090614", "l": "5'-methylthioadenosine deaminase activity", "d": ["Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42527", "l": "uridine(1911/1915/1917) in 23S rRNA <=> pseudouridine(1911/1915/1917) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16787", "l": "an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11691", "l": "ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66494", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793666", "l": "MDM2 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24044", "l": "3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.8", "l": "\"protocatechuate 4,5-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15831", "l": "a 16beta-hydroxysteroid => a 16alpha-hydroxysteroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70731", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18123", "l": "a thiol + NH4(+) + pyruvate => an S-substituted L-cysteine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63378", "l": "an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.91", "l": "\"tRNA-dihydrouridine(20) synthase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015552", "l": "propionate transmembrane transporter activity", "d": ["Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.32", "l": "\"scytalidopepsin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390912", "l": "HRH1 binds hist (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707523", "l": "Hemes bind to BACH1:MAFK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57184", "l": "L-cysteinyl-[protein] + methylglyoxal = S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30236", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22784", "l": "(2R)-O-phospho-3-sulfolactate = H(+) + phosphoenolpyruvate + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.19", "l": "\"phosphosulfolactate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52879", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25122", "l": "(S)-2-amino-6-oxohexanoate => H(+) + H2O + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390641", "l": "ADRA1A,B,D bind ADR,NAd (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374899", "l": "Release of noradrenaline  at the synapse (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450533", "l": "PKCdelta phosphorylates HuR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68313", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32858", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42233", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264435", "l": "Dissociation of the COP1-p53 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690493", "l": "RHOB binds effectors on endosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70399", "l": "3-oxosphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769394", "l": "AKT phosphorylates CBY1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46187", "l": "3-methylbutanoate + ATP + CoA <=> 3-methylbutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20630", "l": "H2O + O-phospho-L-seryl-[protein] => L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9010872", "l": "SLIT2 binds Dystroglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15561", "l": "S-adenosyl-L-methionine + sterigmatocystin = 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69832", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849094", "l": "ARHGAP35 binds RASA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18838", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA => CoA + taxuyunnanin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810376", "l": "ING2 binds PI5P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035949", "l": "Defective B4GALT1 does not transfer Gal to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48576", "l": "4-chlorocatechol + O2 = 3-chloro-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10415", "l": "ADP-D-ribose + H2O <=> AMP + D-ribose 5-phosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53605", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61595", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31462", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050143", "l": "nocardicin-A epimerase activity", "d": ["Catalysis of the reaction: isonocardicin A = nocardicin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.4", "l": "\"adenosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58800", "l": "3',3'-cGAMP + H2O = 5'-pApG-3' + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877281", "l": "PIAS1 binds p-STAT1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759892", "l": "Expression of BMP4 in lateral plate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67082", "l": "a very long-chain fatty acid(out) + ADP + H(+) + phosphate => a very long-chain fatty acid(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.739291131225258", "identifiers": [{"i": "GO:0016860", "l": "intramolecular oxidoreductase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64123", "l": "an N-(fatty acyl)-L-serine + H2O <=> a fatty acid + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55940", "l": "all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869568", "l": "NPM1 binds TFAP2A homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031826", "l": "type 2A serotonin receptor binding", "d": ["Binding to a type 2A serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933528", "l": "Interaction of MEKK1 with TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30064", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine => H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41249", "l": "9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54383", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 5-hydroxy-alpha-gurjunene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45078", "l": "(9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198669", "l": "p38MAPK phosphorylates MSK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19809", "l": "(S)-ureidoglycolate + 2 H(+) + H2O = CO2 + glyoxylate + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.116", "l": "\"ureidoglycolate amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15877", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate = D-glutamate + pyridoxal 5'-phosphate", "d": [], "t": []}, {"i": "EC:2.6.1.54", "l": "\"pyridoxamine-phosphate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380311", "l": "Recruitment of Plk1 to centrosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0004517", "l": "nitric-oxide synthase activity", "d": ["Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47844", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2399913", "l": "atRAL binds to RBP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193665", "l": "MYD88 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36792", "l": "H2O + N(omega)-hydroxy-L-arginine => hydroxyurea + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444433", "l": "Cho transports from the extracellular space to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047110", "l": "phenylglyoxylate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = benzoyl-CoA + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001094", "l": "TFIID-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46703", "l": "(R)-lipoate + GTP + H(+) <=> (R)-lipoyl-GMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189439", "l": "ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043961", "l": "succinyl-CoA:(R)-citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43135", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13339", "l": "D-glucuronate + H(+) => D-glucurono-6,2-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57419", "l": "H2O + L-asparaginyl-[protein] <=> L-aspartyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67004", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.74", "l": "\"mRNA 5'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38214", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA <=> 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49418", "l": "alpha-D-ribose 1,5-bisphosphate + AMP + H(+) => ADP + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63423", "l": "2-hydroxyethylphosphonate + CTP <=> cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17296", "l": "2 H(+) + NADH + O2 + precorrin-3A <=> H2O + NAD(+) + precorrin-3B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25070", "l": "3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.37", "l": "\"3-hydroxybenzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.41", "l": "\"yapsin 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73453", "l": "adenosine 3',5'-bisphosphate(out) + AMP(in) => adenosine 3',5'-bisphosphate(in) + AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74979", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) = (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730872", "l": "Activation of Calcineurin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43358", "l": "cholesteryl (9Z,12Z)-octadecadienoate(out) => cholesteryl (9Z,12Z)-octadecadienoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102257", "l": "1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity", "d": ["Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O = 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001877", "l": "lipoarabinomannan immune receptor activity", "d": ["Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28523", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004455", "l": "ketol-acid reductoisomerase activity", "d": ["Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28706", "l": "Cu(2+)(in) <=> Cu(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20071", "l": "H2O + phenylacetonitrile => (Z)-phenylacetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043424", "l": "protein histidine kinase binding", "d": ["Binding to a protein histidine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57666", "l": "alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-valencene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25593", "l": "2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": [], "t": []}, {"i": "EC:2.2.1.9", "l": "\"2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018475", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "d": ["Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12977", "l": "H2O + N-phosphocreatine = creatine + phosphate", "d": [], "t": []}, {"i": "EC:3.9.1.1", "l": "\"phosphoamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672162", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61211", "l": "8-nitro-cGMP + L-cysteinyl-[protein] <=> H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835443", "l": "STAT1,STAT3 binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.147", "l": "\"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814374", "l": "Kazrin binds periplakin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112690", "l": "PTPN11 binds CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75862", "l": "Fall Back to Closed Pre-initiation Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43006", "l": "2-aminoprop-2-enoate + CO2 + NH4(+) => H(+) + O-carbamoyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433550", "l": "palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12243", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047424", "l": "methylenediurea deaminase activity", "d": ["Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19672", "l": "GTP + H2O <=> GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19062", "l": "H2O + NADP(+) + nitrite => H(+) + NADPH + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63692", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate = a beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627350", "l": "SMAC (DIABLO) binds XIAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76901", "l": "cyclohexanone + H(+) + NADPH + NH4(+) => cyclohexylamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191303", "l": "FDPS dimer transfers IPPP to GPP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43401", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033040", "l": "sour taste receptor activity", "d": ["Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706837", "l": "AR binds AR antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43085", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49985", "l": "H(+) + jasmonate + NADPH + O2 => (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164617", "l": "Elongation of Extended Telomeric Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57257", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0015424", "l": "ABC-type amino acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61643", "l": "H(+) + isophthalyl-CoA <=> benzoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26555", "l": "angiotensin II + H2O => angiotensin-(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73699", "l": "ADP(in) + dATP(out) = ADP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17566", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33183", "l": "citrate(in) = citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:0016409", "l": "palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56339", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47559", "l": "H2O + taurodeoxycholate <=> deoxycholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769302", "l": "NPAS4 binds INS gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64426", "l": "H(+)(in) + L-leucyl-L-proline(in) => H(+)(out) + L-leucyl-L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944266", "l": "Association of procollagen type XI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949703", "l": "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12748", "l": "a 1,4-lactone + H2O <=> a 4-hydroxyacid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158849", "l": "Phenol can form a sulfate conjugate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49311", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside nLc4Cer(d18:0) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003922", "l": "GMP synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358791", "l": "Phosphorylation of USP8 by P-AKT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75024", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate => 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434989", "l": "SEMA7A binds to PLXNC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34205", "l": "aureusidin 6-O-beta-glucoside + H2O => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56885", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32692", "l": "(2E)-geranyl diphosphate => (E)-beta-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655170", "l": "RCHY1 monoubiquitinates POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351207", "l": "Spermine  => N-acetylated spermine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23280", "l": "acetyl-CoA + cysteamine = CoA + S-acetylcysteamine", "d": [], "t": []}, {"i": "EC:2.3.1.11", "l": "\"thioethanolamine S-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877902", "l": "Activated AR binds RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12572", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28700", "l": "Mn(2+)(in) => Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264622", "l": "Cho is acetylated to AcCho by CHAT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694718", "l": "O-glycosylation of 3a is terminated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373024", "l": "isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047375", "l": "N-acetylgalactosaminoglycan deacetylase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72267", "l": "chloride(out) + formate(in) = chloride(in) + formate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52189", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59111", "l": "chenodeoxycholate + octyl beta-D-glucose <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24540", "l": "A + D-glucose = AH2 + D-glucono-1,5-lactone", "d": [], "t": []}, {"i": "EC:1.1.99.35", "l": "\"soluble quinoprotein glucose dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19891", "l": "diphosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71474", "l": "H2O + substance P <=> L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25061", "l": "(E)-cinnamate + H(+) + NADH + O2 <=> (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008884", "l": "glutathionylspermidine amidase activity", "d": ["Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10204", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] = formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.5.8.1", "l": "\"dimethylamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45500", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37148", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36912", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28306", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.251", "l": "\"GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433506", "l": "Phosphorylation of APS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22748", "l": "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445714", "l": "Aquaporin-3 passively transports water out of cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031832", "l": "type 6 serotonin receptor binding", "d": ["Binding to a type 6 serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57438", "l": "acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaethol + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41728", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034927", "l": "pyrene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76297", "l": "methylcob(III)alamin + S-adenosyl-L-homocysteine => cob(I)alamin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39624", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16571", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[collagen] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391150", "l": "p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17261", "l": "an aryl sulfate + H2O = a phenol + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.1", "l": "\"arylsulfatase (type I)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004859", "l": "phospholipase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42761", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73178", "l": "ADP(in) + FMN(out) <=> ADP(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15781", "l": "L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate", "d": [], "t": []}, {"i": "EC:5.4.3.6", "l": "\"tyrosine 2,3-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45768", "l": "gamma-L-glutamyl-L-alaninol + H2O = L-alaninol + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71003", "l": "L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965450", "l": "DAAM1 recruits PFN1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68925", "l": "ATP + H(+) + hexanoate + NADPH => AMP + diphosphate + hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21086", "l": "dermatan 4'-sulfate => chondroitin 4'-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41397", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17811", "l": "Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine => Mg-protoporphyrin IX + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106625", "l": "Duplex siRNA is loaded into Argonaute (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.2", "l": "\"alcohol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47694", "l": "5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B => AH2 + neomycin C + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76215", "l": "2'-deoxyguanosine(in) = 2'-deoxyguanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33168", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42579", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O <=> 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018567", "l": "styrene dioxygenase activity", "d": ["Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25315", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11768", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": [], "t": []}, {"i": "EC:2.4.2.18", "l": "\"anthranilate phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57217", "l": "dGTP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193668", "l": "p75NTR and RHOA-GDI interact (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204850", "l": "Interaction of Tie2 and Dok-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904841", "l": "TORC2 complex binding", "d": ["Binding to a TORC2 complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106326", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28403", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373724", "l": "Nephrin binds NCK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77632", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12448", "l": "(R)-pantothenate + H2O = (R)-pantoate + beta-alanine", "d": [], "t": []}, {"i": "EC:3.5.1.22", "l": "\"pantothenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76344", "l": "(2S)-2-isopropylmalate(in) + sulfate(out) => (2S)-2-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71229", "l": "2 Na(+)(in) + selenocyanate(in) => 2 Na(+)(out) + selenocyanate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18546", "l": "2-dehydro-3-deoxy-L-arabinonate => glycolaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140815", "l": "NAD+-protein-histidine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:72071", "l": "L-histidyl-[protein] + NAD(+) = H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784189", "l": "JAKs bind LIFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953452", "l": "E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53006", "l": "2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045548", "l": "phenylalanine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60266", "l": "H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40246", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0032135", "l": "DNA insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing an insertion or a deletion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944214", "l": "Association of procollagen type I (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951951", "l": "RUNX3 binds EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451347", "l": "Activation of JNK by DSCAM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40288", "l": "ATP + CoA + decanedioate => AMP + decanedioyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.126200859969501", "identifiers": [{"i": "GO:0017171", "l": "serine hydrolase activity", "d": ["Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43201", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669012", "l": "EDA binds EDAR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59787", "l": "H2O + NADP(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062148", "l": "L-gamma-glutamyl-L-propargylglycine hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate."], "t": []}, {"i": "RHEA:59900", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851352", "l": "CCR8 binds CCL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.7", "l": "\"asclepain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022875", "l": "protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52328", "l": "L-arginine + O2 + reduced [flavodoxin] = H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35471", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.270", "l": "\"(+)-6a-hydroxymaackiain 3-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61937", "l": "ATP + cycloheximide(in) + H2O => ADP + cycloheximide(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54071", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + sesterfisherol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70610", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol <=> 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29214", "l": "H(+)(out) + inosine(in) <=> H(+)(in) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49915", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44852", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45197", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] => 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140397", "l": "versiconal hemiacetal acetate esterase activity", "d": ["Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804879", "l": "MDM2 ubiquitinates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54048", "l": "(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.170", "l": "\"4-epi-cubebol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36924", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429992", "l": "PARN deadenylates mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18521", "l": "licodione + S-adenosyl-L-methionine = 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.65", "l": "\"licodione 2'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617828", "l": "TRIP11:IFT20 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034842", "l": "thiophene-2-carboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10108", "l": "(7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine", "d": [], "t": []}, {"i": "EC:1.1.1.248", "l": "\"salutaridine reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68760", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672980", "l": "Dissociation of RAS:RAF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39081", "l": "3-oxododecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydodecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29791", "l": "ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.10", "l": "\"ABC-type glutathione transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016750", "l": "O-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10189", "l": "acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203977", "l": "SAR1 Activation And Membrane Binding (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.578880498257753", "identifiers": [{"i": "GO:0015291", "l": "secondary active transmembrane transporter activity", "d": ["Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24308", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50428", "l": "methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.334", "l": "\"methanethiol S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38905", "l": "a sphingomyelin(out) + ADP + H(+) + phosphate => a sphingomyelin(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64159", "l": "an N-(fatty acyl)-L-methionine + H2O <=> a fatty acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75856", "l": "Abortive Initiation Before Second Transition (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62427", "l": "(E)-caffeoyl-CoA + H2O <=> 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798138", "l": "TP53 binds the CASP10 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814409", "l": "CK2 phosphorylates PDCL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38151", "l": "carbonyl sulfide + H2O = CO2 + H(+) + hydrogen sulfide", "d": [], "t": []}, {"i": "EC:3.13.1.7", "l": "\"carbonyl sulfide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72240", "l": "estrone 3-sulfate(out) + L-glutamate(in) => estrone 3-sulfate(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61315", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0160008", "l": "protein decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]."], "t": []}, {"i": "RHEA:69172", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69707", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-galactose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604732", "l": "Autocatalytic activation of proMMP13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68061", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67074", "l": "a very long-chain fatty acid + CoA + H(+) => a very long-chain fatty acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050528", "l": "acyloxyacyl hydrolase activity", "d": ["Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11002", "l": "a D-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-D-amino acid + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70259", "l": "AMP(out) + phosphate(in) = AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640195", "l": "RRAGA,B hydrolyzes GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67899", "l": "a 3'-end uridylyl-adenosine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69368", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177934", "l": "EGFR autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70968", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) => 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31626", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine <=> H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061657", "l": "UFM1 conjugating enzyme activity", "d": ["Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32446", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43504", "l": "5-hydroxymethylfurfural + O2 = 2,5-diformylfuran + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72285", "l": "a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35765", "l": "aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33561", "l": "a 2-acyl-sn-glycerol 3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76533", "l": "H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate => H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30057", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADPH => L-allo-threonine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77017", "l": "1-hydroxy-4-methylpentan-2-one + H(+) + NADH + NH4(+) => (S)-leucinol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37342", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O <=> (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43659", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010294", "l": "abscisic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57838", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + thermospermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109700", "l": "AKT2 binds PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48540", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51079", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43654", "l": "3-oxododecanoyl-[ACP] + CO2 + CoA => decanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213244", "l": "Loading of antigenic peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696271", "l": "RND1 binds effectors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64302", "l": "3-phenylpropanal + L-alanine => 3-phenylpropylamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13893", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.29", "l": "\"bis(5'-adenosyl)-triphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050627", "l": "mycothione reductase activity", "d": ["Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879910", "l": "JAK2 is phosphorylated, activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35507", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686578", "l": "Activated ATM phosphorylates ABL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49276", "l": "CTP + phytyl phosphate = CDP + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18151", "l": "acetate + D-galactosamine 6-phosphate => H2O + N-acetyl-D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14173", "l": "dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.34", "l": "\"4-dimethylallyltryptophan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64290", "l": "cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832823", "l": "POU3F1 and ZNF521 bind the PAX6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50570", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950201", "l": "Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61728", "l": "a 3-dehydro-D-guloside = a 3-dehydro-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30974", "l": "7,7',9,9'-tetra-cis-lycopene <=> all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39826", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38881", "l": "a fatty acid(out) => a fatty acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683774", "l": "p-T68-CHEK2 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420206", "l": "Phosphorylation of SRC-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34853", "l": "3-oxoadipyl-CoA + H(+) + NADH => (3S)-3-hydroxyadipyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33654", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA <=> (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21159", "l": "(2R)-2-phosphoglycerate + H2O <=> (R)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76039", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102527", "l": "8-demethylnovobiocate synthase activity", "d": ["Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) = H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12492", "l": "L-methionine = D-methionine", "d": [], "t": []}, {"i": "EC:5.1.1.2", "l": "\"methionine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936851", "l": "AHRR binds ARNT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48589", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76938", "l": "2-methylpropan-1-amine + H2O + NAD(+) <=> 2-methylpropanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19946", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033284", "l": "ATPase-coupled carboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549385", "l": "CRY:PER:Kinase complex translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68035", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68786", "l": "diphosphate + gamma-curcumene => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38019", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35450", "l": "(1'S)-averantin + NADP(+) <=> H(+) + NADPH + norsolorinic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38441", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26560", "l": "(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48651", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74516", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B => aspoquinolone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76211", "l": "GMP(in) = GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668789", "l": "LA,TNFSF14 binds LTBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46649", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => androst-4-ene-3,17-dione + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13492", "l": "(S)-canadine + H(+) + 2 O2 <=> berberine + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75089", "l": "32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474210", "l": "Collagen type III degradation by MMP14 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75737", "l": "10-oxo-(11E)-octadecenoate => 10-oxo-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68616", "l": "cortisone + H(+) + NADPH = cortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23178", "l": "acetyl-CoA + AMP + diphosphate => acetate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36666", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA <=> (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21889", "l": "(1S,2S)-OPC-8 + NADP(+) => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58426", "l": "(E)-hex-2-enal + H(+) + NADPH => (E)-hex-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29580", "l": "Fe(2+)(in) + H(+)(in) => Fe(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43846", "l": "(3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+) => (3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19382", "l": "(S)-oxalosuccinate + H(+) => 2-oxoglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682709", "l": "LGI4 binds ADAM22,23,11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404142", "l": "atROL binds RBP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34017", "l": "ergosterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50848", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917841", "l": "Acidification of Tf:TfR1 containing endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27386", "l": "H2O + maleamate => maleate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38975", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67120", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49009", "l": "aurachin C + H(+) + NADPH + O2 => aurachin C epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.22", "l": "\"carbazole 1,9a-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388830", "l": "PI3K binds ICOS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102501", "l": "D-fructuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985594", "l": "MYO9B inactivates RHOA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16519", "l": "aminoacetone + H(+) + NADH => (R)-1-aminopropan-2-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815510", "l": "MIB2 binds CYLD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36779", "l": "2-oxoglutarate + GDP-alpha-D-perosamine = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.102", "l": "\"GDP-perosamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36232", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23599", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose <=> 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016696", "l": "oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP."], "t": []}, {"i": "EC:1.12.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109639", "l": "Formation of the closed pre-initiation complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610735", "l": "NUMB binds ITCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032794", "l": "GTPase activating protein binding", "d": ["Binding to a GTPase activating protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11186", "l": "beta-alanine + CO2 + NH4(+) => 3-(carbamoylamino)propanoate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10364", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.4", "l": "\"decylhomocitrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032843", "l": "hydroperoxide reductase activity", "d": ["Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754129", "l": "CDK6 inhibitors bind CDK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836275", "l": "TFAP2A binds TFAP2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202472", "l": "Translocation of TRAF6 to CBM complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218804", "l": "p38 MAPK activation by VEGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17552", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703439", "l": "FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047550", "l": "2-oxoadipate reductase activity", "d": ["Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250930", "l": "B-WICH recruits histone acetyltransferases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17061", "l": "H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.7", "l": "\"phenol 2-monooxygenase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53147", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419389", "l": "LPA-binding receptors bind LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102474", "l": "eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose = 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33838", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029270", "l": "Recruitment of PLCgamma to membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944246", "l": "Association of procollagen type XXI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24343", "l": "(R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10594", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050160", "l": "orsellinate-depside hydrolase activity", "d": ["Catalysis of the reaction: H2O + orsellinate depside = 2 o-orsellinate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67518", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76052", "l": "(S)-scoulerine + S-adenosyl-L-methionine => (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47185", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218836", "l": "PTK2beta binds alphaVbeta3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180004", "l": "RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014296", "l": "RAC2 GEFs activate RAC2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77208", "l": "3'-phosphoadenylyl sulfate + glycodeoxycholate => 3alpha-sulfoglycodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008455", "l": "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373747", "l": "Phosphorylation of nephrin by FYN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53578", "l": "20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013110", "l": "RHOC binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36941", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961688", "l": "E2F1 binds the FBXO5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632892", "l": "TP53 stimulates transcription of RRM2B gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66074", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24966", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0033549", "l": "MAP kinase phosphatase activity", "d": ["Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9833973", "l": "ISGylation of PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54171", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46224", "l": "(E)-feruloyl-CoA + H2O = (E)-ferulate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63450", "l": "CMP-(2-aminoethyl)phosphonate + diphosphate => (2-aminoethyl)phosphonate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61313", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40687", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol = 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65443", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73446", "l": "2-oxoglutarate + gardenin B + O2 <=> CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17305", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45169", "l": "2 (E)-sinapoyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696491", "l": "CNTF binds CNTFR complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35469", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+) => (6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74027", "l": "L-alanine(in) + L-threonine(out) = L-alanine(out) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22841", "l": "D-glutamine + H2O => D-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693598", "l": "ATM phosphorylates NBN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23773", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73268", "l": "H(+)(out) + L-methionine(in) => H(+)(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019237", "l": "centromeric DNA binding", "d": ["Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52425", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24594", "l": "CDP-ethanolamine + diphosphate => CTP + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672948", "l": "MARK3 phosphorylates KSR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9707683", "l": "PGRMC2 binds Hemes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139895", "l": "tBID activates BAK protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74526", "l": "L-lysine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59970", "l": "CoA + O-octanoyl-L-threonyl-[protein] => L-threonyl-[protein] + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28324", "l": "UDP + wogonin 7-O-beta-D-glucuronate => UDP-alpha-D-glucuronate + wogonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375140", "l": "CDO binds promyogenic cadherins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33439", "l": "glyoxal + H2O + O2 = glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44198", "l": "3-methylundecanoyl-CoA + AMP + diphosphate => 3-methylundecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940554", "l": "MMP2 cleaves OPTC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74604", "l": "CMP(out) + UDP-alpha-D-galactose(in) => CMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32735", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25818", "l": "3-aminopropanal + H2O2 + norspermidine => H2O + norspermine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222237", "l": "SMYD2 methylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9010815", "l": "SLITs bind keratan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42052", "l": "9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791167", "l": "Expression of SERP1 (RAMP4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74914", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] <=> a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11902", "l": "2-oxoadipate + CO2 + NADH => (2R,3S)-homoisocitrate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27486", "l": "allantoate + 2 H(+) + H2O => (S)-2-ureidoglycine + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19650", "l": "ATP + L-aspartate + tRNA(Asp) => AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508292", "l": "SYK binds IL2RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63821", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + petrobactin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59552", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 = H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192925", "l": "Export of Spliced Viral mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30557", "l": "GDP + H(+) + oxidized coenzyme F420-1 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0050145", "l": "nucleoside monophosphate kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46940", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] = ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870465", "l": "RGGT binds the RAB-binding subunit (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48617", "l": "H2O + leukotriene D4 => glycine + leukotriene E4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404144", "l": "Parenchymal atROL translocates to HSCs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831677", "l": "M dimer gets exported from nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18335", "l": "ADP + H(+) + oleandomycin 2'-O-phosphate => ATP + oleandomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0043175", "l": "RNA polymerase core enzyme binding", "d": ["Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49397", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.490486312819655", "identifiers": [{"i": "GO:0016774", "l": "phosphotransferase activity, carboxyl group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613497", "l": "Unwinding DNA for the nascent transcript (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52215", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.050016418185038", "identifiers": [{"i": "GO:0004386", "l": "helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22105", "l": "2-oxoglutarate + nicotianamine => 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55231", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75850", "l": "Addition of the third nucleotide on the nascent transcript (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21081", "l": "ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10223", "l": "ATP + L-tyrosine + tRNA(Tyr) <=> AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878117", "l": "RUNX3 binds ZFHX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690449", "l": "S1PR1 bind S1P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033408", "l": "UCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59158", "l": "AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20282", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate => (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53766", "l": "allocholoyl-CoA + lithocholate => allocholate + lithocholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58517", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75014", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate <=> 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109702", "l": "PDPK1 phosphorylates AKT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265166", "l": "Exocytosis of Insulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63758", "l": "flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP => flavokermesate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981622", "l": "Myoglobin:oxygen dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9680443", "l": "ROCK1,2 bind ROCKi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668545", "l": "NIK autophosphorylates on T559 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26487", "l": "H(+) + O-phospho-L-serine + sulfite => L-cysteate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046574", "l": "glycuronidase activity", "d": ["Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0005375", "l": "copper ion transmembrane transporter activity", "d": ["Enables the transfer of copper (Cu) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17360", "l": "O2 + 2 R'C(R)SH <=> H2O2 + R'C(R)S-S(R)CR'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17611", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine => L-seryl-[sulfatase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60039", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate <=> 3-hydroxy-3-methylhexanoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43502", "l": "D-glucaro-1,5-lactone + H(+) + NADH => beta-D-glucuronate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75152", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + neoverrucosan-5beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937369", "l": "ATAD2 binds ESR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008460", "l": "dTDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64499", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] <=> 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103064", "l": "inositol phosphorylceramide mannosyltransferase activity", "d": ["Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42176", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434989", "l": "SEMA7A binds to PLXNC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39756", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34771", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72478", "l": "cis-aconitate(in) + citrate(out) <=> cis-aconitate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0106017", "l": "phosphatidylinositol-3,4-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662620", "l": "MT3 binds cadmium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213207", "l": "Formation of collagen networks (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610388", "l": "HCMV translocates from the endosome lumen to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32191", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73886", "l": "guanidine(out) <=> guanidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23176", "l": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.1", "l": "\"acetate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202291", "l": "Activation of Lck (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45519", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655142", "l": "RCHY1 binds POLH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60417", "l": "diglucosyl-enterobactin + H2O => H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53821", "l": "chenodeoxycholate + NADP(+) => 7-oxolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32233", "l": "ADP + H(+) + NADPH + phosphate => (6S)-NADPHX + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392852", "l": "Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22770", "l": "4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one => 4-nitrophenyl-3-ketovalidamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679819", "l": "TBK1 binds amlexanox (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13695", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+) => (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990649", "l": "inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389532", "l": "PP2A binds CTLA4 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44042", "l": "14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730862", "l": "Autophosphorylation of LYN kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602170", "l": "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67440", "l": "H2O + N(alpha)-acetyl-L-methionine = acetate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674529", "l": "AAMP binds to TBXA2R (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031715", "l": "C5L2 anaphylatoxin chemotactic receptor binding", "d": ["Binding to a C5L2 anaphylatoxin chemotactic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16762", "l": "chlorohydroquinone + O2 => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15679", "l": "5-aminopentanoate + NH4(+) => 5-aminopentanamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939204", "l": "ESTG binds ESR1:chaperone complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39097", "l": "3-oxodecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51300", "l": "(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65287", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate <=> 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15972", "l": "2 glutathione + H(+) + methylarsonate <=> glutathione disulfide + H2O + methylarsonous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204863", "l": "Interaction of Tie2 with Ang2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70962", "l": "D-tyrosine + H2O + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62013", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855212", "l": "1/3-PP-IP5 transports from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55825", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d => a bacteriochlorophyllide f + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47257", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980044", "l": "NOTCH1 binds JAG2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39245", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+) => (11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25425", "l": "diphosphate + GMP => 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39274", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA <=> (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42270", "l": "4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA => 2-methylpropanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56013", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034836", "l": "6-hydroxy-2-mercaptobenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173740", "l": "Factor B binds to C3(H2O) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0015091", "l": "ferric iron transmembrane transporter activity", "d": ["Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013568", "l": "HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297275", "l": "CD9:Izumo Binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70602", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76657", "l": "3-methylbutanoate + 2 H(+) + NADH => 3-methylbutanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019909", "l": "[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity", "d": ["Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38174", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA <=> 2-hydroxyhexadecyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0090369", "l": "ornithine carbamoyltransferase inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793375", "l": "Expression of MSGN1 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11531", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12433", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75170", "l": "CTP + NAD(+) <=> CDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65089", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55597", "l": "a globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine => a globoside NORint + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52372", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68508", "l": "(2E,6E)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854466", "l": "VLDLR binds RELN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14479", "l": "a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75358", "l": "H2O + L-mimosine <=> 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.213", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41139", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51013", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O => a monoacylglycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26459", "l": "ethylnitronate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12548", "l": "2-cis,4-trans-xanthoxin + NAD(+) = 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.288", "l": "\"xanthoxin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46082", "l": "NAD(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76100", "l": "a dicarboxylate(in) + xanthurenate(out) => a dicarboxylate(out) + xanthurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202721", "l": "JAM2 binds JAM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046424", "l": "ferulate 5-hydroxylase activity", "d": ["Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.282", "l": "\"phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690873", "l": "ACO1 binds 4Fe-4S (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875591", "l": "DOCK7 activates RAC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757438", "l": "ASA- translocates from cytosol to ER lumen of GI cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201639", "l": "Caspase-mediated cleavage of GAS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16595", "l": "3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30368", "l": "adenosylcob(III)alamin 5'-phosphate + H2O => adenosylcob(III)alamin + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59837", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19323", "l": "formaldehyde + N-methylaniline => N,N-dimethylaniline N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209891", "l": "Dopamine is oxidised to noradrenaline (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213201", "l": "Formation of collagen fibres (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18817", "l": "acetyl-CoA + malonate = acetate + malonyl-CoA", "d": [], "t": []}, {"i": "EC:2.8.3.3", "l": "\"malonate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651773", "l": "LIG1 binds POLB at long-patch BER site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49322", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-violaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68367", "l": "4-CDP-2-C-methyl-D-erythritol <=> 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74243", "l": "H2O + L-alanyl-tRNA(Pro) = H(+) + L-alanine + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74273", "l": "a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+) => an alpha-Kdo-(2->6)-lipid IVA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21063", "l": "3,4-dichloroaniline + malonyl-CoA <=> CoA + N-(3,4-dichlorophenyl)malonamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16524", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950362", "l": "EBI3:CANX binds IL12A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42882", "l": "H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54308", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26185", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050232", "l": "putrescine oxidase activity", "d": ["Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799761", "l": "TP53 binds PPP1R13L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102680", "l": "campest-4-en-3-one hydroxylase activity", "d": ["Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH = (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31565", "l": "L-glutamate + leukotriene D4 => H2O + leukotriene C4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698007", "l": "FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55604", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70312", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420265", "l": "AMY1-3 bind IAPP(34-70) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39035", "l": "an omega-hydroxy fatty acid + NAD(+) = an omega-oxo fatty acid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35381", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45736", "l": "(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68807", "l": "H2O + kojibiose <=> alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22108", "l": "L-threonine = 2-oxobutanoate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.19", "l": "\"threonine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29234", "l": "cyanate(in) <=> cyanate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.27", "l": "\"sphinganine-1-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72044", "l": "L-glutamate(in) + orotate(out) => L-glutamate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683925", "l": "ULK1 is dephosphorylated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52173", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41452", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 = 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.189", "l": "\"5-methyl-1-naphthoate 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102865", "l": "delta6-acyl-lipid desaturase activity", "d": ["Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16345", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.167", "l": "\"dolabella-3,7-dien-18-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171106", "l": "LDLR:LDL complex => LDLR + LDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44334", "l": "ADP + bacilysin + H(+) + phosphate => ATP + L-alanine + L-anticapsin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693783", "l": "NAALADases hydrolyse NAAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013159", "l": "CDC42 GEFs activate CDC42 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41537", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32574", "l": "(E)-2-methylgeranyl diphosphate + H2O <=> 2-methylisoborneol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15684", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) <=> (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66674", "l": "5,7-dihydroxy-4-methylphthalide + H2O => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210694", "l": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683801", "l": "CHEK2 phosphorylates BRCA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871266", "l": "YAP1 binds TEAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627056", "l": "Procaspase 9 forms dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59929", "l": "erythritol + NADP(+) => D-erythrose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77547", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70688", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13175", "l": "H(+) + NADH + phosphate => H2O + NAD(+) + phosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052642", "l": "lysophosphatidic acid phosphatase activity", "d": ["Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21082", "l": "diphosphate + phosphate + S-adenosyl-L-methionine => ATP + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032582", "l": "Activated FYN binds GRIN2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633295", "l": "TP53 binds the NDRG1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33764", "l": "a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762345", "l": "PREDN:ALB dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38436", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164503", "l": "First strand transfer mediated by Repeated (R) sequence (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004109", "l": "coproporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40527", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) = 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": [], "t": []}, {"i": "EC:7.1.1.7", "l": "\"ubiquinol oxidase (electrogenic, proton-motive force generating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48324", "l": "a ganglioside GD1b + GDP-beta-L-fucose = a ganglioside Fuc-GD1b + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380198", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20048", "l": "3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + malonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19234", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] => H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52465", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76248", "l": "ATP + ergothioneine(out) + H2O => ADP + ergothioneine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004164", "l": "diphthine synthase activity", "d": ["Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H+ + 3 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033996", "l": "levan fructotransferase (DFA-IV-forming) activity", "d": ["Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047228", "l": "1,2-diacylglycerol 3-glucosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17150", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] => an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16383", "l": "H(+) + L-xylulose + NADH => L-arabinitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664850", "l": "ATM binds PEX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55358", "l": "13-cis-retinol => 11-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35027", "l": "ATP + H2O + tungstate(in) = ADP + H(+) + phosphate + tungstate(out)", "d": [], "t": []}, {"i": "EC:7.3.2.6", "l": "\"ABC-type tungstate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199456", "l": "PTEN dephosphorylates PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983153", "l": "E1 mediated ubiquitin activation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20606", "l": "cytosine + H(+) + H2O => NH4(+) + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759731", "l": "SNAI1 binds the OCLN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202969", "l": "Caspase mediated cleavage of beta-catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.165", "l": "\"chlorophyllide a 3(1)-hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944242", "l": "Association of procollagen type XXVII (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190258", "l": "FGFR2c binds to FGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56827", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 <=> A + cyclooctatin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38081", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64192", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine = (9Z)-octadecenoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33815", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate = 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.44", "l": "\"teichoic acid glycerol-phosphate primase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103079", "l": "2-(3'-methylthio)propylmalate synthase activity", "d": ["Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O = H+ + 2-(3-methylthiopropyl)malate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28522", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.83", "l": "\"D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734687", "l": "ORC6 is phosphorylated on T195 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43534", "l": "a ribonucleoside 5'-phosphate + phosphate => a ribonucleoside 3',5'-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0043621", "l": "protein self-association", "d": ["Binding to a domain within the same polypeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15362", "l": "a dolichyl phosphate + UDP-alpha-D-xylose => a dolichyl D-xylosyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071889", "l": "14-3-3 protein binding", "d": ["Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20634", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine => a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56421", "l": "apo-[D-alanyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64120", "l": "an N-(fatty acyl)-L-serine + H2O = a fatty acid + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-378975", "l": "Follitropin is a heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944236", "l": "Association of procollagen type XIV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28064", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66355", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981621", "l": "C3 convertases spontaneously dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696358", "l": "TREM,CD300 binds lipids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176298", "l": "Activation of claspin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71967", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54426", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide => L-aspartyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64063", "l": "(S)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15911", "l": "aminoacetaldehyde + CO2 + H(+) + succinate + sulfite => 2-oxoglutarate + O2 + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975878", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46379", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75915", "l": "H2O + NAD(+) + serinol = dihydroxyacetone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23089", "l": "ATP + O-alkylglycerone => 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429449", "l": "Syk activation leads to SLP-76 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50556", "l": "prostaglandin D2 = H2O + prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34250", "l": "1-deoxymethyl-sphinganine + NADP(+) <=> 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71038", "l": "L-phenylalanine(out) + L-serine(in) <=> L-phenylalanine(in) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70840", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) => L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791156", "l": "Expression of TATDN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38302", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34266", "l": "dimethylallyl diphosphate + fumigaclavine A <=> diphosphate + fumigaclavine C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21769", "l": "H2O + N-methyl-L-alanine + NADP(+) => H(+) + methylamine + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938930", "l": "RUNX1 binds ELF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047557", "l": "3-aci-nitropropanoate oxidase activity", "d": ["Catalysis of the reaction: 3-aci-nitropropanoate + H2O + O2 = 3-oxopropanoate + H2O2 + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19379", "l": "2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17576", "l": "demethylmacrocin + S-adenosyl-L-methionine <=> H(+) + macrocin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443418", "l": "GP1b signaling involves c-Src (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666428", "l": "DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938913", "l": "RUNX1 binds ELF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36188", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42189", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696547", "l": "STAMBPL1 is a deubiquitinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357432", "l": "AXL binds SRC-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051921", "l": "adenosylcobyric acid synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H+ + 4 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37254", "l": "cysteamine S-phosphate + H2O <=> cysteamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74318", "l": "O-isobutanoyl-(R)-carnitine(in) <=> O-isobutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45629", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64580", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + nerylneryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55455", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74242", "l": "phosphate + solabiose <=> alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660822", "l": "ATP binds P2RX4,7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74976", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] => a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70855", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) = L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73994", "l": "geranylgeranyl diphosphate <=> beta-araneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60229", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24362", "l": "Fe(2+) + sirohydrochlorin => 2 H(+) + siroheme", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50676", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-[protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.121", "l": "\"protein N-terminal asparagine amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32551", "l": "(2E)-geranyl diphosphate + H2O = (S)-alpha-terpineol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.111", "l": "\"(-)-alpha-terpineol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46485", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40748", "l": "2-oxoglutarate + L-lysine + O2 => (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.55", "l": "\"4-hydroxybenzoate brominase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674385", "l": "p-T,Y MAPKs dimerize (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44677", "l": "a triacyl-sn-glycerol + all-trans-retinol => a diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76991", "l": "H(+) + NAD(+) + reduced 2[4Fe-4S]-[ferredoxin] = NADH + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.2", "l": "\"aminopyrimidine aminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928657", "l": "MMP2,9 cleave EPHB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54111", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + guaia-4,6-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23585", "l": "7,8-dihydropteroate + ATP + L-glutamate => 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73271", "l": "rhamnetin + S-adenosyl-L-methionine = H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209823", "l": "Tyrosine is hydroxylated to dopa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51206", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => 6-trans-leukotriene B4 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334827", "l": "SUMO-CRABP2 binds atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77336", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP-alpha-D-mannose => alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676229", "l": "WIPIs bind PI3P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252133", "l": "ATP6AP1 binds V-ATPase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55723", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481009", "l": "Exocytosis of platelet dense granule content (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791056", "l": "Expression of CCL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46155", "l": "15-cis-phytoene + a plastoquinone <=> 15,9'-di-cis-phytofluene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177942", "l": "EGFR binds EGF ligand (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47325", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate => 3-oxo-3-phenylpropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32024", "l": "(2E,6E)-farnesyl diphosphate + H2O => avermitilol + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43748", "l": "ATP + CoA + hexacosanoate = AMP + diphosphate + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16591", "l": "3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2 => A + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24871", "l": "5-deoxy-alpha-D-ribose 1-phosphate + adenine => 5'-deoxyadenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045027", "l": "DNA end binding", "d": ["Binding to DNA ends exposed by the creation of double-strand breaks (DSBs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58202", "l": "6-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18445", "l": "H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}, {"i": "EC:3.5.4.10", "l": "\"IMP cyclohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373748", "l": "SEMA4D interacts with CD72 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617179", "l": "PRKACA phosphorylates TNNI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674093", "l": "PDGFRs bind type I TKI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52985", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] => 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47740", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.130", "l": "\"2-carboxy-1,4-naphthoquinone phytyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72545", "l": "2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in) => 2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67298", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2 => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32187", "l": "cholest-5-en-3-one = cholest-4-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111956", "l": "Calmodulin activates Cam-PDE 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43657", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74436", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) => a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237160", "l": "MTA is cleaved and phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76030", "l": "(S)-reticuline + 2-oxoglutarate + O2 <=> (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389762", "l": "Phosphorylation of PD-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48286", "l": "a globoside NOR1 (d18:1(4E)) + H(+) + UDP => a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37128", "l": "2-oxoglutarate + dioxidophosphate + H2O2 => CO2 + H(+) + phosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418925", "l": "ADORA2A,B bind Ade-Rib (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2482180", "l": "Collagen type VIII degradation by ELANE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60960", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55021", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O => 5,6-diaminouracil + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18596", "l": "sphinganine 1-phosphate <=> hexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24689", "l": "H2O + N-formylmethanofuran <=> formate + methanofuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68457", "l": "(S)-3-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810076", "l": "DDO oxidizes D-Asp to OA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67064", "l": "AH2 + asnovolin K = A + asnovolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11943", "l": "2 H(+) + H2O + L-citrulline <=> CO2 + L-ornithine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419223", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75463", "l": "choline(out) + n H(+)(in) = choline(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810843", "l": "Envoplakin binds periplakin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72581", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45281", "l": "12-(phosphooxy)octadecanoate + H2O => 12-hydroxyoctadecanoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202203", "l": "Recruitment of PI3K to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047931", "l": "glucosamine kinase activity", "d": ["Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47303", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350769", "l": "trans-Golgi Network Coat Activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734475", "l": "PPARA binds fibrates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76284", "l": "guanine(out) + Na(+)(out) => guanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76819", "l": "D-aspartate + H2O + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71976", "l": "glutathione(out) + 3 Na(+)(out) => glutathione(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931981", "l": "RUNX1 binds ESR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804276", "l": "ATM phosphorylates TTC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645598", "l": "RRAGC,D hydrolyzes GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788999", "l": "HV1-mediated H+ transfer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754964", "l": "ADA deamidates RBV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001072", "l": "galactomannan binding", "d": ["Binding to galactomannan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19820", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036380", "l": "UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140842", "l": "n fibrin monomers -> fibrin multimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50228", "l": "FADH2 + O2 + resorcinol = benzene-1,2,4-triol + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.27", "l": "\"resorcinol 4-hydroxylase (FADH2)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39124", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37502", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199154", "l": "CD200 binds to CD200R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.-", "l": "\"With ascorbate as one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53851", "l": "NAD(+) + taurocholate <=> 7-oxo-taurodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42803", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) <=> all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12081", "l": "acetyl-CoA + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783530", "l": "gp130:JAKs bind CNTFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18655", "l": "3-oxo-3-ureidopropanoate => barbiturate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.94", "l": "\"glucan 1,6-alpha-isomaltosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170016", "l": "endoplasmic reticulum-endosome tether activity", "d": ["The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48192", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211983", "l": "CYP2J2 oxidises ARA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008726", "l": "alkanesulfonate monooxygenase activity", "d": ["Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41920", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51533", "l": "H(+) + NADPH + O2 + urate => 5-hydroxyisourate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24568", "l": "a 6-phospho-beta-D-galactoside + H2O = an alcohol + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10667", "l": "NAD(+) + perillyl alcohol <=> H(+) + NADH + perillyl aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22585", "l": "2 H(+) + heme b => Fe(2+) + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102541", "l": "D-galactose 6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34350", "l": "(2E)-geraniol + NAD(+) <=> (2E)-geranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3321883", "l": "MSL acetylates histone H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858500", "l": "CLEC10A binds Tn-MUC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649856", "l": "Oxidative damage to the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47042", "l": "5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => 5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37666", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40933", "l": "(3S)-3-hydroxy-L-ornithine + CO2 + succinate => 2-oxoglutarate + L-ornithine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72479", "l": "citrate(out) + trans-aconitate(in) = citrate(in) + trans-aconitate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350769", "l": "trans-Golgi Network Coat Activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34106", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10574", "l": "(2E)-butenoyl-CoA => vinylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74568", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) => L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209298", "l": "BSK is phosphorylated and activated by phosphorylated HEP kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74463", "l": "(-)-4'-methoxycyclopenine = 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22690", "l": "H2O2 + NH4(+) + pyruvate => D-alanine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814088", "l": "SYS1 binds AcM-ARFRP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389756", "l": "AKT interacts and phosphorylates Cot (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76277", "l": "Na(+)(in) + uracil(in) => Na(+)(out) + uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043210", "l": "alkanesulfonate binding", "d": ["Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32188", "l": "cholest-5-en-3-one => cholest-4-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19583", "l": "discadenine + H(+) + S-methyl-5'-thioadenosine => N(6)-dimethylallyladenine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64975", "l": "dUDP + H2O <=> dUMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15124", "l": "dithioerythritol + thiosulfate <=> cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35783", "l": "neamine + UDP-alpha-D-kanosamine = H(+) + kanamycin B + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27466", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) => ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801762", "l": "REG3A oligomerize to form a pore complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392263", "l": "AVP(20-28) binds AVPR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156682", "l": "PLK1 phosphorylates NUDC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73568", "l": "ITP(out) + UTP(in) => ITP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31548", "l": "2 (2E,6E)-farnesyl diphosphate => 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77188", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20341", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.96", "l": "\"sn-glycerol-3-phosphate 1-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990663", "l": "dihydroorotate dehydrogenase (fumarate) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928619", "l": "PAK1 binds RAC1:GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030570", "l": "pectate lyase activity", "d": ["Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51906", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32984", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25744", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine => (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38774", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62502", "l": "AMP + H(+) + L-arginyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-arginyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27366", "l": "bromide + S-adenosyl-L-methionine => bromomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604387", "l": "p-4S-NICD4 binds YWHAZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71562", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O <=> 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51639", "l": "a quinone + H2O + selenite <=> a quinol + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.24", "l": "\"ribonuclease T1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.41", "l": "\"xylogalacturonan beta-1,3-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56747", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45330", "l": "7,8-dihydromonapterin => 7,8-dihydroneopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171122", "l": "LDL + LDLR => LDL:LDLR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39939", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28671", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.42", "l": "\"homomethionine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69070", "l": "A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide => AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177930", "l": "GAB1 phosphorylation by EGFR kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25770", "l": "3-carboxy-2-oxobutanoate + H(+) <=> 2-oxobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61636", "l": "ATP + CoA + isophthalate = AMP + diphosphate + isophthalyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.58", "l": "\"isophthalate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033975", "l": "(R)-2-haloacid dehalogenase activity", "d": ["Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856945", "l": "PP2A methylation by LCMT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602484", "l": "Activation of proMMP11 by FURIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37860", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA => 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.94", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71241", "l": "2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+) => 2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30436", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45003", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA <=> CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61974", "l": "1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989764", "l": "Expression of CYP1A1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201622", "l": "Caspase-mediated cleavage of gelsolin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38910", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170149", "l": "Translocation of active Cdc25C to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607751", "l": "TRAF6 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10679", "l": "(2R,3S)-3-isopropylmalate <=> 2-isopropylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73304", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) => H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14124", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73043", "l": "creatine(in) = creatine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985644", "l": "COL1A1 gene expression is stimulated by RUNX2 and RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50024", "l": "dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48419", "l": "a ganglioside GA2 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM2 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54417", "l": "5alpha-campestan-3-one + NADP(+) => campest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070405", "l": "ammonium ion binding", "d": ["Binding to ammonium ions (NH4+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67105", "l": "2-oxoglutarate + fumigatonoid C + O2 => CO2 + H2O + novofumigatonin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936378", "l": "Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43350", "l": "cholesteryl (9Z-octadecenoate)(out) => cholesteryl (9Z-octadecenoate)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65888", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102117", "l": "gibberellin A9 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine = gibberellin A9 methyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45926", "l": "4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA => 9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.2.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604703", "l": "RUNX1 binds NOTCH4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71280", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) => chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62048", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803719", "l": "TP53 binds ZNF385A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090566", "l": "protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717841", "l": "holo-FDPS dimer binds NBPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76575", "l": "4-deoxy-L-threo-hex-4-enopyranuronate = 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60851", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42135", "l": "isonocardicin C <=> nocardicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983061", "l": "TSLP binds CRLF2:IL7R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110215", "l": "Cleavage of uracil by UNG glycosylase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36601", "l": "NADH + sulfur => hydrogen sulfide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37273", "l": "ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate => ATP + H2O + L-alanyl-L-glutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71886", "l": "GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25244", "l": "(S)-2-ureidoglycine + H2O <=> (S)-ureidoglycolate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19236", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] <=> H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77608", "l": "Binding of A1CF to stem-looped RNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37966", "l": "galactitol + NAD(+) <=> D-galactose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168459", "l": "Lyn activates ERK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25028", "l": "H(+) + H2O + S-methyl-5'-thioadenosine <=> NH4(+) + S-methyl-5'-thioinosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805638", "l": "KAT6A acetylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905030", "l": "voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48078", "l": "4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde => a primary alcohol + N,N-dimethyl-4-nitrosoaniline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72609", "l": "(E)-sinapoyl-CoA + AMP + H(+) => (E)-sinapoyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30768", "l": "D-glucurono-3,6-lactone + H2O => D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821982", "l": "SRPK1 phosphorylates PRM1 in PRM1:dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56714", "l": "H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102466", "l": "beta-carotene 2,2'-beta-hydroxylase activity", "d": ["Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42059", "l": "13-cis-retinol + NAD(+) <=> 13-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050294", "l": "steroid sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32895", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.56", "l": "\"1,8-cineole 2-exo-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22320", "l": "2 alpha-D-glucose 1-phosphate + H2O = D-maltose + 2 phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.139", "l": "\"maltose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75716", "l": "CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632970", "l": "MSH6 variant:MSH2-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69106", "l": "H2O + kynurenate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34150", "l": "2-deoxy-L-scyllo-inosose + L-glutamine <=> 2-deoxy-scyllo-inosamine + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42852", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.3.1.244", "l": "\"2-methylbutanoate polyketide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14562", "l": "(E,E)-piperoyl-CoA + piperidine => CoA + H(+) + piperine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015126", "l": "canalicular bile acid transmembrane transporter activity", "d": ["The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167427", "l": "Opioid dissociates from MOR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70590", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) <=> acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62431", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211206", "l": "Translocation of DFF to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75751", "l": "(9Z)-octadecenoate + H2O = 10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187828", "l": "Translocation of p21 to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65948", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 = A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34860", "l": "3-oxocyclopentanecarbonitrile + 2 H2O => 3-oxocyclopentanecarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43037", "l": "L-cysteine => 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13201", "l": "glycine + L-arginine = guanidinoacetate + L-ornithine", "d": [], "t": []}, {"i": "EC:2.1.4.1", "l": "\"glycine amidinotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72560", "l": "estrone 3-sulfate(out) + pentanoate(in) => estrone 3-sulfate(in) + pentanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70819", "l": "L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76973", "l": "(9Z)-octadecenoate + 2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+) => 1-(9Z-octadecenoyl)-2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53275", "l": "5-dehydro-L-gluconate <=> keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102975", "l": "versiconal hemiacetal acetate reductase activity", "d": ["Catalysis of the reaction: versiconol acetate + NADP = versiconal hemiacetal acetate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67109", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693148", "l": "BCKDK phosphorylates BCKDH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757256", "l": "MCM3 binds MCM5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63337", "l": "alpha-D-xylose => beta-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71240", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH => 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27531", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3S,6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59668", "l": "D-cellohexaose + O2 = D-cellohexaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662986", "l": "MT2A binds copper (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102124", "l": "gibberellin A12 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H = 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45405", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate => 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41956", "l": "2',3'-cyclophospho-CMP + H2O = cytidine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938887", "l": "PML binds RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36063", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + kunzeaol", "d": [], "t": []}, {"i": "EC:4.2.3.143", "l": "\"kunzeaol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813740", "l": "GDE1 hydrolyzes GroPIns (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.79", "l": "\"3beta,22alpha-dihydroxysteroid 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75627", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O = ectocarpin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134953", "l": "DHX36 or DHX9 binds MyD88 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050071", "l": "phosphatidylglycerol lysyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28295", "l": "(2E,6E)-farnesyl diphosphate => (-)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.5", "l": "\"short-chain 2-methylacyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18708", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12203", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> CO2 + mugineate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50156", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.60", "l": "\"CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22851", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) <=> 3-oxooctanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50783", "l": "NADP(+) + octanal <=> (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69175", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] <=> (2E)-2-butenoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77738", "l": "2 H2O + ITP <=> 2 H(+) + IMP + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620456", "l": "sGC stimulators bind sGC:NO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68610", "l": "Formation of ORC(2-5) complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67507", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10773", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O => D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77371", "l": "[alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate = [alpha-N-acetylneuraminyl-(2->8)](n+1)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59887", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 <=> 4-chloro-L-lysine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61266", "l": "H2O2 + NH4(+) + pyruvate => H2O + L-alanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877192", "l": "RUNX1 binds FOXP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49060", "l": "a long-chain alkane + FMNH2 + O2 = a long chain fatty alcohol + FMN + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.28", "l": "\"long-chain alkane monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067667", "l": "IL6 binds IL6R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13935", "l": "all-trans-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43238", "l": "1,2-dihexadecanoyl-sn-glycerol + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102557", "l": "protopanaxadiol 6-hydroxylase activity", "d": ["Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ = protopanaxatriol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676229", "l": "WIPIs bind PI3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60248", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20274", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429699", "l": "CERT1-2 complex binds ceramide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019134", "l": "glucosamine-1-phosphate N-acetyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114553", "l": "Activation of conventional Protein Kinase C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29055", "l": "a ubiquinone + 2 H(+)(in) + H2 = a ubiquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70275", "l": "H2O + raffinose = D-galactose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160121", "l": "bis(monoacylglycero)phosphate synthase activity", "d": ["Catalysis of the reaction: 2 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48871", "l": "H2O + NADH <=> AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607737", "l": "BCL10 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31532", "l": "2-oxoglutarate + L-arginine + O2 => CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46946", "l": "H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH => (S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5099899", "l": "WNT5A binds FZD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033459", "l": "GAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340214", "l": "CYGB binds O2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005172", "l": "vascular endothelial growth factor receptor binding", "d": ["Binding to a vascular endothelial growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41357", "l": "bacteriochlorophyll a + 3 NADP(+) => geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:0016896", "l": "RNA exonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49055", "l": "asperlicin C + H(+) + NADH + O2 <=> asperlicin E + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56723", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64163", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide <=> ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45509", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol => all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9718020", "l": "PTGFR binds PTGFR agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422454", "l": "Polysialylation of NCAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72377", "l": "hydrogencarbonate(in) + iodide(out) => hydrogencarbonate(out) + iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47125", "l": "glycine + hexacosanoate => H2O + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40107", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22133", "l": "ATP + D-maltose(out) + H2O => ADP + D-maltose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836773", "l": "RSV ssRNA binds C-ter TLR7 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40227", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 = A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.36", "l": "\"desulfo-A47934 sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53432", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57415", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) <=> ATP + H(+) + L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28687", "l": "(S)-dihydroorotate + ubiquinone-8 = orotate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050565", "l": "aerobactin synthase activity", "d": ["Catalysis of the reaction: ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H+."], "t": []}, {"i": "RHEA:32167", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.39", "l": "\"aerobactin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49335", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18499", "l": "L-xylulose 5-phosphate => L-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164616", "l": "Biogenesis and assembly of the telomerase RNP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65689", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52796", "l": "2 H(+) + Ni-sirohydrochlorin = Ni(2+) + sirohydrochlorin", "d": [], "t": []}, {"i": "EC:4.99.1.11", "l": "\"sirohydrochlorin nickelchelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55150", "l": "a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH => a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44986", "l": "CoA + O-3-methylbutanoyl-(R)-carnitine => (R)-carnitine + 3-methylbutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0035613", "l": "RNA stem-loop binding", "d": ["Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362485", "l": "GHBP binds GH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49951", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14827", "l": "(S)-carvone + H(+) + NADH => (1R,5S)-carveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66259", "l": "ATP + H(+) + IC-asc-C7 <=> diphosphate + IC-asc-C7-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36890", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.201143870267188", "identifiers": [{"i": "GO:0034062", "l": "5'-3' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656267", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693783", "l": "NAALADases hydrolyse NAAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61383", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O <=> 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51183", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46824", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69854", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) <=> a uridine in mRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63977", "l": "A + dihydropyriculariol => AH2 + pyriculariol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827997", "l": "Expression of NANOG in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694338", "l": "nsp1-4 cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734353", "l": "GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793472", "l": "RIPK3 binds p-S9-PRKN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67155", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] <=> L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69267", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate <=> an isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433725", "l": "Interaction of Afadin with F-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788628", "l": "p-Y-STATs dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21243", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3782655", "l": "HDAC10 deacetylates histone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187608", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656244", "l": "DRD2 binds DA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59698", "l": "D-cellotetraonate + H(+) => D-cellotetraono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830356", "l": "Expression of LHX1 (LIM1) in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34988", "l": "(S)-lactate(in) => (S)-lactate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67760", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016762", "l": "xyloglucan:xyloglucosyl transferase activity", "d": ["Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879909", "l": "Activation of STAT5a/b by JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47001", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19844", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47209", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002134", "l": "UTP binding", "d": ["Binding to UTP, uridine 5'-triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77494", "l": "3,3-dimethylbutan-2-one + hydrogen cyanide <=> (2S)-2-hydroxy-2-methyl-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12075", "l": "an (S)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54432", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362549", "l": "Hh-Np traffics to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10148", "l": "blasticidin S + H(+) + H2O = deaminohydroxyblasticidin S + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.23", "l": "\"blasticidin-S deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60338", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65798", "l": "1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72095", "l": "Internal Methylation of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944246", "l": "Association of procollagen type XXI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003885", "l": "D-arabinono-1,4-lactone oxidase activity", "d": ["Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "57.022589458994794", "identifiers": [{"i": "GO:0016773", "l": "phosphotransferase activity, alcohol group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18166", "l": "biphenyl + H(+) + NADH + O2 => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102804", "l": "oripavine 6-O-demethylase activity", "d": ["Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 = morphinone + formaldehyde + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617927", "l": "FOXO4 binds ATXN3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56364", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 = carminomycin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61789", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan => AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199935", "l": "MSK1 activates CREB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18274", "l": "H2O + O2 + putrescine => 4-aminobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635915", "l": "ATF4 and CEBPB,CEBPG bind the ASNS gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464822", "l": "RDH12 reduces atRAL to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11668", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}, {"i": "EC:2.7.9.4", "l": "\"alpha-glucan, water dikinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12409", "l": "L-lysine + NAD(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47576", "l": "a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14085", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56049", "l": "daidzein + UDP-alpha-D-glucose => daidzein 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71829", "l": "arsenate(out) + H(+)(out) => arsenate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20656", "l": "23,24-dihydrocucurbitacin B + NAD(+) <=> cucurbitacin B + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45248", "l": "butanoate(out) = butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50123", "l": "taurine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.264", "l": "\"L-idonate 5-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66651", "l": "(2E,6E)-farnesyl diphosphate <=> african-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10509", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33478", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928614", "l": "EFNB:GRB4 binds GIT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46865", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110491", "l": "DRheb is inhibited by the TSC1/2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77081", "l": "H(+) + pre-flavunoidine => 2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + N,N-dimethyl-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14906", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate => 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13484", "l": "ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47189", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol => hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71123", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA = AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691421", "l": "BTK binds BTK inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878117", "l": "RUNX3 binds ZFHX3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48852", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57870", "l": "(E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate => (E)-4-coumaroyl-CoA + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43797", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19090", "l": "S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250220", "l": "Homodimerization of ERBB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21285", "l": "all-trans-retinol + NAD(+) => all-trans-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37678", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62806", "l": "desertorin A + 2 H2O + NADP(+) => 2 7-demethylsiderin + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15913", "l": "ATP + thiamine phosphate = ADP + thiamine diphosphate", "d": [], "t": []}, {"i": "EC:2.7.4.16", "l": "\"thiamine-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814831", "l": "TBC1D20 binds RAB1:GTP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18395", "l": "2-methyl-3-oxopropanoate + L-alanine => (R)-3-amino-2-methylpropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362427", "l": "Hh-Np binds GPC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47302", "l": "(2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603784", "l": "PEX19:class I PMP binds PEX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237129", "l": "Acireductone is created (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618328", "l": "ATAT acetylates microtubules (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52804", "l": "(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.164", "l": "\"(+)-eremophilene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985153", "l": "OASL binds DDX58 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72119", "l": "(R)-carnitine(in) + glycine betaine(out) = (R)-carnitine(out) + glycine betaine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.-", "l": "\"Acting on acid anhydrides; catalyzing transmembrane movement of substances\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.73", "l": "\"lipopolysaccharide glucosyltransferase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856945", "l": "PP2A methylation by LCMT1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53737", "l": "a 2-halobenzoate + H(+) + NADH + O2 => a halide anion + catechol + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36745", "l": "CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44398", "l": "1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36098", "l": "S-adenosyl-L-methionine + salicylate <=> methyl salicylate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030340", "l": "hyaluronate lyase activity", "d": ["Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23568", "l": "(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]", "d": [], "t": []}, {"i": "EC:5.3.3.14", "l": "\"trans-2-decenoyl-[acyl-carrier-protein] isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545253", "l": "Deacetylation of cohesin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656207", "l": "CR2 RAF1 mutants don't bind YWHAB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31610", "l": "rhodopin <=> all-trans-lycopene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57498", "l": "2-methyl-cis-aconitate + H2O => 2-methylcitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36488", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44788", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine = H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69945", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449978", "l": "IL7 binds IL7R:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.528207968973732", "identifiers": [{"i": "GO:0016877", "l": "ligase activity, forming carbon-sulfur bonds", "d": ["Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.2.-.-", "l": "\"Forming carbon-sulfur bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2299620", "l": "Collagen XI cross-links with collagen II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75150", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-cyatha-3,12-diene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047155", "l": "3-hydroxymethylcephem carbamoyltransferase activity", "d": ["Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013020", "l": "Activation of GIRK/Kir3 Channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.15.1", "l": "\"venom exonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784494", "l": "EKC complex threonylcarbamoylates A37 of tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71416", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) => 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32237", "l": "AMP + H(+) + NADPH + phosphate => (6S)-NADPHX + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17580", "l": "ADP-D-glycero-beta-D-manno-heptose <=> ADP-L-glycero-beta-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44005", "l": "3-methyl fatty acid + ATP + CoA => a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467466", "l": "ABCA4 mediates atRAL transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70260", "l": "AMP(out) + phosphate(in) => AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875816", "l": "STAT3 binds activated MET receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77219", "l": "a dolichyl beta-D-mannosyl phosphate + L-tryptophyl-[protein] = a dolichyl phosphate + C-alpha-D-mannosyl-L-tryptophyl-[protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170846", "l": "TGFBR2 recruits TGFBR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17887", "l": "acetylene + H2O => acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421320", "l": "BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050060", "l": "long-chain-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10786", "l": "CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2484822", "l": "Kinetochore assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204549", "l": "Caveolin-1 binds Basigin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800793", "l": "PIDD1 translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77002", "l": "H(+) + NAD(+) + reduced [4Fe-4S]/[3Fe-4S]-[ferredoxin] <=> NADH + oxidized [4Fe-4S]/[3Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61476", "l": "a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.299", "l": "\"sphingoid base N-stearoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11064", "l": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.11", "l": "\"fructose-bisphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50402", "l": "CoA + S-octanoyl-L-cysteinyl-[PqsC protein] => L-cysteinyl-[PqsC protein] + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75049", "l": "N(omega),N(omega)-dimethyl-L-arginine(in) => N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697423", "l": "Endocytosis of SARS-CoV-2 Virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12994", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912734", "l": "CBL:CRKL binds RAPGEF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374699", "l": "UNC5A binds NRAGE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59806", "l": "D-phenylalanine => L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654571", "l": "Activated FGFR1 binds FRS3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.4", "l": "\"minus-end-directed kinesin ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19676", "l": "1,2,3-trihydroxybenzene + O2 <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035244", "l": "protein-arginine C-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. This modification has been detected in anaerobic bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156682", "l": "PLK1 phosphorylates NUDC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54415", "l": "a 3-oxo-5beta-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047473", "l": "D-alanine [D-alanyl carrier protein] ligase activity", "d": ["Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340214", "l": "CYGB binds O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67924", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70644", "l": "D-proline(out) + H(+)(out) => D-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24119", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-linalool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625091", "l": "FOXO1,FOXO3 bind ABCA6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858489", "l": "ppDVL binds DAAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061891", "l": "calcium ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55678", "l": "(2S)-2-amino-4-deoxychorismate + H2O => chorismate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72949", "l": "acetate(in) + 2 Na(+)(in) => acetate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35989", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13956", "l": "a D-aminoacyl-tRNA + H2O <=> a D-alpha-amino acid + a tRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806974", "l": "MET dimers autophosphorylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50698", "l": "calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033444", "l": "AAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102355", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity", "d": ["Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70207", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) = sphinga-4E,14Z-dienine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050188", "l": "phosphoenolpyruvate mutase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49204", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624951", "l": "TNPO1 binds KIF17 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68883", "l": "ATP + H(+) + NADPH + salicylate <=> AMP + diphosphate + NADP(+) + salicylaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21596", "l": "L-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690873", "l": "ACO1 binds 4Fe-4S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40032", "l": "ent-copalyl diphosphate + H2O => diphosphate + ent-manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11071", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19782", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033506", "l": "TYSND1 cleaves AGPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032977", "l": "membrane insertase activity", "d": ["Binds transmembrane domain-containing proteins and mediates their integration into a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57216", "l": "dGTP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47779", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14961", "l": "H2O + S-formylglutathione = formate + glutathione + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.12", "l": "\"S-formylglutathione hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18081", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + pentalenene", "d": [], "t": []}, {"i": "EC:4.2.3.7", "l": "\"pentalenene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29351", "l": "Zn(2+)(in) = Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112395", "l": "Abortive termination of elongation after arrest (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68176", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 = CO2 + dainate A + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5099899", "l": "WNT5A binds FZD4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061654", "l": "NEDD8 conjugating enzyme activity", "d": ["Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue."], "t": []}, {"i": "EC:2.3.2.34", "l": "\"E2 NEDD8-conjugating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69669", "l": "beta-D-glucose + luteolin => H2O + luteolin 4'-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451309", "l": "Edited Kainate Receptor binds glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29645", "l": "alpha-D-glucose + D-maltohexaose => D-maltoheptaose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.20", "l": "\"prostamide/prostaglandin F2alpha synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043731", "l": "6-hydroxynicotinate 3-monooxygenase activity", "d": ["Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196417", "l": "Reduction of desmosterol to cholesterol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42941", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29526", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709179", "l": "DPP4 binds DPP4 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48869", "l": "H2O + NADH => AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0017040", "l": "N-acylsphingosine amidohydrolase activity", "d": ["Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29075", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 = CO2(out) + H(+)(out) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015417", "l": "ABC-type polyamine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12750", "l": "3,4,5-trihydroxybenzoate + H(+) => 1,2,3-trihydroxybenzene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.256", "l": "\"fluoren-9-ol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005153", "l": "interleukin-8 receptor binding", "d": ["Binding to an interleukin-8 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990882", "l": "CDK1 phosphorylates NUP98 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20083", "l": "hexanoate + methylamine => H2O + N-methylhexanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57344", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844447", "l": "NLRP1 senses MDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28038", "l": "[thioredoxin]-disulfide + dCDP + H2O = [thioredoxin]-dithiol + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432652", "l": "Nuclear CRY is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694733", "l": "Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602454", "l": "proMMP9 binds TIMP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928619", "l": "PAK1 binds RAC1:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202443", "l": "Oligomerization of CARMA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400459", "l": "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42705", "l": "hercynine + L-cysteine + O2 => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19730", "l": "acetoacetate + H(+) => acetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963915", "l": "1,25(OH)2D binds VDR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32323", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.86", "l": "\"ent-kaurene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66779", "l": "ATP + H2O + uroporphyrin III(in) <=> ADP + H(+) + phosphate + uroporphyrin III(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033432", "l": "CGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19764", "l": "FMN-N(5)-oxide + H(+) + NADH <=> FMN + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13760", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-desulfoglucotropeolin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47426", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA => (2E,9Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57209", "l": "glyoxal + L-cysteinyl-[protein] => S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16116", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) <=> 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031720", "l": "haptoglobin binding", "d": ["Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74252", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53505", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675947", "l": "TNFSF18 binds TNFRSF18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64149", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GalNAc-R + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950740", "l": "CANX dissociates from IL12A:EBI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814096", "l": "ARL1:GTP binds SCOC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061463", "l": "O-acetyl-ADP-ribose deacetylase activity", "d": ["Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202164", "l": "Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75560", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] => cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47251", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72671", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 = 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693478", "l": "HTR1A binds HTR1A agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6794346", "l": "NRXNs bind NLGNs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031924", "l": "vitamin B6 transmembrane transporter activity", "d": ["Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24206", "l": "phosphate + sulfoacetaldehyde => acetyl phosphate + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11860", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.13.2", "l": "\"protein-histidine tele-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43902", "l": "beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+) => dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.-.-", "l": "\"Acting on the CH-OH group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76259", "l": "H(+)(in) + taurine(in) = H(+)(out) + taurine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102587", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948027", "l": "RNASEs bind bacterial phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446322", "l": "PARVA associates with Paxillin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373716", "l": "DCC interacting NCK-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75959", "l": "(S)-scoulerine + 2-oxoglutarate + O2 = (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30078", "l": "CMP + H2O <=> cytosine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351876", "l": "Caspase-mediated cleavage of occludin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32476", "l": "glycine + 3 S-adenosyl-L-methionine => glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0061860", "l": "DNA clamp unloader activity", "d": ["Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12497", "l": "2 Fe(2+) + 4 H2O + O2 => 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76050", "l": "(S)-tetrahydropalmatine + S-adenosyl-L-methionine <=> (S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450466", "l": "AUF1:mRNA complex is destroyed (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0031784", "l": "melatonin receptor binding", "d": ["Binding to a melatonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62642", "l": "[mycoredoxin]-L-disulfide + an alcohol + H2O => [mycoredoxin]-L-dithiol + a hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38914", "l": "avenacoside B + H2O <=> 26-desgluco-avenacoside B + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602473", "l": "Autocatalytic activation of MMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047401", "l": "trithionate hydrolase activity", "d": ["Catalysis of the reaction: H2O + trithionate = H+ + sulfate + thiosulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62967", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669863", "l": "Masitinib-resistant KIT mutants do not bind masitinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195734", "l": "Neuraminidase (NA) synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070728", "l": "leucine binding", "d": ["Binding to 2-amino-4-methylpentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16340", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685607", "l": "Sialic acid binds SIGLEC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786789", "l": "FLT3LG dimer binds FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50058", "l": "ADP + glycocholate(out) + H(+) + phosphate => ATP + glycocholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68163", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209944", "l": "25(OH)D binds GC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.19", "l": "\"lycopene beta-cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627369", "l": "SEPT4 binds XIAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49136", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 = H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30706", "l": "H(+) + salicylate <=> CO2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853429", "l": "PHLDA1 binds AURKA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015087", "l": "cobalt ion transmembrane transporter activity", "d": ["Enables the transfer of cobalt (Co) ions from one side of a membrane to the other."], "t": []}, {"i": "RHEA:28578", "l": "Co(2+)(in) = Co(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9736953", "l": "FURIN translocates to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295622", "l": "SPRY2 binds CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005095", "l": "GTPase inhibitor activity", "d": ["Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73459", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47632", "l": "H2O + L-arginine + NAD(+) = 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24017", "l": "16-epivellosimine + acetyl-CoA => CoA + vinorine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253343", "l": "WWOX binds ERBB4s80 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676257", "l": "Formation of the SET1A complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9619376", "l": "CAMK1 binds calmodulin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195378", "l": "Homodimerization of VEGF proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836270", "l": "TFAP2A binds TFAP2C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37555", "l": "D-kanosamine 6-phosphate + H2O = kanosamine + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.92", "l": "\"kanosamine-6-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850777", "l": "SPINK6 binds KLK14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166387", "l": "The FA anion diffuses away laterally from UCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163539", "l": "perilipin:CGI-58 complex -> perilipin + CGI-58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31492", "l": "soyasaponin III + UDP-beta-L-rhamnose => H(+) + soyasaponin I + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42590", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53907", "l": "ATP + L-threonyl-[tau protein] <=> ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57246", "l": "dGTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785409", "l": "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008747", "l": "N-acetylneuraminate lyase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180020", "l": "membrane bending activity", "d": ["The activity of bending or deforming a membrane. This activity can occur by multiple mechanisms including the insertion amphipathic domains into one or both leaflets."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176452", "l": "Degradation of ubiquitinated SMAD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16631", "l": "acetyl-CoA + glyoxylate => (S)-malyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928631", "l": "GIT1 binds bPIX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23125", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) => CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16679", "l": "fluoroacetate + 2 H(+) + NADH => fluoroacetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74885", "l": "GUCYs converts GTP to cGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56012", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43643", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65128", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373747", "l": "Phosphorylation of nephrin by FYN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23321", "l": "D-tryptophan + malonyl-CoA => CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58503", "l": "glycine betaine + H(+) + NADH + O2 <=> glyoxylate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005130", "l": "granulocyte colony-stimulating factor receptor binding", "d": ["Binding to a granulocyte colony-stimulating factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38960", "l": "a 2,3-saturated acyl-CoA + O2 => a (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106302", "l": "arachidonic acid 8,9-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid."], "t": []}, {"i": "RHEA:64984", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41364", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421515", "l": "uroporphyrinogen III => coproporphyrinogen III + 4 CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69801", "l": "D-tryptophan + tRNA(Trp) => D-tryptophanyl-tRNA(Trp) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197958", "l": "FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514865", "l": "cGMP dissociates from CNG channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34184", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69152", "l": "spermine monoaldehyde = acrolein + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67657", "l": "2 Fe(III)-[cytochrome c] + NADPH => 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984606", "l": "Kinesin-5 is a homotetramer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30574", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34244", "l": "GTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin guanine dinucleotide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878056", "l": "RUNX1:CBFB binds EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22386", "l": "1D-myo-inositol hexakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608855", "l": "PRICKLE1 is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53853", "l": "glycocholate + NAD(+) => 7-oxo-glycodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25933", "l": "4-methylquinoline + A + H2O => 4-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851933", "l": "MET phosphorylates GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31421", "l": "(-)-beta-curcumene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786155", "l": "POLN binds ICL-DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67708", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55543", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] <=> 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70560", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61879", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52842", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP => UDP-alpha-D-glucose + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805638", "l": "KAT6A acetylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75449", "l": "(9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.98", "l": "\"4-hydroxy-3-polyprenylbenzoate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199154", "l": "CD200 binds to CD200R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50521", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68223", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol <=> (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109700", "l": "AKT2 binds PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111238", "l": "Formation of ADAR2  homodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008020", "l": "G protein-coupled photoreceptor activity", "d": ["Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334827", "l": "SUMO-CRABP2 binds atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451033", "l": "(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57952", "l": "H(+) + NADH + O2 + phenol = catechol + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.244", "l": "\"phenol 2-monooxygenase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818574", "l": "TASP1 cleaves KMT2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609738", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2C (GRIN2C) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419166", "l": "GEFs activate RhoA,B,C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681980", "l": "ATG12 binds ATG7 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50567", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41660", "l": "dihydrosanguinarine + NAD(+) = NADH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.435", "l": "\"L-fucose dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432381", "l": "PDP1 replaces VRI as binder to Clk and cry genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50681", "l": "H2O + N-terminal L-glutaminyl-[protein] => N-terminal L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631885", "l": "PRDX1 overoxidizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72924", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14330", "l": "2-oxoglutarate + O-phospho-L-serine => 3-phosphooxypyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62367", "l": "FMN-N(5)-peroxide + thymine <=> (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.349", "l": "\"toxoflavin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76035", "l": "(S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16105", "l": "a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57823", "l": "[phosphate](n) + ADP <=> [phosphate](n+1) + AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55540", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] = 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": [], "t": []}, {"i": "EC:1.18.6.2", "l": "\"vanadium-dependent nitrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73761", "l": "2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59215", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP <=> AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49561", "l": "D-sedoheptulose 7-phosphate => (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805740", "l": "SETD8 methylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67962", "l": "4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-amino-L-phenylalanine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110218", "l": "Cleavage of uracil by TDG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018747", "l": "RHOQ GEFs activate RHOQ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419334", "l": "Melatonin receptors can bind melatonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35201", "l": "(S,S)-tartrate(in) => (S,S)-tartrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196773", "l": "COASY phosphorylates DP-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32442", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877421", "l": "CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.295", "l": "\"2-methyl-6-phytyl-1,4-hydroquinone methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23949", "l": "4-hydroxybutanoate + NAD(+) => H(+) + NADH + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48025", "l": "1,2,3-tripropanoylglycerol + H2O => dipropanoylglycerol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16227", "l": "N-(6-aminohexanoyl)-6-aminohexanoate => 1,8-diazacyclotetradecane-2,9-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71602", "l": "2-oxoglutarate(out) + maleate(in) <=> 2-oxoglutarate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37778", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48908", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.800315015132711", "identifiers": [{"i": "GO:0016407", "l": "acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396009", "l": "STING binds c-di-GMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74059", "l": "PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75310", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) <=> D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63700", "l": "mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.314050959231352", "identifiers": [{"i": "GO:0016861", "l": "intramolecular oxidoreductase activity, interconverting aldoses and ketoses", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears."], "t": []}, {"i": "EC:5.3.1.-", "l": "\"Interconverting aldoses and ketoses\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28357", "l": "decanoyl-CoA + FAD + H(+) <=> (2E)-decenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76796", "l": "2-aminopropan-1-ol + H2O + NAD(+) => H(+) + hydroxyacetone + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72846", "l": "3'-dephospho-CoA(in) + ADP(out) <=> 3'-dephospho-CoA(out) + ADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60900", "l": "a cytidine in RNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24177", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31044", "l": "(S)-2-methyl-3-oxopropanoate + H2O + NAD(+) => 2 H(+) + methylmalonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43220", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.242", "l": "\"16S rRNA (guanine(1516)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32536", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O => 4-hydroxy-2-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2214351", "l": "PLK1 phosphorylates GORASP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22618", "l": "2 (2R)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27527", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21433", "l": "(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44613", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58387", "l": "NADP(+) + octan-1-ol <=> H(+) + NADPH + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55318", "l": "4 H(+) + 3 NADH + sulfite => 3 H2O + hydrogen sulfide + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034869", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240782", "l": "E2F1/2/3 stimulates EED transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607737", "l": "BCL10 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12516", "l": "(2E,6E)-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.23", "l": "\"germacrene-A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759186", "l": "AcK-NFE2L2- dependent NQO1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34721", "l": "(2E)-13-methyltetradecenal + phosphoethanolamine => 15-methylhexadecasphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730858", "l": "Autophosphorylation of BTK/ITK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24174", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5beta-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34282", "l": "di-trans,poly-cis-dolichol + NADP(+) <=> di-trans,cis-polyprenol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682377", "l": "LC3 de-lipidation by ATG4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42366", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46300", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102551", "l": "homogentisate geranylgeranyl transferase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + homogentisate + H+ = diphosphoric acid + 2-methyl-6-geranylgeranyl-1,4-benzoquinol + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607746", "l": "PKC-delta is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429497", "l": "SLP-76 stimulates PLC gamma 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14931", "l": "androst-4-ene-3,17-dione + H(+) + NADH => NAD(+) + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72631", "l": "Formation of the cap-binding eIF4F complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30569", "l": "5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate => 5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75172", "l": "Formation of RAD50:MRE11 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351894", "l": "Caspase mediated cleavage of BAP31 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50109", "l": "hexadecanoyl-CoA + taurine => CoA + H(+) + N-hexadecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33013", "l": "(+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209160", "l": "Phosphorylated HOP phosphorylates DOME (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52440", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47992", "l": "H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)", "d": [], "t": []}, {"i": "EC:7.1.1.1", "l": "\"proton-translocating NAD(P)(+) transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944220", "l": "Association of procollagen type XXIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951552", "l": "LTF:2xCO3(2-) dissociates from Carbocymycobactin:Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784765", "l": "p-Y705-STAT3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16164", "l": "2 Fe(III)-[leghemoglobin] + NADH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60763", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761828", "l": "NFE2L2 binds the PGD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41503", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15436", "l": "(2S)-naringenin + dimethylallyl diphosphate <=> diphosphate + sophoraflavanone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14687", "l": "AH2 + an aldehyde => A + a primary alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13896", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate <=> ADP + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59566", "l": "H(+) + N,N',N'',N'''-tetraacetylchitotetraonate => H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36135", "l": "(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70870", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) <=> L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52351", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.291", "l": "\"(R,S)-reticuline 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833248", "l": "NS1 (1C) binds to MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36993", "l": "alpha-D-ribose 1,5-bisphosphate + uracil => phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56660", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19721", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.1", "l": "\"stearoyl-CoA 9-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41808", "l": "(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60232", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109701", "l": "PDPK1 binds PIP3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35440", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine => archaetidylserine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54581", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP => a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39772", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55574", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716947", "l": "ESR1 binds ESR1 agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26061", "l": "methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+) => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939201", "l": "ESR dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682709", "l": "LGI4 binds ADAM22,23,11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954056", "l": "E2F6 binds TFDP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24336", "l": "a carboxylate + ATP + CoA = AMP + an acyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.29", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51532", "l": "H(+) + NADPH + O2 + urate = 5-hydroxyisourate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39613", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325540", "l": "Defective extracellular BTD does not hydrolyse BCTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34538", "l": "H(+) + hexadecanoyl-CoA + L-alanine <=> 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73600", "l": "CDP(in) + CTP(out) => CDP(out) + CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71352", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) => androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10234", "l": "5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate => 5,6-dihydrouridine 5'-monophosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012196", "l": "KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033414", "l": "UGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70999", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61830", "l": "H(+) + stigmasteryl 3-beta-D-glucoside + UDP => stigmasterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098618", "l": "selenomethionine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met)."], "t": []}, {"i": "REACT:R-HSA-2408546", "l": "tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770142", "l": "Formation of the Spliceosomal B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55221", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64306", "l": "1-phenylpropan-1-one + L-alanine => 1-phenylpropylamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59995", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate <=> (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32546", "l": "(2E)-geranyl diphosphate + H2O <=> 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27610", "l": "formate + H(+) = CO2 + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53078", "l": "5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18757", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = CO2 + cylindrospermopsin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66643", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + koraiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003945", "l": "N-acetyllactosamine synthase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835328", "l": "NPM binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237119", "l": "Acireductone is oxidized to MOB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671772", "l": "p-T38-PPP1R14A binds MLCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42141", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21504", "l": "acetoin + aldehydo-D-ribose 5-phosphate = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": [], "t": []}, {"i": "EC:2.2.1.4", "l": "\"acetoin--ribose-5-phosphate transaldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21915", "l": "CoA + H(+) + O2 + pyruvate <=> acetyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49171", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46421", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623427", "l": "IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017064", "l": "fatty acid amide hydrolase activity", "d": ["Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71742", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) <=> 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72120", "l": "(R)-carnitine(in) + glycine betaine(out) => (R)-carnitine(out) + glycine betaine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67345", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21745", "l": "S-adenosyl-L-methionine => 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19501", "l": "4-guanidinobutanoate + H2O = 4-aminobutanoate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43139", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47693", "l": "AH2 + neomycin C + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004709", "l": "MAP kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25282", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.17", "l": "\"squalene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50844", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25611", "l": "beta-D-allopyranose => beta-D-allofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54341", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38637", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44823", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32108", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine => H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23057", "l": "urea => cyanamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46266", "l": "a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20976", "l": "a primary nitroalkane + H2O + O2 = an aldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22519", "l": "ATP + taurocyamine <=> ADP + H(+) + N-phosphotaurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38198", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873917", "l": "Translocation of STAT1 dimer to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37597", "l": "1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035227", "l": "TXN2 binds CysS248-MPST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050558", "l": "maltose epimerase activity", "d": ["Catalysis of the reaction: alpha-maltose = beta-maltose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56040", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24569", "l": "a 6-phospho-beta-D-galactoside + H2O => an alcohol + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44827", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43335", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13236", "l": "guanosine + phosphate <=> alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.799193640989813", "identifiers": [{"i": "GO:0016701", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor."], "t": []}, {"i": "EC:1.13.-.-", "l": "\"Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20815", "l": "(3S)-citryl-CoA <=> acetyl-CoA + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26252", "l": "H(+) + levopimaradienol + NADPH + O2 <=> 2 H2O + levopimaradienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183055", "l": "Binding of CBL to EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428750", "l": "Gq activation by TP receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18087", "l": "coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine => coenzyme B + coenzyme M + methanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22762", "l": "CO2 + hnu + oxidized Cypridina luciferin => Cypridina luciferin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033845", "l": "hydroxymethylfurfural reductase (NADPH) activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32878", "l": "a 1-acyl-sn-glycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66403", "l": "ATP + glutathione(in) + glycocholate(in) + H2O <=> ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40411", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934446", "l": "Activated PKC phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44285", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA => 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75727", "l": "(10E,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021953", "l": "GAMT gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56131", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin <=> AH2 + diphosphate + flavuxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71018", "l": "H2O + N-methylputrescine + O2 <=> 4-methylaminobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24961", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 => [excited state blue fluorescent protein] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52044", "l": "mogrol + UDP-alpha-D-glucose = H(+) + mogroside IE + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.350", "l": "\"mogroside IE synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39726", "l": "a 1,2-diacyl-sn-glycerol(in) <=> a 1,2-diacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16649", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.102", "l": "\"N-methylcoclaurine 3'-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74733", "l": "7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53746", "l": "glycine + H(+) + tRNA(Ala) => glycyl-tRNA(Ala) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52370", "l": "adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805638", "l": "KAT6A acetylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61376", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032566", "l": "dGDP binding", "d": ["Binding to dGDP, deoxyguanosine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71010", "l": "L-phenylalanine(out) + L-tryptophan(in) <=> L-phenylalanine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54155", "l": "a uridine in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18889", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.15", "l": "\"alpha,alpha-trehalose-phosphate synthase (UDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22247", "l": "kaempferol + UDP-alpha-D-xylose <=> H(+) + kaempferol 3-O-beta-D-xyloside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047079", "l": "deoxyuridine 1'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047017", "l": "prostaglandin-F synthase activity", "d": ["Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25475", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-himachalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75238", "l": "TRAIL binds TRAIL receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16273", "l": "an N-acylsphing-4-enine + CDP-choline = a sphingomyelin + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.3", "l": "\"ceramide cholinephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295622", "l": "SPRY2 binds CBL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41057", "l": "1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55982", "l": "an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+) => a 1,2-saturated acyl-CoA + an acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10959", "l": "(E)-cinnamate + H(+) + NADPH + O2 <=> H2O + NADP(+) + trans-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018751", "l": "3,5-dichlorophenylcarboximide hydrolase activity", "d": ["Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43352", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62624", "l": "[glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.25", "l": "\"glutaredoxin-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40889", "l": "H(+) + octadecanoate + sn-glycerol 3-phosphocholine => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58843", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25551", "l": "(+)-copalyl diphosphate <=> abieta-8(14),12-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12861", "l": "guanosine + H(+) + H2O = NH4(+) + xanthosine", "d": [], "t": []}, {"i": "EC:3.5.4.15", "l": "\"guanosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37096", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373746", "l": "SEMA4D interacts with CD45 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102191", "l": "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) = 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53906", "l": "ADP + H(+) + O-phospho-L-threonyl-[tau protein] => ATP + L-threonyl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782943", "l": "UV-DDB ubiquitinates XPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168640", "l": "Ubiquitinated IkB is degraded (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13424", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate <=> an N-acylneuraminate 9-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41239", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]-acylsphin-4-enine + O2 = N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186785", "l": "PDGF-AA clevage by Furin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591086", "l": "SERPINA5 binds activated protein C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16267", "l": "5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.14.-", "l": "\"Protein-arginine kinases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63486", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein] => 2-oxoglutarate + L-prolyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54123", "l": "coelenterazine h + O2 <=> coelenterazine h dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186765", "l": "PLC-gamma binds to the active receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74377", "l": "H2O2(in) => H2O2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56441", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45804", "l": "ATP + hydroxylamine + L-glutamate = ADP + L-glutamine hydroxamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34408", "l": "3 ATP => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40601", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351936", "l": "Caspase-mediated cleavage of claspin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15186", "l": "L-arginine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48334", "l": "a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835358", "l": "p-TARBP2 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70817", "l": "H(+)(out) + L-histidine(out) + L-ornithine(in) => H(+)(in) + L-histidine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53155", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617446", "l": "HOXD1 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9005980", "l": "IL21 binds IL21R:JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10734", "l": "AMP + CO2 + diphosphate + firefly oxyluciferin + hnu => ATP + firefly D-luciferin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445143", "l": "RAB8A,10,13,14 hydrolyze GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047518", "l": "1-methyladenosine nucleosidase activity", "d": ["Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + ribofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16386", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 => CO2 + H2O + hydroquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168882", "l": "Association of NP into rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3159259", "l": "MMAA:MUT binds AdoCbl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23362", "l": "alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP => L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39855", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004561", "l": "alpha-N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444523", "l": "CXCR5 binds CXCL13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74905", "l": "(2E)-but-2-enoyl-AMP + diphosphate => (2E)-2-butenoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71258", "l": "3 Na(+)(out) + phosphate(out) <=> 3 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56619", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene <=> 1,2,4-trichlorobenzene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66108", "l": "2-oxobutanoate + L-cysteine = (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997237", "l": "SH2B proteins bind JAK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102193", "l": "protein-ribulosamine 3-kinase activity", "d": ["Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine = ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24305", "l": "glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] => CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50716", "l": "dimethyl sulfone + FMNH2 + O2 = FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32096", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831425", "l": "PAX2 binds the PLAC8 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27626", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate = beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68733", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68990", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050005", "l": "isohexenylglutaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636128", "l": "Translocation of SCP, Triplex (TRI) complex, CVC complex, and Accessory Proteins from the cytoplasm into the nucleous (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004477", "l": "methenyltetrahydrofolate cyclohydrolase activity", "d": ["Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048027", "l": "mRNA 5'-UTR binding", "d": ["Binding to an mRNA molecule at its 5' untranslated region."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56557", "l": "(2E,6E)-farnesyl diphosphate => delta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46200", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030767", "l": "3-hydroxyanthranilate 4-C-methyltransferase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419843", "l": "CALCA(83-119) binds CALCR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983696", "l": "The Immunoglobulin of the BCR binds antigen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69863", "l": "a uridine in mRNA + S-adenosyl-L-methionine = a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009485", "l": "IL34:CSF1 binds CSF1R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20379", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => androsterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22950", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => D-tagatofuranose 1,6-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021050", "l": "HSBP1 oligomer binds ESRs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983266", "l": "Kinesins bind microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40545", "l": "H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16370", "l": "(R)-lactate + NAD(+) => H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647632", "l": "CASP3 cleaves GSDME (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169406", "l": "ISGylation of host proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69387", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) <=> (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63998", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24688", "l": "formate + methanofuran => H2O + N-formylmethanofuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15208", "l": "a dolichyl diphosphooligosaccharide + H2O <=> a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24849", "l": "3-dehydroshikimate => 3,4-dihydroxybenzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49842", "l": "(-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (-)-dehydrodiconiferyl acid + 2 a quinone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42643", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine <=> a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20456", "l": "scopoletin + UDP-alpha-D-glucose <=> H(+) + scopolin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170991", "l": "SRC-1 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670014", "l": "Factor VIIIa dissociates  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376119", "l": "Interaction of Bnip-2 with Cdc42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55245", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299359", "l": "Activation of TALK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047753", "l": "choline-sulfatase activity", "d": ["Catalysis of the reaction: choline sulfate + H2O = choline + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54058", "l": "(2E,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814778", "l": "GDPD3 hydrolyzes LysoPtdCho (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69685", "l": "CHEK2 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49946", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624131", "l": "UNC119B binds myristoylated proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52764", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O = (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30387", "l": "GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58744", "l": "H2O + N(7)-methyl-GTP = diphosphate + H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034632", "l": "retinol transmembrane transporter activity", "d": ["Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31687", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004693", "l": "cyclin-dependent protein serine/threonine kinase activity", "d": ["Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202692", "l": "PIP3 binds to RhoA and activates it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24142", "l": "2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008263", "l": "pyrimidine-specific mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38193", "l": "17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52353", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21927", "l": "3-dehydro-L-gulonate + NAD(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428625", "l": "Vesicular inhibitory amino acid transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68780", "l": "(2Z,6Z)-farnesyl diphosphate = alpha-humulene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15805", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.3.3", "l": "\"dethiobiotin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24998", "l": "H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351876", "l": "Caspase-mediated cleavage of occludin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043857", "l": "N-acetylornithine carbamoyltransferase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35343", "l": "3-hydroxydocosanoyl-CoA + NADP(+) = 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75142", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 <=> asukamycin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28283", "l": "(S)-beta-bisabolene => (S)-beta-macrocarpene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74868", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) => (E)-caffeoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51710", "l": "H(+) + keto-D-tagatose + NADH => D-altritol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0140318", "l": "protein transporter activity", "d": ["Directly binding to a specific protein and delivering it to a specific cellular location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68745", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112379", "l": "Recruitment of elongation factors to form elongation complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38604", "l": "NADP(+) => 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72674", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75775", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O = (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18425", "l": "L-quinate + NADP(+) = 3-dehydroquinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46738", "l": "a monoacylglycerol + phosphate => H2O + monoacyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.214", "l": "\"2-dehydropantolactone reductase (Si-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72660", "l": "NADPH + O2 + quinolin-8-ol => 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877414", "l": "FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75136", "l": "NADP(+) + neopine => H(+) + NADPH + neopinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15214", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA => CoA + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070137", "l": "ubiquitin-like protein-specific endopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62349", "l": "H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30250", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 <=> O2 + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21299", "l": "D-galactose + NAD(+) <=> D-galactono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75862", "l": "Fall Back to Closed Pre-initiation Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392195", "l": "Gi activation by P2Y purinoceptor 12 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34119", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.206", "l": "\"3,5,7-trioxododecanoyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614271", "l": "Autocleavage of ADGRG6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198983", "l": "NKG2D homodimer interacting with ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168376", "l": "STIM1 oligomerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15340", "l": "H2O + phenylglyoxylyl-CoA <=> CoA + H(+) + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042329", "l": "structural constituent of collagen and cuticulin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41090", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12753", "l": "glycerol + NADP(+) = dihydroxyacetone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.156", "l": "\"glycerol 2-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30195", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11465", "l": "2 glutathione + L,L-homocystine => glutathione disulfide + 2 L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411402", "l": "Activation of NLK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31562", "l": "L-galactose + NAD(+) <=> H(+) + L-galactono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74711", "l": "Phosphorylation of IRS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60996", "l": "H2O + L-leucine + O2 = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004937", "l": "alpha1-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58823", "l": "H(+) + malonate + Na(+)(in) <=> acetate + CO2 + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11751", "l": "fluoroacetaldehyde + L-threonine <=> 4-fluoro-L-threonine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42647", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] <=> diphosphate + holo-[malonate decarboxylase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47909", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851933", "l": "MET phosphorylates GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0003995", "l": "acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653974", "l": "Ragulator binds Rag dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21297", "l": "D-galactose + NAD(+) => D-galactono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047197", "l": "triglyceride-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59501", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655244", "l": "Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373729", "l": "Neurofascin binds Ankyrin-G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62489", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770119", "l": "Formation of the Spliceosomal E complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61863", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 <=> epoxybetaenone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74583", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] = N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34778", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) <=> a 3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000995", "l": "RNA polymerase III general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76556", "l": "ergosterol + L-aspartyl-tRNA(Asp) => 1-(ergostan-3beta-yl)-L-aspartate + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56254", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193650", "l": "p75NTR binds to NADE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59412", "l": "2-oxosuccinamate + H2O = NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50043", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73537", "l": "CDP(in) + UTP(out) => CDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61247", "l": "H2O + L-tryptophan + O2 <=> H2O2 + indole-3-pyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36517", "l": "3-oxohexacosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73832", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141409", "l": "Mad1 binds kinetochore (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25651", "l": "(6R)-isopiperitenone + H(+) + NADPH => (2R,5R)-isopulegone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015042", "l": "trypanothione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73627", "l": "CTP(out) + GMP(in) = CTP(in) + GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57497", "l": "2-methylcitrate => 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53964", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin = gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": [], "t": []}, {"i": "EC:2.3.2.19", "l": "\"ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74559", "l": "aldosterone = aldosterone hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690196", "l": "USP8 deubiquitinates RNF128 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483174", "l": "PE is methylated to PC by PEMT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50903", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O <=> (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51684", "l": "(2E,6E)-farnesyl phosphate + CTP = (2E,6E)-farnesyl diphosphate + CDP", "d": [], "t": []}, {"i": "EC:2.7.4.32", "l": "\"farnesyl phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70450", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64476", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11985", "l": "AH2 + O2 + progesterone => A + H2O + testosterone acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74703", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] = 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416683", "l": "SEMA3E binds to PLXND1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64864", "l": "ITP + oxaloacetate = CO2 + IDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684836", "l": "CLEC1B dimer binds PDPN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15387", "l": "3-cyano-L-alanine + H2O => L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59607", "l": "H2O + O2 + spermidine <=> H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047983", "l": "homoglutathione synthase activity", "d": ["Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51943", "l": "(1E,2S)-2-methylbutanal oxime <=> (1Z,2S)-2-methylbutanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69694", "l": "a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine <=> a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28926", "l": "H(+)(in) + L-phenylalanine(in) <=> H(+)(out) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031736", "l": "CCR11 chemokine receptor binding", "d": ["Binding to a CCR11 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013435", "l": "RHOD auto-activates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54938", "l": "decanoyl-[ACP] + NAD(+) => (2E)-decenoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66806", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate => ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14218", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050226", "l": "psychosine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174157", "l": "Degradation of multiubiquitinated Cyclin B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32180", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) => dipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20346", "l": "[thioredoxin]-dithiol + NADP(+) => [thioredoxin]-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75344", "l": "adenosine(in) => adenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate => diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60478", "l": "3',3',3'-cAAG + 3 diphosphate => 2 ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29761", "l": "octanoate(out) => octanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20372", "l": "betaine aldehyde + H2O + O2 <=> glycine betaine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70300", "l": "H2O + L-dehydroascorbate => 2,3-dioxo-L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50383", "l": "3 H(+) + 3 malonyl-CoA <=> 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042973", "l": "glucan endo-1,3-beta-D-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33652", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA => (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429529", "l": "Thrombin binding to GP1b:IX:V (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48532", "l": "a ganglioside GQ1c (d18:1(4E)) + H2O = a ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56572", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = a globoside Gb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67056", "l": "chermesin D + S-adenosyl-L-methionine = chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17607", "l": "ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate => ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218806", "l": "FYN autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111956", "l": "Calmodulin activates Cam-PDE 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60509", "l": "a guanosine in mRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23027", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate <=> [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43104", "l": "AH2 + an N-acyleicosasphinganine + O2 = A + an N-acyleicosasphing-4-enine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43688", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate = L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047583", "l": "4-methyloxaloacetate esterase activity", "d": ["Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H2O = H+ + methanol + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31448", "l": "6-amino-2-oxohexanoate + H2O2 => 5-aminopentanoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67035", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29889", "l": "ADP + H(+) + L-lysine(in) + phosphate => ATP + H2O + L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37421", "l": "1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21567", "l": "acetyl-CoA + an acyl-CoA <=> a 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005334", "l": "norepinephrine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36347", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": [], "t": []}, {"i": "EC:4.1.3.44", "l": "\"tRNA 4-demethylwyosine synthase (AdoMet-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60626", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77638", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20757", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate => 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013004", "l": "RHOA binds effectors at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28494", "l": "a menaquinone + dimethyl sulfide + H2O = a menaquinol + dimethyl sulfoxide", "d": [], "t": []}, {"i": "EC:1.8.5.3", "l": "\"respiratory dimethylsulfoxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12320", "l": "17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.73", "l": "\"1,2-dihydrovomilenine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47255", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24021", "l": "2-(N(omega)-L-arginino)succinate => fumarate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40265", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32821", "l": "chromate(out) => chromate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51102", "l": "16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400023", "l": "Gq alpha activates Phospholipase C beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032562", "l": "dAMP binding", "d": ["Binding to dAMP, deoxyadenosine monophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42131", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13440", "l": "(E)-cinnamate + UDP-alpha-D-glucose <=> 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67023", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855155", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34961", "l": "(R)-carnitine(out) => (R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55816", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15952", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028820", "l": "Formation of VAF (virus-activated factor) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25323", "l": "H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine => N-methylethanolamine phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63134", "l": "cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione => apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27558", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46609", "l": "ATP + L-threonyl-[protein] => ADP + H(+) + O-phospho-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033723", "l": "fluoroacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21939", "l": "carbamoyl phosphate + putrescine <=> H(+) + N-carbamoylputrescine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38587", "l": "UDP-alpha-D-glucose + vancomycin aglycone = devancoaminyl-vancomycin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.310", "l": "\"vancomycin aglycone glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30536", "l": "biotinate sulfoxide + H(+) + NADPH => biotin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66101", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => H2O + kynurenate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70437", "l": "a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380508", "l": "Translocation of NuMA to the centrosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24539", "l": "L-tryptophan + O2 <=> N-formyl-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35052", "l": "N,N'-diacetylchitobiose(out) => N,N'-diacetylchitobiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76442", "l": "19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11898", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADH => 7alpha-hydroxycholesterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047244", "l": "N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39509", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0017022", "l": "myosin binding", "d": ["Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950778", "l": "p-Y693-STAT4 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72954", "l": "butanoate(out) + 2 Na(+)(out) <=> butanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39188", "l": "(3R)-hydroxydocosanoyl-CoA => (2E)-docosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176175", "l": "Stalling of DNA replication fork and RPA binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818682", "l": "MEN1 binds MLL2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56608", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O = L-serine + tetrahydrosulfopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58659", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32733", "l": "a fatty acid + a monoacylglycerol + H(+) => a diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38820", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602484", "l": "Activation of proMMP11 by FURIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050660", "l": "flavin adenine dinucleotide binding", "d": ["Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021944", "l": "MECP2 binds RBFOX1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58395", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55869", "l": "(S)-lactate + O2 => H2O2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43796", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65029", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] => (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74047", "l": "L-alanine(in) + L-valine(out) = L-alanine(out) + L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75812", "l": "acetoacetate(out) + Na(+)(out) => acetoacetate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43593", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15603", "l": "(E)-cinnamate + (R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + (R)-3-phenyllactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.24", "l": "\"diphosphoinositol-pentakisphosphate 1-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43115", "l": "(R)-mandelate + NAD(+) <=> H(+) + NADH + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018472", "l": "1-hydroxy-2-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21430", "l": "H(+) + pyruvate + sulfite => (2R)-3-sulfolactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805285", "l": "PLK3 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371435", "l": "Constitutive phosphorylation by GSK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46229", "l": "apo-[peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24700", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655301", "l": "Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031781", "l": "type 3 melanocortin receptor binding", "d": ["Binding to a type 3 melanocortin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68718", "l": "diphosphate + germacrene D => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46186", "l": "3-methylbutanoyl-CoA + AMP + diphosphate => 3-methylbutanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14447", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37647", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63155", "l": "an N-fatty acyl-taurine + H2O <=> a fatty acid + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034323", "l": "O-butanoyltransferase activity", "d": ["Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008656", "l": "cysteine-type endopeptidase activator activity involved in apoptotic process", "d": ["Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37515", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592316", "l": "Initial activation of proMMP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938887", "l": "PML binds RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74031", "l": "L-alanine(in) + L-cysteine(out) = L-alanine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65202", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O => S-(acetaldehyde)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196753", "l": "2xPPCS ligates PPanK with Cys (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783681", "l": "LIF binds LIFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28985", "l": "nitrite(out) => nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46283", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38626", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70436", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 => a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69943", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624951", "l": "TNPO1 binds KIF17 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13929", "l": "agmatine + H2O = putrescine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.11", "l": "\"agmatinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20107", "l": "AMP + beta-D-fructose 1,6-bisphosphate + H(+) => ADP + beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48765", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) => 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70995", "l": "L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40609", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60138", "l": "a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976734", "l": "Amyloid fibrils have additional components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68124", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] = a triacylglycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67530", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine => (6Z)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46660", "l": "H(+) + NADPH + progesterone = 5beta-pregnan-3,20-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19739", "l": "4-aminobutanoate + L-glutamate => 4-(gamma-L-glutamylamino)butanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70425", "l": "a carboxylate + CoA + H(+) => an acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40793", "l": "CoA + H(+) + hexacosanoate => H2O + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103043", "l": "5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = H+ + alpha-D-ribose 1,5-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.65", "l": "\"thermomycolin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55920", "l": "[cis-1,4-isoprene](n) + O2 = (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": [], "t": []}, {"i": "EC:1.13.11.85", "l": "\"exo-cleaving rubber dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62718", "l": "stemphyloxin II => stemphyloxin I", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928645", "l": "EPHB:NMDAR binds TIAM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53855", "l": "glycocholate + NAD(+) <=> 7-oxo-glycodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48482", "l": "1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73109", "l": "apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => acacetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634861", "l": "NPAS4 binds ARNT2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140035", "l": "ubiquitination-like modification-dependent protein binding", "d": ["Binding to a protein upon modification by a ubiquitin-like protein of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785594", "l": "FANCD2 binds FANCI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49628", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010276", "l": "phytol kinase activity", "d": ["Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67359", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA <=> (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74429", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832169", "l": "NS1 (1C) localizes to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48262", "l": "a ganglioside GD1a + CMP + H(+) => a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798004", "l": "TP53 stimulates BNIP3L expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9822539", "l": "VWF multimer binds to collagen type I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37841", "l": "1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72793", "l": "bilirubin-glucuronoside(in) => bilirubin-glucuronoside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20993", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine => 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74755", "l": "kaempferide + S-adenosyl-L-methionine = 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187506", "l": "Translocation of p27 to the nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0010461", "l": "light-activated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of a monoatomic ion by a channel that opens in response to a light stimulus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417908", "l": "P2RY1 binds ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004505", "l": "phenylalanine 4-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380227", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702618", "l": "quizartinib-resistant FLT3 mutants don't bind quizartinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64361", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58889", "l": "4-aminobenzoate + AH2 + 2 O2 => 4-nitrobenzoate + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21368", "l": "H2O + O2 + urate = 5-hydroxyisourate + H2O2", "d": [], "t": []}, {"i": "EC:1.7.3.3", "l": "\"factor independent urate hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351208", "l": "Spermidine  => N-acetylated spermidine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40473", "l": "2-methyl-(2E)-pentadecenoyl-CoA + H2O2 => (2S)-methylpentadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72991", "l": "2 Na(+)(out) + scyllo-inositol(out) = 2 Na(+)(in) + scyllo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73833", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0060229", "l": "lipase activator activity", "d": ["Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50799", "l": "glutathione + prostaglandin A2 <=> prostaglandin A2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22309", "l": "O2 + xylitol => D-xylose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61192", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445448", "l": "HHIP binds Hedgehog (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58625", "l": "N-dodecanoyl-(2S)-hydroxyglycine => dodecanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37764", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-178208", "l": "SMAD7 binds to SMURF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37770", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030292", "l": "protein tyrosine kinase inhibitor activity", "d": ["Stops, prevents or reduces the activity of a protein tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9604328", "l": "AKT1 phosphorylates NOTCH4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33113", "l": "beta-copaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50326", "l": "1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11400", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin = 4'-O-demethylsordarin + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.353", "l": "\"sordaricin 6-deoxyaltrosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18813", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": [], "t": []}, {"i": "EC:5.3.3.10", "l": "\"5-carboxymethyl-2-hydroxymuconate Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61725", "l": "a D-glucoside + NAD(+) => a 3-dehydro-D-glucoside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53234", "l": "(24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944247", "l": "Association of procollagen type VI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106141", "l": "flavin prenyltransferase activity", "d": ["Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64496", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] = 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21736", "l": "(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53981", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47141", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43531", "l": "L-serine + NAD(+) <=> 2-aminomalonate semialdehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67542", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine => (9Z)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051059", "l": "NF-kappaB binding", "d": ["Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41525", "l": "5 H(+) + 5 malonyl-CoA => 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202947", "l": "Caspase mediated cleavage of APC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39284", "l": "a long-chain fatty acid(out) => a long-chain fatty acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203130", "l": "OLR1 binds to oxidized LDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72998", "l": "L-fucose(out) + 2 Na(+)(out) <=> L-fucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944262", "l": "Association of procollagen type X (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46927", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.42", "l": "\"atrolysin C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0043110", "l": "rDNA spacer replication fork barrier binding", "d": ["Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112430", "l": "Formation of P-TEFb complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37696", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA => 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13406", "l": "4-coumaroyl-CoA + agmatine => CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028820", "l": "Formation of VAF (virus-activated factor) complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211206", "l": "Translocation of DFF to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73935", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] = desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631885", "l": "PRDX1 overoxidizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008465", "l": "glycerate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41880", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69892", "l": "Na(+)(out) + thymidine(out) => Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27299", "l": "2-formylbenzoate + H2O + NAD(+) => 2 H(+) + NADH + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17740", "l": "NADP(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70744", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26378", "l": "GTP => cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77286", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22250", "l": "7,8-dihydroxykynurenate + H(+) + NADH => 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40275", "l": "hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851018", "l": "BTN2A1 binds DC-SIGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75550", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH <=> (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685156", "l": "ATR phosphorylates RPA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67699", "l": "H2O + hexadecanedioyl-CoA <=> CoA + H(+) + hexadecanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46689", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A => 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60307", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052678", "l": "levopimaradiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1264832", "l": "JAK1 binds IL7R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77234", "l": "cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + H2O <=> (S)-2-hydroxypropylphosphonate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380586", "l": "loading of Serotonin in synaptic vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944240", "l": "Association of procollagen type III (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49580", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}, {"i": "EC:4.6.1.17", "l": "\"cyclic pyranopterin monophosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47659", "l": "acetyl-CoA + L-methionine sulfone <=> CoA + H(+) + N-acetyl-L-methionine sulfone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50251", "l": "ATP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32851", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61554", "l": "gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74116", "l": "an anthocyanidin + UDP-alpha-D-galactose => an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24370", "l": "L-proline + NH4(+) => L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034783", "l": "pivalate-CoA ligase activity", "d": ["Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113429", "l": "Elongating transcript encounters a lesion in the template (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42981", "l": "L-tyrosine => 2-aminoprop-2-enoate + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965450", "l": "DAAM1 recruits PFN1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38231", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033520", "l": "TYSND1 cleaves TYSND1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028598", "l": "Phosphorylation of YAP by LATS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665280", "l": "ERBB2 KD mutants do not bind osimertinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56923", "l": "a medium chain fatty acid + ATP + H(+) <=> a medium-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73852", "l": "27-hydroxywithanone + UDP-alpha-D-glucose => H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299359", "l": "Activation of TALK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021480", "l": "NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36264", "l": "hydroxyurea + O-acetyl-L-serine => acetate + H(+) + O-ureido-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56079", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008966", "l": "phosphoglucosamine mutase activity", "d": ["Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61032", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine = 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781897", "l": "USP11 deubiquitinates NFKBIA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59502", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69224", "l": "a (Z)-alkenyl glucosinolate + H2O = a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76438", "l": "(2S,9S)-annullatin H + 2 A <=> (2S,9S)-annullatin D + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42630", "l": "5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(747) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50468", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700171", "l": "Active ALK phosphorylates PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50886", "l": "(9Z-octadecenoyl)-glycerol + phosphate => (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66205", "l": "heptanoyl-CoA + O2 => (2E)-heptenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530445", "l": "CD59 inhibits MAC formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40511", "l": "(2S)-3-sulfopropanediol + NAD(+) = (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.373", "l": "\"sulfolactaldehyde 3-reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453183", "l": "p-Y348-SYK dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955794", "l": "PGP:Mg2+ dimer hydrolyses 3PG to glycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390909", "l": "HRH2 binds hist (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534096", "l": "METAP1/2 demethylates GNAT1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53267", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59985", "l": "an N(2)-acyl-L-glutamine + H2O => a carboxylate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57181", "l": "L-lysyl-[protein] + methylglyoxal => N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29289", "l": "2 H(+)(out) + L-aspartate(out) => 2 H(+)(in) + L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70982", "l": "Fumarate + H2O <=> (S)-Malate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42267", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA <=> 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42344", "l": "H(+) + NADH + O2 + p-cumate = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.25", "l": "\"p-cumate 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708457", "l": "HM13 cleaves HMOX1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39230", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH <=> NADP(+) + octacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156910", "l": "Formation of eEF1B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27431", "l": "a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804100", "l": "HMGB1 binds LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63990", "l": "2-thiocytidine 5'-phosphate + ADP + H(+) => 2-thiocytidine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6802973", "l": "PLK3 phosphorylates CDC25C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814409", "l": "CK2 phosphorylates PDCL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-532549", "l": "MPI isomerises Fru6P to Man6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46600", "l": "[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41019", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24393", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate => dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222662", "l": "Nitric oxide enters the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40585", "l": "CoA + H(+) + hexanedioate => H2O + hexanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9008043", "l": "MAPK8 phosphorylation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606789", "l": "ARSB hydrolyses DS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24632", "l": "2 H2O + 3 NADP(+) + NH4(+) = 5 H(+) + 3 NADPH + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665748", "l": "FMNL2 binds RHOC:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74818", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050011", "l": "itaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76143", "l": "picrinine + S-adenosyl-L-methionine = ervincine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:1990239", "l": "steroid hormone binding", "d": ["Binding to a steroid hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.48", "l": "\"uridine/cytidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23082", "l": "2-dehydro-3-deoxy-L-rhamnonate + H2O => L-rhamnonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791092", "l": "Expression of DCTN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29263", "l": "L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869568", "l": "NPM1 binds TFAP2A homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870461", "l": "RABGGTA and RABGGTB bind (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53223", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983142", "l": "Formation of peptide loading complex (PLC) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43870", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173636", "l": "Formation of classic pathway C5 convertase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141423", "l": "Binding of the MCC complex to the APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265456", "l": "NPC1L1 binds ezetimibe (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53332", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71989", "l": "diphosphate + fusoxypene C => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051746", "l": "thalianol synthase activity", "d": ["Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25586", "l": "beta-L-rhamnose => alpha-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74795", "l": "N-methyl-(R)-salsolinol(in) = N-methyl-(R)-salsolinol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66797", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77094", "l": "Formation of cap binding complex (CBC) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70548", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46719", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54524", "l": "acetoacetate + H(+) + methylglyoxal = 3-hydroxyhexane-2,5-dione + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29089", "l": "menaquinol-8 + oxaloacetate => (S)-malate + menaquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14012", "l": "2 dimethylallyl diphosphate <=> (R,R)-chrysanthemyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61836", "l": "ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102421", "l": "curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose = curcumin 4'-O-beta-D-gentiotrioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621371", "l": "CLEC4C binds HIV and HCV glycoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809254", "l": "MTMR8 binds MTMR9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74726", "l": "Dissociation of insulin from insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927959", "l": "SUMOylation of CREBBP with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102331", "l": "heptadecanoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191636", "l": "Phosphorylation of Cx43 by c-src (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70093", "l": "hydroxyclavatol ethyl ether => ethanol + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48861", "l": "18-HEPE + O2 => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22687", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 <=> (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71720", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) => H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196417", "l": "Reduction of desmosterol to cholesterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69791", "l": "D-phenylalanyl-tRNA(Phe) + H2O = D-phenylalanine + H(+) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390930", "l": "5-HT2 receptor can bind serotonin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28533", "l": "H2O + XMP <=> phosphate + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.247", "l": "\"stachydrine N-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37761", "l": "1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45017", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine => L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451900", "l": "IL2RB binds JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670189", "l": "F8 variant does not bind the cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16068", "l": "2-oxoglutarate + O2 + phytanoyl-CoA <=> 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351871", "l": "Caspase-mediated cleavage of Z0-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29682", "l": "formate(in) <=> formate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45022", "l": "H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine => L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672158", "l": "GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944223", "l": "Association of procollagen type V (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53867", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64053", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine => CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35611", "l": "menadiol + 2 O2 = 2 H(+) + menadione + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17006", "l": "ATP + D-glucuronate => 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50090", "l": "21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42830", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11364", "l": "ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": [], "t": []}, {"i": "EC:2.7.9.2", "l": "\"pyruvate, water dikinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24387", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine <=> AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110311", "l": "POLZ extends translesion synthesis (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341294", "l": "Superoxide reduces cytochrome c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213464", "l": "RIPK1 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13042", "l": "L-dopachrome => 5,6-dihydroxyindole-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111915", "l": "CAMK4 autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34658", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082356", "l": "HSF1-mediated gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:0004634", "l": "phosphopyruvate hydratase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33258", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine <=> H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55311", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61348", "l": "ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69880", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] => castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426032", "l": "DAG is metabolized by DAGL to 2-AG (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15017", "l": "a phosphate monoester + H2O = an alcohol + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032402", "l": "Activated NTRK2 binds FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40996", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42241", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16553", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] = H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73130", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190541", "l": "Association of Cx43 with TJP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334099", "l": "UHRF1 binds chromatin with hemimethylated cytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38748", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426530", "l": "Laminins:Nidogens binds HSPG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12549", "l": "2-cis,4-trans-xanthoxin + NAD(+) => 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030629", "l": "U6 snRNA 3'-end binding", "d": ["Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11470", "l": "3-methyl-2-oxobutanoate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32079", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.929890650779797", "identifiers": [{"i": "GO:0060090", "l": "molecular adaptor activity", "d": ["The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54491", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686587", "l": "ABL1 phosphorylates RAD52 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28237", "l": "L-glutamate 5-semialdehyde <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35669", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031517", "l": "red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538891", "l": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322971", "l": "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.-", "l": "\"With dinitrogen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.-.-.-", "l": "\"Hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62676", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide = 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464803", "l": "RDH8 reduces atRAL to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759502", "l": "CDH11 nascent mRNA is spliced into the variant splicing isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671737", "l": "p-T774-PKN1 binds CDC25C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32789", "l": "ADP + H(+) + L-ectoine(in) + phosphate => ATP + H2O + L-ectoine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102447", "l": "rhamnetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432164", "l": "Ca2+ influx into the post-synaptic cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16395", "l": "H(+) + juvenile hormone II carboxylate + methanol => H2O + juvenile hormone II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39370", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102761", "l": "eriodictyol 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + homoeriodictyol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733973", "l": "Bile salts bind FABP6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73948", "l": "(2E)-geranyl diphosphate => (4E,6E)-allo-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12374", "l": "4-oxohex-2-enedioate + H(+) => 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034528", "l": "2-carboxy-2-hydroxy-8-carboxychromene isomerase activity", "d": ["Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004735", "l": "pyrroline-5-carboxylate reductase activity", "d": ["Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31219", "l": "5-hydroxykynurenamine + CO2 = 5-hydroxy-L-kynurenine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11911", "l": "H2O + nonane-4,6-dione <=> butanoate + H(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71531", "l": "guanine(out) = guanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24132", "l": "UDP-alpha-D-galactose = UDP-alpha-D-galactofuranose", "d": [], "t": []}, {"i": "EC:5.4.99.9", "l": "\"UDP-galactopyranose mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19992", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate <=> S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380311", "l": "Recruitment of Plk1 to centrosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132759", "l": "TCN1 binds RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198611", "l": "AKT phosphorylates IKKalpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102168", "l": "5-methyl-phenazine-1-carboxylate N-methyltransferase activity", "d": ["Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63324", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784765", "l": "p-Y705-STAT3 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3204303", "l": "MRE11 binds cytosolic DNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856951", "l": "PP2A demethylation by PPME1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008727", "l": "GDP-mannose mannosyl hydrolase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19191", "l": "CO2 + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] => H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23754", "l": "ADP + all-trans-undecaprenyl phosphate + H(+) => all-trans-undecaprenol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57194", "l": "glycolate + H(+) + L-lysyl-[protein] => H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57307", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP <=> glycolate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395412", "l": "Phosphorylation of SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26379", "l": "cyclic pyranopterin phosphate + diphosphate => GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42694", "l": "[(1->4)-alpha-D-glucosyl](n+2) + phosphate => [(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53338", "l": "H(+) + NADPH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.449651719305677", "identifiers": [{"i": "GO:0005183", "l": "gonadotropin hormone-releasing hormone activity", "d": ["The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75957", "l": "CO2 + formaldehyde + oripavine + succinate => 2-oxoglutarate + O2 + thebaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102138", "l": "7-oxatyphasterol synthase activity", "d": ["Catalysis of the reaction: H+ + typhasterol + NADPH + O2 = 7-oxatyphasterol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090710", "l": "phosphomevalonate decarboxylase activity", "d": ["Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210277", "l": "Interaction of PECAM-1 and SHP-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.683039265630129", "identifiers": [{"i": "GO:0097472", "l": "cyclin-dependent protein kinase activity", "d": ["Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035473", "l": "lipase binding", "d": ["Binding to a lipase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49522", "l": "an adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202966", "l": "Caspase mediated cleavage of HIP-55 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800380", "l": "PTPRD binds IL1RAP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61031", "l": "itaconate + L-cysteinyl-[protein] <=> S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865774", "l": "TTLLs polyglutamylate tubulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65615", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508292", "l": "SYK binds IL2RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30957", "l": "7,7',9,9'-tetra-cis-lycopene + 2 a quinol => 9,9'-di-cis-zeta-carotene + 2 a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70365", "l": "1-carboxybiuret + H(+) => cyanurate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295613", "l": "SPRY2 binds GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62031", "l": "H2O + stigmasteryl 3-beta-D-glucoside <=> D-glucose + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391939", "l": "TP receptor can bind thromboxane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799409", "l": "HIPK2 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444511", "l": "Formation of MSH2:MSH3 Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69789", "l": "3-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52630", "l": "a fatty acid + an L-alpha-amino acid => an N-fatty-acyl-L-alpha-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64455", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12465", "l": "myo-inositol + UDP-alpha-D-galactose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202233", "l": "Inactivation of Lck by Csk (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69596", "l": "AMP + inosine = adenosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39175", "l": "(3R)-hydroxyeicosanoyl-CoA = (2E)-eicosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31838", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30366", "l": "fumonisin B1 + 2 H2O <=> (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928639", "l": "p-EFNB binds GRB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38614", "l": "NAD(+) <=> cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30822", "l": "allantoin + H2O <=> allantoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139898", "l": "Caspase-8 activates BID by cleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452097", "l": "Recruited STAT5 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64794", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+) => L-lysine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67617", "l": "8-oxo-GTP + H2O => 8-oxo-GMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17227", "l": "6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22576", "l": "an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.81", "l": "\"quorum-quenching N-acyl-homoserine lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163090", "l": "Elongation Of The Telomeric Chromosome End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53246", "l": "cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199203", "l": "PANK1/3 phosphorylate PanK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20306", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66860", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16645", "l": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate", "d": [], "t": []}, {"i": "EC:3.1.2.2", "l": "\"palmitoyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878117", "l": "RUNX3 binds ZFHX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15841", "l": "D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35910", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007640", "l": "RBBP4 gene expression is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623168", "l": "FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76607", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O = (12Z,15Z)-10-hydroxyoctadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18965", "l": "hydroxymethylbilane = H2O + uroporphyrinogen III", "d": [], "t": []}, {"i": "EC:4.2.1.75", "l": "\"uroporphyrinogen-III synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046989", "l": "galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102790", "l": "cyanidin 5,3-O-glycosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53535", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate <=> (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27539", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25182", "l": "acetyl-CoA + putrescine => CoA + H(+) + N-acetylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015016", "l": "[heparan sulfate]-glucosamine N-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31823", "l": "(2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.91", "l": "\"cubebol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380508", "l": "Translocation of NuMA to the centrosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42475", "l": "dibenzo-p-dioxin + NADH + O2 <=> 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14532", "l": "ADP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052661", "l": "S-lactaldehyde reductase activity", "d": ["Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690740", "l": "CD22 binds B-cell receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689317", "l": "Formation of the pre-incision complex in GG-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817575", "l": "ERO1B oxidizes P4HB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202960", "l": "Caspase mediated cleavage of C-IAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003939", "l": "L-iditol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204824", "l": "Interaction of Tie2 and Ang4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26361", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": [], "t": []}, {"i": "EC:4.1.99.19", "l": "\"2-iminoacetate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034880", "l": "citrazinate dehydrogenase activity", "d": ["Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28328", "l": "D-glucuronate + H(+) + wogonin => H2O + wogonin 7-O-beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005117", "l": "wishful thinking binding", "d": ["Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14644", "l": "cyanurate + H2O <=> biuret + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247513", "l": "STAB1:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39446", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373741", "l": "SDK2 homophillic interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32145", "l": "L-arginine(out) => L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50948", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.38", "l": "\"single-stranded DNA cytosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20360", "l": "3-phenylpropanoate + H(+) + NADH + O2 <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50907", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22756", "l": "a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33917", "l": "H2O2 + methylamine + succinate semialdehyde => 4-(methylamino)butanoate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216040", "l": "Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902098", "l": "calcitriol binding", "d": ["Binding to calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396009", "l": "STING binds c-di-GMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19753", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": [], "t": []}, {"i": "EC:6.3.1.14", "l": "\"diphthine--ammonia ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21386", "l": "(E)-cinnamate + NH4(+) => L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015021", "l": "heparin-sulfate lyase activity", "d": ["Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75551", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH = AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69168", "l": "H2O + NAD(+) + spermine monoaldehyde = 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21879", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) <=> (S)-usnate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37089", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59650", "l": "D-xylotrionate + H(+) => D-xylotriono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76462", "l": "(E)-sinapyl alcohol + A <=> (E)-sinapaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103068", "l": "leukotriene C4 gamma-glutamyl transferase activity", "d": ["Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71079", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] = cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010290", "l": "chlorophyll catabolite transmembrane transporter activity", "d": ["Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349455", "l": "Phosphorylation of MDM4 by ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66741", "l": "ATP + H2O + N-acetyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56745", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 => (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52046", "l": "H(+) + mogroside IE + UDP => mogrol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40102", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981606", "l": "Myoglobin binds oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30231", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine = (2E,6E)-farnesal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862771", "l": "PLA2G2A binds bacterial phospholipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76672", "l": "furfural + H2O + NADP(+) => 2-furoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61084", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050367", "l": "tyrosine-arginine ligase activity", "d": ["Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54105", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45061", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine => (9Z)-octadecenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66913", "l": "avenanthramide C + S-adenosyl-L-methionine => avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33962", "l": "2-oxoglutarate + neomycin C <=> 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75009", "l": "H(+)(in) + VO(2+)(in) => H(+)(out) + VO(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878054", "l": "HIPK2 phosphorylates RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161567", "l": "LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49737", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74386", "l": "2 (S)-lactate(in) + prostaglandin E2(out) <=> 2 (S)-lactate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169683", "l": "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626914", "l": "α2-agonists bind ADRA2A,B,C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45950", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] => acetyl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74994", "l": "Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36368", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O => 2-hydroxyglutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52181", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36107", "l": "gibberellin A4 + S-adenosyl-L-methionine = O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29040", "l": "ATP + H2O + L-aspartate(out) => ADP + H(+) + L-aspartate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944261", "l": "Association of procollagen type XIII (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15946", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018756", "l": "RHOH binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31159", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15968", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34242", "l": "L-glutamate <=> 3-aminopentanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35991", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42715", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA <=> 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18142", "l": "NAD(+) + trans-cyclohexane-1,2-diol => 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28304", "l": "diphosphate + germacrene C => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174203", "l": "SCF-mediated degradation of Emi1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16348", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76722", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74234", "l": "H2O + L-threonyl-tRNA(Val) <=> L-threonine + tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42692", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": [], "t": []}, {"i": "EC:2.4.99.16", "l": "\"starch synthase (maltosyl-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36271", "l": "caffeine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.113", "l": "\"pestivirus NS3 polyprotein peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70168", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37068", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47849", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935988", "l": "OCLN (Occludin) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003868", "l": "4-hydroxyphenylpyruvate dioxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3221982", "l": "BANP binds TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005457", "l": "GDP-fucose transmembrane transporter activity", "d": ["Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229283", "l": "LCNs bind lipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41162", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30270", "l": "2 monodehydro-L-ascorbate radical <=> L-ascorbate + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62381", "l": "carbaryl + H(+) + H2O => 1-naphthol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37130", "l": "2-oxoglutarate + dioxidophosphate + H2O2 <=> CO2 + H(+) + phosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18623", "l": "a (2R,3R)-dihydroflavonol + CO2 + succinate => 2-oxoglutarate + a (2S)-flavan-4-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57980", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside F1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51049", "l": "5alpha-androstan-3,17-dione + A => AH2 + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62899", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70812", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097160", "l": "polychlorinated biphenyl binding", "d": ["Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-442749", "l": "CaMKK autophosphorylates in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880053", "l": "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29736", "l": "butane-1-sulfonate + FMNH2 + O2 => butanal + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72722", "l": "eIF2 activation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64846", "l": "(2E)-geranyl benzoate + CoA => (2E)-geraniol + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047831", "l": "D-ornithine 4,5-aminomutase activity", "d": ["Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72272", "l": "formate(out) + oxalate(in) => formate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389845", "l": "TUFM:GTP binds aminoacyl-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58617", "l": "N-octanoyl-(2S)-hydroxyglycine => glyoxylate + octanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47728", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26546", "l": "beta-alaninamide + H2O = beta-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164834", "l": "Enzyme-bound ATP is released (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112510", "l": "IL6ST is tyrosine phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.974037860983486", "identifiers": [{"i": "GO:0030546", "l": "signaling receptor activator activity", "d": ["The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.3", "l": "\"pyroglutamyl-peptidase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60747", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1912357", "l": "ITCH ubiquitinates DTX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37629", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353476", "l": "Recruitment of repair factors to form the preincision complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49355", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63177", "l": "(2S)-ibuprofenoyl-CoA => (2R)-ibuprofenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69676", "l": "eriodictyol-7-O-beta-D-glucoside + H2O => (S)-eriodictyol + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65709", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686469", "l": "Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43579", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31204", "l": "acetyl-CoA + hexanoyl-CoA => 3-oxooctanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37517", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28762", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose <=> alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68610", "l": "Formation of ORC(2-5) complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018857", "l": "2,4-dichlorobenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61178", "l": "CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside] => (E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73033", "l": "Cd(2+)(in) + H(+)(in) => Cd(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43316", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786650", "l": "DDHD1,2 hydrolyse PA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010542", "l": "nitrate efflux transmembrane transporter activity", "d": ["Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66325", "l": "iodide(out) => iodide(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73068", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O => an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66064", "l": "2-oxohexanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791016", "l": "SFTPB binds itself (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839094", "l": "Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835171", "l": "Budding of hRSV A virions from infected cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0070567", "l": "cytidylyltransferase activity", "d": ["Catalysis of the transfer of a cytidylyl group to an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696605", "l": "USP12, USP26 deubiquitinate AR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47655", "l": "D-ribitol 1-phosphate + H2O <=> phosphate + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42347", "l": "H(+) + NADH + O2 + p-cumate <=> (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203611", "l": "N-myristoylation of eNOS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74870", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) <=> (E)-caffeoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24934", "l": "H2O + L-cysteine <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034590", "l": "L-hydroxyproline transmembrane transporter activity", "d": ["Enables the transfer of L-hydroxyproline from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-6784213", "l": "Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40676", "l": "L-threonine => 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.-", "l": "\"Other carbon--nitrogen ligases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18647", "l": "NH4(+) + sym-homospermidine => 2 putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328129", "l": "Dystroglycan binds Laminins and Dystrophin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23508", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate", "d": [], "t": []}, {"i": "EC:3.5.1.93", "l": "\"glutaryl-7-aminocephalosporanic-acid acylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68775", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353356", "l": "Reversal of Alkylation Damage By DNA Dioxygenases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052860", "l": "2'-deoxymugineic-acid 3-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62797", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B => aurasperone A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21020", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.5", "l": "\"chorismate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67834", "l": "CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760097", "l": "AcK-NFE2L2 and MAFK bind the GSTA1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15065", "l": "H2O + N(4)-benzoylagmatine = agmatine + benzoate", "d": [], "t": []}, {"i": "EC:3.5.1.40", "l": "\"acylagmatine amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670114", "l": "Histone H3.3 deposition at telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334794", "l": "FABPs bind LCFAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005174", "l": "CD40 receptor binding", "d": ["Binding to CD40, a receptor found on the surface of all B-lymphocytes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63125", "l": "H2O + N-octadecanoyl ethanolamine => ethanolamine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57333", "l": "H2O + 3 O2 + 3 propionate 3-nitronate => 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9822539", "l": "VWF multimer binds to collagen type I (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65586", "l": "8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869560", "l": "The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205205", "l": "Interaction of Src family kinases with p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004846", "l": "urate oxidase activity", "d": ["Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33003", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449978", "l": "IL7 binds IL7R:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20812", "l": "(3S)-citryl-CoA = acetyl-CoA + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.1.3.34", "l": "\"citryl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212614", "l": "Glutamine transport from astrocytes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48630", "l": "a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77386", "l": "H(+) + hnu + octanoate <=> CO2 + heptane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17317", "l": "chlorophyllide a + H(+) + phytyl diphosphate = chlorophyll a + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.62", "l": "\"chlorophyll synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18706", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517705", "l": "p-S318,221-HuR binds mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174097", "l": "Association of Emi1 with Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.46", "l": "\"L-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450088", "l": "GLUT1 tetramer binds 4xATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13145", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.4.1.320", "l": "\"1,4-beta-mannosyl-N-acetylglucosamine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13557", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.3", "l": "\"glutathione synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102395", "l": "9-cis-beta-carotene 9',10'-cleavage oxygenase activity", "d": ["Catalysis of the reaction: 9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43377", "l": "5'-deoxyinosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45014", "l": "(4R)-hydroxysphinganine + octadecanoate => H2O + N-octadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013435", "l": "RHOD auto-activates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77550", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57566", "l": "7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70460", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39478", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0061604", "l": "molybdopterin-synthase sulfurtransferase activity", "d": ["Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34269", "l": "CoA + fumigaclavine A => acetyl-CoA + fumigaclavine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69235", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O <=> (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389354", "l": "Activation of Vav1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41579", "l": "dTDP-beta-L-mycarose + erythronolide B <=> 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17489", "l": "H(+) + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.7", "l": "\"phthalate 4,5-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799431", "l": "TP53 binds HIPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.432554362561859", "identifiers": [{"i": "GO:0015293", "l": "symporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380316", "l": "Association of NuMA with microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21177", "l": "L-idonate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13194", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400204", "l": "PPARA binds RXRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32200", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73757", "l": "Binding of RRN3 to RNA Polymerase I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25856", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0016726", "l": "oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP."], "t": []}, {"i": "EC:1.17.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51756", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49309", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside nLc4Cer(d18:0) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.504650478785891", "identifiers": [{"i": "GO:0016684", "l": "oxidoreductase activity, acting on peroxide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.11.-.-", "l": "\"Acting on a peroxide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62566", "l": "(4S)-perillyl alcohol + AH2 => (4S)-limonene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869580", "l": "DEK binds TFAP2A homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13347", "l": "diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65769", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12170", "l": "acrolein + H(+) + NADPH => allyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009282", "l": "CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062070", "l": "SAGA complex binding", "d": ["Binding to a SAGA complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28157", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29375", "l": "AMP + H2O = adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58793", "l": "ATP + Fe(III)-petrobactin(out) + H2O => ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702593", "l": "lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33201", "l": "butanal + H(+) + NADH => butan-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005142", "l": "interleukin-11 receptor binding", "d": ["Binding to an interleukin-11 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042943", "l": "D-amino acid transmembrane transporter activity", "d": ["Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42724", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.167", "l": "\"27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31254", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O <=> (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683925", "l": "ULK1 is dephosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018506", "l": "maleylacetate reductase activity", "d": ["Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11164", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.17", "l": "\"phosphatidylethanolamine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10274", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+) => a 1,2-diacyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34537", "l": "1-deoxy-3-dehydrosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73809", "l": "N(7)-methyl-GDP + S-adenosyl-L-homocysteine => GDP + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59292", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O = D-galactose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004410", "l": "homocitrate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36508", "l": "docosanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140773", "l": "NAD-dependent protein demyristoylase activity", "d": ["Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:70567", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21687", "l": "(R)-beta-alanopine + H2O + NAD(+) <=> beta-alanine + H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75006", "l": "ATP + CoA + sulfoacetate <=> AMP + diphosphate + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251942", "l": "Hikeshi binds HSP70s:ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32181", "l": "dipicolinate + H(+) + NADH => (S)-2,3-dihydrodipicolinate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43093", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA => 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170120", "l": "Translocation of Cdc25B to the cytoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047773", "l": "carnitinamidase activity", "d": ["Catalysis of the reaction: (R)-carnitinamide + H2O = (R)-carnitine + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070736", "l": "protein-glycine ligase activity, initiating", "d": ["Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69905", "l": "cytidine(in) + 2 Na(+)(in) => cytidine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63633", "l": "a long-chain fatty acyl-AMP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11026", "l": "ADP + 2 H(+) + phosphoramidate => ATP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40188", "l": "(2E)-octenoyl-CoA + H2O => (3R)-hydroxyoctanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76927", "l": "3-aminopentane + H2O + NADP(+) = H(+) + NADPH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437932", "l": "p-Y348-SYK binds VAV family (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30178", "l": "15-cis-phytoene + 2 plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951727", "l": "cAMP binds PKA tetramer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74639", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) = AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786650", "l": "DDHD1,2 hydrolyse PA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679239", "l": "ULK complex translocates to the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164506", "l": "Gap repair completes provirus integration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184323", "l": "Monoubiquitination of N-myristoyl GAG polyprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421218", "l": "xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70389", "l": "CoA + H(+) + N-octadecanoyl-3-oxosphinganine => 3-oxosphinganine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16416", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] <=> L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60245", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016498", "l": "neuromedin K receptor activity", "d": ["Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46252", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69266", "l": "an isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64427", "l": "H(+)(out) + L-leucyl-L-proline(out) <=> H(+)(in) + L-leucyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23441", "l": "4-chlorobenzoate + H2O => 4-hydroxybenzoate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28584", "l": "ADP + dUTP => ATP + dUDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73211", "l": "H(+)(in) + sucrose(out) = H(+)(out) + sucrose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10142", "l": "H(+) + NADPH + prostaglandin D2 => NADP(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31750", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46041", "l": "2'-deoxycytidine + ATP => ADP + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866277", "l": "AP-2 directly binds some endocytic cargo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390663", "l": "ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76266", "l": "ergothioneine(in) <=> ergothioneine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005298", "l": "proline:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473594", "l": "Collagen type II degradation by MMP15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25135", "l": "phosphate + pyridoxamine = H2O + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10209", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102096", "l": "decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24318", "l": "(+)-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005161", "l": "platelet-derived growth factor receptor binding", "d": ["Binding to a platelet-derived growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54796", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) = an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.412", "l": "\"2-alkyl-3-oxoalkanoate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010872", "l": "SLIT2 binds Dystroglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.178", "l": "\"steroid 22S-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71488", "l": "H2O + Leu-enkephalin => L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416698", "l": "SEMA5A binds to PLXNB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41588", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35430", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222093", "l": "BRD7 binds TP53 and EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50052", "l": "ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39015", "l": "22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102448", "l": "rhamnetin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = ombuin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58228", "l": "L-asparaginyl-[protein] + NAD(+) = H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450474", "l": "MK2 phosphorylates BRF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29404", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 => 3-demethylubiquinol-8 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102294", "l": "cholesterol dehydrogenase activity", "d": ["Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19901", "l": "L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.10", "l": "\"tryptophan alpha,beta-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76855", "l": "2-aminopentane + H2O + NAD(+) = H(+) + NADH + NH4(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60004", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76469", "l": "8-demethyltetracenomycin C + H2O + 2 NADP(+) => 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66602", "l": "2 dopamine quinone + 2 H2O => 2 dopamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668605", "l": "RAC2:GTP binds NOX2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55039", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "54.481932467997161", "identifiers": [{"i": "GO:0022843", "l": "voltage-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76269", "l": "carnosine(out) => carnosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951499", "l": "Loading of antigenic peptides on to class I MHC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112271", "l": "The receptor:G-protein complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73257", "l": "(2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine => (2S)-sakuranetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090686", "l": "glycine betaine-activated nonselective monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70919", "l": "chloride(out) + dopamine(out) + Na(+)(out) = chloride(in) + dopamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63967", "l": "sphinga-4E,14Z-dienine-1-phosphate <=> (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937807", "l": "SRC phosphorylates RUNX3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12557", "l": "6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11273", "l": "a (2R)-2-hydroxycarboxylate + a quinone => a 2-oxocarboxylate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237129", "l": "Acireductone is created (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.56", "l": "\"insulysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015204", "l": "urea transmembrane transporter activity", "d": ["Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372542", "l": "Loading of dopamine into synaptic veiscles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69664", "l": "H2O + luteolin 7-O-beta-D-glucoside => beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69618", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621410", "l": "HMGCR gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046175", "l": "Further sulfation on galactose residues produces KSPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26248", "l": "geranylgeranyl diphosphate <=> diphosphate + fusicocca-2,10(14)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247843", "l": "secretion of WNT ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664275", "l": "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45692", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) = N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684336", "l": "nsp1-4 cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72378", "l": "hydrogencarbonate(out) + iodide(in) <=> hydrogencarbonate(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43425", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47624", "l": "cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.171", "l": "\"cis-L-3-hydroxyproline dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004454", "l": "ketohexokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56748", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75967", "l": "(6-hydroxyhexanoyl)n + H2O = (6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69329", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49088", "l": "FAD + H(+) + H2O + squalene = FADH2 + hydroxysqualene", "d": [], "t": []}, {"i": "EC:1.17.8.1", "l": "\"hydroxysqualene dehydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10336", "l": "citrate = D-threo-isocitrate", "d": [], "t": []}, {"i": "EC:4.2.1.3", "l": "\"aconitate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0018822", "l": "nitrile hydratase activity", "d": ["Catalysis of the reaction: an aliphatic amide = a nitrile + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22000", "l": "D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13965", "l": "H2O + L,L-cystathionine = L-homocysteine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58495", "l": "ATP + Fe(III)-enterobactin(out) + H2O <=> ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724685", "l": "IgE binds omalizumab (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0090600", "l": "alpha-1,3-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73652", "l": "CTP(out) => CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047246", "l": "luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21992", "l": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806957", "l": "MET receptor dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66315", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O <=> a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58512", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604763", "l": "Autocatalytic activation of MMP7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392870", "l": "Gs activation by prostacyclin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76574", "l": "4-deoxy-L-erythro-hex-4-enopyranuronate <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62886", "l": "2 (M)-viriditoxin + 2 H2O => O2 + 4 semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52669", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50117", "l": "eicosanoyl-CoA + taurine => CoA + H(+) + N-eicosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70621", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483219", "l": "PC is exchanged with PI by PITPNB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24564", "l": "a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65650", "l": "a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53292", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin = H(+) + N-carbamoyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14411", "l": "H(+) + hypotaurine => cysteamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624120", "l": "CEBPA binds CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592436", "l": "Initial activation of proMMP9 by MMPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21652", "l": "2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030170", "l": "pyridoxal phosphate binding", "d": ["Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71158", "l": "(E)-caffeoylpyruvate + H2O <=> (E)-caffeate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51191", "l": "nitric oxide + superoxide <=> peroxynitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52779", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39587", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37133", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41256", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46718", "l": "H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine => pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13677", "l": "D-ribulose 5-phosphate = D-xylulose 5-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.1", "l": "\"ribulose-phosphate 3-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014433", "l": "RHOG GEFs activate RHOG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76920", "l": "4-methyl-cyclohexylamine + H2O + NADP(+) => 4-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77695", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102880", "l": "isobazzanene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = isobazzanene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428917", "l": "G13 activation by TP receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22631", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58463", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59798", "l": "CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030269", "l": "tetrahydromethanopterin S-methyltransferase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016720", "l": "delta12-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: AH(2) + linoleate + O2 = A + crepenynate + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724745", "l": "PLG(20-810) binds aprotinin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3782637", "l": "HDAC8 deacetylates histones (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047142", "l": "enzyme-thiol transhydrogenase (glutathione-disulfide) activity", "d": ["Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51735", "l": "glandicoline B + S-adenosyl-L-methionine <=> H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14633", "l": "ATP + H2O + Na(+)(in) = ADP + H(+) + Na(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11130", "l": "2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA => 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964496", "l": "STING binds TRIM32 or TRIM56  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43221", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364042", "l": "APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093329", "l": "EFNBs bind SDCBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60463", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139895", "l": "tBID activates BAK protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296326", "l": "HCAR1 binds LACT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51099", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53240", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004856", "l": "xylulokinase activity", "d": ["Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981621", "l": "Neuroglobin:oxygen dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167415", "l": "G-protein alpha subunit is inactivated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30994", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70316", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11580", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.11", "l": "\"CDP-diacylglycerol--inositol 3-phosphatidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37469", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21571", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O <=> beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36276", "l": "H(+) + NADPH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47078", "l": "17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+) => 17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047492", "l": "xanthan lyase activity", "d": ["Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380780", "l": "Activation of Src (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42221", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008864", "l": "formyltetrahydrofolate deformylase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015115", "l": "silicate transmembrane transporter activity", "d": ["Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41675", "l": "1-O-hexadecyl-sn-glycerol + ATP <=> 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67814", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20166", "l": "H2O + N(5)-acyl-L-ornithine ester => an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13019", "l": "5-phospho-alpha-D-ribose 1-diphosphate + uracil => diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534388", "l": "Progesterone Activation Of CatSper (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112392", "l": "Resumption of elongation after recovery from pausing (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68882", "l": "AMP + diphosphate + NADP(+) + salicylaldehyde => ATP + H(+) + NADPH + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70007", "l": "anthranilate + ATP + H(+) = 2-aminobenzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990829", "l": "C-rich single-stranded DNA binding", "d": ["Binding to C-rich, single-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13053", "l": "L-phenylalanine + pyruvate = 3-phenylpyruvate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.58", "l": "\"phenylalanine(histidine) transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16225", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate", "d": [], "t": []}, {"i": "EC:3.5.2.12", "l": "\"6-aminohexanoate-cyclic-dimer hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611852", "l": "ADRB3 bind ADR,NAd (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74936", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 => (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106438", "l": "protein-glutamic acid ligase activity, elongating", "d": ["Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate."], "t": []}, {"i": "RHEA:60148", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54763", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide <=> 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43840", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404200", "l": "IGF1,2 binds IGF1R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433711", "l": "Cis-homodimerization of nectins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46803", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028724", "l": "AMOT proteins bind YAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70241", "l": "PCK1 phosphorylates OA to yield PEP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51652", "l": "D-mannonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71811", "l": "3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186786", "l": "Autophosphorylation of PDGF beta receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014467", "l": "RHOG binds effectors at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31481", "l": "H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP => soyasapogenol A + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047585", "l": "4-pyridoxolactonase activity", "d": ["Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61887", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665998", "l": "MKL1 binds SRF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68379", "l": "glyoxylate + L-asparagine <=> 2-oxosuccinamate + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26387", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal => all-trans-8'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61721", "l": "a D-guloside + NAD(+) => a 3-dehydro-D-guloside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691219", "l": "NOTCH1 HD domain mutants bind DLL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372559", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19217", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": [], "t": []}, {"i": "EC:4.5.1.1", "l": "\"DDT-dehydrochlorinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016208", "l": "AMP binding", "d": ["Binding to AMP, adenosine monophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72204", "l": "2 chloride(out) + hydrogencarbonate(in) => 2 chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16247", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22650", "l": "apo-[cytochrome c] + heme b => holo-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19936", "l": "alpha-D-glucose 1-phosphate + H2O <=> D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201629", "l": "Caspase-mediated cleavage of Tau (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66716", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50249", "l": "ATP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986083", "l": "USP33 deubiquitinates ROBO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67484", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}, {"i": "EC:3.6.1.62", "l": "\"5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112436", "l": "Formation of Elongin complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005055", "l": "laminin receptor activity", "d": ["Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23372", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": [], "t": []}, {"i": "EC:6.3.2.8", "l": "\"UDP-N-acetylmuramate--L-alanine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44339", "l": "an L-alpha-amino acid + ATP + L-arginine <=> ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65024", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) = dehydrocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37793", "l": "aclacinomycin Y + H2O2 => aclacinomycin A + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13480", "l": "H2O + L-tryptophan + NADP(+) <=> H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784765", "l": "p-Y705-STAT3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932070", "l": "ESR1 binds the AXIN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.72", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052880", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein."], "t": []}, {"i": "EC:1.10.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24373", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] => H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11552", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.71", "l": "\"acetylalkylglycerol acetylhydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54273", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74885", "l": "GUCYs converts GTP to cGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69053", "l": "RFC binding displaces Pol Alpha (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13040", "l": "ATP + H(+) + H2O <=> ITP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48920", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.14", "l": "\"3,8-divinyl chlorophyllide a reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20552", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664918", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42572", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) = 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53217", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336443", "l": "LIN7, CASK and APBA1 bind (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76842", "l": "H2O + NAD(+) + propylamine <=> H(+) + NADH + NH4(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875443", "l": "USP8 deubiquitinates LRIG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10503", "l": "butanoyl-CoA + glyoxylate + H2O <=> 3-ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445705", "l": "Release Of ADP From Myosin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36565", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH => GDP-beta-L-colitose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428123", "l": "KDSR reduces 3-ketosphingoid (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010647", "l": "ROBO3.1 binds AKAP5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0038182", "l": "G protein-coupled bile acid receptor activity", "d": ["Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47401", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA => (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27970", "l": "D-maltotriose + H2O = alpha-D-glucose + D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73714", "l": "ATP(in) + UTP(out) <=> ATP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29354", "l": "Zn(2+)(in) <=> Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59729", "l": "(2R)-ethylmalonyl-CoA => (2S)-ethylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.56", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69195", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77173", "l": "biotin + L-lysine => biocytin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015233", "l": "pantothenate transmembrane transporter activity", "d": ["Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35560", "l": "H(+) + menaquinone-7 + NADH => menaquinol-7 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836270", "l": "TFAP2A binds TFAP2C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646295", "l": "p14ARF mutant does not translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534096", "l": "METAP1/2 demethylates GNAT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54070", "l": "diphosphate + sesterfisherol => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21438", "l": "[translation elongation factor 2]-phosphate + ADP + H(+) => [translation elongation factor 2] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24681", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde <=> 5,10-methylenetetrahydromethanopterin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50425", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 => prostaglandin G1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57990", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45018", "l": "L-selenomethionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008803", "l": "bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity", "d": ["Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52799", "l": "2 H(+) + Ni-sirohydrochlorin <=> Ni(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047601", "l": "acetate kinase (diphosphate) activity", "d": ["Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10636", "l": "D-mannonate + NADP(+) = D-mannuronate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052790", "l": "chitooligosaccharide deacetylase activity", "d": ["Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54082", "l": "5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67164", "l": "bromide + FADH2 + melleolide F + O2 = 6'-bromomelleolide F + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31253", "l": "(S)-3-hydroxy-2-methylpropanoate + CoA + H(+) => (S)-3-hydroxyisobutanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52850", "l": "5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654167", "l": "Activated FGFR1 binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41244", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849906", "l": "SALM1 binds NMDA receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21337", "l": "NAD(+) + pyridoxal => 4-pyridoxolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61051", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53991", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] <=> L-threonyl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26306", "l": "2-aminophenol + O2 => 2-aminomuconate 6-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62597", "l": "(S)-8-oxocitronellyl enol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849463", "l": "PTK6 phosphorylates SFPQ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33721", "l": "a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14804", "l": "(2R)-3-phosphoglycerate + ATP <=> (2R)-3-phospho-glyceroyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029471", "l": "Hydrolysis of PC to PA by PLD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59983", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64758", "l": "benzylthiol + NH4(+) + pyruvate => H2O + S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68191", "l": "dodecanoyl-CoA + phytol <=> CoA + dodecanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73737", "l": "3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde => O2 + trans-resveratrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29885", "l": "ADP + H(+) + L-ornithine(in) + phosphate => ATP + H2O + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047963", "l": "glycine N-choloyltransferase activity", "d": ["Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50017", "l": "H2O + octanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837136", "l": "SH binds to BCAP31 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69952", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21610", "l": "2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine => isoliquiritigenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72518", "l": "(R)-carnitine(out) + glutarate(in) <=> (R)-carnitine(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76185", "l": "2 H(+)(in) + L-alanyl-L-alanine(in) => 2 H(+)(out) + L-alanyl-L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36917", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69668", "l": "H2O + luteolin 4'-O-beta-D-glucoside => beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013021", "l": "GDIs block activation of RHOB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12429", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH => benzene-1,2,4-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74105", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17806", "l": "H2O + S-adenosyl-L-homocysteine => adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77322", "l": "N(omega)-methyl-L-arginine + pyruvate <=> 5-(3-methylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38175", "l": "all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997237", "l": "SH2B proteins bind JAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12213", "l": "9H-fluoren-9-ol + NADP(+) => 9H-fluoren-9-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14820", "l": "4-maleylacetoacetate <=> 4-fumarylacetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373724", "l": "Nephrin binds NCK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867344", "l": "OMA1 hydrolyses OPA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432455", "l": "Nuclear PER is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74778", "l": "kaempferide + S-adenosyl-L-methionine <=> 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46191", "l": "an aliphatic nitrile + 2 H2O <=> a carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67102", "l": "fumigatonoid C => fumigatonoid B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395227", "l": "CCND1:CREBBP binds NOTCH1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66980", "l": "2-methylbutanoyl-CoA + H2O = 2-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981093", "l": "IL12 bound to IL12R internalises (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855111", "l": "VLDLR binds PCSK9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54631", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 <=> 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809707", "l": "MTMR12 binds MTMR2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.45", "l": "\"2-dehydro-3-deoxygluconokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617879", "l": "HOXA4 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51918", "l": "2-oxobutanoate + NH4(+) => (2S)-2-amino-3-butenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66833", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + preasperterpenoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939904", "l": "Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47225", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63824", "l": "2 3-(4-hydroxyphenyl)pyruvate = aspulvinone E + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38125", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18076", "l": "(S)-dihydroorotate + A <=> AH2 + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45528", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66086", "l": "H2O + kynurenate + L-aspartate => L-kynurenine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.14", "l": "\"polyamine oxidase (propane-1,3-diamine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9669854", "l": "KIT binds type II TKIs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4167511", "l": "HLCS biotinylates ACACB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694527", "l": "Loss of SAR1B GTPase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607746", "l": "PKC-delta is activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67283", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15651", "l": "CO2 + NH4(+) => carbamate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14258", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016170", "l": "interleukin-15 receptor binding", "d": ["Binding to an interleukin-15 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60255", "l": "(S)-methylmalonyl-CoA + NADP(+) <=> acryloyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870461", "l": "RABGGTA and RABGGTB bind (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77081", "l": "Formation of the CE:GMP intermediate complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40501", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434637", "l": "PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32691", "l": "(2E)-geranyl diphosphate = (E)-beta-ocimene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.106", "l": "\"(E)-beta-ocimene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69308", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = phenylacetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043907", "l": "Cys-tRNA(Pro) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390674", "l": "ADRB1 bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627107", "l": "XIAP binds CASP7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046025", "l": "precorrin-6Y C5,15-methyltransferase (decarboxylating) activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352268", "l": "Cleavage of Satb1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48723", "l": "aurachin B + H2O + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15088", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36706", "l": "(2S,5S)-5-carboxymethylproline + ATP <=> (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419861", "l": "Melanospin is stimulated by light (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141106", "l": "tRNA methyltransferase activator activity", "d": ["Binds to and increases the activity of a methyltransferase."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879459", "l": "F-actin capping protein is a heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73797", "l": "FAICAR => IMP + H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27630", "l": "ethylene glycol + NAD(+) = glycolaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13143", "l": "butanoyl-CoA => 2-methylpropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008906", "l": "inosine kinase activity", "d": ["Catalysis of the reaction: ATP + inosine = ADP + IMP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443774", "l": "Trans-homodimerization of Neurofascin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103040", "l": "aldose sugar dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10347", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39789", "l": "19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35260", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067667", "l": "IL6 binds IL6R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357472", "l": "PAK1-3 autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851068", "l": "Crizotinib-driven IL10RA gene expression in NPM1-ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928656", "l": "gamma-secretase cleaves EPHB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12477", "l": "H2O + N-formyl-L-glutamate => formate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607734", "l": "PKC-delta translocates to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17827", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061863", "l": "microtubule plus end polymerase", "d": ["Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009383", "l": "rRNA (cytosine-C5-)-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694527", "l": "Loss of SAR1B GTPase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40191", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47363", "l": "decanoate ester + H2O <=> an aliphatic alcohol + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416690", "l": "SEMA4A binds to PLXND1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0004532", "l": "RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule."], "t": []}, {"i": "REACT:R-HSA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034573", "l": "didemethylisoproturon amidohydrolase activity", "d": ["Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46050", "l": "alpha-D-galactosamine 1-phosphate => D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32792", "l": "L-ectoine(in) => L-ectoine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67653", "l": "dADP + H2O => 2'-deoxyadenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77466", "l": "furan-3-carbaldehyde + hydrogen cyanide <=> (2S)-2-(furan-3-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29652", "l": "agmatine(in) + L-arginine(out) => agmatine(out) + L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51012", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O = a monoacylglycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49425", "l": "ATP + validone => ADP + H(+) + validone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419861", "l": "Melanospin is stimulated by light (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57887", "l": "diphosphate + H2O + Na(+)(in) <=> H(+) + Na(+)(out) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0004308", "l": "exo-alpha-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954179", "l": "S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382053", "l": "Translocation of PDGF from ER to Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23370", "l": "benzaldehyde + CO2 => H(+) + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58524", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH = (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32241", "l": "all-trans-beta-carotene => gamma-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664397", "l": "IgG binds LPG1G2 in the amastigote form of Leishmania (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.78", "l": "\"arogenate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47902", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate => a ganglioside GM3 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451811", "l": "YKI binds to WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46708", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] = AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58918", "l": "(S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3204303", "l": "MRE11 binds cytosolic DNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25081", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) <=> 4-methyl-2-oxopentanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35941", "l": "diphosphate + tryprostatin B => brevianamide F + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25271", "l": "(R)-adrenaline + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62139", "l": "dGMP + GTP <=> dGDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0045142", "l": "triplex DNA binding", "d": ["Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48142", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite => 2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18556", "l": "(2R,3S)-tartrate + NAD(+) <=> dihydroxyfumarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19912", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23581", "l": "prostaglandin H2 => prostaglandin I2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33101", "l": "CoA + H(+) + N(1)-acetylspermine => acetyl-CoA + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50778", "l": "(E)-hex-2-enal + H(+) + NADPH => hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685604", "l": "SLAMF6 binds SLAMF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38129", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140293", "l": "ADP-ribosylglutamate hydrolase activity", "d": ["Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15671", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+) => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879942", "l": "The receptor is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912410", "l": "NOTCH4 mRNA translation controlled by miRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177284", "l": "PKA phosphorylates PDE4B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15172", "l": "H2O + N-succinyl-L-glutamate <=> L-glutamate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835165", "l": "Formation of hRSV A matrix lattice (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48680", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.330", "l": "\"very-long-chain 3-oxoacyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18199", "l": "cyclohexyl isocyanide + H2O => N-cyclohexylformamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62938", "l": "2'-deoxycytidine + acetate + H(+) => H2O + N(4)-acetyl-2'-deoxycytidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205056", "l": "PRDM4 inhibits cyclin E transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15267", "l": "H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate => 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645535", "l": "ALPK1 phosphorylates TIFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45301", "l": "an N-(acyl)-sphingosylphosphocholine + H2O => an N-acyl-sphingoid base + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4411373", "l": "NLK translocates to nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34117", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine => carboxynorspermidine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964619", "l": "PAK1 binds ARHGEF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029460", "l": "PAK1 phosphorylates LIMK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40969", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484822", "l": "Kinetochore assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654603", "l": "Activated FGFR2 binds FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39270", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35050", "l": "adenylyl-molybdopterin + H(+) + molybdate <=> AMP + H2O + Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34419", "l": "(+)-lariciresinol + NADP(+) = (+)-pinoresinol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.23.1.1", "l": "\"(+)-pinoresinol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13784", "l": "an L-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35705", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013435", "l": "RHOD auto-activates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417908", "l": "P2RY1 binds ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62841", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54711", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213200", "l": "Release of endostatin-like peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49236", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose = L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.211", "l": "\"protein-N(pi)-phosphohistidine--sucrose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43363", "l": "an N-acylsphinganine + UDP-alpha-D-glucose <=> an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018754", "l": "GDIs bind RHOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73597", "l": "CTP(in) + dUMP(out) => CTP(out) + dUMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16269", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) = 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.7.1.6", "l": "\"azobenzene reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748991", "l": "XDH oxidises 6MP to 6TU (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810643", "l": "EPPIN protein complex binds bacteria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961636", "l": "E2F1 binds the POLA1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0042900", "l": "arabinose transmembrane transporter activity", "d": ["Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18358", "l": "NADP(+) + tropine => H(+) + NADPH + tropinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69609", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin] => acetyl-CoA + N-terminal L-methionyl-[tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9842656", "l": "ALK binds ALKAL ligand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67902", "l": "glutaryl-CoA + succinate => glutarate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37109", "l": "N(7)-methylguanosine + phosphate => H2O + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43575", "l": "A + D-arginine + H2O <=> 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11574", "l": "chenodeoxycholate + FADH2 => FAD + H(+) + H2O + lithocholate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006850", "l": "IL21 receptor JAK phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62609", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 => S-sulfanylglutathione + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879942", "l": "The receptor is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70950", "l": "L-tryptophan(in) <=> L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67730", "l": "diphosphate + DNA(n)-Z => DNA(n) + dZTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75377", "l": "inosine(out) => inosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727860", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to UBE2I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420233", "l": "VIP receptors bind VIP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64850", "l": "(3Z)-hex-3-en-1-yl benzoate + CoA => (3Z)-hex-3-en-1-ol + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30715", "l": "(2E)-geraniol = (S)-linalool", "d": [], "t": []}, {"i": "EC:5.4.4.4", "l": "\"geraniol isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38467", "l": "a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53378", "l": "H(+) + NADPH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69657", "l": "beta-D-glucose + quercetin => H2O + quercetin 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32130", "l": "2-oxoglutarate + L-proline + O2 <=> cis-4-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66819", "l": "2 Na(+)(in) + tetrahydroxoborate(in) <=> 2 Na(+)(out) + tetrahydroxoborate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29837", "l": "D-galactonate(out) + H(+)(out) => D-galactonate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40124", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21859", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O <=> 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48421", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25402", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70049", "l": "H2O + kynurenate + L-2-aminoadipate => 2-oxoadipate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905574", "l": "ganglioside GM2 binding", "d": ["Binding to ganglioside GM2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.190", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604308", "l": "NICD4 traffics to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15320", "l": "a 2-deoxy-alpha-D-glucoside + H2O <=> 2-deoxy-D-glucose + an alcohol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202966", "l": "Caspase mediated cleavage of HIP-55 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632738", "l": "DDIT4 binds 14-3-3 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46671", "l": "21-hydroxyprogesterone + H(+) + NADPH <=> 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69127", "l": "Formation of the Flap Intermediate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008838", "l": "diaminopropionate ammonia-lyase activity", "d": ["Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64046", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine => (13Z)-docosenoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186765", "l": "PLC-gamma binds to the active receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690461", "l": "FKBP1A binds tacrolimus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58169", "l": "(2E,6E)-farnesyl diphosphate => (-)-5-epi-eremophilene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37800", "l": "2 H(+) + 2 NADH + O2 => 2 H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102641", "l": "(R)-lactaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-propane-1,2-diol + NADP = (R)-lactaldehyde + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44054", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + CoA => alpha,alpha-trehalose + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48007", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420202", "l": "Secretin receptor binds secretin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74331", "l": "O-butanoyl-(R)-carnitine(in) = O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067659", "l": "Assembly of hexameric IL-6 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432010", "l": "Aquaporin-1 passively transports water into cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661625", "l": "FVIII is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592297", "l": "Full activation of MMP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51134", "l": "2-deoxy-D-ribose 5-phosphate + a purine nucleobase => a purine 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47657", "l": "acetyl-CoA + L-methionine sulfone => CoA + H(+) + N-acetyl-L-methionine sulfone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50040", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857336", "l": "CEBPB homodimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31053", "l": "4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+) => (3R)-beta-leucine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70716", "l": "glycine(in) => glycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042813", "l": "Wnt receptor activity", "d": ["Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13277", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.29", "l": "\"cyanophycin synthase (L-aspartate-adding)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14150", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33858", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36179", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39289", "l": "dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59249", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA => (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10367", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O <=> (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13520", "l": "ATP + dTMP <=> ADP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41383", "l": "H(+) + NADH + O2 + toluene <=> 4-methylphenol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027425", "l": "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46125", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473584", "l": "Collagen type III degradation by MMP15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49863", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161733", "l": "PGD2 is dehydrated to PGJ2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047251", "l": "thiohydroximate beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61281", "l": "4-aminobutanoate + H2O + O2 => H2O2 + NH4(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052580", "l": "(+)-pulegone reductase, (-)-menthone as substrate, activity", "d": ["Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830418", "l": "GATA3 binds the LHX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204485", "l": "Basigin binds CyPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211206", "l": "Translocation of DFF to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54363", "l": "4-methyl-2-oxopentanoate + H(+) <=> 3-methylbutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49100", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9770141", "l": "Formation of the Spliceosomal C* complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25609", "l": "beta-D-allofuranose = beta-D-allopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72170", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) <=> 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451311", "l": "Activation of Ca-permeable Kainate receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710353", "l": "GSDMD (1-275) binds cardiolipin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59204", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33855", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67696", "l": "H2O + hexadecanedioyl-CoA = CoA + H(+) + hexadecanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27955", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + presilphiperfolan-8beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296233", "l": "T2Rs bind bitter-tasting compounds (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20722", "l": "CoA + H(+) + L-2-aminoadipate + penicillin G => H2O + isopenicillin N + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3247836", "l": "Retromer recycles WLS to the Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76444", "l": "choline(out) + n Na(+)(out) => choline(in) + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912727", "l": "CBL binds VAV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66808", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH = 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16992", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003691", "l": "double-stranded telomeric DNA binding", "d": ["Binding to double-stranded telomere-associated DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38202", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034947", "l": "terephthalate decarboxylase activity", "d": ["Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24696", "l": "(E)-coniferyl acetate + NADPH => (E)-isoeugenol + acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33474", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21327", "l": "2 H(+) + reduced [rubredoxin] + superoxide <=> H2O2 + oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70512", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12765", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016989", "l": "sigma factor antagonist activity", "d": ["The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709317", "l": "CO binds to free ferrohemoglobin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19232", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000319", "l": "BORA binds PLK1 and AURKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35742", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004854", "l": "xanthine dehydrogenase activity", "d": ["Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865546", "l": "FOXP3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67442", "l": "acetate + L-methionine => H2O + N(alpha)-acetyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75602", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> ectocarpin A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850945", "l": "Casein kinase II phosphorylates PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20482", "l": "3'-phosphoadenylyl sulfate + coelenterazine h => adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050692", "l": "DNA binding domain binding", "d": ["Binding to a protein's DNA binding domain (DBD)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33505", "l": "ADP + H(+) + itraconazole(out) + phosphate => ATP + H2O + itraconazole(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31569", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+) => bisphenol A + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.525080921078057", "identifiers": [{"i": "GO:0019200", "l": "carbohydrate kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule."], "t": []}, {"i": "REACT:R-HSA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27336", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 <=> 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51673", "l": "glyoxal + H2O => glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77318", "l": "glyoxylate + N(omega),N('omega)-dimethyl-L-arginine <=> 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25663", "l": "(2E)-geranyl diphosphate => alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31150", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) <=> 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15864", "l": "3-ADP-2-phosphoglycerate + H2O <=> 3-ADP-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71822", "l": "L-thyroxine(out) <=> L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807872", "l": "Active ARF recruits coatomer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57167", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51848", "l": "8-methylmenaquinone-6 + succinate = 8-methylmenaquinol-6 + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862300", "l": "LYZ binds bacterial peptidoglycan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59918", "l": "(2E)-octenoate + 2 H(+) + NADPH => (2E)-octenal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31638", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030350", "l": "iron-responsive element binding", "d": ["Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57786", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,4-dinitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730858", "l": "Autophosphorylation of BTK/ITK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35082", "l": "doxorubicin(in) <=> doxorubicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032140", "l": "single adenine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007447", "l": "E2F6 forms the PRC1L4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015438", "l": "ABC-type teichoic acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373732", "l": "Nephrin trans-homophilic interaction (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40164", "l": "D-glyceraldehyde + H2O + NADP(+) => (R)-glycerate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44182", "l": "(2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5674019", "l": "BRAP binds KSR1:MARK3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38249", "l": "1-O-hexadecyl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0070492", "l": "oligosaccharide binding", "d": ["Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0035256", "l": "G protein-coupled glutamate receptor binding", "d": ["Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689544", "l": "UCHL5 binds INO80 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156930", "l": "GTP-binding activates eEF2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26093", "l": "(4R)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685602", "l": "NCR3LG1 binds NCR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17232", "l": "acetyl-CoA + an aliphatic alcohol <=> an acetyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24709", "l": "(6R)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30450", "l": "3-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70958", "l": "H(+)(in) + L-glutamate(in) <=> H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420980", "l": "Activation of Ca permeable AMPA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47939", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) <=> 4-hydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13359", "l": "3-oxopropanoate + H(+) + NADH => 3-hydroxypropanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.83", "l": "\"oligopeptidase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70070", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043879", "l": "glycolate transmembrane transporter activity", "d": ["Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)."], "t": []}, {"i": "RHEA:29447", "l": "glycolate(in) = glycolate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432067", "l": "Aquaporin-4 passively transports water out of cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948775", "l": "MKRN1 polyubiquitinates PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71073", "l": "L-arginine(out) + L-cysteine(in) => L-arginine(in) + L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013020", "l": "Activation of GIRK/Kir3 Channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72514", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) <=> (R)-carnitine(in) + 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592436", "l": "Initial activation of proMMP9 by MMPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630795", "l": "p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58425", "l": "(E)-hex-2-en-1-ol + NADP(+) => (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77502", "l": "2-phenylacetaldehyde + hydrogen cyanide <=> (2S)-2-hydroxy-3-phenylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70043", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49356", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44387", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854052", "l": "Formation of the SCF-FBXL7 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49258", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48160", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534388", "l": "Progesterone Activation Of CatSper (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656893", "l": "OPN1MW binds 11cRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46015", "l": "(S)-malate + a quinone <=> a quinol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0004449", "l": "isocitrate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41896", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912727", "l": "CBL binds VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17057", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.141", "l": "\"galactosylacylglycerol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0030276", "l": "clathrin binding", "d": ["Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16274", "l": "an N-acylsphing-4-enine + CDP-choline => a sphingomyelin + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71849", "l": "LDH tetramer reduces PYR to LACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618093", "l": "ATP hydrolysis by HSP90 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38759", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36602", "l": "hydrogen sulfide + NAD(+) <=> NADH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.19", "l": "\"streptothricin hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.133209883971688", "identifiers": [{"i": "GO:0003700", "l": "DNA-binding transcription factor activity", "d": ["A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25986", "l": "(5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70605", "l": "4-ethylphenol + NAD(+) => 4-hydroxystyrene + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63044", "l": "H2O + mevastatin = H(+) + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23847", "l": "ATP + sedoheptulose <=> ADP + D-sedoheptulose 7-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18605", "l": "1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.65", "l": "\"scyllo-inosamine 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27472", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50768", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033460", "l": "GAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140902", "l": "L-glutamine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamine(out) + Na+(out) = L-glutamine(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168888", "l": "Alpha1-Microglobulin binds heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52928", "l": "3',3'-c-di-GMP + 2 H2O = 2 GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61504", "l": "pelargonidin + UDP-alpha-D-glucose = pelargonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51153", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 => 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71294", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) <=> (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54223", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene <=> all-trans-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19196", "l": "A + all-trans-13,14-dihydroretinol <=> AH2 + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051448", "l": "gonadotropin-releasing hormone binding", "d": ["Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63753", "l": "kermesate + UDP-alpha-D-glucose => carminate + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12310", "l": "2 H(+) + L-2-aminoadipate + NADH => (S)-2-amino-6-oxohexanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787737", "l": "CSF3R binds CSF3 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034949", "l": "1,1-dichloroethane reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694522", "l": "Inner coat assembly and cargo binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001588", "l": "dopamine neurotransmitter receptor activity, coupled via Gs", "d": ["Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14333", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}, {"i": "EC:4.6.1.14", "l": "\"glycosylphosphatidylinositol diacylglycerol-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10341", "l": "(2E,6E)-farnesyl diphosphate => (-)-vetispiradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694433", "l": "MIA2 binds PREB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52534", "l": "AMP + GDP + H(+) => adenosine + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46388", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050620", "l": "phycocyanobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75936", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine => 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64339", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA <=> 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54025", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 => (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36677", "l": "CoA + H(+) + N-(octacosanoyl)-sphinganine => octacosanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66164", "l": "butanoyl-CoA + serotonin = CoA + H(+) + N-butanoylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44548", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606602", "l": "ASAH1 hydrolyzes ceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341294", "l": "Superoxide reduces cytochrome c (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73596", "l": "dCMP + H2O => dUMP + NH4+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678920", "l": "TLR processing at low pH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38050", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71702", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) <=> H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10752", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.12", "l": "\"D-aspartate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10540", "l": "7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": [], "t": []}, {"i": "EC:4.1.2.25", "l": "\"dihydroneopterin aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445714", "l": "Aquaporin-3 passively transports water out of cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23317", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76662", "l": "butanal + H2O + NADP(+) <=> butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27280", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668978", "l": "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50400", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA = CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64227", "l": "AH2 + O2 + uridine(34) in tRNA <=> 5-hydroxyuridine(34) in tRNA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71011", "l": "L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13568", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol <=> 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019875", "l": "6-aminohexanoate-dimer hydrolase activity", "d": ["Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099621", "l": "undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity", "d": ["Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65075", "l": "(2E,6E)-farnesyl diphosphate <=> dauca-4,7-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69191", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12323", "l": "17-O-acetylnorajmaline + NADP(+) <=> 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213201", "l": "Formation of collagen fibres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693148", "l": "BCKDK phosphorylates BCKDH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34102", "l": "carboxynorspermidine + H(+) <=> CO2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704248", "l": "CHRM4 binds CHRM4 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002466", "l": "Formation of allysine by LOX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74357", "l": "a uridine in mRNA + NH4(+) => a cytidine in mRNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.69", "l": "\"monoterpenol O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047860", "l": "diiodophenylpyruvate reductase activity", "d": ["Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36942", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA <=> (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938913", "l": "RUNX1 binds ELF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24409", "l": "adenosine + H(+) + H2O => inosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047118", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity", "d": ["Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15512", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12386", "l": "H2O2 + uracil => 5,6-dihydrouracil + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080068", "l": "5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34615", "l": "2-hydroxyethylphosphonate + O2 = H(+) + hydrogencarbonate + methylphosphonate", "d": [], "t": []}, {"i": "EC:1.13.11.73", "l": "\"methylphosphonate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63913", "l": "6-azauridine + ATP => 6-azauridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49325", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-capsorubin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627106", "l": "SMAC (DIABLO) forms dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65169", "l": "AH2 + O2 + preaustinoid A => A + H2O + preaustinoid A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45859", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61327", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686930", "l": "RIPK3 is cleaved by CASP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102172", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351901", "l": "Caspase-mediated cleavage of MST3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14857", "l": "(indol-3-yl)acetate + ATP + L-lysine = ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.20", "l": "\"indoleacetate--lysine synthetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12102", "l": "H2O + microthecin => 1,5-anhydro-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64523", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA <=> A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32299", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663138", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CCRN4L (NOCTURNIN) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004572", "l": "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32676", "l": "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "50.038603763574663", "identifiers": [{"i": "GO:0022832", "l": "voltage-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432054", "l": "Aquaporin-1 passively transports water out of cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17002", "l": "amidinoproclavaminate + H2O => proclavaminate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43057", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH => 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088338", "l": "Defective GNE does not hydrolyse UDP-GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45820", "l": "mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate", "d": [], "t": []}, {"i": "EC:2.8.3.26", "l": "\"succinyl-CoA:mesaconate CoA transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20956", "l": "2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.30", "l": "\"phenylacetate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011543", "l": "DCA binds PDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66467", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> scalarane-17alpha-19-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656070", "l": "FGFBPs bind FGFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34993", "l": "L-arginine(in) + L-ornithine(out) => L-arginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036025", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49710", "l": "H(+) + isonocardicin C + S-methyl-5'-thioadenosine => nocardicin G + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0036080", "l": "purine nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22719", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76675", "l": "1-deoxysphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-1-deoxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759859", "l": "Expression of GATA4 in lateral plate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31338", "l": "CTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38875", "l": "uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.21", "l": "\"23S rRNA pseudouridine(2604) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033509", "l": "USP9X binds Ub:PEX5L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54962", "l": "AMP + dinor-OPDA-CoA + diphosphate => ATP + CoA + dinor-OPDA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390663", "l": "ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033882", "l": "choloyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45589", "l": "a long-chain fatty acid + ATP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636240", "l": "PPE2 binds NOS2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351341", "l": "Exocytosis of Proactivator polypeptide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10212", "l": "2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.48", "l": "\"5-aminovalerate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665410", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218811", "l": "DOCK180:ELMO binds CRK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30625", "l": "AH2 + all-trans-lycopene => A + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811508", "l": "ING2-bound EP300 acetylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15169", "l": "H2O + N-succinyl-L-glutamate = L-glutamate + succinate", "d": [], "t": []}, {"i": "EC:3.5.1.96", "l": "\"succinylglutamate desuccinylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46210", "l": "AMP + diphosphate + eicosanoyl-CoA => ATP + CoA + eicosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53130", "l": "epsilon-carotene => delta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68365", "l": "4-CDP-2-C-methyl-D-erythritol => 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693111", "l": "RHOF auto-activates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49796", "l": "an N-(fatty acyl)-glycine + H2O = a fatty acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757256", "l": "MCM3 binds MCM5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655823", "l": "Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23024", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.49", "l": "\"cellodextrin phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43562", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56180", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873946", "l": "OTUD3 deubiquitinates PTEN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63489", "l": "9,10-phenanthroquinone + H(+) + NADPH => NADP(+) + phenanthrene-9,10-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36832", "l": "2 caldariellaquinol + n H(+)(in) + O2 => 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868658", "l": "1,4-alpha-glucan is converted to glucanotrehalose (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20774", "l": "5-amino-6-(D-ribitylamino)uracil + riboflavin => 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017051", "l": "retinol dehydratase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51129", "l": "A + an aliphatic amine + H2O => AH2 + an aldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20541", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 = 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49043", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine <=> (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61442", "l": "CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine => acetyl-CoA + S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592398", "l": "Activation of proMMP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418091", "l": "F2R binds ARRB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749977", "l": "UGT1A6 glucuronates ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102099", "l": "FAD-dependent urate hydroxylase activity", "d": ["Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 = 5-hydroxyisouric acid + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51429", "l": "acetyl-CoA + aminomethylphosphonate => 2-N-acetamidomethylphosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428750", "l": "Gq activation by TP receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685011", "l": "ATR activation at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.23", "l": "\"S-methyl-5-thioribulose 1-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23033", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247836", "l": "Retromer recycles WLS to the Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607002", "l": "Activated protein C cleaves factor VIIIa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.46", "l": "\"memapsin 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20391", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+) => (2R,3R)-dihydroquercetin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18194", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73246", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether <=> cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58550", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67165", "l": "bromide + FADH2 + melleolide F + O2 => 6'-bromomelleolide F + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532632", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031694", "l": "alpha-2A adrenergic receptor binding", "d": ["Binding to an alpha-2A adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036046", "l": "Defective IDS does not hydrolyse Heparan sulfate chain(5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59124", "l": "(S)-2,3-diaminopropanoate + ATP + citrate = 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.3.2.54", "l": "\"L-2,3-diaminopropanoate--citrate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72380", "l": "chloride(out) + iodide(in) => chloride(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13759", "l": "(Z)-desulfoglucotropeolin + UDP => (Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53786", "l": "beta-muricholoyl-CoA + deoxycholate => beta-muricholate + deoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33934", "l": "all-trans-zeaxanthin + O2 <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23858", "l": "Hg(2+) + NADPH => H(+) + Hg + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873927", "l": "Release of STAT1 dimer from active receptor unit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36247", "l": "(E)-anol + S-adenosyl-L-methionine = (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43969", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050553", "l": "taxadiene synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5140741", "l": "WNT5A binds FZD and ROR receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620891", "l": "FOXO3 binds BTG1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69000", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine = 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.380", "l": "\"3-amino-4-hydroxybenzoate 4-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061712", "l": "tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase", "d": ["Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77441", "l": "a ganglioside GT1c + N-acetylneuraminate => a ganglioside GQ1c + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51861", "l": "(2E)-geranyl diphosphate + umbelliferone => 8-geranylumbelliferone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51528", "l": "H(+) + vanillate = CO2 + guaiacol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444511", "l": "Formation of MSH2:MSH3 Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937613", "l": "CRHBP binds CRH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211960", "l": "CYP2U1 19-hydroxylates ARA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71357", "l": "5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in) => 5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13029", "l": "H2O + N-acetyl-D-glucosamine + O2 = H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32127", "l": "2-oxoglutarate + L-proline + O2 = cis-4-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.56", "l": "\"L-proline cis-4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40970", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72330", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53921", "l": "ATP + L-threonyl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14760", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17621", "l": "acetyl-CoA + citramalate = (3S)-citramalyl-CoA + acetate", "d": [], "t": []}, {"i": "EC:2.8.3.11", "l": "\"citramalate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047811", "l": "D-alanine gamma-glutamyltransferase activity", "d": ["Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482772", "l": "Release of platelet cytosolic components (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37261", "l": "2-oxobutanoate + H(+) + NADH + NH4(+) => (2S)-2-aminobutanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58905", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH => C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65056", "l": "glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018707", "l": "1-phenanthrol methyltransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66687", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] <=> L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74533", "l": "2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol => AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047620", "l": "acylglycerol kinase activity", "d": ["Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863674", "l": "CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31654", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36527", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA = (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.18", "l": "\"1,4-alpha-glucan branching enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001790", "l": "polymeric immunoglobulin binding", "d": ["Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13924", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53350", "l": "H(+) + NADH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48785", "l": "D-erythrulose 4-phosphate => D-erythrose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18224", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629189", "l": "TP53 stimulates expression of SESN1,2,3 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45392", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470009", "l": "Phosphorylation of STATs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818574", "l": "TASP1 cleaves KMT2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0016624", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide."], "t": []}, {"i": "EC:1.2.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989747", "l": "Expression of FHL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803890", "l": "SFN dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56038", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.1", "l": "\"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.56", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654404", "l": "Activated FGFR2 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731057", "l": "SARS-CoV-1 3a binds to caspase-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74325", "l": "O-3-hydroxybutanoyl-(R)-carnitine(out) => O-3-hydroxybutanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390438", "l": "FAR2 reduces PalmCoA to HXOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19729", "l": "acetoacetate + H(+) = acetone + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.4", "l": "\"acetoacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051749", "l": "indole acetic acid carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015227", "l": "acyl carnitine transmembrane transporter activity", "d": ["Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane."], "t": []}, {"i": "REACT:R-HSA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45656", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16957", "l": "3',5'-cyclic GMP + H2O = GMP + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.35", "l": "\"3',5'-cyclic-GMP phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17785", "l": "H(+) + L-glutamate = 4-aminobutanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.15", "l": "\"glutamate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39696", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48878", "l": "L-seryl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392870", "l": "Gs activation by prostacyclin receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59790", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH => H2O + NAD(+) + pseudopaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33762", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH <=> a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836500", "l": "IKK complex is activated by PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28054", "l": "2-oxobutanoate + CoA = formate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53132", "l": "A + a 3-oxo-Delta(4)-steroid = a 3-oxo-Delta(1,4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.921857375477728", "identifiers": [{"i": "GO:0046915", "l": "transition metal ion transmembrane transporter activity", "d": ["Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804379", "l": "PRMT5 binds TTC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140282", "l": "carbon-nitrogen ligase activity on lipid II", "d": ["Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52569", "l": "epitestosterone + UDP-alpha-D-glucuronate => epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59305", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin => adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28709", "l": "Cd(2+)(out) => Cd(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199404", "l": "CD40L binds CD40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41400", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45854", "l": "Co(II)-factor IV + S-adenosyl-L-homocysteine => Co(II)-factor III + H(+) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674529", "l": "AAMP binds to TBXA2R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110218", "l": "Cleavage of uracil by TDG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627106", "l": "SMAC (DIABLO) forms dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940561", "l": "MMP7 cleaves OPTC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430308", "l": "PARVB interacts with Alpha-actinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61296", "l": "5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937419", "l": "CBR3 reduces DOX to DOXOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799416", "l": "TP53 stimulates expression of TP53INP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888577", "l": "Synthesis of GABA by GAD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1878002", "l": "XYLTs transfer Xyl to core protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-555065", "l": "Formation of clathrin coated vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25302", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.67", "l": "\"dihydroneopterin triphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928639", "l": "p-EFNB binds GRB4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63548", "l": "angiotensin-(1-9) + H2O = angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047202", "l": "sinapoylglucose-choline O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11644", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45201", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45773", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate => [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761844", "l": "NFE2L2-dependent IDH1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23950", "l": "H(+) + NADH + succinate semialdehyde => 4-hydroxybutanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22004", "l": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031873", "l": "type 2 proteinase activated receptor binding", "d": ["Binding to a type 2 proteinase activated receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004400", "l": "histidinol-phosphate transaminase activity", "d": ["Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11990", "l": "1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56668", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.116", "l": "\"7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36230", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56072", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose = a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.358", "l": "\"acylphloroglucinol glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20164", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose <=> myo-inositol + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047315", "l": "kynurenine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67094", "l": "ADP + docosanoate(out) + H(+) + phosphate => ATP + docosanoate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47906", "l": "ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate => ATP + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182243", "l": "Formation of MHC I:Nef Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42716", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.9.1.3", "l": "\"tRNA 2-selenouridine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38563", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909720", "l": "IFN alpha/beta binds to IFNAR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876446", "l": "p-ULK1 phosphorylates DENND3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0001640", "l": "adenylate cyclase inhibiting G protein-coupled glutamate receptor activity", "d": ["Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034211", "l": "GTP-dependent protein kinase activity", "d": ["GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928625", "l": "PAKs autophosphorylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39725", "l": "a 1,2-diacyl-sn-glycerol(out) => a 1,2-diacyl-sn-glycerol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31122", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621370", "l": "SYK autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167474", "l": "Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0023026", "l": "MHC class II protein complex binding", "d": ["Binding to a class II major histocompatibility complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36364", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH => (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20060", "l": "2 H(+) + H2O + N-carbamoylsarcosine <=> CO2 + NH4(+) + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70856", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) => L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050396", "l": "vomifoliol 4'-dehydrogenase activity", "d": ["Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD+ = (6S)-6-hydroxy-3-oxo-alpha-ionone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696997", "l": "USP24 deubiquitinates DDB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39200", "l": "(3R)-hydroxytetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-114284", "l": "Release of Cytochrome c from mitochondria (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018795", "l": "2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199093", "l": "CXADR binds to AMICA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51600", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821941", "l": "BOD1 binds SET1B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939335", "l": "RNF181 polyubiquinates BCL10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77563", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-(9Z-octadecenoyl)-3-hexadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388468", "l": "AVP(20-28) binds AVPR1A,B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004951", "l": "cholecystokinin receptor activity", "d": ["Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759189", "l": "NFE2L2-dependent PRDX1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56124", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O = AH2 + diphosphate + nonaflavuxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3782655", "l": "HDAC10 deacetylates histone (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58170", "l": "(-)-5-epi-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27783", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate => 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944454", "l": "mTORC1 phosphorylates MAF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44303", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023941", "l": "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55369", "l": "(R)-carnitine + H(+) + NADPH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72232", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) => chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46556", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 = 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9648268", "l": "HTR1A binds HTR1A antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42674", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => gamma-L-glutamyl-L-cysteine + hercynine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141423", "l": "Binding of the MCC complex to the APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22658", "l": "CMP + H(+) + L-serine-phosphoethanolamine => CDP-ethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835385", "l": "DUS2 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59207", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209823", "l": "Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938356", "l": "RMB14 binds RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41641", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749590", "l": "ASA- acetylates ALB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70108", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide => H(+) + penilactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205319", "l": "Interaction of APS and p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004342", "l": "glucosamine-6-phosphate deaminase activity", "d": ["Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67204", "l": "H2O + N-acetyltryptamine = acetate + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626928", "l": "CREBBP binds FOXO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875374", "l": "MET binds LRIG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45867", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193641", "l": "IKK-beta is recruited (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51690", "l": "H(+) + keto-L-tagatose + NADH => galactitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18275", "l": "4-aminobutanal + H2O2 + NH4(+) => H2O + O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61916", "l": "ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047762", "l": "caffeate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: trans-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72984", "l": "dimethylallyl diphosphate + harmol => 6-(3-dimethylallyl)harmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35181", "l": "7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone => 6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74940", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 => a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68263", "l": "D-serine(in) + Na(+)(in) <=> D-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433418", "l": "Phosphorylation of JAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22984", "l": "carbamoyl phosphate + oxamate = N-carbamoyl-2-oxoglycine + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.5", "l": "\"oxamate carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27522", "l": "2,5-dihydroxypyridine + O2 = H(+) + N-formylmaleamate", "d": [], "t": []}, {"i": "EC:1.13.11.9", "l": "\"2,5-dihydroxypyridine 5,6-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0098599", "l": "palmitoyl hydrolase activity", "d": ["Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45150", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-(methylsulfanyl)acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71565", "l": "5-acetylaminomethyl-dUMP in DNA + CoA + H(+) => 5-aminomethyl-dUMP in DNA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75079", "l": "Formation of AT-AC C complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72107", "l": "Na(+)(out) + O-acyl-(R)-carnitine(out) = Na(+)(in) + O-acyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74972", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) => L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000433", "l": "SUMOylation of PML with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18066", "l": "ATP + H2O + phosphonate(out) => ADP + H(+) + phosphate + phosphonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130706", "l": "MHC class II antigen processing (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.13", "l": "\"L-methionine (S)-S-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247960", "l": "Activation of p38 MAPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73865", "l": "Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0019202", "l": "amino acid kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864569", "l": "WWOX binds TFAP2C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047305", "l": "(R)-3-amino-2-methylpropionate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72375", "l": "hydrogencarbonate(out) + iodide(in) = hydrogencarbonate(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857555", "l": "EGFR phosphorylates GPNMB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0046923", "l": "ER retention sequence binding", "d": ["Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16034", "l": "2-oxoglutarate + gibberellin A44 + O2 => CO2 + gibberellin A19 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57816", "l": "dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236968", "l": "Egress of internalized antigen into cytosol from early endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010490", "l": "UDP-4-keto-rhamnose-4-keto-reductase activity", "d": ["Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181567", "l": "botC LC cleaves target cell STX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77663", "l": "1-O-alkyl-3-acylglycerol + an acyl-CoA = 1-O-alkyl-2,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16856", "l": "N(6)-(1,2-dicarboxyethyl)-AMP <=> AMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13251", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (R)-2-hydroxypropyl-coenzyme M + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.87", "l": "\"endo-cleaving rubber dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138432", "l": "DVL2 is phosphorylated by PKC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788867", "l": "FN3K phosphorylates ketosamines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090587", "l": "protein-phosphocysteine-glucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55885", "l": "[aequorin] + 3 Ca(2+) => [aequorin]--dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10113", "l": "L-homocysteine + L-serine => H2O + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70630", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189406", "l": "4 PBGs bind to form HMB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016987", "l": "sigma factor activity", "d": ["Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.241", "l": "\"Kdo2-lipid IVA acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481010", "l": "Surface deployment of platelet dense granule membrane components (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051879", "l": "Hsp90 protein binding", "d": ["Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868573", "l": "CDK5:p25 phosphorylates PRDX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75580", "l": "A + cyathatriol => AH2 + cyathin A3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41367", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33296", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43952", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28106", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-D-tagatose 6-phosphate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.251", "l": "\"galactitol-1-phosphate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592240", "l": "Formation of NRF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61614", "l": "7-epi-cylindrospermopsin + CO2 + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928646", "l": "EPHAs bind EFNAs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24307", "l": "glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] <=> CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416683", "l": "SEMA3E binds to PLXND1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17349", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.146", "l": "\"3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29268", "l": "L-valine(in) + Na(+)(in) => L-valine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77747", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacylglycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450088", "l": "GLUT1 tetramer binds 4xATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084912", "l": "Arresten binds integrin alpha1beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10348", "l": "5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:3.5.2.9", "l": "\"5-oxoprolinase (ATP-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013435", "l": "RHOD auto-activates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13772", "l": "glycerol + NAD(+) <=> dihydroxyacetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654625", "l": "Activated FGFR3 binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25466", "l": "diphosphate + longifolene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794444", "l": "ALB binds Cipro (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692755", "l": "CDK1 phosphorylates MAPK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45582", "l": "D-galactaro-1,4-lactone => D-galactaro-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74163", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5099899", "l": "WNT5A binds FZD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44876", "l": "a 1,3-diacylglycerol + H2O = a 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444523", "l": "Formation of MSH1:PMS2 Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102906", "l": "7-epi-alpha-selinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = (-)-7-epi-alpha-selinene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062188", "l": "anandamide 11,12 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:53144", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047933", "l": "glucose-1,6-bisphosphate synthase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938356", "l": "RMB14 binds RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21061", "l": "3,4-dichloroaniline + malonyl-CoA => CoA + N-(3,4-dichlorophenyl)malonamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54259", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37501", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850945", "l": "Casein kinase II phosphorylates PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434990", "l": "SEMA7A binds to integrin alpha1beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44892", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose = an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45588", "l": "a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.20", "l": "\"long-chain-fatty-acid--[acyl-carrier-protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48714", "l": "2 Fe(3+) + 2 H2O => 2 Fe(2+) + 2 H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953111", "l": "E2F6 binds TFDP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218847", "l": "PAK2 binds NCK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17842", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76728", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 7-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052903", "l": "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54584", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30861", "l": "dIDP + H(+) + phosphate => dITP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56743", "l": "a globoside Gb3Cer + UDP-alpha-D-galactose <=> a globoside GalGb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50282", "l": "(5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63884", "l": "H2O2 + L-tyrosine = H2O + L-dopa", "d": [], "t": []}, {"i": "EC:1.11.2.6", "l": "\"L-tyrosine peroxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68721", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047091", "l": "L-lysine 6-monooxygenase (NADPH) activity", "d": ["Catalysis of the reaction: L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51996", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56760", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27609", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806974", "l": "MET dimers autophosphorylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46002", "l": "1-tuberculosinyladenosine + diphosphate => adenosine + H(+) + tuberculosinyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001733", "l": "galactosylceramide sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72730", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) <=> UDP-alpha-D-glucuronate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51999", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37524", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18840", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA <=> CoA + taxuyunnanin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43017", "l": "an S-alkyl-L-cysteine => 2-aminoprop-2-enoate + an alkyl thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005144", "l": "interleukin-13 receptor binding", "d": ["Binding to an interleukin-13 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170965", "l": "(Frs2)Rap1-GTP binds to and activates B-Raf (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19212", "l": "codeine + NADP(+) <=> codeinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38574", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49586", "l": "L-erythrulose 1-phosphate => D-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56401", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202394", "l": "Translocation of CARMA1 to Plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34618", "l": "2-hydroxyethylphosphonate + O2 <=> H(+) + hydrogencarbonate + methylphosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72946", "l": "2 Na(+)(out) + pyruvate(out) <=> 2 Na(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37142", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.28", "l": "\"acrocylindropepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203774", "l": "Interaction of Csk with PAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821931", "l": "BOD1L1 binds SET1A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0003978", "l": "UDP-glucose 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-glucose = UDP-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65390", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15144", "l": "4-methylphenol + H2O + 4 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939204", "l": "ESTG binds ESR1:chaperone complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57385", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102195", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP = UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77718", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59062", "l": "(20S)-ginsenoside Rh2 + D-glucose => (20S)-ginsenoside Rg3 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613497", "l": "Unwinding DNA for the nascent transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852010", "l": "BTNL2 binds activated T cells surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839146", "l": "YME1L1 degrades mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0042625", "l": "ATPase-coupled ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19822", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008822", "l": "PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730836", "l": "Interaction of BCL10:MALT1 with CARMA1 to form CBM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48904", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11065", "l": "beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16212", "l": "Co-precorrin-8X <=> cob(II)yrinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37429", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13871", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADH => NAD(+) + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981622", "l": "Myoglobin:oxygen dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68896", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH = 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43393", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60063", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15801", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25353", "l": "H(+) + L-cysteine + tRNA(Pro) => H2O + L-cysteinyl-tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53382", "l": "H(+) + NADH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38299", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835189", "l": "NCK1 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49942", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008901", "l": "ferredoxin hydrogenase activity", "d": ["Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.201143870267188", "identifiers": [{"i": "GO:0016780", "l": "phosphotransferase activity, for other substituted phosphate groups", "d": ["Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186765", "l": "PLC-gamma binds to the active receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34138", "l": "cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51008", "l": "2 Fe(III)-[cytochrome cL] + methanol = 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44574", "l": "2-all-trans-heptaprenylphenol + CO2 => 4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70422", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O <=> 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67179", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite <=> H(+) + methanol + O13(4)-desmethyl pFDCC", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035487", "l": "thymine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a T/T mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0019888", "l": "protein phosphatase regulator activity", "d": ["Binds to and modulates the activity of a protein phosphatase."], "t": []}, {"i": "REACT:R-HSA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68973", "l": "A + sn-glycerol 3-phosphate => AH2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871227", "l": "RET binds GFRA4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419861", "l": "Melanospin is stimulated by light (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667111", "l": "PARK2 K63-Ubiquitinates SNCAIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164521", "l": "Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265301", "l": "Corticotropin cleavage from POMC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70583", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28022", "l": "ATP + holo-[ACP] + octanoate = AMP + diphosphate + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58448", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749590", "l": "ASA- acetylates ALB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.34709754747162", "identifiers": [{"i": "GO:0015297", "l": "antiporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174235", "l": "Association of Emi1 with Cdc20 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0050115", "l": "myosin-light-chain-phosphatase activity", "d": ["Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18953", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23997", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70983", "l": "glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73036", "l": "Co(2+)(out) + H(+)(out) => Co(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71590", "l": "(S)-malate(in) + 2-oxoglutarate(out) <=> (S)-malate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949687", "l": "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592387", "l": "Fibulin binds elastic fibres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099635", "l": "voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels", "d": ["Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission."], "t": []}, {"i": "REACT:R-HSA-9659515", "l": "CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23093", "l": "H(+) + H2O + hydroxyatrazine => ethylamine + N-isopropylammelide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25189", "l": "chloroacetate + H2O = chloride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110463", "l": "Increased PIP3 levels recruit DAkt1 to the membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034840", "l": "3-hydroxymenthone dehydrogenase activity", "d": ["Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28199", "l": "(S)-1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46821", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22212", "l": "(2R,3R)-tartrate = (2R,3S)-tartrate", "d": [], "t": []}, {"i": "EC:5.1.2.5", "l": "\"tartrate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77697", "l": "a ganglioside GM1alpha (d18:1(4E)) + CMP + H(+) => a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879311", "l": "mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62255", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) <=> 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102882", "l": "beta-acoradiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-acoradiene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638104", "l": "UGCG transfers glucose to ceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196929", "l": "FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9675026", "l": "Formation of the MLL1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43960", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66312", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O = a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917700", "l": "MVB Vesicle Formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61823", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose <=> epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046555", "l": "acetylxylan esterase activity", "d": ["Catalysis of the deacetylation of xylans and xylo-oligosaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661230", "l": "MT1A binds arsenic (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664879", "l": "ATM:PEX5 binds ATM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18308", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-4-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48566", "l": "D-ribose 5-phosphate + trans-zeatin => 9-ribosyl-trans-zeatin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61157", "l": "3'-dephospho-CoA + GTP => CoA + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373748", "l": "SEMA4D interacts with CD72 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63146", "l": "(15Z)-tetracosenoate + ethanolamine => H2O + N-(15Z-tetracosenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0034318", "l": "alcohol O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432010", "l": "Aquaporin-1 passively transports water into cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55327", "l": "11-cis-retinol + hexadecanoyl-CoA <=> 11-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180709", "l": "Association of multimerized Rev with beta-importin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51411", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35954", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate <=> diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74566", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate <=> aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14000", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37046", "l": "ATP + H2O + L-alanyl-L-glutamate(out) <=> ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43382", "l": "L-arginyl-[protein] + phosphate => H2O + N(omega)-phospho-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681294", "l": "IL6R binds IL6R inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33931", "l": "all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}, {"i": "EC:1.13.11.65", "l": "\"carotenoid isomerooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761170", "l": "Expression of PAX2 in intermediate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015529", "l": "raffinose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103061", "l": "trans-methoxy-C60-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] = diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28658", "l": "glutathione S,S-dioxide + H2O <=> glutathione + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014293", "l": "RAC2 GDIs block activation of RAC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36605", "l": "(3S)-3-hydroxy-L-enduracididine + CO2 + succinate => 2-oxoglutarate + L-enduracididine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68705", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) => 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73195", "l": "malonate(in) + sulfate(out) = malonate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51702", "l": "4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthogalenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69768", "l": "(E)-non-2-enal + H2O + NAD(+) => (E)-non-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34590", "l": "2-oxoglutarate + O2 + pentalenolactone E <=> CO2 + pentalenolactone F + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.700960687975609", "identifiers": [{"i": "GO:0036361", "l": "racemase activity, acting on amino acids and derivatives", "d": ["Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13275", "l": "6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25976", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668735", "l": "RAC1:GTP binds NOX3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73323", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA = cimicifugate D + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213241", "l": "Formation of nonameric complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65090", "l": "asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane E + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.21", "l": "\"aldose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40395", "l": "1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607746", "l": "PKC-delta is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031828", "l": "type 2C serotonin receptor binding", "d": ["Binding to a type 2C serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34229", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite => 5-nitrosalicylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10989", "l": "H2O + nitrous oxide => 2 e(-) + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102716", "l": "gibberellin A28,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 = (2betaOH)-gibberellin28 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467466", "l": "ABCA4 mediates atRAL transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0044013", "l": "histone H2B acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55756", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 = a 2-hydroxyornithine lipid + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.58", "l": "\"ornithine lipid ester-linked acyl 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913374", "l": "Phosphorylated SHC1 recruits SHIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16678", "l": "fluoroacetaldehyde + H2O + NAD(+) => fluoroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667965", "l": "ANKLE2 binds PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47943", "l": "a ganglioside GM2 (d18:1(4E)) + H2O <=> a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72155", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44160", "l": "1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29208", "l": "a menaquinol(in) + dimethyl sulfoxide(out) => a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707523", "l": "Hemes bind to BACH1:MAFK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37779", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19302", "l": "histamine + S-adenosyl-L-methionine => H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179417", "l": "Multiubiquitination of Nek2A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54421", "l": "3',3'-c-di-AMP + H2O => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210913", "l": "NEUROG3-dependent synthesis of INSM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102778", "l": "delta9-tetrahydrocannabinolate synthase activity", "d": ["Catalysis of the reaction: cannabigerolate + O2 = delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052625", "l": "4-aminobenzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47379", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70028", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45880", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32249", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38007", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25550", "l": "abieta-8(14),12-diene + diphosphate => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69068", "l": "RFC dissociates after sliding clamp formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36029", "l": "H(+) + NADH + propanoyl-CoA => CoA + NAD(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49069", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76876", "l": "H2O + hexan-2-amine + NAD(+) => H(+) + hexan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43182", "l": "5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951644", "l": "Release of mature NEDD8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68330", "l": "(R)-pantetheine + phosphate => (R)-4'-phosphopantetheine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32616", "l": "(6E)-8-oxogeraniol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21569", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086083", "l": "SUMOylation of ING2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34525", "l": "[alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57148", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17404", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66940", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine = 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74518", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B <=> aspoquinolone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34095", "l": "carboxyspermidine + H(+) = CO2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24449", "l": "enterobactin + UDP-alpha-D-glucose => monoglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73730", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate <=> (2S,3R,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16532", "l": "ADP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67540", "l": "(9Z)-hexadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050613", "l": "delta14-sterol reductase activity", "d": ["Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44464", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71784", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) => 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63945", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine => an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042835", "l": "BRE binding", "d": ["Binding to a BRE RNA element (Bruno response element)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140474", "l": "mitochondrion-endoplasmic reticulum membrane tether activity", "d": ["The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391942", "l": "IP receptor can bind prostacyclin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27449", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.75", "l": "\"diacylglycerol diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955893", "l": "SOCS4 gene expression is inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29379", "l": "dGMP + H2O = 2'-deoxyguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62266", "l": "hydrogencarbonate(in) + selenite(in) + Zn(2+)(in) => hydrogencarbonate(out) + selenite(out) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34508", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate => N,N-diacetyllegionaminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156910", "l": "Formation of eEF1B complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31437", "l": "(+)-alpha-santalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56847", "l": "nocamycin E + S-adenosyl-L-methionine <=> nocamycin I + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140945", "l": "histone H3K4 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380200", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15292", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose <=> [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709317", "l": "CO binds to free ferrohemoglobin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17469", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": [], "t": []}, {"i": "EC:2.3.1.135", "l": "\"phosphatidylcholine--retinol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857336", "l": "CEBPB homodimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43704", "l": "ATP + H(+) + tetradecanoate = diphosphate + tetradecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.391", "l": "\"beta-1,2-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75902", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O <=> 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444208", "l": "MLNR (GPR38) is a receptor for motilin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0019120", "l": "hydrolase activity, acting on acid halide bonds, in C-halide compounds", "d": ["Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.14", "l": "\"nocardicin-A epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9656891", "l": "OPN1SW binds 11cRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64940", "l": "dGDP + H2O = dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47900", "l": "a ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64340", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one = 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9834807", "l": "ILF3 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156930", "l": "GTP-binding activates eEF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688834", "l": "ATXN3 binds VCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59905", "l": "H2O + NADP(+) + octanal => 2 H(+) + NADPH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218812", "l": "FYN phosphorylates PAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36336", "l": "D-glucuronate + H2O + NAD(+) => D-glucarate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54777", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047412", "l": "N-(long-chain-acyl)ethanolamine deacylase activity", "d": ["Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25854", "l": "an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53755", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47575", "l": "a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354097", "l": "Activation of Talin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018829", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19211", "l": "codeinone + H(+) + NADPH => codeine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50380", "l": "3 H(+) + 3 malonyl-CoA = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.253", "l": "\"phloroglucinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.59917137531788", "identifiers": [{"i": "GO:0001217", "l": "DNA-binding transcription repressor activity", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190520", "l": "Association of Golgi  transport vesicles with microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37095", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74733", "l": "Insulin receptor de-phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40634", "l": "H2O + trioctadecanoylglycerol <=> 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034017", "l": "trans-2-decenoyl-acyl-carrier-protein isomerase activity", "d": ["Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60147", "l": "ATP + L-glutamate + L-glutamyl-[protein] <=> ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60521", "l": "2 H2O + L-cystine-bis-glycine => 2 glycine + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51352", "l": "H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43122", "l": "CO2 + succinate + urate => 2-oxoglutarate + O2 + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33336", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786155", "l": "POLN binds ICL-DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865320", "l": "CBFB binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17736", "l": "acetylenedicarboxylate + H(+) + H2O <=> CO2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112755", "l": "SOCS3 binds IL6ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008568", "l": "microtubule severing ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570528", "l": "SUMOylation of XPC with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694421", "l": "PP6 dephosphorylates SEC24 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21909", "l": "NADP(+) + scytalone => H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10849", "l": "an [alpha-factor](in) + ATP + H2O => ADP + an [alpha-factor](out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41718", "l": "a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine => a 2-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33910", "l": "4-(methylamino)butanoate + H2O + O2 <=> 4-aminobutanoate + formaldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49321", "l": "all-trans-violaxanthin => (5R,6S)-5,6-epoxi-capsanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388814", "l": "Grb2 binds CD28 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45679", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5622129", "l": "FABP5 binds atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66792", "l": "N-methyl-D-dopa + O2 = (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782637", "l": "HDAC8 deacetylates histones (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31990", "l": "(S)-2,3-epoxysqualene <=> baruol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69074", "l": "Formation of Processive Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55412", "l": "[phosphate](n) + GTP = [phosphate](n+1) + GDP", "d": [], "t": []}, {"i": "EC:2.7.4.34", "l": "\"GDP-polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71735", "l": "formyl-CoA + succinate = formate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31378", "l": "H(+) + pyrrole-2-carboxylate <=> 1H-pyrrole + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0051032", "l": "nucleic acid transmembrane transporter activity", "d": ["Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390649", "l": "CHRM1,3,5 bind acetylcholine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871260", "l": "YAP1 binds TEAD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19810", "l": "(S)-ureidoglycolate + 2 H(+) + H2O => CO2 + glyoxylate + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166041", "l": "Transfer of LPS onto TLR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106063", "l": "G protein-coupled folate receptor activity", "d": ["Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28647", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate = 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.8", "l": "\"acetophenone carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37518", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58787", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 <=> a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47034", "l": "2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134953", "l": "DHX36 or DHX9 binds MyD88 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63405", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 => 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624158", "l": "Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31381", "l": "1H-pyrrole + hydrogencarbonate => H2O + pyrrole-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41004", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28415", "l": "gamma-L-glutamylputrescine + H2O + O2 => 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66169", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O => [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25318", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693125", "l": "RHOF binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30052", "l": "fluoroacetate + H2O => fluoride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008109", "l": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45487", "l": "H(+) + pyruvate <=> acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35250", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917730", "l": "Cargo Recognition And Sorting (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944219", "l": "Association of procollagen type XVI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14142", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26168", "l": "3-fumarylpyruvate + H2O = fumarate + H(+) + pyruvate", "d": [], "t": []}, {"i": "EC:3.7.1.20", "l": "\"3-fumarylpyruvate hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73474", "l": "D-ornithine(in) + L-ornithine(out) <=> D-ornithine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251942", "l": "Hikeshi binds HSP70s:ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611721", "l": "β1-agonists bind ADRB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75704", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043836", "l": "xanthine hydrolase activity", "d": ["Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18883", "l": "ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate => ATP + histamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23920", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46116", "l": "2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36150", "l": "acetyl-CoA + benzyl alcohol <=> benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20664", "l": "D-alanyl-D-alanine + H2O <=> 2 D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4085992", "l": "SUMOylation of DAXX with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174551", "l": "Formation of alternative pathway C5 convertase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696960", "l": "USP49 deubiquitinates H2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22032", "l": "3-oxalomalate = glyoxylate + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.1.3.13", "l": "\"oxalomalate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18352", "l": "ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61165", "l": "kaempferol + UDP-beta-L-rhamnose => H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71356", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) => 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57909", "l": "ATP + L-glutamyl-tRNA(Gln) => 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18359", "l": "H(+) + NADPH + tropinone => NADP(+) + tropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19330", "l": "nuatigenin + UDP-alpha-D-glucose => H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31185", "l": "3-oxododecanoyl-CoA + CoA => acetyl-CoA + decanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50450", "l": "A + H2O + prostaglandin H3 => AH2 + prostaglandin G3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38343", "l": "(20S)-ginsenoside Rd + H2O = (20S)-ginsenoside Rg3 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34258", "l": "sporulenol <=> (R)-tetraprenyl-beta-curcumene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73199", "l": "maleate(in) + sulfate(out) = maleate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55526", "l": "3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696491", "l": "CNTF binds CNTFR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24033", "l": "sucrose => 6-O-alpha-D-glucopyranosyl-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008941", "l": "nitric oxide dioxygenase NAD(P)H activity", "d": ["Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40911", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32240", "l": "gamma-carotene => all-trans-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220957", "l": "NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218832", "l": "CDC42:GTP binds PAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63610", "l": "apelin-16 + L-phenylalanine => apelin-17 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34533", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806831", "l": "CYB5Rs reduce MetHb to HbA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58651", "l": "rifamycin SV hemiaminal <=> H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549322", "l": "OCT1 transports organic cations out of hepatic cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60133", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008116", "l": "prostaglandin-I synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44698", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420243", "l": "GHRH receptor binds GHRH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.1", "l": "\"proteasome endopeptidase complex\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4411373", "l": "NLK translocates to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001642", "l": "group III metabotropic glutamate receptor activity", "d": ["A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14788", "l": "RNA(n) + UTP <=> diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16990", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043822", "l": "ribonuclease M5 activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66429", "l": "D-arabinose(out) + H(+)(out) => D-arabinose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75594", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043834", "l": "trimethylamine methyltransferase activity", "d": ["Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800253", "l": "TP53 binds the BCL6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1471322", "l": "Beta-defensins are secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018807", "l": "RAC3 GDIs block activation of RAC3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035717", "l": "chemokine (C-C motif) ligand 7 binding", "d": ["Binding to chemokine (C-C motif) ligand 7."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029456", "l": "RAC1 and CDC42 activate PAK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684836", "l": "CLEC1B dimer binds PDPN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050546", "l": "4-hydroxyphenylpyruvate decarboxylase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H+ = (4-hydroxyphenyl)acetaldehyde + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651992", "l": "PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31601", "l": "(Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2059926", "l": "NPHP4 protein binds LATS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32541", "l": "(+)-car-3-ene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450088", "l": "GLUT1 tetramer binds 4xATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35234", "l": "rifampicin(in) <=> rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52853", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] => 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37087", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618405", "l": "ARL4C mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53492", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": [], "t": []}, {"i": "EC:2.1.1.86", "l": "\"tetrahydromethanopterin S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63398", "l": "AH2 + Fe(II)-hydroxyheme i => A + Fe(II)-heme i + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35656", "l": "2 ATP => 3',3'-c-di-AMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51346", "l": "8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39838", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73105", "l": "luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => diosmetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77039", "l": "4-hydroxyhexan-3-amine + H2O + NAD(+) = 4-hydroxyhexan-3-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.161717068681156", "identifiers": [{"i": "GO:0008094", "l": "ATP-dependent activity, acting on DNA", "d": ["Catalytic activity that acts to modify DNA, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210290", "l": "Interaction of PECAM-1 and SHIP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690494", "l": "RHOB translocates to the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73409", "l": "(S,S)-tartrate(out) + sulfate(in) => (S,S)-tartrate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031695", "l": "alpha-2B adrenergic receptor binding", "d": ["Binding to an alpha-2B adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174119", "l": "Free APC/C phosphorylated by Plk1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34829", "l": "H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+) => H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67707", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.200", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45833", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683622", "l": "mRNA5 is translated to protein M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34464", "l": "8-hydroxycopalyl diphosphate => cis-abienol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37967", "l": "galactitol + NADP(+) = D-galactose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48940", "l": "an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid", "d": [], "t": []}, {"i": "EC:3.4.13.19", "l": "\"membrane dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64959", "l": "dTTP + 2 H2O <=> dTMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73002", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] <=> L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.49", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004311", "l": "farnesyltranstransferase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392749", "l": "Transport of L1 into endosomes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62579", "l": "ATP + H2O + L-cystine(out) <=> ADP + H(+) + L-cystine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050018", "l": "L-amino-acid dehydrogenase activity", "d": ["Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30251", "l": "2 a ubiquinol + n H(+)(in) + O2 = 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}, {"i": "EC:7.1.1.3", "l": "\"ubiquinol oxidase (H(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16680", "l": "fluoroacetaldehyde + H2O + NAD(+) <=> fluoroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74726", "l": "Dissociation of insulin from insulin receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036209", "l": "9beta-pimara-7,15-diene oxidase activity", "d": ["Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32682", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geraniol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47761", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004918", "l": "interleukin-8 receptor activity", "d": ["Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866269", "l": "ARRB bind GPCRs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18410", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42429", "l": "clavaminate => (3R,5R)-clavulanate-9-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60319", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52128", "l": "a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28073", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b <=> diphosphate + Fe(II)-heme o", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226979", "l": "ADD1:ADD2 binds DMTN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76809", "l": "(3S)-1-hydroxy-3-methylpentan-2-one + H(+) + NADH + NH4(+) => (S)-isoleucinol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11453", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.21", "l": "\"cholesterol 7-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853745", "l": "RET binds GFRA1,GFRA3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868783", "l": "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76052", "l": "Binding of TFIIIA To type 1 Promoter (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61340", "l": "(S)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16282", "l": "ATP + dihydrostreptomycin 6-phosphate => ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41810", "l": "(2E)-butenoyl-[ACP] + H2O => (3R)-hydroxybutanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712078", "l": "ALK mutants bind PI3KR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13030", "l": "H2O + N-acetyl-D-glucosamine + O2 => H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66589", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14829", "l": "hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine", "d": [], "t": []}, {"i": "EC:2.5.1.47", "l": "\"cysteine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21239", "l": "anthranilate + 2 H(+) + NADPH + O2 <=> 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44316", "l": "1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51574", "l": "(25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045237", "l": "CXCR1 chemokine receptor binding", "d": ["Binding to a CXCR1 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46778", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879358", "l": "AGER-1,2,3 bind AGEs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52252", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44130", "l": "CoA + hexadecanyl (9E)-octadecenoate => (9E)-octadecenoyl-CoA + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71664", "l": "a menaquinone + 2 H(+)(out) + succinate => a menaquinol + fumarate + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029453", "l": "Phosphorylation of VAV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43266", "l": "1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13450", "l": "2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70360", "l": "3-oxosphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42039", "l": "chenodeoxycholate + NAD(+) <=> 7-oxolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21690", "l": "an oxidized polyvinyl alcohol + n H2O2 => a polyvinyl alcohol + n O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944265", "l": "Association of procollagen type IV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687724", "l": "GSK3B binds GSKi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043807", "l": "3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36557", "l": "CoA + H(+) + N-eicosanoylsphinganine => eicosanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75562", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] <=> cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140142", "l": "nucleocytoplasmic carrier activity", "d": ["Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58067", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin <=> 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863472", "l": "DAB2 binds LRP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54264", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61658", "l": "(2E,6E)-farnesyl phosphate + ADP + H(+) => (2E,6E)-farnesol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32917", "l": "sn-glycero-3-phospho-1D-myo-inositol(in) => sn-glycero-3-phospho-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24851", "l": "3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624948", "l": "KIF17 enters the cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65391", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37590", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981621", "l": "Neuroglobin:oxygen dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707683", "l": "PGRMC2 binds Hemes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382057", "l": "Release of novel PDGFs as latent factors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52241", "l": "2 H2O + 2 Mn(2+) + O2 => 4 H(+) + 2 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112037", "l": "Inactivation of PLC beta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71309", "l": "chloride(in) + L-valine(in) + 2 Na(+)(in) => chloride(out) + L-valine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454916", "l": "The ABCC family mediates organic anion transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042934", "l": "achromobactin transmembrane transporter activity", "d": ["Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71467", "l": "H2O + substance P = L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57698", "l": "adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)inamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69724", "l": "(indol-3-yl)acetyl-AMP + CoA => (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11549", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51571", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75753", "l": "10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.109", "l": "\"matriptase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47441", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) => 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156678", "l": "Activation of Cdc25C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16567", "l": "3-(imidazol-5-yl)pyruvate + L-glutamate => 2-oxoglutarate + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45108", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0097363", "l": "protein O-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0051427", "l": "hormone receptor binding", "d": ["Binding to a receptor for a hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12022", "l": "a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67556", "l": "3'-phosphoadenylyl sulfate + glycocholate = adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264622", "l": "Cho is acetylated to AcCho by CHAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75473", "l": "thiamine diphosphate(in) => thiamine diphosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52299", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050223", "l": "protocatechuate decarboxylase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzoate + H+ = catechol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28220", "l": "H2O + hypochlorous acid => chloride + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64614", "l": "AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15155", "l": "4-(beta-D-glucosyloxy)benzoate + H(+) + UDP => 4-hydroxybenzoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57003", "l": "acetyl-CoA + streptothricin F <=> CoA + H(+) + N(beta)-acetylstreptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30316", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 => 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429767", "l": "Passive I- efflux mediated by SMCT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5195402", "l": "CDK1 phosphorylates LPIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604368", "l": "Autocatalytic activation of bound proMMP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52260", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c = a bacteriochlorophyllide e + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41871", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59340", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A = 1'-hydroxy-demethylspheroidene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39907", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.106", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62635", "l": "a hydroperoxide + 2 glutathione <=> an alcohol + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832006", "l": "Nascent M2-1 binds Zn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30020", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + lipid A-core", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660666", "l": "CBP and p300 binds NF-kB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15960", "l": "D-altronate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23167", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose <=> a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42623", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O <=> (Z)-2-methylaminoacrylate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796053", "l": "PRKCI phosphorylates NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74094", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30630", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22579", "l": "an N-acyl-L-homoserine lactone + H2O <=> an N-acyl-L-homoserine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13783", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => an L-alpha-amino acid + H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140758", "l": "metal-dependent deNEDDylase activity", "d": ["An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32828", "l": "ATP + H2O + methionine(out) => ADP + H(+) + methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18439", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) => 4-CDP-2-C-methyl-D-erythritol + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57739", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol <=> AH2 + all-trans-3,4-didehydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419861", "l": "Melanospin is stimulated by light (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825275", "l": "Expression of DLL1 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25293", "l": "ethanol + NAD(+) <=> acetaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77045", "l": "5-hydroxyoctan-4-one + H(+) + NADH + NH4(+) => 5-hydroxyoctan-4-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052688", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."], "t": []}, {"i": "KEGG.REACTION:R06515", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29117", "l": "menaquinol-8 + NADP(+) => H(+) + menaquinone-8 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.-", "l": "\"Phosphotransferases with a carboxy group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40141", "l": "(9Z)-octadecenoate + CoA + H(+) => (9Z)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68631", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23843", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 <=> (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47422", "l": "(2E)-glutaconyl-CoA + AH2 => A + glutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26120", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658253", "l": "RAS:GTP binds PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13092", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) <=> 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26386", "l": "all-trans-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380311", "l": "Recruitment of Plk1 to centrosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73431", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18310", "l": "an N-acyl-D-amino acid + H2O => a carboxylate + a D-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68942", "l": "Na(+)(out) + tellurite(out) => Na(+)(in) + tellurite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21999", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66959", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45623", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30943", "l": "FAD + H(+) + octanoyl-CoA = (2E)-octenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49592", "l": "2-hydroxyisobutanoyl-CoA = (3S)-3-hydroxybutanoyl-CoA", "d": [], "t": []}, {"i": "EC:5.4.99.64", "l": "\"2-hydroxyisobutanoyl-CoA mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877158", "l": "P2X7 forms oligomeric non-selective cation channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47978", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.101", "l": "\"2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71879", "l": "2'-deoxyguanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49597", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10177", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51408", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23952", "l": "H2O + N-(2-phenylethyl)acetamide = 2-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29765", "l": "ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate => ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39573", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62112", "l": "(3S)-3-hydroxy-D-aspartate = H2O + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15274", "l": "2-oxoglutarate + L-dopa => 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990081", "l": "trimethylamine receptor activity", "d": ["Combining with the biogenic amine trimethylamine to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69296", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75708", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.3", "l": "\"D-amino-acid oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37924", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.12", "l": "\"carboxypeptidase M\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698844", "l": "MLKL binds HSP90:CDC37 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043544", "l": "lipoamide binding", "d": ["Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65058", "l": "7-oxoglycolithocholate + H(+) + NADPH => glycochenodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67888", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52593", "l": "deoxycholoyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173636", "l": "Formation of classic pathway C5 convertase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44647", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0030492", "l": "hemoglobin binding", "d": ["Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110311", "l": "POLZ extends translesion synthesis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.118", "l": "\"glucose 1-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21302", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate => H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76428", "l": "(2R,9S)-annullatin H + A => (2R)-annullatin F + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42070", "l": "clavulanate + NADP(+) => (3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615910", "l": "SUMOylation of PCNA with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11605", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA => [O(7),N-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65361", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39664", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55670", "l": "11-cis-retinal--[retinol-binding protein] + H(+) + NADH => 11-cis-retinol--[retinol-binding protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637766", "l": "Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14815", "l": "D-2-aminohexano-6-lactam => L-2-aminohexano-6-lactam", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51289", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047535", "l": "2-alkyn-1-ol dehydrogenase activity", "d": ["Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23332", "l": "(2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP", "d": [], "t": []}, {"i": "EC:2.7.2.10", "l": "\"phosphoglycerate kinase (GTP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0034458", "l": "3'-5' RNA helicase activity", "d": ["Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63007", "l": "(11Z,14Z)-eicosadienamide + H2O <=> (11Z,14Z)-eicosadienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.3", "l": "\"aldehyde dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44100", "l": "H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534365", "l": "Slo3 Potassium Transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66109", "l": "2-oxobutanoate + L-cysteine => (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62519", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GA2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33709", "l": "ADP + H(+) + O-phospho-L-threonine => ATP + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035976", "l": "Defective HEXA does not cleave the terminall GalNAc from small HA fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65397", "l": "8-oxo-dATP + H2O => 8-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46860", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24331", "l": "7,8-dihydrofolate + ATP + formate <=> 10-formyldihydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419334", "l": "Melatonin receptors can bind melatonin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39555", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047207", "l": "1,2-beta-fructan 1F-fructosyltransferase activity", "d": ["Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010283", "l": "pinoresinol reductase activity", "d": ["Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981657", "l": "IL34 dimer binds PTPRZ1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71177", "l": "2 chloride(in) + glycine betaine(in) + 3 Na(+)(in) => 2 chloride(out) + glycine betaine(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13142", "l": "2-methylpropanoyl-CoA => butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0043394", "l": "proteoglycan binding", "d": ["Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507875", "l": "Aquaporins passively transport urea into cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421831", "l": "trans-Golgi Network Coat Assembly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59762", "l": "apigenin 7-O-beta-D-glucoside + H(+) + UDP => apigenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20355", "l": "AH2 + tetrachloroethene => A + chloride + H(+) + trichloroethene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46573", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51274", "l": "CoA + H(+) + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72895", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine = 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69324", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33464", "l": "episterol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205231", "l": "Dimerization of KIT upon SCF binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685319", "l": "CX3 complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42418", "l": "(S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+) => a ubiquinone + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45245", "l": "(3E,5Z)-octadienoyl-CoA => (2E,4E)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110218", "l": "Cleavage of uracil by TDG glycosylase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917987", "l": "TFRC dimer binds 2xholoTF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202466", "l": "Interaction of Bcl10 to CARMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21223", "l": "L-dopa + O2 <=> 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74153", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin] => acetyl-CoA + L-lysyl-[beta-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250220", "l": "Homodimerization of ERBB4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299297", "l": "Activation of THIK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008327", "l": "methyl-CpG binding", "d": ["Binding to a methylated cytosine/guanine dinucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112437", "l": "Formation of NELF complex  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43536", "l": "2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.153", "l": "\"(5-formylfuran-3-yl)methyl phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601883", "l": "Complexed PIWIL4 binds cleaved transposon RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941895", "l": "Formation of CDK4/6:CCND complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37609", "l": "1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70985", "l": "glycine(in) + n H(+)(out) => glycine(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.16453130321915", "identifiers": [{"i": "GO:0001653", "l": "peptide receptor activity", "d": ["Combining with an extracellular or intracellular peptide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31070", "l": "6-amino-2-oxohexanoate <=> Delta(1)-piperideine-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11381", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678998", "l": "Endosomal TLRs pass through the Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66100", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = H2O + kynurenate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251942", "l": "Hikeshi binds HSP70s:ATP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798372", "l": "ATM phosphorylates DYRK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033924", "l": "dextran 1,6-alpha-isomaltotriosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58866", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13405", "l": "4-coumaroyl-CoA + agmatine = CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": [], "t": []}, {"i": "EC:2.3.1.64", "l": "\"agmatine N(4)-coumaroyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11785", "l": "H2O + L-aspartate + NADP(+) => H(+) + NADPH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0001227", "l": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042978", "l": "ornithine decarboxylase activator activity", "d": ["Binds to and increases ornithine decarboxylase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085992", "l": "SUMOylation of DAXX with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46343", "l": "ATP + N-hexadecanoylsphing-4-enine <=> ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928607", "l": "p-EPHs bind VAV2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36823", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": [], "t": []}, {"i": "EC:2.7.8.39", "l": "\"archaetidylinositol phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322422", "l": "Beta-catenin recruits SMARCA4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18766", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75037", "l": "1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263492", "l": "Defective HGSNAT does not acetylate Heparan chain(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662606", "l": "MT3 binds zinc (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848939", "l": "PTK6 binds KHDRBS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27682", "l": "ATP + dTDP = ADP + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168848", "l": "tBID binds to inactive BAK protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16829", "l": "an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21263", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190263", "l": "FGFR3b binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757459", "l": "ST metabolites diffuse out of ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672973", "l": "MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76590", "l": "(6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + 2-oxoglutarate + AH2 + H(+) + O2 <=> (2S)-5,5-dimethylpiperidine-2-carboxylate + A + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74684", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2219524", "l": "PDPK1 binds PIP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031752", "l": "D5 dopamine receptor binding", "d": ["Binding to a D5 dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810159", "l": "HOXB2 chromatin is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70119", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755526", "l": "PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047105", "l": "4-trimethylammoniobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12049", "l": "3-oxoadipate + succinyl-CoA => 3-oxoadipyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10653", "l": "a long-chain fatty aldehyde + H2O + NAD(+) => a long-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68767", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29049", "l": "a menaquinol + 2 H(+)(out) => a menaquinone + 2 H(+)(in) + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72103", "l": "Formation of pre-mRNPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660666", "l": "CBP and p300 binds NF-kB complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35386", "l": "precorrin-6B + S-adenosyl-L-methionine <=> CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50981", "l": "prostaglandin E1(out) => prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451819", "l": "YKI binds to HTH and TSH and activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46493", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47873", "l": "a ganglioside GM1 + H2O => a ganglioside GA1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66521", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37979", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine = 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15813", "l": "1H-imidazole + acetyl-CoA = CoA + N-acetylimidazole", "d": [], "t": []}, {"i": "EC:2.3.1.2", "l": "\"imidazole N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015426", "l": "ATPase-coupled polar amino acid-transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25873", "l": "H2O2 + pyridine => H2O + pyridine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875451", "l": "MET phosphorylates CBL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16732", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696268", "l": "RND3 binds effectors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168935", "l": "viral dsRNA binds DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045330", "l": "aspartyl esterase activity", "d": ["Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48730", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674563", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75951", "l": "2-oxoglutarate + O2 + oripavine = CO2 + formaldehyde + neomorphinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.279", "l": "\"trans-anol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080109", "l": "indole-3-acetonitrile nitrile hydratase activity", "d": ["Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190261", "l": "FGFR3c binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043730", "l": "5-ureido-4-imidazole carboxylate hydrolase activity", "d": ["Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67641", "l": "ATP + dZMP => ADP + dZDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018754", "l": "GDIs bind RHOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57699", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411383", "l": "NLK phosphorylates TCF/LEF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43701", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine => methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052831", "l": "inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.071377031489931", "identifiers": [{"i": "GO:0099528", "l": "G protein-coupled neurotransmitter receptor activity", "d": ["Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030797", "l": "24-methylenesterol C-methyltransferase activity", "d": ["Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65251", "l": "AH2 + 5 H(+) + 5 malonyl-CoA <=> 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23340", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate = D-arabinose + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.23", "l": "\"3-deoxy-D-manno-octulosonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61735", "l": "steviol + UDP-alpha-D-glucose <=> H(+) + steviolmonoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985227", "l": "The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033219", "l": "urea binding", "d": ["Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44967", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH <=> dodecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088441", "l": "FOXM1 stimulates CENPF transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.173", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19283", "l": "acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen => (7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42084", "l": "9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580292", "l": "Defective CYP11B1 does not oxidise 11DCORT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20493", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.244", "l": "\"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56034", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67628", "l": "ATP + dGMP + L-aspartate = (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.25", "l": "\"2-amino-2'-deoxyadenylo-succinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062206", "l": "manoyl oxide synthase activity", "d": ["Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41404", "l": "(R)-2-methylpyrrolidine + NADP(+) = 2-methyl-1-pyrroline + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.48", "l": "\"2-methyl-1-pyrroline reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652264", "l": "ERBB2 binds TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35713", "l": "acetyl-CoA + succinate => acetate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46285", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71552", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57470", "l": "1-O-[(E)-feruloyl]-beta-D-glucose + UDP => (E)-ferulate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850534", "l": "PDCL promotes G-protein beta 5 folding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876210", "l": "InlB promotes MET dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43920", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432164", "l": "Ca2+ influx into the post-synaptic cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070524", "l": "11-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683720", "l": "E protein gets palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49408", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate = [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.340", "l": "\"1,2-beta-oligomannan phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687465", "l": "MRN complex binds RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63637", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20247", "l": "3''-O-adenylylstreptomycin + diphosphate => ATP + streptomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53228", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35737", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2R)-2-hydroxycarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35992", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40112", "l": "butanoyl-CoA + H2O => butanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9703895", "l": "CASR binds CASR agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17012", "l": "2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11889", "l": "an aldehyde + H2O + NADP(+) => a carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002151", "l": "G-quadruplex RNA binding", "d": ["Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57689", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide => cob(II)inamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64829", "l": "3-hydroxybenzyl alcohol + acetyl-CoA => 3-hydroxy-benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023196", "l": "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14740", "l": "CTP <=> 3',5'-cyclic CMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14860", "l": "(indol-3-yl)acetate + ATP + L-lysine <=> ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806613", "l": "Keratin tetramers bind to form unit length filaments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32049", "l": "adenosine 5'-pentaphosphate + AMP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836270", "l": "TFAP2A binds TFAP2C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52022", "l": "A + H2O + resolvin E2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944265", "l": "Association of procollagen type IV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211959", "l": "CYP3A43 6b-hydroxylates TEST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68388", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848726", "l": "PTK6 phosphorylates BCAR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0050498", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated."], "t": []}, {"i": "EC:1.14.20.-", "l": "\"With 2-oxoglutarate as one donor, and the other dehydrogenated\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46307", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976768", "l": "Factor H binds to C3b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73512", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 => CO2 + formaldehyde + pilosin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40656", "l": "(R)-malate + succinyl-CoA => (R)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56651", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429036", "l": "SLC2A9 transports Fru, Glc, urate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21158", "l": "(R)-glycerate + phosphate => (2R)-2-phosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54805", "l": "2 4-sulfanylbutanoate + NAD(+) => 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62732", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500761", "l": "Nitrogen dioxide is reduced to NO by F420 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31604", "l": "(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11036", "l": "a quaternary ammonium(out) + ATP + H2O = a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.9", "l": "\"ABC-type quaternary amine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0038054", "l": "G protein-coupled estrogen receptor activity", "d": ["Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2430535", "l": "MASTL phosphorylates ENSA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624800", "l": "CDK1 phosphorylates LBR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043398", "l": "HLH domain binding", "d": ["Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28782", "l": "4-hydroxy-L-threonine <=> glycine + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49393", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9717841", "l": "holo-FDPS dimer binds NBPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75713", "l": "a rhodoquinol + fumarate => a rhodoquinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917700", "l": "MVB Vesicle Formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27321", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61152", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16822", "l": "6-phospho-D-gluconate + NAD(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27680", "l": "ADP + dCTP => ATP + dCDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662773", "l": "ADAM17 binds Zn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102436", "l": "7-methylmyricetin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine = 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10172", "l": "(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.22", "l": "\"hydroxybutyrate-dimer hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250264", "l": "TXNIP binds reduced thioredoxin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28449", "l": "1-deoxy-D-xylulose(in) <=> 1-deoxy-D-xylulose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.67", "l": "\"endopeptidase So\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749505", "l": "LRRC14 binds IKBKB and CHUK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49774", "l": "CoA + H(+) + N-hexacosanoylglycine => glycine + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57140", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71755", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) = 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35925", "l": "3''-deamino-3''-hydroxykanamycin B + H(+) + UDP => neamine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209944", "l": "25(OH)D binds GC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42053", "l": "9-cis-retinol + NAD(+) => 9-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65124", "l": "benzoyl-CoA + ethanol = benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53206", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64599", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15880", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate <=> D-glutamate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30221", "l": "dimethyl sulfone + H(+) + NADH => dimethyl sulfoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801776", "l": "REG3A binds bacterial phospholipids (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50525", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69283", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 3-hydroxypropyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64626", "l": "(2E)-geranyl acetate + CoA => (2E)-geraniol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912790", "l": "CBL binds CRK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641111", "l": "Parkin transfers Ub to misfolded proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686015", "l": "Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013009", "l": "RHOA binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72417", "l": "Li(+)(out) + Na(+)(in) => Li(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53487", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH <=> 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69116", "l": "Formation of Okazaki fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39914", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate <=> (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102570", "l": "tyrosine:phenylpyruvate aminotransferase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31463", "l": "crocetin + UDP-alpha-D-glucose = beta-D-glucosyl crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11923", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432010", "l": "Aquaporin-1 passively transports water into cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784204", "l": "JAKs bind OSMR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37196", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61531", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base <=> a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071532", "l": "ankyrin repeat binding", "d": ["Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964884", "l": "Dephosphorylation of EPSP yields chorismate (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4518585", "l": "NLK mRNA translation controlled by miR-92b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45485", "l": "H(+) + pyruvate => acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685011", "l": "ATR activation at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451311", "l": "Activation of Ca-permeable Kainate receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61122", "l": "2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase] => kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51732", "l": "glandicoline B + S-adenosyl-L-methionine = H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14866", "l": "S-adenosyl-L-methionine + tyramine => H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47030", "l": "[DsrC protein]-disulfide + H(+) + sulfite => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43636", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}, {"i": "EC:2.3.1.286", "l": "\"protein acetyllysine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67210", "l": "5-methoxytryptamine + acetate => H2O + melatonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042012", "l": "interleukin-16 receptor activity", "d": ["Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866277", "l": "AP-2 directly binds some endocytic cargo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047130", "l": "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770119", "l": "Formation of the Spliceosomal E complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39865", "l": "a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18227", "l": "6-aminohexanoate + [N-(6-aminohexanoyl)](n-1) => [N-(6-aminohexanoyl)](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71785", "l": "3-methyl-2-oxobutanoate(in) + H(+)(in) => 3-methyl-2-oxobutanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32152", "l": "9alpha-copalyl diphosphate => (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12536", "l": "H(+) + L-arogenate = CO2 + H2O + L-phenylalanine", "d": [], "t": []}, {"i": "EC:4.2.1.91", "l": "\"arogenate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17917", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine", "d": [], "t": []}, {"i": "EC:2.3.2.15", "l": "\"glutathione gamma-glutamylcysteinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379996", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51940", "l": "(1E,2S)-2-methylbutanal oxime = (1Z,2S)-2-methylbutanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39946", "l": "a 1-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47353", "l": "a hexanoate ester + H2O => an aliphatic alcohol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69675", "l": "eriodictyol-7-O-beta-D-glucoside + H2O = (S)-eriodictyol + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21715", "l": "L-threo-3-phenylserine <=> benzaldehyde + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.149", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53714", "l": "beta-hematin => 2 Fe(III)-heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68353", "l": "pppA(2'-5')pG => 3',2'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48164", "l": "epoxypheophorbide a + H2O = H(+) + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43046", "l": "CoA + H(+) + N-octadecanoylhexadecasphinganine => hexadecasphinganine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29123", "l": "nitrate(out) + ubiquinol-8(in) = H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31850", "l": "(S)-2,3-epoxysqualene <=> shionone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61983", "l": "H(+) + NADPH + ubiquinone-10 <=> NADP(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44928", "l": "2-oxoheptanedioate + acetyl-CoA + H2O = (R)-trihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848335", "l": "IL37 binds  IL18R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55978", "l": "H(+) + S-sulfanylglutathione + sulfite => glutathione + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40231", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141409", "l": "Mad1 binds kinetochore (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.40", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47628", "l": "glyoxylate + H2O + propanoyl-CoA = 3-methylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.126", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49930", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023451", "l": "FGFR1c P252X mutants bind ligand with enhanced affinity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60129", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218824", "l": "p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63969", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => atromentin + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75363", "l": "thymidine(in) = thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76252", "l": "glutarate(in) => glutarate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.31", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10947", "l": "H2O + psi-UMP <=> phosphate + pseudouridine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23219", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67182", "l": "ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + glycine + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45888", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63313", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77077", "l": "Capping complex formation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.11", "l": "\"glutamate carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.1", "l": "\"steroid Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996755", "l": "ZFPM proteins bind GATA proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592297", "l": "Full activation of MMP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33922", "l": "H(+) + lanosterol + NADPH <=> 24,25-dihydrolanosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48754", "l": "CO2 + H(+) + succinate + validamycin B => 2-oxoglutarate + O2 + validamycin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51388", "l": "acetyl-CoA + dopamine = CoA + H(+) + N-acetyl-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76687", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75133", "l": "morphinone => neomorphinone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.80", "l": "\"membrane-type matrix metalloproteinase-1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67634", "l": "a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin] => a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65725", "l": "2-oxoglutarate + O2 + pentyl sulfate => CO2 + H(+) + pentanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160141", "l": "23S rRNA pseudouridine(955/2504/2580) synthase activity", "d": ["Catalysis of the reaction: uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694522", "l": "Inner coat assembly and cargo binding (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120023", "l": "somatostatin binding", "d": ["Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141159", "l": "TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033720", "l": "(S)-mandelate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376122", "l": "DSCAM/DSCAML1 homodimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266303", "l": "Spherical HDL binds C and E apolipoproteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53113", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23764", "l": "diphosphate + L-serine = H(+) + O-phospho-L-serine + phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.80", "l": "\"diphosphate--serine phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55475", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38562", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate <=> (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59568", "l": "4-aminobutanoate + ATP + L-histidine = ADP + H(+) + L-homocarnosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015360", "l": "acetate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66871", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20265", "l": "2-oxoglutarate + L-proline + O2 = cis-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.28", "l": "\"proline 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694334", "l": "mRNA1 is translated to pp1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432054", "l": "Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68143", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH <=> (2R,5R)-hexanediol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29711", "l": "cadaverine(in) + H(+)(in) = cadaverine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004298", "l": "threonine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile."], "t": []}, {"i": "EC:3.4.25.-", "l": "\"Threonine endopeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41861", "l": "(3R)-hydroxydecanoyl-[ACP] => (2E)-decenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209178", "l": "N-HH binds to PTC receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17420", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13362", "l": "CTP + H(+) + sn-glycerol 3-phosphate => CDP-glycerol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15723", "l": "glyoxylate + H(+) + NADH + NH4(+) => glycine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76900", "l": "cyclohexylamine + H2O + NADP(+) => cyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18225", "l": "[N-(6-aminohexanoyl)](n) + H2O = 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42743", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114684", "l": "Phosphorylation of Syntaxin-4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16037", "l": "phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.820554254294692", "identifiers": [{"i": "GO:0016712", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19269", "l": "2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.31", "l": "\"2-furoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19249", "l": "glyoxylate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.9", "l": "\"NADH:ubiquinone reductase (non-electrogenic)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45173", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015189", "l": "L-lysine transmembrane transporter activity", "d": ["Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41083", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392870", "l": "Gs activation by prostacyclin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37354", "l": "cytidine 2'-phosphate + H2O <=> cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628737", "l": "NEIL1 G83D does not cleave DHU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46854", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21275", "l": "ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71295", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59477", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine => 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205136", "l": "GTP-bound RAC contributes to JNK activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50278", "l": "(12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052828", "l": "inositol-3,4-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.50", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32679", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geraniol + diphosphate", "d": [], "t": []}, {"i": "EC:3.1.7.11", "l": "\"geranyl diphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18127", "l": "a 2-oxocarboxylate + AH2 + NH4(+) => A + a D-alpha-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69803", "l": "ATP + benzoate + H(+) = benzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45759", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0070001", "l": "aspartic-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14640", "l": "3'-phosphoadenylyl sulfate + a thiol <=> adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082369", "l": "Acetylated HSF1 dissociates from DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47171", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50098", "l": "13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210300", "l": "Interaction of DAP12 and TREM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18038", "l": "agmatine + H2O => N-carbamoylputrescine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29605", "l": "4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18528", "l": "3-methylbutanol + NADP(+) <=> 3-methylbutanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24625", "l": "ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45246", "l": "(2E,4E)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66941", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine => 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14278", "l": "(S)-lactaldehyde + H2O + NAD(+) => (S)-lactate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985943", "l": "p-Y701-STAT1 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25503", "l": "(2E)-geranyl diphosphate <=> diphosphate + terpinolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948594", "l": "miR-19a microRNA binds VAPA mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66965", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23906", "l": "5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide] => an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18769", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": [], "t": []}, {"i": "EC:5.3.2.5", "l": "\"2,3-diketo-5-methylthiopentyl-1-phosphate enolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21579", "l": "carnitine + H(+) <=> 2-methylcholine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12871", "l": "(4S)-limonene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009485", "l": "IL34:CSF1 binds CSF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944257", "l": "Association of procollagen type XXIV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22189", "l": "an (R)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57886", "l": "H(+) + Na(+)(out) + 2 phosphate => diphosphate + H2O + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25374", "l": "(2S)-2-amino-4-deoxychorismate + FMN <=> 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47385", "l": "4-acetoxyphenol + H2O => acetate + H(+) + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55627", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O <=> 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64818", "l": "5-aminolevulinate(out) => 5-aminolevulinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52716", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650165", "l": "ASIC trimers bind H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33058", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> diphosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9010872", "l": "SLIT2 binds Dystroglycan (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58810", "l": "AMP + GMP + 2 H(+) => 2',3'-cGAMP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22297", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75096", "l": "2 chloride(in) + oxalate(out) => 2 chloride(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57454", "l": "H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine => L-glutaminyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618586", "l": "E2F1 binds the promoter of the MYC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944220", "l": "Association of procollagen type XXIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163310", "l": "TFAM binds to mitochondrial promoters (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983152", "l": "Transfer of ubiquitin from E1 to E2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65009", "l": "ATP + decanoate + H(+) => decanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011598", "l": "DOCKs bind to RhoGEFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.2", "l": "\"oxazoline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193695", "l": "IRAK interacts with TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655833", "l": "Expression of TM7SF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202714", "l": "CD58 binds CD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22778", "l": "2 H2O + 2 Mn(3+) => 2 H(+) + H2O2 + 2 Mn(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050186", "l": "phosphoadenylylsulfatase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.18", "l": "\"calcidiol 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76359", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098621", "l": "O-phosphoseryl-tRNA(Sec) selenium transferase activity", "d": ["Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031892", "l": "type 2 vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a type 2 vasoactive intestinal polypeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32346", "l": "(+)-thujan-3-ol + NAD(+) <=> (+)-thujan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64045", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749197", "l": "ORC1 binds to H4K20me2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50618", "l": "(3E)-nonen-2-one + H(+) + NADPH => NADP(+) + nonan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675473", "l": "SH2B binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676589", "l": "RANKL,sRANKL trimer binds RANK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60963", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844610", "l": "NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21281", "l": "H2O + 2 O2 + thiamine => H(+) + 2 H2O2 + thiamine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961982", "l": "RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629679", "l": "PDE3A inhibitors bind PDE3A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964886", "l": "EPSP from shikimate 3-phosphate (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050041", "l": "lactate aldolase activity", "d": ["Catalysis of the reaction: (S)-lactate = acetaldehyde + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033846", "l": "adenosyl-fluoride synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061770", "l": "translation elongation factor binding", "d": ["Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48233", "l": "acetyl-CoA + L-glutamate 5-semialdehyde => CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162229", "l": "The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67997", "l": "(Z)-1,2-dichloroethene + AH2 => A + chloride + chloroethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17044", "l": "adenosine 5'-phosphosulfate + H2O <=> AMP + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806732", "l": "GNLY binds the bacterial cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30323", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13467", "l": "CoA + N(3)-oxalyl-L-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12189", "l": "2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] => CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371590", "l": "HSP70 binds to HSP40:nascent protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35420", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004401", "l": "histidinol-phosphatase activity", "d": ["Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862184", "l": "USP48 cleaves polyubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53353", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) => H(+) + NADH + uridine(20b) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45725", "l": "(E)-4-coumaroyl alcohol + NADP(+) => (E)-4-coumaraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985943", "l": "p-Y701-STAT1 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28614", "l": "(1Z,2S)-2-methylbutanal oxime = (2S)-2-methylbutanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674018", "l": "BRAP binds RAS:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46110", "l": "(2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23400", "l": "7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.10", "l": "\"7,8-dihydroxykynurenate 8,8a-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52115", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047471", "l": "maltose alpha-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: maltose = trehalose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50474", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + CoA => anthraniloyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730892", "l": "Recruitment of VAV to p-SLP-76 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64756", "l": "H2O + S-benzyl-L-cysteine = benzylthiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15042", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O => inulobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391939", "l": "TP receptor can bind thromboxane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008970", "l": "phospholipase A1 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52357", "l": "3'-phosphoadenylyl sulfate + pregnenolone => adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008859", "l": "exoribonuclease II activity", "d": ["Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358545", "l": "EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67117", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433395", "l": "Dimerization of sSCF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24400", "l": "ATP + UMP = ADP + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64410", "l": "2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) => 2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949343", "l": "ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22864", "l": "L-lysine = D-lysine", "d": [], "t": []}, {"i": "EC:5.1.1.5", "l": "\"lysine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37980", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine => 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32503", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005096", "l": "GTPase activator activity", "d": ["Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950782", "l": "p-STAT1 binds p-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0036355", "l": "2-iminoacetate synthase activity", "d": ["Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26011", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31517", "l": "2 H(+) + NADH + neurosporaxanthin => 4'-apo-beta-carotenal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38276", "l": "(3R)-citramalyl-CoA => acetyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944684", "l": "miR-205 microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60635", "l": "all-trans-4-oxoretinol + NAD(+) <=> all-trans-4-oxoretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990698", "l": "palmitoleoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682826", "l": "LGI1 binds ADAM11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42383", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O <=> 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71519", "l": "uridine(out) = uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13698", "l": "ATP + D-ribose => ADP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757574", "l": "ALB binds PREDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.48", "l": "\"RNA-directed RNA polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102127", "l": "8-oxoguanine deaminase activity", "d": ["Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O = 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44556", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate = 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.731030655927583", "identifiers": [{"i": "GO:0005198", "l": "structural molecule activity", "d": ["The action of a molecule that contributes to the structural integrity of a complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11458", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018720", "l": "phenol kinase activity", "d": ["Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60662", "l": "hydroquinone + NAD(+) => 1,4-benzoquinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35976", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 => A + CO2 + H2O + succinate + verruculogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004994", "l": "somatostatin receptor activity", "d": ["Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65216", "l": "3-oxododecanoyl-CoA + H2O = 3-oxododecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848392", "l": "IL18BP binds IL18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507868", "l": "Aquaporins passively transport water into cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050331", "l": "thiamine-diphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420117", "l": "VEGFR2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24251", "l": "glyoxylate + L-alanine <=> glycine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428273", "l": "SPHK1 phosphorylates sphingoid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42515", "l": "5-acetamidopentanoate + H2O <=> 5-aminopentanoate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033887", "l": "chondro-4-sulfatase activity", "d": ["Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247843", "l": "secretion of WNT ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199839", "l": "AKT can phosphorylate RSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41422", "l": "CO2 + grixazone B + 4 H2O => 2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15601", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate = (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149519", "l": "MMACHC decyanates CNCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11259", "l": "H2O + limonin + UDP-alpha-D-glucose <=> glucosyl-limonin + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4411383", "l": "NLK phosphorylates TCF/LEF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45693", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) => N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799097", "l": "ATM phosphorylates ZNF420 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16140", "l": "2'-deoxymugineate + NADP(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56724", "l": "AH2 + all-trans-beta-carotene + O2 = 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856808", "l": "Recruitment of AP-2 complex and clathrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36819", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10169", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68858", "l": "(E)-beta-farnesene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23791", "l": "acetate + ATP + holo-[citrate lyase ACP] <=> acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698677", "l": "HCMV UL36 binds MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36816", "l": "dTDP-alpha-D-fucose => dTDP-alpha-D-fucofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72709", "l": "GDP-beta-L-fucose(out) + GMP(in) => GDP-beta-L-fucose(in) + GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13972", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209536", "l": "IkB is ubiquitinated and degraded (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203977", "l": "SAR1 Activation And Membrane Binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63003", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O <=> (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58027", "l": "oleanolate + UDP-alpha-D-glucose <=> H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29767", "l": "ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45511", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349520", "l": "Re-acidification of acetylcholine transport vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13399", "l": "2 H(+) + hexanedioate + NADPH => 6-oxohexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71183", "l": "L-kynurenine(out) + L-tryptophan(in) = L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0043860", "l": "cyanophycin synthetase activity", "d": ["Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35368", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH => isoheptadecanoyl-coA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71916", "l": "2 Na(+)(out) + tauronorcholate(out) => 2 Na(+)(in) + tauronorcholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52760", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O = (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662986", "l": "MT2A binds copper (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450422", "l": "KSRP recruits RNA degradation activities (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47497", "l": "lithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38946", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19516", "l": "carbamoyl phosphate + L-ornithine <=> H(+) + L-citrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "43.450838688746146", "identifiers": [{"i": "GO:0038023", "l": "signaling receptor activity", "d": ["Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2299620", "l": "Collagen XI cross-links with collagen II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943279", "l": "GGT dimers hydrolyse GSH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047936", "l": "glucose 1-dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5227009", "l": "ABCF1 binds EIF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47888", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25411", "l": "ADP-alpha-D-glucose + D-glucose <=> ADP + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57542", "l": "a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+) => a 5'-end NTP-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40378", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168445", "l": "PTP1B binds the GH receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24583", "l": "D-sorbitol 6-phosphate + H2O <=> D-sorbitol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12307", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786421", "l": "CHIA hydrolyses chitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051424", "l": "corticotropin-releasing hormone binding", "d": ["Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388808", "l": "CD28 homodimer binds B7-2 monomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42234", "l": "1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29248", "l": "3 H(+)(out) + 2 Na(+)(in) => 3 H(+)(in) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15470", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76037", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine => (S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59637", "l": "D-xylotriose + O2 => D-xylotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43263", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0034326", "l": "butanoyltransferase activity", "d": ["Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33963", "l": "ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate", "d": [], "t": []}, {"i": "EC:2.7.4.26", "l": "\"isopentenyl phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41649", "l": "aniline + ATP + L-glutamate => ADP + N(5)-phenyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55068", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54700", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23890", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71734", "l": "citrate(out) + tartrate(in) <=> citrate(in) + tartrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63999", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070457", "l": "D-galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214418", "l": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015264", "l": "methylammonium channel activity", "d": ["Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52460", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005340", "l": "nucleotide-sulfate transmembrane transporter activity", "d": ["Enables the transfer of nucleotide-sulfate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.124", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17640", "l": "squalene <=> hop-22(29)-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209218", "l": "Phosphorylated DL/DIF dimer activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76867", "l": "(R)-1-phenylethylamine + H2O + NAD(+) = acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53952", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate = 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465940", "l": "atRAL is reduced to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.18", "l": "\"cytosol non-specific dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11793", "l": "H(+) + NADH + O2 + propene => 1,2-epoxypropane + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.14", "l": "\"procollagen N-endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420980", "l": "Activation of Ca permeable AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12010", "l": "[G-protein-coupled receptor]-phosphate + ADP + H(+) => [G-protein-coupled receptor] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14927", "l": "D-mannose 6-phosphate + H(+) + NADPH => D-mannitol 1-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75886", "l": "NAD(+) <=> ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32290", "l": "(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5220959", "l": "TDG excises 5-formylcytosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63132", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27903", "l": "caffeine + H2O + ubiquinone-0 => 1,3,7-trimethylurate + ubiquinol-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70183", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose = alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52664", "l": "a short-chain (3S)-3-hydroxyacyl-CoA = a short-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.150", "l": "\"short-chain-enoyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76608", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O => (12Z,15Z)-10-hydroxyoctadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35253", "l": "ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047707", "l": "biotin-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74245", "l": "H(+) + L-alanine + tRNA(Pro) => H2O + L-alanyl-tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63010", "l": "(6Z)-octadecenoate + NH4(+) => (6Z)-octadecenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1671687", "l": "PRLR activation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28543", "l": "fluoroacetyl-CoA + H2O => CoA + fluoroacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28465", "l": "pyridoxal(in) <=> pyridoxal(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63773", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655245", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69321", "l": "glucoerucin + H2O => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15438", "l": "a long-chain fatty aldehyde + CoA + NADP(+) => a long-chain fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49241", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849900", "l": "SALMs1-3 bind each other in cis interactions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549304", "l": "OCT3 mediates renal clearance of organic cations (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52532", "l": "adenosine + GTP = AMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70440", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74272", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP => a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22054", "l": "AH2 + H(+) + hydroxylamine => A + H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57460", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870466", "l": "RGGT:CHM binds RABs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.100", "l": "\"sedolisin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030020", "l": "extracellular matrix structural constituent conferring tensile strength", "d": ["A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615249", "l": "ARBs bind AGRT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9842115", "l": "PSAP(195-273) dimer binds PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17571", "l": "1,2-dehydroreticuline + H(+) + NADPH => (R)-reticuline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39748", "l": "cholesterol(in) => cholesterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41511", "l": "L-ornithine + NADPH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24800", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O <=> (S)-2-amino-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27776", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74630", "l": "NADPH + 2 O2 + prefumagillin <=> acetaldehyde + fumagillin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28649", "l": "3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate => acetophenone + 2 ATP + H2O + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40127", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41024", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1467466", "l": "ABCA4 mediates atRAL transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41542", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35389", "l": "2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine => precorrin-7 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45735", "l": "D-ribulose 5-phosphate + L-tyrosine <=> (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327746", "l": "FN1 aggregation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16423", "l": "a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13618", "l": "H2O + S-methyl-5'-thioadenosine => 5-(methylsulfanyl)-D-ribose + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69094", "l": "2 H(+) + NADH + pentanoate => H2O + NAD(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694605", "l": "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38785", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29732", "l": "beta-maltose(in) => beta-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062150", "l": "amorpha-4,11-diene 12-monooxygenase activity", "d": ["Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43455", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42874", "l": "H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine => N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32030", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450488", "l": "BRF1 Complex recruits RNA degradation activities (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69104", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine = H2O + kynurenate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928620", "l": "PAK1 autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52445", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74509", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625426", "l": "Retrograde IFT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57724", "l": "H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate", "d": [], "t": []}, {"i": "EC:7.2.4.2", "l": "\"oxaloacetate decarboxylase (Na(+) extruding)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20698", "l": "H2O2 + O2 => 2 H(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33473", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066782", "l": "Translocation of DPA to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840334", "l": "PSAP gets cleaved (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172666", "l": "RB1 binds condensin II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20734", "l": "[protein]-disulfide + [thioredoxin]-dithiol => [protein]-dithiol + [thioredoxin]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76254", "l": "glutarate(in) <=> glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69315", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793485", "l": "PRKN polyubiquitinates RIPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35834", "l": "2-oxoglutarate + kanamycin B + O2 <=> 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.30", "l": "\"D-arabinonolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694363", "l": "Dimerisation of nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693198", "l": "RHOD binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42797", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol => cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362522", "l": "ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050353", "l": "trimethyllysine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509827", "l": "ITPA hydrolyses ITP to IMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855173", "l": "5-PP-IP4 transports from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25847", "l": "(1S,5R)-carveol + NAD(+) <=> (R)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45501", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296244", "l": "SUCNR1 binds SUCCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76191", "l": "carnosine(out) + 2 H(+)(out) = carnosine(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59726", "l": "D-maltoheptaonate + H(+) => D-maltoheptaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.85", "l": "\"S2P endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74837", "l": "UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out) => UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50284", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20272", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate <=> 2 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22216", "l": "(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.22", "l": "\"caffeate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32591", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O = (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71661", "l": "a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+) => a D-glucoside + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047595", "l": "6-hydroxynicotinate reductase activity", "d": ["Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170964", "l": "FRS2 binds to active TrkA receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18178", "l": "a 2,3-saturated acyl-CoA + NAD(+) => a (2E)-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40464", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64696", "l": "benzyl alcohol + NAD(+) = benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20507", "l": "5-oxo-L-proline + an L-alpha-amino acid => an alpha-(gamma-L-glutamyl)-L-amino acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031707", "l": "endothelin A receptor binding", "d": ["Binding to an endothelin A receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036218", "l": "dTTP diphosphatase activity", "d": ["Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33868", "l": "(S)-2-ureidoglycine + glyoxylate => glycine + N-carbamoyl-2-oxoglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730843", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357445", "l": "PAK1-3 dimer disassociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73876", "l": "(R)-adrenaline(out) => (R)-adrenaline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57312", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine = cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.129", "l": "\"N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70370", "l": "3-oxosphinganine + octanoyl-CoA <=> CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72917", "l": "D-fructopyranose(in) + Na(+)(in) => D-fructopyranose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545196", "l": "FN1 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247844", "l": "WNT ligands traffic to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21936", "l": "carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.6", "l": "\"putrescine carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047951", "l": "glutathione thiolesterase activity", "d": ["Catalysis of the reaction: S-acylglutathione + H2O = a carboxylate + glutathione + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58719", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin <=> FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442592", "l": "WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380042", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57222", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.25", "l": "\"saccharopepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674095", "l": "PDGFRs bind type II TKI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562541", "l": "TLR4-induced ripoptosome assembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729741", "l": "SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215295", "l": "USP7 deubiquitinates MDM2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770072", "l": "NPAS4 binds SYT10 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140679", "l": "ABC-type sodium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) = ADP + phosphate + Na(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21892", "l": "D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70793", "l": "H(+)(out) + L-ornithine(in) => H(+)(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20947", "l": "S-adenosyl-L-methionine + theobromine <=> caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848774", "l": "PTK6 binds DOK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45133", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10385", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate => beta-cyclopiazonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25022", "l": "CTP + riboflavin => CDP + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61365", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O => ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51419", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350058", "l": "Formation of CSL NCOR corepressor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204485", "l": "Basigin binds CyPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25608", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O <=> 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673231", "l": "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805103", "l": "AURKA phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61105", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389381", "l": "Gads binds CD28 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52798", "l": "Ni(2+) + sirohydrochlorin => 2 H(+) + Ni-sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28870", "l": "H(+)(in) + lactose(in) <=> H(+)(out) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51074", "l": "a phenol + an aryl sulfate => a phenol + an aryl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382056", "l": "Crk binds to the active PDGF receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29657", "l": "L-cysteine(out) => L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54170", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45702", "l": "formaldehyde + H2O + N,N-dimethylglycine + NAD(+) => glycine betaine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55808", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761852", "l": "NFE2L2-dependent TKT gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.19", "l": "\"procollagen C-endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047277", "l": "globoside alpha-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112436", "l": "Formation of Elongin complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198508", "l": "MDH1 oxidizes MAL to OA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028583", "l": "Phosphorylation of YAP by LATS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17724", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28011", "l": "propanoyl-CoA + succinate => propanoate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60125", "l": "pre-sodorifen diphosphate => diphosphate + sodorifen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10352", "l": "an N-acetylarylalkylamine + H2O = acetate + an aralkylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250220", "l": "Homodimerization of ERBB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29196", "l": "(S)-dihydroorotate + a menaquinone => a menaquinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71001", "l": "(S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47276", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.22", "l": "\"succinyl-CoA--L-malate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624949", "l": "Assembly of the anterograde IFT train (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48502", "l": "glycerol + H(+) + octanoate => H2O + octanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2317314", "l": "AKT binds PDPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351207", "l": "Spermine  => N-acetylated spermine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15335", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADPH => (S)-ureidoglycolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032405", "l": "MutLalpha complex binding", "d": ["Binding to a MutLalpha mismatch repair complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204871", "l": "Interaction of Tie2 and Grb2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710263", "l": "GZMB cleaves GSDME (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37635", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.169", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62871", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 <=> H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38268", "l": "2-methylfumaryl-CoA => 3-methylfumaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050218", "l": "propionate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783880", "l": "PIPOX oxidises PPCA to P6C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321975", "l": "NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033436", "l": "AUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.104", "l": "\"steryl-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69147", "l": "agmatine + H2O + O2 <=> 4-guanidinobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12501", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.-", "l": "\"With a iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61444", "l": "a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20988", "l": "ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693198", "l": "RHOD binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59089", "l": "D-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19937", "l": "glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": [], "t": []}, {"i": "EC:2.1.1.20", "l": "\"glycine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18248", "l": "3'-dephospho-CoA + ATP <=> ADP + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69638", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858428", "l": "FCAMR binds IgA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102842", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming)", "d": ["Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018573", "l": "NOTCH3 binds activated EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36624", "l": "3-phenylpyruvate + S-adenosyl-L-methionine => (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13861", "l": "D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41804", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59436", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] = 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374909", "l": "Catabolism of Noradrenaline (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33255", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine = H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050093", "l": "methanol dehydrogenase activity", "d": ["Catalysis of the reaction: methanol + NAD+ = formaldehyde + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018768", "l": "RHOU auto-activates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051912", "l": "CoB--CoM heterodisulfide reductase activity", "d": ["Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43591", "l": "a globoside NORint + UDP-alpha-D-galactose <=> a globoside NOR2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24286", "l": "4-phospho-L-aspartate + H(+) + NADPH => L-aspartate 4-semialdehyde + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36702", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <=> 8-desmethylnovobiocic acid + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71234", "l": "2 Fe(3+)-[Dph3] + NADH <=> 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350058", "l": "Formation of CSL NCOR corepressor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57413", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) => ATP + H(+) + L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47220", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12815", "l": "D-glutamate => L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161293", "l": "Tropoelastin forms aggregate globules (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39518", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466749", "l": "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69592", "l": "CMP + inosine = cytidine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190261", "l": "FGFR3c binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417842", "l": "P2Y10 receptor can bind to LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56511", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17384", "l": "(9Z,12Z)-octadecadienoate <=> (9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54866", "l": "4-methylpent-3-en-1-yl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + sulcatone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72046", "l": "L-glutamate(in) + orotate(out) <=> L-glutamate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481007", "l": "Exocytosis of platelet alpha granule contents (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008386", "l": "cholesterol monooxygenase (side-chain-cleaving) activity", "d": ["Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32272", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => 4-methyl-2-oxopentanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418172", "l": "F2R binds ARRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112703", "l": "PTPN11 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32486", "l": "H(+) + H2O + pheophorbide a <=> CO2 + methanol + pyropheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.63", "l": "\"caspase-10\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65648", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine = a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13005", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine = H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.115", "l": "\"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050335", "l": "thiocyanate isomerase activity", "d": ["Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65553", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37838", "l": "aklavinone + H(+) + NADPH + O2 <=> epsilon-rhodomycinone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27663", "l": "(S)-2-hydroxyglutarate + O2 => 2-oxoglutarate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641134", "l": "SMURF2 binds AXIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51304", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68409", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) => 2-oxosuberate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64105", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] => 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65422", "l": "GMP(out) + NAD(+)(in) => GMP(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20106", "l": "ADP + beta-D-fructose 6-phosphate => AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44153", "l": "1D-myo-inositol 2-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41780", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.5", "l": "\"flavone synthase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033863", "l": "ribose 1,5-bisphosphate phosphokinase activity", "d": ["Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53374", "l": "H(+) + NADH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35077", "l": "doxorubicin(out) + H(+)(in) => doxorubicin(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9671145", "l": "DKC1 binds SHQ1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851933", "l": "MET phosphorylates GAB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938853", "l": "CDK6 binds RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874184", "l": "CREB3L1 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167419", "l": "The receptor:G-protein complex releases GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46657", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => 5beta-androstane-3,17-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.3", "l": "\"gastricsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630045", "l": "Defective NTHL1 truncation mutants do not bind dihydrouracil (DHU) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57829", "l": "dIMP + H2O => 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202717", "l": "Heterodimerization of CEACAMs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625548", "l": "Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.726079367374183", "identifiers": [{"i": "GO:0015662", "l": "P-type ion transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48266", "l": "H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41396", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68034", "l": "(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+) => (S)-cystathionine ketimine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49209", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59346", "l": "D-maltobiono-1,5-lactone + H2O2 => D-maltose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30010", "l": "ATP + H2O + L-arabinose(out) <=> ADP + H(+) + L-arabinose(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661217", "l": "MT1A binds zinc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237119", "l": "Acireductone is oxidized to MOB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432148", "l": "Fgr may phosphorylate p38 MAPK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43988", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106325", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.67", "l": "\"cis-muuroladiene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23295", "l": "ATP + L-lombricine <=> ADP + H(+) + N-phospho-L-lombricine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46352", "l": "(2E)-decenoyl-CoA + H2O = 3-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57529", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68914", "l": "DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19930", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10250", "l": "diphosphate + dUMP + H(+) => dUTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65051", "l": "4-acetoxybenzyl alcohol + NAD(+) <=> 4-acetoxybenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45861", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62937", "l": "H2O + N(4)-acetyl-2'-deoxycytidine => 2'-deoxycytidine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77428", "l": "benzaldehyde + hydrogen cyanide => (S)-mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65229", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113402", "l": "Formation of DSIF:NELF:early elongation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26254", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 => 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64268", "l": "emodin anthrone + O2 = emodin + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56707", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004084", "l": "branched-chain-amino-acid transaminase activity", "d": ["Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25552", "l": "9alpha-copalyl diphosphate = diphosphate + stemar-13-ene", "d": [], "t": []}, {"i": "EC:4.2.3.33", "l": "\"stemar-13-ene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66706", "l": "CoA + H(+) + mycophenolate => H2O + mycophenolyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76387", "l": "ATP + L-glutamate + N(6)-hydroxy-L-lysine = 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46753", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71281", "l": "chloride(in) + L-leucine(in) + 2 Na(+)(in) => chloride(out) + L-leucine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755244", "l": "SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848250", "l": "ACBD6 binds LCFA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43928", "l": "pregn-5-ene-3,20-dione = progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140833", "l": "RNA polymerase II CTD heptapeptide repeat Y1 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphotyrosine (position 1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.154", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662606", "l": "MT3 binds zinc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71331", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) = chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30348", "l": "ATP + IDP => ADP + ITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44274", "l": "4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67726", "l": "CMP(in) + CMP-N-acetyl-beta-neuraminate(out) => CMP(out) + CMP-N-acetyl-beta-neuraminate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341048", "l": "SUMOylation of RXRA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23306", "l": "H(+) + tropate + tropine => atropine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648268", "l": "HTR1A binds HTR1A antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578777", "l": "DMPK phosphorylates PLN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16939", "l": "1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48449", "l": "a ganglioside GA2 + H2O => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71494", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49828", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008889", "l": "glycerophosphodiester phosphodiesterase activity", "d": ["Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481007", "l": "Exocytosis of platelet alpha granule contents (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58641", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77743", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0033721", "l": "aldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008915", "l": "lipid-A-disaccharide synthase activity", "d": ["Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53417", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine => 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428750", "l": "Gq activation by TP receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63528", "l": "[thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20933", "l": "L-erythrulose 1-phosphate => dihydroxyacetone phosphate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62085", "l": "ADP + D-glucosamine => AMP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45977", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45210", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1977959", "l": "ERBB4 forms heterodimers with EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74672", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) => UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36898", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985343", "l": "RUNX2 binds SOX9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67943", "l": "2-hydroxyoctanoate + O2 <=> 2-oxooctanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40180", "l": "decanoyl-CoA + O2 => (2E)-decenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18515", "l": "D-mannose + H2O2 => D-mannitol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56482", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031418", "l": "L-ascorbic acid binding", "d": ["Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18014", "l": "H2O + N(5)-ethyl-L-glutamine => ethylamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14861", "l": "(S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate", "d": [], "t": []}, {"i": "EC:1.3.1.15", "l": "\"dihydroorotate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18913", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602466", "l": "Activation of MT-MMPs by FURIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16665", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": [], "t": []}, {"i": "EC:3.3.2.7", "l": "\"hepoxilin-epoxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938938", "l": "RUNX1 and ELF1 bind the IL3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60358", "l": "anthranilate + H(+) + octanoate => H2O + N-octanoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73342", "l": "ATP + beta-alanine + H(+) <=> beta-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15898", "l": "4-acetamidobutanoate + H2O => 4-aminobutanoate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168376", "l": "STIM1 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863718", "l": "AGFG1 binds VAMP7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928617", "l": "EPHB2 binds KALRN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42823", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NADP(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50699", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62468", "l": "3,4-dihydroxybenzoate + ATP + H(+) = 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43329", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49462", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12715", "l": "a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+) => a nucleoside 5'-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68915", "l": "ATP + H(+) + NADPH + propanoate <=> AMP + diphosphate + NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186819", "l": "SH2 domain of Src binds to the active receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22566", "l": "a (2E)-enoyl-[ACP] + H(+) + NADPH => a 2,3-saturated acyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416929", "l": "PTGFR binds PGF2a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694522", "l": "Inner coat assembly and cargo binding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24024", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.115", "l": "\"5-hydroxydodecatetraenal 1-aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65372", "l": "a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate = a globoside MSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770142", "l": "Formation of the Spliceosomal B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75195", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) = 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22135", "l": "ATP + D-maltose(out) + H2O <=> ADP + D-maltose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45756", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804099", "l": "HMGB1 binds LTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21973", "l": "precorrin-1 + S-adenosyl-L-methionine => precorrin-2 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.197", "l": "\"high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57431", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] <=> formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51746", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23945", "l": "(E)-coniferol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15790", "l": "L-xylose + NADP(+) => H(+) + L-xylono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31721", "l": "11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018590", "l": "methylsilanetriol hydroxylase activity", "d": ["Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64739", "l": "4-hydroxynonanal + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314686", "l": "ASA- acetylates PTGS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070205", "l": "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity", "d": ["Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009882", "l": "blue light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23177", "l": "acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21094", "l": "dihydromacarpine + H(+) + S-adenosyl-L-homocysteine => 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097247", "l": "epigallocatechin 3-gallate binding", "d": ["Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44755", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051743", "l": "red chlorophyll catabolite reductase activity", "d": ["Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0050253", "l": "retinyl-palmitate esterase activity", "d": ["Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004530", "l": "deoxyribonuclease I activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47879", "l": "a ganglioside GD1b + H2O <=> a ganglioside GM1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.224", "l": "\"violacein synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858475", "l": "TNFSF9 binds TNFRSF9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381109", "l": "IRE1 binds IRE1 forming dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29560", "l": "H2O + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36931", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38358", "l": "(R)-3-phenyllactoyl-CoA <=> (E)-cinnamoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47372", "l": "a quinone + D-glucose = a quinol + D-glucono-1,5-lactone", "d": [], "t": []}, {"i": "EC:1.1.5.9", "l": "\"glucose 1-dehydrogenase (FAD, quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481009", "l": "Exocytosis of platelet dense granule content (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35860", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13249", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.268", "l": "\"2-(R)-hydroxypropyl-CoM dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021946", "l": "MECP2 binds GPRIN1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66826", "l": "2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429497", "l": "SLP-76 stimulates PLC gamma 2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13980", "l": "D-serine <=> NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32051", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654510", "l": "FGFRL1 binds SPRED1/2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.43", "l": "\"beta-L-rhamnosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421517", "l": "Transport of delta-aminolevulinate from the mitochondrial matrix to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40660", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59052", "l": "D-lysine + H(+) = cadaverine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396009", "l": "STING binds c-di-GMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351208", "l": "Spermidine  => N-acetylated spermidine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18299", "l": "a primary amine + phthalate => a phtalamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928657", "l": "MMP2,9 cleave EPHB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26456", "l": "acryloyl-CoA + H(+) + NADPH => NADP(+) + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167019", "l": "SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052816", "l": "long-chain fatty acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}, {"i": "RHEA:67680", "l": "a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69935", "l": "guanosine(out) + Na(+)(out) = guanosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877153", "l": "STARD7 binds PC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73795", "l": "dimethylallyl diphosphate + neoechinulin A = diphosphate + isoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20935", "l": "L-erythrulose 1-phosphate <=> dihydroxyacetone phosphate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76115", "l": "2-oxoglutarate + O2 + thebaine = 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050026", "l": "L-glycol dehydrogenase activity", "d": ["Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64508", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975594", "l": "PLB1 hydrolyses RPALM to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56740", "l": "a globoside Gb3Cer + UDP-alpha-D-galactose = a globoside GalGb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77132", "l": "1D-myo-inositol 1,2,6-trisphosphate + H2O => 1D-myo-inositol 1,2-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58824", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.37", "l": "\"luteothin monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893597", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48648", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49261", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] => D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56711", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63921", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134914", "l": "Beta-catenin migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66628", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 = (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950456", "l": "IL12B dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43707", "l": "ATP + H(+) + tetradecanoate <=> diphosphate + tetradecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731141", "l": "Syndecan-1 binds fibronectin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830373", "l": "Expression of PCDH19 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800298", "l": "HGF dimer binds MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43482", "l": "1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37111", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10805", "l": "(S)-allantoin => (R)-allantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956684", "l": "ITCH polyubiquitinates TP73 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68562", "l": "1-arsono-3-phospho-D-glycerate + H(+) + NADH => arsenate + D-glyceraldehyde 3-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40764", "l": "(20S)-ginsenoside Re + H2O => (20S)-ginsenoside Rg1 + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109813", "l": "GRB2-1 binds SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41209", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953398", "l": "PIR oxygenates quercetin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.26", "l": "\"sterol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080012", "l": "trihydroxyferuloyl spermidine O-methyltransferase activity", "d": ["Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212432", "l": "Formation of DRIP coactivator complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15619", "l": "Fe(2+) + Fe(III)-[cytochrome c] => Fe(3+) + Fe(II)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-434650", "l": "MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32344", "l": "(+)-thujan-3-ol + NAD(+) => (+)-thujan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41759", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418858", "l": "RhoGTPase GEF's recruited to DCC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77710", "l": "GTP + UTP <=> 3',3'-cGMP-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35184", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O => 4-carboxy-2-thioxobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43691", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate <=> L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374337", "l": "Apelin receptor binds to apelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44782", "l": "H(+) + menaquinol-9 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-9 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76455", "l": "(E)-coniferol + A = (E)-coniferaldehyde + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008883", "l": "glutamyl-tRNA reductase activity", "d": ["Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74246", "l": "H2O + L-alanyl-tRNA(Pro) <=> H(+) + L-alanine + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50535", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57524", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52769", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O => 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222644", "l": "TrxA/B1 reactivates Tpx (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166726", "l": "Activation of MASPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44516", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875531", "l": "MET binds TNS4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470009", "l": "Phosphorylation of STATs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986939", "l": "MECP2 binds the NCoR/SMRT complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49162", "l": "2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50490", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169847", "l": "Assembly of NA tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63035", "l": "a fatty acylamide + H2O <=> a fatty acid + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033201", "l": "alpha-1,4-glucan synthase activity", "d": ["Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31315", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18847", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADH => (R)-glycerate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853429", "l": "PHLDA1 binds AURKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029471", "l": "Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607740", "l": "PKC-delta phosphorylates CARD9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371591", "l": "Trimerization of cytosolic HSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15366", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.3", "l": "\"uridine phosphorylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38168", "l": "hexadecan-1-ol + hexadecanoyl-CoA => CoA + hexadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64382", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2 => 3 A + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617479", "l": "HOXA2 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47439", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617683", "l": "EP300,CREBBP bind SOH-C481-FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61904", "l": "betaenone A + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983153", "l": "E1 mediated ubiquitin activation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20567", "l": "(1S,2S,4R)-endo-fenchol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40979", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56610", "l": "L-serine + tetrahydrosulfopterin => 5,10-methylenetetrahydrosulfopterin + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182986", "l": "CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63013", "l": "(2E,6E)-farnesyl diphosphate + orsellinate => diphosphate + ilicicolinate B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60182", "l": "ADP + D-fructose(in) + H(+) + phosphate => ATP + D-fructose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032408", "l": "MutSbeta complex binding", "d": ["Binding to a MutSbeta mismatch repair complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50801", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(S)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30535", "l": "biotinate sulfoxide + H(+) + NADPH = biotin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13384", "l": "acetate + an acyl-CoA <=> a carboxylate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13429", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.60", "l": "\"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46788", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71700", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) => H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62274", "l": "8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine => 4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.21", "l": "\"membrane-oligosaccharide glycerophosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32697", "l": "(-)-car-3-ene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683774", "l": "p-T68-CHEK2 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10551", "l": "L-arginine + O2 <=> 4-guanidinobutanamide + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69193", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71973", "l": "3-hydroxyglutarate(in) + 3 Na(+)(in) => 3-hydroxyglutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40007", "l": "(+)-copalyl diphosphate + H2O = (+)-copalol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41052", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51584", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.13", "l": "\"crotonobetainyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37336", "l": "5,6-dihydrothymine + H2O => 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12347", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) <=> H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446187", "l": "ALG11 transfers the fourth and fifth Man to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683718", "l": "Protein M localizes to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47984", "l": "H2O + presqualene diphosphate = diphosphate + hydroxysqualene", "d": [], "t": []}, {"i": "EC:4.2.3.156", "l": "\"hydroxysqualene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010945", "l": "coenzyme A diphosphatase activity", "d": ["Catalysis of the reaction:an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine. This reaction can also use coenzyme A as a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15410", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604969", "l": "Active FLT3 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73115", "l": "quercetin + S-adenosyl-L-methionine = H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63480", "l": "NADP(+) + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46295", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35365", "l": "isopentadecanoyl-CoA + NADP(+) => (2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120152", "l": "calcium-dependent outer dynein arm binding", "d": ["Binding to an outer dynein arm in the presence of calcium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64963", "l": "dTDP + H2O <=> dTMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12228", "l": "ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": [], "t": []}, {"i": "EC:6.3.5.4", "l": "\"asparagine synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58118", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66097", "l": "3-phenylpyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56642", "l": "(9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180602", "l": "Association of Vif with APOBEC3G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42249", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34182", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide <=> D-glucuronate + H(+) + mycophenolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814555", "l": "Integrator complex processes the 3' end of snRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613460", "l": "ID1 and ID3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52006", "l": "2 H(+) + NADH + pyruvate => H2O + methylglyoxal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63955", "l": "a sphingoid 1-phosphate + H2O <=> a sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42569", "l": "2,3-dihydroxy-p-cumate + O2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31898", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-humulene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45124", "l": "acarbose + ATP = acarbose 7(IV)-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.187", "l": "\"acarbose 7(IV)-phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051264", "l": "mono-olein transacylation activity", "d": ["Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74917", "l": "a (2E)-2-fatty-enoyl-AMP + diphosphate => a (2E)-enoyl fatty acid + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32193", "l": "2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37343", "l": "adenosine 2'-phosphate + H2O = adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76823", "l": "H2O + methylamine + NAD(+) = formaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13822", "l": "2-oxoglutarate + glutarate + O2 => (S)-2-hydroxyglutarate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43872", "l": "3-oxochol-4-en-22-oate + ATP + CoA = 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76258", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA <=> (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198611", "l": "AKT phosphorylates IKKalpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70596", "l": "GOT2 dimer deaminates L-Asp (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12959", "l": "acetate + an aliphatic alcohol + H(+) => an acetyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43204", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.227", "l": "\"16S rRNA (cytidine(1409)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635854", "l": "GLI2,3 are degraded by the proteasome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836702", "l": "PKR inhibitors bind PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23052", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": [], "t": []}, {"i": "EC:2.7.11.2", "l": "\"[pyruvate dehydrogenase (acetyl-transferring)] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16937", "l": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.93", "l": "\"alkylglycerol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018719", "l": "6-aminohexanoate transaminase activity", "d": ["Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27999", "l": "H2O + thiamine diphosphate => H(+) + phosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15141", "l": "4-methylphenol + H2O + 4 oxidized [azurin] = 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": [], "t": []}, {"i": "EC:1.17.9.1", "l": "\"4-methylphenol dehydrogenase (hydroxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043750", "l": "phosphatidylinositol alpha-mannosyltransferase activity", "d": ["Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467775", "l": "Autocleavage of ESPL1 (Separase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31965", "l": "9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008123", "l": "cholesterol 7-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209924", "l": "Dopa is decarboxylated to dopamine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44870", "l": "1,2-diacyl-sn-glycero-3-phosphoethanol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54303", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate <=> n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17732", "l": "an acyl-CoA + cholesterol <=> a cholesterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49012", "l": "aurachin C + H(+) + NADH + O2 = aurachin C epoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52192", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322125", "l": "Defective MMAB does not transfer adenosyl group from ATP to B12s (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31039", "l": "dodecanoyl-CoA + FAD + H(+) = (2E)-dodecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466802", "l": "Defective ABCA4 does not transport NRPE from disc membranes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50638", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 3-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102921", "l": "mannosylglycerate synthase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate = H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55753", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74191", "l": "carbofuran + H(+) + H2O = 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817942", "l": "Expression of LEUTX in the embryo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21616", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.4", "l": "\"beta-galactoside alpha-2,3-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57807", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 4-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9842656", "l": "ALK binds ALKAL ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848751", "l": "PTK6 binds AKT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.33144287441435", "identifiers": [{"i": "GO:0019205", "l": "nucleobase-containing compound kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61952", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264615", "l": "Loading of acetylcholine in synaptic vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918225", "l": "TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17151", "l": "an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an organic molecule + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017166", "l": "vinculin binding", "d": ["Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928627", "l": "EPHB phosphorylates TIAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928648", "l": "SFKs phosphorylate NGEF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33500", "l": "H(+) + prephenate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49919", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73293", "l": "H(+)(in) + L-valine(out) => H(+)(out) + L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26373", "l": "[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18804", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate <=> (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40047", "l": "1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30377", "l": "(+)-thujopsene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641206", "l": "RSPOs bind LGRs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088130", "l": "PLK1 binds FOXM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72366", "l": "chloride(out) + hydrogencarbonate(in) <=> chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0017069", "l": "snRNA binding", "d": ["Binding to a small nuclear RNA (snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110219", "l": "Cleavage of thymine by TDG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50087", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2248891", "l": "M6PR transports activated ARSA to the lysosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141094", "l": "DNA loop anchor binding", "d": ["Binding to a DNA loop anchor, a region of chromosome that defines the ends of a DNA loop where two parts of same DNA strand are held in close physical proximity. For example, in animals, the anchors of DNA loops are convergently oriented CTCF binding sites during interphase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0070739", "l": "protein-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28195", "l": "(2S)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76821", "l": "H(+) + NADH + NH4(+) + oxaloacetate => D-aspartate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374919", "l": "Noradrenaline clearance from the synaptic cleft (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22746", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27678", "l": "ATP + dCDP = ADP + dCTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000319", "l": "sulfite transmembrane transporter activity", "d": ["Enables the transfer of sulfite ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210837", "l": "HNF6-dependent synthesis of ONECUT3 protein during morphogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15866", "l": "AH2 + O2 + tryptamine => 4-hydroxytryptamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72461", "l": "fumarate(out) + L-aspartate(in) => fumarate(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0035325", "l": "Toll-like receptor binding", "d": ["Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106340", "l": "tRNA (guanine(34)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 34 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 34 in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61312", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001055", "l": "RNA polymerase II activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038658", "l": "RHD gene produces PALM-C-Rhesus D protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663245", "l": "NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443439", "l": "c-Src binds Raf1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198621", "l": "AKT phosphorylates caspase-9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694792", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29286", "l": "L-alanine(in) + Na(+)(in) <=> L-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76646", "l": "xanthine(out) <=> xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033550", "l": "MAP kinase tyrosine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710263", "l": "GZMB cleaves GSDME (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674529", "l": "AAMP binds to TBXA2R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937792", "l": "RUNX3 binds SRC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66476", "l": "gypsogenate + UDP-alpha-D-glucose = gypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65001", "l": "holo-[ACP] + octanoyl-AMP => AMP + H(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19636", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) <=> (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54277", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27641", "l": "phosphate + xanthosine <=> alpha-D-ribose 1-phosphate + xanthine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004908", "l": "interleukin-1 receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610038", "l": "Defective GALT does not transfer UMP to Gal1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46783", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40727", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14534", "l": "creatinine + H2O => creatine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74666", "l": "acetylcholine(in) <=> acetylcholine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58613", "l": "2 L-ascorbate + N-octanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60195", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621356", "l": "PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17426", "l": "CoA + NADP(+) + pyruvate => acetyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47651", "l": "D-ribitol 5-phosphate + H2O <=> phosphate + ribitol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23946", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP => (E)-coniferol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31127", "l": "3-O-methylgallate + O2 = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937369", "l": "ATAD2 binds ESR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68027", "l": "H2O + presqualene monophosphate <=> phosphate + presqualene alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391865", "l": "Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004333", "l": "fumarate hydratase activity", "d": ["Catalysis of the reaction: (S)-malate = fumarate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56221", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51841", "l": "2 Na(+)(out) + tauroallocholate(out) => 2 Na(+)(in) + tauroallocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51107", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043214", "l": "ABC-type bacteriocin transporter activity", "d": ["Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981657", "l": "IL34 dimer binds PTPRZ1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27865", "l": "3'-GMP + H2O <=> guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35819", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) = 7,8-dihydromethanopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16441", "l": "H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.44", "l": "\"protein-glutamine glutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41217", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.23", "l": "\"tyrosine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009558", "l": "IL34 dimer binds SDC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31917", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ATP + D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071614", "l": "linoleic acid epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47726", "l": "5-oxo-L-proline + L-cysteinylglycine => glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051722", "l": "protein C-terminal methylesterase activity", "d": ["Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol."], "t": []}, {"i": "REACT:R-HSA-8856951", "l": "PP2A demethylation by PPME1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936667", "l": "sulfate binds to SubI outside the membrane (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691167", "l": "CUL1, SKP1, FBXL5 bind (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008854", "l": "exodeoxyribonuclease V activity", "d": ["Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019119", "l": "phenanthrene-9,10-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866269", "l": "ARRB bind GPCRs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052727", "l": "capsanthin synthase activity", "d": ["Catalysis of the reaction: antheraxanthin = capsanthin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54238", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-didecanoyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805792", "l": "p-S291-PHF20 translocates to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34196", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 => 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417927", "l": "P2Y2 receptor binds ATP and UTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9736953", "l": "FURIN translocates to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050168", "l": "pentanamidase activity", "d": ["Catalysis of the reaction: H2O + pentanamide = NH4 + valerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0005184", "l": "neuropeptide hormone activity", "d": ["The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73625", "l": "CTP(in) + GDP(out) => CTP(out) + GDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0048030", "l": "disaccharide binding", "d": ["Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15721", "l": "glycine + H2O + NAD(+) = glyoxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.10", "l": "\"glycine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0019962", "l": "type I interferon binding", "d": ["Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106264", "l": "protein serine kinase activity (using GTP as donor)", "d": ["Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H+ + O-phospho-L-seryl-[protein]."], "t": []}, {"i": "RHEA:64020", "l": "GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37001", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49050", "l": "1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin] => 25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15761", "l": "L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70573", "l": "argininosuccinate <=> fumarate + arginine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73169", "l": "CoA(in) + NAD(+)(out) => CoA(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66367", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O <=> 6-methyl-3,7-dioxodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76045", "l": "2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193964", "l": "CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19774", "l": "NADP(+) + sn-glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65671", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030699", "l": "glycine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + H2O + NH4 + thioredoxin disulfide = glycine + H+ + phosphate + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006850", "l": "IL21 receptor JAK phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45306", "l": "1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444523", "l": "Formation of MSH1:PMS2 Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61898", "l": "betaenone A => betaenone C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050455", "l": "columbamine oxidase activity", "d": ["Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198714", "l": "ERK5 translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51730", "l": "dihydroxyacetone + phosphate => dihydroxyacetone phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38605", "l": "2'-phospho-cyclic ADP-ribose + nicotinamide => NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30049", "l": "chloroacetate + 2 H(+) + NADH => chloroacetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35559", "l": "H(+) + menaquinone-7 + NADH = menaquinol-7 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23323", "l": "D-tryptophan + malonyl-CoA <=> CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204600", "l": "Basigin homodimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74632", "l": "3-methyl-2-oxobutanoate + O-acetyl-L-homoserine => (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2214351", "l": "PLK1 phosphorylates GORASP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51349", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine => 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662608", "l": "MT2A binds cadmium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858482", "l": "DVL is recruited to the receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649856", "l": "Oxidative damage to the AP site (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374251", "l": "DARC  is a non-specific receptor for many chemokines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70456", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63431", "l": "ATP + H2O + levoglucosan <=> ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047599", "l": "8-oxocoformycin reductase activity", "d": ["Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + 2 H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.90", "l": "\"glyceraldehyde-3-phosphate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38318", "l": "chorismate <=> 3-hydroxybenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.96", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51220", "l": "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.88", "l": "\"L-glutamate gamma-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73508", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine => 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33040", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114553", "l": "Activation of conventional Protein Kinase C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674531", "l": "AAMP binds EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35620", "l": "L-idarate => D-glucarate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395992", "l": "p-T,4S-IRF3 is dimerized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689544", "l": "UCHL5 binds INO80 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43044", "l": "hexadecasphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30524", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 => GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004350", "l": "glutamate-5-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004535", "l": "poly(A)-specific ribonuclease activity", "d": ["Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53628", "l": "(2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.160", "l": "\"(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48312", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.208", "l": "\"benzoyl-CoA 2,3-epoxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44134", "l": "2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine => 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701507", "l": "PTPN6 dephosphorylates JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218814", "l": "PAK2 autophorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61701", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] => AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421831", "l": "trans-Golgi Network Coat Assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12443", "l": "H2O + L-saccharopine + NAD(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.53", "l": "\"3alpha(or 20beta)-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29097", "l": "4 H(+)(out) + NAD(+) + ubiquinol-8 => 5 H(+)(in) + NADH + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31605", "l": "(Z)-3-aminoacrylate + carbamate + H(+) => (Z)-3-ureidoacrylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008904", "l": "hygromycin-B 7''-O-phosphotransferase activity", "d": ["Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113429", "l": "Elongating transcript encounters a lesion in the template (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047614", "l": "aconitate delta-isomerase activity", "d": ["Catalysis of the reaction: trans-aconitate = cis-aconitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225956", "l": "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051720", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50615", "l": "decanal + NADP(+) <=> (2E)-decenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46216", "l": "H(+) + NADPH + progesterone = 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700120", "l": "PTN and MDK bind to PTPRZ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53379", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.213", "l": "\"galactan exo-1,6-beta-galactobiohydrolase (non-reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35505", "l": "30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570573", "l": "Defective RFT1 does not flip the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54639", "l": "(13E)-labda-7,13-dien-15-yl diphosphate <=> diphosphate + labda-7,13(16),14-triene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004782", "l": "sulfinoalanine decarboxylase activity", "d": ["Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21053", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111970", "l": "PKC phosphorylates GRK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645134", "l": "p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21854", "l": "(9Z)-octadecenoate + H2O => (R)-10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805059", "l": "CK2:FACT phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.13", "l": "\"succinate--hydroxymethylglutarate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050061", "l": "long-chain-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046904", "l": "calcium oxalate binding", "d": ["Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24678", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.147", "l": "\"5,6,7,8-tetrahydromethanopterin hydro-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005497", "l": "androgen binding", "d": ["Binding to an androgen, a male sex hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679775", "l": "COMT binds COMT Inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390912", "l": "HRH1 binds hist (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32023", "l": "(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.96", "l": "\"avermitilol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032018", "l": "2-methylbutanol:NADP oxidoreductase activity", "d": ["Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28667", "l": "H(+) + hydroxyacetone + NADH = (S)-propane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74656", "l": "ITP + N-acetyl-D-glucosamine => H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32749", "l": "ethanolamine(out) => ethanolamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167630", "l": "Formation of Nef CD28 cytoplasmic tail complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75340", "l": "chloride(out) + nitrate(in) => chloride(in) + nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13196", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2859050", "l": "Hydrolysis of C4b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27858", "l": "2',3'-cyclophospho-GMP + H2O = 3'-GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.162", "l": "\"lambda-carrageenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627775", "l": "Autophosphorylation of PAK1,2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21673", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41558", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033759", "l": "flavone synthase activity", "d": ["Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27794", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.30", "l": "\"heptaprenyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848250", "l": "ACBD6 binds LCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018766", "l": "RHOU binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55339", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine <=> a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43674", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052621", "l": "diguanylate cyclase activity", "d": ["Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65482", "l": "CoA + hexyl 2-methylbutanoate => 2-methylbutanoyl-CoA + hexan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981892", "l": "Active G alpha (z) binds RGS proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54154", "l": "a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50593", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) => 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74846", "l": "3'-phosphoadenylyl sulfate + a ganglioside GM1b <=> adenosine 3',5'-bisphosphate + an 8-O-sulfo-ganglioside GM1b + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.36", "l": "\"signal peptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202443", "l": "Oligomerization of CARMA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13670", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73128", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70087", "l": "methanol + o-quinone methide = hydroxyclavatol methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11266", "l": "H2O2 + NAD(+) => H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63323", "l": "a glycerophospholipid(in) + ATP + H2O <=> a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696564", "l": "USP25 deubiquitinates DDX58 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000834", "l": "inositol heptakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009670", "l": "triose-phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone => 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34105", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52438", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11307", "l": "(S)-ureidoglycolate <=> glyoxylate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982810", "l": "JAK2 phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55974", "l": "CoA + ethyl acetate => acetyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686710", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69155", "l": "spermine monoaldehyde <=> acrolein + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727188", "l": "ATP4A:ATP4B binds PPIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176452", "l": "Degradation of ubiquitinated SMAD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047393", "l": "glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity", "d": ["Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57922", "l": "H(+) + L-asparaginyl-tRNA(Asn) + phosphate => 4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18073", "l": "(S)-dihydroorotate + A = AH2 + orotate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016018", "l": "cyclosporin A binding", "d": ["Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047366", "l": "quercetin-3-sulfate 4'-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,4'-disulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24097", "l": "isoorientin + S-adenosyl-L-methionine => H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62463", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60230", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432428", "l": "Cytosolic CRY is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48434", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => ATP + N(6)-D-ribulosyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66648", "l": "(2E,6E)-farnesyl diphosphate = african-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59131", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40063", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17592", "l": "2,2'-iminodipropanoate + H2O + NAD(+) <=> H(+) + L-alanine + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14715", "l": "5-dehydro-D-fructose + AH2 => A + keto-L-sorbose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49235", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139842", "l": "Binding of Syk tyrosine kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76822", "l": "D-aspartate + H2O + NAD(+) <=> H(+) + NADH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36963", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050446", "l": "azobenzene reductase activity", "d": ["Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27694", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3777129", "l": "HDAC3 containing complexes deacetylate histone (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839073", "l": "HTRA2 binds NDUFA13 (GRIM-19) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064932", "l": "WWTR1 (TAZ) binds RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114552", "l": "Thrombin-activated PARs activate G12/13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684052", "l": "PIAS4 SUMOylates MDC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789524", "l": "Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350486", "l": "DSH binds to FZ at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75270", "l": "D-arabinose + NADP(+) <=> D-arabinono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30545", "l": "(S)-carnitinyl-CoA + ADP + phosphate => (S)-carnitine + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28988", "l": "H(+)(in) + N-acetylneuraminate(in) => H(+)(out) + N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34290", "l": "2 L-dopa + O2 <=> 2 H2O + 2 L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46641", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-990489", "l": "Kinesin-13 is a dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450550", "l": "PKCalpha phosphorylates HuR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216045", "l": "Collagen type I binds integrin alpha11beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112436", "l": "Formation of Elongin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28003", "l": "beta-D-fructose 6-phosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74967", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) = a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026890", "l": "NTRK2 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42969", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071160", "l": "cyanophycin synthetase activity (L-aspartate-adding)", "d": ["Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.117", "l": "\"stratum corneum chymotryptic enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755413", "l": "SARS-CoV-2 8 binds IL17RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034738", "l": "lanosterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73254", "l": "cirsimaritin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852019", "l": "MET bound PI3K generates PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40971", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13999", "l": "2-methylpropanoyl-CoA + CO2 + NADH => 3-methyl-2-oxobutanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371435", "l": "Constitutive phosphorylation by GSK3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54952", "l": "ATP + CoA + nonanoate = AMP + diphosphate + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25612", "l": "beta-D-allofuranose <=> beta-D-allopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38504", "l": "a 1,3-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62769", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22991", "l": "3-oxopropanoate + CoA + NADP(+) <=> acetyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65119", "l": "2-oxoglutarate + aculene B + O2 <=> aculene A + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032560", "l": "guanyl deoxyribonucleotide binding", "d": ["Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013147", "l": "RAC1 GDIs block activation of RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25447", "l": "(2E,6E)-farnesyl diphosphate <=> (1E,4E)-germacrene B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.83", "l": "\"kappa-carrageenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177922", "l": "EGFR dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801776", "l": "REG3A binds bacterial phospholipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58022", "l": "eupatolide + H2O => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41021", "l": "1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40610", "l": "1-tetradecanoyl-sn-glycerol + H2O <=> glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863014", "l": "p25-bound CDK5 phosphorylates CDC25A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39161", "l": "(2E)-hexadecenoyl-CoA + H2O => (3R)-hydroxyhexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32041", "l": "AMP + ATP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003935", "l": "GTP cyclohydrolase II activity", "d": ["Catalysis of the reaction: GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047615", "l": "actinomycin lactonase activity", "d": ["Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35162", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47611", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34045", "l": "5''-phosphoribostamycin + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + neamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75941", "l": "4-guanidinobutanoate + L-ornithine => 4-aminobutanoate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097162", "l": "MADS box domain binding", "d": ["Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879930", "l": "STAT5 is recruited by JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68513", "l": "(2Z,6Z)-farnesyl diphosphate => alpha-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59471", "l": "an S-substituted glutathione + H2O <=> an S-substituted L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928646", "l": "EPHAs bind EFNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19622", "l": "a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002135", "l": "CTP binding", "d": ["Binding to CTP, cytidine 5'-triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198756", "l": "ERK1/2 phosphorylates MSK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70190", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose <=> cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63101", "l": "H(+) + ilicicolin C + NADPH + O2 => ascochlorin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.6", "l": "\"carboxypeptidase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318415", "l": "ATF2 acetylates histone H2B, H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35004", "l": "L-fucose(in) => L-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050585", "l": "4-hydroxymandelate synthase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685608", "l": "CLEC2B binds KLRF1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368279", "l": "MTIF3 binds 28S ribosomal subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44085", "l": "ATP + CoA + heptadecanoate => AMP + diphosphate + heptadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010643", "l": "AKAP5 recruits PKC to ROBO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65976", "l": "7-dehydrocholesterol + hnu = previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004493", "l": "methylmalonyl-CoA epimerase activity", "d": ["Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18289", "l": "(S,S)-tartrate = H2O + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.2.1.81", "l": "\"D(-)-tartrate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211224", "l": "Association of DFF40 with DFF45 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65633", "l": "a sphingoid base + tetracosanoyl-CoA => an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61995", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140937", "l": "histone H4K12 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665871", "l": "ADRM1 binds 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209566", "l": "TRAF6 is auto-ubiquitinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30903", "l": "demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": [], "t": []}, {"i": "EC:2.1.1.210", "l": "\"demethylspheroidene O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53392", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] = (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.54", "l": "\"phenylacetate 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55520", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + nerylneryl diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.142", "l": "\"nerylneryl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949399", "l": "CAR translocates from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17429", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate = 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.226", "l": "\"4-hydroxycyclohexanecarboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57598", "l": "(2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433456", "l": "Recruitment of STATs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.33", "l": "\"polynucleotide 5'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358519", "l": "MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61559", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58962", "l": "benzoate + H(+) + H2O2 => benzaldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45734", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627089", "l": "CASP9 is phosphorylated at T412 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.4", "l": "\"serine-type D-Ala-D-Ala carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013006", "l": "RHOA:GTP translocates to the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55265", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48243", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17663", "l": "ADP + phosphate + succinyl-CoA => ATP + CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935740", "l": "RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23551", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63827", "l": "2 3-(4-hydroxyphenyl)pyruvate <=> aspulvinone E + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64471", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43518", "l": "2-carboxy-5-(dihydroxymethyl)furan => 2-carboxy-5-formylfuran + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30196", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357479", "l": "p-AXL binds PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18792", "l": "D-glucosamine 6-phosphate <=> D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353271", "l": "Cleavage of uracil by Uracil-glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12941", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.143", "l": "\"alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034862", "l": "2,6-dihydroxybenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989772", "l": "Expression of GLIPR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000215", "l": "tRNA 2'-phosphotransferase activity", "d": ["Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047382", "l": "methylphosphothioglycerate phosphatase activity", "d": ["Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H2O = S-methyl-1-thio-D-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004654", "l": "polyribonucleotide nucleotidyltransferase activity", "d": ["Catalysis of the reaction: RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070287", "l": "ferritin receptor activity", "d": ["Combining with ferritin, and delivering ferritin into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77691", "l": "a ganglioside GD1b (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GD1b (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67789", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44818", "l": "2-demethylmenaquinol-12 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295632", "l": "PPA2A dephosphorylates SPRY2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2301205", "l": "SETD8 monomethylates histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047875", "l": "ecdysone oxidase activity", "d": ["Catalysis of the reaction: Ecdysone + O2 = 3-dehydroecdysone + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75087", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58382", "l": "H(+) + NADPH + nonanal => NADP(+) + nonan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211247", "l": "Cleavage of DNA by DFF40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76430", "l": "(2R,9S)-annullatin H + A <=> (2R)-annullatin F + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015425", "l": "ATPase-coupled nonpolar-amino acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12458", "l": "CDP-L-ribitol + diphosphate => CTP + D-ribitol 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71770", "l": "2 Fe(2+) + H(+) + NADP(+) <=> 2 Fe(3+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-994148", "l": "LRRC16A binds F-actin capping protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51844", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036463", "l": "TRAIL receptor activity", "d": ["Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798474", "l": "S100A8:S100A9 binds Zn2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139918", "l": "Phosphorylation of BIM by JNK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11024", "l": "ATP + NH4(+) = ADP + 2 H(+) + phosphoramidate", "d": [], "t": []}, {"i": "EC:2.7.3.8", "l": "\"ammonia kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43371", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388814", "l": "Grb2 binds CD28 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420131", "l": "The PACAP receptor binds PACAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944261", "l": "Association of procollagen type XIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21867", "l": "an S-(2-hydroxyacyl)glutathione + H2O <=> a 2-hydroxy carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186765", "l": "PLC-gamma binds to the active receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635843", "l": "GLI translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21589", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37379", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011598", "l": "DOCKs bind to RhoGEFs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811508", "l": "ING2-bound EP300 acetylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209245", "l": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445069", "l": "L1-EGFR trans-heterodimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62851", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.360", "l": "\"glucose/galactose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3209165", "l": "ID1 sequesters ETS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67025", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70761", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42254", "l": "3-oxoheptanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60160", "l": "ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038022", "l": "G protein-coupled olfactory receptor activity", "d": ["Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74938", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 <=> (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44427", "l": "a fatty acyl-CoA + heptadecasphing-4-enine <=> CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72175", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45556", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321883", "l": "MSL acetylates histone H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425861", "l": "Activation of Protein Kinase C novel isoforms (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62670", "l": "H2O + herqueinone + NADP(+) => deoxyherqueinone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446364", "l": "Migfilin interacts with VASP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.154", "l": "\"fructan beta-(2,6)-fructosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50438", "l": "prostaglandin E1 => prostaglandin H1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0086006", "l": "voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754974", "l": "ADK phosphorylates RBV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27389", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = pyruvate + salicylaldehyde", "d": [], "t": []}, {"i": "EC:4.1.2.45", "l": "\"trans-o-hydroxybenzylidenepyruvate hydratase-aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699163", "l": "Defective BARD1 does not bind BRCA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696997", "l": "USP24 deubiquitinates DDB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45101", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine => mitomycin B + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51541", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9705584", "l": "HMGCR dimer binds statins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74793", "l": "(R)-salsolinol(out) => (R)-salsolinol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77643", "l": "adenosine 2',5'-bisphosphate + H2O = AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77068", "l": "Activation of GT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29738", "l": "butane-1-sulfonate + FMNH2 + O2 <=> butanal + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265177", "l": "Exocyst complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57286", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA => a guanosine in RNA + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757097", "l": "SARS-CoV-2 N binds NLRP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0052856", "l": "NADHX epimerase activity", "d": ["Catalysis of the reaction: (R)-NADHX = (S)-NADHX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209076", "l": "SPZ dimer bound TL dimerises at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72614", "l": "H(+)(out) + L-alanyl-L-lysine(out) <=> H(+)(in) + L-alanyl-L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17052", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24842", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66052", "l": "indole-3-pyruvate + L-kynurenine = H2O + kynurenate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69660", "l": "H2O + kaempferol 3-O-beta-D-glucoside => beta-D-glucose + kaempferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202203", "l": "Recruitment of PI3K to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17834", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine => 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662986", "l": "MT2A binds copper (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63818", "l": "AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15240", "l": "2 Fe(III)-[cytochrome c2] + NADPH <=> 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14116", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112434", "l": "Formation of DSIF complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40097", "l": "2 H(+) + hexacosanedioate + NADH => 26-oxohexacosanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52424", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134954", "l": "DHX9 binds DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036370", "l": "D-alanyl carrier activity", "d": ["Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811479", "l": "ING2 recruits EP300 to TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840401", "l": "DELE1(143-515) is released into the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56021", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446364", "l": "Migfilin interacts with VASP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67500", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052716", "l": "hydroquinone:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70808", "l": "4-deoxy-4-sulfo-D-erythrose => 4-deoxy-4-sulfo-D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38652", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050100", "l": "methylitaconate delta-isomerase activity", "d": ["Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19600", "l": "H2O + L-arginine <=> L-citrulline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52474", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76392", "l": "glycylglycylglycine(out) + n H(+)(out) => glycylglycylglycine(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130194", "l": "ABL phosphorylates WAVEs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28100", "l": "AMP + guanosine 3',5'-bis(diphosphate) => ATP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12926", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18508", "l": "L-lysine + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57425", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] => catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202233", "l": "Inactivation of Lck by Csk (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209255", "l": "UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63861", "l": "(9Z,12Z)-octadecadienoate + O2 => (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51698", "l": "H(+) + S-adenosyl-L-homocysteine + xanthohumol => desmethylxanthohumol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12251", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate <=> H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46939", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39425", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77446", "l": "a ganglioside GT3 + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GT2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622129", "l": "FABP5 binds atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805981", "l": "HMGB1 release from cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55066", "l": "4-methylpentanoate + CoA + H(+) => 4-methylpentanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28850", "l": "Li(+)(in) + melibiose(in) <=> Li(+)(out) + melibiose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443783", "l": "Interaction of NUMB with L1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63673", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48777", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987043", "l": "IL22RA1 binds JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26179", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine <=> 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034937", "l": "perchlorate reductase activity", "d": ["Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64609", "l": "L-threonyl-[protein] + UTP => diphosphate + uridylyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42156", "l": "androsterone + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209302", "l": "Phosphorylated BSK kinase dissociates from CKA scaffolding protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64529", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14951", "l": "2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2 => A + H2O + quinoline-4-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69810", "l": "benzoyl-AMP + CoA <=> AMP + benzoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098616", "l": "selenate adenylyltransferase (ATP) activity", "d": ["Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate."], "t": []}, {"i": "REACT:R-HSA-2408525", "l": "H2SeO4 is converted to APSe by PAPSS1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201608", "l": "Caspase-mediated cleavage of alpha adducin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694409", "l": "Nucleotide exchange on RAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72943", "l": "2 Na(+)(out) + pyruvate(out) = 2 Na(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15466", "l": "ATP + sphinganine => ADP + H(+) + sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106375", "l": "deoxynucleoside triphosphate hydrolase activity", "d": ["Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate."], "t": []}, {"i": "RHEA:46148", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43033", "l": "3-chloro-D-alanine => 2-aminoprop-2-enoate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728697", "l": "GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11018", "l": "(S)-ureidoglycolate + urea => allantoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201603", "l": "Caspase-mediated cleavage of PKC theta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53324", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28386", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36952", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 => (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11328", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.28", "l": "\"dimethylallylcistransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32961", "l": "(S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-isoleucine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65931", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28825", "l": "H(+)(out) + L-galactonate(out) => H(+)(in) + L-galactonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10287", "l": "L-leucine <=> (3R)-beta-leucine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014433", "l": "RHOG GEFs activate RHOG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850794", "l": "SPINK6 binds KLK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009678", "l": "diphosphate hydrolysis-driven proton transmembrane transporter activity", "d": ["Catalysis of the reaction: diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65727", "l": "2-oxoglutarate + O2 + pentyl sulfate <=> CO2 + H(+) + pentanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25409", "l": "ADP-alpha-D-glucose + D-glucose => ADP + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70256", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57915", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) <=> H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006873", "l": "IL21 receptor STAT binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31155", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58108", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004793", "l": "threonine aldolase activity", "d": ["Catalysis of the reaction: L-threonine = glycine + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64714", "l": "H(+) + NADPH + propanal => 1-propanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005019", "l": "platelet-derived growth factor beta-receptor activity", "d": ["Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019771", "l": "high-affinity IgG receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980112", "l": "Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27709", "l": "ATP + D-alanine + D-serine <=> ADP + D-alanyl-D-serine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483219", "l": "PC is exchanged with PI by PITPNB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47675", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76192", "l": "carnosine(out) + 2 H(+)(out) => carnosine(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110153", "l": "RNA NAD-cap (NMN-forming) hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+."], "t": []}, {"i": "RHEA:60876", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373147", "l": "succinate + FAD <=> fumarate + FADH2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75172", "l": "GTP + NAD(+) => GDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57361", "l": "H2O + NADH => (6R)-NADHX", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16168", "l": "L-tryptophan + O2 <=> CO2 + H2O + indole-3-acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31374", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140080", "l": "class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15156", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose <=> 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71515", "l": "hypoxanthine(out) = hypoxanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392263", "l": "AVP(20-28) binds AVPR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010503", "l": "HOXA2 binds ROBO2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74885", "l": "GUCYs converts GTP to cGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10841", "l": "H2O + O-phospho-L-homoserine => L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18771", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008771", "l": "[citrate (pro-3S)-lyase] ligase activity", "d": ["Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58581", "l": "dihydroprecondylocarpine acetate => acetate + catharanthine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47759", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467811", "l": "Separation of sister chromatids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58568", "l": "15alpha-stemmadenine + acetyl-CoA = CoA + O-acetyl-15alpha-stemmadenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12874", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) => 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.-", "l": "\"Intramolecular lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26338", "l": "L-homocysteine + S-methyl-L-methionine => H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74052", "l": "D-threonine(out) + L-alanine(in) => D-threonine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444572", "l": "Zinc is an agonist of GPR39 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004507", "l": "steroid 11-beta-monooxygenase activity", "d": ["Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46169", "l": "ATP + CoA + pentanoate => AMP + diphosphate + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622310", "l": "Activated NOD1 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17262", "l": "an aryl sulfate + H2O => a phenol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50619", "l": "NADP(+) + nonan-2-one <=> (3E)-nonen-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034950", "l": "phenylboronic acid monooxygenase activity", "d": ["Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52936", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O = (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35455", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 = (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74660", "l": "N-acetyl-D-glucosamine + UTP => H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22281", "l": "O-demethylpuromycin + S-adenosyl-L-methionine => H(+) + puromycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211224", "l": "Association of DFF40 with DFF45 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52968", "l": "hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18444", "l": "D-dopachrome + H(+) <=> 5,6-dihydroxyindole + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43132", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.-.-", "l": "\"Catalysing the translocation of hydrons\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707827", "l": "Spike binds Spike inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47534", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => chenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47890", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031807", "l": "Protectins translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35344", "l": "3-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749647", "l": "CES2 hydrolyzes ASA- (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38025", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol => gamma-tocotrienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14068", "l": "scyllo-inosose <=> 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72995", "l": "L-fucose(out) + 2 Na(+)(out) = L-fucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39794", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14184", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 <=> (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55724", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676268", "l": "Formation of the MLL4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696958", "l": "USP44 deubiquitinates CDC20 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67813", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353273", "l": "Elongation by Pol zeta complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40292", "l": "ATP + CoA + tetradecanedioate => AMP + diphosphate + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695949", "l": "SPHK2 phosphorylates sphingoid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37894", "l": "aclacinomycin T + H2O <=> 15-demethylaclacinomycin T + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29204", "l": "dimethyl sulfoxide + menaquinol-8 => dimethyl sulfide + H2O + menaquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789092", "l": "NOX2 generates superoxide anion from oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65421", "l": "GMP(in) + NAD(+)(out) => GMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66984", "l": "3-methylbutanoyl-CoA + H2O = 3-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047489", "l": "pectate disaccharide-lyase activity", "d": ["Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10864", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052713", "l": "inositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984606", "l": "Kinesin-5 is a homotetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35279", "l": "acetyl-CoA + hexadecanoyl-CoA = 3-oxooctadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73757", "l": "Binding of RRN3 to RNA Polymerase I (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36027", "l": "CoA + NAD(+) + propanal = H(+) + NADH + propanoyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.1.87", "l": "\"propanal dehydrogenase (CoA-propanoylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55165", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 => H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090411", "l": "brassinosteroid binding", "d": ["Binding to a brassinosteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59627", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine <=> 4-aminobutanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18297", "l": "a phtalamide + H2O = a primary amine + phthalate", "d": [], "t": []}, {"i": "EC:3.5.1.79", "l": "\"phthalyl amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36207", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.938801239267953", "identifiers": [{"i": "GO:0015103", "l": "inorganic anion transmembrane transporter activity", "d": ["Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22811", "l": "6-hydroxynicotinate + H2O + O2 <=> 2,6-dihydroxynicotinate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047639", "l": "alcohol oxidase activity", "d": ["Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617927", "l": "FOXO4 binds ATXN3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033042", "l": "umami taste receptor activity", "d": ["Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68960", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine = 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55226", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.378039260235589", "identifiers": [{"i": "GO:0016462", "l": "pyrophosphatase activity", "d": ["Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups."], "t": []}, {"i": "REACT:R-HSA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849857", "l": "KLK5 cleaves and activates CELA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803989", "l": "Nitric oxide and O2 react to NO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983147", "l": "Release of E3 from polyubiquitinated substrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72399", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) = 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879281", "l": "mycothiol is cleaved to acetylcysteine and glucosaminylinositol (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013158", "l": "CDC42 GDIs block activation of CDC42 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042293", "l": "Hub1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769401", "l": "DKK and KRM bind LRP5/6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31434", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-beta-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.319", "l": "\"isoeugenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728150", "l": "SLC5A2 binds gliflozins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56241", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12432", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}, {"i": "EC:2.3.2.10", "l": "\"UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865275", "l": "PDGF-BB clevage by Furin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48586", "l": "2 lipoxin A4 => 2 H2O + 2 leukotriene A4 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008820", "l": "cobinamide phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68455", "l": "all-trans-10'-apo-beta-carotenal + O2 <=> 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46726", "l": "(2R)-2-methyltetradecanoyl-CoA => (2S)-2-methyltetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15745", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose = [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.9", "l": "\"inulosucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050190", "l": "phosphoglucokinase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41065", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69204", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850831", "l": "KLK5 cleaves and activates KLK8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54081", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49246", "l": "18-oxo-resolvin E1 + H(+) + NADH => NAD(+) + resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21503", "l": "UDP-alpha-D-glucose <=> H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210959", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66423", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54124", "l": "coelenterazine h dioxetanone = CO2 + excited coelenteramide h monoanion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37256", "l": "A + D-asparagine + H2O => 2-oxosuccinamate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53626", "l": "diphosphate + tsukubadiene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56984", "l": "(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977626", "l": "C4b-binding protein binds C4b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28257", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA <=> (3Z)-hex-3-en-1-yl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60986", "l": "16-oxohexadecanoate + H(+) + NADH => 16-hydroxyhexadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381091", "l": "IRE1 dimer autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28375", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55529", "l": "H(+) + H2O + L-tyrosine + O2 => (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39448", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647978", "l": "pro-RAS proteins are farnesylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38293", "l": "(S)-malate + CoA + H(+) => (S)-malyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10700", "l": "H2O + limonene 1,2-epoxide = limonene-1,2-diol", "d": [], "t": []}, {"i": "EC:3.3.2.8", "l": "\"limonene-1,2-epoxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11173", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine => (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034025", "l": "D-aspartate ligase activity", "d": ["Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607753", "l": "CARD9 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45050", "l": "acetate + NH4(+) => acetamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757954", "l": "N4BP1 binds IKBKG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57965", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54118", "l": "diphosphate + pseudolaratriene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63624", "l": "hexadecanoyl-AMP + holo-[ACP] = AMP + H(+) + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56866", "l": "(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+) => 12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51510", "l": "CO2 + succinate + trans-4-hydroxy-L-proline => 2-oxoglutarate + L-proline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693198", "l": "RHOD binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51740", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093332", "l": "p-EPHB phosphorylates SDC2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39652", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54064", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.175", "l": "\"10-epi-cubebol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23829", "l": "2-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31568", "l": "bisphenol A + H(+) + NADH + O2 => 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73327", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA = cimicifugate J + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202966", "l": "Caspase mediated cleavage of HIP-55 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61635", "l": "5-aminopentanal + H2O + NAD(+) <=> 5-aminopentanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72454", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) <=> a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16448", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone <=> daidzein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016697", "l": "oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome."], "t": []}, {"i": "EC:1.12.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83677", "l": "C4 deamination of cytidine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008934", "l": "inositol monophosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32394", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110307", "l": "REV1 binds AP-dsDNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29830", "l": "Mg(2+)(in) <=> Mg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36465", "l": "glycine + L-glutamate => glycyl-L-glutamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675866", "l": "PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.-", "l": "\"Phosphotransferases with regeneration of donors, apparently catalyzing intramolecular transfers\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63330", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(9Z-octadecenoyl)-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37492", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72087", "l": "2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) + taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694471", "l": "Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050127", "l": "N-carbamoylsarcosine amidase activity", "d": ["Catalysis of the reaction: N-carbamoylsarcosine + H2O + 2 H+ = CO2 + NH4 + sarcosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790022", "l": "Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76817", "l": "H(+) + NADH + NH4(+) + pyruvate => D-alanine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12945", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + H(+) + sulfite", "d": [], "t": []}, {"i": "EC:3.13.1.3", "l": "\"2'-hydroxybiphenyl-2-sulfinate desulfinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10740", "l": "a secondary alcohol + NAD(+) = a ketone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34933", "l": "glutathione + hydrogenselenide + NADP(+) => glutathioselenol + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674531", "l": "AAMP binds EGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41144", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50162", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956684", "l": "ITCH polyubiquitinates TP73 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72652", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64544", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine = 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702818", "l": "CALCR binds erenumab (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68148", "l": "2-octanone + H(+) + NADPH = (2R)-octan-2-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45697", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) => N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57558", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909721", "l": "Translocation of ISGF3 complex to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64372", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.97", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610726", "l": "The IFT-A complex recruits TULP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139893", "l": "Granzyme-B activates BID by cleavage (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12338", "l": "fumarate + glycolate => carboxymethoxysuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0004955", "l": "prostaglandin receptor activity", "d": ["Combining with a prostaglandin (PG) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58184", "l": "H(+) + NADPH + 2 phytyl diphosphate = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49399", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5669240", "l": "FLNA binds PAK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350578", "l": "NQO1 interaction with ODC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40758", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51923", "l": "a quinone + AH2 <=> A + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140580", "l": "mitochondrion autophagosome adaptor activity", "d": ["The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42206", "l": "11-dehydrocorticosterone + H(+) + NADH => corticosterone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34426", "l": "(-)-secoisolariciresinol + NADP(+) <=> (+)-lariciresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45951", "l": "acetyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800490", "l": "ATM phosphorylates PIDD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49610", "l": "2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH => 2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034282", "l": "ent-pimara-8(14),15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021334", "l": "STAT1 binds HEY1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205289", "l": "Autophosphorylation of KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19612", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31678", "l": "NADP(+) + raucaffrinoline <=> H(+) + NADPH + perakine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010997", "l": "anaphase-promoting complex binding", "d": ["Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46760", "l": "2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.14.12.24", "l": "\"2,4-dinitrotoluene dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54837", "l": "H(+) + heptan-2-one + NADPH + O2 => H2O + NADP(+) + pentyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626220", "l": "C2CD3 binds the mother centriole (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.135", "l": "\"N(4)-acetylcytidine amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16531", "l": "adenosine 5'-phosphosulfate + phosphate => ADP + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687097", "l": "p-S857 NCOA3 binds ETV4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74492", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => yaequinolone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11657", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline => AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21991", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside <=> 4'''-demalonylsalvianin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201669", "l": "Beta-catenin translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939335", "l": "RNF181 polyubiquinates BCL10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24254", "l": "2 ADP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24613", "l": "17beta-estradiol + NAD(+) => estrone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57008", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 = 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77094", "l": "Formation of cap binding complex (CBC) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33344", "l": "glycine + O2 => 2-iminoacetate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013023", "l": "RHOB GEFs activate RHOB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67416", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68884", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH = 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13706", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine => alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247844", "l": "WNT ligands traffic to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54153", "l": "a uridine in rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749215", "l": "MCM8 binds CDC6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43542", "l": "ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase] => ATP + L-seryl-[isocitrate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.169", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48756", "l": "erythritol + NAD(+) = D-erythrulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65655", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008444", "l": "CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69611", "l": "H2O + kojibiose = beta-D-glucose + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.216", "l": "\"kojibiose hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63515", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.2", "l": "\"lysoplasmalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:0016880", "l": "acid-ammonia (or amide) ligase activity", "d": ["Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13459", "l": "CO2 + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] => 3-methyl-2-oxobutanoate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76982", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031730", "l": "CCR5 chemokine receptor binding", "d": ["Binding to a CCR5 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47793", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2169046", "l": "Degradation of TGF-beta receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840408", "l": "OMA1 cleaves DELE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12841", "l": "pyridoxamine + pyruvate = L-alanine + pyridoxal", "d": [], "t": []}, {"i": "EC:2.6.1.30", "l": "\"pyridoxamine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32539", "l": "(2E)-geranyl diphosphate = (+)-car-3-ene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.107", "l": "\"(+)-car-3-ene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68845", "l": "(2Z,6E)-farnesyl diphosphate => (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5195402", "l": "CDK1 phosphorylates LPIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990601", "l": "5' overhang single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391158", "l": "SIRP alpha binds CD47 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35841", "l": "a cardiolipin + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14286", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019874", "l": "6-aminohexanoate-cyclic-dimer hydrolase activity", "d": ["Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936963", "l": "IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41756", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43080", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56344", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose = a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44438", "l": "a triacylglycerol + glycerol => a 1,2-diacylglycerol + a 1-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67268", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210972", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16894", "l": "pyridine + S-adenosyl-L-methionine => N-methylpyridinium + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661188", "l": "Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30447", "l": "3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034865", "l": "2,4,4-trimethylpentanoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354060", "l": "Translocation of RIAM to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70480", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) => 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61723", "l": "a D-guloside + NAD(+) <=> a 3-dehydro-D-guloside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68249", "l": "L-tyrosine(in) + Na(+)(in) => L-tyrosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77475", "l": "acetyl-CoA + tetrahydroanabasine = ammodendrine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156930", "l": "GTP-binding activates eEF2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38067", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.280", "l": "\"(aminoalkyl)phosphonate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73039", "l": "H(+)(out) + Ni(2+)(out) = H(+)(in) + Ni(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204873", "l": "Interaction of Tie2 and Shp2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44122", "l": "CoA + octadecanyl hexadecanoate => hexadecanoyl-CoA + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579081", "l": "Defective ACY1 does not hydrolyse mercapturic acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.176141984063477", "identifiers": [{"i": "GO:0042887", "l": "amide transmembrane transporter activity", "d": ["Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51433", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA => [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209244", "l": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848606", "l": "PTK6 phosphorylates PXN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173636", "l": "Formation of classic pathway C5 convertase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050300", "l": "aminoglycoside 6-kinase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351208", "l": "Spermidine  => N-acetylated spermidine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865182", "l": "OTUD7A hydrolyses K11diUb (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4837364", "l": "Secretion of SOD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45069", "l": "(R)-carnitine + an acyl-CoA => CoA + O-acyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678998", "l": "Endosomal TLRs pass through the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167128", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42519", "l": "H2O + L-gulono-1,4-lactone <=> H(+) + L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983147", "l": "Release of E3 from polyubiquitinated substrate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55812", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18465", "l": "L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.30", "l": "\"stizolobinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25379", "l": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18629", "l": "ATP + NAD(+) = ADP + H(+) + NADP(+)", "d": [], "t": []}, {"i": "EC:2.7.1.23", "l": "\"NAD(+) kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58179", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103118", "l": "UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity", "d": ["Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] = UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45817", "l": "(S)-lactate + A => AH2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061788", "l": "EGF repeat binding", "d": ["Binding to Epidermal Growth Factor (EGF) repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046570", "l": "methylthioribulose 1-phosphate dehydratase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67478", "l": "diphosphate + prekainate => dimethylallyl diphosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36887", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11551", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52482", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65941", "l": "(R)-glycerate + GDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53022", "l": "a 2-oxocarboxylate + a plastoquinol + NH4(+) => a plastoquinone + an L-alpha-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51773", "l": "dimethylallyl diphosphate + phlorisobutanophenone => 4-prenylphlorisobutanophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43528", "l": "L-serine + NAD(+) = 2-aminomalonate semialdehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48811", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437084", "l": "ZnT3 transports zinc into synaptic vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40807", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13150", "l": "A + H(+) + NADPH => AH2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75241", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein] => acetyl-CoA + N-terminal L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13885", "l": "H2O + stipitatonate = CO2 + stipitatate", "d": [], "t": []}, {"i": "EC:4.1.1.60", "l": "\"stipitatonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37321", "l": "ADP + glycyl-L-methionine(in) + H(+) + phosphate => ATP + glycyl-L-methionine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67784", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050637", "l": "lovastatin nonaketide synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026771", "l": "DPEP hydrolyses MCTR2 to MCTR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22601", "l": "H2O + N-acetyl-9-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26154", "l": "6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50629", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 3-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70267", "l": "hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002173", "l": "low-affinity IgM receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16594", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine => 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46687", "l": "3-oxochol-4-en-24-oyl-CoA + A <=> (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634430", "l": "IL6R gene expression is enhanced by CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424484", "l": "Phosphorylation of BTK by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467761", "l": "A2E is phagocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60983", "l": "12-hydroxydodecanoate + NAD(+) <=> 12-oxododecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55200", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.147", "l": "\"5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70271", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37758", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062063", "l": "BBSome binding", "d": ["Binding to a BBSome complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004727", "l": "prenylated protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799332", "l": "ATR phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69454", "l": "3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.5", "l": "\"xylose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018756", "l": "RHOH binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52641", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44491", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948641", "l": "miR-106 microRNAs bind VAPA mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.18", "l": "\"dimethylargininase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52561", "l": "2-dehydro-D-erythronate => 3-dehydro-D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35364", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH => isopentadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74389", "l": "formamide(in) => formamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36652", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine => H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682010", "l": "ATG10:ATG12 binds ATG5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694579", "l": "Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28428", "l": "keto-D-fructose 6-phosphate => D-allulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76347", "l": "(2R,3S)-3-isopropylmalate(in) + sulfate(out) = (2R,3S)-3-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10739", "l": "a primary alcohol + NAD(+) <=> an aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614185", "l": "Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52738", "l": "(Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+) => (Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018365", "l": "protein-serine epimerase activity", "d": ["Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56299", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] <=> pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69853", "l": "a uridine in mRNA + H(+) + NADH => a 5,6-dihydrouridine in mRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606345", "l": "Recruitment of IRF3 to activated ZBP1:TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27427", "l": "(E)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43505", "l": "5-hydroxymethylfurfural + O2 => 2,5-diformylfuran + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19153", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose = 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.25", "l": "\"flavone apiosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66050", "l": "(2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate => 2-oxobutanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32570", "l": "(2E)-geranyl diphosphate <=> (1R,4S)-camphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22403", "l": "androstan-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxyandrostanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68204", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA = 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851933", "l": "MET phosphorylates GAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15875", "l": "[(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+) => [(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16804", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] <=> adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102678", "l": "22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity", "d": ["Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP = H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0070186", "l": "growth hormone activity", "d": ["The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019911", "l": "structural constituent of myelin sheath", "d": ["The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876472", "l": "NPC2 binds CHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39190", "l": "(3R)-hydroxydocosanoyl-CoA <=> (2E)-docosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217209", "l": "Generation of a DNA double strand break (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015111", "l": "Factor Xa inhibitors binds Xa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008710", "l": "8-amino-7-oxononanoate synthase activity", "d": ["Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38156", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (6E,10E)-geranyllinalool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139918", "l": "Phosphorylation of BIM by JNK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51100", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047815", "l": "D-arabinonolactonase activity", "d": ["Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004117", "l": "calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin."], "t": []}, {"i": "REACT:R-HSA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534388", "l": "Progesterone Activation Of CatSper (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772430", "l": "CTNNBIP1 binds beta-catenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69734", "l": "CoA + phenylacetyl-AMP <=> AMP + H(+) + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76148", "l": "perivine + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + vobasine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706837", "l": "AR binds AR antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0019152", "l": "acetoin dehydrogenase activity", "d": ["Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60686", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49885", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10611", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48001", "l": "1,6-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71666", "l": "a menaquinone + 2 H(+)(out) + succinate <=> a menaquinol + fumarate + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39622", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH <=> (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27789", "l": "2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700656", "l": "alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40901", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36300", "l": "(E)-caffeate + ATP + CoA => (E)-caffeoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805811", "l": "Release of SEPT4 from mitochondria (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60102", "l": "cyanidin 3-O-beta-D-glucoside + H(+) + UDP => cyanidin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878212", "l": "JAG1 gene expression is inhibited by RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416690", "l": "SEMA4A binds to PLXND1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853801", "l": "PSPN binds RET:GFRA4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50609", "l": "leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39227", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH = NADP(+) + octacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33436", "l": "fecosterol => episterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954056", "l": "E2F6 binds TFDP2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13061", "l": "O2 + S-sulfanylglutathione = glutathione S,S-dioxide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40725", "l": "(9E)-octadecenoate + CoA + H(+) => (9E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174235", "l": "Association of Emi1 with Cdc20 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432121", "l": "LDL binds to LRP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654515", "l": "KAL1 binds HS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22071", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936563", "l": "ISGylation of DDX58 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36570", "l": "GDP-beta-L-colitose + NAD(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112437", "l": "Formation of NELF complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24792", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24250", "l": "glycine + pyruvate => glyoxylate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13865", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.142", "l": "\"chitobiosyldiphosphodolichol beta-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534096", "l": "METAP1/2 demethylates GNAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24200", "l": "4-aminobenzoate + H(+) = aniline + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57467", "l": "(E)-caffeate + UDP-alpha-D-glucose <=> 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43320", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005111", "l": "type 2 fibroblast growth factor receptor binding", "d": ["Binding to a type 2 fibroblast growth factor receptor (FGFR2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50459", "l": "prostaglandin H3 <=> prostaglandin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938853", "l": "CDK6 binds RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102941", "l": "3,5-dihydroxyanisole O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53575", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20436", "l": "NAD(+) + xylitol <=> D-xylulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008054", "l": "IL1F10 binds IL1RAPL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16454", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O => 2-formylbenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.21", "l": "\"rhizopuspepsin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034824", "l": "citronellyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57527", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59643", "l": "D-xylotetraose + O2 <=> D-xylotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29305", "l": "2 H(+)(out) + succinate(out) => 2 H(+)(in) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72908", "l": "D-mannose(out) + Na(+)(out) => D-mannose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129357", "l": "Fibrillin C-terminal processing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16805", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.26", "l": "\"deacetoxycephalosporin-C hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22721", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60303", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45760", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66301", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0098847", "l": "sequence-specific single stranded DNA binding", "d": ["Binding to single-stranded DNA of a specific nucleotide composition."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22343", "l": "3-hydroxybenzyl alcohol + NADP(+) <=> 3-hydroxybenzaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16045", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633742", "l": "EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60558", "l": "pseudouridine(35) in tRNA(Tyr) => uridine(35) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73763", "l": "2 ATP + L-alanine + L-tryptophan = 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811454", "l": "MAPKs phosphorylate PP2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24376", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": [], "t": []}, {"i": "EC:6.3.4.11", "l": "\"biotin--[methylcrotonoyl-CoA-carboxylase] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042500", "l": "aspartic endopeptidase activity, intramembrane cleaving", "d": ["Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010190", "l": "ROBO3 binds NELL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74060", "l": "beta-alanine(out) + L-alanine(in) => beta-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32156", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine => adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51156", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12822", "l": "2-deoxy-D-ribose 5-phosphate => acetaldehyde + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.007505823603481", "identifiers": [{"i": "GO:0008395", "l": "steroid hydroxylase activity", "d": ["Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205244", "l": "Recruitment of CBL to KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58427", "l": "(E)-hex-2-en-1-ol + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983307", "l": "IL15 binds IL15RA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848023", "l": "Activated PTK6 binds STAP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205118", "l": "TRAF6 polyubiquitinates NRIF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.41", "l": "\"(E)-2-methylbutanal oxime monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734713", "l": "ORC6 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20749", "l": "2-oxoglutarate + O2 + penicillin N => CO2 + deacetoxycephalosporin C + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17727", "l": "2-methyl-cis-aconitate + H2O => (2S,3S)-2-methylcitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380272", "l": "Plk1-mediated phosphorylation of Nlp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614544", "l": "Sulfite is oxidized to sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20970", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14179", "l": "(R)-prunasin + D-glucose => (R)-amygdalin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28215", "l": "[thioredoxin]-dithiol + prostaglandin H2 => [thioredoxin]-disulfide + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73400", "l": "D-aspartate(in) + sulfate(out) => D-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854408", "l": "APOBR dimer binds VLDLs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042015", "l": "interleukin-20 binding", "d": ["Binding to interleukin-20."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011083", "l": "ROBO1 gene expression is inhibited by LHX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75990", "l": "a dicarboxylate(in) + indoxyl sulfate(out) <=> a dicarboxylate(out) + indoxyl sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047442", "l": "17-alpha-hydroxyprogesterone aldolase activity", "d": ["Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008349", "l": "MAP kinase kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14332", "l": "2-oxoglutarate + O-phospho-L-serine <=> 3-phosphooxypyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58587", "l": "dihydroprecondylocarpine acetate <=> (-)-tabersonine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611368", "l": "CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683925", "l": "ULK1 is dephosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70841", "l": "L-arginine(out) + L-histidine(in) + Na(+)(in) => L-arginine(in) + L-histidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59966", "l": "CoA + O-octanoyl-L-seryl-[protein] => L-seryl-[protein] + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005308", "l": "creatine transmembrane transporter activity", "d": ["Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56044", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": [], "t": []}, {"i": "EC:3.2.1.210", "l": "\"endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68173", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 => CO2 + H2O + isodomoate A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48311", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O <=> (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993781", "l": "Conjugation of SUMO3 to UBA2:SAE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983158", "l": "Trimming of peptides in ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352059", "l": "SLC6A15-mediated amino acid uptake (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36699", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP = 8-desmethylnovobiocic acid + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.3.1.15", "l": "\"8-demethylnovobiocic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623355", "l": "ESR1-dependent CCND1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56863", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate <=> a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052815", "l": "medium-chain fatty acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: a medium-chain fatty acyl-CoA + H2O = a medium-chain fatty acid + CoA + H+. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658195", "l": "Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38446", "l": "a fatty acyl-CoA + a long chain fatty alcohol <=> a wax ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247513", "l": "STAB1:ligand is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48809", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39590", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820853", "l": "AGO2 binds maternal endosiRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30720", "l": "acetyl-CoA + propanoyl-CoA => 2-methyl-3-oxobutanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17562", "l": "acetylcholine + H2O => acetate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865693", "l": "BRWD1 gene expression is repressed by STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60083", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030754", "l": "apigenin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.8.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20826", "l": "ADP + AMP + H(+) => adenosine + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47846", "l": "CO2 + diphosphate + thiamine phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062045", "l": "L-lysine alpha-aminotransferase", "d": ["Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19748", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70011", "l": "2-aminobenzoyl-AMP + CoA = AMP + anthraniloyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76520", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] => (R)-lipoate + L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37607", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16809", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate", "d": [], "t": []}, {"i": "EC:4.1.3.30", "l": "\"methylisocitrate lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64830", "l": "3-hydroxy-benzyl acetate + CoA => 3-hydroxybenzyl alcohol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72323", "l": "3 Na(+)(out) + thiosulfate(out) = 3 Na(+)(in) + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67188", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395231", "l": "E2F1/3:DP1/2 binds NOTCH1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46816", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419011", "l": "Transhomodimerization of Nectins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173631", "l": "Activation of C1s (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49387", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093342", "l": "SDC2 multimerises (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196753", "l": "2xPPCS ligates PPanK with Cys (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60429", "l": "(indol-3-yl)acetyl-L-aspartate + H2O => (indol-3-yl)acetate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450533", "l": "PKCdelta phosphorylates HuR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43315", "l": "ATP + N-(hexanoyl)sphing-4-enine <=> ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16172", "l": "ATP + L-glutamate + NH4(+) <=> ADP + H(+) + L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29706", "l": "L-valine(in) <=> L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61910", "l": "2 AMP + asperphenamate + 2 diphosphate + H(+) => 2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858489", "l": "ppDVL binds DAAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40706", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399712", "l": "Activation of Ca permeable AMPA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031546", "l": "brain-derived neurotrophic factor receptor binding", "d": ["Binding to a brain-derived neurotrophic factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21821", "l": "L-homocysteine + S-adenosyl-L-methionine => H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183122", "l": "Factor D cleaves C3b-bound Factor B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964842", "l": "Shikimate results from hydration of DHS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159796", "l": "Furin cleaves pro-factor IX to factor IX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34504", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epi-alpha-bisabolol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61903", "l": "AH2 + betaenone C <=> A + betaenone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66191", "l": "3',5'-cyclic GMP(in) + ATP + H2O <=> 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24439", "l": "H2 + methanophenazine <=> dihydromethanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22102", "l": "3,5-dibromo-4-hydroxybenzoate + NH4(+) => 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250947", "l": "B-WICH complex binds rDNA promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46574", "l": "5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210881", "l": "Dimerization of Tie2/Ang1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102739", "l": "(gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate = H+ + gibberellin A4 + succinate + 2 carbon dioxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15729", "l": "D-mannonate + NAD(+) = H(+) + keto-D-fructuronate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874082", "l": "MET phosphorylates PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.176141984063477", "identifiers": [{"i": "GO:0042562", "l": "hormone binding", "d": ["Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36587", "l": "an aldopyranose + NADP(+) = aldono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034835", "l": "2-mercaptobenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902388", "l": "ceramide 1-phosphate transfer activity", "d": ["Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}, {"i": "REACT:R-HSA-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56696", "l": "D-ribulose 5-phosphate + L-tryptophan = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}, {"i": "EC:4.1.99.25", "l": "\"L-tryptophan isonitrile synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332359", "l": "Active calmodulin binds CAMK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111930", "l": "Adenylate cyclase produces cAMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709317", "l": "CO binds to free ferrohemoglobin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70061", "l": "a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41448", "l": "2-oxoglutarate + L-isoleucine + O2 = (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.45", "l": "\"L-isoleucine 4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32262", "l": "beta-D-fructose 1-phosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73807", "l": "GDP + S-adenosyl-L-methionine = N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848818", "l": "PTK6 phosphorylates CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74437", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in) => a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63736", "l": "2-phenylacetaldehyde + H(+) + NADPH = 2-phenylethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396124", "l": "AGRN binds Laminins with gamma-1 subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53230", "l": "16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69161", "l": "agmatine + H2O + O2 => H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28992", "l": "N-acetylneuraminate(in) => N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52248", "l": "6 H2O + 4 Mn(3+) + O2 = 12 H(+) + 4 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871265", "l": "YAP1 binds TEAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730843", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.-", "l": "\"With H2O2 as acceptor, one oxygen atom of which is incorporated into the product\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626928", "l": "CREBBP binds FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42138", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52175", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41261", "l": "(E)-3-(indol-3-yl)acrylate + NH4(+) => L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67821", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649856", "l": "Oxidative damage to the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75413", "l": "H(+) + lactenocin + S-adenosyl-L-homocysteine => demethyllactenocin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046175", "l": "Further sulfation on galactose residues produces KSPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64072", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA = 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.4", "l": "\"5a,11a-dehydrotetracycline reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22203", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51174", "l": "5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50020", "l": "decanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420233", "l": "VIP receptors bind VIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836606", "l": "SPHK1 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66950", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA => acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66729", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64882", "l": "CMP + H(+) + phosphate => CDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389350", "l": "Activation of Cdc42 by pVav1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621888", "l": "Defective HK1 does not phosphorylate Glc to form G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.8", "l": "\"flavin-containing monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749253", "l": "Formation of MCM2-7 complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33671", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O = 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21738", "l": "(3S,5S)-3,5-diaminohexanoate => (3S)-3,6-diaminohexanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27452", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10254", "l": "L-cysteine + phosphate => H(+) + hydrogen sulfide + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38778", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43994", "l": "16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13207", "l": "a UDP-monosaccharide + diphosphate => a monosaccharide 1-phosphate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102611", "l": "(+)-secoisolariciresinol monoglucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose = (+)-secoisolariciresinol diglucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14902", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => casbene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045508", "l": "interleukin-26 receptor activity", "d": ["Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20338", "l": "(R)-2-O-sulfolactate + H2O => (R)-lactate + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52141", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O => a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645428", "l": "ALPK1 binds ADP-heptose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20740", "l": "H2O + trans-2,3-epoxysuccinate = (2R,3S)-tartrate", "d": [], "t": []}, {"i": "EC:3.3.2.4", "l": "\"trans-epoxysuccinate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65298", "l": "ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] => (2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34730", "l": "H2O + N-acyl-15-methylhexadecasphinganine <=> 15-methylhexadecasphinganine + a carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167427", "l": "Opioid dissociates from MOR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.24", "l": "\"aromatic desulfoglucosinolate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52553", "l": "3-dehydro-L-erythronate + ATP => 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66682", "l": "ADP + coproporphyrinogen III(out) + H(+) + phosphate => ATP + coproporphyrinogen III(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18699", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 => 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49751", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NADP(+) + proviolacein", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333671", "l": "CLCAs self cleave (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912357", "l": "ITCH ubiquitinates DTX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162191", "l": "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35210", "l": "H2O + IDP <=> H(+) + IMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32494", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102601", "l": "cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + H+ + NADPH = 16beta-hydroxy-beta-amyrin + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14782", "l": "ATP + CoA + heptanedioate => 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001665", "l": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062240", "l": "euchromatin-nuclear membrane anchor activity", "d": ["Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71050", "l": "Trimerization of the FASL:FAS receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60438", "l": "3-methylbutanol + acetate + H(+) => 3-methylbutyl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20966", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33658", "l": "(9Z)-octadecenoate(out) <=> (9Z)-octadecenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44728", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662344", "l": "Defective HEXB does not cleave the terminal GalNAc from DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168888", "l": "Alpha1-Microglobulin binds heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72063", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) = glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086082", "l": "cell adhesive protein binding involved in AV node cell-bundle of His cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64666", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873850", "l": "STARD5 binds DCA, LCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42635", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15098", "l": "5-formimidoyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944236", "l": "Association of procollagen type XIV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655404", "l": "SUMOylation of AURKA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634219", "l": "NUP93 recruits the Nup62 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72097", "l": "(S)-carnitine(in) + Na(+)(in) => (S)-carnitine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51237", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) => GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19886", "l": "(S)-reticuline + O2 => (S)-scoulerine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939082", "l": "RUNX1 binds the CR1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694462", "l": "ABHD6,12 hydrolyse 3AG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19770", "l": "phaseollidin hydrate => H2O + phaseollidin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670433", "l": "KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44873", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23853", "l": "catechol + O2 => cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034432", "l": "bis(5'-adenosyl)-pentaphosphatase activity", "d": ["Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35345", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => 3-hydroxydocosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28342", "l": "dITP + H2O = dIMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31417", "l": "(+)-2-epi-prezizaene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36757", "l": "beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114553", "l": "Activation of conventional Protein Kinase C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430190", "l": "p-SLP-76 binds NCK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237160", "l": "MTA is cleaved and phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30401", "l": "alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676229", "l": "WIPIs bind PI3P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61577", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) => (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782234", "l": "Recovery of RNA synthesis after TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52637", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 => a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50784", "l": "dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0005338", "l": "nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380780", "l": "Activation of Src (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67411", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875183", "l": "CBL monoubiquitinates activated MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51140", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41604", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25797", "l": "2-oxoglutarate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977629", "l": "Displacement of C2a/Bb by CR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73561", "l": "dGTP(in) + UTP(out) => dGTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56452", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U", "d": [], "t": []}, {"i": "EC:5.5.1.32", "l": "\"12-epi-hapalindole U synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34310", "l": "4-nitrocatechol + NADPH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71226", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) <=> chloride(in) + 2 Na(+)(in) + taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72315", "l": "glutathione(in) + leukotriene C4(out) = glutathione(out) + leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54089", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428273", "l": "SPHK1 phosphorylates sphingoid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17901", "l": "S-adenosyl-L-methionine + xanthotoxol = H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16195", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38269", "l": "3-methylfumaryl-CoA => 2-methylfumaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48320", "l": "a ganglioside GA1 + GDP-beta-L-fucose = a ganglioside Fuc-GA1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851011", "l": "TRIM27 polyubiquitinates PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139917", "l": "tBID activates BAX protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047739", "l": "cephalosporin-C deacetylase activity", "d": ["Catalysis of the reaction: cephalosporin C + H2O = acetate + deacetylcephalosporin C + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75870", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] <=> 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.16", "l": "\"membrane Pro-Xaa carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624668", "l": "CEBPA binds CDKN1A (p21) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18184", "l": "acetyl-CoA + glyoxylate + H2O <=> (S)-malate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11901", "l": "(2R,3S)-homoisocitrate + NAD(+) => 2-oxoadipate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16003", "l": "IMP + methylamine => H(+) + H2O + N(6)-methyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48329", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52079", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951644", "l": "Release of mature NEDD8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106376", "l": "2-hydroxyphytanoyl-CoA lyase activity", "d": ["Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA."], "t": []}, {"i": "RHEA:25355", "l": "2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130194", "l": "ABL phosphorylates WAVEs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.64", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102528", "l": "7,8,4'-trihydroxyflavone methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone = H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44871", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol <=> 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781840", "l": "ERCC6 binds stalled RNA Pol II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52582", "l": "ADP + H(+) + Pb(2+)(out) + phosphate => ATP + H2O + Pb(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37374", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48860", "l": "18-HEPE + O2 = (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043814", "l": "phospholactate guanylyltransferase activity", "d": ["Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77473", "l": "(2S)-2-hydroxy-2-methylpentanenitrile => hydrogen cyanide + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37504", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691174", "l": "RAC1 binds effectors at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72260", "l": "L-dopa + S-adenosyl-L-methionine => 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58101", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O => (15Z)-tetracosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60831", "l": "a 5'-end triphospho-adenosine in mRNA + H2O <=> a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102713", "l": "gibberellin A25 hydroxylase activity", "d": ["Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 = gibberellin A46 + succinate(2-) + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16218", "l": "H2O + L-arabinono-1,4-lactone => H(+) + L-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174731", "l": "Degradation of newly synthesized ApoB-48 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25012", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944263", "l": "Association of procollagen type II (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44604", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990310", "l": "type-III dockerin domain binding", "d": ["Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691154", "l": "HFE binds TFRC dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106361", "l": "protein-arginine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-[protein]."], "t": []}, {"i": "RHEA:66692", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57930", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22208", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63289", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38647", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029454", "l": "Autophosphorylation of PAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46746", "l": "ADP + carboxyphosphate => ATP + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16120", "l": "acetoacetate + ATP + CoA <=> acetoacetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44094", "l": "AMP + diphosphate + nonadecanoyl-CoA => ATP + CoA + nonadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30638", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000310", "l": "xanthine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683769", "l": "O-glycosylation of 3a is terminated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168886", "l": "Hemopexin binds Hemes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28983", "l": "nitrite(in) = nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696131", "l": "AOC1 deaminates Hist (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53207", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944214", "l": "Association of procollagen type I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74710", "l": "fumagillol + NADP(+) <=> 5-dehydrofumagillol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26111", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}, {"i": "EC:4.2.1.115", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (inverting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68765", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42664", "l": "alpha-L-arabinopyanose + NADP(+) = H(+) + L-arabinono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73070", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O <=> an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030591", "l": "2'-deoxyguanosine DNA ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070611", "l": "histone H3R2 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to the arginine residue at position 2 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216045", "l": "Collagen type I binds integrin alpha11beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46748", "l": "carboxyphosphate + NH4(+) = carbamate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48402", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] => 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654511", "l": "FGFRL1 dimer binds FGFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73751", "l": "(R)-adrenaline(in) + 2 H(+)(out) = (R)-adrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158860", "l": "SULT1A1 dimer sulfonates NHABP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102382", "l": "rebaudioside B glucosyltransferase activity", "d": ["Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73302", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) <=> (S)-malate(in) + H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62999", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O <=> (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58073", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH => a jasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41566", "l": "aclacinomycin T + dTDP + 2 H(+) => aklavinone + dTDP-beta-L-rhodosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672973", "l": "MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68145", "l": "ethyl 3-oxobutanoate + H(+) + NADPH => ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000810", "l": "diacylglycerol diphosphate phosphatase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691004", "l": "XPC binds RAD23 and CETN2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35006", "l": "L-fucose(in) <=> L-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112392", "l": "Resumption of elongation after recovery from pausing (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64879", "l": "H2O + UDP <=> H(+) + phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62707", "l": "glycyldehydrophenylalanine + H2O <=> 2,3-didehydrophenylalanine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77190", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35588", "l": "FMN + H2O => phosphate + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25017", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.67", "l": "\"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032778", "l": "P-type cobalt transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)."], "t": []}, {"i": "RHEA:32779", "l": "ATP + Co(2+)(out) + H2O = ADP + Co(2+)(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102214", "l": "omega-hydroxy fatty acyl-CoA synthetase activity", "d": ["Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.363", "l": "\"ginsenoside 20-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28456", "l": "N(6)-(D-fructosyl)-L-lysine(out) => N(6)-(D-fructosyl)-L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783530", "l": "gp130:JAKs bind CNTFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34873", "l": "methanol(in) => methanol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17145", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.51", "l": "\"2'-hydroxydaidzein reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75993", "l": "a dicarboxylate(out) + N-benzoylglycine(in) => a dicarboxylate(in) + N-benzoylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41583", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate <=> 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805638", "l": "KAT6A acetylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0050308", "l": "sugar-phosphatase activity", "d": ["Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809764", "l": "SBF1 binds MTMR2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15548", "l": "(3S)-citramalate <=> acetate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10735", "l": "ATP + firefly D-luciferin + O2 <=> AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23897", "l": "5-dehydro-4-deoxy-D-glucuronate => 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32417", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2S,4R)-isodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010539", "l": "SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12410", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+) => L-lysine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429441", "l": "SYK activation by SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165179", "l": "Formation of TSC1:TSC2 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794347", "l": "Homer1,2,3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41819", "l": "a ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727819", "l": "TAK1 phosphorylates MKK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43053", "l": "3-(methylsulfanyl)propanoate + ATP + CoA => 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.-", "l": "\"Other lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186785", "l": "PDGF-AA clevage by Furin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693111", "l": "RHOF auto-activates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35970", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67857", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009924", "l": "octadecanal decarbonylase activity", "d": ["Catalysis of the reaction: octadecanal = heptadecane + CO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021068", "l": "PalmS-ESRs bind CAVs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000327", "l": "PLK1 phosphorylates BORA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62616", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099130", "l": "estrogen binding", "d": ["Binding to an estrogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008456", "l": "CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27984", "l": "7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate => 7-carboxy-7-deazaguanine + ATP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033921", "l": "capsular-polysaccharide endo-1,3-alpha-galactosidase activity", "d": ["Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050360", "l": "tryptophan 2'-dioxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64031", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12450", "l": "(R)-pantoate + beta-alanine => (R)-pantothenate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67000", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisobutanophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15835", "l": "4-hydroxybenzaldehyde + CO2 + H2O2 => (S)-4-hydroxymandelate + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.28", "l": "\"phenylethanolamine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77077", "l": "Capping complex formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56322", "l": "an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP => a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853921", "l": "VENTX stimulates p16-INK4A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052665", "l": "tRNA (uracil-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654514", "l": "KAL1 binds FGFR1c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047399", "l": "glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23220", "l": "4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.33", "l": "\"4-chlorobenzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47756", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0031795", "l": "G protein-coupled GABA receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) GABA receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38913", "l": "26-desgluco-avenacoside B + D-glucose => avenacoside B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110360", "l": "Recruitment of POLB to the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870289", "l": "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445064", "l": "Activation of Rac1 by VAV2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21817", "l": "a D-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13978", "l": "D-serine => NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222020", "l": "NUAK1 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55016", "l": "H(+) + menthone + NADPH + O2 = 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69142", "l": "Recruitment of Dna2 endonuclease (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23496", "l": "5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate", "d": [], "t": []}, {"i": "EC:2.8.3.14", "l": "\"5-hydroxypentanoate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15817", "l": "H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042018", "l": "interleukin-22 receptor activity", "d": ["Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42735", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951727", "l": "cAMP binds PKA tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27648", "l": "alpha-D-ribose 1-phosphate + hypoxanthine => inosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36456", "l": "ATP + H2O + L-alanylglycine(out) => ADP + H(+) + L-alanylglycine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470010", "l": "Dimerization of STATs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683735", "l": "CHEK2 is recruited to DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810376", "l": "ING2 binds PI5P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769383", "l": "CBY1 binds beta-catenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20004", "l": "glycolaldehyde + H2O + NAD(+) <=> glycolate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21226", "l": "CMP + H(+) + sphing-4-enine-phosphocholine => CDP-choline + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36834", "l": "2 caldariellaquinol + n H(+)(in) + O2 <=> 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69173", "l": "Joining of adjacent Okazaki fragments (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65150", "l": "H(+) + trilobatin + UDP => phloretin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15238", "l": "2 Fe(III)-[cytochrome c2] + NADPH => 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707594", "l": "Hemes bind LY96 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70899", "l": "histidine => urocanate + NH4+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944225", "l": "Association of procollagen type XVII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34831", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate = N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21025", "l": "CoA + glyoxylate + NADP(+) => H(+) + NADPH + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46876", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate = [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.33", "l": "\"mannuronan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19580", "l": "luteolin + UDP-alpha-D-glucose <=> H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70197", "l": "ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate => ATP + deamido-NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34838", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine <=> a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69334", "l": "2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19617", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46743", "l": "7-dehydrodesmosterol + H(+) + NADPH <=> desmosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25570", "l": "ADP + H(+) + nicotinate beta-D-ribonucleotide => ATP + beta-D-ribosylnicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34812", "l": "NADP(+) + tetrahydrocurcumin => dihydrocurcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004820", "l": "glycine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611147", "l": "Endocytic Uptake of HCMV Virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56988", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57351", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O <=> 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474210", "l": "Collagen type III degradation by MMP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38419", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24051", "l": "phosphate + sucrose <=> alpha-D-glucose 1-phosphate + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28138", "l": "H2O + streptothricin F = streptothricin F acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29198", "l": "(S)-dihydroorotate + a menaquinone <=> a menaquinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727303", "l": "mRNA9 is translated to protein 9b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42048", "l": "3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36713", "l": "ADP + CO2 + D-cycloserine + NH4(+) + phosphate => ATP + H(+) + H2O + O-ureido-D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655837", "l": "Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050151", "l": "oleate hydratase activity", "d": ["Catalysis of the reaction: (R)-10-hydroxystearate = H2O + oleate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30300", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 => a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3209165", "l": "ID1 sequesters ETS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806732", "l": "GNLY binds the bacterial cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015430", "l": "ABC-type glycerol-3-phosphate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53385", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43560", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20215", "l": "L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23860", "l": "acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.175", "l": "\"deacetylcephalosporin-C acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578712", "l": "Importin-8 binds AGO2:miRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0031127", "l": "alpha-(1,2)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050296", "l": "stipitatonate decarboxylase activity", "d": ["Catalysis of the reaction: H2O + stipitatonate = CO2 + H+ + stipitatate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13942", "l": "ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36317", "l": "CoA + hexadecan-1-ol + 2 NADP(+) => 2 H(+) + hexadecanoyl-CoA + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49337", "l": "2,2-dihydroxyspheroidene => H2O + spheroiden-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380949", "l": "AMPK is dephosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44201", "l": "12-methyloctadecanoate + ATP + CoA => 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63507", "l": "daunorubicin + H(+) + NADPH <=> 13-dihydrodaunorubicin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47496", "l": "lithocholate + NADP(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.392", "l": "\"3alpha-hydroxycholanate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141097", "l": "ligand-activated transcription activator activity", "d": ["A DNA-binding transcription activator activity regulated by binding to a ligand and that activates the transcription of specific genes and gene sets."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70798", "l": "H(+)(in) + L-lysine(out) <=> H(+)(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77294", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51028", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38411", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679266", "l": "Beclin-1 complex translocates to the ER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247836", "l": "Retromer recycles WLS to the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63502", "l": "NADP(+) + sulfinamide glutathione => H(+) + NADPH + S-nitrosoglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45247", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,4E)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981892", "l": "Active G alpha (z) binds RGS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679239", "l": "ULK complex translocates to the ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51995", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36464", "l": "glycyl-L-glutamate + H2O => glycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033505", "l": "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18336", "l": "ATP + oleandomycin <=> ADP + H(+) + oleandomycin 2'-O-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0016732", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen."], "t": []}, {"i": "EC:1.18.6.-", "l": "\"With dinitrogen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46506", "l": "AMP + dodecanoyl-[ACP] + H(+) => dodecanoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45999", "l": "a D-alpha-amino acid + a quinone + H2O <=> a 2-oxocarboxylate + a quinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36629", "l": "CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine => 2-hydroxytetracosanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389839", "l": "39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71705", "l": "taurocholate(in) => taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12044", "l": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20067", "l": "3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953037", "l": "E2F8 forms homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018471", "l": "4-chlorobenzaldehyde oxidase activity", "d": ["Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31645", "l": "H(+) + mycinamicin III + S-adenosyl-L-homocysteine => mycinamicin VI + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050150", "l": "o-pyrocatechuate decarboxylase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = catechol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75199", "l": "H2O + triuret = 1-carboxybiuret + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016719", "l": "9,9'-di-cis-zeta-carotene desaturase activity", "d": ["Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662620", "l": "MT3 binds cadmium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14109", "l": "L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44502", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32150", "l": "H2O + sepiapterin <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47085", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54824", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}, {"i": "EC:3.2.1.130", "l": "\"glycoprotein endo-alpha-1,2-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375131", "l": "Basigin binds CD98 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25888", "l": "dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate", "d": [], "t": []}, {"i": "EC:2.5.1.72", "l": "\"quinolinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55561", "l": "a hydroperoxyeicosatetraenoate => a hydroxy-epoxy-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004326", "l": "tetrahydrofolylpolyglutamate synthase activity", "d": ["Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0008940", "l": "nitrate reductase activity", "d": ["Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50171", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61300", "l": "5-deoxy-D-ribulose 1-phosphate = acetaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34755", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine = D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36934", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38401", "l": "(9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.25", "l": "\"phenylalanine/tyrosine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247960", "l": "Activation of p38 MAPK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031875", "l": "type 4 proteinase activated receptor binding", "d": ["Binding to a type 4 proteinase activated receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43108", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": [], "t": []}, {"i": "EC:1.7.2.4", "l": "\"nitrous-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944454", "l": "mTORC1 phosphorylates MAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18670", "l": "adenosine + H2O => adenine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018594", "l": "MECP2 binds LBR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.11", "l": "\"neprilysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54419", "l": "5alpha-campestan-3-one + NADP(+) <=> campest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76713", "l": "(15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22766", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168789", "l": "GHR internalization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12296", "l": "deacetylipecoside + H2O = dopamine + secologanin", "d": [], "t": []}, {"i": "EC:4.3.3.4", "l": "\"deacetylipecoside synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12608", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate <=> 1-deoxy-D-xylulose 5-phosphate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53826", "l": "7-oxotaurolithocholate + H(+) + NADH => NAD(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.300", "l": "\"pavine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.75", "l": "\"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17105", "l": "malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.197", "l": "\"malonyl-[acyl-carrier protein] O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36598", "l": "hydrogen sulfide + NADP(+) <=> NADPH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33325", "l": "a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036430", "l": "CMP kinase activity", "d": ["Catalysis of the reaction: ATP + CMP = ADP + CDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757686", "l": "SERPINA6 binds PREDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102812", "l": "4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine = cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76080", "l": "a dicarboxylate(in) + L-sepiapterin(out) => a dicarboxylate(out) + L-sepiapterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76081", "l": "a dicarboxylate(out) + L-sepiapterin(in) => a dicarboxylate(in) + L-sepiapterin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24764", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": [], "t": []}, {"i": "EC:5.1.3.23", "l": "\"UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102037", "l": "4-nitrotoluene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 = 4-nitrobenzyl alcohol + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20550", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43164", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": [], "t": []}, {"i": "EC:2.4.2.48", "l": "\"tRNA-guanine(15) transglycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54354", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733314", "l": "CSF1R trans-autophosphorylates on tyrosine-561 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50537", "l": "prostaglandin E2 => H2O + prostaglandin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.19", "l": "\"3-phenylpropanoate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19152", "l": "L-arginyl-[protein] + NAD(+) <=> H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41911", "l": "(3R)-hydroxyhexadecanoyl-[ACP] <=> (2E)-hexadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669023", "l": "TWEAK binds FN14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44395", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030273", "l": "melanin-concentrating hormone receptor activity", "d": ["Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65665", "l": "citrate(out) + 4 Na(+)(out) => citrate(in) + 4 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70461", "l": "a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046554", "l": "malate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41305", "l": "(4R)-hydroxysphinganine + dodecanoate => H2O + N-dodecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632677", "l": "PTCH is internalized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74121", "l": "delphinidin 3-O-beta-D-galactoside + H(+) + UDP => delphinidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20155", "l": "ADP + beta-L-arabinose 1-phosphate + H(+) => ATP + L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110219", "l": "Cleavage of thymine by TDG glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0046583", "l": "monoatomic cation efflux transmembrane transporter activity", "d": ["Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204949", "l": "NRIF and TRAF6 may activate JNK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5685230", "l": "CHEK1 phosphorylates RAD51 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60952", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine = (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.284", "l": "\"S-(hydroxymethyl)glutathione dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63401", "l": "Fe(II)-hydroxyheme i => Fe(II)-heme a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829047", "l": "F0 is palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28539", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70483", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941411", "l": "OSCN- reacts with Cys residues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018747", "l": "RHOQ GEFs activate RHOQ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209253", "l": "Autophosphorylated FU phosphorylates COS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22313", "l": "5-(methylsulfanyl)-D-ribose + ATP => ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19727", "l": "CO2 + UDP-beta-L-arabinopyranose => H(+) + UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37386", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66433", "l": "H(+)(out) + L-galactose(out) => H(+)(in) + L-galactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18950", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64280", "l": "(S)-1-phenylethylamine + pyruvate = acetophenone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30099", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685838", "l": "CX3 complex binds D-loop structures (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30429", "l": "(+)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47921", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O => ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199154", "l": "CD200 binds to CD200R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785711", "l": "Telomere shortening during replicative exhaustion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53917", "l": "an acyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51022", "l": "an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28178", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47127", "l": "glycine + hexacosanoate <=> H2O + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70126", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71117", "l": "3-hydroxyhispidin + H2O + NAD(+) => H(+) + hispidin + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879798", "l": "Expression of DEC1 (BHLHE40, BHLHB2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36502", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53201", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26476", "l": "alpha-D-galactose 1-phosphate + L-rhamnopyranose => beta-D-galactosyl-(1->4)-L-rhamnose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41516", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58055", "l": "(2-aminoethyl)phosphonate + acetyl-CoA <=> (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61689", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine => AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65296", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171106", "l": "LDLR:LDL complex => LDLR + LDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857565", "l": "Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015574", "l": "trehalose transmembrane transporter activity", "d": ["Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens."], "t": []}, {"i": "RHEA:17629", "l": "alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38933", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975188", "l": "TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851079", "l": "p-T,Y MAPK8,9 translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1591234", "l": "ZBP1 binds cytosolic DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018785", "l": "RHOBTB2 binds GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034073", "l": "tetrahymanol cyclase activity", "d": ["Catalysis of the reaction: squalene = tetrahymanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50016", "l": "H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13342", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35684", "l": "hexadecasphinganine + NADP(+) => 3-oxohexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160004", "l": "poly-ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon poly-ADP-ribosylation of the target protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54392", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784598", "l": "NPPA(124-151) binds NPR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19575", "l": "[phosphate](n+1) + ADP => [phosphate](n) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22707", "l": "2 H2O + ricinine <=> 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58091", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O <=> (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48939", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71746", "l": "2-oxoglutarate(out) + hexanedioate(in) <=> 2-oxoglutarate(in) + hexanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52587", "l": "chenodeoxycholoyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16438", "l": "glutathione + RX => a halide anion + an S-substituted glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23352", "l": "2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:2.6.1.19", "l": "\"4-aminobutyrate--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35098", "l": "choline <=> acetaldehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31748", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59499", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791363", "l": "TP53 stimulates ARID3A gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653936", "l": "Formation of Ragulator complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10427", "l": "H2O + N-benzoylglycine <=> benzoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16742", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40153", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+) => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33380", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O => (4R)-hydroxyeicosasphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102836", "l": "1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32755", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = apigenin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001729", "l": "ceramide kinase activity", "d": ["Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0032454", "l": "histone H3K9 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66912", "l": "avenanthramide C + S-adenosyl-L-methionine = avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048249", "l": "high-affinity phosphate transmembrane transporter activity", "d": ["Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64091", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA <=> 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72745", "l": "leukotriene C4(in) => leukotriene C4(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44038", "l": "12,13-dihydroxy-(9Z)-octadecenoate => 12,13-epoxy-(9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14398", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (4Z)-2-oxohept-4-enedioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19333", "l": "H(+) + oxalyl-CoA = CO2 + formyl-CoA", "d": [], "t": []}, {"i": "EC:4.1.1.8", "l": "\"oxalyl-CoA decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507868", "l": "Aquaporins passively transport water into cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786421", "l": "CHIA hydrolyses chitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30329", "l": "all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21363", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) <=> diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38926", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH <=> a ubiquinol + Na(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.108", "l": "\"HtrA2 peptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684096", "l": "CDK2 phosphorylates RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10976", "l": "H(+) + NADH + O2 + quinolin-2-ol = 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.16", "l": "\"2-hydroxyquinoline 5,6-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28535", "l": "dTTP + H2O => diphosphate + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168374", "l": "RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578712", "l": "Importin-8 binds AGO2:miRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14234", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72855", "l": "ADP(out) + dADP(in) = ADP(in) + dADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54085", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine => archaeosine(15) in tRNA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2574845", "l": "AJUBA binds centrosome-associated AURKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449855", "l": "IL10 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59780", "l": "L-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75992", "l": "a dicarboxylate(in) + N-benzoylglycine(out) => a dicarboxylate(out) + N-benzoylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43086", "l": "2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45407", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate <=> 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22390", "l": "CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine => acetyl-CoA + N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12990", "l": "a dolichyl beta-D-mannosyl phosphate + H2O => a dolichyl phosphate + D-mannose + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6802973", "l": "PLK3 phosphorylates CDC25C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797553", "l": "Protein 4.1 binds CASK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60428", "l": "(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.1.134", "l": "\"(indol-3-yl)acetyl-L-aspartate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42938", "l": "2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(32) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48326", "l": "a ganglioside Fuc-GD1b + GDP + H(+) => a ganglioside GD1b + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49242", "l": "L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11498", "l": "3-(uracil-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004795", "l": "threonine synthase activity", "d": ["Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222431", "l": "Peroxynitrite is reduced to nitrite by AhpC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20706", "l": "an N-acetyl-D-amino acid + CoA + H(+) => a D-alpha-amino acid + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73065", "l": "H(+)(in) + Mn(2+)(out) => H(+)(out) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43372", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22340", "l": "3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.97", "l": "\"3-hydroxybenzyl-alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52021", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => A + H2O + resolvin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44633", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9035227", "l": "TXN2 binds CysS248-MPST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033889", "l": "N-sulfoglucosamine-3-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497794", "l": "Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25565", "l": "H2O + N-acetyl-4-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20811", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-7-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56303", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050239", "l": "pyrithiamine deaminase activity", "d": ["Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53560", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27308", "l": "1-pyrroline-2-carboxylate + AH2 => A + D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047679", "l": "arginine racemase activity", "d": ["Catalysis of the reaction: L-arginine = D-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67020", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.57", "l": "\"methyltransferase cap1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66400", "l": "ATP + glutathione(in) + glycocholate(in) + H2O = ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28961", "l": "D-xylose(out) + H(+)(out) => D-xylose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051670", "l": "inulinase activity", "d": ["Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0044325", "l": "transmembrane transporter binding", "d": ["Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008397", "l": "sterol 12-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O."], "t": []}, {"i": "EC:1.14.14.139", "l": "\"5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701488", "l": "Active ALK phosphorylates JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70917", "l": "guanosine(out) + H(+)(out) => guanosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210439", "l": "glutamate uptake by astrocytes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49935", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,5Z)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49884", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54272", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59720", "l": "D-maltohexaono-1,5-lactone + H2O = D-maltohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46636", "l": "5beta-dihydrotestosterone + NADP(+) = H(+) + NADPH + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034905", "l": "5-chloro-4-hydroxy-2-oxopentanate aldolase activity", "d": ["Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13214", "l": "H2O + NADP(+) + succinate semialdehyde => 2 H(+) + NADPH + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28735", "l": "H(+)(in) + spermidine(out) = H(+)(out) + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15435", "l": "diphosphate + sophoraflavanone B => (2S)-naringenin + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18135", "l": "adenosine 5'-phosphosulfate + diphosphate => ATP + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67506", "l": "1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23286", "l": "dimethylallyl diphosphate => isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.110", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685319", "l": "CX3 complex formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65923", "l": "L-kynurenine + pyruvate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53457", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38051", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69706", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O <=> beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687107", "l": "MAPK4,6 translocate to nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40722", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0036137", "l": "kynurenine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848338", "l": "PNPLA4 hydrolyzes TAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621411", "l": "EGR2 and SREBF2(1-484) dimer bind HMGCR gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15074", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O => D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005008", "l": "hepatocyte growth factor receptor activity", "d": ["Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804741", "l": "MDM2 forms homo- or heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72459", "l": "fumarate(in) + L-aspartate(out) = fumarate(out) + L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42088", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377644", "l": "Release of CSK from SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60709", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58026", "l": "H(+) + oleanolate 3-O-beta-D-glucoside + UDP => oleanolate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272753", "l": "Interaction of DAP12 and KIR2DS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209141", "l": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627078", "l": "XIAP binds CASP9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67352", "l": "malonyl-CoA + rhaponticin = 6-O-malonyl-rhaponticin + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193774", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67441", "l": "H2O + N(alpha)-acetyl-L-methionine => acetate + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.3", "l": "\"cystinyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62146", "l": "2 dGDP => dGMP + dGTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29458", "l": "D-serine(in) <=> D-serine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59381", "l": "4-amino-4-deoxyprephenate + NAD(+) => 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60855", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295519", "l": "IL7R is phosphorylated on Y499 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444100", "l": "PROT mediates L-proline uptake (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437230", "l": "L1-FGFR cis-heterodimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65349", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA => 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33850", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160874", "l": "HYAL1 hydrolyses (HA)50 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50452", "l": "prostaglandin H3 = prostaglandin E3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49593", "l": "2-hydroxyisobutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008829", "l": "dCTP deaminase activity", "d": ["Catalysis of the reaction: dCTP + H2O = dUTP + NH3."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72388", "l": "2 hydrogencarbonate(out) + sulfate(in) => 2 hydrogencarbonate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73655", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": [], "t": []}, {"i": "EC:1.4.2.2", "l": "\"nicotine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71895", "l": "dGTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66110", "l": "(2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate => 2-oxobutanoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51604", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.25", "l": "\"p-cymene methyl-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49469", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50883", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol <=> 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674529", "l": "AAMP binds to TBXA2R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69782", "l": "2-oxindole-3-acetate + succinyl-CoA <=> (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33687", "l": "3'-N-debenzoyltaxol + benzoyl-CoA = CoA + H(+) + taxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51585", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50746", "l": "2 aminomethylphosphonate + 2 glyoxylate + 2 H(+) => 2 glyphosate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641147", "l": "DACT1 binds DVL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23732", "l": "(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.33", "l": "\"diphosphomevalonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70010", "l": "anthranilate + ATP + H(+) <=> 2-aminobenzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725206", "l": "IgE binds FCERI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003963", "l": "RNA-3'-phosphate cyclase activity", "d": ["Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63109", "l": "16-hydroxy-ilicicolin A epoxide => ascofuranol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "52.216565680193824", "identifiers": [{"i": "GO:0022834", "l": "ligand-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381337", "l": "Expression of CEBPB in adipogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793383", "l": "Expression of TBX6 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39899", "l": "7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.324", "l": "\"7-deoxyloganetin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.101", "l": "\"L-proline amide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382061", "l": "Extracellular processing of novel PDGFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74676", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918227", "l": "Recruitment of TRAF3 to MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42477", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20059", "l": "CO2 + NH4(+) + sarcosine => 2 H(+) + H2O + N-carbamoylsarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64225", "l": "AH2 + O2 + uridine(34) in tRNA => 5-hydroxyuridine(34) in tRNA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11434", "l": "7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445079", "l": "Phosphorylation of L1 by ERK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31402", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) <=> all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400204", "l": "PPARA binds RXRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70854", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35665", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48596", "l": "1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16854", "l": "N(6)-(1,2-dicarboxyethyl)-AMP => AMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947538", "l": "Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14497", "l": "A + pyridoxine = AH2 + isopyridoxal", "d": [], "t": []}, {"i": "EC:1.1.99.9", "l": "\"pyridoxine 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793666", "l": "MDM2 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797100", "l": "CCNK binds CDK13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419003", "l": "Interaction of Nectins with Afadin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.41", "l": "\"riboflavin reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981621", "l": "C3 convertases spontaneously dissociate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44287", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA <=> 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25284", "l": "(S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473596", "l": "Collagen type I degradation by MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106263", "l": "1-acylglycerophosphoserine O-acyltransferase activity", "d": ["Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA."], "t": []}, {"i": "RHEA:33191", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.n6", "l": "\"1-acylglycerophosphoserine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36282", "l": "H(+) + NADH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35083", "l": "diacetylchitobiose-6'-phosphate + H2O = acetate + N'-monoacetylchitobiose-6'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47742", "l": "CO2 + demethylphylloquinone + diphosphate => 1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23144", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) = 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.240", "l": "\"N-acetylhexosamine 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73121", "l": "H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64623", "l": "(E)-sinapyl alcohol + acetyl-CoA <=> (E)-sinapoyl actetate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443774", "l": "Trans-homodimerization of Neurofascin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11015", "l": "H2O + L-tryptophanamide <=> L-tryptophan + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807826", "l": "LDHAL6B reduces PYR to LACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093327", "l": "EPHA binds TIAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72180", "l": "Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714580", "l": "SLC6A3 binds DRIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53114", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74039", "l": "D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64578", "l": "2 Fe(II)-[cytochrome b5] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome b5] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707516", "l": "FeHM dissociates from MetHb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211874", "l": "CYP2S1 4-hydroxylates atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67856", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.23", "l": "\"nitroarene dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27862", "l": "3'-GMP + H2O = guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873794", "l": "PCTP binds PC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29713", "l": "cadaverine(out) + H(+)(out) => cadaverine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53588", "l": "NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72623", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base = a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10581", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.8", "l": "\"limonene dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n14", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39879", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75457", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69755", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 = (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30928", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O => 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734573", "l": "Expression of GATA6 in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.48", "l": "\"histone acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2219524", "l": "PDPK1 binds PIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66697", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22249", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) => 7,8-dihydroxykynurenate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49520", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.53", "l": "\"mRNA N(6)-methyladenine demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17685", "l": "H(+) + uracil 5-carboxylate = CO2 + uracil", "d": [], "t": []}, {"i": "EC:4.1.1.66", "l": "\"uracil-5-carboxylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26318", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74515", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47974", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139909", "l": "Translocation of BMF to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353314", "l": "XP-C-RAD23B heterodimer binds to damaged DNA site with lesion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10175", "l": "(3R)-hydroxybutanoate dimer + H2O <=> 2 (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63863", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31813", "l": "diphosphate + viridiflorene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709360", "l": "H2O2 reduces MetHb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709406", "l": "CO binds to Cytochrome c oxidase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430347", "l": "MigFilin associates with Filamin and F-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70420", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O => 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45858", "l": "4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43800", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22793", "l": "isonocardicin A => nocardicin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20434", "l": "NAD(+) + xylitol => D-xylulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74551", "l": "H2O + L-seryl-tRNA(Ser) = L-serine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051192", "l": "prosthetic group binding", "d": ["Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61136", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + quercetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51820", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) = AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.55", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018794", "l": "RHOV binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47627", "l": "cis-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939201", "l": "ESR dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683593", "l": "ATG7:ATG3:LC3 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950567", "l": "Expression of Plasminogen activator inhibitor 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199169", "l": "MHC Class I interacts with CD160 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41328", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69629", "l": "H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.21", "l": "\"Enterobacter ribonuclease\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614669", "l": "FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64100", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65474", "l": "CoA + ethyl 2-methylbutanoate => 2-methylbutanoyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901074", "l": "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41962", "l": "a ganglioside GA1 (d18:1(4E)) + H(+) + UDP => a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034862", "l": "Activated NTRK3 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218906", "l": "RIPK3 phosphorylates MLKL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784648", "l": "CREB3L3 (1-?) translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69153", "l": "spermine monoaldehyde => acrolein + spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.103", "l": "\"keratan-sulfate endo-1,4-beta-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829200", "l": "F0 is cleaved, releasing F1, F2, F(110-136) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53870", "l": "1-hydroxyphenazine + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692131", "l": "SOX9 binds the FGF9 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55015", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67259", "l": "H2O + NAD(+) + propanal <=> 2 H(+) + NADH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566979", "l": "Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72999", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] = L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}, {"i": "EC:3.4.11.17", "l": "\"tryptophanyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23753", "l": "all-trans-undecaprenol + ATP => ADP + all-trans-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19824", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60353", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 => CO + H(+) + N-octanoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008405", "l": "arachidonic acid 11,12-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid."], "t": []}, {"i": "RHEA:51480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56834", "l": "2,3,6-trichlorohydroquinone + 2 glutathione => 2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051380", "l": "norepinephrine binding", "d": ["Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14268", "l": "(S)-4-amino-5-oxopentanoate <=> 5-aminolevulinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51580", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) = a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683755", "l": "Spike protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44571", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) <=> 2-all-trans-hexaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25399", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": [], "t": []}, {"i": "EC:5.4.4.6", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8S-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35022", "l": "L-threonine(in) <=> L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350651", "l": "Caspase-mediated cleavage of MASK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65879", "l": "5alpha-androst-1-ene-3,17-dione + H2O <=> 1-hydroxy-5alpha-androstan-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197698", "l": "Src phosphorylate WASP,N-WASP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57280", "l": "a guanosine in RNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13742", "l": "3-phenylpyruvate + L-tryptophan => indole-3-pyruvate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55164", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 = H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050200", "l": "plasmalogen synthase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42739", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947499", "l": "Exchange of oxygen with sulfur in MoCo (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850997", "l": "TRIM27 binds PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72385", "l": "Na(+)(in) + urate(out) => Na(+)(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690701", "l": "SHP1 binds p-CD22 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31062", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) <=> 2 H(+) + imidazole-4-acetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202216", "l": "Phosphorylation of SLP-76 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74355", "l": "a cytidine in mRNA + H(+) + H2O = a uridine in mRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36680", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55204", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.32", "l": "\"7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13828", "l": "GDP-alpha-D-rhamnose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252001", "l": "ATP1B4 binds SNW1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727819", "l": "TAK1 phosphorylates MKK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683801", "l": "CHEK2 phosphorylates BRCA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43696", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}, {"i": "EC:2.7.4.27", "l": "\"([Pyruvate, phosphate dikinase] phosphate) phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013021", "l": "GDIs block activation of RHOB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004779", "l": "sulfate adenylyltransferase activity", "d": ["Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140789", "l": "histone phosphatase activity", "d": ["Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662466", "l": "XYLB phosphorylates D-xylulose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65357", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64668", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864577", "l": "TFAP2C translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10530", "l": "10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36673", "l": "CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine => (17Z)-hexacosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32219", "l": "all-trans-lycopene = gamma-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13432", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) <=> 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72540", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66549", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol => 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52790", "l": "Mg(2+) + pheophytin a => chlorophyll a + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693783", "l": "NAALADases hydrolyse NAAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678327", "l": "MIOX oxidises Ins to GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33757", "l": "(4R)-hydroxysphinganine + hexadecanoate => H2O + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821366", "l": "AKAP8L binds MLL2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22659", "l": "CDP-ethanolamine + L-serine <=> CMP + H(+) + L-serine-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15361", "l": "a dolichyl phosphate + UDP-alpha-D-xylose = a dolichyl D-xylosyl phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.32", "l": "\"dolichyl-phosphate D-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047428", "l": "arylacetonitrilase activity", "d": ["Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015232", "l": "heme transmembrane transporter activity", "d": ["Enables the transfer of heme from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66862", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate => dimethylallyl diphosphate + 4 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45327", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050206", "l": "oximinotransferase activity", "d": ["Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50620", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.343", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390329", "l": "Dephosphorylation of AKT by PP2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72020", "l": "2-oxoglutarate + H(+) + O2 + trihazone A => 2 CO2 + H2O + succinate + trihazone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981713", "l": "C4b binds to cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31473", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP => beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37594", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626549", "l": "IQGAPs bind CALM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30662", "l": "4-(phosphooxy)-L-threonine + H2O <=> 4-hydroxy-L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47404", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818937", "l": "MEN1 binds MLL1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73135", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59764", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24922", "l": "L-homoserine <=> 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63033", "l": "a fatty acylamide + H2O => a fatty acid + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34190", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004653", "l": "polypeptide N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51284", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391933", "l": "EP3 receptor can bind PGE2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29787", "l": "ATP + glutathione(in) + H2O = ADP + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56119", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28228", "l": "capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74619", "l": "CMP(in) + UMP(out) = CMP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75824", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15185", "l": "L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624798", "l": "LBR binds KPNB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018785", "l": "RHOBTB2 binds GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65839", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001604", "l": "urotensin II receptor activity", "d": ["Combining with urotensin II to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354087", "l": "Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61981", "l": "H(+) + NADPH + ubiquinone-10 => NADP(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24260", "l": "(3E)-2-oxohex-3-enedioate + H(+) = 2-oxopent-4-enoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.77", "l": "\"2-oxo-3-hexenedioate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047724", "l": "inosine nucleosidase activity", "d": ["Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58024", "l": "oleanolate + UDP-alpha-D-glucose = H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.368", "l": "\"oleanolate 3-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849878", "l": "PSD-95 binds NMDA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20710", "l": "ADP + D-erythritol 4-phosphate + H(+) => ATP + erythritol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678854", "l": "S1PR1 binds S1PR1 agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047308", "l": "alanine-oxomalonate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23407", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975040", "l": "KRAB-ZNF / KAP Interaction (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20675", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139895", "l": "tBID activates BAK protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805620", "l": "KAT6A and PML bind TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617661", "l": "MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10395", "l": "(E)-cinnamyl alcohol + NADP(+) <=> (E)-cinnamaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68356", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate = L-glutamate + N-acetyl-L-aspartate", "d": [], "t": []}, {"i": "EC:3.4.17.21", "l": "\"glutamate carboxypeptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41590", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191072", "l": "Synthesis of Cx43 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014449", "l": "RHOG binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43445", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP => 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850997", "l": "TRIM27 binds PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985943", "l": "p-Y701-STAT1 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629679", "l": "PDE3A inhibitors bind PDE3A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34600", "l": "15-methylhexadecasphinganine + NADP(+) => 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31972", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 => 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327746", "l": "FN1 aggregation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51814", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-921155", "l": "p-STAT5 dissociates from the receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43847", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 <=> (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029471", "l": "Hydrolysis of PC to PA by PLD (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32542", "l": "(2E)-geranyl diphosphate <=> (+)-car-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43185", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA => H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805638", "l": "KAT6A acetylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623643", "l": "RDH13 reduces atRAL to atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32132", "l": "(2S)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787591", "l": "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56586", "l": "propane-1,2-diol => 1,2-epoxypropane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25006", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482772", "l": "Release of platelet cytosolic components (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757686", "l": "SERPINA6 binds PREDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73943", "l": "dehydrogriseofulvin + H(+) + NADPH = griseofulvin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76275", "l": "Na(+)(out) + uracil(out) = Na(+)(in) + uracil(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.4", "l": "\"ABC-type Na(+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15164", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51337", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507873", "l": "Aquaporins passively transport urea out of cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392129", "l": "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209165", "l": "ID1 sequesters ETS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52915", "l": "3-dimethylallyl-4-hydroxymandelate + O2 <=> 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080014", "l": "thalianol hydroxylase activity", "d": ["Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080118", "l": "brassinosteroid sulfotransferase activity", "d": ["Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034827", "l": "1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-500708", "l": "GRIK3 homomer binds glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817435", "l": "DUX4 binds the KDM4E gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788975", "l": "Superoxide anion dismutates to H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25821", "l": "H2O + O2 + spermidine => 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35792", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine => H(+) + kanamycin X + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114352", "l": "Sequestration of tBID by BCL-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202394", "l": "Translocation of CARMA1 to Plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76831", "l": "H2O + hexylamine + NAD(+) = H(+) + hexanal + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044717", "l": "8-hydroxy-dADP phosphatase activity", "d": ["Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate."], "t": []}, {"i": "REACT:R-HSA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21248", "l": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15099", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12617", "l": "ATP + N-acetyl-alpha-D-galactosamine = ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.157", "l": "\"N-acetylgalactosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018767", "l": "2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15719", "l": "doxorubicin + H2O + NADP(+) => daunorubicin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615348", "l": "AGT(34-41) binds to AGTR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47867", "l": "1,2,3-trioctanoylglycerol + H2O <=> dioctanoylglycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26103", "l": "cis-homoaconitate + H2O => (2R)-homocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047102", "l": "aminomuconate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68033", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561072", "l": "OCT3 mediates renal uptake of organic cations (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53642", "l": "(-)-alpha-amorphene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69556", "l": "D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578777", "l": "DMPK phosphorylates PLN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25154", "l": "3-phenylpyruvate + L-glutamate => 2-oxoglutarate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50887", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O <=> (9Z-octadecenoyl)-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371582", "l": "HSBP1 binds HSF1 trimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30961", "l": "7,9,9'-tri-cis-neurosporene + a quinol => 9,9'-di-cis-zeta-carotene + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010329", "l": "auxin efflux transmembrane transporter activity", "d": ["Enables the transfer of auxin, from one side of a membrane to the other, out of a cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635854", "l": "GLI2,3 are degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39254", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209536", "l": "IkB is ubiquitinated and degraded (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.11", "l": "\"(3R)-3-[(carboxylmethyl)amino]fatty acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12486", "l": "a ribonucleoside + phosphate => a ribonucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18205", "l": "AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.14", "l": "\"progesterone 11alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690196", "l": "USP8 deubiquitinates RNF128 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876868", "l": "ECE1 cleaves EDN1(53-90) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620456", "l": "sGC stimulators bind sGC:NO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52612", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.99.41", "l": "\"3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40953", "l": "acetate + L-2,4-diaminobutanoate => (2S)-2-acetamido-4-aminobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70899", "l": "histidine => urocanate + NH4+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66546", "l": "H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210282", "l": "Interaction of GPVI and FceRI gamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33675", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) = H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33624", "l": "ATP + CoA + dodecanoate => AMP + diphosphate + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62176", "l": "GDP-alpha-D-glucose + H2O = alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11683", "l": "ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39991", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19599", "l": "L-citrulline + NH4(+) => H2O + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944223", "l": "Association of procollagen type V (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.25", "l": "\"branched-chain alpha-keto acid dehydrogenase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009488", "l": "IL34 binds CSF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21499", "l": "dimethylallyl diphosphate + H2O <=> diphosphate + prenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451366", "l": "Activation of p38MAPK by DSCAM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0106359", "l": "2-hydroxyacyl-CoA lyase activity", "d": ["Catalysis of the reaction: a 2-hydroxy fatty acyl-CoA = a fatty aldehyde + formyl-CoA. The reaction acts on 2-hydroxy-3-methyl-branched fatty acyl-CoA and 2-hydroxy-long-chain fatty acyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45188", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54819", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] <=> [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57682", "l": "a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645428", "l": "ALPK1 binds ADP-heptose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37707", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653957", "l": "Rag dimer formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45989", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 => 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19766", "l": "glycerol => 3-hydroxypropanal + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14632", "l": "ATP + N-acetyl-L-glutamate <=> ADP + N-acetyl-L-glutamyl 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23354", "l": "L-glutamate + succinate semialdehyde => 2-oxoglutarate + 4-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73861", "l": "1-methylnicotinamide(in) => 1-methylnicotinamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13574", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30174", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50073", "l": "ATP + H2O + tauroursodeoxycholate(in) => ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25830", "l": "A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.7", "l": "\"Glu-Glu dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176445", "l": "SMURF2 binds SMAD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160125", "l": "pH-gated sodium channel activity", "d": ["A gated channel activity that enables the transmembrane transfer of a sodium ion by a channel that opens in response to a change in pH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389350", "l": "Activation of Cdc42 by pVav1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69009", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 => 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390595", "l": "Calcium Binds Troponin-C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618107", "l": "ATP binding to HSP90 triggers conformation change (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265973", "l": "Monoubiquitination of FANCI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37751", "l": "2-methyl-trans-aconitate = 2-methyl-cis-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404142", "l": "atROL binds RBP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59958", "l": "a nitrile + sulfate + sulfur => a (Z)-N-(sulfonatooxy)alkanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68867", "l": "H2O + isomaltose <=> alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15961", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose = H(+) + taxiphyllin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.178", "l": "\"hydroxymandelonitrile glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23387", "l": "D-cellobiose <=> beta-D-glucosyl-(1->4)-D-mannopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654409", "l": "Activated FGFR3 binds FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482772", "l": "Release of platelet cytosolic components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12061", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0008121", "l": "ubiquinol-cytochrome-c reductase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55659", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid chi-end derivative + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682769", "l": "LGI2 binds ADAM22,23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58972", "l": "H2O + O2 + vanillin = H(+) + H2O2 + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12430", "l": "benzene-1,2,4-triol + NAD(+) => 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928625", "l": "PAKs autophosphorylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12939", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53665", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) => H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.217", "l": "\"protodeoxyviolaceinate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58154", "l": "2 H(+) + NADH + phosphonoacetate => H2O + NAD(+) + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047352", "l": "adenylylsulfate-ammonia adenylyltransferase activity", "d": ["Catalysis of the reaction: 5'-adenylyl sulfate + NH4 = adenosine 5'-phosphoramidate + 2 H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71589", "l": "(S)-malate(out) + 2-oxoglutarate(in) => (S)-malate(in) + 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102240", "l": "soyasapogenol B glucuronide galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate = H+ + UDP + soyasaponin III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32170", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0008865", "l": "fructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730872", "l": "Activation of Calcineurin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29261", "l": "(2R,3R)-tartrate(in) + succinate(out) => (2R,3R)-tartrate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69323", "l": "glucoerucin + H2O <=> (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928588", "l": "EPHBs binds PTK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19052", "l": "(5R)-5-hydroxy-L-lysine + GTP <=> (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31786", "l": "H2O + tuberculosinyl diphosphate <=> diphosphate + tuberculosinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015093", "l": "ferrous iron transmembrane transporter activity", "d": ["Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180632", "l": "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76531", "l": "H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2 = H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003846", "l": "2-acylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:1904091", "l": "non-ribosomal peptide synthetase activity", "d": ["Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13872", "l": "NAD(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38576", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53701", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18789", "l": "D-glucosamine 6-phosphate = D-galactosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.42", "l": "\"D-glucosamine-6-phosphate 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14590", "l": "luteolin + S-adenosyl-L-methionine => chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51661", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 => an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28384", "l": "D-glucose 6-phosphate + L-lysine => H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21118", "l": "beta-D-glucose 1-phosphate + D-glucose => D-maltose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694462", "l": "ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68920", "l": "ATP + H(+) + NADPH + pentanoate = AMP + diphosphate + NADP(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33997", "l": "5-oxo-L-proline + butirosin B => gamma-L-glutamyl-butirosin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52382", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853745", "l": "RET binds GFRA1,GFRA3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69526", "l": "D-glucose + H2O2 => D-sorbitol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.100", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9633044", "l": "ESR binds STRN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68837", "l": "(2Z,6E)-farnesyl diphosphate => (6R,7S)-himachala-9,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371422", "l": "ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16558", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) => 2-aminomuconate 6-semialdehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65585", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419389", "l": "LPA-binding receptors bind LPA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74062", "l": "beta-alanine(out) + L-alanine(in) <=> beta-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22840", "l": "D-glutamine + H2O = D-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.35", "l": "\"D-glutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110307", "l": "REV1 binds AP-dsDNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14291", "l": "AMP + diphosphate + omega-dicarboxyl-CoA => a dicarboxylate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14568", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109639", "l": "Formation of the closed pre-initiation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856189", "l": "TNFSF8 binds TNFRSF8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952128", "l": "RUNX3 binds TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43611", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O <=> 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086088", "l": "voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949276", "l": "RUNX3:CBFB binds the RORC gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390835", "l": "DRD1,5 bind DA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66404", "l": "ATP + glutathione(in) + H2O + taurocholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33435", "l": "fecosterol = episterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19909", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.2.3", "l": "\"L-lactate dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.6", "l": "\"exodeoxyribonuclease VII\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140822", "l": "NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44968", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH = NADP(+) + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72329", "l": "3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018576", "l": "catechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022942", "l": "GAD2 gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396009", "l": "STING binds c-di-GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395784", "l": "Nascent CMs transform into mature CMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21420", "l": "NADP(+) + prostaglandin I2 = 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.231", "l": "\"15-hydroxyprostaglandin-I dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9708275", "l": "PDE4A binds PDE4A inhibitors (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76441", "l": "19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin] => 19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051745", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity", "d": ["Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76281", "l": "hypoxanthine(in) + Na(+)(in) => hypoxanthine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140345", "l": "phosphatidylcholine flippase activity", "d": ["Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29749", "l": "3-phenylpropanoate(out) => 3-phenylpropanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64881", "l": "CDP + H2O => CMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71657", "l": "a thymidine in DNA + ADP-D-ribose => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36703", "l": "(2S,5S)-5-carboxymethylproline + ATP = (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.3.6", "l": "\"carbapenam-3-carboxylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36309", "l": "3,4-dihydroxybenzaldehyde + acetyl-CoA => (E)-caffeoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032093", "l": "SAM domain binding", "d": ["Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55927", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5444516", "l": "Formation of MSH2:MSH6 Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193641", "l": "IKK-beta is recruited (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64572", "l": "isopentenyl diphosphate + neryl diphosphate = (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389348", "l": "Activation of Rac1 by pVav1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24735", "l": "2-oxoglutarate + 4-hydroxybutanoate => (R)-2-hydroxyglutarate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357483", "l": "RAC1 binds PAK1-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19360", "l": "H(+) + L-proline betaine + NADPH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23770", "l": "an N-acylsphing-4-enine + CoA + H(+) => a fatty acyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46442", "l": "A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042008", "l": "interleukin-18 receptor activity", "d": ["Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823816", "l": "OPTN binds CASP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61637", "l": "ATP + CoA + isophthalate => AMP + diphosphate + isophthalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21662", "l": "benzoate + 2 H(+) + NADPH => benzaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63064", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + tetraacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24546", "l": "(S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) => H2O + L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72066", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) <=> glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156832", "l": "INF-gamma induced phosphorylation of L13a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64454", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59595", "l": "ATP + beta-alanine + L-arginine <=> ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50489", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617471", "l": "HOXA1 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.866383925293761", "identifiers": [{"i": "GO:0004601", "l": "peroxidase activity", "d": ["Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179413", "l": "Activated PKC-alpha  activate MMP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16662", "l": "fluoride + S-adenosyl-L-methionine => 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20286", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate => alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174445", "l": "RPA binds to the Flap on the C-strand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43304", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530445", "l": "CD59 inhibits MAC formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909724", "l": "Recruitment of IFNAR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67534", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66213", "l": "asc-omegaC5-CoA + O2 => asc-omegaDeltaC5-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13186", "l": "H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669906", "l": "Ligand-independent dimerization of KIT juxtamembrane domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683670", "l": "Protein E forms a homopentamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43854", "l": "3-oxo-dotriacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + triacontanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70348", "l": "bromide + L-tyrosine + NADP(+) => 3-bromo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16765", "l": "D-mannitol + NADP(+) = D-fructose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.138", "l": "\"mannitol 2-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32116", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 => CO2 + succinate + TRIBOA beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55995", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853405", "l": "TPX2 binds AURKA at centrosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671993", "l": "CIT-3 binds DLG4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20045", "l": "3-oxopropanoate + H2O + NAD(+) = 2 H(+) + malonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63391", "l": "2 A + Fe(II)-heme o + H2O <=> 2 AH2 + Fe(II)-heme a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218806", "l": "FYN autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50099", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371582", "l": "HSBP1 binds HSF1 trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76716", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione => (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696267", "l": "RND3 binds GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103059", "l": "UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose = H+ + kaempferol-3-rhamnoside + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64482", "l": "(1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52461", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58436", "l": "4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57339", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40257", "l": "(3R)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66863", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654422", "l": "Activated FGFR4 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033431", "l": "CGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67693", "l": "ATP + H2O + hexadecanedioate(in) => ADP + H(+) + hexadecanedioate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420883", "l": "Opsins act as GEFs for G alpha-t (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865711", "l": "RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070835", "l": "chromium ion transmembrane transporter activity", "d": ["Enables the transfer of chromium (Cr) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72915", "l": "D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28767", "l": "ethylnitronate + O2 = acetaldehyde + chemical entity + H(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.13.12.16", "l": "\"nitronate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047824", "l": "D-iditol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58919", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene <=> (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71671", "l": "glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22147", "l": "cis-aconitate + H2O <=> D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418553", "l": "cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2404142", "l": "atROL binds RBP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75739", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH = 10-oxooctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16211", "l": "cob(II)yrinate => Co-precorrin-8X", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052846", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity", "d": ["Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674385", "l": "p-T,Y MAPKs dimerize (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54846", "l": "ethyl butanoate + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68585", "l": "ATP + H2O + L-tryptophan(out) => ADP + H(+) + L-tryptophan(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42770", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2S)-2-hydroxycarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18132", "l": "2-oxoaldehyde + H2O + NADP(+) <=> a 2-oxocarboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72643", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213406", "l": "Disassociation of PLC-gamma1 from LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900756", "l": "NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42752", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.177", "l": "\"23S rRNA (pseudouridine(1915)-N(3))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38628", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23738", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => 5-hydroxyisourate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75366", "l": "thymidine(in) <=> thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13908", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60136", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43394", "l": "1D-myo-inositol 1,3-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50426", "l": "prostaglandin G1 => (8Z,11Z,14Z)-eicosatrienoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42066", "l": "2',3'-cGAMP + 2 diphosphate => ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55607", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.106", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28928", "l": "3,4,5-trihydroxybenzoate + O2 => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004176", "l": "ATP-dependent peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis."], "t": []}, {"i": "REACT:R-HSA-9698929", "l": "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53404", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2186780", "l": "Degradation of Ub-SMAD7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41833", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH => hexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65355", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839734", "l": "AXIN mutants destabilize the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39835", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44281", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507868", "l": "Aquaporins passively transport water into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73451", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) = adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46280", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.18", "l": "\"sphingolipid 8-(E)-desaturase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67325", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine => (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48884", "l": "NADP(+) + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47164", "l": "4alpha-carboxyzymosterol + NAD(+) = CO2 + NADH + zymosterone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20149", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.55", "l": "\"quinine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374896", "l": "Uptake of Noradrenaline (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36604", "l": "2-oxoglutarate + L-enduracididine + O2 => (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10114", "l": "H2O + L,L-cystathionine => L-homocysteine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28411", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725855", "l": "NR3C2 binds NR3C2 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33078", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine <=> 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49264", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O = (E)-caffeate + H(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44345", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide A + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18304", "l": "ATP + NH4(+) + XMP <=> AMP + diphosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49448", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O = alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": [], "t": []}, {"i": "EC:3.2.1.197", "l": "\"beta-1,2-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74481", "l": "(Z)-dehydrocyclopeptine + CO2 + H2O + succinate => (-)-cyclopeptine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23363", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21145", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60267", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62241", "l": "a thymidine(6-4)cytidine in DNA => a thymine-cytidine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59844", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH = (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852010", "l": "BTNL2 binds activated T cells surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375302", "l": "Kinetochore capture of astral microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76850", "l": "(R)-sec-butylamine + H2O + NAD(+) <=> butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69794", "l": "D-phenylalanyl-tRNA(Phe) + H2O <=> D-phenylalanine + H(+) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54406", "l": "2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854052", "l": "Formation of the SCF-FBXL7 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62787", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> bifonsecin B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71116", "l": "H(+) + hispidin + NADH + O2 => 3-hydroxyhispidin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75901", "l": "1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626817", "l": "PKC phosphorylates NCF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73559", "l": "dGTP(out) + UTP(in) = dGTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750942", "l": "USP14 deubiquitinates NLRC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102069", "l": "zerumbone synthase activity", "d": ["Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD = zerumbone + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672969", "l": "Phosphorylation of RAF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59336", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A = AH2 + demethylspheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50114", "l": "CoA + H(+) + N-octadecanoyl-taurine => octadecanoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54399", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202164", "l": "Translocation of PDK1 to Plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707659", "l": "Hemes:LY96 activates TLR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62870", "l": "H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+) => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031885", "l": "type 1 member 2 taste receptor binding", "d": ["Binding to a type 1 member 2 taste receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57204", "l": "glyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166869", "l": "TRAF6 binds MEKK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13882", "l": "a quinone + an aldehyde + H2O => a carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73341", "l": "beta-alanyl-5'-AMP + diphosphate => ATP + beta-alanine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19982", "l": "NADP(+) + S-(hydroxymethyl)glutathione => H(+) + NADPH + S-formylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667456", "l": "AVPR1A,B bind desmopressin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22258", "l": "a 3-oxoacyl-CoA + H(+) + NADPH => a (3R)-3-hydroxyacyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51855", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71475", "l": "H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19105", "l": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.19", "l": "\"aminobutyraldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38346", "l": "(20S)-ginsenoside Rd + H2O <=> (20S)-ginsenoside Rg3 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603548", "l": "NTRK3(496-641) binds NELFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114254", "l": "CYCS binds to APAF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016768", "l": "spermine synthase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015415", "l": "ATPase-coupled phosphate ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28123", "l": "ATP + di-trans,octa-cis-undecaprenol => ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44408", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33224", "l": "2-oxobutanoate + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3204303", "l": "MRE11 binds cytosolic DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67683", "l": "a long-chain fatty acyl-CoA + H2O <=> a long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66890", "l": "8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72531", "l": "ATP + H2O + methyl beta-D-galactoside(out) = ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420977", "l": "Ca permeable AMPA receptor ligand binding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658438", "l": "SPRED dimer binds NF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706364", "l": "Internalization of ubiquitinated FLT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72621", "l": "Ribosomal scanning  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875817", "l": "MET phosphorylates STAT3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73725", "l": "(2R,3S,11S)-aszonalenin + diphosphate => (S)-benzodiazepinedione + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46086", "l": "glycerol + phosphate => H2O + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0042879", "l": "aldonate transmembrane transporter activity", "d": ["Enables the transfer of aldonate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64968", "l": "dUTP + H2O = dUDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43546", "l": "ADP + gamma-L-glutamyltyramine + H(+) + phosphate => ATP + L-glutamate + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.5", "l": "\"hydroxymethylglutaryl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.67", "l": "\"thiopurine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17988", "l": "4-(trimethylamino)butanal + H2O + NAD(+) <=> 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48392", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685219", "l": "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51949", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626356", "l": "Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77077", "l": "Capping complex formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070917", "l": "inositol phosphoceramide synthase regulator activity", "d": ["Binds to and modulates the activity of inositol phosphoceramide synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47671", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37766", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18808", "l": "[DsbA protein]-disulfide + [protein]-dithiol <=> [DsbA protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647660", "l": "GSDME (1-270) binds PIPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835121", "l": "Heparin binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110322", "l": "Formation of Pol zeta complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55566", "l": "4-hydoxytryptamine 4-phosphate + ADP + H(+) => 4-hydroxytryptamine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36153", "l": "(E)-cinnamyl acetate + CoA => (E)-cinnamyl alcohol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199518", "l": "C3d-complexed antigen binds to complement receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20768", "l": "3-phosphonopyruvate + H(+) = CO2 + phosphonoacetaldehyde", "d": [], "t": []}, {"i": "EC:4.1.1.82", "l": "\"phosphonopyruvate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55583", "l": "ATP + H2O + L-glutamine <=> AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22225", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA => 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48242", "l": "a ganglioside GT1b + CMP + H(+) => a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022880", "l": "protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74003", "l": "A + peniprequinolone = AH2 + yaequinolone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31689", "l": "(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48605", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30514", "l": "2-demethylmenaquinone-8 + H(+) + NADPH <=> 2-demethylmenaquinol-8 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76070", "l": "an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine <=> an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730856", "l": "Autophosphorylation of PAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45462", "l": "a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656244", "l": "DRD2 binds DA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388468", "l": "AVP(20-28) binds AVPR1A,B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72370", "l": "estrone 3-sulfate(out) + succinate(in) <=> estrone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428917", "l": "G13 activation by TP receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251942", "l": "Hikeshi binds HSP70s:ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21298", "l": "D-galactono-1,4-lactone + H(+) + NADH => D-galactose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912412", "l": "NOTCH1 mRNA translation controlled by miRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043924", "l": "suramin binding", "d": ["Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802910", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173680", "l": "Activation of C5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72672", "l": "The 60S subunit joins the translation initiation complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60769", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 => 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76635", "l": "n H(+)(out) + Mn(2+)(in) = n H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16890", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate => 6-acetamido-3-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483219", "l": "PC is exchanged with PI by PITPNB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51418", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3R)-flavan-3-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28738", "l": "H(+)(in) + spermidine(out) <=> H(+)(out) + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32947", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14465", "l": "H2O + L-histidinol phosphate = L-histidinol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.15", "l": "\"histidinol-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186819", "l": "SH2 domain of Src binds to the active receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5604929", "l": "Activated protein C binds Protein S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9837337", "l": "DCAKD phosphorylates DP-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77616", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol => 1-decanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023027", "l": "MHC class I protein binding, via antigen binding groove", "d": ["Binding to a major histocompatibility complex class I molecules via the antigen binding groove."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-383190", "l": "HCO3- transport through ion channel (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57889", "l": "a quinone + 5 H(+)(in) + NADH => a quinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14112", "l": "L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68446", "l": "(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal => 5-cis-lycopene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75174", "l": "GTP + NAD(+) <=> GDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481007", "l": "Exocytosis of platelet alpha granule contents (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120301", "l": "histone lactyltransferase activity", "d": ["Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62356", "l": "8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174070", "l": "Association of Cdh1 with the APC/C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71656", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O => a thymidine in DNA + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677051", "l": "Formation of the PCAF-ATAC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166387", "l": "The FA anion diffuses away laterally from UCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062202", "l": "Labd-13(16),14-diene-9-ol synthase activity", "d": ["Catalysis of the reaction: peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol."], "t": []}, {"i": "RHEA:62184", "l": "peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031531", "l": "thyrotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52135", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O <=> a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757256", "l": "MCM3 binds MCM5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35030", "l": "ATP + H2O + tungstate(in) <=> ADP + H(+) + phosphate + tungstate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.26", "l": "\"intermediate cleaving peptidase 55\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62729", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) => (+)-malbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665767", "l": "Activated FMNL3 binds G-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57158", "l": "4-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72722", "l": "eIF2 activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851072", "l": "DNMT1-dependent PTPN6 gene silencing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694280", "l": "mRNA4 is translated to protein E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114684", "l": "Phosphorylation of Syntaxin-4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50666", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31041", "l": "(2E)-dodecenoyl-CoA + FADH2 => dodecanoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70740", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72743", "l": "leukotriene C4(out) = leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76692", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805109", "l": "CDK2 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656893", "l": "OPN1MW binds 11cRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427337", "l": "MBD2 binds methylcytosine in chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71717", "l": "H(+)(in) + L-leucyl-L-leucine(in) => H(+)(out) + L-leucyl-L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34058", "l": "festuclavine + NAD(+) <=> 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68748", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836606", "l": "SPHK1 binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102048", "l": "indole-3-acetyl-isoleucine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) = H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52355", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205231", "l": "Dimerization of KIT upon SCF binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53320", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.349", "l": "\"mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38385", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34404", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 => (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70588", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.55", "l": "\"non-reducing end alpha-L-arabinofuranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322422", "l": "Beta-catenin recruits SMARCA4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17335", "l": "acetate + H(+) + L-lupinate => O-acetyl-L-serine + zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950504", "l": "IL27 binds CRLF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41645", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39716", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047537", "l": "2-aminohexanoate transaminase activity", "d": ["Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41265", "l": "15-oxo-prostaglandin A1 + H(+) + NADH => NAD(+) + prostaglandin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432129", "l": "FGR binds and phosphorylates LRP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37622", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28180", "l": "colnelenate + H2O => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724099", "l": "ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29975", "l": "2'-deoxycytidine(in) + H(+)(in) = 2'-deoxycytidine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16969", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}, {"i": "EC:5.1.3.13", "l": "\"dTDP-4-dehydrorhamnose 3,5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56025", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27795", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030413", "l": "competence pheromone activity", "d": ["A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57678", "l": "4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167415", "l": "G-protein alpha subunit is inactivated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21831", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60213", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37168", "l": "(2E,6E)-farnesol + NAD(+) => (2E,6E)-farnesal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210273", "l": "Interaction of DAP12 and NKp44 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22996", "l": "H2O2 + L-ascorbate = 2 H2O + L-dehydroascorbate", "d": [], "t": []}, {"i": "EC:1.11.1.11", "l": "\"L-ascorbate peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74951", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 = (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60720", "l": "(E)-hept-2-enal + H2O + NADP(+) = (E)-hept-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25607", "l": "2-(3-methylsulfanyl)propylmalate + CoA + H(+) => 2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004590", "l": "orotidine-5'-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198314", "l": "DAG stimulates protein kinase C-delta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53807", "l": "allodeoxycholoyl-CoA + ursodeoxycholate <=> allodeoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25646", "l": "(2R,5R)-isomenthone + NADP(+) => (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905577", "l": "ganglioside GP1c binding", "d": ["Binding to ganglioside GP1c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23355", "l": "2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22656", "l": "CDP-ethanolamine + L-serine = CMP + H(+) + L-serine-phosphoethanolamine", "d": [], "t": []}, {"i": "EC:2.7.8.4", "l": "\"serine-phosphoethanolamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015410", "l": "ABC-type manganese transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72691", "l": "Formation of the 43S pre-initiation complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14783", "l": "6-carboxyhexanoyl-CoA + AMP + diphosphate => ATP + CoA + heptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66649", "l": "(2E,6E)-farnesyl diphosphate => african-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19671", "l": "GDP + H(+) + phosphate => GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168849", "l": "tBID binds to inactive BAX protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22532", "l": "(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170846", "l": "TGFBR2 recruits TGFBR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981931", "l": "RAC1 and CDC42 activate PAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11838", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35510", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68538", "l": "(-)-alpha-cedrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40958", "l": "(R)-5-phosphomevalonate + ATP <=> ADP + CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38948", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66366", "l": "6-methyl-3,7-dioxodecanedioyl-CoA => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30338", "l": "CTP + H(+) + H2O <=> NH4(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21495", "l": "2,3-dihydroxybenzoate + H(+) <=> catechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17573", "l": "demethylmacrocin + S-adenosyl-L-methionine = H(+) + macrocin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.102", "l": "\"demethylmacrocin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36922", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28410", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035885", "l": "exochitinase activity", "d": ["Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27537", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857686", "l": "FITM1, FITM2 bind TAGs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0030228", "l": "lipoprotein particle receptor activity", "d": ["Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11818", "l": "beta-D-fructose 6-phosphate => alpha-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71558", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) <=> 5-aminoethyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9652264", "l": "ERBB2 binds TKIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73339", "l": "ATP + beta-alanine + H(+) = beta-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13813", "l": "benzene + H(+) + NADH + O2 = cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.3", "l": "\"benzene 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033718", "l": "pyranose dehydrogenase (acceptor) activity", "d": ["Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48572", "l": "3,5-dichlorocatechol + O2 = (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71754", "l": "2-oxoglutarate(out) + glutarate(in) <=> 2-oxoglutarate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62633", "l": "a hydroperoxide + 2 glutathione => an alcohol + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835454", "l": "DNAJC3 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45155", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA <=> 3-oxopropanoyl-CoA + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983147", "l": "Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22229", "l": "H(+) + NADH + presqualene diphosphate => diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471621", "l": "Endostatin degradation by cathepsins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035950", "l": "Defective B4GALT1 does not transfer Gal to a branch of keratan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36705", "l": "(3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+) => (2S,5S)-5-carboxymethylproline + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351901", "l": "Caspase-mediated cleavage of MST3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14780", "l": "AMP + H(+) + H2O <=> IMP + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55720", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43788", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.193", "l": "\"tRNA(Met) cytidine acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56903", "l": "a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51884", "l": "L-proline betaine = D-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58504", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34052", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O => 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981606", "l": "Myoglobin binds oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43235", "l": "H2O + isatin <=> H(+) + isatinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n4", "l": "\"(-)-trans-carveol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74370", "l": "substance P(out) <=> substance P(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77068", "l": "Activation of GT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9833777", "l": "PKR binds activating host RNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902052", "l": "(25S)-Delta(7)-dafachronate binding", "d": ["Binding to (25S)-Delta(7)-dafachronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047660", "l": "amidinoaspartase activity", "d": ["Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2130706", "l": "MHC class II antigen processing (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28991", "l": "N-acetylneuraminate(in) = N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047144", "l": "2-acylglycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31763", "l": "a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": [], "t": []}, {"i": "EC:2.6.1.88", "l": "\"methionine transaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14422", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide => 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42890", "l": "(R)-3,5-bisphosphomevalonate + ADP + H(+) => (R)-3-phosphomevalonate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51089", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854209", "l": "TBC1D10A binds JFC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28864", "l": "H(+)(out) + lactose(in) => H(+)(in) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004073", "l": "aspartate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP+ + phosphate = 4-phospho-L-aspartate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629365", "l": "NEIL3 recognizes and binds to spiroiminodihydantoin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33558", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O <=> (4R)-hydroxysphinganine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70445", "l": "a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031767", "l": "gastric inhibitory polypeptide receptor binding", "d": ["Binding to a gastric inhibitory polypeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69083", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) <=> 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805507", "l": "APAF1 binds AVEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40391", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA = 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015504", "l": "cytosine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33490", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA <=> CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50475", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38054", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA <=> 1-butanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43302", "l": "a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer + H(+) + UDP => a neolactoside IV(3)-alpha-NeuGc-nLc4Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69670", "l": "H2O + luteolin 4'-O-beta-D-glucoside <=> beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11198", "l": "alpha-ribazole 5'-phosphate + H(+) + nicotinate => 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54427", "l": "L-aspartyl-[protein] + NAD(+) <=> 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29785", "l": "ADP + H(+) + L-cysteine(out) + phosphate => ATP + H2O + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72185", "l": "mRNA polyadenylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34018", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 <=> ergosterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58745", "l": "H2O + N(7)-methyl-GTP => diphosphate + H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26303", "l": "(S)-allantoin + CO2 => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704248", "l": "CHRM4 binds CHRM4 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853762", "l": "RET dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21469", "l": "dTDP-alpha-D-mycaminose + tylactone => 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57884", "l": "diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate", "d": [], "t": []}, {"i": "EC:7.2.3.1", "l": "\"Na(+)-exporting diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22626", "l": "acetaldehyde + pyruvate => (S)-4-hydroxy-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033803", "l": "kaempferol 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H+ + kaempferide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904931", "l": "MCM complex binding", "d": ["Binding to an MCM complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867344", "l": "OMA1 hydrolyses OPA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71952", "l": "3 Na(+)(out) + sulfate(out) => 3 Na(+)(in) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352059", "l": "SLC6A15-mediated amino acid uptake (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47119", "l": "eicosanoate + glycine <=> H2O + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389849", "l": "28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0106345", "l": "glyoxylate reductase activity", "d": ["Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433606", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65587", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018631", "l": "phenylacetate hydroxylase activity", "d": ["Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047695", "l": "benzoin aldolase activity", "d": ["Catalysis of the reaction: benzoin = 2 benzaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928576", "l": "RHOA:GTP binds ROCK, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199579", "l": "KIR2DL4 interacting with HLA-G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25793", "l": "ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12248", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}, {"i": "EC:1.3.1.98", "l": "\"UDP-N-acetylmuramate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47968", "l": "a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007882", "l": "IL1F10 is cleaved (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75884", "l": "NAD(+) => ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75691", "l": "2'-deoxyadenosine(in) = 2'-deoxyadenosine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73553", "l": "GDP(in) + UTP(out) => GDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74168", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] => formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.726079367374183", "identifiers": [{"i": "GO:0033764", "l": "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative."], "t": []}, {"i": "REACT:R-HSA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72335", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate = 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50714", "l": "7-chlorotetracycline + FAD + H(+) + 2 H2O => chloride + FADH2 + O2 + tetracycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53860", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) = dehydrocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209921", "l": "Monoiodinated tyrosine can be deiodinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66916", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017176", "l": "phosphatidylinositol N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28681", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-8 => 3-demethylubiquinol-8 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56850", "l": "H(+) + reumycin + S-adenosyl-L-homocysteine => 1,6-didemethyltoxoflavin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20906", "l": "(S)-1,2-epoxypropane + coenzyme M => (S)-2-hydroxypropyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53618", "l": "(+)-isoafricanol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065233", "l": "CS is cleaved from its proteoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.47", "l": "\"HIV-2 retropepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204485", "l": "Basigin binds CyPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388596", "l": "Melanocortin receptors bind melanocortins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21639", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58198", "l": "acetate + L-lysyl-[histone] => H2O + N(6)-acetyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17037", "l": "indole-3-ethanol + NADP(+) = H(+) + indole-3-acetaldehyde + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.191", "l": "\"indole-3-acetaldehyde reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198756", "l": "ERK1/2 phosphorylates MSK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49864", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18201", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": [], "t": []}, {"i": "EC:1.14.16.2", "l": "\"tyrosine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31108", "l": "3-phenylpyruvate + O2 => (2-hydroxyphenyl)acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849906", "l": "SALM1 binds NMDA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.39", "l": "\"chymase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202307", "l": "Change of PKC theta conformation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68318", "l": "1D-myo-inositol 2,4,5-triphosphate + phosphate => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031249", "l": "denatured protein binding", "d": ["Binding to a denatured protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938853", "l": "CDK6 binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66013", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22813", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methenyltetrahydrofolate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050262", "l": "ribosylnicotinamide kinase activity", "d": ["Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38515", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497863", "l": "The BH3 radical can decay to dihydrobiopterin (BH2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54526", "l": "3-hydroxyhexane-2,5-dione + CO2 => acetoacetate + H(+) + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52821", "l": "L-serine + succinyl-CoA => CoA + O-succinyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604308", "l": "NICD4 traffics to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22887", "l": "glyoxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39905", "l": "3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17154", "l": "CDP-D-glucose => CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592278", "l": "Autocatalytic activation of proMMP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40086", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010488", "l": "UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028525", "l": "NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005483", "l": "soluble NSF attachment protein activity", "d": ["Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69916", "l": "guanosine(out) + 2 Na(+)(out) => guanosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21877", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) => (S)-usnate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40336", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56697", "l": "D-ribulose 5-phosphate + L-tryptophan => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18885", "l": "GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.271", "l": "\"GDP-L-fucose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75891", "l": "Abortive Initiation After Second Transition (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27850", "l": "glycine + phenylacetyl-CoA = CoA + H(+) + phenylacetylglycine", "d": [], "t": []}, {"i": "EC:2.3.1.192", "l": "\"glycine N-phenylacetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015668", "l": "type III site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0004993", "l": "G protein-coupled serotonin receptor activity", "d": ["Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22730", "l": "L-selenocysteinyl-tRNA(Sec) + phosphate => H(+) + L-seryl-tRNA(Sec) + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004925", "l": "prolactin receptor activity", "d": ["Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66285", "l": "tomatidine + UDP-alpha-D-glucose => H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57038", "l": "(1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33564", "l": "(4R)-hydroxysphinganine + ATP => (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9035227", "l": "TXN2 binds CysS248-MPST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54902", "l": "hexadecanoyl-[ACP] + NAD(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418200", "l": "SRC-1 bound to ARRB2 is not activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35768", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine => 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784959", "l": "BPHL hydrolyses VACV to ACV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60665", "l": "H2O + NADPH => NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20948", "l": "3-sulfopyruvate + H(+) = CO2 + sulfoacetaldehyde", "d": [], "t": []}, {"i": "EC:4.1.1.79", "l": "\"sulfopyruvate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11263", "l": "H(+) + NADPH + O2 <=> H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462005", "l": "pro-defensin alpha 5 is secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-500708", "l": "GRIK3 homomer binds glutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042300", "l": "beta-amyrin synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64160", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide = ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": [], "t": []}, {"i": "EC:6.2.2.1", "l": "\"thioglycine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50995", "l": "thromboxane B2(out) <=> thromboxane B2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70585", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879674", "l": "CD97 binds CD55 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28393", "l": "N(6)-(D-psicosyl)-L-lysine <=> N(6)-(D-fructosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062059", "l": "FACT complex binding", "d": ["Binding to a FACT complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54353", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0034979", "l": "NAD-dependent protein deacetylase activity", "d": ["Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166817", "l": "Cleavage of C3 by C3 convertases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350769", "l": "trans-Golgi Network Coat Activation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015383", "l": "sulfate:bicarbonate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48941", "l": "an L-aminoacyl-L-amino acid + H2O => 2 an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34262", "l": "(+)-larreatricin + AH2 + O2 <=> (+)-3'-hydroxylarreatricin + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196017", "l": "Dynamin is recruited to the gap junction plaque (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681382", "l": "KIT mutants bind ripretinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63936", "l": "3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005024", "l": "transforming growth factor beta receptor activity", "d": ["Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35801", "l": "7,8-dihydroneopterin 3'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12879", "l": "acetate + H(+) + methylglyoxal => acetylacetone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.148", "l": "\"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509831", "l": "ITPA hydrolyses XTP to XMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70649", "l": "D-serine(in) + H(+)(in) => D-serine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74807", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16297", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.210", "l": "\"3beta-(or 20alpha)-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61774", "l": "H(+) + rebaudioside D + UDP => rebaudioside E + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72519", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate = 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047974", "l": "guanosine deaminase activity", "d": ["Catalysis of the reaction: guanosine + H2O = xanthosine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807872", "l": "Active ARF recruits coatomer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40171", "l": "dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610720", "l": "PKA phosphorylates GLI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170674", "l": "Dissociation of the Gi alpha:G olf complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620456", "l": "sGC stimulators bind sGC:NO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31304", "l": "a reduced flavin + NAD(+) => an oxidized flavin + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22740", "l": "ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43600", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH = 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33312", "l": "2 A + hydroxylamine + NH4(+) => 2 AH2 + H(+) + H2O + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20571", "l": "L-ornithine + urea => H2O + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34195", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 = 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156910", "l": "Formation of eEF1B complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836500", "l": "IKK complex is activated by PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797961", "l": "CHDH oxidises Cho to BETALD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30867", "l": "H2O + indole-3-acetaldehyde + NAD(+) = (indol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683593", "l": "ATG7:ATG3:LC3 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64220", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68237", "l": "L-glutamine(in) + Na(+)(in) => L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22907", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30125", "l": "H(+) + holo-[ACP] + tetradecanoate => H2O + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102216", "l": "maltodextrin water dikinase", "d": ["Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49445", "l": "(2-aminobenzoyl)acetyl-CoA + H2O => (2-aminobenzoyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429036", "l": "SLC2A9 transports Fru, Glc, urate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72773", "l": "7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990970", "l": "trans-activation response element binding", "d": ["Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24543", "l": "A + D-glucose <=> AH2 + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13313", "l": "H2O + O2 + sarcosine = formaldehyde + glycine + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.1", "l": "\"sarcosine oxidasee (formaldehyde-forming)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791169", "l": "Expression of WFS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21887", "l": "H2O + trithionate <=> H(+) + sulfate + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9833635", "l": "p-PKR dimer localizes to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54709", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55594", "l": "(3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP] => 2 (3R)-hydroxydecanoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983153", "l": "E1 mediated ubiquitin activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726580", "l": "PGR binds PGR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18801", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.20", "l": "\"rubber cis-polyprenylcistransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76847", "l": "(R)-sec-butylamine + H2O + NAD(+) = butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047135", "l": "bis-gamma-glutamylcystine reductase activity", "d": ["Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP+ = bis-gamma-glutamylcystine + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706837", "l": "AR binds AR antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209823", "l": "Tyrosine is hydroxylated to dopa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68321", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O => 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62844", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11659", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline <=> AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050598", "l": "taxane 13-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5alpha,13alpha-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59236", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + isoelisabethatriene", "d": [], "t": []}, {"i": "EC:4.2.3.203", "l": "\"isoelisabethatriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51245", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61541", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212642", "l": "L-Glutamine transport into neurons (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374673", "l": "L1 binds RanBPM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45099", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47590", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP + H(+) => a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48568", "l": "3-chlorocatechol + O2 = (2E,4Z)-2-chloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18154", "l": "2 GTP + H(+) => diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034074", "l": "marneral synthase activity", "d": ["Catalysis of the reaction: oxidosqualene = marneral."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25884", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.11", "l": "\"N-succinylornithine carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404140", "l": "NREH hydrolyses atREs to atROL and FAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265301", "l": "Corticotropin cleavage from POMC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382058", "l": "Nck binds to the active PDGF receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211950", "l": "CYP24A1 24-hydroxylates CTL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204824", "l": "Interaction of Tie2 and Ang4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.552154022789225", "identifiers": [{"i": "GO:0061134", "l": "peptidase regulator activity", "d": ["Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632766", "l": "TP53 stimulates SCO2 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32721", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26329", "l": "(8S)-8-amino-7-oxononanoate + L-lysine = (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": [], "t": []}, {"i": "EC:2.6.1.105", "l": "\"lysine--8-amino-7-oxononanoate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351936", "l": "Caspase-mediated cleavage of claspin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36599", "l": "hydrogen sulfide + NAD(+) = NADH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786421", "l": "CHIA hydrolyses chitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66662", "l": "ADP + beta-D-glucosylceramide(out) + H(+) + phosphate => ATP + beta-D-glucosylceramide(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58014", "l": "2 5'-hydroxy-diadenylate 2',3'-cylic phosphate => cyclic tetraadenylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444691", "l": "Prokineticin receptors bind prokineticin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35308", "l": "H(+) + NADH + O2 + salicylate => 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102062", "l": "alpha-santalene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-alpha-santalene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662473", "l": "KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18428", "l": "L-quinate + NADP(+) <=> 3-dehydroquinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71875", "l": "2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954082", "l": "E2F6 binds the PRC1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37546", "l": "2-amino-5-chlorophenol + O2 <=> 2-amino-5-chloromuconate 6-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111264", "l": "Addition of nucleotides between position +11 and +30 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953037", "l": "E2F8 forms homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1878002", "l": "XYLTs transfer Xyl to core protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61139", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + quercetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37600", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617413", "l": "Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67018", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58191", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O <=> dihydroisopentenyldehydrorhodopin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13855", "l": "4-methylene-L-glutamine + AMP + diphosphate + H(+) => 4-methylene-L-glutamate + ATP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033937", "l": "3-deoxy-2-octulosonidase activity", "d": ["Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033775", "l": "deoxysarpagine hydroxylase activity", "d": ["Catalysis of the reaction: 10-deoxysarpagine + H+ + NADPH + O2 = H2O + NADP+ + sarpagine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42673", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12176", "l": "phenylethanolamine + S-adenosyl-L-methionine = H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0106413", "l": "RNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: RNA-uracil + NAD(P)+ = RNA-dihydrouridine + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58715", "l": "NADH + O2 + rifampicin <=> H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17128", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine <=> 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0000033", "l": "alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66080", "l": "2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5686430", "l": "MUS81 binds EME1, EME2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176445", "l": "SMURF2 binds SMAD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29867", "l": "AMP + ITP = ADP + IDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48498", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18648", "l": "2 putrescine <=> NH4(+) + sym-homospermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2574845", "l": "AJUBA binds centrosome-associated AURKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68595", "l": "ORC2 binds ORC3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.300839195380277", "identifiers": [{"i": "GO:0015278", "l": "calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."], "t": []}, {"i": "REACT:R-HSA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011950", "l": "Estrogen-responsive GREB1 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30496", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112385", "l": "Addition of nucleotides leads to transcript elongation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444523", "l": "CXCR5 binds CXCL13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44555", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49901", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 => H2O2 + phenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65393", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH => (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51618", "l": "CO2 + dATP + H2O => ATP + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42260", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] = 3-oxononanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784959", "l": "BPHL hydrolyses VACV to ACV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31620", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875817", "l": "MET phosphorylates STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.-", "l": "\"Endoribonucleases producing other than 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74363", "l": "coproporphyrin III(out) = coproporphyrin III(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69111", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453200", "l": "SYK autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63452", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized 3PG-factor420-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21361", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) => diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043739", "l": "G/U mismatch-specific uracil-DNA glycosylase activity", "d": ["Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil and leaving an apyrimidinic (AP) site."], "t": []}, {"i": "EC:3.2.2.28", "l": "\"double-stranded uracil-DNA glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11078", "l": "catechol + CO2 + NAD(+) + NH4(+) => anthranilate + 3 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608862", "l": "SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218805", "l": "PKC autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41702", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19723", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63266", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0046975", "l": "histone H3K36 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840949", "l": "ARSA removes sulfate from SM3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29087", "l": "(S)-malate + menaquinone-8 = menaquinol-8 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047574", "l": "4-acetamidobutyryl-CoA deacetylase activity", "d": ["Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014294", "l": "RAC2 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70561", "l": "L-threonyl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19407", "l": "(3S)-citryl-CoA + acetate => acetyl-CoA + citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35577", "l": "(1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.86", "l": "\"ketol-acid reductoisomerase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42123", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63820", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + petrobactin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50493", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69593", "l": "CMP + inosine => cytidine + IMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.76", "l": "\"myeloblastin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.25", "l": "\"thiomorpholine-carboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.99", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.29", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13115", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADPH => 2-acetamidofluorene + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33497", "l": "3-heptaprenyl-sn-glycero-1-phosphate + diphosphate => all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28470", "l": "pyridoxine(in) = pyridoxine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983144", "l": "Transport of Antigen peptide in to ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66319", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O <=> alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13850", "l": "D-arabinose => D-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.25", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30225", "l": "2 Fe(II)-[cytochrome c] + H(+) + sulfur => 2 Fe(III)-[cytochrome c] + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937989", "l": "RUNX1 binds PRC1 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31611", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = H2O + rhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33545", "l": "ergosterol + H(+) + hexadecanoate => ergosteryl palmitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42632", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.224", "l": "\"23S rRNA (adenine(2503)-C(8))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49365", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666001", "l": "Profilin:G-actin binds MKL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67465", "l": "H2O + propanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917700", "l": "MVB Vesicle Formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373342", "l": "CX3CR1 binds CX3CL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421493", "l": "succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14504", "l": "H2O + L-homocysteine <=> 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46154", "l": "15,9'-di-cis-phytofluene + a plastoquinol => 15-cis-phytoene + a plastoquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429643", "l": "NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46057", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372723", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22611", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55806", "l": "(9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+) => (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218812", "l": "FYN phosphorylates PAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3878123", "l": "Initiation of SAHF formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77094", "l": "Formation of cap binding complex (CBC) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111879", "l": "PIP2 hydrolysis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60288", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.366", "l": "\"[histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102653", "l": "gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 = H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16271", "l": "4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH => aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33720", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114684", "l": "Phosphorylation of Syntaxin-4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080098", "l": "L-tyrosine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47318", "l": "(2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109807", "l": "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59998", "l": "(E)-cinnamate + reduced [electron-transfer flavoprotein] => 3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30035", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 = benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67859", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11106", "l": "H(+) + hercynine + S-adenosyl-L-homocysteine => N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008968", "l": "D-sedoheptulose 7-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49302", "l": "alpha-maltose 6'-phosphate(in) + L-histidyl-[protein] => D-maltose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030107", "l": "HLA-A specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28462", "l": "pyridoxal(in) = pyridoxal(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30516", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40240", "l": "ATP + CoA + dodecanedioate => AMP + diphosphate + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25635", "l": "H(+) + S-adenosyl-L-homocysteine + syringetin => laricitrin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10110", "l": "H(+) + NADPH + salutaridine => (7S)-salutaridinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809309", "l": "MTMR6 binds MTMR9 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46105", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68595", "l": "ORC2 binds ORC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34847", "l": "7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": [], "t": []}, {"i": "EC:1.5.1.50", "l": "\"dihydromonapterin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008714", "l": "AMP nucleosidase activity", "d": ["Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444523", "l": "CXCR5 binds CXCL13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44599", "l": "a fatty acyl-[ACP] + H2O <=> a fatty acid + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40377", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163310", "l": "TFAM binds to mitochondrial promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354289", "l": "AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46866", "l": "a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789092", "l": "NOX2 generates superoxide anion from oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667563", "l": "AVPR2 bind desmopressin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33177", "l": "4-hydroxyphenylacetate(out) => 4-hydroxyphenylacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61123", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030342", "l": "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40450", "l": "(2R)-pristanoyl-CoA <=> (2S)-pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875183", "l": "CBL monoubiquitinates activated MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27764", "l": "CMP + diphosphate + H(+) => CTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34612", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose => H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102480", "l": "5-fluorocytosine deaminase activity", "d": ["Catalysis of the reaction: H+ + flucytosine + H2O = 5-fluorouracil + ammonium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16494", "l": "glycerol 1,2-cyclic phosphate + H2O => glycerol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27821", "l": "L-idonate + NAD(+) <=> 2-dehydro-L-idonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047464", "l": "heparosan-N-sulfate-glucuronate 5-epimerase activity", "d": ["Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797766", "l": "TP53 binds the BIRC5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50233", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297333", "l": "Association of Acrosin Heavy and Light Chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62307", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine <=> (+)-premalbrancheamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67010", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76415", "l": "3',3'-cGAMP(out) + n H(+)(out) = 3',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982617", "l": "CYGB:O2 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948136", "l": "ULK1 Translocates to the mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17059", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP] => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39198", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213464", "l": "RIPK1 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21375", "l": "H(+) + H2O + urethane <=> CO2 + ethanol + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.3", "l": "\"mitochondrial protein-transporting ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37167", "l": "(2E,6E)-farnesol + NAD(+) = (2E,6E)-farnesal + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.354", "l": "\"farnesol dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68935", "l": "ATP + H(+) + NADPH + octanoate <=> AMP + diphosphate + NADP(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38978", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66120", "l": "2-oxobutanoate + L-methionine = (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55993", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48773", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a => 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41418", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60390", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) => Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863494", "l": "ASICs bind STOML3, (STOM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24552", "l": "5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296045", "l": "Activation of Potassium transport channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928614", "l": "EFNB:GRB4 binds GIT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5225649", "l": "RBBP7 binds histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.5", "l": "\"deoxyribonuclease X\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40269", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050395", "l": "vitexin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + vitexin = H+ + UDP + vitexin 2''-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761421", "l": "CDH11 associates with catenins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25153", "l": "2-oxoglutarate + L-phenylalanine => 3-phenylpyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75570", "l": "acetyl-CoA + cyathatriol <=> 11-O-acetylcyathatriol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29361", "l": "phosphate + uridine => H2O + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55832", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42842", "l": "2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+) => acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75094", "l": "2 chloride(in) + sulfate(out) <=> 2 chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426032", "l": "DAG is metabolized by DAGL to 2-AG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052656", "l": "L-isoleucine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22275", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37511", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66187", "l": "3',5'-cyclic AMP(in) + ATP + H2O <=> 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28688", "l": "(S)-dihydroorotate + ubiquinone-8 => orotate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847912", "l": "PNPLA7 hydrolyzes LysoPtdCho (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66412", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48610", "l": "a 2,3-dehydroacyl-CoA + AH2 => A + a 2,3-saturated acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65192", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A = berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670114", "l": "Histone H3.3 deposition at telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49206", "l": "20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112436", "l": "Formation of Elongin complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.59", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68563", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) <=> 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63360", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264865", "l": "Caspase-mediated cleavage of Lamin A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43791", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O <=> ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59411", "l": "H2O + N-acetyl-L-aspartate <=> acetate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17431", "l": "4-oxocyclohexanecarboxylate + H(+) + NADH => NAD(+) + trans-4-hydroxycyclohexanecarboxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37353", "l": "cytidine + phosphate => cytidine 2'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168923", "l": "Collagen type XVIII endostatin release (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48823", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70380", "l": "3-oxosphinganine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38036", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate => (4Z)-2-oxohept-4-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984963", "l": "EBI3 gene transcription and translation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42847", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10685", "l": "H2O + O-phospho-L-tyrosyl-[protein] => L-tyrosyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58138", "l": "acetyl-AMP + diphosphate => acetate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390673", "l": "CHRM2,4 bind acetylcholine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61078", "l": "(-)-echitovenine + CoA => (-)-minovincinine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047911", "l": "galacturan 1,4-alpha-galacturonidase activity", "d": ["Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43430", "l": "1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-didecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65488", "l": "3 ATP = 2',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73710", "l": "ATP(in) + UDP(out) <=> ATP(out) + UDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54827", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] <=> alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31779", "l": "an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.90", "l": "\"all-trans-retinyl ester 13-cis isomerohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56449", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168885", "l": "Haptoglobin binds Hemoglobin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008899", "l": "homoserine O-succinyltransferase activity", "d": ["Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983700", "l": "SYK binds the activated BCR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004483", "l": "mRNA (nucleoside-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76456", "l": "O-atom dealkylation of dextromethorphan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46963", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49109", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58484", "l": "H2O + N-(acetyl)-sphing-4-enine = acetate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668714", "l": "RAC1:GTP binds NOX1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613530", "l": "PRKAA2 phosphorylates PLINs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400492", "l": "PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69299", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43742", "l": "AMP + diphosphate + hexanoyl-CoA => ATP + CoA + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653974", "l": "Ragulator binds Rag dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33772", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56878", "l": "(R)-1-phenylethylamine + acetate => (R)-N-acetyl-1-phenylethylamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177930", "l": "GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317332", "l": "PIP3 recruits AKT to the membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39714", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29641", "l": "alpha-D-glucose + D-maltopentaose => D-maltohexaose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17506", "l": "H2O + N-(long-chain fatty acyl)ethanolamine => a long-chain fatty acid + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60111", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA <=> (E)-4-coumaroyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001078", "l": "(1->6)-beta-D-glucan binding", "d": ["Binding to (1->6)-beta-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483174", "l": "PE is methylated to PC by PEMT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49430", "l": "CMP-5'-phosphonoformate + diphosphate => CTP + phosphonoformate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41933", "l": "H2O + hexadecanoyl-[ACP] => H(+) + hexadecanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22862", "l": "deamido-NAD(+) + diphosphate => ATP + H(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655247", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17369", "l": "glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": [], "t": []}, {"i": "EC:3.2.1.128", "l": "\"glycyrrhizinate beta-glucuronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45427", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16562", "l": "H2O + squalene => hopan-22-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44531", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54076", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + stellata-2,6,19-triene", "d": [], "t": []}, {"i": "EC:4.2.3.178", "l": "\"stellata-2,6,19-triene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033963", "l": "cholesterol-5,6-oxide hydrolase activity", "d": ["Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60421", "l": "H2O + triglucosyl-enterobactin => [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681980", "l": "ATG12 binds ATG7 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19224", "l": "2 formaldehyde + H2O <=> formate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54974", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696980", "l": "Spike trimer glycoside chains get additional branches (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29890", "l": "ATP + H2O + L-lysine(out) <=> ADP + H(+) + L-lysine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70289", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,6-trisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70014", "l": "2-aminobenzoyl-AMP + CoA <=> AMP + anthraniloyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005141", "l": "interleukin-10 receptor binding", "d": ["Binding to an interleukin-10 receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42216", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66669", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65278", "l": "2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728150", "l": "SLC5A2 binds gliflozins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70881", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(in) => L-glutamine(in) + L-threonine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74898", "l": "nitric oxide(out) <=> nitric oxide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45998", "l": "a 2-oxocarboxylate + a quinol + NH4(+) => a D-alpha-amino acid + a quinone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59633", "l": "D-xylobiose + O2 => D-xylobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76066", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) <=> 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76194", "l": "carnosine(out) + 2 H(+)(out) <=> carnosine(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74730", "l": "Insulin degradation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13170", "l": "maleate => fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60795", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 <=> 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944220", "l": "Association of procollagen type XXIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863727", "l": "STON2 is neddylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34581", "l": "2 CO2 + H2O + pentalenolactone F + 2 succinate => 2 2-oxoglutarate + 2 O2 + pentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168860", "l": "Membrane fusion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14749", "l": "1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.38", "l": "\"1-hydroxy-2-naphthoate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37598", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55445", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23198", "l": "3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine => 3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3782637", "l": "HDAC8 deacetylates histones (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16865", "l": "choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10673", "l": "cyclobutadithymidine in DNA => a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24685", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46583", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 <=> 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60929", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40334", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47262", "l": "16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043749", "l": "phenol, water dikinase activity", "d": ["Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698962", "l": "Binding of pPR-AP to pAP to form the pPR-AP:pAP Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16521", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888577", "l": "Synthesis of GABA by GAD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70194", "l": "ATP + NAD(+) <=> 3'-NADP(+) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47928", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) = (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624949", "l": "Assembly of the anterograde IFT train (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0097621", "l": "monoamine oxidase activity", "d": ["Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939335", "l": "RNF181 polyubiquinates BCL10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0048531", "l": "beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112396", "l": "Separation of elongating transcript from template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141439", "l": "Release of activated MAD2 from kinetochores (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24741", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0008409", "l": "5'-3' exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952371", "l": "MDM2 binds RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420975", "l": "Ca impermeable AMPA receptor ligand binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39986", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140414", "l": "phosphopantetheine-dependent carrier activity", "d": ["Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210700", "l": "KEN dimer represses transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186780", "l": "Degradation of Ub-SMAD7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0000992", "l": "RNA polymerase III cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875661", "l": "GGA3 associates with activated MET receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681616", "l": "AP2 binds chlorpromazine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69151", "l": "H2O + O2 + spermine <=> H2O2 + NH4(+) + spermine monoaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22637", "l": "dCTP + H2O => dCMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19818", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20910", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50891", "l": "an N-acylsphingoid base 1-phosphate + H2O <=> an N-acyl-sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40502", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70038", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852019", "l": "MET bound PI3K generates PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033837", "l": "anthocyanin 3'-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033440", "l": "ACG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72932", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] => atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0008227", "l": "G protein-coupled amine receptor activity", "d": ["Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25502", "l": "diphosphate + terpinolene => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624256", "l": "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709547", "l": "ESTG binds ESR2:chaperone complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380949", "l": "AMPK is dephosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110236", "l": "OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23005", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40926", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17392", "l": "D-arabinitol + NAD(+) <=> D-ribulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602984", "l": "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0019798", "l": "procollagen-proline dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42861", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22833", "l": "H2O + N-formimidoyl-L-glutamate => N-formyl-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23607", "l": "kievitone hydrate <=> H2O + kievitone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444047", "l": "Receptor FFAR3 binds carboxylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76769", "l": "physcion + S-adenosyl-L-homocysteine => emodin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67255", "l": "H2O + malonaldehyde + NAD(+) <=> 3-oxopropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15476", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72994", "l": "2 Na(+)(out) + scyllo-inositol(out) <=> 2 Na(+)(in) + scyllo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381203", "l": "XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19474", "l": "4-hydroxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62002", "l": "3 AH2 + protoporphyrin IX => 3 A + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629004", "l": "Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36117", "l": "O-methyl gibberellin A3 + S-adenosyl-L-homocysteine => gibberellin A3 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47261", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.49", "l": "\"hypodermin C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210295", "l": "Interaction of DAP12 and NKG2D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34953", "l": "3-hydroxypropanoate(in) => 3-hydroxypropanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50797", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48968", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633241", "l": "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55499", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795667", "l": "MDM2 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30423", "l": "(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.76", "l": "\"(+)-delta-selinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214859", "l": "Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451311", "l": "Activation of Ca-permeable Kainate receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0003896", "l": "DNA primase activity", "d": ["Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases."], "t": []}, {"i": "EC:2.7.7.101", "l": "\"DNA primase DnaG\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005980", "l": "IL21 binds IL21R:JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67220", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102047", "l": "indole-3-acetyl-glycine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) = H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76015", "l": "(3R)-hydroxybutanoate trimer + H2O = (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204873", "l": "Interaction of Tie2 and Shp2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956427", "l": "RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44332", "l": "ATP + L-alanine + L-anticapsin = ADP + bacilysin + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.49", "l": "\"L-alanine--L-anticapsin ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202726", "l": "F11R dimerises (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853792", "l": "RET tyrosine phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49353", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68652", "l": "2 L-homocysteine = H(+) + hydrogen sulfide + L-homolanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982637", "l": "Opsins binds G alpha-t (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176116", "l": "Recruitment and activation of Chk1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420724", "l": "CASR binds Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534096", "l": "METAP1/2 demethylates GNAT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62555", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39655", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001618", "l": "virus receptor activity", "d": ["Combining with a virus component and mediating entry of the virus into the cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680443", "l": "ROCK1,2 bind ROCKi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102521", "l": "tRNA-4-demethylwyosine synthase activity", "d": ["Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55579", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine <=> H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60607", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74282", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA <=> a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050532", "l": "2-phosphosulfolactate phosphatase activity", "d": ["Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61304", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24762", "l": "3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+) => H(+) + L-dopa + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098601", "l": "selenomethionine adenosyltransferase activity", "d": ["Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70039", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26292", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57741", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) => a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509827", "l": "ITPA hydrolyses ITP to IMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3782655", "l": "HDAC10 deacetylates histone (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18372", "l": "O2 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710354", "l": "GSDME (1-270) binds cardiolipin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.134", "l": "\"galactolipid O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74730", "l": "Insulin degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046922", "l": "peptide-O-fucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40881", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70466", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76267", "l": "carnosine(in) = carnosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.96", "l": "\"D-aminoacyl-tRNA deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578777", "l": "DMPK phosphorylates PLN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55451", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76471", "l": "AH2 + cob(III)alamin = A + cob(I)alamin + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804402", "l": "TP53 binds POU4F1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52704", "l": "H2O + UMP = D-ribose 5-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036401", "l": "pyrokinin receptor activity", "d": ["Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797090", "l": "CCNK binds CDK12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836606", "l": "SPHK1 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629679", "l": "PDE3A inhibitors bind PDE3A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26330", "l": "(8S)-8-amino-7-oxononanoate + L-lysine => (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23469", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 => 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21851", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide <=> (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030619", "l": "U1 snRNA binding", "d": ["Binding to a U1 small nuclear RNA (U1 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76636", "l": "n H(+)(out) + Mn(2+)(in) => n H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004919", "l": "interleukin-9 receptor activity", "d": ["Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.-", "l": "\"Exodeoxyribonucleases producing 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68101", "l": "NAD(+) + xylitol => H(+) + L-xylulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172433", "l": "Collagen type XIX degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032003", "l": "interleukin-28 receptor binding", "d": ["Binding to an interleukin-28 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57499", "l": "2-methylcitrate <=> 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710106", "l": "ELANE cleaves GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626928", "l": "CREBBP binds FOXO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672196", "l": "Viral serpin blocks caspase-8 activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004137", "l": "deoxycytidine kinase activity", "d": ["Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64721", "l": "H(+)(out) + pyruvate(out) => H(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51558", "l": "(S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine => (S)-glaucine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59086", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102394", "l": "4-hydroxy-L-isoleucine dehydrogenase activity", "d": ["Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD = (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27915", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16952", "l": "myo-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12358", "l": "D-fructose 6-phosphate => D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21919", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O <=> an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2484822", "l": "Kinetochore assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28467", "l": "pyridoxamine(in) => pyridoxamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618479", "l": "ABCA1 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18726", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49316", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984733", "l": "Kinesin-3 is a dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694441", "l": "3CLp cleaves pp1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821395", "l": "PAXIP1 binds PAGR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77309", "l": "5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine => N(omega),N('omega)-dimethyl-L-arginine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983707", "l": "SYK autophosphorylates at the activated BCR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35618", "l": "hydroxyacetone + NAD(+) <=> H(+) + methylglyoxal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31944", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53607", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483186", "l": "PC is converted to PS by PTDSS1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34165", "l": "(2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+) => hydroquinone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683879", "l": "SFTPA genes produce SFTPA proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77405", "l": "(2S)-2-hydroxy-3-methylbutanenitrile => 2-methylpropanal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32091", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.278", "l": "\"3-alpha-mycarosylerythronolide B desosaminyl transferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570528", "l": "SUMOylation of XPC with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374677", "l": "L1 binds ERM family members (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.26", "l": "\"pseudolysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:1901375", "l": "acetate ester transmembrane transporter activity", "d": ["Enables the transfer of an acetate ester from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72214", "l": "(+)-isoborneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11151", "l": "4 Fe(2+) + 4 H(+) + O2 <=> 4 Fe(3+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14934", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211350", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015026", "l": "coreceptor activity", "d": ["Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009025", "l": "tagatose-bisphosphate aldolase activity", "d": ["Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24030", "l": "carnitine + CO2 + succinate => 2-oxoglutarate + 4-(trimethylamino)butanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61475", "l": "a sphingoid base + hexadecanoyl-CoA <=> an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015346", "l": "ferric triacetylfusarinine C:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008686", "l": "3,4-dihydroxy-2-butanone-4-phosphate synthase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53486", "l": "17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+) => androst-4-ene-3,11,17-trione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213017", "l": "Auto-ubiquitination of TRAF3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55036", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74500", "l": "H(+) + NADPH + yaequinolone D => H2O + NADP(+) + penigequinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13655", "l": "[6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose => [6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061649", "l": "ubiquitin modification-dependent histone binding", "d": ["Binding to a histone protein in which a residue has been modified by ubiquitination."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70701", "l": "H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47244", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33650", "l": "(9Z)-hexadecenoate + ATP + CoA <=> (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653894", "l": "Expression of CHAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15331", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADH => (S)-ureidoglycolate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46577", "l": "H(+) + NADPH + O2 + sitosterol => 2 H2O + NADP(+) + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69298", "l": "3-hydroxypent-4-ene nitrile + sulfate + sulfur => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76782", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,6-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24642", "l": "D-glucose + ergosterol => ergosteryl 3-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948757", "l": "AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41045", "l": "1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937807", "l": "SRC phosphorylates RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34431", "l": "(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.23.1.4", "l": "\"(-)-lariciresinol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865454", "l": "CBFB binds RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37662", "l": "anthraniloyl-CoA + methanol <=> CoA + O-methyl anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862300", "l": "LYZ binds bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689000", "l": "AADAC deacetylates PHEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848774", "l": "PTK6 binds DOK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66925", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA => [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47163", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14611", "l": "H(+) + keto-L-sorbose + NADPH => D-sorbitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38089", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64594", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211224", "l": "Association of DFF40 with DFF45 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69006", "l": "AMP + cremeomycin + diphosphate + H2O => 3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18271", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (S)-3-hydroxyhexanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73104", "l": "diosmetin + S-adenosyl-L-methionine => luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836899", "l": "sG binds to HSPGs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68383", "l": "3-hydroxypyruvate + L-asparagine <=> 2-oxosuccinamate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928576", "l": "RHOA:GTP binds ROCK, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0034338", "l": "short-chain carboxylesterase activity", "d": ["Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649735", "l": "Intrinsic nucleotide exchange on RAS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70830", "l": "L-arginine(in) + L-lysine(out) <=> L-arginine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004466", "l": "long-chain fatty acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46822", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27817", "l": "acetate(in) + Na(+)(in) <=> acetate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15094", "l": "2-oxoglutarate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.145", "l": "\"deoxynucleoside kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71985", "l": "diphosphate + fusoxypene B => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043795", "l": "glyceraldehyde oxidoreductase activity", "d": ["Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58328", "l": "(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879221", "l": "PSTPIP1 binds Pyrin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74717", "l": "3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372855", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34427", "l": "(-)-lariciresinol + NADP(+) = (-)-pinoresinol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.23.1.3", "l": "\"(-)-pinoresinol reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008097", "l": "5S rRNA binding", "d": ["Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047319", "l": "aspartate-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74767", "l": "S-adenosyl-L-methionine + syringetin = 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608288", "l": "Defective MUTYH mutants do not bind adenine mispaired with 8-oxoguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983707", "l": "SYK autophosphorylates at the activated BCR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76761", "l": "1,5-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381091", "l": "IRE1 dimer autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29726", "l": "glyoxylate(in) <=> glyoxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48548", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.89", "l": "\"protein phosphatase methylesterase-1\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52219", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O <=> [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11869", "l": "D-arabinitol + NADP(+) => D-ribulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53715", "l": "2 Fe(III)-heme b <=> beta-hematin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75928", "l": "cyclohexylamine + H2O + NAD(+) => cyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48284", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161673", "l": "PGD2 is dehydrated to 15d-PGD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036121", "l": "double-stranded DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24781", "l": "C-13(2)-carboxypyropheophorbide a + H(+) => CO2 + pyropheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48509", "l": "cholate + NADP(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37204", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022141", "l": "Prolysyl oxidase activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66505", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17248", "l": "3-hydroxyanthranilate + O2 <=> 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939088", "l": "CR1 gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76655", "l": "3-methylbutanal + H2O + NAD(+) = 3-methylbutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52917", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38342", "l": "(20S)-ginsenoside Rb1 + H2O <=> (20S)-ginsenoside Rd + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49866", "l": "(+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (+)-dehydrodiconiferyl acid + 2 a quinone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62655", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191299", "l": "Squalene is oxidized to its epoxide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48524", "l": "a ganglioside GP1c + H2O = a ganglioside GQ1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426146", "l": "SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59953", "l": "2,6-dimethylheptanoyl-CoA + H2O => 2,6-dimethylheptanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11063", "l": "ATP + L-isoleucine + tRNA(Ile) <=> AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977959", "l": "ERBB4 forms heterodimers with EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.48", "l": "\"15-oxoprostaglandin 13-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41917", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47415", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029471", "l": "Hydrolysis of PC to PA by PLD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018826", "l": "RHOT2 hydrolyzes GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58723", "l": "(S)-nicotine + NADPH + O2 <=> H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33468", "l": "5-dehydroepisterol + H(+) + NADPH + O2 => ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66250", "l": "AMP + H(+) + IC-asc-C9-CoA => CoA + IC-asc-C9-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.874891891299569", "identifiers": [{"i": "GO:0015399", "l": "primary active transmembrane transporter activity", "d": ["Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51857", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) => (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34690", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 <=> A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43993", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 => 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33162", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43214", "l": "2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005091", "l": "guanyl-nucleotide exchange factor adaptor activity", "d": ["The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11252", "l": "H(+) + hydroxylamine + L-asparagine = beta-L-aspartylhydroxamate + NH4(+)", "d": [], "t": []}, {"i": "EC:2.3.2.7", "l": "\"aspartyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63032", "l": "a fatty acylamide + H2O = a fatty acid + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867613", "l": "PICALM binds R-SNAREs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42417", "l": "a ubiquinone + L-proline => (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31441", "l": "alpha-longipinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57443", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] <=> 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653957", "l": "Rag dimer formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.755473255981116", "identifiers": [{"i": "GO:0004396", "l": "hexokinase activity", "d": ["Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32615", "l": "(6E)-8-oxogeraniol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30185", "l": "H(+) + keto-D-tagaturonate + NADH => L-galactonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428123", "l": "KDSR reduces 3-ketosphingoid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033464", "l": "GGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102592", "l": "delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose = violdelphin + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42068", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH = clavulanate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20369", "l": "betaine aldehyde + H2O + O2 = glycine betaine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14357", "l": "ATP + riboflavin = ADP + FMN + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.26", "l": "\"riboflavin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840795", "l": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62236", "l": "a cytidine(6-4)cytidine in DNA = a cytidine dimer in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43810", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62765", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051539", "l": "4 iron, 4 sulfur cluster binding", "d": ["Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25096", "l": "ADP + dCDP => ATP + dCMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2214351", "l": "PLK1 phosphorylates GORASP1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77570", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67476", "l": "dimethylallyl diphosphate + L-glutamate = diphosphate + prekainate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12050", "l": "3-oxoadipyl-CoA + succinate => 3-oxoadipate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63922", "l": "CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine => octadecanoyl-CoA + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50167", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35673", "l": "(1'S,5'S)-averufin + H2O => (S)-5'-oxoaverantin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850961", "l": "PREX2 binds PTEN and inhibits it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31138", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate <=> 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28042", "l": "CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.104", "l": "\"pyruvate dehydrogenase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74183", "l": "S-adenosyl-L-methionine + taxifolin = H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54207", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669012", "l": "EDA binds EDAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16471", "l": "(R)-2-benzylsuccinyl-CoA + succinate => (R)-2-benzylsuccinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10115", "l": "L-homocysteine + L-serine <=> H2O + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11329", "l": "dimethylallyl diphosphate + isopentenyl diphosphate => diphosphate + neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22525", "l": "2 A + a carotenoid beta-end derivative => a carotenoid phi-end derivative + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655847", "l": "Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21910", "l": "H(+) + NADPH + naphthalene-1,3,6,8-tetrol => NADP(+) + scytalone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55196", "l": "2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43934", "l": "androst-5-ene-3,17-dione + H(+) + NADH => 3beta-hydroxyandrost-5-en-17-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36343", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 = 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696323", "l": "CNRs bind CNR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40754", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69299", "l": "CDT1 binds geminin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73120", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57062", "l": "acetate + ADP-D-ribose + H(+) => 2''-O-acetyl-ADP-D-ribose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75532", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine => A + H2O + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004639", "l": "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25694", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.81", "l": "\"geranylfarnesyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044105", "l": "L-xylulose reductase (NAD+) activity", "d": ["Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41350", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56761", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55125", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH => 5-methylhexanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784959", "l": "BPHL hydrolyses VACV to ACV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49784", "l": "chenodeoxycholoyl-CoA + taurine = CoA + H(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74286", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA <=> a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.330956682939657", "identifiers": [{"i": "GO:0004857", "l": "enzyme inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.42", "l": "\"Kdo2-lipid A phosphoethanolamine 7''-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044876", "l": "hercynylselenocysteine synthase", "d": ["Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 = 2 H2O + 2 hercynylselenocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72502", "l": "2-oxoglutarate(in) + prostaglandin E2(out) <=> 2-oxoglutarate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59576", "l": "anserine + H2O = beta-alanine + N(pros)-methyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55095", "l": "D-fructose + UDP-alpha-D-glucose <=> H(+) + sucrose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23326", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide => 2'-phospho-[ligated tRNA] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.54", "l": "\"calpain-3\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44084", "l": "ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29215", "l": "fumarate + menaquinol-8 = menaquinone-8 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54067", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-cubebol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55535", "l": "H(+) + H2O + L-phenylalanine + O2 <=> 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983259", "l": "Kinesins move along microtubules consuming ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41856", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622134", "l": "CRABP1 binds atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34485", "l": "4-hydroxybenzalacetone + 2 CO2 + 2 CoA => 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55321", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29600", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55289", "l": "tetradecan-1-ol + tetradecanoyl-CoA => CoA + tetradecanyl tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202969", "l": "Caspase mediated cleavage of beta-catenin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548890", "l": "Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9737780", "l": "MTTP binds lomitapide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15106", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68229", "l": "glycine(in) + Na(+)(in) => glycine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698930", "l": "HCMV C Nucleocapsid Translocation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43533", "l": "a ribonucleoside 3',5'-bisphosphate + H2O => a ribonucleoside 5'-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008418", "l": "protein-N-terminal asparagine amidohydrolase activity", "d": ["Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67539", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77482", "l": "hexan-2-one + hydrogen cyanide <=> (2S)-2-hydroxy-2-methylhexanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655142", "l": "RCHY1 binds POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52027", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> 18S-resolvin E2 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38055", "l": "CTP + phytol = CDP + H(+) + phytyl phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.182", "l": "\"phytol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67590", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71509", "l": "(+)-alpha-tocopherol(in) => (+)-alpha-tocopherol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47204", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57567", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15013", "l": "3alpha(S)-strictosidine + H2O = secologanin + tryptamine", "d": [], "t": []}, {"i": "EC:4.3.3.2", "l": "\"strictosidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35838", "l": "2'-dehydrokanamycin A + H(+) + NADPH <=> kanamycin A + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68086", "l": "diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => GTP + L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74283", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004377", "l": "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56122", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-heptaprenylphenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73841", "l": "AMP + 2 H(+) + phenyl phosphate + phosphate => ATP + H2O + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.9", "l": "\"tripeptidyl-peptidase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63847", "l": "[thioredoxin]-dithiol + cumene hydroperoxide <=> 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55614", "l": "1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75927", "l": "cyclohexylamine + H2O + NAD(+) = cyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22101", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O => 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77134", "l": "1D-myo-inositol 1,2,6-trisphosphate + H2O <=> 1D-myo-inositol 1,2-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43978", "l": "14-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769235", "l": "MAGED1 binds NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31312", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76013", "l": "(3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate tetramer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29384", "l": "dIMP + H2O => 2'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24606", "l": "H(+) + S-adenosyl-L-homocysteine + theobromine => 7-methylxanthine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75162", "l": "NAD(+) + TTP <=> H(+) + NADP(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66528", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15859", "l": "17alpha-hydroxyprogesterone + H(+) + NADPH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432535", "l": "TIM is phosphorylated by CK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018708", "l": "thiol S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852324", "l": "GTSE1 binds PLK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60259", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34385", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52678", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine => [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23517", "l": "(R)-glycerate + ATP => (2R)-3-phosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55656", "l": "2 A + a carotenoid beta-end derivative = a carotenoid chi-end derivative + 2 AH2", "d": [], "t": []}, {"i": "EC:1.3.99.40", "l": "\"carotenoid chi-ring synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177934", "l": "EGFR autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046988", "l": "asioloorosomucoid beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635839", "l": "ULK3:SUFU dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354077", "l": "Integrin alphaIIb beta3 activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23424", "l": "alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:5.4.2.10", "l": "\"phosphoglucosamine mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32659", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.324", "l": "\"8-hydroxygeraniol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005152", "l": "interleukin-1 receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to the interleukin-1 receptor complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140829", "l": "bicarbonate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in)."], "t": []}, {"i": "TCDB:2.A.31.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54849", "l": "H(+) + hexan-3-one + NADPH + O2 => H2O + NADP(+) + propyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755303", "l": "26S proteasome degrades HIFalpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17924", "l": "D-arabinitol + NAD(+) <=> D-xylulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65745", "l": "2-oxoglutarate + decyl sulfate + O2 => CO2 + decanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10800", "l": "diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": [], "t": []}, {"i": "EC:2.4.2.22", "l": "\"xanthine phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781941", "l": "WNTs are secreted in exosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014433", "l": "RHOG GEFs activate RHOG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39082", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) <=> 3-oxododecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24572", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose = [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}, {"i": "EC:2.4.1.4", "l": "\"amylosucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26037", "l": "3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638104", "l": "UGCG transfers glucose to ceramide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11824", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": [], "t": []}, {"i": "EC:2.1.2.11", "l": "\"3-methyl-2-oxobutanoate hydroxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39368", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31119", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38964", "l": "ATP + H2O + leukotriene C4(in) => ADP + H(+) + leukotriene C4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51112", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67866", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.120", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71501", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362522", "l": "ALDHs oxidise atRAL to atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690785", "l": "BAP1 binds Ub-HCFC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047200", "l": "tetrahydrodipicolinate N-acetyltransferase activity", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46444", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.15", "l": "\"(11Z)-hexadec-11-enoyl-CoA conjugase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202127", "l": "eNOS synthesizes NO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13154", "l": "(R)-glycerate + CO2 + NAD(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41411", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979082", "l": "Phosphorylated ETS2 binds p16INK4A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60841", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849882", "l": "SALMs 1-4 bind reticulon 3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418172", "l": "F2R binds ARRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14480", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66459", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61649", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate => AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432067", "l": "Aquaporin-4 passively transports water out of cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001760", "l": "aminocarboxymuconate-semialdehyde decarboxylase activity", "d": ["Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H+ = 2-aminomuconate 6-semialdehyde + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31167", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388468", "l": "AVP(20-28) binds AVPR1A,B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139920", "l": "Translocation of tBID to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070251", "l": "pristanate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60975", "l": "hexan-1-ol + NAD(+) <=> H(+) + hexanal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662466", "l": "XYLB phosphorylates D-xylulose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193981", "l": "CYP21A2 oxidises 17HPROG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37867", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20940", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62825", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74181", "l": "a ketone + H(+) + NADPH + NH4(+) => a secondary alkyl amine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33793", "l": "beta-D-fructose + beta-D-glucose 6-phosphate => H2O + sucrose 6(F)-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56481", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65406", "l": "butyl hexanoate + CoA => butan-1-ol + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54745", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694567", "l": "pp1a forms a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36387", "l": "carbamoyl adenylate + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853444", "l": "AURKA phosphorylates PHLDA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23711", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20817", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) => 3-oxoglycyrrhetinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54984", "l": "a ubiquinol = a ubiquinone + 2 e(-) + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55559", "l": "a hydroperoxyeicosatetraenoate <=> an oxoeicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429101", "l": "HMIT co-transports myo-inositol with a proton (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051959", "l": "dynein light intermediate chain binding", "d": ["Binding to a light intermediate chain of the dynein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45228", "l": "a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76466", "l": "CYP4A11 12-hydroxylates DDCX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68866", "l": "alpha-D-glucose + D-glucose => H2O + isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140492", "l": "metal-dependent deubiquitinase activity", "d": ["An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61677", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP => AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043791", "l": "dimethylamine methyltransferase activity", "d": ["Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64086", "l": "2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39968", "l": "2-aminobut-2-enoate => 2-iminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665706", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5605147", "l": "Defective CYP1B1 does not 4-hydroxylate EST17b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937037", "l": "RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61161", "l": "quercetin + UDP-beta-L-rhamnose => H(+) + quercitrin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050073", "l": "macrolide 2'-kinase activity", "d": ["Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H+ + oleandomycin 2'-O-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53212", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376126", "l": "DSCAM binds Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736959", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382056", "l": "Crk binds to the active PDGF receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211950", "l": "CYP24A1 24-hydroxylates CTL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69823", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689111", "l": "PARK2 autoubiquitinates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000907", "l": "sulfonate dioxygenase activity", "d": ["Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51642", "l": "(11R)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41218", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848110", "l": "SOCS3 binds activated PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55073", "l": "2-oxobutanoate + H(+) => CO2 + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44579", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) <=> 2-all-trans-nonaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27293", "l": "A + formate + H(+) <=> AH2 + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37905", "l": "H(+) + S-adenosyl-L-homocysteine + tryprostatin A => 6-hydroxytryprostatin B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71199", "l": "L-ornithine(in) = L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70633", "l": "2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50960", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69855", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189381", "l": "BIL translocates from the cytosol to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689649", "l": "BAP1 binds BRCA1:BARD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37034", "l": "D-ribonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052795", "l": "exo-alpha-(2->6)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14542", "l": "choloyl-CoA + H2O => cholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72358", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) <=> dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796617", "l": "MIB2 binds CFLAR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703437", "l": "FLT3 fusion dimers autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090581", "l": "protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57559", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53623", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-spiroviolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72570", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59931", "l": "erythritol + NADP(+) <=> D-erythrose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805792", "l": "p-S291-PHF20 translocates to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693243", "l": "RHOD translocates to the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650858", "l": "Meglitinides bind ABCC8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23328", "l": "a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603419", "l": "Activated NTRK3 binds SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69339", "l": "(E)-alk-1-en-1-SO-peroxol <=> (Z)-alkanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106415", "l": "muramoyltetrapeptide carboxypeptidase activity", "d": ["GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60243", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045131", "l": "pre-mRNA branch point binding", "d": ["Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46121", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56797", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] => adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55933", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O => AMP + H(+) + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22353", "l": "H(+) + L-lysine => cadaverine + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20010", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose => H(+) + linamarin + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21246", "l": "an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781953", "l": "YOD1 binds VCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46075", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH <=> hexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74711", "l": "Phosphorylation of IRS (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67284", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44725", "l": "2,3-saturated fatty aldehyde + NADP(+) => (2E)-fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654545", "l": "Ligand-independent phosphorylation of overexpressed FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74431", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63914", "l": "6-azauridine 5'-phosphate + ADP + H(+) => 6-azauridine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41587", "l": "dimethylallyl diphosphate + L-tyrosine <=> 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70905", "l": "(2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72095", "l": "(S)-carnitine(out) + Na(+)(out) = (S)-carnitine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67489", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934465", "l": "SHC1 binds PTPN12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198508", "l": "MDH1 oxidizes MAL to OA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16523", "l": "NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74403", "l": "2 (S)-lactate(in) + prostaglandin D2(out) = 2 (S)-lactate(out) + prostaglandin D2(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41479", "l": "an acyl-CoA + zymosterol <=> CoA + zymosterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371422", "l": "ATP hydrolysis by HSP70 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17168", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700175", "l": "Active ALK phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59967", "l": "L-seryl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60183", "l": "ATP + D-fructose(out) + H2O <=> ADP + D-fructose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380158", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43607", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.2", "l": "\"exoribonuclease H\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662598", "l": "MT2A binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52918", "l": "16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032775", "l": "YAP1 binds TEAD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30677", "l": "H2O + squalene => tetrahymanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31179", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15904", "l": "(2R)-2-phosphoglycerate <=> (2R)-3-phosphoglycerate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.15", "l": "\"mycothione reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0010340", "l": "carboxyl-O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990600", "l": "single-stranded DNA endodeoxyribonuclease activator activity", "d": ["Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36180", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58998", "l": "H(+) + H2O2 + indole-3-carboxylate => H2O + indole-3-carbaldehyde + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35442", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine <=> archaetidylserine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68773", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46626", "l": "a L-5-monosubstituted hydantoin => a D-5-monosubstituted hydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70106", "l": "H(+) + o-quinone methide + penilactone D <=> penilactone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423632", "l": "AFXBO binds DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34688", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 => A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39160", "l": "(3R)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327733", "l": "FN1 binds Collagen types I-V, VII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45049", "l": "acetamide + H2O => acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17782", "l": "H2O + N-formyl-L-methionine => formate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12321", "l": "17-O-acetylnorajmaline + NADP(+) => 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.4", "l": "\"aldehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58515", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634429", "l": "CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.325027496665193", "identifiers": [{"i": "GO:0008233", "l": "peptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392195", "l": "Gi activation by P2Y purinoceptor 12 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76510", "l": "(-)-2'-epi-GR24 + H2O <=> (-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49508", "l": "phosphinomethylmalate = 2-(phosphinatomethylidene)butanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77589", "l": "Recognition of AAUAAA sequence by CPSF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56368", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50447", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 <=> prostaglandin G3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17406", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine => H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74018", "l": "4-hydroxybenzoate + H(+) + phosphate <=> CO2 + H2O + phenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55387", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate <=> 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75369", "l": "cytidine(out) => cytidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59140", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine = AMP + diphosphate + H(+) + staphyloferrin A", "d": [], "t": []}, {"i": "EC:6.3.2.57", "l": "\"staphyloferrin A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28146", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] = 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.174", "l": "\"geranylhydroquinone 3''-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004415", "l": "hyalurononglucosaminidase activity", "d": ["Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22172", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.14", "l": "\"sucrose-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444691", "l": "Prokineticin receptors bind prokineticin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75743", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH = 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033907", "l": "beta-D-fucosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676229", "l": "WIPIs bind PI3P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46008", "l": "CoA + NAD(+) + pentanal = H(+) + NADH + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661432", "l": "BIL binds ALB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27986", "l": "hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166362", "l": "Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24910", "l": "L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111915", "l": "CAMK4 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43099", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69309", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => phenylacetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830945", "l": "Expression of EYA1 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50889", "l": "an N-acylsphingoid base 1-phosphate + H2O => an N-acyl-sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375140", "l": "CDO binds promyogenic cadherins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990518", "l": "single-stranded 3'-5' DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60739", "l": "(2E,6E)-farnesal + H2O + NADP(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.-", "l": "\"Acting on carbon-sulfur bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097620", "l": "(R)-mandelate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor."], "t": []}, {"i": "RHEA:43112", "l": "(R)-mandelate + NAD(+) = H(+) + NADH + phenylglyoxylate", "d": [], "t": []}, {"i": "EC:1.1.1.379", "l": "\"(R)-mandelate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2299620", "l": "Collagen XI cross-links with collagen II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018445", "l": "prothoracicotrophic hormone activity", "d": ["The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64796", "l": "H2O + L-lysine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73853", "l": "H(+) + UDP + withanone 27-O-beta-D-glucoside => 27-hydroxywithanone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74271", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP = a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31494", "l": "soyasaponin III + UDP-beta-L-rhamnose <=> H(+) + soyasaponin I + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017797", "l": "NOTCH3 binds YBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607002", "l": "Activated protein C cleaves factor VIIIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72931", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] = atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13598", "l": "1,4-diguanidinobutane + H2O => agmatine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44592", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27331", "l": "5-hydroxyisourate + H2O + NAD(+) => H(+) + NADH + O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769042", "l": "NPAS4 stimulates IQSEC3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54428", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57211", "l": "glyoxal + L-cysteinyl-[protein] <=> S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30573", "l": "6 AMP + 6 diphosphate + enterobactin + 4 H(+) => 3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16909", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O = 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.2.1", "l": "\"glycine dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19103", "l": "4-hydroxy-2-butynal + H(+) + NADH => 2-butyne-1,4-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45007", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA <=> CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36420", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60860", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66681", "l": "ATP + coproporphyrinogen III(in) + H2O => ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53659", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21481", "l": "2-furoyl-CoA + A + H2O => 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50110", "l": "CoA + H(+) + N-hexadecanoyl-taurine => hexadecanoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27941", "l": "(3R)-3-hydroxy-D-aspartate <=> glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701537", "l": "p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52972", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12663", "l": "CoA + O-hexadecanoyl-(R)-carnitine => (R)-carnitine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15544", "l": "DIMBOA + UDP-alpha-D-glucose <=> DIMBOA beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10138", "l": "2-hydroxy-3-oxopropanoate + CO2 => 2 glyoxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201608", "l": "Caspase-mediated cleavage of alpha adducin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62398", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2S)-pseudoephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60752", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone = CoA + jasmolin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046980", "l": "tapasin binding", "d": ["Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706393", "l": "RHOBTB3 binds ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194818", "l": "botA LC cleaves target cell SNAP25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61781", "l": "keto-L-tagatose => keto-L-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31918", "l": "ATP + D-maltose <=> ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102386", "l": "phenylacetaldehyde reductase activity", "d": ["Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55490", "l": "ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8957241", "l": "TP73 tetramer translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110322", "l": "Formation of Pol zeta complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029268", "l": "Phosphorylation and activation of PLCG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64750", "l": "2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate => H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18776", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] <=> Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8960973", "l": "RLBP1:11cRAL dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72621", "l": "Ribosomal scanning  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30969", "l": "9,9'-di-cis-zeta-carotene => 9,9',15-tri-cis-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56768", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 = 2 A + all-trans-adonixanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31868", "l": "(S)-2,3-epoxysqualene => baccharis oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40796", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14763", "l": "3-oxosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73957", "l": "4-ethylcatechol + NAD(+) => 3,4-dihydroxystyrene + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669023", "l": "TWEAK binds FN14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11861", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682377", "l": "LC3 de-lipidation by ATG4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114553", "l": "Activation of conventional Protein Kinase C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16163", "l": "2 Fe(II)-[leghemoglobin] + H(+) + NAD(+) => 2 Fe(III)-[leghemoglobin] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3786258", "l": "TP53 binds the CDKN1A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688786", "l": "ATXN3 binds RAD23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58134", "l": "AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine => A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35795", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine = H(+) + kanamycin A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40519", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13444", "l": "H2O + L-cysteate <=> H(+) + NH4(+) + pyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349455", "l": "Phosphorylation of MDM4 by ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57435", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] <=> 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29999", "l": "ATP + H2O + spermidine(out) = ADP + H(+) + phosphate + spermidine(in)", "d": [], "t": []}, {"i": "EC:7.6.2.11", "l": "\"ABC-type polyamine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034320", "l": "alcohol O-hexanoyltransferase activity", "d": ["Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34636", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + pentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57314", "l": "cytidine 5'-diphosphoramidate + H(+) + L-glutamate => H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35708", "l": "(2S)-versicolorone + H(+) + NADPH + O2 => (3S)-versiconol acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52814", "l": "(9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106226", "l": "peptide 2-hydroxyisobutyryltransferase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide."], "t": []}, {"i": "RHEA:24180", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350158", "l": "LGMN degrades GC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32361", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+) => 1D-myo-inositol 1,4,5-trisphosphate + 2 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34278", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.2", "l": "\"chymotrypsin C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24972", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45380", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18008", "l": "D-threitol + NADP(+) <=> D-erythrulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64169", "l": "2-ethyl-L-serine => (2S)-2-aminobutanoate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047239", "l": "hydroxymandelonitrile glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H+ + taxiphyllin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611839", "l": "β3-agonists bind ADRB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48156", "l": "a ganglioside GQ1b (d18:1(4E)) + H2O = a ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14297", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose", "d": [], "t": []}, {"i": "EC:3.2.1.46", "l": "\"galactosylceramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34670", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140750", "l": "nucleosome array spacer activity", "d": ["A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48216", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64894", "l": "AMP + H(+) + tetradecanoyl-[ACP] => holo-[ACP] + tetradecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944255", "l": "Association of procollagen type VII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63236", "l": "ATP + streptomycin = 6-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47937", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65045", "l": "4-cyanobenzyl alcohol + NAD(+) => 4-cyanobenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64950", "l": "dCDP + H(+) + phosphate => dCTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58951", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102677", "l": "campesterol,NADPH:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + campesterol + O2 + NADPH = (22S)-22-hydroxycampesterol + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25867", "l": "H2O + N(1)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24159", "l": "2-methylpropanoate + ATP <=> 2-methylpropanoyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004018", "l": "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity", "d": ["Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75965", "l": "15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione => 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47311", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68333", "l": "(R)-4'-phosphopantothenate + H2O => (R)-pantothenate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374896", "l": "Uptake of Noradrenaline (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45115", "l": "gamma-tocopherol + H(+) + NADPH + O2 <=> 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57861", "l": "(E)-6-hydroxyferuloyl-CoA => CoA + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43762", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12] => acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22221", "l": "ent-copalyl diphosphate => diphosphate + ent-kaur-16-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.42", "l": "\"branched-chain-amino-acid transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045134", "l": "UDP phosphatase activity", "d": ["Catalysis of the reaction: UDP + H2O = UMP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449978", "l": "IL7 binds IL7R:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50532", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0120284", "l": "tryptophan binding", "d": ["Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10542", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde => 7,8-dihydroneopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098622", "l": "selenodiglutathione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: H+ + selenodiglutathione + NADPH = gluthathioselenol + glutathione + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11118", "l": "an N-acetylalkane-alpha,omega-diamine + CoA + H(+) => acetyl-CoA + an alkane-alpha,omega-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606883", "l": "CD19 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938815", "l": "RNF152 polyubiquitinates RRAGA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39556", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23924", "l": "pppGp(2'-5')A = 2',3'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56499", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420977", "l": "Ca permeable AMPA receptor ligand binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55601", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70358", "l": "1-carboxybiuret + H(+) <=> biuret + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012082", "l": "Autocatalytic phosphorylation of FGFR3 cysteine mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74534", "l": "AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0042389", "l": "omega-3 fatty acid desaturase activity", "d": ["Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759176", "l": "NFE2L2-dependent HMOX1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203130", "l": "OLR1 binds to oxidized LDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42226", "l": "AH2 + androst-4-ene-3,17-dione => A + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848774", "l": "PTK6 binds DOK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043958", "l": "acryloyl-CoA reductase (NADH) activity", "d": ["Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10489", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP => (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198508", "l": "MDH1 oxidizes MAL to OA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617864", "l": "HOXD4 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46236", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20930", "l": "[DsbA protein]-disulfide + a quinol => [DsbA protein]-dithiol + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691363", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811479", "l": "ING2 recruits EP300 to TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31270", "l": "6-hydroxyhexanoate + NADP(+) <=> 6-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73687", "l": "dAMP(out) + phosphate(in) = dAMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32555", "l": "(2E)-geranyl diphosphate + H2O = (R)-alpha-terpineol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.112", "l": "\"(+)-alpha-terpineol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390425", "l": "FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59322", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + H(+) => D-cellobiono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52660", "l": "an L-alpha-amino acid + ATP + holo-[ACP] = AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.n2", "l": "\"amino acid--[acyl-carrier-protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50522", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668714", "l": "RAC1:GTP binds NOX1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24317", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102261", "l": "8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity", "d": ["Catalysis of the reaction: NADP + a reduced coenzyme F420 = NADPH + H+ + an oxidized coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390909", "l": "HRH2 binds hist (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59284", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = D-glucose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35437", "l": "cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP => cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189062", "l": "lactose + H2O => D-glucose + D-galactose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34569", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-paratose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36297", "l": "D-maltose + phosphate => alpha-maltose 6'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29405", "l": "3-demethylubiquinol-8 + A + H2O => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35111", "l": "2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.346", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12460", "l": "(S)-malate = fumarate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.2", "l": "\"fumarate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200406", "l": "CPT1A,B transfers PALM to CAR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045133", "l": "2,3-dihydroxybenzoate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140660", "l": "cytoskeletal motor activator activity", "d": ["Binds to and increases the activity of a motor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60807", "l": "2-oxoglutarate + gibberellin A19 + O2 <=> CO2 + gibberellin A17 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37397", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791102", "l": "Expression of C19orf10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50662", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 3-(3-methylsulfanyl)propylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047332", "l": "diphosphate-serine phosphotransferase activity", "d": ["Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674019", "l": "BRAP binds KSR1:MARK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018754", "l": "GDIs bind RHOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77530", "l": "hexanal + hydrogen cyanide <=> (2S)-2-hydroxyheptanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69074", "l": "Formation of Processive Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57402", "l": "acetate + H(+) + narcotine hemiacetal => 3-O-acetylpapaveroxine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41368", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008160", "l": "protein tyrosine phosphatase activator activity", "d": ["Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004825", "l": "methionine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68982", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + tauroursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50664", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17096", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72103", "l": "Formation of pre-mRNPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8944457", "l": "MAF1 translocates to the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004069", "l": "L-aspartate:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35945", "l": "deoxybrevianamide E + diphosphate => brevianamide F + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016517", "l": "interleukin-12 receptor activity", "d": ["Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60176", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O = 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64566", "l": "ilicicolin H => 8-epi-ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102444", "l": "isorhamnetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine = 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60914", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58750", "l": "H(+) + nectriapyrone + S-adenosyl-L-homocysteine => desmethylnectriapyrone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19112", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose <=> 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613513", "l": "PLINs:HSPA8 binds PRKAA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71176", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) => 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71305", "l": "chloride(in) + L-methionine(in) + 2 Na(+)(in) => chloride(out) + L-methionine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73340", "l": "ATP + beta-alanine + H(+) => beta-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421831", "l": "trans-Golgi Network Coat Assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31491", "l": "soyasaponin III + UDP-beta-L-rhamnose = H(+) + soyasaponin I + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.273", "l": "\"soyasaponin III rhamnosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36709", "l": "O-ureido-D-serine => O-ureido-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23714", "l": "H(+) + NADPH + pregnan-21-al => NADP(+) + pregnan-21-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050042", "l": "lactate-malate transhydrogenase activity", "d": ["Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047538", "l": "2-carboxy-D-arabinitol-1-phosphatase activity", "d": ["Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47391", "l": "a tetradecanoate ester + H2O <=> an aliphatic alcohol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451283", "l": "kainate receptor binds glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805811", "l": "Release of SEPT4 from mitochondria (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698026", "l": "FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65758", "l": "(2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52104", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031687", "l": "A2A adenosine receptor binding", "d": ["Binding to an A2A adenosine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714481", "l": "RAC2 binds effectors at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66693", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] => dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332236", "l": "CBL neddylates TGFBR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19497", "l": "H(+) + L-aspartate = beta-alanine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.11", "l": "\"aspartate 1-decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73527", "l": "TDP(out) + UTP(in) = TDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43598", "l": "3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011543", "l": "DCA binds PDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10012", "l": "(R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.6", "l": "\"(R)-6-hydroxynicotine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534378", "l": "Hv1 Mediated H+ Permeability (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74454", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112396", "l": "Separation of elongating transcript from template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36712", "l": "ATP + H(+) + H2O + O-ureido-D-serine => ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67089", "l": "ATP + H2O + tetracosanoate(in) => ADP + H(+) + phosphate + tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58187", "l": "H(+) + NADPH + 2 phytyl diphosphate <=> (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60093", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64953", "l": "dCDP + H2O => dCMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449077", "l": "Interleukin-16 is secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72288", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) => 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418858", "l": "RhoGTPase GEF's recruited to DCC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210439", "l": "glutamate uptake by astrocytes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762345", "l": "PREDN:ALB dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50924", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75352", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine => 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73435", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34767", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228941", "l": "Transcytosis and dissociation of botE:NTNHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + verrucosan-2beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222399", "l": "Iron is reduced and separates from mycobactin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160003", "l": "mono-ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon mono-ADP-ribosylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814094", "l": "ARL1:GTP binds ARFIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76629", "l": "H(+) + hydrogencarbonate + NADH + propanoyl-CoA => (S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981728", "l": "Factor H binds to membrane-associated C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430183", "l": "NCK binds PAK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47286", "l": "6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68895", "l": "3-methoxybenzoate + ATP + H(+) + NADPH <=> 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66836", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] = asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0050998", "l": "nitric-oxide synthase binding", "d": ["Binding to nitric-oxide synthase."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41712", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56208", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9658253", "l": "RAS:GTP binds PI3K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19131", "l": "ADP + dTMP + H(+) => ATP + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791016", "l": "SFTPB binds itself (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55572", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine = 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187617", "l": "argininosuccinate <=> fumarate + arginine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448678", "l": "CTSG cleaves CASP1(1-404) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32098", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205244", "l": "Recruitment of CBL to KIT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24907", "l": "L-tyrosine => (E)-4-coumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634850", "l": "NPAS4 binds ARNT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62361", "l": "FMN-N(5)-peroxide + uracil => (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082356", "l": "HSF1-mediated gene expression (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32573", "l": "2-methylisoborneol + diphosphate => (E)-2-methylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11736", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.241", "l": "\"6-endo-hydroxycineole dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10469", "l": "D-xylulose 5-phosphate + phosphate => acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44976", "l": "(R)-carnitine + propanoyl-CoA = CoA + O-propanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77351", "l": "2-oxobutanoate + N(omega),N(omega)-dimethyl-L-arginine = (2S)-2-aminobutanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31314", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694583", "l": "ABHD4 hydrolyses NAPE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953339", "l": "DNPH1 hydrolyses dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14239", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine => 10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10453", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49482", "l": "H(+) + L-2-aminoadipate + NADPH => 2 H2O + L-1-piperideine-6-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16380", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75803", "l": "butanoate(out) + Na(+)(out) = butanoate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72631", "l": "Formation of the cap-binding eIF4F complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53439", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74086", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol <=> diphosphate + menaquinol-4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202721", "l": "JAM2 binds JAM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606564", "l": "GALC hydrolyzes GalCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004734", "l": "pyrimidodiazepine synthase activity", "d": ["Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41168", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33610", "l": "(9Z)-octadecenoate + ATP + CoA <=> (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34469", "l": "diphosphate + valerena-4,7(11)-diene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247511", "l": "STAB2:ligand is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34107", "l": "glycine + H(+) + hexadecanoyl-CoA = 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-555065", "l": "Formation of clathrin coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48728", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2301205", "l": "SETD8 monomethylates histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48644", "l": "prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55871", "l": "(S)-lactate + O2 <=> H2O2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19392", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30676", "l": "tetrahymanol => H2O + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033456", "l": "GCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42764", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.17.98.3", "l": "\"formate dehydrogenase (coenzyme F420)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45161", "l": "3-oxopropanoate + H(+) => acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718020", "l": "PTGFR binds PTGFR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50791", "l": "NADP(+) + pentan-2-one <=> (E)-pent-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72442", "l": "(E)-ferulate + ATP + H(+) <=> (E)-feruloyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53064", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62578", "l": "ADP + H(+) + L-cystine(in) + phosphate => ATP + H2O + L-cystine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64126", "l": "hexadecanoate + L-phenylalanine => H2O + N-hexadecanoyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23369", "l": "H(+) + phenylglyoxylate => benzaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54513", "l": "peregrinol diphosphate => (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63648", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63514", "l": "biphenyl-2,2',3-triol + H2O + NAD(+) => biphenyl-2,2'-diol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18585", "l": "D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.1", "l": "\"triose-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388808", "l": "CD28 homodimer binds B7-2 monomer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74362", "l": "coproporphyrin I(out) <=> coproporphyrin I(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77077", "l": "Capping complex formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74598", "l": "(2S,3R)-3-methyl-L-aspartate <=> mesaconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007447", "l": "E2F6 forms the PRC1L4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45214", "l": "CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein] => acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59076", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.361", "l": "\"GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45391", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32100", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside => DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45225", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648268", "l": "HTR1A binds HTR1A antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36983", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66577", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol => 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735789", "l": "Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14502", "l": "H2O + L-homocysteine => 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004152", "l": "dihydroorotate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.-", "l": "\"Exoribonucleases producing 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29564", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708275", "l": "PDE4A binds PDE4A inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57468", "l": "(E)-ferulate + UDP-alpha-D-glucose = 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857308", "l": "Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20362", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855232", "l": "RELN:VLDLR binds DAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32971", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10645", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42975", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a cardiolipin + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985943", "l": "p-Y701-STAT1 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68521", "l": "(2E,6E)-farnesyl diphosphate => beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74712", "l": "Dissociation of IRS-P from insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37814", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45490", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030160", "l": "synaptic receptor adaptor activity", "d": ["The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.49", "l": "\"O-acetylhomoserine aminocarboxypropyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58545", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75161", "l": "H(+) + NADP(+) + TDP => NAD(+) + TTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019151", "l": "galactose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70463", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43146", "l": "H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine => adenosine(22) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32366", "l": "L-gulono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237129", "l": "Acireductone is created (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682011", "l": "LC3 binds ATG7 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12880", "l": "acetylacetone + O2 <=> acetate + H(+) + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55548", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41460", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacylglycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25360", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.490486312819655", "identifiers": [{"i": "GO:0019901", "l": "protein kinase binding", "d": ["Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68327", "l": "1D-myo-inositol 2,5-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24567", "l": "a 3-oxo acid + succinyl-CoA <=> a 3-oxoacyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047665", "l": "aminolevulinate transaminase activity", "d": ["Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76031", "l": "2 H2O2 => O2 + 2 H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44066", "l": "CoA + octyl hexadecanoyl => hexadecanoyl-CoA + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626938", "l": "Beta-catenin binds SOX proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005056", "l": "tiggrin receptor activity", "d": ["Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34305", "l": "L-pipecolate + NH4(+) => L-lysine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17106", "l": "malonyl-[ACP] + S-adenosyl-L-methionine => malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0160002", "l": "ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon ADP-ribosylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681987", "l": "LC3 is cleaved by ATG4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26187", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109857", "l": "MAP2K1 binds MAPK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35350", "l": "3-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76165", "l": "18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin] => 11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66463", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> 14betaH-scalarane-17alpha-19-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33103", "l": "(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.125", "l": "\"alpha-muurolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40232", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14038", "l": "4,5beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604360", "l": "Initial activation of proMMP2 by MMP14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694527", "l": "Loss of SAR1B GTPase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27662", "l": "(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641205", "l": "RSPO:LGR binds ZNRF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45345", "l": "a globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a globoside NORint (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678843", "l": "ISGylation of protein translation regulator 4EHP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37649", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11767", "l": "H2O + methylguanidine <=> methylamine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451377", "l": "Interaction of IQGAP1 with nephrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534378", "l": "Hv1 Mediated H+ Permeability (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130731", "l": "Formation of COPII vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679775", "l": "COMT binds COMT Inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11774", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21242", "l": "diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] => geranylgeranyl diphosphate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62287", "l": "2 ATP + L-proline + L-tryptophan + NADPH <=> (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656891", "l": "OPN1SW binds 11cRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16479", "l": "15-oxoprostaglandin E1 + H(+) + NADH => NAD(+) + prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26525", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-trans-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53116", "l": "an 11beta-hydroxysteroid + NAD(+) = an 11-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807585", "l": "BPI binds LPS on the bacterial surface (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944225", "l": "Association of procollagen type XVII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44713", "l": "a 1,2-diacylglycerol + H2O => a 1-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253325", "l": "ERBB4s80 binds TAB2:NCOR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013024", "l": "RHOB binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18664", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) <=> H(+) + L-ornithine + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55880", "l": "apo-[aequorin]--coelenterazine + O2 = [aequorin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44816", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71795", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34932", "l": "glutathioselenol + NADPH => glutathione + hydrogenselenide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68754", "l": "alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11577", "l": "ATP + thiamine => AMP + H(+) + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12737", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": [], "t": []}, {"i": "EC:1.21.4.1", "l": "\"D-proline reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57368", "l": "H2O + NADPH = (6R)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47915", "l": "6-deoxy-6-sulfo-D-gluconate <=> 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36571", "l": "sphinganine + tetradecanoyl-CoA = CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21276", "l": "D-arabinitol + NADP(+) = D-xylulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33159", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.54", "l": "\"N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18827", "l": "[(1->6)-alpha-D-glucosyl](n+1) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033787", "l": "cyanocobalamin reductase (cyanide-eliminating) activity", "d": ["Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP+ = cyanocob(III)alamin + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26364", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614461", "l": "Tetramerization of procollagen VI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789615", "l": "Expression of STAT3-upregulated extracellular proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160080", "l": "ABC-type indole transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + indole(in) = ADP + phosphate + indole(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13789", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63950", "l": "phosphate + sphinga-4E,14Z-dienine => H2O + sphinga-4E,14Z-dienine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694462", "l": "ABHD6,12 hydrolyse 3AG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76874", "l": "(S)-1-phenylethylamine + H2O + NAD(+) <=> acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65818", "l": "A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71793", "l": "(R)-lactate(out) + H(+)(out) => (R)-lactate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75244", "l": "FASL binds FAS Receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981892", "l": "Active G alpha (z) binds RGS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62384", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.61", "l": "\"cyclic 2,3-diphosphoglycerate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804955", "l": "ATM phosphorylates MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:0051139", "l": "metal cation:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)."], "t": []}, {"i": "REACT:R-HSA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54822", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332359", "l": "Active calmodulin binds CAMK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003833", "l": "beta-alanyl amine synthase activity", "d": ["Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70902", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35270", "l": "ethanol(in) <=> ethanol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30679", "l": "D-cellobiose + H2O = beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55001", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005166", "l": "neurotrophin p75 receptor binding", "d": ["Binding to a neurotrophin p75 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805785", "l": "AKT phosphorylates PHF20 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53640", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.162", "l": "\"(-)-alpha-amorphene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0061595", "l": "6-deoxy-6-sulfofructose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68603", "l": "ORC5 binds ORC2:ORC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76795", "l": "2-aminopropan-1-ol + H2O + NAD(+) = H(+) + hydroxyacetone + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14131", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66382", "l": "ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycodeoxycholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678843", "l": "ISGylation of protein translation regulator 4EHP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782264", "l": "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68166", "l": "H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30070", "l": "betaine aldehyde + H2O + NADP(+) <=> glycine betaine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54653", "l": "peregrinol diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30599", "l": "15-cis-phytoene + 3 A = 3 AH2 + all-trans-neurosporene", "d": [], "t": []}, {"i": "EC:1.3.99.28", "l": "\"phytoene desaturase (neurosporene-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420131", "l": "The PACAP receptor binds PACAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388828", "l": "PD-1 binds B7DC and B7H1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50625", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O => a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15242", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54029", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928578", "l": "EPH receptors autophosphorylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40803", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42297", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018798", "l": "RHOV binds GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70247", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821486", "l": "HCFC1 binds SET1A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37789", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72412", "l": "inulobiose => alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020513", "l": "GRIN2B gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15993", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036202", "l": "ent-cassa-12,15-diene 11-hydroxylase activity", "d": ["Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9736953", "l": "FURIN translocates to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39793", "l": "20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613497", "l": "Unwinding DNA for the nascent transcript (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18665", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) = (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": [], "t": []}, {"i": "EC:2.7.4.17", "l": "\"3-phosphoglyceroyl-phosphate--polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211924", "l": "CYP4B1 12-hydroxylates ARA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36099", "l": "benzoate + S-adenosyl-L-methionine = methyl benzoate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.273", "l": "\"benzoate O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212642", "l": "L-Glutamine transport into neurons (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29724", "l": "glyoxylate(in) => glyoxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690023", "l": "NUBPL binds 4Fe-4S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672969", "l": "Phosphorylation of RAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615910", "l": "SUMOylation of PCNA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24295", "l": "acetyl-CoA + L-glutamate <=> CoA + H(+) + N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30798", "l": "2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24965", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034864", "l": "2,4,4-trimethylpentanal dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686625", "l": "LAIR1 binds collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.17.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37126", "l": "sphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44155", "l": "1D-myo-inositol 2-phosphate + H2O <=> myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74942", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 <=> a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12988", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051507", "l": "beta-sitosterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39209", "l": "(3R)-hydroxyhexacosanoyl-CoA + NADP(+) => 3-oxohexacosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008997", "l": "ribonuclease R activity", "d": ["Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.-", "l": "\"Phosphoric diester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0050486", "l": "intramolecular hydroxytransferase activity", "d": ["Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule."], "t": []}, {"i": "EC:5.4.4.-", "l": "\"Transferring hydroxy groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38281", "l": "(3R)-citramalyl-CoA + succinate => (3R)-citramalate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70244", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757954", "l": "N4BP1 binds IKBKG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34661", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34542", "l": "S-adenosyl-L-methionine + tellurite <=> methanetellurite + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56154", "l": "(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12589", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34604", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47556", "l": "H2O + taurodeoxycholate = deoxycholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39441", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10950", "l": "ADP + D-glucosamine 6-phosphate + H(+) => ATP + D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647978", "l": "pro-RAS proteins are farnesylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28082", "l": "(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.85", "l": "\"crotonyl-CoA carboxylase/reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33376", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH => a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41664", "l": "dihydrochelirubine + NAD(+) = chelirubine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13635", "l": "ADP + gamma-L-glutamylputrescine + H(+) + phosphate => ATP + L-glutamate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60928", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27924", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199298", "l": "AKT phosphorylates CREB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197963", "l": "DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38259", "l": "(2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76270", "l": "carnosine(in) <=> carnosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928617", "l": "EPHB2 binds KALRN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71845", "l": "tauroursodeoxycholate(in) => tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10791", "l": "2-dehydro-D-gluconate + ATP <=> 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13833", "l": "L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.84", "l": "\"arginine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369052", "l": "ABCAs mediate lipid influx (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19299", "l": "ADP + carnosine + H(+) + phosphate => ATP + beta-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15287", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate => AMP + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.18", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29232", "l": "cyanate(in) => cyanate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.134", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.20", "l": "\"phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46565", "l": "acetyl-CoA + apo-[ACP] => acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051864", "l": "histone H3K36 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9710959", "l": "p-STAT1 dimer binds KPNA1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75212", "l": "Cu(+)(out) => Cu(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140682", "l": "FAD-dependent H3K4me/H3K4me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11105", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine => H(+) + hercynine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65567", "l": "(9Z)-octadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772430", "l": "CTNNBIP1 binds beta-catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181156", "l": "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36686", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27746", "l": "H(+) + L-cysteine = CO2 + cysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72809", "l": "L-histidine(in) => L-histidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60200", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.66", "l": "\"[histone H3]-trimethyl-L-lysine(9) demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40670", "l": "2-aminoprop-2-enoate <=> 2-iminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22971", "l": "butanal + CoA + NAD(+) <=> butanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47331", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63170", "l": "S-(2-succino)-L-cysteine => fumarate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69128", "l": "glyoxylate + L-leucine = 4-methyl-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218806", "l": "FYN autophosphorylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72702", "l": "acrylate + H(+) + NADH <=> NAD(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.540281582338167", "identifiers": [{"i": "GO:0005372", "l": "water transmembrane transporter activity", "d": ["Enables the transfer of water (H2O) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69294", "l": "goitrin + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034450", "l": "ubiquitin-ubiquitin ligase activity", "d": ["Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32176", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25871", "l": "H2O + N(1),N(12)-diacetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19866", "l": "4 H(+) + uroporphyrinogen III => 4 CO2 + coproporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071987", "l": "WD40-repeat domain binding", "d": ["Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53340", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396029", "l": "Latent TGF-beta-3 binds integrins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40696", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol => 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61125", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37409", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607751", "l": "TRAF6 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70627", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49835", "l": "a fatty aldehyde + H2O + NAD(+) <=> a fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36283", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 = 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052737", "l": "pyruvate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47612", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.337", "l": "\"1,2-diacylglycerol 3-alpha-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805109", "l": "CDK2 phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008798", "l": "beta-aspartyl-peptidase activity", "d": ["Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34875", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50346", "l": "3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+) => 3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050242", "l": "pyruvate, phosphate dikinase activity", "d": ["Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H+ + phosphoenolpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52633", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30033", "l": "cis,cis-muconate + H(+) => (S)-muconolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33873", "l": "glyoxylate + NH4(+) + urea => (S)-2-ureidoglycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24156", "l": "2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.2.14", "l": "\"branched-chain-fatty-acid kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31372", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine => (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71898", "l": "dGTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46220", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9675026", "l": "Formation of the MLL1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451418", "l": "Pellino ubiquitinates IRAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31370", "l": "2 H(+) + 3 nitrite <=> H2O + nitrate + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29445", "l": "H(+)(out) + L-alanine(out) => H(+)(in) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50147", "l": "ethyl (9Z)-hexadecenoate + H2O <=> (9Z)-hexadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.203", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102298", "l": "selenocystathione synthase activity", "d": ["Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35297", "l": "AMP + H2O + W-molybdopterin cofactor => adenylyl-molybdopterin + H(+) + tungstate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39167", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13878", "l": "a 2-oxocarboxylate + L-ornithine => an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.774074961591239", "identifiers": [{"i": "GO:0008234", "l": "cysteine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58685", "l": "FAD + 2 H(+) + NADPH + O2 => FADH2-C4alpha-hydroperoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52839", "l": "H(+) + indole + NADH + O2 <=> H2O + indoxyl + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45757", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28472", "l": "pyridoxine(out) => pyridoxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51064", "l": "3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32781", "l": "ADP + Co(2+)(in) + H(+) + phosphate => ATP + Co(2+)(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49467", "l": "2,6-dihydroxybenzoate + H(+) <=> CO2 + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950387", "l": "CANX binds EBI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000827", "l": "inositol-1,3,4,5,6-pentakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32776", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O => (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58780", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine = a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31793", "l": "(13S)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.13", "l": "\"glutathione gamma-glutamate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53221", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218814", "l": "PAK2 autophorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58446", "l": "H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450422", "l": "KSRP recruits RNA degradation activities (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44743", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine <=> H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36119", "l": "gibberellin A9 + S-adenosyl-L-methionine = O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73667", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine = (E,E)-piperlonguminine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10575", "l": "vinylacetyl-CoA <=> (2E)-butenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047873", "l": "dolichyl-phosphatase activity", "d": ["Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696267", "l": "RND3 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106388", "l": "18S rRNA aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine."], "t": []}, {"i": "RHEA:63296", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005499", "l": "vitamin D binding", "d": ["Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605313", "l": "Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873926", "l": "IFNG dimer binds IFNGR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76139", "l": "D-gluconate(in) = D-gluconate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3134954", "l": "DHX9 binds DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77596", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22325", "l": "H2O + leukotriene A4 => leukotriene B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56599", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 <=> (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40669", "l": "2-iminopropanoate => 2-aminoprop-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39659", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61460", "l": "a cytidine in RNA + S-adenosyl-L-methionine = a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57578", "l": "H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27847", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47641", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.25", "l": "\"inositol-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649856", "l": "Oxidative damage to the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36493", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160931", "l": "Disassembly of tight junctions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002460", "l": "P4HB binds Collagen chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46316", "l": "GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44751", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50303", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12177", "l": "phenylethanolamine + S-adenosyl-L-methionine => H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56059", "l": "genistein + UDP-alpha-D-glucose <=> genistein 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57426", "l": "catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaiacol + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28509", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP <=> 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56720", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134962", "l": "DHX36 binds DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64087", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) <=> 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73501", "l": "4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',7-trihydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43213", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500717", "l": "Activation of GRIK3 homomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0031834", "l": "neurokinin receptor binding", "d": ["Binding to a neurokinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29191", "l": "L-aspartate + menaquinone-8 = iminosuccinate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202692", "l": "PIP3 binds to RhoA and activates it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19180", "l": "L-lysine <=> (3S)-3,6-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11567", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate <=> alpha-D-glucose 1-phosphate + D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76416", "l": "3',3'-cGAMP(out) + n H(+)(out) => 3',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1008200", "l": "NFE2 binds the beta globin locus control region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62861", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53219", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23640", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": [], "t": []}, {"i": "EC:1.14.17.4", "l": "\"aminocyclopropanecarboxylate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48657", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15475", "l": "flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP => flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66392", "l": "ATP + H2O + prostaglandin E1(in) = ADP + H(+) + phosphate + prostaglandin E1(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27272", "l": "H(+) + hexadecanoyl-CoA + NADPH => CoA + hexadecanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77384", "l": "H(+) + hnu + octanoate => CO2 + heptane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12077", "l": "an aromatic primary alcohol + NAD(+) => an aromatic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40117", "l": "CoA + H(+) + hexanoate => H2O + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879910", "l": "JAK2 is phosphorylated, activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44012", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615910", "l": "SUMOylation of PCNA with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700181", "l": "Autophosphorylation of ALK fusions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73345", "l": "AMP + beta-alanyl-[peptidyl-carrier protein] + H(+) => beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42169", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27479", "l": "CO2 + formaldehyde + neopinone + succinate => 2-oxoglutarate + O2 + thebaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46988", "l": "(R)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65415", "l": "dAMP(in) + NAD(+)(out) <=> dAMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814094", "l": "ARL1:GTP binds ARFIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64814", "l": "CoA + H(+) + S-(2-acetamidoethyl)-homocysteine => acetyl-CoA + S-(2-aminoethyl)-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74852", "l": "acetaldehyde + dopamine => (R)-salsolinol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24066", "l": "H(+) + 2 H2O + porphobilinogen => 2 5-aminolevulinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47848", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450975", "l": "isocitrate <=> citrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46068", "l": "(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38858", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.50", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44375", "l": "Cr(6+) + 2 NADH + O2 <=> Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25595", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 => 2-oxoglutarate + H(+) + isochorismate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39819", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60462", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008902", "l": "hydroxymethylpyrimidine kinase activity", "d": ["Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37327", "l": "ATP + H2O + L-methionyl-L-alanine(out) = ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69645", "l": "(2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36548", "l": "octadecanoyl-CoA + sphinganine => CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37459", "l": "1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47279", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43835", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660660", "l": "p300 acetylates RELA subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61906", "l": "H2O + NADP(+) + stemphyloxin II => betaenone A + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63730", "l": "candesartan-2-N-beta-D-glucuronide + UDP => candesartan + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375140", "l": "CDO binds promyogenic cadherins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17751", "l": "AH2 + quinolin-2(1H)-one => A + H2O + quinoline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213208", "l": "Type X collagen associates with collagen type II fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65409", "l": "NAD(+)(in) => NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46159", "l": "15,9'-di-cis-phytofluene + a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21069", "l": "A + H2O + nitrite => AH2 + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24634", "l": "5 H(+) + 3 NADPH + nitrite => 2 H2O + 3 NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761027", "l": "ZEB2 binds SP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12452", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.134", "l": "\"inositol-tetrakisphosphate 1-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419426", "l": "Cannabinoid receptors can bind cannabinoids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685604", "l": "SLAMF6 binds SLAMF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53303", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O <=> H(+) + N-carbamoyl-D-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30325", "l": "beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45535", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34225", "l": "2,6-dihydroxypseudooxynicotine + AH2 => 6-hydroxypseudooxynicotine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13463", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+) => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983156", "l": "Polyubiquitination of substrate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42944", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39433", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76604", "l": "(12Z)-10-hydroxyoctadecenoate + H2O => 10,13-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56130", "l": "AH2 + diphosphate + flavuxanthin => A + dimethylallyl diphosphate + H2O + nonaflavuxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008696", "l": "4-amino-4-deoxychorismate lyase activity", "d": ["Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465924", "l": "OPN1LW binds 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25430", "l": "ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate => ATP + N-acetyl-D-hexosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426032", "l": "DAG is metabolized by DAGL to 2-AG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823849", "l": "Expression of GATA4 in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21530", "l": "[phosphate](n-1) + H(+) + phosphate => [phosphate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174445", "l": "RPA binds to the Flap on the C-strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693478", "l": "HTR1A binds HTR1A agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015478", "l": "oligosaccharide transporting porin activity", "d": ["Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033966", "l": "N-substituted formamide deformylase activity", "d": ["Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76058", "l": "norreticuline + S-adenosyl-L-methionine <=> H(+) + reticuline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69231", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate <=> an epithionitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70074", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol <=> (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177920", "l": "Binding of GRB2 to GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005137", "l": "interleukin-5 receptor binding", "d": ["Binding to an interleukin-5 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46129", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164840", "l": "ADP and Pi bind to ATPase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681674", "l": "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45317", "l": "H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75445", "l": "heme b(out) => heme b(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176417", "l": "SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73576", "l": "(E,E)-piperate + ATP + H(+) => (E,E)-piperoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27973", "l": "D-maltotriose + H2O <=> alpha-D-glucose + D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32978", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35936", "l": "2 ATP + L-proline + L-tryptophan => 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45192", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65063", "l": "NADP(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351208", "l": "Spermidine  => N-acetylated spermidine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047842", "l": "dehydro-L-gulonate decarboxylase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate + H+ = L-xylulose + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39562", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14918", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32708", "l": "(2E)-geranyl diphosphate => (2R,4S)-bornyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9669854", "l": "KIT binds type II TKIs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41342", "l": "10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106330", "l": "sialate 9-O-acetylesterase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate."], "t": []}, {"i": "RHEA:22600", "l": "H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983150", "l": "Proteasomal cleavage of substrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688377", "l": "Defective pro-SFTPC does not translocate from ER membrane to multivesicle body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250947", "l": "B-WICH complex binds rDNA promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368119", "l": "Expression of CLOCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60409", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682598", "l": "ATM phosphorylates HERC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15919", "l": "aldono-1,5-lactone + H(+) + NADH => an aldopyranose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56256", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62237", "l": "a cytidine(6-4)cytidine in DNA => a cytidine dimer in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.4", "l": "\"malate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033777", "l": "lithocholate 6beta-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + lithocholate + NADPH + O2 = 6-beta-hydroxylithocholate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39849", "l": "a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+) => a 2-acylglycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55431", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54977", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O => (3S)-hydroxytetradecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340587", "l": "RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417842", "l": "P2Y10 receptor can bind to LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38986", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48096", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.319", "l": "\"type I protein arginine methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46905", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32105", "l": "2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + trans-resveratrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62908", "l": "nor-toralactone + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20430", "l": "apigenin + S-adenosyl-L-methionine => acacetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77500", "l": "2-phenylacetaldehyde + hydrogen cyanide => (2S)-2-hydroxy-3-phenylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676255", "l": "Formation of the MLL2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045438", "l": "delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity", "d": ["Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110322", "l": "Formation of Pol zeta complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102152", "l": "Delta12-linoleate epoxygenase activity", "d": ["Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 = 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43519", "l": "2-carboxy-5-formylfuran + H2O <=> 2-carboxy-5-(dihydroxymethyl)furan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76886", "l": "3-aminobutan-1-ol + H2O + NAD(+) <=> 4-hydroxybutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37373", "l": "a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938853", "l": "CDK6 binds RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17468", "l": "H2O + quercitrin <=> L-rhamnopyranose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034876", "l": "isonicotinic acid hydrazide hydrolase activity", "d": ["Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383190", "l": "HCO3- transport through ion channel (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59087", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66956", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.378", "l": "\"GDP-mannose:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,4-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29610", "l": "H2O + NAD(+) + nitrous oxide <=> H(+) + NADH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57600", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167408", "l": "The high affinity receptor complex binds to G-protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32099", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside = DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.241", "l": "\"2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015471", "l": "nucleoside-specific channel forming porin activity", "d": ["Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43863", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25359", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.6", "l": "\"phycoerythrobilin synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71983", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050371", "l": "tyrosine phenol-lyase activity", "d": ["Catalysis of the reaction: L-tyrosine + H2O = NH4 + phenol + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68187", "l": "a medium-chain fatty acyl-CoA + H2O <=> a medium chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043728", "l": "2-keto-4-methylthiobutyrate aminotransferase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140486", "l": "zinc ion sequestering activity", "d": ["Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990272", "l": "anti-Mullerian hormone receptor activity", "d": ["Combining with anti-Mullerian hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58940", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH = all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73413", "l": "succinate(out) + sulfate(in) => succinate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55146", "l": "[4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH => [(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832037", "l": "P binds to PPP1C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67623", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112690", "l": "PTPN11 binds CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71694", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) <=> glycyl-L-glutamate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47573", "l": "a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42186", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3beta,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16288", "l": "D-octopine + H2O + NAD(+) <=> H(+) + L-arginine + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73312", "l": "L-thyroxine sulfate(out) => L-thyroxine sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62562", "l": "(4R)-perillyl alcohol + AH2 => (4R)-limonene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693536", "l": "ATM phosphorylates MDC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62106", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353455", "l": "Autophosphorylation of DNA-PKcs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69121", "l": "glyoxylate + L-phenylalanine => 3-phenylpyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64860", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine = (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120053", "l": "ribitol beta-1,4-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.28", "l": "\"bacillolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19349", "l": "(R)-4-dehydropantoate + H2O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.33", "l": "\"(R)-dehydropantoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177920", "l": "Binding of GRB2 to GAB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40562", "l": "dTDP-beta-L-evernosamine + NADPH + O2 <=> dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52031", "l": "a jasmonyl-L-amino acid + H2O <=> a jasmonate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71893", "l": "H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide => dGMP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004862", "l": "cAMP-dependent protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase."], "t": []}, {"i": "REACT:R-HSA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38377", "l": "bisanhydrobacterioruberin + 2 H2O => bacterioruberin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59810", "l": "D-tyrosine => L-tyrosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22204", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855047", "l": "Hydrolysis of internal thioester in C4b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56062", "l": "CO2 + pentadecane => H(+) + hexadecanoate + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72421", "l": "(E)-4-coumaroyl-AMP + diphosphate => (E)-4-coumarate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50558", "l": "H2O + prostaglandin J2 => prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950398", "l": "CANX dissociates from IL27:EBI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76335", "l": "L-aspartate(in) + L-tryptophan(out) = L-aspartate(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74576", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418456", "l": "cGMP is degraded by PDEs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205649", "l": "p62 links damaged mitochondria to LC3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23043", "l": "2-oxobutanoate + acetyl-CoA + H2O <=> (R)-2-ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11504", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": [], "t": []}, {"i": "EC:2.1.1.109", "l": "\"demethylsterigmatocystin 6-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31188", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204311", "l": "AOX1 oxidises PXL to PDXate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377640", "l": "Autophosphorylation of SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592233", "l": "p38 MAPK phosphorylates PPARGC1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27703", "l": "aldehydo-D-galacturonate => keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445089", "l": "Dephosphorylation of pL1 (Y1176) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67069", "l": "AH2 + chermesin D methyl ester => A + asnovolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58499", "l": "choline + H(+) + NADH + O2 <=> glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63161", "l": "H2O + N-(15Z-tetracosenoyl)-taurine => (15Z)-tetracosenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21119", "l": "D-maltose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64646", "l": "butyl propanoate + CoA => butan-1-ol + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9734730", "l": "ORC1 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31353", "l": "(S)-2,3-epoxysqualene + H2O => lupan-3beta,20-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61187", "l": "quercitrin + UDP-beta-L-rhamnose <=> H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18383", "l": "dihydroxyacetone phosphate + pyruvate => dihydroxyacetone + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29796", "l": "ATP(in) + H2O(in) + Zn(2+)(out) => ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.263", "l": "\"abscisate beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733969", "l": "Bile salts dissociate from FABP6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22629", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611721", "l": "β1-agonists bind ADRB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433506", "l": "Phosphorylation of APS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030777", "l": "(S)-scoulerine 9-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381283", "l": "Expression of PPARG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68531", "l": "(2E,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0008172", "l": "S-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule."], "t": []}, {"i": "REACT:R-HSA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707505", "l": "Hemes bind to CLEC1B dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68196", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA = 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10881", "l": "7-methylxanthosine + H2O => 7-methylxanthine + D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10194", "l": "ADP + H(+) + phosphate + sulfate(in) => ATP + H2O + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15668", "l": "aldehydo-D-glucose + L-lysyl-[protein] <=> H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9844955", "l": "CLN3 transports GalCer to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68782", "l": "alpha-humulene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21295", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74821", "l": "glutathione(out) => glutathione(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22836", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.41", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24698", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70625", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38606", "l": "NADP(+) <=> 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249378", "l": "STING recruits TBK1 and STAT6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39156", "l": "(3R)-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11100", "l": "4-hydroxyhexan-3-one = 2 propanal", "d": [], "t": []}, {"i": "EC:4.1.2.35", "l": "\"propioin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73221", "l": "L-xylopyranose(in) + 2 Na(+)(in) => L-xylopyranose(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106282", "l": "isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD+ = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H+ + NADH."], "t": []}, {"i": "RHEA:42024", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51933", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite => 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008200", "l": "NFE2 binds the beta globin locus control region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55876", "l": "apo-[aequorin] + coelenterazine = apo-[aequorin]--coelenterazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681169", "l": "CRBN binds IMiDs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60934", "l": "17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48749", "l": "D-threitol + NAD(+) => D-erythrulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047456", "l": "2-methylisocitrate dehydratase activity", "d": ["Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37734", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593672", "l": "Myosin-X binds DCC/Neogenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990655", "l": "4 iron, 3 sulfur cluster binding", "d": ["Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24185", "l": "4,5-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798299", "l": "TP53 stimulates E2F7 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013158", "l": "CDC42 GDIs block activation of CDC42 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102351", "l": "gamma-aminobutyrate transaminase (glyoxylate dependent) activity", "d": ["Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68082", "l": "a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418863", "l": "Shp2 binds pUnc5C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14176", "l": "dimethylallyl diphosphate + L-tryptophan <=> 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031610", "l": "p-S133 CREB1, MEF2D and SRF  bind the ARC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17362", "l": "3-oxo-3-ureidopropanoate + H2O => H(+) + malonate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45641", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37440", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57716", "l": "hydrogencarbonate + NH4(+) = carbamate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191763", "l": "snRNP:Snurportin complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202472", "l": "Translocation of TRAF6 to CBM complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110311", "l": "POLZ extends translesion synthesis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54088", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016087", "l": "ecdysiostatic hormone activity", "d": ["The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004314", "l": "[acyl-carrier-protein] S-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654569", "l": "Activated FGFR1 binds FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70571", "l": "D-glucose(out) + Na(+)(out) = D-glucose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612243", "l": "APOE gene transcription is stimulated by ERBB4s80 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52319", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35716", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O => (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014296", "l": "RAC2 GEFs activate RAC2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680248", "l": "Phosphorylation of extracellular domain KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174157", "l": "Degradation of multiubiquitinated Cyclin B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57955", "l": "H(+) + NADH + O2 + phenol <=> catechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49180", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine = a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.333", "l": "\"bacteriochlorophyllide d C-20 methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32203", "l": "(R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine", "d": [], "t": []}, {"i": "EC:4.2.1.88", "l": "\"synephrine dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011598", "l": "DOCKs bind to RhoGEFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299359", "l": "Activation of TALK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0035033", "l": "histone deacetylase regulator activity", "d": ["Binds to and modulates the activity of histone deacetylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51215", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41629", "l": "geranylgeranyl diphosphate + H2O => cyclooctat-9-en-7-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16624", "l": "dihydrosanguinarine + H(+) + O2 <=> H2O2 + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35323", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.19", "l": "\"undecaprenyl-diphosphooligosaccharide--protein glycotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55804", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28772", "l": "(2E)-hexadecenoyl-CoA => (9Z)-hexadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170964", "l": "FRS2 binds to active TrkA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53295", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin <=> H(+) + N-carbamoyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.323", "l": "\"(+)-thujan-3-ol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53544", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856951", "l": "PP2A demethylation by PPME1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13441", "l": "H2O + L-cysteate = H(+) + NH4(+) + pyruvate + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.25", "l": "\"L-cysteate sulfo-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177926", "l": "Dephosphorylation of PAG by SHP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30458", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O <=> (-)-geosmin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34219", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.85", "l": "\"2-hydroxymuconate-6-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848818", "l": "PTK6 phosphorylates CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.75", "l": "\"lysostaphin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015121", "l": "phosphoenolpyruvate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75921", "l": "dihydroxyacetone + H(+) + NADPH + NH4(+) => H2O + NADP(+) + serinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22580", "l": "(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.80", "l": "\"2-oxopent-4-enoate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57613", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH => 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76700", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34211", "l": "ecgonine methyl ester + NADP(+) = ecgonone methyl ester + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.334", "l": "\"methylecgonone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372542", "l": "Loading of dopamine into synaptic veiscles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629679", "l": "PDE3A inhibitors bind PDE3A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64649", "l": "(E)-coniferaldehyde + CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928576", "l": "RHOA:GTP binds ROCK, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773218", "l": "CDH19 associates with catenins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56125", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O => AH2 + diphosphate + nonaflavuxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41273", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201443", "l": "Type II receptor phosphorylates type I receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45763", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone <=> dTDP + H(+) + rhodomycin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419451", "l": "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.-", "l": "\"Other protein kinases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193665", "l": "MYD88 dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008496", "l": "mannan endo-1,6-alpha-mannosidase activity", "d": ["Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20538", "l": "H2O + holo-[ACP] => (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23285", "l": "isopentenyl diphosphate => dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791319", "l": "NID1 degradation by MMP19 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614605", "l": "Persulfide sulfur is dioxygenated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68007", "l": "AH2 + chloroethene <=> A + chloride + ethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32673", "l": "ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate => ATP + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618863", "l": "CaMKK binds activated calmodulin in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352864", "l": "glucose [extracellular] <=> glucose [cytosol] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050392", "l": "vicianin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18099", "l": "H(+) + xanthine-8-carboxylate => pteridine-2,4,6,7-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694632", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687455", "l": "HSV1 RIR1 binds RIPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392834", "l": "Activation of EPACs by cAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73884", "l": "guanidine(out) => guanidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45841", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) => 3-oxodecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684006", "l": "KPNA2 translocates NBN to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15178", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33717", "l": "2-hydroxyoctadecanal + phosphoethanolamine => 4-hydroxyeicosasphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23274", "l": "an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP => an N(6)-alkylaminopurine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67767", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76311", "l": "L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48315", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050142", "l": "nitrogenase (flavodoxin) activity", "d": ["Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40780", "l": "2-aminopentanenitrile + H(+) + 2 H2O => L-2-aminopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008312", "l": "7S RNA binding", "d": ["Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54981", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13692", "l": "diphosphate + glycerol <=> glycerol 1-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14005", "l": "H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58337", "l": "a 4-hydroxynonen-1-ol + NADP(+) => a 4-hydroxynonenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31700", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.26", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9793472", "l": "RIPK3 binds p-S9-PRKN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374896", "l": "Uptake of Noradrenaline (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350578", "l": "NQO1 interaction with ODC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76031", "l": "2 H2O2 => O2 + 2 H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77609", "l": "Binding of APOBEC-1 to form editosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13238", "l": "D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68960", "l": "DNA polymerase epsilon binds at the origin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57252", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13610", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73417", "l": "H(+) + methyl isocyanate + viridicatin => (-)-cyclopenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56779", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928617", "l": "EPHB2 binds KALRN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26472", "l": "16-feruloyloxyhexadecanoate + CoA => (E)-feruloyl-CoA + 16-hydroxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086081", "l": "cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42917", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814153", "l": "ADO oxidises 2AET to HTAU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39552", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64964", "l": "dUTP + 2 H2O = dUMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72974", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) <=> 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18567", "l": "9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine => 19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19949", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.15", "l": "\"dihydropteroate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317314", "l": "AKT binds PDPK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814695", "l": "PERP binds desmosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50050", "l": "ADP + cholate(out) + H(+) + phosphate => ATP + cholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29939", "l": "H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43664", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA = 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570528", "l": "SUMOylation of XPC with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61380", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10580", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.11", "l": "\"cAMP-dependent protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54369", "l": "acetaldehyde + H(+) + pyruvate => acetoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102091", "l": "phosphatidylinositol-5-phosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = an 1-phosphatidyl-1D-myo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56193", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72265", "l": "chloride(in) + oxalate(out) => chloride(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70762", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928645", "l": "EPHB:NMDAR binds TIAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35835", "l": "2'-dehydrokanamycin A + H(+) + NADPH = kanamycin A + NADP(+)", "d": [], "t": []}, {"i": "EC:1.1.1.355", "l": "\"2'-dehydrokanamycin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015593", "l": "allose transmembrane transporter activity", "d": ["Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0003991", "l": "acetylglutamate kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691004", "l": "XPC binds RAD23 and CETN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051916", "l": "granulocyte colony-stimulating factor binding", "d": ["Binding to granulocyte colony-stimulating factor, G-CSF."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75356", "l": "H2O + L-mimosine => 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052769", "l": "beta-6-sulfate-N-acetylglucosaminidase activity", "d": ["Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66652", "l": "(2E,6E)-farnesyl diphosphate = african-1-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005521", "l": "lamin binding", "d": ["Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950782", "l": "p-STAT1 binds p-STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40799", "l": "2-methylpropanoyl-CoA + H2O = 2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57191", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] <=> glycolate + H(+) + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36330", "l": "ADP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66405", "l": "ATP + glutathione(in) + H2O + taurocholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804596", "l": "APAF1:CYCS binds APIP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047912", "l": "galacturonokinase activity", "d": ["Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159773", "l": "Furin cleaves pro-protein S to protein S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432946", "l": "PARVB/Affixin interacts with alpha PIX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10343", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-vetispiradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10994", "l": "glyoxylate + H(+) + NADPH => glycolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54566", "l": "a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30582", "l": "H2O + O-phospho-L-threonine <=> L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21178", "l": "5-dehydro-D-gluconate + H(+) + NADPH => L-idonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72185", "l": "mRNA polyadenylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052686", "l": "perillic acid-CoA ligase (AMP-forming) activity", "d": ["Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA."], "t": []}, {"i": "KEGG.REACTION:R06368", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61127", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40303", "l": "A + dodecanedioyl-CoA = (2E)-dodecenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49992", "l": "H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol", "d": [], "t": []}, {"i": "EC:1.14.13.227", "l": "\"propane 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29422", "l": "H(+)(out) + Na(+)(in) <=> H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73757", "l": "2 H(+)(in) + histamine(out) => 2 H(+)(out) + histamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23419", "l": "(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68557", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369052", "l": "ABCAs mediate lipid influx (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64019", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001095", "l": "TFIIE-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67368", "l": "H2O + N-acetyl-L-glutamine = acetate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27442", "l": "NAD(+) + xylitol => D-xylose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27689", "l": "ATP + GDP <=> ADP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848124", "l": "PTK6 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798373", "l": "MDM2 ubiquitinates DYRK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9737780", "l": "MTTP binds lomitapide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14097", "l": "3-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate", "d": [], "t": []}, {"i": "EC:2.6.1.70", "l": "\"aspartate--phenylpyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013435", "l": "RHOD auto-activates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28001", "l": "H2O + thiamine diphosphate <=> H(+) + phosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617207", "l": "SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626549", "l": "IQGAPs bind CALM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64451", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36689", "l": "CoA + H(+) + N-hexadecanoylsphing-4-enine => hexadecanoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3785684", "l": "Fibronectin degradation by CTSG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005462", "l": "UDP-N-acetylglucosamine transmembrane transporter activity", "d": ["Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852716", "l": "Thrombin, ELANE cleave C5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964759", "l": "Alternative endo-mannosidase I route (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047994", "l": "hydroxymethylglutaryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17448", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047330", "l": "polyphosphate-glucose phosphotransferase activity", "d": ["Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10728", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008114", "l": "phosphogluconate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31354", "l": "lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30748", "l": "FAD + H(+) + hexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334794", "l": "FABPs bind LCFAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67371", "l": "H2O + N-acetyl-L-glutamine <=> acetate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685156", "l": "ATR phosphorylates RPA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176445", "l": "SMURF2 binds SMAD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165195", "l": "GTP loading by Rheb (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33510", "l": "sphing-4-enine 1-phosphate <=> (2E)-hexadecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797803", "l": "PTPRD binds SLITRK1-6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50279", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43735", "l": "a triacyl-sn-glycerol + H2O <=> a 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862380", "l": "HSD17B13 binds lipid droplets (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48471", "l": "a ganglioside GM1b (d18:1(4E)) + H2O <=> a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.10", "l": "\"4,4'-diapolycopenoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.5", "l": "\"sphingolipid C4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011598", "l": "DOCKs bind to RhoGEFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029273", "l": "PI3K binds to p-6Y-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58469", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176445", "l": "SMURF2 binds SMAD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18503", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH => ergosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52834", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => 1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38983", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164524", "l": "Fusion of viral membrane with host cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004773", "l": "steryl-sulfatase activity", "d": ["Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20450", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 => 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45316", "l": "H(+) + NADPH + prostaglandin D2 = 11beta-prostaglandin F2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54607", "l": "2-oxoglutarate + decanoyl-CoA + O2 <=> 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10400", "l": "L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.15", "l": "\"glutamine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940134", "l": "FOLR2 binds FOLA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51085", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63385", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24432", "l": "H2O + oxaloacetate = acetate + H(+) + oxalate", "d": [], "t": []}, {"i": "EC:3.7.1.1", "l": "\"oxaloacetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034810", "l": "4,5-dihydroxybenzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390912", "l": "HRH1 binds hist (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74001", "l": "diphosphate + peniprequinolone => dimethylallyl diphosphate + quinolinone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391158", "l": "SIRP alpha binds CD47 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72841", "l": "ADP(in) + CoA(out) => ADP(out) + CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628758", "l": "NEIL1 G83D does not cleave FapyG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008682", "l": "3-demethoxyubiquinol 3-hydroxylase activity", "d": ["Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67589", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42159", "l": "androsterone + H(+) + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40159", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "28.598625914443904", "identifiers": [{"i": "GO:0003674", "l": "molecular_function", "d": ["A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.", "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.47", "l": "\"gingipain K\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76498", "l": "acetyl-CoA + D-glutamate <=> CoA + H(+) + N-acetyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41390", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0004351", "l": "glutamate decarboxylase activity", "d": ["Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209840", "l": "Two DITs combine to form thyroxine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981832", "l": "NMUR2 binds neuromedin-S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21310", "l": "cycloartenol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28913", "l": "H(+)(in) + L-lysine(in) => H(+)(out) + L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32600", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => 3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69495", "l": "O2 + octan-1-ol <=> H2O2 + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451366", "l": "Activation of p38MAPK by DSCAM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052662", "l": "zeaxanthin epoxidase activity", "d": ["Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73858", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose <=> 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.294", "l": "\"chlorophyll(ide) b reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31987", "l": "(S)-2,3-epoxysqualene = baruol", "d": [], "t": []}, {"i": "EC:5.4.99.57", "l": "\"baruol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62136", "l": "dGMP + GTP = dGDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72079", "l": "3 Na(+)(out) + selenate(out) = 3 Na(+)(in) + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58107", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850818", "l": "SPINK9 binds KLK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112342", "l": "Inactivation of MAP2K1 by CDK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.43", "l": "\"prepilin peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047533", "l": "2,5-dioxovalerate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0008253", "l": "5'-nucleotidase activity", "d": ["Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694563", "l": "ABHD10 hydrolyses MPAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641229", "l": "TLE oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41872", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52913", "l": "3-dimethylallyl-4-hydroxymandelate + O2 => 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71652", "l": "a thymidine in DNA + NAD(+) => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17237", "l": "ATP + FMN + H(+) = diphosphate + FAD", "d": [], "t": []}, {"i": "EC:2.7.7.2", "l": "\"FAD synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28822", "l": "5-dehydro-D-gluconate(in) + H(+)(in) <=> 5-dehydro-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617595", "l": "SGTA binds mislocalized membrane protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63862", "l": "(2R,9Z,12Z)-2-hydroperoxyoctadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195378", "l": "Homodimerization of VEGF proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654425", "l": "Activated FGFR4 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57813", "l": "1-chloro-2-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018669", "l": "3-hydroxybenzoate 6-monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34300", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate => 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-874087", "l": "SGT1 binds HSP90 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035248", "l": "alpha-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73250", "l": "ladanein + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19042", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] => (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66972", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose = alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.381", "l": "\"dTDP-Rha:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-rahmnosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13918", "l": "(-)-menthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016308", "l": "1-phosphatidylinositol-4-phosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30000", "l": "ATP + H2O + spermidine(out) => ADP + H(+) + phosphate + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14537", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.20", "l": "\"pyrithiamine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44405", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29701", "l": "dimethyl sulfoxide(out) => dimethyl sulfoxide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69010", "l": "2-nitrobutanedioate + 4 H2O + 3 NADP(+) => 2 H(+) + L-aspartate + 3 NADPH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68282", "l": "CoA + O-pentanoyl-L-seryl-[protein] => L-seryl-[protein] + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68611", "l": "Formation of ORC(1-5) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19911", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (S)-lactate + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29616", "l": "alpha-maltotriose + beta-maltose => alpha-maltotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57492", "l": "H2O + oxaloacetate + propanoyl-CoA = 2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77343", "l": "N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42652", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.314", "l": "\"diphthine methyl ester synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013023", "l": "RHOB GEFs activate RHOB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13898", "l": "chorismate => prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71173", "l": "H(+)(out) + L-cysteine(in) + Na(+)(in) => H(+)(in) + L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47963", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18554", "l": "(2R,3S)-tartrate + NAD(+) => dihydroxyfumarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11121", "l": "cyanate + 3 H(+) + hydrogencarbonate => 2 CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32563", "l": "(2E)-geranyl diphosphate = alpha-terpinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.115", "l": "\"alpha-terpinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784861", "l": "HSPG binds LPL dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018747", "l": "RHOQ GEFs activate RHOQ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55209", "l": "(4R)-hydroxysphinganine 1-phosphate => (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29249", "l": "3 H(+)(in) + 2 Na(+)(out) => 3 H(+)(out) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008076", "l": "WWP1 polyubiquitinates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204798", "l": "Interaction of Tie2 and p85 of PI3K (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39086", "l": "3-oxododecanedioyl-CoA + CoA <=> acetyl-CoA + decanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931981", "l": "RUNX1 binds ESR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70570", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49609", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28250", "l": "acetyl-CoA + H(+) + malonyl-CoA = acetoacetyl-CoA + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.194", "l": "\"acetoacetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56848", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine = H(+) + reumycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62000", "l": "3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67780", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30148", "l": "FADH2 + NAD(+) => FAD + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018774", "l": "RHOBTB1 binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44476", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23597", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031816", "l": "P2Y6 nucleotide receptor binding", "d": ["Binding to a P2Y6 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37222", "l": "A + D-valine + H2O <=> 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944218", "l": "Association of procollagen type VIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2520883", "l": "Phosphorylated condensin I promotes condensation of prometaphase chromosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028583", "l": "Phosphorylation of YAP by LATS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193519", "l": "DHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46363", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73738", "l": "O2 + trans-resveratrol <=> 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030110", "l": "HLA-C specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297275", "l": "CD9:Izumo Binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17247", "l": "6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2 => 3-hydroxyanthranilate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29843", "l": "ATP + CoA + propanoate = ADP + phosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586559", "l": "Leptin Binds Leptin Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41870", "l": "3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] => decanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23117", "l": "4-hydroxybenzoate + ATP + CoA => 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043794", "l": "formate dehydrogenase (coenzyme F420) activity", "d": ["Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420."], "t": []}, {"i": "EC:1.2.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29894", "l": "ATP + H2O + L-histidine(out) <=> ADP + H(+) + L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40087", "l": "22-hydroxydocosanoate + NAD(+) = 22-oxodocosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58955", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0005350", "l": "pyrimidine nucleobase transmembrane transporter activity", "d": ["Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52444", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12998", "l": "(E)-feruloyl-CoA + galactarate => 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36015", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26183", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.78", "l": "\"phylloquinone omega-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46528", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.876091073600094", "identifiers": [{"i": "GO:0016413", "l": "O-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49107", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55187", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 <=> 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76496", "l": "acetyl-CoA + D-glutamate => CoA + H(+) + N-acetyl-D-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24401", "l": "ATP + UMP => ADP + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.2", "l": "\"pepsin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53579", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23252", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14806", "l": "ATP + D-allose => ADP + D-allose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0016682", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.10.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34221", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49523", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 <=> an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67777", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.4", "l": "\"4-hydroxy-3-methylbut-2-enyl diphosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71441", "l": "L-dopa(in) + L-phenylalanine(out) => L-dopa(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043732", "l": "6-hydroxynicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071820", "l": "N-box binding", "d": ["Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047817", "l": "D-arginase activity", "d": ["Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58560", "l": "15alpha-stemmadenine intermediate II + NADP(+) = 15alpha-stemmadenine intermediate I + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64706", "l": "benzophenone + H(+) + NADH => diphenylmethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102648", "l": "D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity", "d": ["Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate = D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45360", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine = (11Z)-eicosenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781953", "l": "YOD1 binds VCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214880", "l": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73798", "l": "dimethylallyl diphosphate + neoechinulin A <=> diphosphate + isoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247497", "l": "ERBB3 binds neuregulins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13310", "l": "H2O + NAD(+) + vanillin => 2 H(+) + NADH + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874849", "l": "CREBRF binds CREB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63689", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12843", "l": "L-alanine + pyridoxal => pyridoxamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102701", "l": "tricyclene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) = tricyclene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467466", "l": "ABCA4 mediates atRAL transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71446", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) <=> 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76085", "l": "(11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189457", "l": "Mitochondrial intermembrane PRIN9 translocates to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0031072", "l": "heat shock protein binding", "d": ["Binding to a heat shock protein, a protein synthesized or activated in response to heat shock."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36549", "l": "CoA + H(+) + N-(octadecanoyl)-sphinganine => octadecanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419644", "l": "Transphosphorylation of pLIMK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67209", "l": "H2O + melatonin => 5-methoxytryptamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983156", "l": "Polyubiquitination of substrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182986", "l": "CBL-mediated ubiquitination of CIN85 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28514", "l": "(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14574", "l": "D-glucarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24365", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) => 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27788", "l": "CO2 + NADH + succinyl-CoA => 2-oxoglutarate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63937", "l": "3 a ubiquinone + protoporphyrinogen IX => 3 a ubiquinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0140489", "l": "molecular template activity", "d": ["The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56010", "l": "4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982617", "l": "CYGB:O2 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24039", "l": "a ribonucleoside 5'-phosphate + ATP <=> a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13892", "l": "FAD + H2O <=> AMP + FMN + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12051", "l": "3-oxoadipate + succinyl-CoA <=> 3-oxoadipyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36688", "l": "hexadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71842", "l": "dehydroepiandrosterone 3-sulfate(out) <=> dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47649", "l": "D-ribitol 5-phosphate + H2O => phosphate + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53815", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299725", "l": "PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177923", "l": "Sustained activation of SRC kinase by SHP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34666", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12993", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.10", "l": "\"cyclohex-1-ene-1-carbonyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015663", "l": "nicotinamide mononucleotide transmembrane transporter activity", "d": ["Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33081", "l": "adenine + dehypoxanthine futalosine => 6-amino-6-deoxyfutalosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0051377", "l": "mannose-ethanolamine phosphotransferase activity", "d": ["Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor."], "t": []}, {"i": "REACT:R-HSA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13483", "l": "AMP + diphosphate + L-methionyl-tRNA(Met) => ATP + L-methionine + tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39043", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735302", "l": "GATA4, GATA6, and ISL1:LDB1 bind the HAND2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0001216", "l": "DNA-binding transcription activator activity", "d": ["A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51611", "l": "(R)-2-hydroxyglutarate + pyruvate <=> (R)-lactate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817936", "l": "Expression of KDM4E in the embryo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51044", "l": "indole-3-pyruvate imine dimer = CO2 + NH4(+) + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69229", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate => an epithionitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140774", "l": "NAD-dependent protein depalmitoylase activity", "d": ["Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:70563", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730505", "l": "SARS-CoV-2 3a binds to UVRAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47031", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine <=> [DsrC protein]-disulfide + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72465", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein] => L-threonyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17642", "l": "H(+) + L-arginine => agmatine + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.16", "l": "\"Xaa-Trp aminopeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39331", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21823", "l": "L-homocysteine + S-adenosyl-L-methionine <=> H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602484", "l": "Activation of proMMP11 by FURIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77185", "l": "(5'S,6'R)-C-glycyluridine + acetaldehyde => L-threonine + uridine-5'-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65487", "l": "hexan-1-ol + hexanoyl-CoA <=> CoA + hexyl hexanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14871", "l": "acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114284", "l": "Release of Cytochrome c from mitochondria (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042975", "l": "peroxisome proliferator activated receptor binding", "d": ["Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332359", "l": "Active calmodulin binds CAMK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888589", "l": "Release of GABA at the synapse (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17824", "l": "hydrogen cyanide + L-cysteine <=> 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62125", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP => a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64229", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25464", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + longifolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24727", "l": "N-demethylindolmycin + S-adenosyl-L-methionine => H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022315", "l": "MECP2 binds DGCR8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20751", "l": "2-oxoglutarate + O2 + penicillin N <=> CO2 + deacetoxycephalosporin C + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68624", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}, {"i": "EC:4.4.1.39", "l": "\"C-phycoerythrin alpha-cysteine-82 phycoerythrobilin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009026", "l": "tagaturonate reductase activity", "d": ["Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29987", "l": "adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15247", "l": "a fatty acid + glycerol + H(+) => a monoacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187586", "l": "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191763", "l": "snRNP:Snurportin complex formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18969", "l": "a long-chain fatty acid + H(+) + hnu = a long-chain alkane + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675896", "l": "PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641111", "l": "Parkin transfers Ub to misfolded proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41663", "l": "dihydrosanguinarine + NAD(+) <=> NADH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62991", "l": "dodecanamide + H2O <=> dodecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102380", "l": "steviolbioside glucosyltransferase activity (rebaudioside B forming)", "d": ["Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54385", "l": "a 3-oxo-5alpha-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54891", "l": "(1S,2S)-OPC-8 + ATP + CoA <=> AMP + diphosphate + OPC8-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15181", "l": "an acyl-CoA(out) + ATP + H2O = ADP + an acyl-CoA(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.4", "l": "\"ABC-type fatty-acyl-CoA transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102256", "l": "neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarohexaose + H2O = 3,6-anhydro-alpha-L-galactopyranose + agaropentaose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21668", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": [], "t": []}, {"i": "EC:7.6.2.10", "l": "\"ABC-type glycerol 3-phosphate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42458", "l": "zymosterol => 4alpha-methylzymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44726", "l": "(2E)-fatty aldehyde + H(+) + NADPH => 2,3-saturated fatty aldehyde + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58009", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805276", "l": "CDK5 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71921", "l": "3 Na(+)(in) + succinate(in) => 3 Na(+)(out) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55537", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75053", "l": "chenodeoxycholate(in) => chenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71282", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) <=> chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74127", "l": "peonidin + UDP-alpha-D-galactose = peonidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60050", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58032", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57436", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] = acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866321", "l": "VLDL binds APOC1 and APOC4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379993", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42215", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61842", "l": "brassicasterol 3-beta-D-glucoside + H(+) + UDP => brassicasterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62213", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] => gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68708", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218814", "l": "PAK2 autophorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213201", "l": "Formation of collagen fibres (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37244", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043880", "l": "crotonyl-CoA reductase activity", "d": ["Catalysis of the reduction of crotonyl-CoA to butyryl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009979", "l": "16:0 monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799761", "l": "TP53 binds PPP1R13L (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64311", "l": "3-aminobutanoate + pyruvate <=> acetoacetate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190829", "l": "Lysosomal degradation of gap junction plaques (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38181", "l": "19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788623", "l": "p-Y-STATs translocate to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22182", "l": "(S)-norcodamine + H(+) + S-adenosyl-L-homocysteine => (S)-norreticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018766", "l": "RHOU binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674022", "l": "BRAP autoubiquitinates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75134", "l": "neomorphinone <=> morphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11942", "l": "CO2 + L-ornithine + NH4(+) => 2 H(+) + H2O + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26189", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67339", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39535", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA = (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015199", "l": "amino-acid betaine transmembrane transporter activity", "d": ["Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432143", "l": "PECAM-1 binds PP2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050577", "l": "GDP-L-fucose synthase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948582", "l": "miR-17 microRNA binds VAPA mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411373", "l": "NLK translocates to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114254", "l": "CYCS binds to APAF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75537", "l": "(R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O => FMNH2 + N-acetyl-S-methyl-L-cysteine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23734", "l": "ADP + CO2 + isopentenyl diphosphate + phosphate => (R)-5-diphosphomevalonate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73866", "l": "dopamine(out) <=> dopamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77567", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687097", "l": "p-S857 NCOA3 binds ETV4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74937", "l": "(3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate => (3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9671145", "l": "DKC1 binds SHQ1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212642", "l": "L-Glutamine transport into neurons (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55701", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O => an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67217", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34399", "l": "9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}, {"i": "EC:1.13.11.68", "l": "\"9-cis-beta-carotene 9',10'-cleaving dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74394", "l": "methylamine(out) <=> methylamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964471", "l": "DREAM complex binds the CDC25A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75949", "l": "L-ornithine + taurocyamine => L-arginine + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70517", "l": "3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202291", "l": "Activation of Lck (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35025", "l": "hydroquinone O-beta-D-glucopyranoside(in) => hydroquinone O-beta-D-glucopyranoside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052922", "l": "hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.41", "l": "\"isocitrate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25807", "l": "H2O + O2 + spermine <=> 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31470", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-glucosyl) crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23698", "l": "D-glucuronate + H(+) + H2O => myo-inositol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52558", "l": "3-dehydro-4-O-phospho-D-erythronate + ADP + H(+) => 3-dehydro-D-erythronate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54612", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 = 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103078", "l": "quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose = quercetin-3-rhamnoside-7-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047449", "l": "2-dehydro-3-deoxy-L-arabinonate dehydratase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426489", "l": "RISC binds inexactly matching target RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0003725", "l": "double-stranded RNA binding", "d": ["Binding to double-stranded RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700171", "l": "Active ALK phosphorylates PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18389", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-xylose", "d": [], "t": []}, {"i": "EC:2.7.7.11", "l": "\"UTP--xylose-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061628", "l": "H3K27me3 modified histone binding", "d": ["Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167429", "l": "The receptor:G-protein complex  binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33961", "l": "6'''-deamino-6'''-oxoneomycin C + L-glutamate => 2-oxoglutarate + neomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099520", "l": "monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential", "d": ["Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53419", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine <=> 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72504", "l": "glutarate(in) + prostaglandin F2alpha(out) => glutarate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35619", "l": "L-idarate = D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70884", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) => H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955844", "l": "RBKS phosphorylates ribose to R5P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804596", "l": "APAF1:CYCS binds APIP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27715", "l": "GMP + H2O => guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12024", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline = D-glucose + O-sinapoylcholine", "d": [], "t": []}, {"i": "EC:2.3.1.91", "l": "\"sinapoylglucose--choline O-sinapoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.906202702420444", "identifiers": [{"i": "GO:0005228", "l": "intracellular sodium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-392749", "l": "Transport of L1 into endosomes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51225", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64000", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692764", "l": "MAPK6 binds CCND3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.53", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74262", "l": "H2O + L-homoseryl-tRNA(Lys) <=> H(+) + L-homoserine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19993", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44494", "l": "3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42929", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51572", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43426", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34050", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 <=> 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805061", "l": "CK2 binds FACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0071913", "l": "citrate secondary active transmembrane transporter activity", "d": ["Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770141", "l": "Formation of the Spliceosomal C* complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68324", "l": "1D-myo-inositol 2,5-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601926", "l": "RNA polymerase II polymerizes primary piRNA transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199425", "l": "PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445700", "l": "Myosin Binds ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659611", "l": "ANO1 inhibitors bind ANO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031819", "l": "P2Y10 nucleotide receptor binding", "d": ["Binding to a P2Y10 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28206", "l": "2'-deoxyuridine + ATP = ADP + dUMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29937", "l": "cytosine(out) + H(+)(out) => cytosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44550", "l": "an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49944", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate = (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693198", "l": "RHOD binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2152276", "l": "Secretion of transmembrane collagens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65508", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 = H2O2 + NH4(+) + pre-mycofactocin", "d": [], "t": []}, {"i": "EC:1.4.3.26", "l": "\"pre-mycofactocin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139941", "l": "Binding of IP3 to IP3 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75364", "l": "thymidine(in) => thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40643", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68110", "l": "H(+) + keto-L-fructose + NADH => L-glucitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76487", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396941", "l": "Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61850", "l": "cholesteryl 3-beta-D-glucoside + H(+) + UDP => cholesterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202328", "l": "Translocation of PKC theta to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67379", "l": "glycyl-L-histidine + H2O <=> glycine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425861", "l": "Activation of Protein Kinase C novel isoforms (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56800", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide = cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351948", "l": "Mitochondrial recruitment of Drp1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24179", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27637", "l": "5-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134954", "l": "DHX9 binds DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70943", "l": "L-isoleucine(in) = L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46230", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein] => apo-[peptidyl-carrier protein] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912790", "l": "CBL binds CRK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65106", "l": "aculene B + holo-[peptidyl-carrier protein] => aculene D + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54142", "l": "5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA precursor + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32956", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36953", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351849", "l": "Caspase-mediated cleavage of Etk (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24117", "l": "(2E)-geranyl diphosphate + H2O => (S)-linalool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634850", "l": "NPAS4 binds ARNT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050082", "l": "maltose phosphorylase activity", "d": ["Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38592", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine => chloroorienticin B + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62285", "l": "2 ATP + L-proline + L-tryptophan + NADPH => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000074", "l": "TCN2 binds RCbl in the circulation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102847", "l": "1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75905", "l": "ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein] => ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54343", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604712", "l": "Initial activation of proMMP7 by trypsin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662466", "l": "XYLB phosphorylates D-xylulose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844438", "l": "NLRP1 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609746", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2B (GRIN2B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18849", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] = a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54049", "l": "(2E,6E)-farnesyl diphosphate + H2O => 4-epi-cubebol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9626914", "l": "α2-agonists bind ADRA2A,B,C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675214", "l": "Formation of the WRAD complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47716", "l": "4-pregnen-20,21-diol-3-one + NAD(+) = 21-hydroxyprogesterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-176175", "l": "Stalling of DNA replication fork and RPA binding (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54499", "l": "ent-copalyl diphosphate <=> diphosphate + ent-atiserene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22964", "l": "H(+) + L-ornithine = CO2 + putrescine", "d": [], "t": []}, {"i": "EC:4.1.1.17", "l": "\"ornithine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71524", "l": "adenine(out) => adenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17402", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22832", "l": "H2O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.13", "l": "\"formimidoylglutamate deiminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49988", "l": "acetone + H(+) + NADPH + O2 = H2O + methyl acetate + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.226", "l": "\"acetone monooxygenase (methyl acetate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30371", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52658", "l": "a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH => a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75314", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) <=> D-serine(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373748", "l": "SEMA4D interacts with CD72 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34987", "l": "(S)-lactate(in) = (S)-lactate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34178", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA <=> 4-hydroxycoumarin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190261", "l": "FGFR3c binds to FGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757686", "l": "SERPINA6 binds PREDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0004749", "l": "ribose phosphate diphosphokinase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0046921", "l": "alpha-(1->6)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996755", "l": "ZFPM proteins bind GATA proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814090", "l": "NatC acetylates ARFFRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75238", "l": "TRAIL binds TRAIL receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45915", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638104", "l": "UGCG transfers glucose to ceramide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13108", "l": "glycerol 2-phosphate + H2O <=> glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62605", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102202", "l": "soladodine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + solasodine = UDP + solasodine 3-O-beta-D-glucopyranoside + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687465", "l": "MRN complex binds RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20497", "l": "a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990585", "l": "hydroxyproline O-arabinosyltransferase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1176059", "l": "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006870", "l": "IL21 receptor STAT phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17340", "l": "catechol + O2 <=> (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68611", "l": "Formation of ORC(1-5) complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23447", "l": "(S)-lactate + NAD(+) <=> H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61603", "l": "[DsbD protein]-disulfide + [protein]-dithiol <=> [DsbB protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18896", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47631", "l": "glyoxylate + H2O + propanoyl-CoA <=> 3-methylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26119", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.17.7.1", "l": "\"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102319", "l": "2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine = H+ + 2'-N-acetylparomamine(2+) + UDP(3-)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20569", "l": "H2O + L-arginine = L-ornithine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.1", "l": "\"arginase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20008", "l": "an alpha-D-glucuronoside + H2O <=> an alcohol + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754129", "l": "CDK6 inhibitors bind CDK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050289", "l": "spermidine dehydrogenase activity", "d": ["Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0015368", "l": "calcium:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)."], "t": []}, {"i": "REACT:R-HSA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66030", "l": "(5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10403", "l": "L-glutamine + pyruvate <=> 2-oxoglutaramate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3240957", "l": "Formation of PRC2-EZH2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793096", "l": "MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370500", "l": "PRLR binds SCF beta-TrCP complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55415", "l": "[phosphate](n) + GTP <=> [phosphate](n+1) + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44644", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389463", "l": "Proteinase-activated receptors can bind thrombin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050449", "l": "casbene synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0070336", "l": "flap-structured DNA binding", "d": ["Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33263", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.40", "l": "\"phenylalanine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77277", "l": "1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010174", "l": "nucleoside transmembrane transporter activity, against a concentration gradient", "d": ["Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29489", "l": "cis-muurola-3,5-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26152", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.78", "l": "\"6,7-dimethyl-8-ribityllumazine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52817", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68385", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68343", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O <=> (R)-S-sulfopantetheine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671772", "l": "p-T38-PPP1R14A binds MLCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008330", "l": "protein tyrosine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53631", "l": "(2E,6E)-farnesyl diphosphate <=> (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871226", "l": "RET binds GFRA1,GFRA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140837", "l": "RNA polymerase II CTD heptapeptide repeat S7 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 7)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58180", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37917", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18569", "l": "an aromatic aldehyde + H2O + O2 = an aromatic carboxylate + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.9", "l": "\"aryl-aldehyde oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24225", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) => 4-methylcatechol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30775", "l": "H2O + O2 + pyridoxamine = H2O2 + NH4(+) + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27536", "l": "(3R,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70288", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11600", "l": "ATP + CMP = ADP + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36858", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O <=> acetate + an S-substituted L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23927", "l": "pppGp(2'-5')A <=> 2',3'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35322", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA <=> 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.16", "l": "\"steroid 21-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49511", "l": "phosphinomethylmalate <=> 2-(phosphinatomethylidene)butanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72327", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate = 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25031", "l": "ADP-D-ribose + phosphate => ADP-alpha-D-ribose 1''-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73797", "l": "FAICAR => IMP + H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211968", "l": "CYP2W1 oxidises INDOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76416", "l": "Benzene is hydroxylated to phenol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19129", "l": "ATP + thymidine = ADP + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374662", "l": "Translocation of Ezrin to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445699", "l": "ATP Hydrolysis By Myosin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617815", "l": "BBSome binds RAB3IP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670673", "l": "FIX is secreted (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428260", "l": "DEGS2 oxygenates dihydroceramide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56928", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008613", "l": "diuretic hormone activity", "d": ["The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077421", "l": "FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72768", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH => 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23282", "l": "CoA + S-acetylcysteamine => acetyl-CoA + cysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56350", "l": "2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+) => 4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990929", "l": "sulfoquinovosidase activity", "d": ["Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032054", "l": "LXA4/B4 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0005524", "l": "ATP binding", "d": ["Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator."], "t": []}, {"i": "REACT:R-HSA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59055", "l": "D-lysine + H(+) <=> cadaverine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938887", "l": "PML binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71273", "l": "H(+)(out) + thiamine(in) => H(+)(in) + thiamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665726", "l": "ERBB2 binds pertuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16600", "l": "ATP + NH4(+) + UTP <=> ADP + CTP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690493", "l": "RHOB binds effectors on endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67198", "l": "acetate + serotonin => H2O + N-acetylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693540", "l": "MRN activates ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.61", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46759", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696605", "l": "USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45243", "l": "a (3E,5Z)-dienoyl-CoA <=> a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52864", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34141", "l": "CO2 + Delta(9)-tetrahydrocannabinol => Delta(9)-tetrahydrocannabinolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49146", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46886", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13565", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.12", "l": "\"teichoic acid poly(glycerol phosphate) polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54800", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391941", "l": "BLT receptors can bind LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32128", "l": "2-oxoglutarate + L-proline + O2 => cis-4-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44200", "l": "12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11975", "l": "4 Fe(2+) + 6 H2O + O2 <=> 12 H(+) + 4 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35652", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA => an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72356", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) => dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51819", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19050", "l": "(5R)-5-hydroxy-L-lysine + GTP => (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39588", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70667", "l": "1PYR-5COOH spontaneously hydrolyses to L-GluSS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617179", "l": "PRKACA phosphorylates TNNI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20037", "l": "D-sorbitol 6-phosphate + NADP(+) = aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.200", "l": "\"aldose-6-phosphate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57170", "l": "2-oxoglutarate + FADH2 => (R)-2-hydroxyglutarate + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59550", "l": "H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone => N,N',N''-triacetylchitotriose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004127", "l": "cytidylate kinase activity", "d": ["Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP."], "t": []}, {"i": "EC:2.7.4.14", "l": "\"UMP/CMP kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52696", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807106", "l": "PTEN undergoes monoubiquitination (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015132", "l": "prostaglandin transmembrane transporter activity", "d": ["Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73871", "l": "(R)-noradrenaline(out) = (R)-noradrenaline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046180", "l": "KSPG is secreted from the cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19018", "l": "(6S)-NADHX + ATP => ADP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61986", "l": "NAD(+) + ubiquinol-10 => H(+) + NADH + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70530", "l": "H(+) + N-acyl-3-oxosphinganine + NADH <=> an N-acylsphinganine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047404", "l": "glucuronosyl-disulfoglucosamine glucuronidase activity", "d": ["Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43386", "l": "ADP + H(+) + N(omega)-phospho-L-arginyl-[protein] => ATP + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48997", "l": "3-methylcatechol + O2 => 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45748", "l": "(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.6", "l": "\"leghemoglobin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23399", "l": "H2O + phloretin <=> 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173740", "l": "Factor B binds to C3(H2O) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52127", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35938", "l": "2 ATP + L-proline + L-tryptophan <=> 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53128", "l": "delta-carotene = epsilon-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43588", "l": "a globoside NORint + UDP-alpha-D-galactose = a globoside NOR2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60814", "l": "CO2 + gibberellin A12 + H(+) + succinate => 2-oxoglutarate + gibberellin A12 aldehyde + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27438", "l": "2 glutathione amide + H2O2 => glutathione amide disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70692", "l": "ornithine => putrescine + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14509", "l": "2-oxoglutarate + mugineate + O2 = 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264615", "l": "Loading of acetylcholine in synaptic vesicles (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39811", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10027", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39626", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082391", "l": "Trimerization of HSF1 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70351", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20864", "l": "alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.216", "l": "\"trehalose 6-phosphate phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17784", "l": "H2O + N-formyl-L-methionine <=> formate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37033", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-ribonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32690", "l": "(2E)-geranyl diphosphate <=> diphosphate + tricyclene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43737", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67593", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O => (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64143", "l": "an N-(fatty acyl)-L-asparagine + H2O <=> a fatty acid + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67820", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46017", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15003", "l": "5-dehydro-D-fructose + H(+) + NADPH => keto-L-sorbose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58051", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA <=> 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46106", "l": "corticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.1", "l": "\"tyrosinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173680", "l": "Activation of C5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30051", "l": "fluoroacetate + H2O = fluoride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15429", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.342", "l": "\"anaerobilin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592398", "l": "Activation of proMMP8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52526", "l": "20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68926", "l": "AMP + diphosphate + hexanal + NADP(+) => ATP + H(+) + hexanoate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68988", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26427", "l": "ATP + H2O + L-glutamine + UTP => ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64751", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013711", "l": "HES1 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950175", "l": "Expression of Glutathione S-transferase omega-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849463", "l": "PTK6 phosphorylates SFPQ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034561", "l": "1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity", "d": ["Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873917", "l": "Translocation of STAT1 dimer to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798611", "l": "TP53 stimulates and ZNF420 inhibits TP53AIP1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912388", "l": "NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050227", "l": "pteridine oxidase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0140666", "l": "annealing activity", "d": ["An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule."], "t": []}, {"i": "REACT:R-HSA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29926", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46011", "l": "CoA + NAD(+) + pentanal <=> H(+) + NADH + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74287", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018826", "l": "RHOT2 hydrolyzes GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008176", "l": "tRNA (guanine(46)-N7)-methyltransferase activity", "d": ["Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193695", "l": "IRAK interacts with TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30149", "l": "FAD + 2 H(+) + NADH => FADH2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20584", "l": "H2O + NAD(+) + NH4(+) <=> 2 H(+) + hydroxylamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27750", "l": "2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32756", "l": "(2S)-naringenin + 2-oxoglutarate + O2 => apigenin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19703", "l": "a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP => a flavonol 3-O-glycoside + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106369", "l": "(deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP."], "t": []}, {"i": "RHEA:62124", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050700", "l": "CARD domain binding", "d": ["Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362549", "l": "Hh-Np traffics to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16927", "l": "(E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-caffeoyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004307", "l": "ethanolaminephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.52", "l": "\"indoleamine 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030021", "l": "extracellular matrix structural constituent conferring compression resistance", "d": ["A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016785", "l": "selenotransferase activity", "d": ["Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.9.1.-", "l": "\"Selenotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806412", "l": "TP53 and AP-1 bind the MSH2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044018", "l": "histone H3K36 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48911", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171026", "l": "Guanine nucleotide exchange on RAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683664", "l": "GSK3 phosphorylates Nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198508", "l": "MDH1 oxidizes MAL to OA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68123", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047651", "l": "alkylhalidase activity", "d": ["Catalysis of the reaction: bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60415", "l": "H2O + monoglucosyl-enterobactin <=> [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58959", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48359", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57840", "l": "1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63443", "l": "(2R)-3-phosphoglycerate + GTP + H(+) <=> 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68168", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019785", "l": "ISG15-specific peptidase activity", "d": ["A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52984", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] = 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53081", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796070", "l": "NFE2L2 dependent CCL2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31236", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate => (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442387", "l": "ZIP8 mediates zinc influx into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15771", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) => adenosylcob(III)inamide + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21124", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675790", "l": "MTORC1 dissociates from ULK complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635861", "l": "NUMB:ITCH binds GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9844955", "l": "CLN3 transports GalCer to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197963", "l": "DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20829", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.126913850795333", "identifiers": [{"i": "GO:0015651", "l": "quaternary ammonium group transmembrane transporter activity", "d": ["Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76859", "l": "3-aminopentane + H2O + NAD(+) = H(+) + NADH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863718", "l": "AGFG1 binds VAMP7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70821", "l": "L-homoarginine(out) + L-ornithine(in) => L-homoarginine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696274", "l": "RND1 binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047671", "l": "cyclopeptine synthase activity", "d": ["Catalysis of the reaction: anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13889", "l": "FAD + H2O = AMP + FMN + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.18", "l": "\"FAD diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033722", "l": "malonate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25723", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209925", "l": "DIT and MIT combine to form triiodothyronine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18686", "l": "H(+) + NADPH + O2 + pentachlorophenol => 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50267", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109639", "l": "Formation of the closed pre-initiation complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34462", "l": "8-hydroxycopalyl diphosphate + H2O <=> diphosphate + sclareol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17279", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O => 6-phospho-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46914", "l": "H(+) + juvenile hormone III carboxylate + methanol => H2O + juvenile hormone III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68898", "l": "4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-hydroxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30841", "l": "UDP-N-acetyl-beta-L-fucosamine => UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41708", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44809", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) => 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937989", "l": "RUNX1 binds PRC1 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21734", "l": "anthranilate + H(+) + L-glutamate + pyruvate => chorismate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679239", "l": "ULK complex translocates to the ER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33281", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389919", "l": "Grb2 binds pBTLA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690461", "l": "FKBP1A binds tacrolimus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29582", "l": "Fe(2+)(in) + H(+)(in) <=> Fe(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64551", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] <=> (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27510", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004851", "l": "uroporphyrin-III C-methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726949", "l": "PTGIR binds PTGIR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16243", "l": "a ribonucleoside 5'-diphosphate + H(+) + sucrose => an NDP-alpha-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10441", "l": "D-glucono-1,5-lactone + H2O => D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762209", "l": "BACH1 is phosphorylated at tyrosine 483 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003941", "l": "L-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-serine = pyruvate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30552", "l": "acetyl-CoA + beta-D-glucose => 6-O-acetyl-beta-D-glucose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77421", "l": "(2S,3E)-2-hydroxyhept-3-enenitrile => (E)-hex-2-enal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35778", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose <=> 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950778", "l": "p-Y693-STAT4 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947499", "l": "Exchange of oxygen with sulfur in MoCo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592244", "l": "AMPK phosphorylates PPARGC1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72103", "l": "Formation of pre-mRNPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373746", "l": "SEMA4D interacts with CD45 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65829", "l": "H2O + neryl diphosphate => diphosphate + nerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.69", "l": "\"biflaviolin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001085", "l": "arabinogalactan binding", "d": ["Binding to arabinogalactan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23045", "l": "H(+) + N,N-dihydroxy-L-tyrosine => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14485", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.172", "l": "\"10-epi-juneol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75075", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine = dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13099", "l": "a (2E)-enoyl-[ACP] + H2O => a (3R)-hydroxyacyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624133", "l": "ARL3:GTP binds the UNC119B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169402", "l": "ISGylation of E2 conjugating enzymes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202127", "l": "eNOS synthesizes NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714483", "l": "RAC2 translocates to the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114671", "l": "vWF binds to collagen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51563", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine <=> (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52910", "l": "3-dimethylallyl-4-hydroxymandelate + CO2 => 3-dimethylallyl-4-hydroxyphenylpyruvate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65052", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) = 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65535", "l": "2-methylbutan-1-ol + hexanoyl-CoA <=> 2-methylbutyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43557", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13043", "l": "5,6-dihydroxyindole-2-carboxylate => L-dopachrome", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70481", "l": "TPI1 isomerizes GA3P to DHAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19187", "l": "2-hydroxyglutarate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52177", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12582", "l": "H(+) + NADH + pyruvate + taurine => H2O + NAD(+) + tauropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932327", "l": "NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23994", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5604929", "l": "Activated protein C binds Protein S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873921", "l": "Binding of STAT1 to p-IFNGR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156699", "l": "Inactivation of Wee1 kinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46406", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031624", "l": "ubiquitin conjugating enzyme binding", "d": ["Binding to a ubiquitin conjugating enzyme, any of the E2 proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62801", "l": "2 7-demethylsiderin + NADPH + O2 => 2 H2O + NADP(+) + orlandin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950737", "l": "IL23R binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0051003", "l": "ligase activity, forming nitrogen-metal bonds, forming coordination complexes", "d": ["Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex."], "t": []}, {"i": "EC:6.6.1.-", "l": "\"Forming coordination complexes\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62189", "l": "9alpha-copalyl diphosphate => diphosphate + syn-isopimara-7,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27399", "l": "beta-D-glucose + dichloroarcyriaflavin A => 4'-demethylrebeccamycin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73519", "l": "dUTP(out) + UTP(in) = dUTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60211", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 <=> 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351894", "l": "Caspase mediated cleavage of BAP31 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004835", "l": "tubulin-tyrosine ligase activity", "d": ["Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27851", "l": "glycine + phenylacetyl-CoA => CoA + H(+) + phenylacetylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22703", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68755", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] <=> alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849085", "l": "ARHGAP35 binds RHOA:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33753", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.35", "l": "\"gelatinase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71549", "l": "5-N(alpha)-glycyl-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047122", "l": "quinaldate 4-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + quinaldate = AH(2) + kynurenate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903877", "l": "21-deoxycortisol binding", "d": ["Binding to 21-deoxycortisol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48916", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20210", "l": "ATP + xylitol => ADP + H(+) + xylitol 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033568", "l": "lactoferrin receptor activity", "d": ["Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65938", "l": "beta-D-glucose => beta-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45737", "l": "(3E)-hexenoyl-CoA => (2E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102104", "l": "demethoxycurcumin synthase activity", "d": ["Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110211", "l": "NTHL1 glycosylase mediated recognition and binding of thymine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16989", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16060", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176517", "l": "SULTs transfer (SO4)2- group to PREG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54470", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate => 1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717382", "l": "SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47737", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46459", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654425", "l": "Activated FGFR4 binds SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42261", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] => 3-oxononanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50370", "l": "3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+) => 2-methylbutan-2-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250217", "l": "ARL2:GTP binds ARL2BP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50436", "l": "prostaglandin H1 = prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53699", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645137", "l": "Activator phosphorylates STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65588", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422454", "l": "Polysialylation of NCAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52018", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72331", "l": "3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56943", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29649", "l": "alpha-D-glucose 1-phosphate + alpha-maltotetraose => alpha-maltopentaose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021050", "l": "HSBP1 oligomer binds ESRs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "43.956472379304415", "identifiers": [{"i": "GO:0004888", "l": "transmembrane signaling receptor activity", "d": ["Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction."], "t": []}, {"i": "REACT:R-HSA-193672", "l": "Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981610", "l": "Neuroglobin binds oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34042", "l": "2-oxoglutarate + neamine <=> 6'-oxoparomamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48668", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73577", "l": "(E,E)-piperoyl-AMP + diphosphate => (E,E)-piperate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19887", "l": "(S)-scoulerine + H(+) + H2O2 => (S)-reticuline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54504", "l": "all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41694", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45311", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide <=> 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71949", "l": "N-acetyl-L-aspartate(in) + 3 Na(+)(in) => N-acetyl-L-aspartate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001409", "l": "guanine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55798", "l": "H2O + hydroquinone + NAD(+) => H(+) + NADH + O2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63050", "l": "H(+) + pravastatin => H2O + pravastatin lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40366", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24809", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37352", "l": "cytidine 2'-phosphate + H2O => cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062122", "l": "histone H3K37 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group to the lysine residue at position 37 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140943", "l": "histone H4K20 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671702", "l": "AP1G2 binds HGS and CHMP2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047219", "l": "monoterpenol beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60205", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38406", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40715", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65447", "l": "butanoyl-CoA + hexan-1-ol <=> CoA + hexyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090684", "l": "contact chemoreceptor activity", "d": ["A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102873", "l": "1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18668", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) <=> (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982617", "l": "CYGB:O2 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016827", "l": "hydrolase activity, acting on acid carbon-phosphorus bonds", "d": ["Catalysis of the hydrolysis of any acid carbon-phosphorus bond."], "t": []}, {"i": "EC:3.11.-.-", "l": "\"Acting on carbon-phosphorus bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18825", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66678", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate => (2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19647", "l": "a D-threo-aldono-1,5-lactone + H(+) + NADH => a D-threo-aldose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32724", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50930", "l": "(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70481", "l": "TPI1 isomerizes GA3P to DHAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030626", "l": "U12 snRNA binding", "d": ["Binding to a U12 small nuclear RNA (U12 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36520", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA => 3-oxooctacosanyol-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22959", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38920", "l": "H2O + sphing-4-enine-phosphocholine => choline + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64439", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) <=> glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632677", "l": "PTCH is internalized (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10708", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glucose", "d": [], "t": []}, {"i": "EC:2.7.7.34", "l": "\"glucose-1-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29760", "l": "octanoate(in) => octanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38314", "l": "carminomycin + S-adenosyl-L-methionine <=> daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69974", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909718", "l": "Formation of p-STAT1 homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23534", "l": "AMP + choloyl-CoA + diphosphate => ATP + cholate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73743", "l": "2 H(+)(out) + serotonin(in) = 2 H(+)(in) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35569", "l": "(9Z,12Z)-octadecadienoate + ethanolamine => H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5246478", "l": "APOM binds retinoids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109857", "l": "MAP2K1 binds MAPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20511", "l": "ADP + H(+) + O-phosphoviomycin => ATP + viomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678854", "l": "S1PR1 binds S1PR1 agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32481", "l": "3,5-diiodo-L-tyrosine + H(+) + 2 NADPH => 2 iodide + L-tyrosine + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49362", "l": "2,2'-dioxospirilloxanthin + H2O => 2',2'-dihydroxy-2-oxospirilloxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35020", "l": "L-threonine(in) => L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901604", "l": "dethiobiotin transmembrane transporter activity", "d": ["Enables the transfer of dethiobiotin from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25742", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033813", "l": "deacetylcephalosporin-C acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14037", "l": "4,5beta-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21811", "l": "2,5-dioxopiperazine + H2O <=> glycylglycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38869", "l": "pseudouridine(516) in 16S rRNA => uridine(516) in 16S rRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70848", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) => L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.73", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47322", "l": "3-oxo-3-phenylpropanoate + L-glutamate => (S)-3-amino-3-phenylpropanoate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473186", "l": "FSTL3 binds Activin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854052", "l": "Formation of the SCF-FBXL7 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40119", "l": "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0099107", "l": "ion channel regulator activity involved in G protein-coupled receptor signaling pathway", "d": ["Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047779", "l": "citrate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39118", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53451", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42334", "l": "ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate => ATP + L-glutamate + oxidized coenzyme F420-2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212614", "l": "Glutamine transport from astrocytes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.672771840408203", "identifiers": [{"i": "GO:0009975", "l": "cyclase activity", "d": ["Catalysis of a ring closure reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61379", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805730", "l": "SETD9 methylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67461", "l": "(R)-malate + A => AH2 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112604", "l": "Phosphorylated STATs are released (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003988", "l": "acetyl-CoA C-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785768", "l": "MRN complex binds DNA double strand breaks (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748991", "l": "XDH oxidises 6MP to 6TU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63808", "l": "ATP + citrate + spermidine = AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73024", "l": "pregnenolone sulfate(out) => pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141367", "l": "Myristoylation of tBID by NMT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71938", "l": "glycocholate(out) + 2 Na(+)(out) <=> glycocholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69074", "l": "Formation of Processive Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44046", "l": "11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45683", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972965", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17029", "l": "(S)-allantoin + H2O = allantoate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.2.5", "l": "\"allantoinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632652", "l": "Hh-Npp binds CDON and PTCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668605", "l": "RAC2:GTP binds NOX2 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375302", "l": "Kinetochore capture of astral microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14835", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH => (R)-mevalonate + CoA + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878237", "l": "RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36062", "l": "A + dihydrourocanate <=> AH2 + urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63078", "l": "2-acetylphloroglucinol + 3 CO2 + 4 CoA => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050199", "l": "piperidine N-piperoyltransferase activity", "d": ["Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668735", "l": "RAC1:GTP binds NOX3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38232", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11502", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20518", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036505", "l": "prosaposin receptor activity", "d": ["Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982617", "l": "CYGB:O2 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17301", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}, {"i": "EC:2.7.11.4", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18183", "l": "(S)-malate + CoA + H(+) => acetyl-CoA + glyoxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39852", "l": "2 a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44594", "l": "2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36080", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25684", "l": "2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73401", "l": "D-aspartate(out) + sulfate(in) => D-aspartate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000120", "l": "CBLIF binds RCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23032", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.3.1", "l": "\"phosphoribosylformylglycinamidine cyclo-ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16216", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51958", "l": "(Z)-2-methylpropanal oxime => (E)-2-methylpropanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956234", "l": "Translation of DCUN1D3 is inhibited by PUM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49224", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785213", "l": "LIPC dimer binds heparin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30548", "l": "(3S)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211959", "l": "CYP3A43 6b-hydroxylates TEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66535", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31504", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate => 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.36", "l": "\"retinal dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42759", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10621", "l": "(E)-cinnamaldehyde + CoA + NADP(+) => (E)-cinnamoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76584", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADH => (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29149", "l": "2 H(+)(out) + H2O + nitrite + ubiquinone-8 => 2 H(+)(in) + nitrate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021068", "l": "PalmS-ESRs bind CAVs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15833", "l": "(S)-4-hydroxymandelate + H(+) + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.19", "l": "\"4-hydroxymandelate oxidase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59510", "l": "S-(2-succinyl)-L-cysteinyl-[protein] => fumarate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507871", "l": "Aquaporins passively transport glycerol out of cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10984", "l": "(S)-lactate + oxaloacetate = (S)-malate + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.99.7", "l": "\"lactate--malate transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75862", "l": "Fall Back to Closed Pre-initiation Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24779", "l": "H2O + pheophorbide a <=> C-13(2)-carboxypyropheophorbide a + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754644", "l": "SARS-CoV-2 E pentamer binds TJP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419351", "l": "PAF receptor binds platelet activating factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984733", "l": "Kinesin-3 is a dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.61", "l": "\"feruloyl-CoA hydratase/lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61659", "l": "(2E,6E)-farnesol + ATP <=> (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69752", "l": "benzylmalonyl-CoA + H(+) + O2 => (E)-cinnamoyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368133", "l": "Expression of RORA (ROR-alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110311", "l": "POLZ extends translesion synthesis (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061473", "l": "murein tripeptide carboxypeptidase activity", "d": ["Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10235", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate <=> 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035275", "l": "dibutyl phthalate binding", "d": ["Binding to dibutyl phthalate, C(16)H(22)O(4)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.55", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204303", "l": "MRE11 binds cytosolic DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37804", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13270", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44133", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40740", "l": "(20S)-ginsenoside Rb2 + 2 H2O => (20S)-ginsenoside C-Y + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45481", "l": "gamma-hexachlorocyclohexane => (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75284", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.188", "l": "\"beta-geranylfarnesene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17525", "l": "biuret + H2O = NH4(+) + urea-1-carboxylate", "d": [], "t": []}, {"i": "EC:3.5.1.84", "l": "\"biuret amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984226", "l": "PLK1 phosphorylates NEK9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10058", "l": "(2E)-butenoyl-CoA + NH4(+) => (3S)-3-aminobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54825", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] => alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72857", "l": "ADP(in) + dADP(out) => ADP(out) + dADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56995", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> (+)-costunolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29539", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.261", "l": "\"dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31051", "l": "(3R)-beta-leucine + H2O + NAD(+) = 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41825", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334827", "l": "SUMO-CRABP2 binds atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617583", "l": "CaMKII autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38790", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29061", "l": "2 H(+)(out) + ubiquinol-8 => 2 H(+)(in) + H2 + ubiquinone-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418845", "l": "Activation of caspase-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54702", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+) => 4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69479", "l": "acetyl-CoA + L-lysine <=> CoA + H(+) + N(6)-acetyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17205", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": [], "t": []}, {"i": "EC:2.8.2.27", "l": "\"quercetin-3-sulfate 4'-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47812", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928604", "l": "SFKs phosphorylate VAV2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58990", "l": "(E)-4-hydroxynon-2-enoate + H(+) + H2O2 => (E)-4-hydroxynon-2-enal + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604712", "l": "Initial activation of proMMP7 by trypsin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666425", "l": "p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604368", "l": "Autocatalytic activation of bound proMMP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43692", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}, {"i": "EC:2.7.11.32", "l": "\"[pyruvate, phosphate dikinase] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38452", "l": "hydrogen sulfide + NADP(+) + n sulfur => NADPH + (n+1) sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31431", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-santalene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.83", "l": "\"beta-santalene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23655", "l": "N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16794", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantetheine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18821", "l": "acetyl-CoA + choline = acetylcholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.6", "l": "\"choline O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24506", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950782", "l": "p-STAT1 binds p-STAT3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174367", "l": "GCL ligates L-Glu to L-Cys (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12778", "l": "2-amino-4-hydroxypteridine + O2 => 2-amino-4,7-dihydroxypteridine + chemical entity", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11534", "l": "glyoxylate + H2O2 + NH4(+) => glycine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67803", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183055", "l": "Binding of CBL to EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72732", "l": "UDP-alpha-D-glucose(in) + UMP(out) => UDP-alpha-D-glucose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389159", "l": "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603784", "l": "PEX19:class I PMP binds PEX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62402", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2S)-ephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27702", "l": "aldehydo-D-galacturonate = keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653957", "l": "Rag dimer formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34965", "l": "Na(+)(out) => Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033154", "l": "ABC-type oligogalacturonide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)."], "t": []}, {"i": "TCDB:3.A.1.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71584", "l": "L-histidine(in) + Na(+)(in) => L-histidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49161", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.480207878732358", "identifiers": [{"i": "GO:0015294", "l": "solute:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63660", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.6.1.121", "l": "\"8-amino-7-oxononanoate carboxylating dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761110", "l": "BHLHE22 homodimer binds intron 1 of CDH11 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027042", "l": "CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31642", "l": "mycinamicin III + S-adenosyl-L-methionine <=> H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11591", "l": "A + H2O + isoquinoline <=> AH2 + isoquinolin-1(2H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64157", "l": "an N-(fatty acyl)-L-methionine + H2O => a fatty acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381727", "l": "RAP1A exchanges GDP for GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.2", "l": "\"exodeoxyribonuclease III\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20132", "l": "AMP + H2O <=> adenine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430347", "l": "MigFilin associates with Filamin and F-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004498", "l": "calcidiol 1-monooxygenase activity", "d": ["Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62256", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182186", "l": "Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693198", "l": "RHOD binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72959", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54585", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62187", "l": "peregrinol diphosphate <=> diphosphate + labd-13(16),14-diene-9-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27544", "l": "4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde => methanol + N,N-dimethyl-4-nitrosoaniline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21800", "l": "all-trans-antheraxanthin + L-ascorbate = all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473184", "l": "Follistatin (FST) binds Activin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56400", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396370", "l": "VTN binds collagens II, III and V (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76970", "l": "a short-chain fatty aldehyde + H2O + NADP(+) <=> a short-chain fatty acid + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41581", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate => 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41865", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH => decanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.34", "l": "\"legumain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70226", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate <=> 2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49378", "l": "12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606349", "l": "Mis18 complex binds the centromere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008607", "l": "phosphorylase kinase regulator activity", "d": ["Modulation of the activity of the enzyme phosphorylase kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45663", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14016", "l": "3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18300", "l": "a phtalamide + H2O <=> a primary amine + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129362", "l": "Fibrillin microfibril assembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700171", "l": "Active ALK phosphorylates PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981606", "l": "Myoglobin binds oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420724", "l": "CASR binds Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981665", "l": "C4b binding protein binds Protein S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161962", "l": "LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14377", "l": "(3R)-3-hydroxy-L-aspartate = glycine + glyoxylate", "d": [], "t": []}, {"i": "EC:4.1.3.14", "l": "\"L-erythro-3-hydroxyaspartate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30900", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052675", "l": "3-methylbutanol:NADP oxidoreductase activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69265", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate => an isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29869", "l": "ADP + IDP => AMP + ITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25704", "l": "H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36590", "l": "an aldopyranose + NADP(+) <=> aldono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40131", "l": "(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.57", "l": "\"heme oxygenase (mycobilin-producing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53445", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657767", "l": "Expression of APOD regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52449", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56435", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15608", "l": "H2O + L-serine O-sulfate <=> H(+) + NH4(+) + pyruvate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67201", "l": "H2O + N-acetyltyramine => acetate + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36535", "l": "docosanoyl-CoA + sphinganine = CoA + H(+) + N-docosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26222", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68914", "l": "DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166538", "l": "The bound receptor dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13120", "l": "O-acetyl-L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11535", "l": "glycine + H2O + O2 <=> glyoxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937989", "l": "RUNX1 binds PRC1 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17178", "l": "(R)-carnitine + octanoyl-CoA => CoA + O-octanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68595", "l": "ORC2 binds ORC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.1", "l": "\"citrate (Si)-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203979", "l": "Coat Assembly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875531", "l": "MET binds TNS4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37365", "l": "5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22419", "l": "3,4-dihydroxybenzoate + H(+) <=> catechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41066", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11662", "l": "acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051990", "l": "(R)-2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374909", "l": "Catabolism of Noradrenaline (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53101", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62712", "l": "betaenone C + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75091", "l": "2 chloride(in) + sulfate(out) = 2 chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418904", "l": "A1 and A3 receptors bind adenosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213201", "l": "Formation of collagen fibres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31671", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.235", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350651", "l": "Caspase-mediated cleavage of MASK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949301", "l": "RORC gene expression is stimulated by RUNX3:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67021", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032551", "l": "pyrimidine ribonucleoside binding", "d": ["Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29832", "l": "Ni(2+)(in) => Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654224", "l": "Activated FGFR3 binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63181", "l": "NADPH + 2 O2 => H(+) + NADP(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59229", "l": "6-sulfo-alpha-D-quinovose => 6-sulfo-beta-D-quinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560804", "l": "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111956", "l": "Calmodulin activates Cam-PDE 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46825", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848776", "l": "PTK6 phosphorylates DOK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40193", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3R)-hydroxyoctanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27426", "l": "(2E,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21441", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 => a long-chain alkane + formate + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936356", "l": "GUCY2C trimer binds sta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299476", "l": "MPP cleaves targeting peptide (presequence) of inner membrane precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046559", "l": "alpha-glucuronidase activity", "d": ["Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835944", "l": "ADAR1 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731141", "l": "Syndecan-1 binds fibronectin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033856", "l": "pyridoxine 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H2O + H+ + phosphate + pyridoxine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848726", "l": "PTK6 phosphorylates BCAR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65762", "l": "a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48221", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA => (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48932", "l": "a ganglioside GT1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57017", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10588", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH = 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34793", "l": "formate + H(+) + hydroxymethylphosphonate => 2-hydroxyethylphosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52957", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30446", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005185", "l": "neurohypophyseal hormone activity", "d": ["The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35352", "l": "NADP(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421835", "l": "trans-Golgi Network Vesicle Scission (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218815", "l": "p-6Y-VEGFR2 binds NCK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63043", "l": "H2O + lovastatin <=> H(+) + lovastatin carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56636", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47113", "l": "chenodeoxycholate + glycine => glycochenodeoxycholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76225", "l": "3',5'-cyclic AMP(out) => 3',5'-cyclic AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57696", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] = adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46919", "l": "H2O + juvenile hormone I <=> H(+) + juvenile hormone I carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36174", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol <=> 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40603", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43128", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.214", "l": "\"tRNA (guanine(10)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0052712", "l": "inositol phosphosphingolipid phospholipase activity", "d": ["Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295613", "l": "SPRY2 binds GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944262", "l": "Association of procollagen type X (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64516", "l": "2-hydroxyethane-1-sulfonate + NAD(+) = H(+) + NADH + sulfoacetaldehyde", "d": [], "t": []}, {"i": "EC:1.1.1.433", "l": "\"sulfoacetaldehyde reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47086", "l": "3-(4-hydroxyphenyl)pyruvate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36257", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32696", "l": "(2E)-geranyl diphosphate => (-)-car-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59298", "l": "an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => an N-acylglycine + 2 L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29536", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.69", "l": "\"SARS coronavirus main proteinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20277", "l": "acetyl-CoA + an N-hydroxyarylamine = an N-acetoxyarylamine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.118", "l": "\"N-hydroxyarylamine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50787", "l": "dodecanal + NADP(+) <=> (2E)-dodecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25799", "l": "2-oxoglutarate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41138", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0005525", "l": "GTP binding", "d": ["Binding to GTP, guanosine triphosphate."], "t": []}, {"i": "REACT:R-HSA-167429", "l": "The receptor:G-protein complex  binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849055", "l": "PTK6 binds ARHGAP35 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32965", "l": "2-oxoglutarate + NH4(+) => 2-oxoglutaramate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033788", "l": "leucoanthocyanidin reductase activity", "d": ["Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47558", "l": "deoxycholate + taurine => H2O + taurodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60104", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32936", "l": "a cardiolipin + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435244", "l": "PECAM1 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41913", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH => hexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60324", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.359", "l": "\"[histone H3]-lysine(36) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57279", "l": "a 2'-deoxyguanosine in DNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73238", "l": "2,6-dichlorobenzoquinone + H2O <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11483", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10892", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211289", "l": "MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19027", "l": "H2O2 + NH4(+) + oxaloacetate => H2O + L-aspartate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0015925", "l": "galactosidase activity", "d": ["Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205262", "l": "Direct recruitment of PI3K to p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193703", "l": "IKKbeta is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354060", "l": "Translocation of RIAM to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2169046", "l": "Degradation of TGF-beta receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44223", "l": "15-hydroxypentadecanoate + ATP + CoA <=> 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163310", "l": "TFAM binds to mitochondrial promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854209", "l": "TBC1D10A binds JFC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201457", "l": "BMP2 binds to the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099620", "l": "UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "d": ["Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65093", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77528", "l": "hexanal + hydrogen cyanide => (2S)-2-hydroxyheptanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18369", "l": "O2 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.21", "l": "\"glycerol-3-phosphate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34104", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48169", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine => N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31855", "l": "(S)-2,3-epoxysqualene = achilleol B", "d": [], "t": []}, {"i": "EC:5.4.99.48", "l": "\"achilleol B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22155", "l": "a ubiquinone + D-glucose <=> a ubiquinol + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40987", "l": "EDTA + 2 FMNH2 + 2 O2 = ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.14.33", "l": "\"ethylenediaminetetraacetate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014610", "l": "Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15800", "l": "bilirubin IXalpha + NAD(+) <=> biliverdin IXalpha + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54939", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH <=> decanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54648", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.173", "l": "\"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29893", "l": "ADP + H(+) + L-histidine(in) + phosphate => ATP + H2O + L-histidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56304", "l": "ATP + H2O + rifampicin = 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:2.7.9.6", "l": "\"rifampicin phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30565", "l": "7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953339", "l": "DNPH1 hydrolyses dGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54726", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668404", "l": "TNFA binds TNFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761474", "l": "AMOT-2 binds CDH11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40053", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805122", "l": "AURKB binds TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64398", "l": "glycyl-sarcosine(in) + H(+)(in) => glycyl-sarcosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42360", "l": "D-allulose = keto-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54528", "l": "aldehydo-D-ribose 5-phosphate = D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36804", "l": "2-hydroxy-2,3-dihydrogenistein => genistein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37260", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) => 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37023", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56389", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052871", "l": "alpha-tocopherol omega-hydroxylase activity", "d": ["Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66879", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15775", "l": "ADP + dihydroxyacetone phosphate + H(+) => ATP + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840564", "l": "OMA1 hydrolyzes YME1L1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10261", "l": "ATP + H2O + Mg(2+)(out) => ADP + H(+) + Mg(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34701", "l": "(-)-alpha-isocomene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51434", "l": "[(1S)-1-acetamidoethyl]phosphonate + CoA => (S)-1-aminoethylphosphonate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17491", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => H(+) + NADH + O2 + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67402", "l": "allo-aromadendrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71848", "l": "glycoursodeoxycholate(out) => glycoursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877281", "l": "PIAS1 binds p-STAT1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373342", "l": "CX3CR1 binds CX3CL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418858", "l": "RhoGTPase GEF's recruited to DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571324", "l": "IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867041", "l": "EGFR phosphorylates EPS15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17093", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}, {"i": "EC:4.6.1.13", "l": "\"phosphatidylinositol diacylglycerol-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13093", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654163", "l": "Activated FGFR4 binds PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54256", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.79", "l": "\"protein-L-histidine (3S)-3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420980", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65967", "l": "ATP + H2O + taurocholate(out) <=> ADP + H(+) + phosphate + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60909", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64535", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008030", "l": "neuronal pentraxin receptor activity", "d": ["Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050583", "l": "hydrogen dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + H2 = NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2219524", "l": "PDPK1 binds PIP2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16988", "l": "3-oxoadipate + NADP(+) <=> H(+) + maleylacetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69771", "l": "a short-chain fatty aldehyde + H2O + NAD(+) = a short-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55040", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.179", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22825", "l": "2'-deoxyuridine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13730", "l": "FAD => AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228406", "l": "tetX HC transports tetX LC from target cell endosome membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53106", "l": "4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 4-hydroxyestrone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18774", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140856", "l": "histone H2AK13 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624800", "l": "CDK1 phosphorylates LBR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40382", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55891", "l": "[aequorin]--dioxetanone <=> [excited state blue fluorescent protein] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483186", "l": "PC is converted to PS by PTDSS1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74803", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62334", "l": "adenosine 3'-diphosphate,5'-diphosphate + AMP => ADP + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12278", "l": "3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => 3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.30", "l": "\"1,3-beta-oligoglucan phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016673", "l": "oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.8.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63062", "l": "2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+) => 5-methylorsellinate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17415", "l": "an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55675", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74378", "l": "H2O2(out) <=> H2O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27422", "l": "(2E,6E)-farnesyl diphosphate => (3E,6E)-alpha-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64055", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37729", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77304", "l": "N(omega),N(omega)-dimethyl-L-arginine + pyruvate => 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58085", "l": "1-(13Z-docosenoyl)-glycerol + H2O => (13Z)-docosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76169", "l": "glycyl-L-leucine + 2 H(+)(in) => glycyl-L-leucine(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16356", "l": "2-oxoglutarate + taurine <=> L-glutamate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019948", "l": "SUMO activating enzyme activity", "d": ["Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851078", "l": "NPM1-ALK-dependent MAPK8,9 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33004", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.4.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654651", "l": "Activated FGFR4 binds FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68003", "l": "1,1-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0017110", "l": "nucleoside diphosphate phosphatase activity", "d": ["Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57345", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033999", "l": "chondroitin B lyase activity", "d": ["Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0016714", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor."], "t": []}, {"i": "EC:1.14.16.-", "l": "\"With reduced pteridine as one donor, and incorporation of one atom of oxygen\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004037", "l": "allantoicase activity", "d": ["Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626938", "l": "Beta-catenin binds SOX proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450088", "l": "GLUT1 tetramer binds 4xATP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69419", "l": "H(+) + H2O2 + thiocyanate <=> H2O + hypothiocyanous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40239", "l": "ATP + CoA + dodecanedioate = AMP + diphosphate + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40001", "l": "a fatty aldehyde + phosphoethanolamine => a sphingoid 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64317", "l": "2 dihydrogeodin + 2 H(+) + O2 => 2 (+)-geodin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071172", "l": "dihydromonapterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56461", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0042803", "l": "protein homodimerization activity", "d": ["Binding to an identical protein to form a homodimer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034011", "l": "L-cysteate sulfo-lyase activity", "d": ["Catalysis of the reaction: L-cysteate + H2O = NH4 + pyruvate + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68946", "l": "H(+) + isoscopoletin + S-adenosyl-L-homocysteine => esculetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56543", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110219", "l": "Cleavage of thymine by TDG glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696274", "l": "RND1 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64762", "l": "ethanethiol + NH4(+) + pyruvate => H2O + S-ethyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168896", "l": "NS1 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010074", "l": "ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40755", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23833", "l": "an N-acyl-D-mannosamine + ATP => ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866277", "l": "AP-2 directly binds some endocytic cargo (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676254", "l": "Formation of the MLL3 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592436", "l": "Initial activation of proMMP9 by MMPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.7.1.-", "l": "\"Forming diazo bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061953", "l": "mRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57465", "l": "(E)-caffeate + UDP-alpha-D-glucose => 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21280", "l": "H2O + 2 O2 + thiamine = H(+) + 2 H2O2 + thiamine acetate", "d": [], "t": []}, {"i": "EC:1.1.3.23", "l": "\"thiamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001566", "l": "non-kinase phorbol ester receptor activity", "d": ["Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50306", "l": "21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55427", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44741", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine => H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52243", "l": "2 H2O + 2 Mn(2+) + O2 <=> 4 H(+) + 2 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322429", "l": "XIAP monoubiquinates TLE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17890", "l": "H2O + phosphoethanolamine => acetaldehyde + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802973", "l": "PLK3 phosphorylates CDC25C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49244", "l": "NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226999", "l": "ADD1:ADD3 binds DMTN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22159", "l": "GDP + H2O <=> GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034003", "l": "vetispiradiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20007", "l": "an alcohol + D-glucuronate => an alpha-D-glucuronoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48193", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835411", "l": "FA core complex:HSP70s binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15046", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) => H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854052", "l": "Formation of the SCF-FBXL7 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75581", "l": "AH2 + cyathin A3 => A + cyathatriol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70815", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) = H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858346", "l": "AMHR2 binds AMH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836500", "l": "IKK complex is activated by PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73274", "l": "rhamnetin + S-adenosyl-L-methionine <=> H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205289", "l": "Autophosphorylation of KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987043", "l": "IL22RA1 binds JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380574", "l": "Dopamine synaptic vesicle docking and priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75984", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) => (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693590", "l": "SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27808", "l": "acetate + acetoacetyl-CoA => acetoacetate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759158", "l": "SQSTM1 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981355", "l": "RASA1 binds RAS:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20006", "l": "an alpha-D-glucuronoside + H2O => an alcohol + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42785", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0102973", "l": "norsolorinate anthrone synthase activity", "d": ["Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10481", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate => 4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62433", "l": "a uridine in tRNA + S-adenosyl-L-methionine => a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64537", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30610", "l": "A + all-trans-phytofluene <=> AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938328", "l": "RUNX1:CBFB binds the NFE2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57380", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.163", "l": "\"(S)-1-hydroxy-N-methylcanadine 13-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296326", "l": "HCAR1 binds LACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689861", "l": "Recruitment of XPA and release of CAK  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75498", "l": "n H(+)(out) + pregnenolone sulfate(out) <=> n H(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71914", "l": "cholate(out) + 2 Na(+)(out) <=> cholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25965", "l": "(R)-benzoin + NADP(+) => benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22015", "l": "precorrin-4 + S-adenosyl-L-methionine <=> precorrin-5 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517674", "l": "p-S158,221-HuR binds mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54310", "l": "H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10417", "l": "fumarate + toluene => 2-benzylsuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47188", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol = hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44371", "l": "Cr(6+) + 2 NADPH + O2 <=> Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15606", "l": "H2O + L-serine O-sulfate => H(+) + NH4(+) + pyruvate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0048256", "l": "flap endonuclease activity", "d": ["Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28889", "l": "H(+)(out) + L-serine(out) => H(+)(in) + L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24418", "l": "4-hydroxybenzoate + formate + 2 H(+) => 2,4'-dihydroxyacetophenone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51374", "l": "CoA + H(+) + N-(9Z-hexadecenoyl)-glycine => (9Z)-hexadecenoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534365", "l": "Slo3 Potassium Transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47524", "l": "cholate + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873921", "l": "Binding of STAT1 to p-IFNGR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036403", "l": "arachidonate 8(S)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67827", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O <=> a lipid X + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28021", "l": "enterobactin + 3 H2O <=> 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046523", "l": "S-methyl-5-thioribose-1-phosphate isomerase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38471", "l": "L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.44", "l": "\"L-histidine N(alpha)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050524", "l": "coenzyme-B sulfoethylthiotransferase activity", "d": ["Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551570", "l": "VANGL2 is phosphorylated in response to WNT5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620975", "l": "MLKL binds PIPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65341", "l": "acetyl-CoA + L-threonyl-[protein] => CoA + O-acetyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706336", "l": "Active FLT3 binds to SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59192", "l": "ATP + eicosanoate + H(+) = diphosphate + icosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25517", "l": "an acyl-CoA + tropine => CoA + H(+) + O-acyltropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102245", "l": "lupan-3beta,20-diol synthase activity", "d": ["Catalysis of the reaction: lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53929", "l": "a tertiary amine + S-adenosyl-L-methionine => a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035599", "l": "aspartic acid methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56920", "l": "a medium chain fatty acid + ATP + H(+) = a medium-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48058", "l": "beta-D-glucosylceramide + D-galactose => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67335", "l": "13-cis-retinal + H2O + NAD(+) <=> 13-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44276", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.65", "l": "\"(d)CTP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202604", "l": "Formation of a heteromeric BMP receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0070679", "l": "inositol 1,4,5 trisphosphate binding", "d": ["Binding to inositol 1,4,5 trisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15683", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46869", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44073", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71450", "l": "D-alanine(in) + Na(+)(in) <=> D-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30112", "l": "Fe(III)-enterobactin + H(+) + 3 H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30449", "l": "formaldehyde + H2O + NAD(+) + xanthine => 3-methylxanthine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433711", "l": "Cis-homodimerization of nectins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018768", "l": "RHOU auto-activates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61942", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389956", "l": "Beta-tubulin:GTP + Cofactor A ->  Beta-tubulin:GTP: Cofactor A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934742", "l": "RUNX1 binds PRMT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395784", "l": "Nascent CMs transform into mature CMs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002056", "l": "cytosine binding", "d": ["Binding to cytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396029", "l": "Latent TGF-beta-3 binds integrins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50412", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] = H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75339", "l": "chloride(out) + nitrate(in) = chloride(in) + nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0050737", "l": "O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17127", "l": "2-oxoglutarate + N-(2-aminobutanoyl)glycine => H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21754", "l": "all-trans-capsorubin => all-trans-violaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53394", "l": "(2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140664", "l": "ATP-dependent DNA damage sensor activity", "d": ["A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72354", "l": "glutarate(in) + glycocholate(out) <=> glutarate(out) + glycocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51395", "l": "(9Z)-octadecenoyl-CoA + serotonin <=> CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35275", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71339", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) = chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654752", "l": "ATF4 binds the PPP1R15A (GADD34) promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.204", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11315", "l": "atrazine + H2O <=> chloride + H(+) + hydroxyatrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47060", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805981", "l": "HMGB1 release from cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624800", "l": "CDK1 phosphorylates LBR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9833777", "l": "PKR binds activating host RNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002466", "l": "Formation of allysine by LOX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336443", "l": "LIN7, CASK and APBA1 bind (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74743", "l": "kaempferol + S-adenosyl-L-methionine = 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22930", "l": "4-aminobutanoyl-CoA + acetate => 4-acetamidobutanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61714", "l": "2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.64", "l": "\"retinoid isomerohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70982", "l": "Fumarate + H2O <=> (S)-Malate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66488", "l": "quillate + UDP-alpha-D-glucose = quillaic acid 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264622", "l": "Cho is acetylated to AcCho by CHAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60235", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31339", "l": "acetate + ATP + holo-[ACP] = acetyl-[ACP] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.35", "l": "\"acetate--[acyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38569", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69827", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.373", "l": "\"alpha-(1->2) branching sucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799350", "l": "Exocytosis of specific granule membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25914", "l": "5-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-5-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.70", "l": "\"aculeacin-A deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27347", "l": "5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+) => FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354073", "l": "Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55551", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63024", "l": "(13Z)-docosenamide + H2O = (13Z)-docosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005149", "l": "interleukin-1 receptor binding", "d": ["Binding to an interleukin-1 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55708", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.60", "l": "\"cysteine-dependent adenosine diphosphate thiazole synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13358", "l": "3-hydroxypropanoate + NAD(+) => 3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202709", "l": "JAM2 dimerises (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015120", "l": "phosphoglycerate transmembrane transporter activity", "d": ["Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.138", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21664", "l": "4-nitrophenyl phosphate + H2O = 4-nitrophenol + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.41", "l": "\"4-nitrophenylphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35116", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA => (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15600", "l": "a Fe(III)-siderophore(out) + ATP + H2O <=> a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20412", "l": "alpha-D-glucose 1-phosphate + riboflavin <=> D-glucose + FMN", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68415", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) <=> 2 H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11613", "l": "H2O + L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74077", "l": "NAD(+) + phylloquinol => H(+) + NADH + phylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60253", "l": "(S)-methylmalonyl-CoA + NADP(+) => acryloyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139906", "l": "Activation of BAD by calcineurin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.17", "l": "\"4-hydroxy-4-methyl-2-oxoglutarate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013963", "l": "RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626928", "l": "CREBBP binds FOXO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27993", "l": "1-deoxy-D-xylulose + ATP <=> 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54558", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate => a 5'-end ribonucleotide-tRNA(His) + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69360", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934742", "l": "RUNX1 binds PRMT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37650", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809764", "l": "SBF1 binds MTMR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018756", "l": "ammeline aminohydrolase activity", "d": ["Catalysis of the reaction: ammeline + H2O = ammelide + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60799", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73541", "l": "dCTP(in) + UTP(out) => dCTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66770", "l": "ADP + coproporphyrin I(out) + H(+) + phosphate => ATP + coproporphyrin I(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944225", "l": "Association of procollagen type XVII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36458", "l": "ATP + H2O + L-alanylglycine(out) <=> ADP + H(+) + L-alanylglycine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46957", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0005234", "l": "extracellularly glutamate-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990311", "l": "type-I cohesin domain binding", "d": ["Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55361", "l": "11-cis-retinol => 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73556", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] => (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53873", "l": "CTP + D-ribose 5-phosphate + H(+) => CDP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042614", "l": "CD70 receptor binding", "d": ["Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198813", "l": "GSTO dimers reduce DeHA to AscH- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833441", "l": "NS1 (1C) binds to IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31795", "l": "(+)-(E)-beta-caryophyllene + H2O = (+)-caryolan-1-ol", "d": [], "t": []}, {"i": "EC:4.2.1.138", "l": "\"(+)-caryolan-1-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75266", "l": "isovitexin + O2 <=> 3'-dehydroisovitexin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23113", "l": "6-methylsalicylate + H(+) => 3-methylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23168", "l": "coformycin + NADP(+) = 8-oxocoformycin + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.235", "l": "\"8-oxocoformycin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29057", "l": "a ubiquinol + 2 H(+)(out) => a ubiquinone + 2 H(+)(in) + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018766", "l": "dihydrophloroglucinol hydrolase activity", "d": ["Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70154", "l": "6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59355", "l": "beta-lactose + O2 <=> H2O2 + lactobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25018", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682983", "l": "ATM phosphorylates WHSC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48507", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49732", "l": "H(+) + O2 + violaceinate = CO2 + H2O + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004912", "l": "interleukin-3 receptor activity", "d": ["Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73995", "l": "geranylgeranyl diphosphate + H2O = (S)-(+)-nephthenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35904", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174119", "l": "Free APC/C phosphorylated by Plk1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15138", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-L-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10969", "l": "a carboxylate + CoA + GTP => an acyl-CoA + GDP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48633", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168767", "l": "JAK2 phosphorylates STAT1/STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72515", "l": "(R)-carnitine(out) + glutarate(in) = (R)-carnitine(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48398", "l": "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72722", "l": "eIF2 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222704", "l": "KatG reduces H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55018", "l": "7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => H(+) + menthone + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34466", "l": "8-hydroxycopalyl diphosphate <=> cis-abienol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112152", "l": "RNA Polymerase III Promoter Opening at Type 3 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070974", "l": "POU domain binding", "d": ["Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12703", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770145", "l": "Formation of the Spliceosomal Bact complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40100", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164515", "l": "Fusogenic activation of gp41 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59290", "l": "D-glucose + sphing-4-enine => beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866277", "l": "AP-2 directly binds some endocytic cargo (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24027", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64138", "l": "(9Z)-octadecenoate + L-asparagine => H2O + N-(9Z-octadecenoyl)-L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019140", "l": "inositol 3-kinase activity", "d": ["Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43889", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine => [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54931", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71708", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) => H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17687", "l": "CO2 + uracil => H(+) + uracil 5-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60033", "l": "8-oxo-GTP + H2O => 8-oxo-GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.6", "l": "\"N-acetyllactosaminide alpha-2,3-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58443", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166015", "l": "Association of LBP with LPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17664", "l": "ATP + CoA + succinate <=> ADP + phosphate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41234", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50254", "l": "a 3-oxoacyl-CoA + CO2 + CoA => an acyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11623", "l": "H2O + L-2-amino-4-chloropent-4-enoate <=> 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49122", "l": "H2O + NADP(+) + violaceinate => H(+) + NADPH + O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "50.595880266536945", "identifiers": [{"i": "GO:0042277", "l": "peptide binding", "d": ["Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55375", "l": "H2O + methyl (-)-jasmonate <=> H(+) + jasmonate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72283", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32339", "l": "(+)-thujan-3-ol + NADP(+) = (+)-thujan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51787", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate <=> deoxyhumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034958", "l": "aminohydroquinone monooxygenase activity", "d": ["Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63065", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + tetraacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30609", "l": "AH2 + all-trans-zeta-carotene => A + all-trans-phytofluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58785", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28516", "l": "(R)-carnitinyl-CoA + AMP + diphosphate => (R)-carnitine + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72711", "l": "cathenamine + H(+) = 4,21-dehydrogeissoschizine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201629", "l": "Caspase-mediated cleavage of Tau (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49249", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] => galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34881", "l": "4-methoxy-4-oxo-3-phenylbutanoate + NH4(+) => 2 H2O + methyl 3-cyano-2-phenylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72305", "l": "L-glutamate(out) + L-thyroxine(in) => L-glutamate(in) + L-thyroxine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724290", "l": "GNRHR2 binds GNRH1,2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59956", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate = a nitrile + sulfate + sulfur", "d": [], "t": []}, {"i": "EC:4.8.1.5", "l": "\"thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27991", "l": "1-deoxy-D-xylulose + ATP => 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38440", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16483", "l": "3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine => 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14814", "l": "L-2-aminohexano-6-lactam => D-2-aminohexano-6-lactam", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60559", "l": "uridine(35) in tRNA(Tyr) <=> pseudouridine(35) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10182", "l": "(6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH => (6R)-10-formyltetrahydrofolate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65929", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71072", "l": "L-arginine(in) + L-cysteine(out) => L-arginine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61448", "l": "H(+) + NADPH + O2 + tigecycline = 11a-hydroxytigecycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692880", "l": "HRH3 binds Hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-445072", "l": "Interaction of PAK1 with Rac1-GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805035", "l": "TP53 binds STK11 and NUAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849428", "l": "PTPN1 binds PTK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31999", "l": "(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.100", "l": "\"bicyclogermacrene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49386", "l": "(12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140842", "l": "n fibrin monomers -> fibrin multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067667", "l": "IL6 binds IL6R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45557", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28233", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050343", "l": "trans-2-enoyl-CoA reductase (NAD+) activity", "d": ["Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.392", "l": "\"3-O-beta-D-glucopyranosyl-beta-D-glucuronide phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.87", "l": "\"ADAMTS13 endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42124", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24504", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.54", "l": "\"acireductone dioxygenase (Fe(2+)-requiring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75658", "l": "(9Z)-octadecenoate + O2 <=> (8R)-hydroperoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449855", "l": "IL10 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41335", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35100", "l": "fusidate(in) + H(+)(out) => fusidate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694427", "l": "MIA3 binds procollagen VII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29137", "l": "a menaquinone + 2 H(+)(out) + H2O + nitrite => a menaquinol + 2 H(+)(in) + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27927", "l": "UMP(in) => UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50926", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428609", "l": "Type I Na+-coupled phosphate co-transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54018", "l": "(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17510", "l": "H2O + thiamine => 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62964", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.245794426288597", "identifiers": [{"i": "GO:0008081", "l": "phosphoric diester hydrolase activity", "d": ["Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71841", "l": "dehydroepiandrosterone 3-sulfate(in) => dehydroepiandrosterone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11564", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = alpha-D-glucose 1-phosphate + D-gluconate", "d": [], "t": []}, {"i": "EC:2.4.1.321", "l": "\"cellobionic acid phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726621", "l": "PGR binds PGR antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114264", "l": "Translocation of activated BAX to the mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179421", "l": "Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72172", "l": "2 Na(+)(out) + taurohyocholate(out) => 2 Na(+)(in) + taurohyocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47149", "l": "a ubiquinone + caffeine + H2O => 1,3,7-trimethylurate + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709454", "l": "EPOR binds EPOR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26019", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.79", "l": "\"mannosylfructose-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61238", "l": "4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-methionine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74965", "l": "L-leucine(in) + L-ornithine(out) + Na(+)(in) => L-leucine(out) + L-ornithine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036470", "l": "tyrosine 3-monooxygenase activator activity", "d": ["Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53673", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31976", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16977", "l": "acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.5", "l": "\"2-oxopropyl-CoM reductase (carboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62610", "l": "S-sulfanylglutathione + ubiquinol-10 => glutathione + H(+) + hydrogen sulfide + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74520", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O => beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73718", "l": "UBF-1 Binds rDNA Promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1364044", "l": "PRLR:JAK2 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686790", "l": "ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28648", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate => 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034838", "l": "menthone dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102525", "l": "2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity", "d": ["Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64228", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28450", "l": "N(6)-(D-psicosyl)-L-lysine(in) = N(6)-(D-psicosyl)-L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36367", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O = 2-hydroxyglutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45181", "l": "2 (E)-4-coumaroyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372719", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76954", "l": "H2O + N-methyl-2-methylpropanamine + NAD(+) <=> 2-methylpropanal + H(+) + methylamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32009", "l": "diphosphate + isopimara-8(14),15-diene => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17754", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58704", "l": "rifampicin hemiaminal = rifampicin ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38199", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20015", "l": "H(+) + N-carbamoyl-L-aspartate + phosphate => carbamoyl phosphate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72814", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11819", "l": "alpha-D-glucose 6-phosphate <=> beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34248", "l": "1-deoxymethyl-sphinganine + NADP(+) => 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015578", "l": "mannose transmembrane transporter activity", "d": ["Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832665", "l": "HNF1B binds the HNF4A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13315", "l": "formaldehyde + glycine + H2O2 => H2O + O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663156", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77110", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450494", "l": "HuR binds mRNAs in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202307", "l": "Change of PKC theta conformation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63519", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 <=> biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444523", "l": "Formation of MSH1:PMS2 Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674531", "l": "AAMP binds EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784959", "l": "BPHL hydrolyses VACV to ACV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.58", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA => a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35855", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30472", "l": "(2Z,6Z)-farnesyl diphosphate => (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689544", "l": "UCHL5 binds INO80 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60118", "l": "CO2 + hydroxymethylphosphonate + succinate => 2-oxoglutarate + methylphosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307803", "l": "TIMM22 inserts proteins into inner membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26196", "l": "(S)-malate + ATP + CoA <=> (S)-malyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67724", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) = CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000010", "l": "trans-hexaprenyltranstransferase activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.19", "l": "\"steroid 17alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378956", "l": "Luteinizing hormone is a heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38631", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390886", "l": "HRH4 binds Hist (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868622", "l": "Glucose is transferred from UDP-glucose onto glucose-6-phosphate (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71608", "l": "(S)-malate(in) + phosphate(out) => (S)-malate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928578", "l": "EPH receptors autophosphorylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984733", "l": "Kinesin-3 is a dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617972", "l": "FOXO3 binds SOD2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70082", "l": "2-oxoglutarate + clavatol + O2 <=> CO2 + hydroxyclavatol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69422", "l": "H2O + hypoiodite => H2O2 + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848339", "l": "PNPLA5 hydrolyzes TAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65793", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174235", "l": "Association of Emi1 with Cdc20 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.49", "l": "\"separase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62885", "l": "O2 + 4 semiviriditoxin => 2 (M)-viriditoxin + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030379", "l": "neurotensin receptor activity, non-G protein-coupled", "d": ["Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30621", "l": "2 AH2 + all-trans-lycopene => 2 A + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55975", "l": "acetyl-CoA + ethanol <=> CoA + ethyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63136", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.26", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696267", "l": "RND3 binds GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732527", "l": "FFAR1 binds rosiglitazone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13008", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine <=> H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59167", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42076", "l": "2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22564", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29219", "l": "a menaquinone + sn-glycerol 3-phosphate = a menaquinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45851", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) <=> 3-oxododecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425923", "l": "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52522", "l": "20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380782", "l": "STAT binds to the active receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63558", "l": "dynorphin A-(1-12) + L-lysine => dynorphin A-(1-13) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0062156", "l": "mitochondrial ATP-gated potassium channel activity", "d": ["Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66639", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (-)-alpha-acorenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102983", "l": "xylogalacturonan beta-1,3-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan = UDP + 4 H+ + a xylogalacturonan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211206", "l": "Translocation of DFF to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50389", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64946", "l": "dCMP + 2 H(+) + 2 phosphate => dCTP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26155", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil <=> 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60287", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70698", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) <=> chloride(in) + glycine(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951499", "l": "Loading of antigenic peptides on to class I MHC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54476", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31804", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32235", "l": "(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903794", "l": "cortisol binding", "d": ["Binding to cortisol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381644", "l": "ER calcium channels open in response to activated PKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76003", "l": "glutarate(in) + xanthurenate(out) = glutarate(out) + xanthurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21366", "l": "2 6-aminohexanoate => H2O + N-(6-aminohexanoyl)-6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48103", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990882", "l": "CDK1 phosphorylates NUP98 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74891", "l": "CO2(out) = CO2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875816", "l": "STAT3 binds activated MET receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43396", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420265", "l": "AMY1-3 bind IAPP(34-70) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30076", "l": "CMP + H2O => cytosine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31607", "l": "rhodopin = all-trans-lycopene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004038", "l": "allantoinase activity", "d": ["Catalysis of the reaction: allantoin + H2O = allantoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14246", "l": "ATP + H2O => AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34122", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676268", "l": "Formation of the MLL4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43968", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163320", "l": "Association of mTERF with the termination sequence (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41252", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65239", "l": "3-methylbutanol + acetyl-CoA <=> 3-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56211", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59832", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.171", "l": "\"protein-fructosamine 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211301", "l": "PDX1-dependent synthesis of IAPP protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18532", "l": "3-methylbutanol + NAD(+) <=> 3-methylbutanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62556", "l": "3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638222", "l": "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620663", "l": "EGR1 binds the VGF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218820", "l": "Src kinases phosphorylate VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74046", "l": "L-alanine(in) + L-methionine(out) <=> L-alanine(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50415", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] <=> H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209163", "l": "CI transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102897", "l": "abietadienal hydroxylase activity", "d": ["Catalysis of the reaction: abietal + NADPH + O2 = abietate + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66003", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018579", "l": "protocatechuate 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77358", "l": "2-oxobutanoate + L-alanine <=> (2S)-2-aminobutanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32247", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46451", "l": "2 L-tyrosyl-tRNA(Tyr) <=> cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23099", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43830", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51565", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937419", "l": "CBR3 reduces DOX to DOXOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989776", "l": "Expression of APOA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49255", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047459", "l": "3-aminobutyryl-CoA ammonia-lyase activity", "d": ["Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40085", "l": "26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33957", "l": "DIBOA beta-D-glucoside + H(+) + UDP => DIBOA + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19663", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-mannitol 1-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170159", "l": "Translocation of Cdc25 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674385", "l": "p-T,Y MAPKs dimerize (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47736", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66829", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798044", "l": "BTG2 binds CCR4-NOT complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12560", "l": "hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.218", "l": "\"hydroquinone glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047418", "l": "phthalyl amidase activity", "d": ["Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40871", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) = (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090683", "l": "GPCR sweet taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of sweet taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20562", "l": "3-hydroxypyruvate + H(+) => CO2 + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22900", "l": "(R)-acetoin + NAD(+) = diacetyl + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.303", "l": "\"diacetyl reductase [(R)-acetoin forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.1", "l": "\"P-type phospholipid transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029454", "l": "Autophosphorylation of PAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.156", "l": "\"adenosylcobinamide kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.122", "l": "\"(S)-tetrahydroprotoberberine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48516", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.39", "l": "\"actinomycin lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847968", "l": "PTEN binds FRK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66579", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol <=> 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209903", "l": "Noradrenaline is converted to adrenaline (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53409", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56250", "l": "2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein] => 1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16610", "l": "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13634", "l": "ATP + L-glutamate + putrescine => ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018837", "l": "2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33054", "l": "choline + NAD(+) <=> betaine aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55511", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23854", "l": "cis,cis-muconate + 2 H(+) => catechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20040", "l": "D-sorbitol 6-phosphate + NADP(+) <=> aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46548", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": [], "t": []}, {"i": "EC:1.14.19.19", "l": "\"sphingolipid 10-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23688", "l": "adenine + H(+) + H2O = hypoxanthine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.2", "l": "\"adenine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66180", "l": "ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin-glucuronoside(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378956", "l": "Luteinizing hormone is a heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050286", "l": "sorbitol-6-phosphatase activity", "d": ["Catalysis of the reaction: D-glucitol 6-phosphate + H2O = D-glucitol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2152276", "l": "Secretion of transmembrane collagens (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67838", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74754", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol <=> holo-[polyketide synthase] + prefumagillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382055", "l": "Grb7 binds to the active PDGF receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31720", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047745", "l": "chlorogenate hydrolase activity", "d": ["Catalysis of the reaction: chlorogenate + H2O = (-)-quinate + cis-caffeate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76328", "l": "L-aspartate(in) + L-phenylalanine(out) => L-aspartate(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16864", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine <=> (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65442", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033847", "l": "O-phosphoserine sulfhydrylase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160874", "l": "HYAL1 hydrolyses (HA)50 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373717", "l": "DCC interacts with DIP13alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50107", "l": "taurine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106615", "l": "Removal of siRNA passenger strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50353", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH => 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003877", "l": "ATP adenylyltransferase activity", "d": ["Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22502", "l": "(E)-feruloylacetyl-CoA + CO2 + CoA => (E)-feruloyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26250", "l": "H(+) + levopimaradienol + NADPH + O2 => 2 H2O + levopimaradienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14189", "l": "D-tryptophan + O2 = N-formyl-D-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16743", "l": "a 1,2-diacylglycerol + CoA => a 2-acylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810724", "l": "PI3 binds the bacterial surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69538", "l": "ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => alpha-D-tagatopyranose 1-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655284", "l": "Activated FGFR4 mutants phosphorylate FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785607", "l": "FANCM binds FAAP24 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53424", "l": "a fatty acyl-CoA + a sphingoid base = an N-acyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983152", "l": "Transfer of ubiquitin from E1 to E2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0120020", "l": "cholesterol transfer activity", "d": ["Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868071", "l": "Clathrin recruits PIK3C2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65187", "l": "2-oxoglutarate + O2 + preaustinoid A1 <=> berkeleyone B + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444523", "l": "Formation of MSH1:PMS2 Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61154", "l": "CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39280", "l": "ATP + dodecanoate(out) + H2O => ADP + dodecanoate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995334", "l": "COX15 transforms heme O to heme A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.168", "l": "\"2-dehydropantolactone reductase (Re-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66021", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46171", "l": "ATP + CoA + pentanoate <=> AMP + diphosphate + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19643", "l": "(E)-4-coumaroyl-CoA + AMP + diphosphate => (E)-4-coumarate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65755", "l": "2-oxoglutarate + L-glutamate + O2 <=> (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76767", "l": "emodin + S-adenosyl-L-methionine = physcion + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66924", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA = [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755304", "l": "MUL1 ubiquitinates UBXN7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10681", "l": "L-proline => D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73521", "l": "dUTP(in) + UTP(out) => dUTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68927", "l": "ATP + H(+) + hexanoate + NADPH <=> AMP + diphosphate + hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400219", "l": "Beta-TrCP1 binds phosphorylated PER proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48017", "l": "4-methyl-5-nitrocatechol + NADH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74896", "l": "nitric oxide(out) => nitric oxide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43879", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA <=> 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008890", "l": "glycine C-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14535", "l": "creatine => creatinine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16005", "l": "galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.42", "l": "\"galactarate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34087", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol = a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10966", "l": "ADP + D-xylulose 5-phosphate + H(+) => ATP + D-xylulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19931", "l": "[(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102608", "l": "tetracenomycin B3 8-O-methyl transferase activity", "d": ["Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine = tetracenomycin E + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52463", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799350", "l": "Exocytosis of specific granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173626", "l": "Activation of C1r (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21245", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine => an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34895", "l": "ATP + H2O + selenite(out) = ADP + H(+) + phosphate + selenite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66265", "l": "ATP + H(+) + nonanoate => diphosphate + nonanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21222", "l": "4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050311", "l": "sulfite reductase (ferredoxin) activity", "d": ["Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928656", "l": "gamma-secretase cleaves EPHB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47072", "l": "1-eicosanoylglycerol + H2O = eicosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39240", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH => NADP(+) + triacontanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41061", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109858", "l": "MAP2K2 binds MAPK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55285", "l": "all-trans-retinol + tetradecanoyl-CoA => all-trans-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62059", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047653", "l": "allantoin racemase activity", "d": ["Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888589", "l": "Release of GABA at the synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72696", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) => UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218805", "l": "PKC autophosphorylates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047816", "l": "D-arabinose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6804100", "l": "HMGB1 binds LPS (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24330", "l": "10-formyldihydrofolate + ADP + phosphate => 7,8-dihydrofolate + ATP + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71249", "l": "beta-alanine(in) + chloride(in) + 2 Na(+)(in) => beta-alanine(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0098640", "l": "integrin binding involved in cell-matrix adhesion", "d": ["Any integrin binding that occurs as part of the process of cell-matrix adhesion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64844", "l": "(2E)-geraniol + benzoyl-CoA = (2E)-geranyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14833", "l": "(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.88", "l": "\"hydroxymethylglutaryl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177942", "l": "EGFR binds EGF ligand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20746", "l": "15-oxoprostaglandin D2 + H(+) + NADPH => NADP(+) + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46256", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56355", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55977", "l": "glutathione + thiosulfate => H(+) + S-sulfanylglutathione + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24787", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74723", "l": "Endosome acidification (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49913", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19355", "l": "cholate + glycine => glycocholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56279", "l": "ATP + L-proline <=> 3'-L-prolyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63144", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)-tetracosenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51295", "l": "a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53817", "l": "hydrogen sulfide + O-succinyl-L-serine => L-cysteine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669024", "l": "CD70 binds CD27 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692738", "l": "HRH2 binds HRH2 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21540", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.24", "l": "\"phosphoribosylanthranilate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64939", "l": "dGTP + H2O <=> dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56159", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990714", "l": "hydroxyproline O-galactosyltransferase activity", "d": ["Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218805", "l": "PKC autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627056", "l": "Procaspase 9 forms dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67793", "l": "ribonucleotidyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66442", "l": "but-3-en-2-one + H(+) + NADPH => butan-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25848", "l": "(1S,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182988", "l": "Sprouty lures CBL away from EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20558", "l": "2 H(+) + H2O + urea => CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58490", "l": "H2O + NAD(+) + succinate semialdehyde + trimethylamine => 4-(trimethylamino)butanoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73091", "l": "AMP(out) + FMN(in) = AMP(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66897", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75177", "l": "dADP + H(+) + NADP(+) => dATP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036317", "l": "tyrosyl-RNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57681", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15549", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.109", "l": "\"methylthioribulose 1-phosphate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66395", "l": "ATP + H2O + prostaglandin E1(in) <=> ADP + H(+) + phosphate + prostaglandin E1(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75220", "l": "H2O + L-fucono-1,5-lactone => H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46267", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10185", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O => 3-oxoadipate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15199", "l": "an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004671", "l": "protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42788", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.186", "l": "\"23S rRNA (cytidine(2498)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28112", "l": "5'-chloro-5'-deoxyadenosine + L-methionine => chloride + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75438", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56658", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43961", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632677", "l": "PTCH is internalized (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57610", "l": "3-chlorocatechol + H(+) + NADH => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20860", "l": "(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.223", "l": "\"isopiperitenol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858270", "l": "HILPDA binds lipid droplets (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018794", "l": "RHOV binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17359", "l": "H2O2 + R'C(R)S-S(R)CR' => O2 + 2 R'C(R)SH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2169046", "l": "Degradation of TGF-beta receptor complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156910", "l": "Formation of eEF1B complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67184", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine = (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49247", "l": "NAD(+) + resolvin E1 <=> 18-oxo-resolvin E1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54554", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48162", "l": "epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52428", "l": "12-oxo-leukotriene B4 + H(+) + NADH = 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592232", "l": "Expression of TFB1M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47515", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717193", "l": "GNB1,3:GNG13 binds PLCB2:Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17207", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21599", "l": "L-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22940", "l": "ATP + L-arginine = ADP + H(+) + N(omega)-phospho-L-arginine", "d": [], "t": []}, {"i": "EC:2.7.3.3", "l": "\"arginine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45177", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33048", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429441", "l": "SYK activation by SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37214", "l": "2',3'-cyclophospho-GMP + H2O <=> guanosine 2'-monophosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015054", "l": "gastrin receptor activity", "d": ["Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706298", "l": "Active FLT3 binds to CSK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203479", "l": "STAB2 (FEEL-2) binds ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32083", "l": "CTP + pseudaminate = CMP-pseudaminate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.81", "l": "\"pseudaminic acid cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29660", "l": "O-acetyl-L-serine(in) => O-acetyl-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37754", "l": "2-methyl-trans-aconitate <=> 2-methyl-cis-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50332", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374667", "l": "DCC interaction with SIAH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005128", "l": "erythropoietin receptor binding", "d": ["Binding to an erythropoietin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0005034", "l": "osmosensor activity", "d": ["Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853745", "l": "RET binds GFRA1,GFRA3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63603", "l": "H2O + neocasomorphin <=> L-isoleucine + neocasomorphin-(1-5)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36335", "l": "D-glucuronate + H2O + NAD(+) = D-glucarate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55477", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54096", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47696", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51760", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451347", "l": "Activation of JNK by DSCAM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45687", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) <=> N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430311", "l": "Rsu-1 interacts with Pinch1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426489", "l": "RISC binds inexactly matching target RNAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708408", "l": "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55482", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19200", "l": "adenosine 5'-phosphosulfate + NH4(+) <=> adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27666", "l": "(R)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50155", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1006169", "l": "Factor H binds host cell surface markers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874078", "l": "PTK2 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43510", "l": "2-(dihydroxymethyl)-5-formylfuran => 2,5-diformylfuran + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683635", "l": "E pentamer is transported to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75380", "l": "H2O + L-canavanine => L-homoserine + N-hydroxyguanidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730882", "l": "Phosphorylation of PKC-theta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42171", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047618", "l": "acylagmatine amidase activity", "d": ["Catalysis of the reaction: N(4)-benzoylagmatine + H2O = agmatine + benzoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64783", "l": "S-benzyl-L-cysteine <=> 2-aminoprop-2-enoate + benzylthiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102003", "l": "Delta8-sphingolipid desaturase activity", "d": ["Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor = 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37810", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74332", "l": "O-butanoyl-(R)-carnitine(in) => O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49266", "l": "(E)-caffeate + H(+) + shikimate => 5-O-[(E)-caffeoyl]-shikimate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40058", "l": "1,2,3-trioctanoylglycerol + H2O <=> 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56592", "l": "a disubstituted aliphatic (S)-hydroxynitrile = a ketone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74542", "l": "creatinine(in) <=> creatinine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34276", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine => 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.50", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73481", "l": "D-histidine(out) + H(+)(out) + L-ornithine(in) => D-histidine(in) + H(+)(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35393", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53542", "l": "(13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097253", "l": "beta-hydroxybutyrate transmembrane transporter activity", "d": ["Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730902", "l": "Oligomerization of p-CARMA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49318", "l": "(5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218832", "l": "CDC42:GTP binds PAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619430", "l": "PPM1E dephosphorylates CAMK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49983", "l": "H2O + hexanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44924", "l": "2-oxoadipate + acetyl-CoA + H2O = (R)-dihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686318", "l": "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44072", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57076", "l": "3-oxoisoapionate 4-phosphate + H2O = (2R)-3-phosphoglycerate + glycolate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.28", "l": "\"3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35734", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873918", "l": "Transphosphorylation of JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11830", "l": "a 3'-end 2'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47007", "l": "H2O + O-phospho-L-threonyl-[protein] <=> L-threonyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73670", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine <=> (E,E)-piperlonguminine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70942", "l": "L-methionine(in) <=> L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.21", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9621179", "l": "Cinaciguat binds sGC:NO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32414", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27693", "l": "ATP + dGDP <=> ADP + dGTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712085", "l": "ALK mutants phosphorylate STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102362", "l": "esculetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose = 3-O-beta-D-glucosyl-esculetin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985485", "l": "RUNX2 and RB1 bind the BGLAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55100", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66543", "l": "7-dehydrocholesterol + A + H2O <=> AH2 + cholesta-5,7-dien-3beta,25-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77116", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49500", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.97", "l": "\"methyltetrahydroprotoberberine 14-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41657", "l": "dihydrosanguinarine + NADP(+) => NADPH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636560", "l": "Eis acetylates DUSP16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20451", "l": "5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+) => 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44972", "l": "(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28526", "l": "(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388900", "l": "Neurotensin receptors can bind neurotensins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33589", "l": "CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694367", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082391", "l": "Trimerization of HSF1 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018448", "l": "hydroxymethylmethylsilanediol oxidase activity", "d": ["Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134914", "l": "Beta-catenin migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54587", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13842", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) => Fe(III)2-[transferrin] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54623", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 <=> 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44640", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17817", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005123", "l": "death receptor binding", "d": ["Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31815", "l": "(2E,6E)-farnesyl diphosphate = (+)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.89", "l": "\"(+)-beta-caryophyllene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076371", "l": "GLCE epimerises more GlcA to IdoA as sulfate content rises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451856", "l": "FT is phosphorylated by DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27762", "l": "CTP + H2O = CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612509", "l": "SGK phosphorylates SRF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64369", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134954", "l": "DHX9 binds DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862300", "l": "LYZ binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788628", "l": "p-Y-STATs dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24636", "l": "H2 + NAD(+) = H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30386", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-7-epi-alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55644", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] = ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806974", "l": "MET dimers autophosphorylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008043", "l": "MAPK8 phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48043", "l": "a globoside Gb4Cer + H2O <=> a globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0001228", "l": "DNA-binding transcription activator activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0031369", "l": "translation initiation factor binding", "d": ["Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976768", "l": "Factor H binds to C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14879", "l": "ADP + L-glutamyl 5-phosphate => ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70596", "l": "GOT2 dimer deaminates L-Asp (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-901047", "l": "Binding of ERp57 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24956", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate = (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694555", "l": "Protein M localizes to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66214", "l": "asc-omegaDeltaC5-CoA + H2O2 => asc-omegaC5-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24547", "l": "H2O + L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69325", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008433", "l": "RUNX2 binds CDKN1A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873926", "l": "IFNG dimer binds IFNGR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65019", "l": "chlorothalonil + H2O <=> 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42258", "l": "3-oxooctanoyl-[ACP] + CO2 + CoA => H(+) + hexanoyl-CoA + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046715", "l": "active borate transmembrane transporter activity", "d": ["Enables the transport of borate across a membrane against the concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801101", "l": "RABGGTA binds RABGGTB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65230", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871265", "l": "YAP1 binds TEAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018712", "l": "3-hydroxybutyryl-CoA thiolase activity", "d": ["Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.71", "l": "\"phosphatidyl-N-methylethanolamine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0016867", "l": "intramolecular acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from one position to another within a single molecule."], "t": []}, {"i": "EC:5.4.1.-", "l": "\"Transferring acyl groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41439", "l": "(9Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (9Z-octadecenoate) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22734", "l": "4-methylphenol + CO2 => 4-hydroxyphenylacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873946", "l": "OTUD3 deubiquitinates PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76300", "l": "L-aspartate(in) + L-cystine(out) => L-aspartate(out) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43522", "l": "2,5-dicarboxyfuran + H(+) + H2O2 => 2-carboxy-5-(dihydroxymethyl)furan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166015", "l": "Association of LBP with LPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849857", "l": "KLK5 cleaves and activates CELA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877192", "l": "RUNX1 binds FOXP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14705", "l": "2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.14", "l": "\"CoA-disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39250", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA <=> (2E,11Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68178", "l": "CO2 + dainate A + H2O + succinate => 2-oxoglutarate + N-geranyl-L-glutamate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30995", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19868", "l": "4 H(+) + uroporphyrinogen III <=> 4 CO2 + coproporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015625", "l": "ABC-type ferric hydroxamate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109862", "l": "MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51386", "l": "CoA + H(+) + N-hexadecanoyl-serotonin => hexadecanoyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705467", "l": "SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11225", "l": "ATP + 2 D-alanine => ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51168", "l": "(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15746", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose => [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75612", "l": "H2O + plasmodiophorol A => plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29228", "l": "H(+)(in) + indole(in) => H(+)(out) + indole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48857", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55214", "l": "formyl-CoA + pentadecanal => (2R)-hydroxyhexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76029", "l": "(S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate => (S)-reticuline + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28040", "l": "[thioredoxin]-dithiol + CDP => [thioredoxin]-disulfide + dCDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0016753", "l": "O-sinapoyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24574", "l": "[(1->4)-alpha-D-glucosyl](n+1) + D-fructose => [(1->4)-alpha-D-glucosyl](n) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53304", "l": "AH2 + 2 ATP + 2 cob(II)alamin = A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429157", "l": "ABCC4 accumulation of dense granule contents (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73235", "l": "2,6-dichlorobenzoquinone + H2O = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106239", "l": "9,13-epoxylabda-14-ene synthase activity", "d": ["Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211164", "l": "AKT phosphorylates FOXO1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43467", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0140313", "l": "molecular sequestering activity", "d": ["Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}, {"i": "REACT:R-HSA-3245898", "l": "TCN1 binds correnoids in the circulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034930", "l": "1-hydroxypyrene sulfotransferase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33164", "l": "beta-nicotinamide D-riboside(in) => beta-nicotinamide D-riboside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29650", "l": "alpha-maltopentaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981931", "l": "RAC1 and CDC42 activate PAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928607", "l": "p-EPHs bind VAV2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47785", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33100", "l": "acetyl-CoA + spermine => CoA + H(+) + N(1)-acetylspermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75883", "l": "NAD(+) = ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295613", "l": "SPRY2 binds GRB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35890", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10508", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620456", "l": "sGC stimulators bind sGC:NO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76329", "l": "L-aspartate(out) + L-phenylalanine(in) => L-aspartate(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080099", "l": "L-methionine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909720", "l": "IFN alpha/beta binds to IFNAR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58677", "l": "NADPH + O2 + rifamycin SV => H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60519", "l": "L-tryptophan <=> D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28320", "l": "scutellarin + UDP => scutellarein + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62160", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49845", "l": "(-)-dehydrodiconiferyl acid + a quinone => (-)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74773", "l": "3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine => 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602466", "l": "Activation of MT-MMPs by FURIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64702", "l": "acetophenone + H(+) + NADH => 1-phenylethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008925", "l": "maltose O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662669", "l": "Dopaquinone transforms to Leucodopachrome (Cyclodopa) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54659", "l": "linalool <=> (2E)-geraniol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046998", "l": "(S)-usnate reductase activity", "d": ["Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD+ = (S)-usnate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70118", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46087", "l": "H2O + sn-glycerol 1-phosphate <=> glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11758", "l": "AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein] => ATP + biotin + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14541", "l": "choloyl-CoA + H2O = cholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74897", "l": "nitric oxide(in) => nitric oxide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0140807", "l": "NAD+-protein-glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005167", "l": "neurotrophin TRK receptor binding", "d": ["Binding to a neurotrophin TRK receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37514", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72049", "l": "AH2 + fusahexin + 6 H2O => A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046480", "l": "galactolipid galactosyltransferase activity", "d": ["Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66049", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848726", "l": "PTK6 phosphorylates BCAR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917696", "l": "Cargo Sequestration (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57618", "l": "dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase] => dihydro-ML-236C-[compactin nonaketide synthase] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641134", "l": "SMURF2 binds AXIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15132", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15568", "l": "an N-acyl-L-amino acid + H2O <=> a carboxylate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782943", "l": "UV-DDB ubiquitinates XPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391168", "l": "SIRP gamma binds CD47 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749215", "l": "MCM8 binds CDC6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66122", "l": "(2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate => 2-oxobutanoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34097", "l": "CO2 + spermidine => carboxyspermidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.3.-", "l": "\"Hydron translocation linked to the hydrolysis of diphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22375", "l": "H2O + O2 + propionate 3-nitronate <=> 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730885", "l": "Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25772", "l": "2-oxoglutarate + L-asparagine + O2 = (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.39", "l": "\"L-asparagine oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39651", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.21", "l": "\"6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11103", "l": "4-hydroxyhexan-3-one <=> 2 propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483089", "l": "PE is converted to PS by PTDSS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28768", "l": "ethylnitronate + O2 => acetaldehyde + chemical entity + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22167", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53363", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(47) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75469", "l": "ethanolamine(in) + n H(+)(out) => ethanolamine(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693609", "l": "ATM phosphorylates TP53 at S15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750666", "l": "ALB binds ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659674", "l": "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11330", "l": "diphosphate + neryl diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106231", "l": "protein-propionyllysine depropionylase activity", "d": ["Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD+ = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:23500", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951966", "l": "EP300 acetylates RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0003964", "l": "RNA-directed DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42722", "l": "2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2552) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58566", "l": "15alpha-stemmadenine intermediate II + 2 H(+) + NADPH => 15alpha-stemmadenine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57913", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) => H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54035", "l": "(6R)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21268", "l": "(R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.31", "l": "\"berberine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437118", "l": "GPVI stimulates PI3K beta, gamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730858", "l": "Autophosphorylation of BTK/ITK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761166", "l": "Expression of LHX1 in intermediate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24375", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] <=> H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54012", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44047", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34743", "l": "15-methylhexadecasphinganine 1-phosphate = 13-methyltetradecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008795", "l": "NAD+ synthase activity", "d": ["Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37801", "l": "2 H2O + 2 NAD(+) => 2 H(+) + 2 NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41023", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790454", "l": "SUMOylation of XPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64843", "l": "2-phenylethanol + benzoyl-CoA <=> CoA + phenethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848939", "l": "PTK6 binds KHDRBS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29464", "l": "K(+)(in) => K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602473", "l": "Autocatalytic activation of MMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29568", "l": "2 chloride(in) + H(+)(out) => 2 chloride(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39916", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33784", "l": "1(F)-beta-D-fructosylsucrose + sucrose => 1,6-kestotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018572", "l": "3,5-dichlorocatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192315", "l": "Bile salts are translocated from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33837", "l": "(4R)-hydroxysphinganine + hexacosanoate => H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733203", "l": "FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009541", "l": "ESR1 binds to TFF1 gene promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227698", "l": "NLRX1 inhibits IPS1 signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52094", "l": "(9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33458", "l": "4alpha-carboxyzymosterol + NADP(+) <=> CO2 + NADPH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186780", "l": "PI3-kinase binds to the active receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014294", "l": "RAC2 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54913", "l": "11-cis-retinol + NADP(+) => 11-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.50", "l": "\"C-glycoside oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49377", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140901", "l": "L-asparagine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-asparagine(out) + Na+(out) = L-asparagine(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60959", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875591", "l": "DOCK7 activates RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59594", "l": "ADP + beta-alanyl-L-arginine + H(+) + phosphate => ATP + beta-alanine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1250280", "l": "ROS oxidize thioredoxin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56295", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047068", "l": "N5,N10-methenyltetrahydromethanopterin hydrogenase activity", "d": ["Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218804", "l": "p38 MAPK activation by VEGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58614", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-octanoylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74930", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] <=> (2E)-butenoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.56", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654569", "l": "Activated FGFR1 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879907", "l": "Tyrosine kinases phosphorylate the receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64853", "l": "benzoyl-CoA + octan-1-ol => CoA + octyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36704", "l": "(2S,5S)-5-carboxymethylproline + ATP => (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654748", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48824", "l": "GDP-beta-L-fucose + Lc4Cer = a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381608", "l": "cAMP activates EPAC2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823816", "l": "OPTN binds CASP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56719", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] <=> H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13280", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate <=> [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55416", "l": "biochanin A + UDP-alpha-D-glucose = biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64092", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61900", "l": "AH2 + betaenone C = A + betaenone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849646", "l": "SPINK5(490-624) binds KLK5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58431", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) <=> (E,E)-2,4-hexadienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714481", "l": "RAC2 binds effectors at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64074", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O => acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.5", "l": "\"prolyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29642", "l": "D-maltohexaose + H2O <=> alpha-D-glucose + D-maltopentaose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682992", "l": "KDM4A,B bind H4K20Me2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804527", "l": "INTL1 binds bacterial glycans (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55054", "l": "CoA + H(+) + pentanoate => H2O + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419428", "l": "S1PR2-5 bind S1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49998", "l": "(25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035529", "l": "NADH pyrophosphatase activity", "d": ["Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56277", "l": "ATP + L-proline => 3'-L-prolyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76114", "l": "4-methylumbelliferone beta-D-glucuronate + H2O <=> 4-methylumbelliferone + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74986", "l": "Elongation of pre-rRNA transcript (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32974", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29821", "l": "ADP + H(+) + L-isoleucine(in) + phosphate => ATP + H2O + L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429529", "l": "Thrombin binding to GP1b:IX:V (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69262", "l": "(3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51460", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate = (9Z)-octadecenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49114", "l": "5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine => phenazine-1-carboxylate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62679", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide <=> 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25222", "l": "H(+) + L-cysteate => CO2 + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.141", "l": "\"4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034818", "l": "ADD 9alpha-hydroxylase activity", "d": ["Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72631", "l": "Formation of the cap-binding eIF4F complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33966", "l": "ATP + isopentenyl phosphate <=> ADP + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110307", "l": "REV1 binds AP-dsDNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451508", "l": "Nuclear translocation of phospho ERK2 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15402", "l": "a dolichyl phosphate + UDP-alpha-D-glucose => a dolichyl beta-D-glucosyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625426", "l": "Retrograde IFT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112703", "l": "PTPN11 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44272", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19631", "l": "2-oxoglutarate + CO2 + NADPH => D-threo-isocitrate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45328", "l": "7,8-dihydroneopterin = 7,8-dihydromonapterin", "d": [], "t": []}, {"i": "EC:5.1.99.8", "l": "\"7,8-dihydroneopterin epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21266", "l": "AH2 + glyoxylate => A + glycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65432", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64392", "l": "a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0170021", "l": "ionotropic taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a soluble compound has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58652", "l": "rifamycin SV ortho-naphthoquinone carboxamide = rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39229", "l": "NADP(+) + octacosanoyl-CoA => (2E)-octacosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70697", "l": "chloride(in) + glycine(in) + 3 Na(+)(in) => chloride(out) + glycine(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63734", "l": "UDP + zolarsartan O-beta-D-glucuronoside => UDP-alpha-D-glucuronate + zolasartan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46976", "l": "(S)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72379", "l": "chloride(out) + iodide(in) = chloride(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30776", "l": "H2O + O2 + pyridoxamine => H2O2 + NH4(+) + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15051", "l": "D-glucose + GDP + H(+) => GDP-alpha-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23567", "l": "2 columbamine + O2 <=> 2 berberine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67296", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001859", "l": "complement component C3dg receptor activity", "d": ["Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990889", "l": "H4K20me3 modified histone binding", "d": ["Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59093", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose => [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30740", "l": "1D-myo-inositol 3-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65735", "l": "2-oxoglutarate + heptyl sulfate + O2 <=> CO2 + H(+) + heptanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55031", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine <=> an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72405", "l": "2-oxoglutarate(in) + urate(out) => 2-oxoglutarate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32871", "l": "a 2-acylglycerol + H2O = a carboxylate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68177", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 => CO2 + dainate A + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429101", "l": "HMIT co-transports myo-inositol with a proton (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48875", "l": "a gentamycin + GTP <=> a gentamycin 2''-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670874", "l": "FIXa variant:FVIIIa does not convert FX to the active FXa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047692", "l": "ATP deaminase activity", "d": ["Catalysis of the reaction: ATP + H2O = ITP + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42450", "l": "(2E)-glutaconyl-CoA + H2O => (R)-2-hydroxyglutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645694", "l": "p14ARF binds C1QBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56655", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77081", "l": "Formation of the CE:GMP intermediate complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37991", "l": "delta-tocopherol + S-adenosyl-L-methionine = beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27296", "l": "6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n) => D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69021", "l": "L-aspartate + NADPH + O2 => H2O + N-hydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15457", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) = catechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186798", "l": "GAP binds to PDGF-beta receptors only (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695949", "l": "SPHK2 phosphorylates sphingoid (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67983", "l": "beta-zeacarotene <=> 7,8-dihydro-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48866", "l": "FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42988", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cembrene C + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.148", "l": "\"cembrene C synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050340", "l": "thymidylate 5'-phosphatase activity", "d": ["Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000342", "l": "RNA cap 4 binding", "d": ["Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49833", "l": "a fatty aldehyde + H2O + NAD(+) => a fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64462", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate => acetyl phosphate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0008752", "l": "FMN reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697043", "l": "Protease binds protease inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759158", "l": "SQSTM1 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41515", "l": "L-ornithine + NADH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10495", "l": "H2O + phosphocholine <=> choline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43792", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.287", "l": "\"25S rRNA (adenine(645)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070089", "l": "chloride-activated potassium channel activity", "d": ["Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009378", "l": "Estrogen-responsive CCND1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141671", "l": "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71783", "l": "MDH2 reduces OA to MAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004901", "l": "granulocyte macrophage colony-stimulating factor receptor activity", "d": ["Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694447", "l": "mRNA2 is translated to Spike (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10554", "l": "2-dehydro-D-glucose + H2O2 => D-glucose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.173931203323974", "identifiers": [{"i": "GO:0061731", "l": "ribonucleoside-diphosphate reductase activity", "d": ["Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990400", "l": "mitochondrial ribosomal large subunit rRNA binding", "d": ["Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799350", "l": "Exocytosis of specific granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005537", "l": "mannose binding", "d": ["Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans."], "t": []}, {"i": "REACT:R-HSA-947991", "l": "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48178", "l": "(2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein] => decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18206", "l": "AH2 + O2 + progesterone => 11alpha-hydroxyprogesterone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44246", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46242", "l": "a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15825", "l": "AZD1979 + H2O = AZD1979 oxetane hydrolysis product + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607058", "l": "Activated protein C:PROCR binds F2R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74169", "l": "formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine => H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21413", "l": "NAD(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45846", "l": "3-oxooctanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696960", "l": "USP49 deubiquitinates H2B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47660", "l": "acetyl-CoA + L-methionine sulfoximine = CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389762", "l": "Phosphorylation of PD-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24188", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.60", "l": "\"dibenzothiophene dihydrodiol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0017113", "l": "dihydropyrimidine dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9840564", "l": "OMA1 hydrolyzes YME1L1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56918", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-androstan-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48488", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21427", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47956", "l": "3-maleylpyruvate + H2O = H(+) + maleate + pyruvate", "d": [], "t": []}, {"i": "EC:3.7.1.23", "l": "\"maleylpyruvate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835385", "l": "DUS2 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42614", "l": "a plastoquinol + n H(+)(out) + NADP(+) => a plastoquinone + (n+1) H(+)(in) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53422", "l": "H(+) + roseoflavin + S-adenosyl-L-homocysteine => 8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70495", "l": "D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48528", "l": "a ganglioside GP1c (d18:1(4E)) + H2O = a ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59543", "l": "(2R)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67124", "l": "a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432897", "l": "ILK interacts with beta-1 integrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392834", "l": "Activation of EPACs by cAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28433", "l": "D-allose 6-phosphate <=> D-allulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23222", "l": "4-chlorobenzoyl-CoA + AMP + diphosphate => 4-chlorobenzoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249378", "l": "STING recruits TBK1 and STAT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564179", "l": "Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27589", "l": "L-tryptophan + pyruvate <=> indole-3-pyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64927", "l": "dATP + 2 H2O <=> dAMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39482", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418872", "l": "Phosphorylation of FADK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847880", "l": "CYTH proteins bind ARF1:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57882", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51898", "l": "acetate + spermine => H2O + N(1)-acetylspermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40066", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71313", "l": "chloride(in) + L-alanine(in) + 2 Na(+)(in) => chloride(out) + L-alanine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432143", "l": "PECAM-1 binds PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64518", "l": "H(+) + NADH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16506", "l": "chorismate => 4-hydroxybenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168880", "l": "vRNP Export through the nuclear pore (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65877", "l": "5alpha-androst-1-ene-3,17-dione + H2O => 1-hydroxy-5alpha-androstan-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0015464", "l": "acetylcholine receptor activity", "d": ["Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14135", "l": "16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17077", "l": "H2O + N,N-dimethylglycine + O2 = formaldehyde + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38772", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831034", "l": "Expression of PAX2 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35259", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62297", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) => (+)-malbrancheamide + 2 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036061", "l": "Defective GLB1 does not hydrolyse linker chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72438", "l": "(E)-caffeoyl-AMP + CoA <=> (E)-caffeoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33579", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate = H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": [], "t": []}, {"i": "EC:1.1.1.335", "l": "\"UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682026", "l": "MRN bound to shortened telomeres activates ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448951", "l": "Activation of p38 alpha/beta MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052911", "l": "23S rRNA (guanine(745)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67462", "l": "AH2 + oxaloacetate => (R)-malate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18818", "l": "acetyl-CoA + malonate => acetate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47498", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH => lithocholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701064", "l": "TRPV1 binds TRPV1 agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31395", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) = all-trans-4,4'-diapophytofluene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59282", "l": "D-asparagine => L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35221", "l": "8-oxo-dAMP + H(+) + phosphate => 8-oxo-dADP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53871", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate <=> 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55687", "l": "chorismate + NH4(+) <=> 4-amino-4-deoxychorismate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33926", "l": "(1R,4R)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47619", "l": "ethionamide + H(+) + NADPH + O2 <=> ethionamide S-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43775", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62527", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796059", "l": "AcK-NFE2L2 binds the BCL2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31442", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-longipinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74734", "l": "Re-integration of insulin receptor into plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.007505823603481", "identifiers": [{"i": "GO:0019887", "l": "protein kinase regulator activity", "d": ["Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32464", "l": "glycine + 2 S-adenosyl-L-methionine => 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928597", "l": "EPH:EFN dimers tetramerise (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68320", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O = 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57574", "l": "7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614461", "l": "Tetramerization of procollagen VI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939204", "l": "ESTG binds ESR1:chaperone complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48229", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709406", "l": "CO binds to Cytochrome c oxidase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24612", "l": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052684", "l": "L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity", "d": ["Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794523", "l": "SLC22A1 transports Cipro into renal cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5144542", "l": "CLOCK acetylates lysine-15 of histone H3, H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64993", "l": "acetyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24960", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 = [excited state blue fluorescent protein] + CO2", "d": [], "t": []}, {"i": "EC:1.13.12.24", "l": "\"calcium-regulated photoprotein\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43798", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46176", "l": "2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003879", "l": "ATP phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247497", "l": "ERBB3 binds neuregulins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22896", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.86", "l": "\"fatty-acyl-CoA synthase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0048038", "l": "quinone binding", "d": ["Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209160", "l": "Activated ERKs phosphorylate ERF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168888", "l": "Alpha1-Microglobulin binds heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49411", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate <=> [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005335", "l": "serotonin:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12355", "l": "L-gulono-1,4-lactone + O2 <=> H2O2 + L-xylo-hex-3-ulonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36348", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine => 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46867", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20441", "l": "L-cysteine + O2 = 3-sulfino-L-alanine + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.20", "l": "\"cysteine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70558", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50953", "l": "7-chloro-L-tryptophan + AH2 + O2 => A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42979", "l": "L-tryptophan <=> 2-aminoprop-2-enoate + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24467", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate <=> D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44312", "l": "1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34601", "l": "3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH => 15-methylhexadecasphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12042", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADPH => (S)-3-(imidazol-5-yl)lactate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018647", "l": "phenanthrene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56824", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 = A + cyclooctatin + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.62", "l": "\"cyclooctatin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42199", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59128", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP = 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.3.2.55", "l": "\"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72671", "l": "eIF5B:GTP is hydrolyzed and released (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29475", "l": "(2E,6E)-farnesyl diphosphate = (+)-cubenene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.63", "l": "\"(+)-cubenene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564169", "l": "Collagen type VIII degradation by MMP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103041", "l": "thiosulfate-thioredoxin sulfurtransferase activity", "d": ["Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59498", "l": "(20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009817", "l": "Acitretin binds to RAR:RXR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010736", "l": "serum response element binding", "d": ["Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18109", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.42", "l": "\"geranylgeranylglycerol-phosphate geranylgeranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21105", "l": "AH2 + cholesterol + O2 => 25-hydroxycholesterol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38524", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50916", "l": "a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166119", "l": "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55000", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23115", "l": "6-methylsalicylate + H(+) <=> 3-methylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46044", "l": "(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011748", "l": "IL9R binds JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22019", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) <=> arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380272", "l": "Plk1-mediated phosphorylation of Nlp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615348", "l": "AGT(34-41) binds to AGTR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433454", "l": "Phosphorylation of GAB2 by SFKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029268", "l": "Phosphorylation and activation of PLCG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052796", "l": "exo-alpha-(2->8)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163691", "l": "Phosphorylation of ChREBP at Serine 556 by AMPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39127", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46318", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+) => GDP-N,N'-diacetylbacillosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202722", "l": "CD48 binds CD244 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134962", "l": "DHX36 binds DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163416", "l": "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.16", "l": "\"formyl-CoA transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41181", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018571", "l": "2,3-dihydroxy-p-cumate dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018459", "l": "carveol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,5R)-carveol + NADP+ = (R)-carvone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39481", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43665", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA => 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17465", "l": "H2O + quercitrin = L-rhamnopyranose + quercetin", "d": [], "t": []}, {"i": "EC:3.2.1.40", "l": "\"alpha-L-rhamnosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75359", "l": "L-mimosine = 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012084", "l": "Constitutive dimerization of FGFR3 cysteine mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71196", "l": "H(+)(out) + Zn(2+)(out) => H(+)(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27696", "l": "(S)-3-methyl-2-oxopentanoate + H2O => (2R,3R)-2,3-dihydroxy-3-methylpentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202604", "l": "Formation of a heteromeric BMP receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40522", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0099604", "l": "ligand-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42520", "l": "uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.22", "l": "\"23S rRNA pseudouridine(2605) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189406", "l": "4 PBGs bind to form HMB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014456", "l": "GDIs block activation of RHOG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624272", "l": "MMPs cleave HB-EGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10122", "l": "inosine in double-stranded RNA + NH4(+) => adenosine in double-stranded RNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72716", "l": "(R)-dihydrolipoate + ATP + H(+) => diphosphate + N(6)-[(R)-dihydrolipoyl]-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48678", "l": "20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55419", "l": "biochanin A + UDP-alpha-D-glucose <=> biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52208", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65478", "l": "CoA + propyl butanoate => 1-propanol + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856951", "l": "PP2A demethylation by PPME1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592371", "l": "Initial activation of proMMP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635102", "l": "GPR161 is internalized (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15018", "l": "a phosphate monoester + H2O => an alcohol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69242", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => glucoraphanin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62996", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74081", "l": "menaquinol-4 + NAD(+) => H(+) + menaquinone-4 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64550", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP] => N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174097", "l": "Association of Emi1 with Cdh1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54434", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45384", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831908", "l": "GREM1 binds BMP4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004468", "l": "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "d": ["Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35981", "l": "diphosphate + fumitremorgin A => dimethylallyl diphosphate + verruculogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65629", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36042", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299338", "l": "Activation of TRESK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46175", "l": "ATP + butanoate + CoA <=> AMP + butanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52579", "l": "hexanoyl-CoA + NAD(+) <=> (2E)-hexenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0062186", "l": "anandamide epoxidase activity", "d": ["Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445071", "l": "Reinsertion of L1 into the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451418", "l": "Pellino ubiquitinates IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879322", "l": "mycothione is reduced to mycothiol (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42838", "l": "5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+) => acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40397", "l": "H2O2 + NAD(+) => 1,2-dihydro-beta-NAD + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71823", "l": "3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36903", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.290", "l": "\"tRNA(Phe) [7-(3-amino-3-carboxypropyl)wyosine(37)-O]-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30479", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785594", "l": "FANCD2 binds FANCI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18760", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> CO2 + cylindrospermopsin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58978", "l": "3-oxopropanoate + H(+) + H2O2 => H2O + malonaldehyde + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65264", "l": "3-hydroxypentacecilide A + A = AH2 + chrodrimanin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047454", "l": "phaseollidin hydratase activity", "d": ["Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17244", "l": "an alpha-amino acid ester + H2O <=> an alcohol + an alpha-amino acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19394", "l": "L-lysine + pyruvate => (S)-2-amino-6-oxohexanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791235", "l": "GADD45A binds AURKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63497", "l": "4-nitrobenzaldehyde + H(+) + NADPH => 4-nitrobenzyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56803", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide <=> cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004394", "l": "heparan sulfate 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate."], "t": []}, {"i": "REACT:R-HSA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72190", "l": "H(+)(out) + sucrose(out) <=> H(+)(in) + sucrose(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28857", "l": "H(+)(out) + melibiose(out) => H(+)(in) + melibiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11014", "l": "L-tryptophan + NH4(+) => H2O + L-tryptophanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45239", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.17", "l": "\"non-specific polyamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44942", "l": "1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62029", "l": "H2O + stigmasteryl 3-beta-D-glucoside => D-glucose + stigmasterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67067", "l": "AH2 + asnovolin K <=> A + asnovolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865244", "l": "TFAP2A homodimer binds CDKN1A (p21) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45456", "l": "H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51788", "l": "2-hydroxybenzoyl-5'-AMP + CoA = 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69515", "l": "H2O + N-acetyl-D-galactosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374672", "l": "Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15682", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58271", "l": "[protein]-C-terminal glycine + NAD(+) <=> [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36120", "l": "gibberellin A9 + S-adenosyl-L-methionine => O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31775", "l": "all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49396", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67941", "l": "2-hydroxyoctanoate + O2 => 2-oxooctanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39232", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH => (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71068", "l": "L-arginine(in) + L-phenylalanine(out) => L-arginine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618093", "l": "ATP hydrolysis by HSP90 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68601", "l": "(2S)-3-sulfopropanediol => 3-oxopropane-1-sulfonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033980", "l": "phosphonopyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72445", "l": "(E)-feruloyl-CoA + AMP + H(+) => (E)-feruloyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59303", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin <=> adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772441", "l": "sFRP binds WNT3A and inhibits WNT:FZD binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58852", "l": "(6E)-8-oxogeraniol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49798", "l": "a fatty acid + glycine => an N-(fatty acyl)-glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20937", "l": "2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60774", "l": "3 CO2 + gibberellin A9 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36625", "l": "(3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine => 3-phenylpyruvate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46931", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375138", "l": "CDO binds BOC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390649", "l": "CHRM1,3,5 bind acetylcholine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34061", "l": "didehydroagroclavine + H(+) + NADPH => agroclavine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24447", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167415", "l": "G-protein alpha subunit is inactivated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68774", "l": "diphosphate + germacrene C => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68787", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + gamma-curcumene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73013", "l": "L-leucine(out) => L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66915", "l": "avenanthramide C + S-adenosyl-L-methionine <=> avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45367", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine <=> (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052758", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity", "d": ["Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31757", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde => 2-oxepin-2(3H)-ylideneacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48539", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O <=> 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9844955", "l": "CLN3 transports GalCer to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603784", "l": "PEX19:class I PMP binds PEX3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836702", "l": "PKR inhibitors bind PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44495", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810937", "l": "Lamellar bodies bind the early cornified envelope (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11841", "l": "benzaldehyde + H2O + NAD(+) => benzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44270", "l": "4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54473", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13664", "l": "H2O + N-formimidoyl-L-aspartate <=> N-formyl-L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679044", "l": "FKBP1A binds sirolimus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483186", "l": "PC is converted to PS by PTDSS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450466", "l": "AUF1:mRNA complex is destroyed (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.921857375477728", "identifiers": [{"i": "GO:0016725", "l": "oxidoreductase activity, acting on CH or CH2 groups", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.17.-.-", "l": "\"Acting on CH or CH2 groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047397", "l": "dolichylphosphate-glucose phosphodiesterase activity", "d": ["Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66365", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O => 6-methyl-3,7-dioxodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0120015", "l": "sterol transfer activity", "d": ["Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637605", "l": "PstS1 binds MRC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14830", "l": "hydrogen sulfide + O-acetyl-L-serine => acetate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21789", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112342", "l": "Inactivation of MAP2K1 by CDK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018798", "l": "RHOV binds GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432897", "l": "ILK interacts with beta-1 integrin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28486", "l": "Fe(2+)(in) = Fe(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42721", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA => 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29402", "l": "H2O + ITP <=> diphosphate + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61291", "l": "5-deoxy-D-ribose + ATP <=> 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641229", "l": "TLE oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54008", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64667", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44027", "l": "(3R)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73266", "l": "genkwanin + S-adenosyl-L-methionine <=> apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67264", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74255", "l": "H2O + L-homoseryl-tRNA(Ser) = H(+) + L-homoserine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19628", "l": "L-threonine <=> acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050194", "l": "phosphonoacetaldehyde hydrolase activity", "d": ["Catalysis of the reaction: H2O + phosphonoacetaldehyde = acetaldehyde + H+ + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37152", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350598", "l": "Arginine<=>Agmatine+CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34894", "l": "selenite(in) <=> selenite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109639", "l": "Formation of the closed pre-initiation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63865", "l": "O2 + octadecanoate => (2R)-2-hydroperoxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114683", "l": "Phosphorylation of Platelet Sec-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622415", "l": "RIP2 binds NEMO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.364", "l": "\"dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66348", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A = (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9828175", "l": "Formation of the NSL complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202222", "l": "Phosphorylation of PKC theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265177", "l": "Exocyst complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609921", "l": "SGTA binds Tail-anchored protein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60439", "l": "3-methylbutyl acetate + H2O <=> 3-methylbutanol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76830", "l": "butylamine + H2O + NAD(+) <=> butanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.737538670852089", "identifiers": [{"i": "GO:0003676", "l": "nucleic acid binding", "d": ["Binding to a nucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10466", "l": "n acetate + chitosan => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062062", "l": "oligosaccharyltransferase complex binding", "d": ["Binding to an oligosaccharyltransferase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32251", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0030971", "l": "receptor tyrosine kinase binding", "d": ["Binding to a receptor that possesses protein tyrosine kinase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.599657566792573", "identifiers": [{"i": "GO:0060590", "l": "ATPase regulator activity", "d": ["Binds to and modulates the activity of an ATP hydrolysis activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53679", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14205", "l": "carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.22", "l": "\"carnosine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689111", "l": "PARK2 autoubiquitinates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683964", "l": "ATM phosphorylates EYA1-4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50289", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74812", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.6", "l": "\"DNA-directed RNA polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37543", "l": "2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde", "d": [], "t": []}, {"i": "EC:1.13.11.76", "l": "\"2-amino-5-chlorophenol 1,6-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47606", "l": "a ganglioside GP1calpha (d18:1(4E)) + CMP + H(+) => a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047502", "l": "(+)-sabinol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (1S,5S)-sabinone + H+ + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61927", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O <=> (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46684", "l": "3-oxochol-4-en-24-oyl-CoA + A = (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717841", "l": "holo-FDPS dimer binds NBPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68066", "l": "a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16753", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 = 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37871", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.182", "l": "\"2-heptyl-3-hydroxy-4(1H)-quinolone synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25482", "l": "acetoacetyl-CoA + succinate => acetoacetate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67908", "l": "a primary linear alkyl sulfate ester + H2O = a primary alcohol + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.21", "l": "\"linear primary-alkylsulfatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35183", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031703", "l": "type 2 angiotensin receptor binding", "d": ["Binding to a type 2 angiotensin receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57284", "l": "a guanosine in RNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54845", "l": "H(+) + hexan-3-one + NADPH + O2 => ethyl butanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39523", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA = (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653957", "l": "Rag dimer formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70986", "l": "glycine(out) + n H(+)(in) <=> glycine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51199", "l": "chloride(out) + Na(+)(out) + serotonin(out) <=> chloride(in) + Na(+)(in) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050388", "l": "uronate dehydrogenase activity", "d": ["Catalysis of the reaction: D-galacturonate + H2O + NAD+ = galactarate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27556", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392513", "l": "Rap1 signal termination by Rap1GAPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30991", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48715", "l": "2 Fe(2+) + 2 H(+) + H2O2 <=> 2 Fe(3+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31016", "l": "H(+) + indole-3-carboxylate => CO2 + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388605", "l": "POMC(138-176) binds MC2R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51118", "l": "H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine => guanosine(6) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40302", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51980", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17083", "l": "(E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine => (E)-isoeugenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62355", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421222", "l": "inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634669", "l": "IMPACT binds GCN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77694", "l": "a ganglioside GD1b (d18:1(4E)) + GDP-beta-L-fucose <=> a ganglioside Fuc-GD1b (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16857", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.113", "l": "\"site-specific DNA-methyltransferase (cytosine-N(4)-specific)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60330", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.35", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68528", "l": "(2E,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51292", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14826", "l": "(1R,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52603", "l": "L-methionine + propanoyl-CoA <=> CoA + H(+) + N-propanoyl-L-methioninate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68559", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58826", "l": "aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51831", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62716", "l": "stemphyloxin I = stemphyloxin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195251", "l": "Assembly of the destruction complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869683", "l": "oxPL binds LBP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863471", "l": "LDLR is bound by DAB2 and ARH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867041", "l": "EGFR phosphorylates EPS15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68447", "l": "5-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196753", "l": "2xPPCS ligates PPanK with Cys (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22834", "l": "N-formyl-L-glutamate + NH4(+) => H2O + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60888", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18510", "l": "H(+) + H2O2 + NADH => 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429860", "l": "DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16512", "l": "H(+) + oxalate <=> CO2 + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69617", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39323", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36799", "l": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49371", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) <=> 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37601", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997706", "l": "MDM2 SUMOylates TP53 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102158", "l": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21467", "l": "2 H(+) + H2O + thiocyanate <=> carbonyl sulfide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662891", "l": "pheomelanin formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18615", "l": "4-hydroxybenzoate + A + formaldehyde + H2O => 4-methoxybenzoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865182", "l": "OTUD7A hydrolyses K11diUb (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36248", "l": "(E)-anol + S-adenosyl-L-methionine => (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14417", "l": "acetyl phosphate + L-lysine = H(+) + N(6)-acetyl-L-lysine + phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.32", "l": "\"lysine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33523", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O = acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64916", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25436", "l": "(2E,6E)-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.38", "l": "\"alpha-bisabolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140761", "l": "sequestered tissue factor -> tissue factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42543", "l": "uridine(13) in tRNA <=> pseudouridine(13) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855195", "l": "I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804879", "l": "MDM2 ubiquitinates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13413", "l": "ADP + thymidine = AMP + dTMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.118", "l": "\"ADP--thymidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432295", "l": "GPVI binds Fyn and Lyn (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57241", "l": "glyoxal + GMP => N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69239", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 4-hydroxybutylnitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46391", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38708", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624120", "l": "CEBPA binds CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "45.836685054912607", "identifiers": [{"i": "GO:0015267", "l": "channel activity", "d": ["Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785711", "l": "Telomere shortening during replicative exhaustion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68279", "l": "butanoyl-CoA + L-seryl-[protein] <=> CoA + O-butanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13560", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + glutathione + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451900", "l": "IL2RB binds JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008942", "l": "nitrite reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: NH4+ + 3 NAD(P)+ + 2 H2O = nitrite + 3 NAD(P)H + 5 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36836", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375140", "l": "CDO binds promyogenic cadherins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42784", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.184", "l": "\"23S rRNA (adenine(2085)-N(6))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68079", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29436", "l": "enterobactin(in) + H(+)(out) => enterobactin(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28390", "l": "N(6)-(D-psicosyl)-L-lysine = N(6)-(D-fructosyl)-L-lysine", "d": [], "t": []}, {"i": "EC:5.1.3.41", "l": "\"fructoselysine 3-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110213", "l": "NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857328", "l": "RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341072", "l": "SUMOylation of RARA with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55622", "l": "a carotenoid beta-end derivative => a carotenoid psi-end group", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40921", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9769235", "l": "MAGED1 binds NPAS4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19654", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23310", "l": "2-O-[(E)-sinapoyl]-D-glucarate + CoA => (E)-sinapoyl-CoA + D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2219524", "l": "PDPK1 binds PIP2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60373", "l": "D-fructose(out) => D-fructose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63217", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411373", "l": "NLK translocates to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43125", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.475256590178944", "identifiers": [{"i": "GO:0005342", "l": "organic acid transmembrane transporter activity", "d": ["Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350745", "l": "Release of Calumenin  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666001", "l": "Profilin:G-actin binds MKL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694527", "l": "Loss of SAR1B GTPase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76908", "l": "(1S)-2-methyl-cyclohexylamine + H2O + NADP(+) => 2-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824196", "l": "HES7 binds the LFNG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39279", "l": "ATP + dodecanoate(out) + H2O = ADP + dodecanoate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53427", "l": "a fatty acyl-CoA + a sphingoid base <=> an N-acyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28035", "l": "[thioredoxin]-disulfide + dADP + H2O => [thioredoxin]-dithiol + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21720", "l": "formamide = H2O + hydrogen cyanide", "d": [], "t": []}, {"i": "EC:4.2.1.66", "l": "\"cyanide hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18981", "l": "(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186780", "l": "Degradation of Ub-SMAD7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685605", "l": "SLAMF7 binds SLAMF7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134954", "l": "DHX9 binds DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67313", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52691", "l": "3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56971", "l": "dCTP + pyruvate <=> dCDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362549", "l": "Hh-Np traffics to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0015131", "l": "oxaloacetate transmembrane transporter activity", "d": ["Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25734", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65766", "l": "(2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005458", "l": "GDP-mannose transmembrane transporter activity", "d": ["Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351948", "l": "Mitochondrial recruitment of Drp1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0016503", "l": "pheromone receptor activity", "d": ["Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015565", "l": "threonine efflux transmembrane transporter activity", "d": ["Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane."], "t": []}, {"i": "RHEA:35019", "l": "L-threonine(in) = L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015505", "l": "uracil:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018798", "l": "RHOV binds GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611851", "l": "ADRB2 bind ADR,NAd (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65642", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine => (4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169394", "l": "ISGylation of IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70481", "l": "TPI1 isomerizes GA3P to DHAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58402", "l": "H(+) + heptanal + NADPH => heptan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015515", "l": "citrate:succinate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44259", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52380", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16480", "l": "NAD(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30902", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34790", "l": "a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987043", "l": "IL22RA1 binds JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102776", "l": "UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76785", "l": "1,9-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75016", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35009", "l": "D-fucose(out) => D-fucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15231", "l": "diphosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57273", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52270", "l": "(1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44590", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17522", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) => ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39072", "l": "dodecanedioyl-CoA + O2 => (2E)-dodecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62524", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429441", "l": "SYK activation by SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28625", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol => (-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77231", "l": "cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + H2O = (S)-2-hydroxypropylphosphonate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624112", "l": "CEBPA binds CDK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173740", "l": "Factor B binds to C3(H2O) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016677", "l": "oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group."], "t": []}, {"i": "EC:1.9.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683672", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680811", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62942", "l": "acetate + cytosine + H(+) => H2O + N(4)-acetylcytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54831", "l": "dimethylamine + H(+) + NADPH + O2 <=> formaldehyde + H2O + methylamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22809", "l": "6-hydroxynicotinate + H2O + O2 => 2,6-dihydroxynicotinate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40367", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688456", "l": "MLKL binds FLOT1, FLOT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27635", "l": "5-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42687", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O <=> L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791123", "l": "Expression of KDELR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74142", "l": "petunidin + UDP-alpha-D-glucose <=> petunidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51461", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate => (9Z)-octadecenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72150", "l": "AH2 + S-adenosyl-L-methionine + UTP <=> 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75417", "l": "pseudooxynicotine => H2O + N-methylmyosmine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801762", "l": "REG3A oligomerize to form a pore complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48039", "l": "a globoside Gb4Cer (d18:1(4E)) + H2O <=> a globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.92", "l": "\"oxaloglycolate reductase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24774", "l": "chlorophyllide b + H(+) + NADPH => 7(1)-hydroxychlorophyllide a + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641134", "l": "SMURF2 binds AXIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63801", "l": "GDP-alpha-D-mannose => GDP-beta-L-gulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76794", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37973", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39964", "l": "2-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098505", "l": "G-rich strand telomeric DNA binding", "d": ["Binding to G-rich, single-stranded, telomere-associated DNA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803890", "l": "SFN dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15534", "l": "(2R)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18361", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.2.33", "l": "\"dolichyl-xylosyl-phosphate--protein xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72348", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole => 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48100", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.321", "l": "\"type III protein arginine methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182990", "l": "Sprouty sequesters CBL away from active EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31036", "l": "arabidiol => (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655086", "l": "ATF4 binds the DDIT3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033445", "l": "AGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGU codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15142", "l": "4-methylphenol + H2O + 4 oxidized [azurin] => 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30792", "l": "dGTP + pyruvate => dGDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29072", "l": "a ubiquinone + formate + H(+) => a ubiquinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33383", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine = (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45917", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.29", "l": "\"25/26-hydroxycholesterol 7alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15966", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.81", "l": "\"ADAM10 endopeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353277", "l": "Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27880", "l": "3'-UMP + H(+) => 2',3'-cyclophospho-UMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57069", "l": "3-oxoisoapionate + ATP => 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983147", "l": "Release of E3 from polyubiquitinated substrate (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23605", "l": "kievitone hydrate => H2O + kievitone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9005980", "l": "IL21 binds IL21R:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23348", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.44", "l": "\"4-carboxymuconolactone decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12978", "l": "H2O + N-phosphocreatine => creatine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035960", "l": "Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32935", "l": "a cardiolipin + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625124", "l": "GCK gene expression is inhibited by FOXO1, SIN3A and HDACs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73546", "l": "dCDP(out) + UTP(in) <=> dCDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73947", "l": "(2E)-geranyl diphosphate = (4E,6E)-allo-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847537", "l": "RAB43:GTP binds USP8NL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68001", "l": "1,1-dichloroethene + AH2 => A + chloride + chloroethene + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.134", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34173", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => L-aspartate 4-semialdehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426263", "l": "Dystroglycan binds NRXN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30591", "l": "H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66125", "l": "2-oxobutanoate + L-histidine => (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62513", "l": "2-oxoglutarate + melatonin + O2 => 2-hydroxymelatonin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51587", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41126", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61141", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + myricetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47495", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190141", "l": "ALAD binds to Pb2+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654623", "l": "Activated FGFR3 binds FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18156", "l": "2 GTP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34835", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine = a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76042", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31268", "l": "6-hydroxyhexanoate + NADP(+) => 6-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41699", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.159", "l": "\"theobromine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65652", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine = a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814096", "l": "ARL1:GTP binds SCOC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65582", "l": "H(+) + phosphate + TDP => H2O + TTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103069", "l": "17-hydroxyprogesterone 21-hydroxylase activity", "d": ["Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27475", "l": "ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-beta-D-manno-heptose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10990", "l": "2 e(-) + 2 H(+) + 2 nitric oxide => H2O + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605797", "l": "SMPD1 hydrolyzes SPHM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33794", "l": "H2O + sucrose 6(F)-phosphate <=> beta-D-fructose + beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182988", "l": "Sprouty lures CBL away from EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58114", "l": "acetate + ADP-D-ribose + H(+) => 1''-O-acetyl-ADP-alpha-D-ribose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38786", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22977", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65104", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] = aculene B + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22668", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012650", "l": "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60068", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089971", "l": "Secretion of collagens (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52865", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23206", "l": "2-O-caffeoylglucarate + L-quinate => chlorogenate + D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72892", "l": "acetylcholine(out) + 2 H(+)(in) => acetylcholine(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53102", "l": "2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0160011", "l": "NAD-dependent protein decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:69332", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624272", "l": "MMPs cleave HB-EGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60935", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174119", "l": "Free APC/C phosphorylated by Plk1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112042", "l": "Opioid binds MOR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158860", "l": "SULT1A1 dimer sulfonates NHABP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047996", "l": "hydroxyphytanate oxidase activity", "d": ["Catalysis of the reaction: (2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15176", "l": "H(+) + H2O2 + NADPH <=> 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59467", "l": "NADP(+) + octadecan-1-ol <=> H(+) + NADPH + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10378", "l": "ADP + Cu(2+)(out) + H(+) + phosphate => ATP + Cu(2+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74190", "l": "S-adenosyl-L-methionine + taxifolin <=> H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199299", "l": "AKT phosphorylates FOXO transcription factors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11825", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50305", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714580", "l": "SLC6A3 binds DRIs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27828", "l": "L-homocysteine + succinate => hydrogen sulfide + O-succinyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41123", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54990", "l": "2 H2O(in) => 4 e(-) + 4 H(+)(in) + O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51343", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183067", "l": "Localization of CBL:GRB2 to the membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018702", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47960", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035402", "l": "histone H3T11 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252133", "l": "ATP6AP1 binds V-ATPase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68393", "l": "H2O + peracetic acid => acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50067", "l": "ATP + H2O + taurochenodeoxycholate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050649", "l": "testosterone 6-beta-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67340", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside = CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17343", "l": "1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH => 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37533", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53009", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate => di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23213", "l": "H2O + N-acetyl-beta-alanine => acetate + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381727", "l": "RAP1A exchanges GDP for GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15500", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205244", "l": "Recruitment of CBL to KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77389", "l": "an alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68751", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] <=> alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35957", "l": "6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75302", "l": "NAD(+) <=> 2'cADPR + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22607", "l": "D-mannose <=> D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6803890", "l": "SFN dimerizes (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77262", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701147", "l": "TRPV1 binds TRPV1 blockers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36329", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate => ADP + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69623", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983307", "l": "IL15 binds IL15RA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47135", "l": "11-cis-retinal + H2O + NAD(+) <=> 11-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13553", "l": "alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.6", "l": "\"galactokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71667", "l": "malonate(out) + succinate(in) = malonate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58110", "l": "acetate + L-lysyl-[protein] => H2O + N(6)-acetyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70851", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74482", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 <=> (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63363", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11188", "l": "3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.5.4", "l": "\"cyanoalanine nitrilase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20943", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50177", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57996", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30522", "l": "GTP + H(+) + phosphoenolpyruvate <=> diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47176", "l": "(2R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592387", "l": "Fibulin binds elastic fibres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43262", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19375", "l": "2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23839", "l": "D-methionine + pyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42912", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.191", "l": "\"23S rRNA (cytosine(1962)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212642", "l": "L-Glutamine transport into neurons (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730882", "l": "Phosphorylation of PKC-theta (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67740", "l": "N-acetyl-beta-neuraminate = aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32195", "l": "abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76304", "l": "L-cystine(out) => L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48177", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042392", "l": "sphingosine-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67431", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65858", "l": "a steroid 1,3-dione + AH2 => A + a 1-hydroxy-3-oxo steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.3", "l": "\"kynureninase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043854", "l": "cyclic nucleotide-gated mechanosensitive monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0033038", "l": "bitter taste receptor activity", "d": ["Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222093", "l": "BRD7 binds TP53 and EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676264", "l": "Formation of the SET1B complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30171", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61394", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => ATP + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835121", "l": "Heparin binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070448", "l": "laricitrin 5'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22282", "l": "H(+) + puromycin + S-adenosyl-L-homocysteine => O-demethylpuromycin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55623", "l": "a carotenoid psi-end group <=> a carotenoid beta-end derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964496", "l": "STING binds TRIM32 or TRIM56  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68948", "l": "esculetin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794347", "l": "Homer1,2,3 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112379", "l": "Recruitment of elongation factors to form elongation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61692", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP = AMP + L-threonyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.352", "l": "\"5'-hydroxyaverantin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72449", "l": "a dicarboxylate(out) + estrone 3-sulfate(in) => a dicarboxylate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167511", "l": "HLCS biotinylates ACACB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37212", "l": "2',3'-cyclophospho-GMP + H2O => guanosine 2'-monophosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75082", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65594", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48274", "l": "2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042931", "l": "enterobactin transmembrane transporter activity", "d": ["Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009927", "l": "histidine phosphotransfer kinase activity", "d": ["Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015109", "l": "chromate transmembrane transporter activity", "d": ["Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3."], "t": []}, {"i": "RHEA:32819", "l": "chromate(in) = chromate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39814", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13843", "l": "Fe(III)2-[transferrin] + NADH => Fe(II)2-[transferrin] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26079", "l": "formaldehyde + H2O + NAD(+) + sulfite => methanesulfonate + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58710", "l": "rifampicin para-naphthoquinone carboxamide => rifampicin ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38817", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844617", "l": "IPAF binds procaspase-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851933", "l": "MET phosphorylates GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34811", "l": "NADP(+) + tetrahydrocurcumin = dihydrocurcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29274", "l": "a menaquinol + H(+) + trimethylamine N-oxide <=> a menaquinone + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28278", "l": "3-sulfino-L-alanine + H2O = H(+) + L-alanine + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398185", "l": "LARG binds plexin B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990422", "l": "glyoxalase (glycolic acid-forming) activity", "d": ["Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64801", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0030572", "l": "phosphatidyltransferase activity", "d": ["Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156699", "l": "Inactivation of Wee1 kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653850", "l": "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77104", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O => 2-(9Z-octadecenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29295", "l": "aldehydo-D-galacturonate(out) + H(+)(out) = aldehydo-D-galacturonate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658813", "l": "OGG1 S326C is oxidized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55376", "l": "2 a quinol + O2 = 2 a quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65593", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14811", "l": "anisole + H(+) + S-adenosyl-L-homocysteine => phenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34772", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) => a 3-oxosteroid + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27983", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) => 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023132", "l": "AURKB phosphorylates MECP2 at S423 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203973", "l": "Vesicle budding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817289", "l": "DUX4 binds HERVL LTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37202", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877153", "l": "STARD7 binds PC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76439", "l": "19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051425", "l": "PTB domain binding", "d": ["Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804100", "l": "HMGB1 binds LPS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28937", "l": "oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11711", "l": "H2O + IMP + NAD(+) <=> H(+) + NADH + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912401", "l": "NOTCH4 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50717", "l": "dimethyl sulfone + FMNH2 + O2 => FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46257", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69809", "l": "AMP + benzoyl-CoA + H(+) => benzoyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61786", "l": "keto-L-fructose => L-allulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22109", "l": "L-threonine => 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168376", "l": "STIM1 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8979071", "l": "KDM6B binds iron (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38490", "l": "1-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67445", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA => a long-chain fatty aldehyde + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13879", "l": "an L-alpha-amino acid + L-glutamate 5-semialdehyde => a 2-oxocarboxylate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63531", "l": "[thioredoxin]-dithiol + H2O2 <=> [thioredoxin]-disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689630", "l": "BAP1 binds BAP1-interacting complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686930", "l": "RIPK3 is cleaved by CASP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44597", "l": "a fatty acyl-[ACP] + H2O => a fatty acid + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70766", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434836", "l": "Syk/Lck phosphorylate LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198314", "l": "DAG stimulates protein kinase C-delta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40582", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68107", "l": "all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833436", "l": "RSV N binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39348", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466822", "l": "Defective OPN1LW causes BCM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202722", "l": "CD48 binds CD244 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847537", "l": "RAB43:GTP binds USP8NL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.35", "l": "\"sn-2 acyl-lipid omega-3 desaturase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047858", "l": "dihydroxyfumarate decarboxylase activity", "d": ["Catalysis of the reaction: dihydroxyfumarate + H+ = 2-hydroxy-3-oxopropanoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67214", "l": "(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2 => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.22821697197837", "identifiers": [{"i": "GO:0016824", "l": "hydrolase activity, acting on acid halide bonds", "d": ["Catalysis of the hydrolysis of any acid halide bond."], "t": []}, {"i": "EC:3.8.-.-", "l": "\"Acting on halide bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41938", "l": "a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047466", "l": "2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity", "d": ["Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71130", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) <=> H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37146", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51789", "l": "2-hydroxybenzoyl-5'-AMP + CoA => 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51924", "l": "AH2 + menaquinone-9 = A + beta-dihydromenaquinone-9", "d": [], "t": []}, {"i": "EC:1.3.99.38", "l": "\"menaquinone-9beta-reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60842", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15792", "l": "L-xylose + NADP(+) <=> H(+) + L-xylono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26490", "l": "a secondary nitroalkane + H2O + O2 = a ketone + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663002", "l": "MT3 binds copper (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52514", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+) => a quinone + trans-4-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102839", "l": "1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76998", "l": "H(+) + NADP(+) + 2 reduced [4Fe-4S]-[ferredoxin] <=> NADPH + 2 oxidized [4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10408", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050068", "l": "lysine carbamoyltransferase activity", "d": ["Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70230", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA <=> (E)-2-benzylidenesuccinyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611851", "l": "ADRB2 bind ADR,NAd (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21104", "l": "AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.38", "l": "\"cholesterol 25-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19653", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65509", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 => H2O2 + NH4(+) + pre-mycofactocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607751", "l": "TRAF6 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60911", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46558", "l": "7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757688", "l": "SERPINA6 binds PREDN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69359", "l": "H(+) + hypobromite + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48893", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33924", "l": "(1R,4R)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25934", "l": "4-methylquinolin-2(1H)-one + AH2 => 4-methylquinoline + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102144", "l": "carboxyspermidine dehydrogenase II activity", "d": ["Catalysis of the reaction: carboxyspermidine + H2O + NADP = L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168929", "l": "Viral dsRNA:TLR3 recruits TRIF (TICAM1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38418", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912734", "l": "CBL:CRKL binds RAPGEF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37977", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate => H(+) + homogentisate + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111962", "l": "PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25097", "l": "ATP + dCMP <=> ADP + dCDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11649", "l": "(-)-menthol + H(+) + NADPH + O2 => 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12514", "l": "H2O2 + NH4(+) + oxaloacetate => D-aspartate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29984", "l": "cytidine(in) + H(+)(in) => cytidine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749215", "l": "MCM8 binds CDC6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168376", "l": "STIM1 oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62514", "l": "2-hydroxymelatonin + CO2 + succinate => 2-oxoglutarate + melatonin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211951", "l": "CYP1B1 4-hydroxylates EST17b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50540", "l": "prostaglandin A2 = prostaglandin C2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13945", "l": "(S)-mandelate = (R)-mandelate", "d": [], "t": []}, {"i": "EC:5.1.2.2", "l": "\"mandelate racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194678", "l": "CYP51A1 demethylates LNSOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49612", "l": "(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.399", "l": "\"2-oxoglutarate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71885", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide => GMP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61815", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose <=> dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022065", "l": "DSPGs are secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41296", "l": "H2O + N-(hexanoyl)sphing-4-enine => hexanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445149", "l": "14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65114", "l": "aculene C + CO2 + H2O + succinate => 2-oxoglutarate + aculene D + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034788", "l": "2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39282", "l": "ATP + dodecanoate(out) + H2O <=> ADP + dodecanoate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036320", "l": "mating-type P-factor pheromone receptor activity", "d": ["Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16103", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877620", "l": "ECE2 cleaves EDN1(53-90) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32938", "l": "a cardiolipin + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047074", "l": "4-hydroxycatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene-1,2,4-triol + O2 = maleylacetate + 2 H(+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17846", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41713", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47166", "l": "CO2 + NADH + zymosterone => 4alpha-carboxyzymosterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103002", "l": "16-hydroxypalmitate dehydrogenase activity", "d": ["Catalysis of the reaction: 16-hydroxypalmitate + NADP = H+ + 16-oxo-palmitate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38294", "l": "(S)-malyl-CoA + H2O <=> (S)-malate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45491", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24284", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.11", "l": "\"aspartate-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679145", "l": "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706336", "l": "Active FLT3 binds to SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17715", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine => (R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62098", "l": "2-(9Z-octadecenoyl)-glycerol + phosphate => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419461", "l": "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64969", "l": "dUTP + H2O => dUDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72060", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) => glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58001", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg3 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033717", "l": "gluconate 2-dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60372", "l": "D-fructose(out) = D-fructose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26223", "l": "abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57116", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418456", "l": "cGMP is degraded by PDEs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54725", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43118", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029273", "l": "PI3K binds to p-6Y-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113643", "l": "Replication initiation regulation by Rb1/E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.29", "l": "\"phycobiliprotein cysteine-84 phycobilin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50908", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.60", "l": "\"3-demethoxyubiquinol 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66456", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46714", "l": "H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668904", "l": "Formation of the CTF18 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65980", "l": "hnu + previtamin D3 = tachysterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855232", "l": "RELN:VLDLR binds DAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12491", "l": "2-amino-2-deoxy-D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062057", "l": "L-aspartate:fumarate antiporter activity", "d": ["Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12630", "l": "2-oxoglutarate + L-hyoscyamine + O2 => (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75154", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + neoverrucosan-5beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416358", "l": "G alpha (q) inhibits PI3K alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667965", "l": "ANKLE2 binds PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047712", "l": "Cypridina-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70704", "l": "D-cycloserine(in) + H(+)(in) => D-cycloserine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102720", "l": "acetyl-coenzyme A:acetyl alcohol acetyltransferase activity", "d": ["Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67955", "l": "an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28182", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": [], "t": []}, {"i": "EC:5.3.3.17", "l": "\"trans-2,3-dihydro-3-hydroxyanthranilate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46124", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.26", "l": "\"24-hydroxycholesterol 7alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72456", "l": "fumarate(out) + 3 H(+)(out) => fumarate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31276", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201457", "l": "BMP2 binds to the receptor complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61359", "l": "ATP + H2O + methotrexate(in) <=> ADP + H(+) + methotrexate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55438", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55395", "l": "an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810843", "l": "Envoplakin binds periplakin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2248891", "l": "M6PR transports activated ARSA to the lysosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31214", "l": "ATP + H2O + L-selenomethionine <=> diphosphate + L-adenosylselenomethionine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60847", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203516", "l": "Alpha-1-Microglobulin is cleaved (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76783", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,9-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140563", "l": "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "d": ["Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63894", "l": "AMP + D-tryptophan + diphosphate + H(+) => ATP + H2O + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352059", "l": "SLC6A15-mediated amino acid uptake (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70428", "l": "H2O + phenylacetyl-CoA => 2-phenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64330", "l": "cholesteryl (7Z)-octadecenoate + CoA => (7Z)-octadecenoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199839", "l": "AKT can phosphorylate RSK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73769", "l": "diphosphate + preechinulin => cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102960", "l": "momilactone-A synthase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032565", "l": "dGMP binding", "d": ["Binding to dGMP, deoxyguanosine monophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63553", "l": "angiotensin-(1-7) + H2O => angiotensin-(1-5) + L-histidyl-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983150", "l": "Proteasomal cleavage of substrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.265", "l": "\"3-methylbutanal reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69322", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose => glucoerucin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37702", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102562", "l": "hydroxyproline O-arbinofuranose transferase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36568", "l": "GDP-beta-L-colitose + NAD(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44340", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate = AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": [], "t": []}, {"i": "EC:6.3.2.46", "l": "\"fumarate--(S)-2,3-diaminopropanoate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69661", "l": "beta-D-glucose + kaempferol => H2O + kaempferol 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56224", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.-", "l": "\"Aspartic endopeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40399", "l": "1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035447", "l": "mycothiol synthase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol-2-(L-cysteinylamido)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coA + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.99", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990147", "l": "talin binding", "d": ["Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624953", "l": "ARL13B binds INPP5E (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507868", "l": "Aquaporins passively transport water into cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36148", "l": "acetyl-CoA + benzyl alcohol => benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.92", "l": "\"endopeptidase Clp\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164967", "l": "Unknown carnitine exporter transports CAR from the cytosol to the extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827864", "l": "Expression of CBFA2T2 in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70786", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) <=> H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140696", "l": "(S)-2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990631", "l": "ErbB-4 class receptor binding", "d": ["Binding to the protein-tyrosine kinase receptor ErbB-4/HER4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052763", "l": "ulvan lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391942", "l": "IP receptor can bind prostacyclin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781922", "l": "USP13 binds UFD1L:SKP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16144", "l": "2'-deoxymugineate + NAD(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.82", "l": "\"malate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174097", "l": "Association of Emi1 with Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.275720515981703", "identifiers": [{"i": "GO:0004383", "l": "guanylate cyclase activity", "d": ["Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56604", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0048019", "l": "receptor antagonist activity", "d": ["The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19156", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose <=> 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33240", "l": "L-threonine + NAD(+) => aminoacetone + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603784", "l": "PEX19:class I PMP binds PEX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58727", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134953", "l": "DHX36 or DHX9 binds MyD88 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381608", "l": "cAMP activates EPAC2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592362", "l": "Activation of proMMP7 by MMP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69173", "l": "Joining of adjacent Okazaki fragments (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120319", "l": "long-chain fatty acid omega-1 hydroxylase activity", "d": ["Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase."], "t": []}, {"i": "RHEA:60936", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17143", "l": "glyoxylate + L-aspartate => glycine + oxaloacetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39769", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71849", "l": "LDH tetramer reduces PYR to LACT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368140", "l": "Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25953", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde => 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62866", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14606", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12435", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32632", "l": "erythromycin D + H(+) + NADPH + O2 => erythromycin C + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047575", "l": "4-carboxymuconolactone decarboxylase activity", "d": ["Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54235", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline <=> 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54898", "l": "(10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73621", "l": "CTP(in) + GTP(out) => CTP(out) + GTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106137", "l": "IkappaB kinase complex binding", "d": ["Binding to a IkappaB kinase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56734", "l": "echinenone + H2O => 4,4-dihydroxy-all-trans-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247922", "l": "GGCT transforms gGluCys to OPRO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32282", "l": "allantoate + 2 H(+) + 2 H2O <=> (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173111", "l": "Disassembly of viral capsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32445", "l": "all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404193", "l": "IGF1R phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59491", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62643", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide <=> [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67171", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine <=> 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336182", "l": "GPR37 binds prosaptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613023", "l": "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004165", "l": "delta(3)-delta(2)-enoyl-CoA isomerase activity", "d": ["Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28579", "l": "Co(2+)(in) => Co(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68281", "l": "L-seryl-[protein] + pentanoyl-CoA => CoA + O-pentanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20375", "l": "AMP + diphosphate + propanoyl-CoA => ATP + CoA + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41393", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17546", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] => [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193656", "l": "p75NTR interacts with RIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55655", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046522", "l": "S-methyl-5-thioribose kinase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30226", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide <=> 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22114", "l": "3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15491", "l": "9-riburonosyladenine + H(+) + 2 H2O2 => adenosine + H2O + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53581", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.84", "l": "\"Ste24 endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45502", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37265", "l": "ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate => ATP + H2O + L-alanyl-L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873923", "l": "STARD10 binds LPCAT1 and PC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25597", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": [], "t": []}, {"i": "EC:4.2.99.20", "l": "\"2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761858", "l": "NFE2L2-dependent TALDO1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39623", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781953", "l": "YOD1 binds VCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404142", "l": "atROL binds RBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24708", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose => (6R)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71470", "l": "H2O + substance P <=> L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2167942", "l": "Collagen type XIII ectodomain shedding (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70501", "l": "D-galactose(in) + 2 Na(+)(in) => D-galactose(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29285", "l": "L-alanine(out) + Na(+)(out) => L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59450", "l": "dodecanal + H(+) + NADPH => dodecan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27628", "l": "beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602272", "l": "Defective CYP4F22 does not 20-hydroxylate TrXA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64154", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11621", "l": "H2O + L-2-amino-4-chloropent-4-enoate => 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014294", "l": "RAC2 binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197770", "l": "STAB1 (FEEL-1) binds ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389463", "l": "Proteinase-activated receptors can bind thrombin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10280", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.-", "l": "\"Protein-histidine kinases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65326", "l": "chrodrimanin B + CoA => acetyl-CoA + chrodrimanin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39173", "l": "(3R)-hydroxyeicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46362", "l": "1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29060", "l": "2 H(+)(in) + H2 + ubiquinone-8 => 2 H(+)(out) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65448", "l": "butanoyl-CoA + ethanol = CoA + ethyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33912", "l": "an N-alkylglycine + H2O + O2 => an alkylamine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60322", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23676", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}, {"i": "EC:6.3.2.13", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016617", "l": "4-oxoproline reductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19424", "l": "(R)-2-hydroxypropyl-coenzyme M <=> (R)-1,2-epoxypropane + coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69008", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 = 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.248", "l": "\"L-aspartate N-monooxygenase (nitrosuccinate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917700", "l": "MVB Vesicle Formation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43129", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050483", "l": "IMP 5'-nucleotidase activity", "d": ["Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.2", "l": "\"carboxypeptidase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68357", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate => L-glutamate + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36734", "l": "1-nitrocyclohexan + NADP(+) <=> 1-nitrocyclohexene + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71276", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) => 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48855", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 <=> 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977237", "l": "IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25785", "l": "2-dehydro-3-deoxy-L-rhamnonate => (S)-lactaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56146", "l": "a quinone + H2O + nitrite => a quinol + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170005", "l": "cyclic nucleotide phosphodiesterase activator activity", "d": ["Binds to and increases the activity of cyclic nucleotide phosphodiesterase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36289", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55382", "l": "a 3-oxo bile acid CoA + H(+) + NADH => a 3alpha-hydroxy bile acid CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35476", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047042", "l": "androsterone dehydrogenase (B-specific) activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75137", "l": "H(+) + NADPH + neopinone => NADP(+) + neopine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183051", "l": "CBL ubiquitinates Sprouty (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799431", "l": "TP53 binds HIPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77557", "l": "a 1,3-diacyl-sn-glycerol + CoA => a 3-acyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901612", "l": "cardiolipin binding", "d": ["Binding to cardiolipin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804425", "l": "TP53 binds POU4F2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161282", "l": "Elastic fibres bind associated proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029476", "l": "Role of myosins in phagosome formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28699", "l": "Mn(2+)(in) = Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58782", "l": "a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59183", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O <=> 2 AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938887", "l": "PML binds RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050233", "l": "pyranose oxidase activity", "d": ["Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31296", "l": "(2E)-2-hydroxypenta-2,4-dienoate => 2-oxopent-4-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62105", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49471", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose <=> a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38472", "l": "L-histidine + 3 S-adenosyl-L-methionine => 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70745", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112435", "l": "Formation of Elongin BC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69152", "l": "Removal of remaining Flap (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49443", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA <=> (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047829", "l": "D-nopaline dehydrogenase activity", "d": ["Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371582", "l": "HSBP1 binds HSF1 trimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031882", "l": "type 5 somatostatin receptor binding", "d": ["Binding to a type 5 somatostatin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38498", "l": "a triacylglycerol + H2O <=> a 1,3-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102830", "l": "verbascose synthase activity", "d": ["Catalysis of the reaction: 2 stachyose = verbascose + raffinose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11537", "l": "choline + H2O + 2 O2 => glycine betaine + H(+) + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68839", "l": "(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-himachala-9,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73653", "l": "CTP(in) => CTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18685", "l": "H(+) + NADPH + O2 + pentachlorophenol = 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48474", "l": "a ganglioside GD1a + N-acetylneuraminate => a ganglioside GT1a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396399", "l": "Fibrillins bind BMPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070878", "l": "primary miRNA binding", "d": ["Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640862", "l": "Tankyrase binds AXIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26527", "l": "a (3R)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031682", "l": "G-protein gamma-subunit binding", "d": ["Binding to a G-protein gamma subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102280", "l": "choline monooxygenase activity (NADP-dependent)", "d": ["Catalysis of the reaction: choline + NADP = betaine aldehyde + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449829", "l": "IL11 binds IL11RA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31216", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) => (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46920", "l": "(E)-cinnamate + H(+) = CO2 + styrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71328", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) => chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11410", "l": "lumichrome + ribitol => H(+) + H2O + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49669", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432010", "l": "Aquaporin-1 passively transports water into cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165195", "l": "GTP loading by Rheb (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60485", "l": "CTP + UTP => cyclic CMP-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.99", "l": "\"arabinan endo-1,5-alpha-L-arabinosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15522", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50720", "l": "FMNH2 + methanesulfinate + O2 = FMN + H(+) + H2O + methanesulfonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75379", "l": "H2O + L-canavanine = L-homoserine + N-hydroxyguanidine", "d": [], "t": []}, {"i": "EC:4.4.1.43", "l": "\"canavanine-gamma-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40026", "l": "9alpha-copalyl diphosphate + H2O <=> diphosphate + syn-copalol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918230", "l": "Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32194", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61068", "l": "acetyl-CoA + horhammericine = 19-O-acetylhorhammericine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679205", "l": "ULK1 phosphorylates Beclin-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009817", "l": "Acitretin binds to RAR:RXR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371591", "l": "Trimerization of cytosolic HSF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59922", "l": "(2E)-octenoate + 2 H(+) + NADH => (2E)-octenal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61800", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine = AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.67", "l": "\"L-alanine--[L-alanyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031810", "l": "H4 histamine receptor binding", "d": ["Binding to a H4 histamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874083", "l": "p-Y397-PTK2 binds SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13678", "l": "D-ribulose 5-phosphate => D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42606", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202164", "l": "Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659755", "l": "Defective SLC6A18 does not transport Gly from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351894", "l": "Caspase mediated cleavage of BAP31 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20899", "l": "ATP + hydrogencarbonate + urea <=> ADP + H(+) + phosphate + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45106", "l": "mitomycin A + S-adenosyl-L-homocysteine => 6-demethylmitomycin A + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12377", "l": "ATP + L-fuculose => ADP + H(+) + L-fuculose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983688", "l": "OAS1 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57018", "l": "3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40405", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070675", "l": "hypoxanthine oxidase activity", "d": ["Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2."], "t": []}, {"i": "REACT:R-HSA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59554", "l": "H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => N,N',N'',N'''-tetraacetylchitotetraose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83650", "l": "FasL:Fas binds FADD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50299", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53816", "l": "hydrogen sulfide + O-succinyl-L-serine = L-cysteine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008792", "l": "arginine decarboxylase activity", "d": ["Catalysis of the reaction: L-arginine + H+ = agmatine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15375", "l": "H(+) + palmatine + S-adenosyl-L-homocysteine => columbamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69005", "l": "Cdc6 protein is phosphorylated by CDK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18911", "l": "2,4,6-trichloroanisole + S-adenosyl-L-homocysteine => 2,4,6-trichlorophenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606564", "l": "GALC hydrolyzes GalCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.050016418185038", "identifiers": [{"i": "GO:0061733", "l": "peptide-lysine-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050044", "l": "galactose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61146", "l": "H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP => myricetin + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12013", "l": "ATP + thiamine => ADP + H(+) + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34519", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine = [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": [], "t": []}, {"i": "EC:2.4.1.292", "l": "\"GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77737", "l": "2 H(+) + IMP + 2 phosphate => 2 H2O + ITP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59582", "l": "CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954082", "l": "E2F6 binds the PRC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051719", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658435", "l": "RAS GAPs bind RAS:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27844", "l": "2'-aminobiphenyl-2,3-diol + NADP(+) => 9H-carbazole + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47601", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate => a ganglioside GM4 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32034", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-curcumene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106144", "l": "fraxetin 5-hydroxylase activity", "d": ["Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530573", "l": "CREG(CR1L) binds to surface-bound C3 convertases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57240", "l": "glyoxal + GMP = N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24578", "l": "H(+) + 2 phosphate => diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20974", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72350", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole <=> 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64526", "l": "2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] => (2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877192", "l": "RUNX1 binds FOXP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.133", "l": "\"glucan 1,4-alpha-maltohydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43013", "l": "L-homocysteine => 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.276", "l": "\"gibberellin A4 carboxyl methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40657", "l": "(R)-malyl-CoA + succinate => (R)-malate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22160", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.173", "l": "\"flavonol-3-O-triglucoside O-coumaroyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38096", "l": "gamma-tocotrienol + S-adenosyl-L-methionine => alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27793", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13895", "l": "ADP + AMP + 2 H(+) => H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53727", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52856", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": [], "t": []}, {"i": "EC:1.5.8.4", "l": "\"dimethylglycine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028812", "l": "Expression of interferon-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37692", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022465", "l": "MECP2 mutants R106W, D121G, R133H, S134F, T158M and T158A do not bind to 5mC-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19804", "l": "(R)-4'-phosphopantetheine + ATP + H(+) <=> 3'-dephospho-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57627", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800298", "l": "HGF dimer binds MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75929", "l": "cyclohexanone + H(+) + NADH + NH4(+) => cyclohexylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141367", "l": "Myristoylation of tBID by NMT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003876", "l": "AMP deaminase activity", "d": ["Catalysis of the reaction: AMP + H2O = IMP + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247836", "l": "Retromer recycles WLS to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70462", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45379", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013023", "l": "RHOB GEFs activate RHOB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30951", "l": "(2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.85", "l": "\"alpha-eudesmol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65189", "l": "2-oxoglutarate + berkeleyone B + O2 => berkeleydione + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61119", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18805", "l": "[DsbA protein]-disulfide + [protein]-dithiol = [DsbA protein]-dithiol + [protein]-disulfide", "d": [], "t": []}, {"i": "EC:1.8.4.15", "l": "\"protein dithiol oxidoreductase (disulfide-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54731", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33147", "l": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.2", "l": "\"ABC-type xenobiotic transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59160", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659611", "l": "ANO1 inhibitors bind ANO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64291", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] <=> cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749590", "l": "ASA- acetylates ALB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047183", "l": "anthocyanin 5-aromatic acyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65456", "l": "2-methylbutan-1-ol + acetyl-CoA = 2-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61212", "l": "myricetin + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48525", "l": "a ganglioside GP1c + H2O => a ganglioside GQ1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61412", "l": "ATP + N-(D-erythrulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35040", "l": "spermidine(in) => spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827995", "l": "Expression of NANOS3 in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10614", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390909", "l": "HRH2 binds hist (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391936", "l": "EP1 receptor can bind PGE2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73603", "l": "CMP(in) + CTP(out) = CMP(out) + CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28627", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27803", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => all-trans-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45470", "l": "(Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197770", "l": "STAB1 (FEEL-1) binds ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50481", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61797", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP => AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420233", "l": "VIP receptors bind VIP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72154", "l": "estrone 3-sulfate(out) + glutarate(in) <=> estrone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627089", "l": "CASP9 is phosphorylated at T412 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0032138", "l": "single base insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing a single base insertion or deletion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625346", "l": "SREBF1 gene expression is inhibited by FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176116", "l": "Recruitment and activation of Chk1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31198", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53986", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729318", "l": "CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52967", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35293", "l": "3-oxoisopentadecanoyl-CoA + CO2 + CoA => 11-methyldodecanoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10203", "l": "butanoate + NAD(+) <=> (2E)-2-butenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54435", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13287", "l": "ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate => ATP + L-cysteine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836435", "l": "p-PKR dimer phosphorylates SNCA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18761", "l": "a 1,2-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37103", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19602", "l": "H(+) + NADH + O2 + orcinol => 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0089721", "l": "phosphoenolpyruvate transmembrane transporter activity", "d": ["Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25486", "l": "(1S,4R)-camphene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11681", "l": "ATP + H2O + L-glutamine + XMP => AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46144", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52848", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66787", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) <=> 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33106", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-muurolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64260", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine = CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53898", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5221061", "l": "TDG excises 5-carboxylcytosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40022", "l": "ent-copalyl diphosphate + H2O <=> (-)-ent-copalol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70692", "l": "ornithine => putrescine + CO2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610270", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3A (GRIN3A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612219", "l": "ERBB4s80 binds to SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211224", "l": "Association of DFF40 with DFF45 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392513", "l": "Rap1 signal termination by Rap1GAPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11677", "l": "D-ribose + H2O + NADP(+) => D-ribonate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678843", "l": "ISGylation of protein translation regulator 4EHP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1901236", "l": "4-(trimethylammonio)butanoate transmembrane transporter activity", "d": ["Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other."], "t": []}, {"i": "RHEA:32835", "l": "4-(trimethylamino)butanoate(in) = 4-(trimethylamino)butanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001018", "l": "mitochondrial promoter sequence-specific DNA binding", "d": ["Binding to a DNA region that controls the transcription of the mitochondrial DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419166", "l": "GEFs activate RhoA,B,C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66230", "l": "asc-DeltaC13-CoA + H2O2 => asc-C13-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830765", "l": "Expression of GDNF in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29335", "l": "H2O + L-alanyl-L-glutamate = L-alanine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036056", "l": "Defective HGSNAT does not acetylate Heparan sulfate chain(3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030759", "l": "methylquercetagetin 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17480", "l": "precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40570", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 <=> A + dTDP-beta-L-evernitrose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12777", "l": "2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + chemical entity", "d": [], "t": []}, {"i": "EC:1.17.3.1", "l": "\"pteridine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65155", "l": "(2S)-naringenin + UDP-alpha-D-glucose <=> (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034924", "l": "cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28477", "l": "D-glucarate(in) + H(+)(in) <=> D-glucarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033960", "l": "N-methyl nucleosidase activity", "d": ["Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + H+ + ribofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58226", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide => L-glutamyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.434", "l": "\"2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088152", "l": "FOXM1 stimulates CDC25A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33630", "l": "ATP + CoA + decanoate <=> AMP + decanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73838", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71410", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13738", "l": "an n-alkanal + NADP(+) => an alk-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005536", "l": "glucose binding", "d": ["Binding to D- or L-enantiomers of glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735151", "l": "Expression of ISL1 in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73157", "l": "adenosine 3',5'-bisphosphate(in) + FMN(out) => adenosine 3',5'-bisphosphate(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75063", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102834", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11672", "l": "chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.85", "l": "\"aminodeoxychorismate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33410", "l": "ATP + glycine + H(+) <=> diphosphate + glycyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769812", "l": "Spike Trimer Translocates to the Plasma Membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52961", "l": "hyocholate + UDP-alpha-D-glucuronate => hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8858500", "l": "CLEC10A binds Tn-MUC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74313", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42822", "l": "H2O + 2 NADP(+) + tetracenomycin C => 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38937", "l": "cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41308", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13795", "l": "2-methylene-3-methylsuccinate => 2-methyleneglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13470", "l": "A + H2O + thymine => 5-methylbarbiturate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606789", "l": "ARSB hydrolyses DS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53848", "l": "NAD(+) + taurocholate = 7-oxo-taurodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56408", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18880", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14558", "l": "H2O + raucaffricine => D-glucose + vomilenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39385", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46047", "l": "(3Z)-octenoyl-CoA <=> (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53761", "l": "allocholate + deoxycholoyl-CoA => allocholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655348", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110208", "l": "NTHL1 glycosylase mediated recognition and binding of cytosine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2197690", "l": "Detachment of WASP/WAVE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047483", "l": "imidazoleacetate-phosphoribosyldiphosphate ligase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167150", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013009", "l": "RHOA binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72191", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23174", "l": "ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66137", "l": "acetyl-CoA + tyramine => CoA + H(+) + N-acetyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982807", "l": "JAK2 phosphorylation of GHR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59245", "l": "3''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25634", "l": "laricitrin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68983", "l": "NADP(+) + tauroursodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48837", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70901", "l": "(2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936628", "l": "GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183067", "l": "Localization of CBL:GRB2 to the membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725009", "l": "NPM1-ALK translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62720", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I = betaenone B + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015518", "l": "arabinose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28383", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine => D-glucose 6-phosphate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102801", "l": "anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43183", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37859", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782820", "l": "USP17 deubiquitinates SUDS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247837", "l": "WNT ligands traffic to the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39464", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52596", "l": "lithocholoyl-CoA + NAD(+) = 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0099602", "l": "neurotransmitter receptor regulator activity", "d": ["A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14945", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.46", "l": "\"monogalactosyldiacylglycerol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34189", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875077", "l": "SLC27A3 ligates CoA-SH to VLCFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39264", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH => (13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086087", "l": "voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089971", "l": "Secretion of collagens (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202722", "l": "CD48 binds CD244 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36837", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77094", "l": "Formation of cap binding complex (CBC) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362386", "l": "Glycosylation of Hh (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48070", "l": "a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate => a ganglioside GM2 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15714", "l": "a beta-D-galactoside + acetyl-CoA => a 6-acetyl-beta-D-galactoside + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58384", "l": "NADP(+) + octan-1-ol = H(+) + NADPH + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45286", "l": "CoA + H(+) + N-eicosanoyl-sphing-4-enine => eicosanoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47620", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034935", "l": "tetrachlorobenzene dioxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374662", "l": "Translocation of Ezrin to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40861", "l": "(2E,9Z)-hexadecadienoyl-CoA + FADH2 => (9Z)-hexadecenoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55182", "l": "2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylnonanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17454", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine => ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443783", "l": "Interaction of NUMB with L1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69026", "l": "H2O + N,N-dihydroxy-L-aspartate + NADP(+) => H(+) + N-hydroxy-L-aspartate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189406", "l": "4 PBGs bind to form HMB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13352", "l": "jasmonate + S-adenosyl-L-methionine <=> methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17841", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.229", "l": "\"[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10320", "l": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.77", "l": "\"trans-L-3-hydroxyproline dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77609", "l": "3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol) => 2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25712", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14067", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46709", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] => AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682826", "l": "LGI1 binds ADAM11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44093", "l": "ATP + CoA + nonadecanoate => AMP + diphosphate + nonadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804527", "l": "INTL1 binds bacterial glycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46912", "l": "H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38970", "l": "an N-acylsphing-4-enine(in) + ATP + H2O <=> ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12286", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + succinate => 3-hydroxy-3-methylglutarate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956684", "l": "ITCH polyubiquitinates TP73 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65439", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49475", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose <=> H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654511", "l": "FGFRL1 dimer binds FGFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39601", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047632", "l": "agmatine deiminase activity", "d": ["Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30475", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate = D-glucuronate + H(+) + oroxylin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36074", "l": "6-tuliposide A <=> D-glucose + tulipalin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58485", "l": "H2O + N-(acetyl)-sphing-4-enine => acetate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39750", "l": "cholesterol(in) <=> cholesterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67450", "l": "formyl-CoA + heptadecanal => (2R)-2-hydroxyoctadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685345", "l": "Formation of isoAsp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27779", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) => 2-all-trans-octaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110322", "l": "Formation of Pol zeta complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48366", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55872", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.7.1.17", "l": "\"FMN-dependent NADH-azoreductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19843", "l": "CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008787", "l": "allose kinase activity", "d": ["Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10102", "l": "a fatty acid + a sterol + H(+) => a sterol ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47789", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265456", "l": "NPC1L1 binds ezetimibe (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69451", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> delta-cadinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35481", "l": "(S)-5'-oxoaverantin + 2 H(+) + NADH => (1'S,5'R)-5'-hydroxyaverantin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481009", "l": "Exocytosis of platelet dense granule content (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55562", "l": "a hydroxy-epoxy-eicosatetraenoate => a hydroperoxyeicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.672771840408203", "identifiers": [{"i": "GO:0008171", "l": "O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43818", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0008428", "l": "ribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ribonuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20329", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] = ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": [], "t": []}, {"i": "EC:2.7.11.29", "l": "\"[low-density-lipoprotein receptor] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60652", "l": "an N-(acyl)-sphingosylphosphocholine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32163", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine = AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}, {"i": "EC:6.3.2.38", "l": "\"N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41110", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68831", "l": "borneol + NAD(+) <=> camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678998", "l": "Endosomal TLRs pass through the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5099899", "l": "WNT5A binds FZD4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69931", "l": "inosine(out) + Na(+)(out) = inosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66138", "l": "CoA + H(+) + N-acetyltyramine => acetyl-CoA + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32875", "l": "a 1-acyl-sn-glycerol + H2O = a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74439", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696547", "l": "STAMBPL1 is a deubiquitinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52338", "l": "a long-chain fatty acyl-AMP + diphosphate => a long-chain fatty acid + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182990", "l": "Sprouty sequesters CBL away from active EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47862", "l": "a ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate => a ganglioside GT1b (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.24", "l": "\"malyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61469", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22648", "l": "holo-[cytochrome c] = apo-[cytochrome c] + heme b", "d": [], "t": []}, {"i": "EC:4.4.1.17", "l": "\"holocytochrome-c synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40576", "l": "glutaryl-CoA + H2O => CoA + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451470", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.3", "l": "\"ferredoxin--NAD(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875661", "l": "GGA3 associates with activated MET receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008399", "l": "naphthalene hydroxylase activity", "d": ["Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654422", "l": "Activated FGFR4 binds FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52617", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35214", "l": "dIDP + H2O <=> dIMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.11", "l": "\"serine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66048", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44319", "l": "1-dodecanoylglycerol + H2O <=> dodecanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351208", "l": "Spermidine  => N-acetylated spermidine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24422", "l": "formate + N-terminal L-methionyl-[peptide] => H2O + N-terminal N-formyl-L-methionyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57459", "l": "(E)-sinapate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.76", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14033", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.43", "l": "\"glycerophosphoinositol inositolphosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000225", "l": "N-acetylglucosaminylphosphatidylinositol deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665871", "l": "ADRM1 binds 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10471", "l": "D-xylulose 5-phosphate + phosphate <=> acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156682", "l": "PLK1 phosphorylates NUDC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62036", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45919", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654625", "l": "Activated FGFR3 binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59173", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] => AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23718", "l": "(2E)-dodecenoyl-CoA => (3Z)-dodecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139941", "l": "Binding of IP3 to IP3 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141090", "l": "protein serine pyrophosphorylase activity", "d": ["Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate."], "t": []}, {"i": "RHEA:64104", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] = 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296233", "l": "T2Rs bind bitter-tasting compounds (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23446", "l": "H(+) + NADH + pyruvate => (S)-lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42536", "l": "uridine(65) in tRNA = pseudouridine(65) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.26", "l": "\"tRNA pseudouridine(65) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050036", "l": "L-threonate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45294", "l": "2-glyceryl-prostaglandin H2 + A + H2O => 2-glyceryl-prostaglandin G2 + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015381", "l": "high-affinity sulfate transmembrane transporter activity", "d": ["Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52583", "l": "ATP + H2O + Pb(2+)(in) <=> ADP + H(+) + Pb(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013159", "l": "CDC42 GEFs activate CDC42 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004066", "l": "asparagine synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10448", "l": "2-oxoglutarate + a flavanone + O2 = a flavone + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177934", "l": "EGFR autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24052", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.5.5.1", "l": "\"electron-transferring-flavoprotein dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14821", "l": "beta-L-arabinopyranose = L-ribulose", "d": [], "t": []}, {"i": "EC:5.3.1.4", "l": "\"L-arabinose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12833", "l": "an N-acyl-D-glutamate + H2O = a carboxylate + D-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.82", "l": "\"N-acyl-D-glutamate deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33256", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine => H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19504", "l": "4-guanidinobutanoate + H2O <=> 4-aminobutanoate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29140", "l": "2 H(+)(in) + menaquinol-8 + nitrate => 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113454", "l": "RNA Polymerase III Termination and release of transcribed RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000120", "l": "CBLIF binds RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47016", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O = [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49720", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NAD(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36118", "l": "gibberellin A3 + S-adenosyl-L-methionine <=> O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24737", "l": "2-oxoglutarate + 4-hydroxybutanoate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0015049", "l": "methane monooxygenase activity", "d": ["Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77674", "l": "a globoside GalGb4Cer (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a globoside MSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63943", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043910", "l": "ATP:coenzyme F420 adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.378", "l": "\"L-rhamnose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803234", "l": "Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183072", "l": "EGFR non-clathrin mediated endocytosis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54965", "l": "hexadecanoyl-[ACP] + phosphate => hexadecanoyl phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.3", "l": "\"hydrogen dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004715", "l": "non-membrane spanning protein tyrosine kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43596", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40437", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10799", "l": "albendazole + H(+) + NADPH + O2 <=> albendazole S-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50832", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0034069", "l": "aminoglycoside N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047542", "l": "2-furoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH(2) + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59280", "l": "L-asparagine = D-asparagine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52379", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120299", "l": "peptide histaminyltransferase activity", "d": ["Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]."], "t": []}, {"i": "RHEA:66564", "l": "histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45211", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] <=> Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17978", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) => a long-chain fatty acid + 3 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22095", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] <=> 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54619", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 <=> 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655285", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693536", "l": "ATM phosphorylates MDC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22592", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": [], "t": []}, {"i": "EC:5.3.99.6", "l": "\"allene-oxide cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51922", "l": "A + a quinol => a quinone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014320", "l": "SARM binds viral dsRNA:TLR3:TICAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45361", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine => (11Z)-eicosenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49764", "l": "ethylenediaminetriacetate + FMNH2 + O2 = ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030881", "l": "beta-2-microglobulin binding", "d": ["Binding to beta-2-microglobulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76762", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,5-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627350", "l": "SMAC (DIABLO) binds XIAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55898", "l": "5-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17807", "l": "adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015347", "l": "sodium-independent organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015111", "l": "Factor Xa inhibitors binds Xa (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22043", "l": "H2O + N-formyl-L-aspartate <=> formate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070039", "l": "rRNA (guanosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74368", "l": "substance P(out) => substance P(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517705", "l": "p-S318,221-HuR binds mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17534", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33656", "l": "(9Z)-octadecenoate(out) => (9Z)-octadecenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9669893", "l": "KIT binds type I TKIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55900", "l": "chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55425", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] => (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27533", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3S,6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24670", "l": "H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050642", "l": "2-alpha-hydroxytaxane 2-O-benzoyltransferase activity", "d": ["Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43667", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA <=> 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11218", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ADP => a 2'-deoxyribonucleoside 5'-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60395", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O <=> Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50300", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32900", "l": "1,8-cineole + O2 + reduced [flavodoxin] => 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088134", "l": "PLK1 phosphorylates FOXM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008475", "l": "Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033474", "l": "FGFR2b mutants bind an expanded range of ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29216", "l": "fumarate + menaquinol-8 => menaquinone-8 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46631", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH <=> androst-5-en-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12644", "l": "(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48014", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite => 4-methyl-5-nitrocatechol + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051019", "l": "mitogen-activated protein kinase binding", "d": ["Binding to a mitogen-activated protein kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42835", "l": "(2E)-octenal + H(+) + pyruvate <=> (S)-3-acetyloctanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209252", "l": "CI75 inhibits transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25911", "l": "an alditol + O2 <=> an aldose + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11057", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 => 4-aminophenol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140843", "l": "RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 7)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42309", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667456", "l": "AVPR1A,B bind desmopressin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75810", "l": "Na(+)(out) + propanoate(out) <=> Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16893", "l": "pyridine + S-adenosyl-L-methionine = N-methylpyridinium + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.87", "l": "\"pyridine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22088", "l": "ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": [], "t": []}, {"i": "EC:2.7.6.5", "l": "\"GTP diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008412", "l": "CDK4 phosphorylates RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60922", "l": "a cytidine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839100", "l": "p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25525", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66909", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine => 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22009", "l": "L-homoserine + succinyl-CoA => CoA + O-succinyl-L-homoserine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62196", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol = acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47549", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate => 3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20972", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}, {"i": "EC:2.3.1.148", "l": "\"glycerophospholipid acyltransferase (CoA-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48294", "l": "a ganglioside Fuc-GM1 + GDP + H(+) => a ganglioside GM1 + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433456", "l": "Recruitment of STATs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22039", "l": "[phosphate](n) + D-glucose <=> [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693536", "l": "ATM phosphorylates MDC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61674", "l": "diphosphate + L-cysteinyl-5'-AMP => ATP + H(+) + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67205", "l": "H2O + N-acetyltryptamine => acetate + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48511", "l": "cholate + NADP(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15353", "l": "all-trans-violaxanthin + L-ascorbate = all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44472", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392513", "l": "Rap1 signal termination by Rap1GAPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66044", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14404", "l": "chlordecone alcohol + NADP(+) <=> chlordecone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44567", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate <=> 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.2", "l": "\"HslU--HslV peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817575", "l": "ERO1B oxidizes P4HB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62601", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858428", "l": "FCAMR binds IgA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67968", "l": "H2O + presqualene diphosphate = H(+) + phosphate + presqualene monophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102743", "l": "eriodictyol,NADPH:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 = 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411367", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004910", "l": "interleukin-1, type II, blocking receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10811", "l": "(S)-2-hydroxypropylphosphonate + H2O2 <=> (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806419", "l": "TP53 binds the FANCC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31389", "l": "alpha-amyrin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21028", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626228", "l": "The distal appendage proteins recruit TTBK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33745", "l": "an N-acylsphing-4-enine + phosphate => an N-acylsphing-4-enine 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166214", "l": "FA anion flip-flops to the opposite surface (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863727", "l": "STON2 is neddylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427337", "l": "MBD2 binds methylcytosine in chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37069", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11156", "l": "H2O + L-valine + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.8", "l": "\"valine dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69559", "l": "D-glucose(out) + H(+)(out) <=> D-glucose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052629", "l": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57382", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69046", "l": "fumarate + H(+) + nitrite => 2-nitrobutanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74149", "l": "benzoyl-CoA + succinyl-CoA => (S)-2-benzoylsuccinyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11759", "l": "ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.57", "l": "\"fructuronate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17646", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45543", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74000", "l": "dimethylallyl diphosphate + quinolinone B => diphosphate + peniprequinolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22884", "l": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine", "d": [], "t": []}, {"i": "EC:2.6.1.73", "l": "\"methionine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34948", "l": "(Z)-3-aminoacrylate + H(+) + H2O => 3-oxopropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55243", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399930", "l": "Activation of PAK by Rac1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169050", "l": "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12171", "l": "allyl alcohol + NADP(+) <=> acrolein + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33234", "l": "H2O2 + heme b <=> heme d cis-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851436", "l": "CFHR dimers bind C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013159", "l": "CDC42 GEFs activate CDC42 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019826", "l": "oxygen sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24599", "l": "acetyl-CoA + L-histidine <=> CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13095", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69860", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine => a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31743", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine = a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.231", "l": "\"flavonoid 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012208", "l": "miR-26A and B bind to the 3'UTR of the KPNA2 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19947", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76129", "l": "3',5'-cyclic AMP(in) + a dicarboxylate(out) => 3',5'-cyclic AMP(out) + a dicarboxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35158", "l": "(S)-4,5-dihydroxypentane-2,3-dione <=> (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818574", "l": "TASP1 cleaves KMT2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433395", "l": "Dimerization of sSCF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56477", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45962", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52527", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976551", "l": "NOTCH2 stimulates GZMB transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34217", "l": "4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH => 4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51127", "l": "uridine in snRNA <=> pseudouridine in snRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75408", "l": "2-dehydro-D-glucose => cortalcerone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043115", "l": "precorrin-2 dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102320", "l": "1,8-cineole 2-exo-monooxygenase activity", "d": ["Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 = 2-exo-hydroxy-1,8-cineole + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047529", "l": "2,3-dimethylmalate lyase activity", "d": ["Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48447", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158357", "l": "factor XIIa binds SERPING1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43507", "l": "5-hydroxymethylfurfural + O2 <=> 2,5-diformylfuran + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50356", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.233", "l": "\"4-hydroxy-6-methylpretetramide 12a-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47790", "l": "a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 28S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55837", "l": "calcitriol + UDP-alpha-D-glucuronate => calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682377", "l": "LC3 de-lipidation by ATG4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38976", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018732", "l": "sulfolactone hydrolase activity", "d": ["Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951500", "l": "Dissociation of CANX from nonameric complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74833", "l": "UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out) => UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58600", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67031", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O <=> (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24183", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68452", "l": "all-trans-10'-apo-beta-carotenal + O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004635", "l": "phosphoribosyl-AMP cyclohydrolase activity", "d": ["Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74633", "l": "(6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+) => 3-methyl-2-oxobutanoate + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28704", "l": "Cu(2+)(in) => Cu(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004658", "l": "propionyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60693", "l": "(E)-non-2-enal + H2O + NADP(+) => (E)-non-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11912", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018844", "l": "2-hydroxytetrahydrofuran isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693012", "l": "TNFSF15 binds TNFRSF25 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21067", "l": "[protein]-disulfide + 2 glutathione <=> [protein]-dithiol + glutathione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46505", "l": "dodecanoyl-AMP + holo-[ACP] => AMP + dodecanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15119", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine => 3'-dephospho-CoA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798749", "l": "Exocytosis of specific granule lumen proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214956", "l": "Full-length EA is cleaved by SNK serine protease (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25864", "l": "H2O + N(1)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29110", "l": "H(+) + NADH + ubiquinone-8 <=> NAD(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42928", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.199", "l": "\"16S rRNA (cytosine(1402)-N(4))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450551", "l": "AUF1 binds translation and heat shock proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381727", "l": "RAP1A exchanges GDP for GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785898", "l": "IL4R binds JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61261", "l": "H2O + L-glutamine + O2 => 2-oxoglutaramate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.128", "l": "\"7-methylxanthine demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102196", "l": "cortisol dehydrogenase activity", "d": ["Catalysis of the reaction: cortisol + NADP = cortisone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46601", "l": "[HPr protein]-L-serine + ATP => [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39790", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33437", "l": "episterol => fecosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106332", "l": "ds/ssDNA junction-specific dsDNA endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54848", "l": "H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71152", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26180", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.103", "l": "\"N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68932", "l": "ATP + H(+) + NADPH + octanoate = AMP + diphosphate + NADP(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111883", "l": "Hydrolysis of phosphatidylcholine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62762", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25792", "l": "ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.8", "l": "\"P-type Cu(+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21473", "l": "ATP + citrate + CoA => (3S)-citryl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47405", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45652", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13416", "l": "ADP + thymidine <=> AMP + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28122", "l": "ATP + di-trans,octa-cis-undecaprenol = ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33272", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800380", "l": "PTPRD binds IL1RAP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25591", "l": "D-threo-isocitrate + NADP(+) <=> (S)-oxalosuccinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31316", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42534", "l": "pseudouridine(55) in tRNA => uridine(55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66090", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate => L-kynurenine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59058", "l": "dimethyl disulfide + H(+) + NADH => 2 methanethiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62456", "l": "ATP + H(+) + L-glutamate = diphosphate + L-glutamyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62193", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612996", "l": "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57378", "l": "(S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69372", "l": "2-hydroxyhexanoate + O2 = 2-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16357", "l": "A + succinate = AH2 + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191299", "l": "Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437118", "l": "GPVI stimulates PI3K beta, gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38039", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33279", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.156", "l": "\"tryptophan N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20396", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine <=> (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26557", "l": "angiotensin II + H2O <=> angiotensin-(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61143", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + myricetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68442", "l": "(3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal => beta-cryptoxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166792", "l": "Conversion of C2 into C2a and C2b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803063", "l": "RNASEs bind bacterial LPS, PGN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70799", "l": "L-lysine(in) + L-ornithine(out) = L-lysine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30713", "l": "beta-myrcene + H2O => (S)-linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688797", "l": "ATXN3 family cleave Ub chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53545", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33669", "l": "H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33026", "l": "6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13496", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76321", "l": "L-aspartate(out) + L-leucine(in) => L-aspartate(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11007", "l": "2 H(+) + NADH + O2 + salicylate <=> catechol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800315", "l": "MST1 binds MST1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33073", "l": "2-deoxy-L-scyllo-inosose + phosphate => D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17808", "l": "H2O + S-adenosyl-L-homocysteine <=> adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20658", "l": "4-chlorophenylacetonitrile + 2 H2O => 4-chlorophenylacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648888", "l": "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74093", "l": "ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70877", "l": "L-glutamine(out) + L-methionine(in) + Na(+)(in) => L-glutamine(in) + L-methionine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38000", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine => H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38236", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol => 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977271", "l": "Expression of EBF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39450", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.566751859216453", "identifiers": [{"i": "GO:0005048", "l": "signal sequence binding", "d": ["Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64327", "l": "(11Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (11Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426566", "l": "Interaction of DAP12 and CLM7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031814", "l": "P2Y4 nucleotide receptor binding", "d": ["Binding to a P2Y4 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604308", "l": "NICD4 traffics to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23061", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP => a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805981", "l": "HMGB1 release from cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934446", "l": "Activated PKC phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76729", "l": "7-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0033041", "l": "sweet taste receptor activity", "d": ["Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103058", "l": "kaempferol 3-glucoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose = kaempferol-3-glucoside-7-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73320", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA => cimicifugate K + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23694", "l": "H2O + maleate => (R)-malate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22436", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.22", "l": "\"germacradienol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76975", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58711", "l": "rifampicin ortho-naphthoquinone carboxamide <=> rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37627", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30459", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22660", "l": "a fatty acid + ATP + holo-[ACP] = a fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17444", "l": "2-oxoglutarate + L-cysteine <=> 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038186", "l": "lithocholic acid receptor activity", "d": ["Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2002440", "l": "Removal of fibrillar collagen C-propeptides (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690461", "l": "FKBP1A binds tacrolimus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685268", "l": "SARS-CoV-1 8b binds NLRP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15586", "l": "15-cis-phytoene + 4 A => 4 AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45855", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine <=> Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59763", "l": "apigenin + UDP-alpha-D-glucose <=> apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76116", "l": "2-oxoglutarate + O2 + thebaine => 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848436", "l": "PTK6 phosphorylates CDKN1B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008668", "l": "(2,3-dihydroxybenzoyl)adenylate synthase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160103", "l": "tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity", "d": ["Catalysis of the reaction: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74573", "l": "N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71741", "l": "2-oxoadipate(out) + 2-oxoglutarate(in) => 2-oxoadipate(in) + 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24421", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] => formate + N-terminal L-methionyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015196", "l": "L-tryptophan transmembrane transporter activity", "d": ["Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid."], "t": []}, {"i": "REACT:R-HSA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934446", "l": "Activated PKC phosphorylates SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45347", "l": "a globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside NORint (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46387", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177942", "l": "EGFR binds EGF ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65909", "l": "3-hydroxy-L-kynurenine + pyruvate => H2O + L-alanine + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697085", "l": "RNAP transcribes Mtb RNA polyanion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782890", "l": "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785684", "l": "Fibronectin degradation by CTSG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32291", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine = 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50181", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433955", "l": "Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30770", "l": "D-glucurono-3,6-lactone + H2O <=> D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.366", "l": "\"ginsenoside F1 6-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667619", "l": "AVPR1A,B,2 bind atosiban (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46061", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73775", "l": "dimethylallyl diphosphate + preechinulin = diphosphate + tardioxopiperazine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042409", "l": "caffeoyl-CoA O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55498", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70981", "l": "4-aminobutanoate(in) + n H(+)(out) => 4-aminobutanoate(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61446", "l": "an 11a-hydroxytetracycline + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24996", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65847", "l": "ADP(out) + H(+)(out) + phosphate(in) <=> ADP(in) + H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19176", "l": "H(+) + NADH + naphthalene + O2 <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34175", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA = 4-hydroxycoumarin + CO2 + 2 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.208", "l": "\"4-hydroxycoumarin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052740", "l": "1-acyl-2-lysophosphatidylserine acylhydrolase activity", "d": ["Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57289", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O => a guanosine in RNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51130", "l": "AH2 + an aldehyde + NH4(+) => A + an aliphatic amine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71381", "l": "D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in) => D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160935", "l": "SMURF1 ubiquitinates RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37370", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine <=> 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20203", "l": "AMP + D-phenylalanine + diphosphate + H(+) => ATP + H2O + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46055", "l": "a 3'-end uridylyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749920", "l": "HEY1,HEY2 bind GATA4,GATA6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20877", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863718", "l": "AGFG1 binds VAMP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36068", "l": "Co-precorrin-6B + S-adenosyl-L-methionine => Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58359", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65118", "l": "aculene A + CO2 + H2O + succinate => 2-oxoglutarate + aculene B + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37825", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761818", "l": "NFE2L2 binds the GSR gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52388", "l": "ATP + D-threonate = 4-O-phospho-D-threonate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.219", "l": "\"D-threonate 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902122", "l": "chenodeoxycholic acid binding", "d": ["Binding to chenodeoxycholic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791235", "l": "GADD45A binds AURKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30597", "l": "3,4-dihydroxyphenylacetate + FAD + H(+) + H2O => 4-hydroxyphenylacetate + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30268", "l": "2 monodehydro-L-ascorbate radical => L-ascorbate + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730858", "l": "Autophosphorylation of BTK/ITK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0051011", "l": "microtubule minus-end binding", "d": ["Binding to the minus end of a microtubule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24425", "l": "2 glutathione + L-dehydroascorbate => glutathione disulfide + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73006", "l": "anthranilate + 2 ATP + L-tryptophan <=> (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41957", "l": "2',3'-cyclophospho-CMP + H2O => cytidine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432607", "l": "VRI replaces PDP1 as binder to Clk and cry genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940561", "l": "MMP7 cleaves OPTC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23170", "l": "8-oxocoformycin + H(+) + NADPH => coformycin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69127", "l": "Formation of the Flap Intermediate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73374", "l": "(R)-pantothenate(out) + 2 Na(+)(out) <=> (R)-pantothenate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26388", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40373", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696947", "l": "USP47 deubiquitinates POLB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15837", "l": "L-glutamate + methylamine = N-methyl-L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:2.1.1.21", "l": "\"methylamine--glutamate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57224", "l": "glyoxal + GTP = N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21743", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46419", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69597", "l": "AMP + inosine => adenosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869580", "l": "DEK binds TFAP2A homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65177", "l": "A + protoaustinoid A => AH2 + protoaustinoid B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.56", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48885", "l": "NADP(+) + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48506", "l": "D-glycero-D-manno-heptose 1-phosphate + phosphate => D-glycero-D-manno-heptose 1,7-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44971", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21985", "l": "3'-phosphoadenylyl sulfate + choline => adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093331", "l": "Ras:GTP binds p120-RasGAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76939", "l": "2-methylpropan-1-amine + H2O + NADP(+) = 2-methylpropanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51703", "l": "S-adenosyl-L-methionine + xanthogalenol <=> 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61625", "l": "2-oxoglutarate + cadaverine => 5-aminopentanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0086075", "l": "gap junction channel activity involved in cardiac conduction electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75939", "l": "4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52954", "l": "lithocholoyl-24-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48190", "l": "(2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49183", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine <=> a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66990", "l": "4-methylpentanoyl-CoA + AMP + diphosphate => 4-methylpentanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50779", "l": "hexanal + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67216", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27439", "l": "glutathione amide disulfide + 2 H2O => 2 glutathione amide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60294", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64215", "l": "an N-(fatty acyl)-L-isoleucine + H2O <=> a fatty acid + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49848", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36669", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine => (15Z)-tetracosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72621", "l": "Ribosomal scanning  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22968", "l": "butanal + CoA + NAD(+) = butanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60796", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 = 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663120", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19658", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63510", "l": "a (2R)-2-hydroperoxy fatty acid => a 1,2-saturated fatty acid + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15226", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49251", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429529", "l": "Thrombin binding to GP1b:IX:V (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11469", "l": "(S)-3-methyl-2-oxopentanoate + L-valine => 3-methyl-2-oxobutanoate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806629", "l": "Formation of tonofilament bundles (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74510", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14061", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) = glycine + H(+) + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.22", "l": "\"strombine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34084", "l": "a (3R)-3-hydroxyacyl-CoA => a (3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047646", "l": "alkanal monooxygenase (FMN-linked) activity", "d": ["Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62338", "l": "adenosine 3'-diphosphate,5'-phosphate + AMP + H(+) => AMP + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982637", "l": "Opsins binds G alpha-t (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25349", "l": "D-tyrosine + tRNA(Tyr) => D-tyrosyl-tRNA(Tyr) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19044", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015184", "l": "L-cystine transmembrane transporter activity", "d": ["Enables the transfer of L-cystine from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34843", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O = 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044684", "l": "dihydromethanopterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755303", "l": "26S proteasome degrades HIFalpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73262", "l": "cirsiliol + S-adenosyl-L-methionine <=> eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16098", "l": "acetylpyruvate + H2O => acetate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662466", "l": "XYLB phosphorylates D-xylulose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40242", "l": "ATP + CoA + dodecanedioate <=> AMP + diphosphate + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36760", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74161", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28701", "l": "Mn(2+)(out) => Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46762", "l": "4-methyl-5-nitrocatechol + NAD(+) + nitrite => 2,4-dinitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909726", "l": "Phosphorylation of STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48379", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47052", "l": "(2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54188", "l": "H2O + N-acetyl-L-phenylalanine = acetate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004141", "l": "dethiobiotin synthase activity", "d": ["Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71132", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) => H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035643", "l": "L-DOPA receptor activity", "d": ["Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28909", "l": "3-(3-hydroxyphenyl)propanoate(out) + H(+)(out) => 3-(3-hydroxyphenyl)propanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73457", "l": "8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010898", "l": "ROBO2 binds SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670673", "l": "FIX is secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17630", "l": "alpha,alpha-trehalose(in) => alpha,alpha-trehalose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667619", "l": "AVPR1A,B,2 bind atosiban (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114553", "l": "Activation of conventional Protein Kinase C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76535", "l": "FAD(in) = FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73290", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606839", "l": "ARSC hydrolyzes steroid sulfates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782655", "l": "HDAC10 deacetylates histone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035302", "l": "ecdysteroid 25-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018603", "l": "nitrobenzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14975", "l": "D-aspartate => L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19494", "l": "D-cellobiose + phosphate => alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33899", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": [], "t": []}, {"i": "EC:1.1.98.3", "l": "\"decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.2", "l": "\"ABC-type oligosaccharide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682020", "l": "MRN complex binds shortened telomeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190693", "l": "Synthesis of GJB1 (Cx32) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65205", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O => (R)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34116", "l": "carboxynorspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43486", "l": "1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432295", "l": "GPVI binds Fyn and Lyn (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56712", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.145", "l": "\"phosphatidylglycerol--prolipoprotein diacylglyceryl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928645", "l": "EPHB:NMDAR binds TIAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047573", "l": "4-acetamidobutyrate deacetylase activity", "d": ["Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48650", "l": "20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73580", "l": "(E,E)-piperoyl-AMP + CoA => (E,E)-piperoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691131", "l": "CANDI binds CUL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0050544", "l": "arachidonic acid binding", "d": ["Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33923", "l": "(1R,4R)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130504", "l": "Cleavage of lip22 to lip10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696183", "l": "AOC3 deaminates BZAM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56138", "l": "2 a phenolic radical donor + 2 H2O => 2 a phenolic donor + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793057", "l": "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044019", "l": "histone H3K72 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730862", "l": "Autophosphorylation of LYN kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH => 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679239", "l": "ULK complex translocates to the ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41836", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12503", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70883", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) = H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0140312", "l": "cargo adaptor activity", "d": ["Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0070888", "l": "E-box binding", "d": ["Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140506", "l": "endoplasmic reticulum-autophagosome adaptor activity", "d": ["The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54002", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.051624214255", "identifiers": [{"i": "GO:0016779", "l": "nucleotidyltransferase activity", "d": ["Catalysis of the transfer of a nucleotidyl group to a reactant."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141016", "l": "G/T mismatch-specific thymine-DNA glycosylase activity", "d": ["Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site."], "t": []}, {"i": "EC:3.2.2.29", "l": "\"thymine-DNA glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174438", "l": "Formation of the Flap Intermediate on the C-strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679266", "l": "Beclin-1 complex translocates to the ER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0019972", "l": "interleukin-12 binding", "d": ["Binding to interleukin-12."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509827", "l": "ITPA hydrolyses ITP to IMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36452", "l": "ATP + glycyl-L-glutamate(out) + H2O => ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674529", "l": "AAMP binds to TBXA2R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47458", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43092", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.208", "l": "\"23S rRNA (uridine(2479)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164840", "l": "ADP and Pi bind to ATPase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.168002017049517", "identifiers": [{"i": "GO:0140828", "l": "metal cation:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28009", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 <=> formaldehyde + H2O2 + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37842", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69140", "l": "RPA binds to the Flap (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77077", "l": "Capping complex formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19507", "l": "(indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42535", "l": "uridine(55) in tRNA <=> pseudouridine(55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35413", "l": "an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+) => (E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72729", "l": "UDP-alpha-D-glucuronate(out) + UMP(in) => UDP-alpha-D-glucuronate(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49906", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17240", "l": "ATP + FMN + H(+) <=> diphosphate + FAD", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22614", "l": "acetyl-CoA + pyruvate => (3S)-citramalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19341", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] = H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.3", "l": "\"alkane 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59325", "l": "D-xylose + O2 => D-xylono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661432", "l": "BIL binds ALB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33302", "l": "[eIF5A protein]-L-lysine + spermidine <=> [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374899", "l": "Release of noradrenaline  at the synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25298", "l": "acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69494", "l": "H2O2 + octanal => O2 + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73072", "l": "apigenin + S-adenosyl-L-methionine => genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69173", "l": "Joining of adjacent Okazaki fragments (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798257", "l": "PTPRS binds NTRK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982778", "l": "Growth hormone binds the growth hormone receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35809", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-D-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685604", "l": "SLAMF6 binds SLAMF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10300", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168947", "l": "Ligand binds to TLR10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74154", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46772", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.28", "l": "\"sn-1 stearoyl-lipid 9-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34409", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate => 3 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070051", "l": "fibrinogen binding", "d": ["Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354097", "l": "Activation of Talin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938389", "l": "RUNX1:CBFB binds the LGALS3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669302", "l": "p-BMAL1:p-CLOCK,NPAS2 binds RORA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350395", "l": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420911", "l": "Formation of PPAT dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106614", "l": "Duplex miRNA is loaded into Argonaute (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11688", "l": "ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": [], "t": []}, {"i": "EC:6.1.1.4", "l": "\"leucine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389762", "l": "Phosphorylation of PD-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952128", "l": "RUNX3 binds TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67674", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168376", "l": "STIM1 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44559", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate <=> 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75986", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) <=> (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0035515", "l": "oxidative RNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms."], "t": []}, {"i": "REACT:R-HSA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65290", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.43", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41286", "l": "H2O + N-tetracosanoyl-sphing-4-enine <=> sphing-4-enine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149519", "l": "MMACHC decyanates CNCbl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.312", "l": "\"D-glutamate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13174", "l": "H2O + NAD(+) + phosphonate => H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.28", "l": "\"L-cysteine desulfidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38668", "l": "sphing-4-enine 1-phosphate(in) => sphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35412", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside => an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.34", "l": "\"plasma kallikrein\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13086", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O => CoA + L-2-acetamido-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29668", "l": "H2O(in) => H2O(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59234", "l": "diphosphate + hydropyrenol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17843", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP => trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033838", "l": "flavonol-3-O-glucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878654", "l": "ACP6 hydrolyses MYS-LPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37209", "l": "1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22207", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15030", "l": "D-mannitol + NAD(+) => D-mannose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13119", "l": "3-(pyrazol-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + pyrazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65330", "l": "AH2 + chrodrimanin H => A + chrodrimanin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112727", "l": "Serine phosphorylation of STATs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35496", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate => 4-aminobenzoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362522", "l": "ALDHs oxidise atRAL to atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72538", "l": "H2O + NADP(+) + vanillin <=> 2 H(+) + NADPH + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429860", "l": "DCP1-DCP2 complex decaps mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876472", "l": "NPC2 binds CHOL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29677", "l": "glycerol(out) => glycerol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265301", "l": "Corticotropin cleavage from POMC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351201", "l": "N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873917", "l": "Translocation of STAT1 dimer to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9822539", "l": "VWF multimer binds to collagen type I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40045", "l": "ADP + beta-citrylglutamate + H(+) + phosphate => ATP + citrate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983424", "l": "Budding of COPII coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28904", "l": "D-alanine(in) + H(+)(in) => D-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71902", "l": "3',5'-cyclic GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21645", "l": "ATP + glycerol => ADP + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817575", "l": "ERO1B oxidizes P4HB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22761", "l": "Cypridina luciferin + O2 => CO2 + hnu + oxidized Cypridina luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689111", "l": "PARK2 autoubiquitinates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0022840", "l": "leak channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047458", "l": "beta-pyrazolylalanine synthase activity", "d": ["Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55952", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40578", "l": "glutaryl-CoA + H2O <=> CoA + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76561", "l": "ergosterol + H(+) + L-aspartate => 1-(ergostan-3beta-yl)-L-aspartate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694527", "l": "Loss of SAR1B GTPase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912627", "l": "CBL ubiquitinates PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68088", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] = a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38076", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449872", "l": "acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61066", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028598", "l": "Phosphorylation of YAP by LATS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047021", "l": "15-hydroxyprostaglandin dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848250", "l": "ACBD6 binds LCFA-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69112", "l": "glyoxylate + L-2-aminoadipate = 2-oxoadipate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18989", "l": "H(+) + L-valine = 2-methylpropan-1-amine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.14", "l": "\"valine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59230", "l": "6-sulfo-beta-D-quinovose => 6-sulfo-alpha-D-quinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66496", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432010", "l": "Aquaporin-1 passively transports water into cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085020", "l": "Cytosolic Neu5Ac translocates to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14388", "l": "a dolichyl diphosphate + H2O <=> a dolichyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035227", "l": "TXN2 binds CysS248-MPST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236963", "l": "Maturation of phagosome into phagolysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56113", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990984", "l": "tRNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71361", "l": "17beta-estradiol 17-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 17-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102418", "l": "luteolin-7-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786421", "l": "CHIA hydrolyses chitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39034", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052714", "l": "mannosyl-inositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21241", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036356", "l": "cyclic 2,3-diphosphoglycerate synthetase activity", "d": ["Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047006", "l": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27845", "l": "9H-carbazole + H(+) + NADPH + O2 <=> 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684043", "l": "Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706323", "l": "Active FLT3 binds to SLA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64520", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA = A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12795", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29602", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27508", "l": "benzoate + ecgonine methyl ester + H(+) => cocaine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22336", "l": "glycine betaine + L-homocysteine = L-methionine + N,N-dimethylglycine", "d": [], "t": []}, {"i": "EC:2.1.1.5", "l": "\"betaine--homocysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75846", "l": "ergothioneine(out) + Na(+)(out) <=> ergothioneine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102704", "l": "GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol = H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71690", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) <=> glycyl-L-aspartate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374896", "l": "Uptake of Noradrenaline (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25314", "l": "glycolate + O2 <=> glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497824", "l": "BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23361", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0090433", "l": "palmitoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA."], "t": []}, {"i": "REACT:R-HSA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167427", "l": "Opioid dissociates from MOR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806974", "l": "MET dimers autophosphorylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856945", "l": "PP2A methylation by LCMT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611851", "l": "ADRB2 bind ADR,NAd (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851076", "l": "p-T,Y MAPK8,9 bind TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067640", "l": "IL6 binds IL6R-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928607", "l": "p-EPHs bind VAV2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833820", "l": "PKR dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76913", "l": "3-methylcyclohexanone + H(+) + NADH + NH4(+) => (1S)-3-methyl-cyclohexylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340226", "l": "CYGB dioxygenates NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12684", "l": "creatinine + H(+) + H2O <=> N-methylhydantoin + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72085", "l": "ADP-alpha-D-ribose 1''-phosphate + H(+) => ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030165", "l": "PDZ domain binding", "d": ["Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44739", "l": "acetyl-CoA + dihydroxyacetone phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849463", "l": "PTK6 phosphorylates SFPQ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381668", "l": "cAMP activates EPAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64726", "l": "(7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.77", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38279", "l": "(3R)-citramalate + succinyl-CoA = (3R)-citramalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52285", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990808", "l": "F-bar domain binding", "d": ["Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60804", "l": "2-oxoglutarate + gibberellin A19 + O2 = CO2 + gibberellin A17 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53239", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75322", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) <=> chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682377", "l": "LC3 de-lipidation by ATG4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51358", "l": "(9Z)-octadecenoate + L-glutamine => H2O + N-(9Z-octadecenoyl)-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69770", "l": "(E)-non-2-enal + H2O + NAD(+) <=> (E)-non-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858252", "l": "HDLBP binds HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68576", "l": "ATP + H2O + xanthine(out) = ADP + H(+) + phosphate + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20551", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate => 2 Fe(III)-[cytochrome c] + 2 thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996727", "l": "REST recruits the BHC complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209168", "l": "Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76119", "l": "a dicarboxylate(in) + prostaglandin F2alpha(out) = a dicarboxylate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250875", "l": "botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754130", "l": "CDK4 inhibitors bind CDK4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995388", "l": "PP2A dephosphorylates BANF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17936", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903777", "l": "melibiose binding", "d": ["Binding to melibiose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954056", "l": "E2F6 binds TFDP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473186", "l": "FSTL3 binds Activin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438005", "l": "MKK4 phosphorylates JNK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28624", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315455", "l": "Defective CBLIF does not bind Cbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796617", "l": "MIB2 binds CFLAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061607", "l": "peptide alpha-N-propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655266", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77736", "l": "2 H2O + ITP => 2 H(+) + IMP + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606564", "l": "GALC hydrolyzes GalCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0004051", "l": "arachidonate 5-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857555", "l": "EGFR phosphorylates GPNMB (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49555", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] <=> H(+) + L-lysyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749197", "l": "ORC1 binds to H4K20me2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.98.-.-", "l": "\"ATP-independent chelatases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43184", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA = H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.312", "l": "\"25S rRNA (uracil(2843)-N(3))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39479", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001888", "l": "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77140", "l": "1D-myo-inositol 2,3-bisphosphate + H2O => 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61899", "l": "betaenone C <=> betaenone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23483", "l": "2-methylene-3-methylsuccinate <=> dimethylmaleate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34760", "l": "ATP + glycerol 2-phosphate(out) + H2O => ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626816", "l": "PIN1 binds p-S345-NCF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49184", "l": "chlorophyllide a + H(+) + H2O = 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.100", "l": "\"chlorophyllide a hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77167", "l": "AH2 + hercynyl-SeGlcNAc selenoxide = 2-acetamidoglucal + A + H2O + selenoneine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209840", "l": "Two DITs combine to form thyroxine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31154", "l": "H2O + L-selenocystathionine <=> 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70098", "l": "(R)-5-methyl-tetronate + o-quinone methide <=> peniphenone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784734", "l": "PCSK9 binds LDLR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32106", "l": "2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61889", "l": "diosgenin + UDP-alpha-D-glucose => diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193715", "l": "5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76263", "l": "ergothioneine(in) = ergothioneine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52613", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654603", "l": "Activated FGFR2 binds FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50104", "l": "taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59560", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone = H(+) + N,N',N''-triacetylchitotrionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62539", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607734", "l": "PKC-delta translocates to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376419", "l": "Formation of NR-MED1 Coactivator Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43097", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66427", "l": "ATP + H2O + leukotriene B4(in) <=> ADP + H(+) + leukotriene B4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40404", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664850", "l": "ATM binds PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033094", "l": "putrescine--2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69299", "l": "CDT1 binds geminin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731931", "l": "EDNRA binds selective ERAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56895", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose <=> NADP(+) + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40804", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83788", "l": "Binding of TFIIIC to Type 2 promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.8", "l": "\"hypoxanthine phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030773", "l": "6-hydroxymellein O-methyltransferase activity", "d": ["Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.374", "l": "\"2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41000", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31828", "l": "(2E,6E)-farnesyl diphosphate => (+)-gamma-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29111", "l": "H(+) + NADPH + ubiquinone-8 = NADP(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13951", "l": "NADPH + 2 oxidized [rubredoxin] => H(+) + NADP(+) + 2 reduced [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983158", "l": "Trimming of peptides in ER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27407", "l": "a ubiquinol + acetate + CO2 => a ubiquinone + H2O + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.67228564893351", "identifiers": [{"i": "GO:1990837", "l": "sequence-specific double-stranded DNA binding", "d": ["Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33469", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+) => 5-dehydroepisterol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948027", "l": "RNASEs bind bacterial phospholipids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14717", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.54", "l": "\"3-deoxy-7-phosphoheptulonate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0016851", "l": "magnesium chelatase activity", "d": ["Catalysis of the reaction: ATP + H2O + Mg2+ + protoporphyrin IX = ADP + 3 H+ + Mg-protoporphyrin IX + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032267", "l": "tRNA(Ile)-lysidine synthase activity", "d": ["Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762100", "l": "MYC- and NICD1-dependent NFE2L2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.2.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848250", "l": "ACBD6 binds LCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22927", "l": "dCMP + H(+) + H2O <=> dUMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71489", "l": "L-phenylalanyl-L-leucine + L-tyrosylglycylglycine => H2O + Leu-enkephalin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77008", "l": "(2S)-5,5-dimethylpiperidine-2-carboxylate + 10-hydroxy-pre-flavunoidine + ATP => AMP + diphosphate + flavunoidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58363", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17766", "l": "(2R)-3-phospho-glyceroyl phosphate => (2R)-2,3-bisphosphoglycerate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51059", "l": "A + androst-4-ene-3,17-dione <=> AH2 + androsta-1,4-diene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168459", "l": "Lyn activates ERK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44573", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) => 2-all-trans-heptaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679205", "l": "ULK1 phosphorylates Beclin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879562", "l": "SLCO2B1 has a narrow substrate specificity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72313", "l": "glutathione(out) + taurocholate(in) => glutathione(in) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928631", "l": "GIT1 binds bPIX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72806", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) <=> L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12407", "l": "D-glucose + UDP-alpha-D-galactose <=> H(+) + lactose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15505", "l": "(S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.291", "l": "\"2-hydroxymethylglutarate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65247", "l": "(2S)-hesperetin + UDP-alpha-D-glucose <=> (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010541", "l": "ISL1 binds the SLIT2 gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428909", "l": "Activated TP receptor binds G-protein  G13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36956", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA => (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56056", "l": "genistein + UDP-alpha-D-glucose = genistein 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64350", "l": "deacetylpyripyropene E => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29158", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) <=> 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018646", "l": "1-hydroxy-2-oxolimonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824216", "l": "MSGN1 binds the NOTCH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15157", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015654", "l": "tellurite transmembrane transporter activity", "d": ["Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112396", "l": "Separation of elongating transcript from template (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55281", "l": "13-cis-retinol + tetradecanoyl-CoA => 13-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009072", "l": "STAT3 phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36065", "l": "diphosphate + kunzeaol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53999", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661217", "l": "MT1A binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428918", "l": "Dissociation of the TP:G13 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034829", "l": "2-hydroxydec-2,4-diene-1,10-dioate hydratase activity", "d": ["Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32325", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034216", "l": "high-affinity thiamine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50543", "l": "prostaglandin A2 <=> prostaglandin C2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019162", "l": "pyridoxamine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34676", "l": "CTP + N,N-diacetyllegionaminate => CMP-N,N-diacetyllegionaminate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20591", "l": "(2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein] => glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46761", "l": "2,4-dinitrotoluene + NADH + O2 => 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42713", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA => 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49917", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55335", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine <=> a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018523", "l": "quinoline 2-oxidoreductase activity", "d": ["Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167113", "l": "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60867", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20055", "l": "D-ribulose + H(+) + NADH => NAD(+) + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44139", "l": "dodecanoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509831", "l": "ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610732", "l": "GSK3 phosphorylates p-GLI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688294", "l": "SIRT5 deacetylates Cytochrome C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398185", "l": "LARG binds plexin B1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.487982162555333", "identifiers": [{"i": "GO:0016758", "l": "hexosyltransferase activity", "d": ["Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.4.1.-", "l": "\"Hexosyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691154", "l": "HFE binds TFRC dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874718", "l": "TTPA binds alpha-TOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399711", "l": "Activation of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950218", "l": "Expression of Moesin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102427", "l": "allocryptopine 6-hydroxylase activity", "d": ["Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ = 6-hydroxy-allocryptopine + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682377", "l": "LC3 de-lipidation by ATG4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42116", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65504", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O = 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": [], "t": []}, {"i": "EC:3.4.14.14", "l": "\"[mycofactocin precursor peptide] peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5227009", "l": "ABCF1 binds EIF2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29662", "l": "O-acetyl-L-serine(in) <=> O-acetyl-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39260", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA => (2E,13Z)-docosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.30", "l": "\"pycnoporopepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051371", "l": "muscle alpha-actinin binding", "d": ["Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236970", "l": "Proteasomal clevage of exogenous antigen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001531", "l": "interleukin-21 receptor binding", "d": ["Binding to an interleukin-21 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686930", "l": "RIPK3 is cleaved by CASP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49577", "l": "AH2 + GTP + S-adenosyl-L-methionine => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070699", "l": "type II activin receptor binding", "d": ["Binding to a type II activin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806417", "l": "TP53 binds the DDB2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10655", "l": "a long-chain fatty aldehyde + H2O + NAD(+) <=> a long-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109860", "l": "MAP2K1 phosphorylates MAPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10072", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.161", "l": "\"dimethylglycine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65969", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34554", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine <=> ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45700", "l": "glycine betaine + H(+) + NADH + O2 = formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.251", "l": "\"glycine betaine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0008198", "l": "ferrous iron binding", "d": ["Binding to a ferrous iron ion, Fe(II)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27489", "l": "2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.28", "l": "\"D-sedoheptulose-7-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186780", "l": "PI3-kinase binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29523", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.131", "l": "\"GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17874", "l": "an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53273", "l": "5-dehydro-L-gluconate => keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65435", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016760", "l": "cellulose synthase (UDP-forming) activity", "d": ["Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102813", "l": "UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687095", "l": "p-S215 FOXO3 binds MIR34B and C gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654163", "l": "Activated FGFR4 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33504", "l": "ATP + H2O + itraconazole(in) => ADP + H(+) + itraconazole(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0015104", "l": "antimonite transmembrane transporter activity", "d": ["Enables the transfer of antimonite from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44357", "l": "nogalaviketone => methyl nogalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023980", "l": "18(S)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990254", "l": "keratin filament binding", "d": ["Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690493", "l": "RHOB binds effectors on endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34146", "l": "cannabinerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59153", "l": "ATP + CoA + pseudomonate C => AMP + diphosphate + pseudomonoyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928624", "l": "EPHBs bind EFNBs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080083", "l": "beta-gentiobiose beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67073", "l": "a very long-chain fatty acyl-CoA + H2O => a very long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45378", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72929", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV => O2 + proatranorin I + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27652", "l": "GDP + H(+) + UMP => GTP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247569", "l": "PADI4 deiminates Histones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57940", "l": "Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43967", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77075", "l": "(1R,4R,5S)-acoradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.70", "l": "\"pancreatic endopeptidase E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49735", "l": "H(+) + O2 + violaceinate <=> CO2 + H2O + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229132", "l": "AP4 binds APP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417843", "l": "P2Y13 binds ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53904", "l": "ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28353", "l": "UDP-beta-L-arabinofuranose <=> UDP-beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983285", "l": "RAD51B binds RAD51C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75286", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61993", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62516", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GA2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25604", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56170", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28507", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP => 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000319", "l": "BORA binds PLK1 and AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.432745995597372", "identifiers": [{"i": "GO:0015370", "l": "solute:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)."], "t": []}, {"i": "REACT:R-HSA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.156", "l": "\"oligosaccharide reducing-end xylanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39628", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-982765", "l": "Growth hormone forms dimers and oligomers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73449", "l": "acetyl-CoA(out) + AMP(in) => acetyl-CoA(in) + AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46314", "l": "3,22-dioxochol-4-en-24-oyl-CoA + CoA => 3-oxochol-4-en-22-oyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354173", "l": "Activation of Rap1 by cytosolic GEFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58678", "l": "H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide => NADPH + O2 + rifamycin SV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045353", "l": "interleukin-1 type II receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to interleukin-1 type II receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0005471", "l": "ATP:ADP antiporter activity", "d": ["Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047333", "l": "dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity", "d": ["Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373711", "l": "DCC interaction with Netrin-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28267", "l": "(2E,6E)-farnesyl diphosphate => (S)-beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57949", "l": "2-hydroxytoluene + H(+) + NADH + O2 => 3-methylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19698", "l": "11-cis-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77171", "l": "biocytin + H2O = biotin + L-lysine", "d": [], "t": []}, {"i": "EC:3.5.1.12", "l": "\"biotinidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174119", "l": "Free APC/C phosphorylated by Plk1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103107", "l": "castasterone 23-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: castasterone + UDP-alpha-D-glucose = castasterone-23-O-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018572", "l": "EGFR phosphorylates NOTCH3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44694", "l": "CoA + H(+) + N-acylhexadecasphinganine => a fatty acyl-CoA + hexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450494", "l": "HuR binds mRNAs in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834719", "l": "Synthesis of negative sense genomic RNA of respiratory syncytial virus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66856", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76355", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168909", "l": "viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42446", "l": "H(+) + iminosuccinate + NADPH => L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46272", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32419", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26221", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.145", "l": "\"abieta-7,13-dien-18-ol hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682010", "l": "ATG10:ATG12 binds ATG5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14741", "l": "4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.67", "l": "\"4-methyleneglutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607733", "l": "BCL10 binds CARD9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034523", "l": "3-formylsalicylate oxidase activity", "d": ["Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14469", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) = (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.32", "l": "\"aminomuconate-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45086", "l": "7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0035591", "l": "signaling adaptor activity", "d": ["The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75119", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70101", "l": "penilactone A => H(+) + o-quinone methide + peniphenone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858482", "l": "DVL is recruited to the receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48268", "l": "4',4'-dihydroxyechinenone = canthaxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944236", "l": "Association of procollagen type XIV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52331", "l": "L-arginine + O2 + reduced [flavodoxin] <=> H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23811", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689317", "l": "Formation of the pre-incision complex in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71950", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) <=> N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0003865", "l": "3-oxo-5-alpha-steroid 4-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769397", "l": "SOST binds LRP5/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656947", "l": "OGG1beta translocates to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375149", "l": "Interaction of NCAM1 with GFRalpha-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102511", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42166", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202164", "l": "Translocation of PDK1 to Plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66054", "l": "H2O + kynurenate + L-tryptophan => indole-3-pyruvate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73721", "l": "H(+) + S-adenosyl-L-homocysteine + vanillate => 3,4-dihydroxybenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831017", "l": "Expression of GREM1 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75620", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => ectocarpin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28181", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate <=> colnelenate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66824", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35565", "l": "(9Z)-hexadecenoate + ethanolamine => H2O + N-(9Z-hexadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61911", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol <=> 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445084", "l": "Phosphorylation of L1 by SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71493", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807106", "l": "PTEN undergoes monoubiquitination (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350769", "l": "trans-Golgi Network Coat Activation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63383", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016217", "l": "N-ethylammeline chlorohydrolase activity", "d": ["Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050092", "l": "meso-tartrate dehydrogenase activity", "d": ["Catalysis of the reaction: (2R,3S)-tartrate + NAD+ = dihydroxyfumarate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297444", "l": "Binding of cAMP to HCN channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5246478", "l": "APOM binds retinoids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17462", "l": "D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71606", "l": "2-oxoglutarate(out) + oxaloacetate(in) <=> 2-oxoglutarate(in) + oxaloacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090584", "l": "protein-phosphocysteine-galactitol-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14921", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.121", "l": "\"indole-3-acetate beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44368", "l": "Cr(6+) + 2 NADPH + O2 = Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901515", "l": "poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity", "d": ["Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40564", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63685", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP => (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31895", "l": "(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.104", "l": "\"alpha-humulene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12137", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11974", "l": "12 H(+) + 4 iron(III) oxide-hydroxide => 4 Fe(2+) + 6 H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24736", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde => 2-oxoglutarate + 4-hydroxybutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442387", "l": "ZIP8 mediates zinc influx into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59263", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17889", "l": "H2O + phosphoethanolamine = acetaldehyde + NH4(+) + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.2", "l": "\"ethanolamine-phosphate phospho-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696465", "l": "USP45 deubiquitinates ERCC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62476", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450474", "l": "MK2 phosphorylates BRF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427514", "l": "eNoSC deacetylates histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11849", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine => [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033950", "l": "xyloglucan-specific exo-beta-1,4-glucanase activity", "d": ["Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77103", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61408", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664346", "l": "IL10 gene produces IL10 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20383", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => androsterone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694611", "l": "nsp4 is glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113402", "l": "Formation of DSIF:NELF:early elongation complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77722", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64246", "l": "an N-(fatty acyl)-glycine + CoA + H(+) => a fatty acyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043761", "l": "archaetidylserine synthase activity", "d": ["Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP."], "t": []}, {"i": "EC:2.7.8.38", "l": "\"archaetidylserine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243938", "l": "AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17383", "l": "(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990276", "l": "RNA 5'-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467738", "l": "A2E translocates to RPE cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840795", "l": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821931", "l": "BOD1L1 binds SET1A complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22982", "l": "a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] => a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56016", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033738", "l": "methylenetetrahydrofolate reductase (ferredoxin) activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781941", "l": "WNTs are secreted in exosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10483", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate <=> 4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180008", "l": "RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 7) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.13", "l": "\"ornithine aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.76", "l": "\"L-iduronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013009", "l": "RHOA binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.-", "l": "\"In phosphorus-containing anhydrides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28231", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14887", "l": "ADP-D-ribose + L-arginyl-[protein] => H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611852", "l": "ADRB3 bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33488", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA => CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029468", "l": "Conversion of PA into DAG by PAP-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981610", "l": "Neuroglobin binds oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974731", "l": "Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40695", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol = 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102887", "l": "beta-sesquiphellandrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-sesquiphellandrene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052797", "l": "4-O-methyl-glucuronoyl methylesterase activity", "d": ["Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647977", "l": "ICMT methylates S-Farn RAS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71040", "l": "L-methionine(in) + L-phenylalanine(out) => L-methionine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19833", "l": "(6R)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.1.10", "l": "\"formyltetrahydrofolate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45117", "l": "(4R)-ipsdienol + NADP(+) => H(+) + ipsdienone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43392", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64429", "l": "glycyl-L-proline(out) + H(+)(out) => glycyl-L-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191656", "l": "Closure of gap junction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964513", "l": "E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-392834", "l": "Activation of EPACs by cAMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28582", "l": "ATP + dUDP = ADP + dUTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64277", "l": "chrysophanol-9-anthrone + O2 => chrysophanol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616116", "l": "EGR2 and SOX10 bind the MAG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870710", "l": "APP gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042901", "l": "arabinan transmembrane transporter activity", "d": ["Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606682", "l": "MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15822", "l": "2 A + glycine => 2 AH2 + CO2 + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58902", "l": "NH4(+) + urea-1,3-dicarboxylate => 1-carboxybiuret + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15796", "l": "bilirubin IXalpha + NADP(+) <=> biliverdin IXalpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12520", "l": "L-dopa = (E)-caffeate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.74", "l": "\"glycosaminoglycan galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52417", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) => CO2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222755", "l": "Peroxynitrite is reduced to nitrite by Tpx (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54147", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 <=> 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68069", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782893", "l": "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64815", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090471", "l": "9,15,9'-tri-cis-zeta-carotene isomerase activity", "d": ["Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0030613", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.20.-.-", "l": "\"Acting on phosphorus or arsenic in donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23864", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": [], "t": []}, {"i": "EC:4.6.1.12", "l": "\"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047782", "l": "coniferin beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374896", "l": "Uptake of Noradrenaline (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49458", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate => (2S)-2-amino-4-deoxychorismate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669158", "l": "NF2 binds PAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10242", "l": "a (2E)-enoyl-[ACP] + H(+) + NADH => a 2,3-saturated acyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428752", "l": "Dissociation of the TP:Gq complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37642", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54890", "l": "AMP + diphosphate + OPC8-CoA => (1S,2S)-OPC-8 + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61369", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O => 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63864", "l": "O2 + octadecanoate = (2R)-2-hydroperoxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66737", "l": "ATP + beta-citrylglutamate(in) + H2O => ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603297", "l": "Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18403", "l": "(S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65882", "l": "5alpha-androstan-1,3,17-trione + AH2 => 1-hydroxy-5alpha-androstan-3,17-dione + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32638", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47091", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29774", "l": "arsenate(in) + ATP + H2O <=> ADP + arsenate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49117", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-532549", "l": "MPI isomerises Fru6P to Man6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45798", "l": "acetoacetyl-CoA + H(+) + NADPH => (3R)-3-hydroxybutanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374298", "l": "Opioid receptors bind opioid peptides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65561", "l": "2-oxoglutarate + L-kynurenine => H2O + kynurenate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909720", "l": "IFN alpha/beta binds to IFNAR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73717", "l": "ATP(out) + dATP(in) => ATP(in) + dATP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18968", "l": "hydroxymethylbilane <=> H2O + uroporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706287", "l": "Active FLT3 binds to ABL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202489", "l": "Oligomerization of Bcl10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15809", "l": "(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.26", "l": "\"R-linalool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66571", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> preluffariellolide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.105", "l": "\"2-methylene-furan-3-one reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18119", "l": "H2O + L-dopaquinone => L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38396", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48340", "l": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.2", "l": "\"medium-chain acyl-CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69588", "l": "inosine + UMP = IMP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20287", "l": "alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41565", "l": "aklavinone + dTDP-beta-L-rhodosamine => aclacinomycin T + dTDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010856", "l": "adenylate cyclase activator activity", "d": ["Binds to and increases the activity of adenylate cyclase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67192", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34079", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102904", "l": "germacrene C synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015476", "l": "hemaglutinin autotransporter activity", "d": ["Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141673", "l": "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995334", "l": "COX15 transforms heme O to heme A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31055", "l": "estrone 3-sulfate + H2O = estrone + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70208", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) => sphinga-4E,14Z-dienine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73498", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine <=> an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54387", "l": "a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045486", "l": "naringenin 3-dioxygenase activity", "d": ["Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461993", "l": "pro-HD5 is cleaved by trypsin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004636", "l": "phosphoribosyl-ATP diphosphatase activity", "d": ["Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33260", "l": "4-aminoimidazole + H(+) + 2 H2O => N-formimidoylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45175", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10519", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) <=> (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617182", "l": "PRKACA phosphorylates PLN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724745", "l": "PLG(20-810) binds aprotinin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71270", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) <=> chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62916", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine = an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29805", "l": "ADP + H(+) + L-valine(in) + phosphate => ATP + H2O + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59357", "l": "H2O + lactobiono-1,5-lactone => H(+) + lactobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58807", "l": "5'-pApG-3' + H2O <=> 5'-ApG-3' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9842115", "l": "PSAP(195-273) dimer binds PE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54044", "l": "(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.169", "l": "\"7-epi-alpha-eudesmol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50692", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate = ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.342", "l": "\"alpha-maltose-1-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32915", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) = sn-glycero-3-phospho-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43899", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21749", "l": "(S)-lactaldehyde + NADP(+) => H(+) + methylglyoxal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186771", "l": "RNF111 binds SMAD7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44202", "l": "12-methyloctadecanoyl-CoA + AMP + diphosphate => 12-methyloctadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22391", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine <=> CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050284", "l": "sinapate 1-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52829", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 => (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781905", "l": "ZRANB1 binds APC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051500", "l": "D-tyrosyl-tRNA(Tyr) deacylase activity", "d": ["Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975633", "l": "atROL binds to RBP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021609", "l": "ESR-associated SRC autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47300", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75988", "l": "a dicarboxylate(in) + indoxyl sulfate(out) => a dicarboxylate(out) + indoxyl sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68295", "l": "L-seryl-[protein] + nonanoyl-CoA <=> CoA + O-nonanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.305790483933691", "identifiers": [{"i": "GO:0015605", "l": "organophosphate ester transmembrane transporter activity", "d": ["Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35033", "l": "L-serine(out) => L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805205", "l": "GPR35 binds kynurenic acid (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36874", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035978", "l": "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23561", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate => adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299318", "l": "Activation of TASK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52124", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68527", "l": "(2Z,6Z)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20028", "l": "gibberellin A3 + UDP-alpha-D-glucose <=> gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17575", "l": "H(+) + macrocin + S-adenosyl-L-homocysteine => demethylmacrocin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75696", "l": "2'-deoxycytidine(in) => 2'-deoxycytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617454", "l": "HOXB1 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693243", "l": "RHOD translocates to the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102979", "l": "homofuraneol oxidoreductase activity", "d": ["Catalysis of the reaction: homofuraneol + NADP = (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018689", "l": "naphthalene disulfonate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18315", "l": "benzaldehyde + hydrogen cyanide => (R)-mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76418", "l": "3',3'-cGAMP(out) + n H(+)(out) <=> 3',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55763", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid <=> an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49910", "l": "(R)-carnitine(in) + O-acetyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acetyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72276", "l": "oxalate(in) + sulfate(out) => oxalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760652", "l": "ILF3 binds CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59597", "l": "H2O + kynuramine + O2 => 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69489", "l": "O2 + tetradecan-1-ol => H2O2 + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57624", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75519", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 = (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53282", "l": "D-erythrulose => D-threose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76966", "l": "2-hexyl-5-heptylresorcinol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hexyl-5-(7-hydroxyheptyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69192", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39444", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433506", "l": "Phosphorylation of APS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112434", "l": "Formation of DSIF complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.81", "l": "\"flavone 7-O-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221843", "l": "MSR1 (SCARA1) binds collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19640", "l": "D-nopaline + H2O + NADP(+) <=> 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50771", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043831", "l": "thiosulfate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607733", "l": "BCL10 binds CARD9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27945", "l": "(3R)-3-hydroxy-D-aspartate <=> NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65986", "l": "lumisterol 3 => hnu + previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755765", "l": "C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13451", "l": "2-oxoglutarate + H(+) + NADH => 2-hydroxyglutarate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41112", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70991", "l": "H(+)(in) + L-mannopyranose(in) = H(+)(out) + L-mannopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676264", "l": "Formation of the SET1B complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32274", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> 4-methyl-2-oxopentanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0052706", "l": "histidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31239", "l": "4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58595", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36841", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395412", "l": "Phosphorylation of SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210290", "l": "Interaction of PECAM-1 and SHIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65653", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine => a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030783", "l": "[cytochrome c]-methionine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41662", "l": "NADH + sanguinarine => dihydrosanguinarine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634446", "l": "GFI1 gene expression is enhanced by CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71674", "l": "glycyl-L-glutamine(out) + H(+)(out) <=> glycyl-L-glutamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038006", "l": "netrin receptor activity involved in chemoattraction", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507875", "l": "Aquaporins passively transport urea into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74414", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50554", "l": "prostaglandin B1 => prostaglandin C1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58475", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47712", "l": "trans-3-hydroxy-L-proline = cis-3-hydroxy-D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801109", "l": "CHM binds RGGT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54404", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5333051", "l": "RPA1 binds HSF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102866", "l": "di-homo-gamma-linolenate delta5 desaturase activity", "d": ["Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor = arachidonate + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9817575", "l": "ERO1B oxidizes P4HB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21150", "l": "5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427337", "l": "MBD2 binds methylcytosine in chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15984", "l": "H(+) + S-adenosyl-L-methionine <=> CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15306", "l": "betaine aldehyde + H2O + NAD(+) => glycine betaine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44417", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684229", "l": "SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15929", "l": "2 H(+) + 2 H2O + methylenediurea = CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.21", "l": "\"methylenediurea deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34662", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40311", "l": "hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018807", "l": "RAC3 GDIs block activation of RAC3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450533", "l": "PKCdelta phosphorylates HuR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10275", "l": "a 1,2-diacyl-sn-glycerol + ATP <=> a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821395", "l": "PAXIP1 binds PAGR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70125", "l": "6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0061798", "l": "GTP 3',8'-cyclase activity", "d": ["Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.40", "l": "\"D-mannitol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53005", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683836", "l": "SFTPC gene produces pro-SFTPC protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70939", "l": "L-methionine(in) = L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251922", "l": "PLCG1 phosphorylation by p-EGFR:p-ERBB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030564", "l": "tRNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011074", "l": "LHX2 binds to ROBO1 gene locus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730858", "l": "Autophosphorylation of BTK/ITK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60339", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67273", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30898", "l": "H2O + O2 + propane-1,3-diamine <=> 3-aminopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75399", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) = 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682983", "l": "ATM phosphorylates WHSC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44451", "l": "an acyl-CoA + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76918", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NADP(+) <=> 3-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30025", "l": "pyridoxamine 5'-phosphate + pyruvate => L-alanine + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68914", "l": "DNA polymerase alpha:primase binds at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63732", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan O-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071950", "l": "FADH2 binding", "d": ["Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31817", "l": "(+)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72083", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O = ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56632", "l": "H2O + neryl diphosphate = 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60242", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49847", "l": "(-)-dehydrodiconiferyl acid + a quinone <=> (-)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654651", "l": "Activated FGFR4 binds FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18394", "l": "(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.18", "l": "\"aspergillopepsin I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61507", "l": "pelargonidin + UDP-alpha-D-glucose <=> pelargonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26047", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793472", "l": "RIPK3 binds p-S9-PRKN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944242", "l": "Association of procollagen type XXVII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134904", "l": "Phosphorylation of beta-catenin at Ser552 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869580", "l": "DEK binds TFAP2A homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806613", "l": "Keratin tetramers bind to form unit length filaments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48565", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O => D-ribose 5-phosphate + trans-zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67994", "l": "(Z)-1,2-dichloroethene + A + chloride + H(+) => AH2 + trichloroethene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75376", "l": "inosine(in) => inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33780", "l": "6-kestotriose + sucrose => 6,6-kestotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604732", "l": "Autocatalytic activation of proMMP13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20280", "l": "acetyl-CoA + an N-hydroxyarylamine <=> an N-acetoxyarylamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13699", "l": "ADP + D-ribose 5-phosphate + H(+) => ATP + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69428", "l": "arsenite + 3 glutathione + H(+) = arsenic triglutathione + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617179", "l": "PRKACA phosphorylates TNNI3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983156", "l": "Polyubiquitination of substrate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56502", "l": "CO2 + isopentenyl phosphate + phosphate => (R)-3,5-bisphosphomevalonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025890", "l": "Calcineurin binds NFATC1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186786", "l": "Autophosphorylation of PDGF beta receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16233", "l": "(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.169", "l": "\"2-dehydropantoate 2-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050260", "l": "ribose-5-phosphate-ammonia ligase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH4 = 5-phospho-D-ribosylamine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12115", "l": "indole-3-pyruvate + S-adenosyl-L-methionine <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56391", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14522", "l": "(2E)-geraniol + NADP(+) => (2E)-geranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18746", "l": "2 juglone + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68960", "l": "DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507875", "l": "Aquaporins passively transport urea into cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49912", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29754", "l": "acetoacetate(in) <=> acetoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29874", "l": "ATP + H2O + thiosulfate(out) <=> ADP + H(+) + phosphate + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56778", "l": "(+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.75", "l": "\"furin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985123", "l": "RNASEL binds 2'-5' oligoadenylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68377", "l": "glyoxylate + L-asparagine => 2-oxosuccinamate + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11035", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031854", "l": "orexigenic neuropeptide QRFP receptor binding", "d": ["Binding to an orexigenic neuropeptide QRFP receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75891", "l": "Abortive Initiation After Second Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13543", "l": "H(+) + sulfate + sulfur + thiosulfate => H2O + tetrathionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54370", "l": "acetoin + CO2 => acetaldehyde + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53393", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] => (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786567", "l": "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62212", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] = gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50968", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.34", "l": "\"tRNA(Ala)(adenine(37)) deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73635", "l": "CTP(out) + dGMP(in) = CTP(in) + dGMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0106346", "l": "snRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41188", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56457", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-fischerindole U", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75251", "l": "carminate + O2 = 3'-dehydrocarminate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68960", "l": "DNA polymerase epsilon binds at the origin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63792", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64348", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) = deacetylpyripyropene E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177930", "l": "GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56925", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651942", "l": "Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026510", "l": "NTF4-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37086", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine <=> [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72687", "l": "all-trans-retinol(out) = all-trans-retinol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14569", "l": "propane-1,2-diol = H2O + propanal", "d": [], "t": []}, {"i": "EC:4.2.1.28", "l": "\"propanediol dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54841", "l": "H(+) + NADPH + O2 + octan-3-one => H2O + NADP(+) + pentyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483174", "l": "PE is methylated to PC by PEMT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025890", "l": "Calcineurin binds NFATC1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58237", "l": "L-tyrosyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70839", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) = L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253319", "l": "ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14732", "l": "beta-D-fructose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65388", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0016168", "l": "chlorophyll binding", "d": ["Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58718", "l": "FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADH + rifampicin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106378", "l": "2-hydroxy-dATP hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551648", "l": "SUMOylation of TDG with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "56.168308473741043", "identifiers": [{"i": "GO:0140640", "l": "catalytic activity, acting on a nucleic acid", "d": ["Catalytic activity that acts to modify a nucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28915", "l": "4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73222", "l": "L-xylopyranose(out) + 2 Na(+)(out) <=> L-xylopyranose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174255", "l": "Degradation multiubiquitinated Cyclin A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24518", "l": "CoA + H(+) + N(2')-acetylgentamicin C1a => acetyl-CoA + gentamicin C1a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047387", "l": "serine-ethanolaminephosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + serine phosphoethanolamine = H+ + phosphoethanolamine + serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103085", "l": "2-(5'-methylthio)pentylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O = H+ + 2-(5'-methylthio)pentylmalate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684008", "l": "NBN binds KPNA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28623", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13577", "l": "a wax ester + H2O = a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.50", "l": "\"wax-ester hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38018", "l": "delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10753", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43061", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => beta-D-glucose 1-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750666", "l": "ALB binds ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917700", "l": "MVB Vesicle Formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45460", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786118", "l": "IL13 binds IL13RA:TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66943", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine <=> 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167427", "l": "Opioid dissociates from MOR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865774", "l": "TTLLs polyglutamylate tubulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31277", "l": "(S)-2-methyl-3-oxopropanoate + H(+) + NADH => (S)-3-hydroxy-2-methylpropanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17311", "l": "a phenol + acetate + H(+) => a phenyl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936068", "l": "H19 is cleaved to produce miR-675 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11753", "l": "acetylsalicylate + H2O => acetate + H(+) + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19057", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.12", "l": "\"phospholipid-hydroperoxide glutathione peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189069", "l": "sucrose + H2O => glucose + fructose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18557", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.105", "l": "\"alkylglycerophosphate 2-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352908", "l": "fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58348", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50737", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite => a quinol + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70364", "l": "cyanurate + H2O => 1-carboxybiuret + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69840", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043714", "l": "(R)-citramalate synthase activity", "d": ["Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22129", "l": "(1S,2R,4S)-borneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43047", "l": "hexadecasphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74716", "l": "Insulin binds the insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31635", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14181", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.8", "l": "\"trimethyllysine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030756", "l": "isoorientin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H+ + isoscoparin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60080", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030943", "l": "mitochondrion targeting sequence binding", "d": ["Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990882", "l": "CDK1 phosphorylates NUP98 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934446", "l": "Activated PKC phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0004560", "l": "alpha-L-fucosidase activity", "d": ["Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53760", "l": "allocholate + deoxycholoyl-CoA = allocholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514790", "l": "Elastin degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433454", "l": "Phosphorylation of GAB2 by SFKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48536", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423728", "l": "AFXBO translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832813", "l": "Expression of POU3F1 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48801", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202216", "l": "Phosphorylation of SLP-76 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676255", "l": "Formation of the MLL2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796626", "l": "MIB2 ubiquitinates CFLAR  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033812", "l": "3-oxoadipyl-CoA thiolase activity", "d": ["Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004446", "l": "inositol-hexakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877391", "l": "FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14293", "l": "D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75012", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate => 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69173", "l": "Joining of adjacent Okazaki fragments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25037", "l": "ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)", "d": [], "t": []}, {"i": "EC:2.7.1.164", "l": "\"O-phosphoseryl-tRNA(Sec) kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0043855", "l": "cyclic nucleotide-activated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66105", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49298", "l": "L-histidyl-[protein] + L-sorbose 1-phosphate(in) => keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69007", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite <=> AMP + cremeomycin + diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51985", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73718", "l": "UBF-1 Binds rDNA Promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174121", "l": "Association of Securin with Cdc20:APC/C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23974", "l": "(2E)-butenoyl-CoA + CO2 + Na(+)(out) => (2E)-glutaconyl-CoA + H(+) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74197", "l": "(5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate => aspulvinone E + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015444", "l": "P-type magnesium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033849", "l": "chrysanthemyl diphosphate synthase activity", "d": ["Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30462", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol <=> (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71159", "l": "H(+)(in) + L-serine(out) + Na(+)(out) = H(+)(out) + L-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033446", "l": "AGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938121", "l": "SERPINB13 binds CTSK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781897", "l": "USP11 deubiquitinates NFKBIA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759445", "l": "PREDN,PREDL diffuse into kidney cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61208", "l": "8-nitro-cGMP + L-cysteinyl-[protein] = H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709406", "l": "CO binds to Cytochrome c oxidase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710263", "l": "GZMB cleaves GSDME (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.59", "l": "\"glucan endo-1,3-alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734713", "l": "ORC6 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830754", "l": "GDNF from the metanephric mesenchyme binds RET:GFRA1 on the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381644", "l": "ER calcium channels open in response to activated PKA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22283", "l": "O-demethylpuromycin + S-adenosyl-L-methionine <=> H(+) + puromycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875816", "l": "STAT3 binds activated MET receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59537", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49056", "l": "asperlicin C + H(+) + NADPH + O2 = asperlicin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21688", "l": "a polyvinyl alcohol + n O2 = an oxidized polyvinyl alcohol + n H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.30", "l": "\"polyvinyl-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114684", "l": "Phosphorylation of Syntaxin-4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51103", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19728", "l": "H(+) + UDP-alpha-D-galacturonate <=> CO2 + UDP-beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351948", "l": "Mitochondrial recruitment of Drp1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035651", "l": "AP-3 adaptor complex binding", "d": ["Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189406", "l": "4 PBGs bind to form HMB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351849", "l": "Caspase-mediated cleavage of Etk (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173626", "l": "Activation of C1r (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004303", "l": "estradiol 17-beta-dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65767", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O <=> (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67158", "l": "(9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68801", "l": "H2O + nigerose => alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429449", "l": "Syk activation leads to SLP-76 activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.377736627990572", "identifiers": [{"i": "GO:0140674", "l": "ATP-dependent histone chaperone activity", "d": ["Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5669250", "l": "PAK1 phosphorylates FLNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48002", "l": "H2O2 + NADP(+) => 1,6-dihydro-beta-NADP + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26520", "l": "acryloyl-CoA + H2O => 3-hydroxypropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420243", "l": "GHRH receptor binds GHRH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30091", "l": "a ubiquinone + D-alanine + H2O = a ubiquinol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71291", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043877", "l": "galactosamine-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626549", "l": "IQGAPs bind CALM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23831", "l": "2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25148", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395320", "l": "Latent TGF-beta-1 binds integrins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694442", "l": "CNIH2,3 bind GRIA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65209", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O => (S)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54358", "l": "2-methylpropanal + CO2 => 3-methyl-2-oxobutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54643", "l": "(+)-copalyl diphosphate <=> (12E)-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0003882", "l": "CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183122", "l": "Factor D cleaves C3b-bound Factor B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102387", "l": "2-phenylethanol acetyltransferase activity", "d": ["Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48401", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66713", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70935", "l": "L-lysine(in) = L-lysine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17632", "l": "alpha,alpha-trehalose(in) <=> alpha,alpha-trehalose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49791", "l": "chenodeoxycholoyl-CoA + glycine <=> CoA + glycochenodeoxycholate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10034", "l": "[protein]-C-terminal-L-glutamate + NH4(+) => [protein]-C-terminal-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247569", "l": "PADI4 deiminates Histones (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30629", "l": "(2S)-2-acetolactate + H(+) + NADH => (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388833", "l": "Phosphorylation of CTLA-4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54748", "l": "ATP + CoA + firefly L-luciferin = AMP + diphosphate + L-firefly luciferyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.52", "l": "\"L-firefly luciferin--CoA ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46672", "l": "aldosterone + H(+) + NADPH = 5beta-dihydroaldosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140643", "l": "hydroxymethylglutaryl-CoA reductase (NADH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031761", "l": "fMet-Leu-Phe receptor binding", "d": ["Binding to a fMet-Leu-Phe receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389842", "l": "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34477", "l": "15-cis-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635868", "l": "ub-GLI is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12441", "l": "H2O + L-saccharopine + NAD(+) => 2-oxoglutarate + H(+) + L-lysine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419426", "l": "Cannabinoid receptors can bind cannabinoids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55569", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine => 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58869", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52549", "l": "L-threonate + NAD(+) => 2-dehydro-L-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952128", "l": "RUNX3 binds TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28940", "l": "H(+)(in) + xanthosine(in) => H(+)(out) + xanthosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44181", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48361", "l": "a 1,2-saturated fatty acid + H2O2 => a 2-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68838", "l": "(6R,7S)-himachala-9,11-diene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666001", "l": "Profilin:G-actin binds MKL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16342", "l": "(R)-5-phosphomevalonate + ATP => (R)-5-diphosphomevalonate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38768", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63198", "l": "(10bR,4aS)-oxomaritidine + NADP(+) => (10bR,4aS)-noroxomaritidine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798373", "l": "MDM2 ubiquitinates DYRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66739", "l": "ATP + beta-citrylglutamate(in) + H2O <=> ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39513", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23455", "l": "2'-deoxyadenosine + ATP <=> ADP + dAMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762333", "l": "ANGPTL4 binds to CDH11v (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160931", "l": "Disassembly of tight junctions (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047659", "l": "alpha-santonin 1,2-reductase activity", "d": ["Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42744", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.174", "l": "\"23S rRNA (guanine(1835)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22179", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432188", "l": "AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38752", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54425", "l": "L-aspartyl-[protein] + NAD(+) => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35377", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate => (beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0042288", "l": "MHC class I protein binding", "d": ["Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48955", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) <=> 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14233", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.52", "l": "\"2-acylglycerol-3-phosphate O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.5.-", "l": "\"Thiosulfotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814734", "l": "CDSN binds the cornified envelope (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29479", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-epicubenol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.64", "l": "\"(+)-epicubenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77035", "l": "(2S)-heptan-2-amine + H2O + NAD(+) = H(+) + heptan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64336", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA = 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74978", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] <=> a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55828", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110311", "l": "POLZ extends translesion synthesis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48224", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12290", "l": "an alcohol + L-fucose => an alpha-L-fucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36444", "l": "dihydrochanoclavine-I aldehyde => 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18494", "l": "benzoyl-CoA + glycine => CoA + H(+) + N-benzoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30789", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44952", "l": "(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30352", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate => 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850777", "l": "SPINK6 binds KLK14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46935", "l": "2-epi-5-epi-valiolone 7-phosphate <=> 5-epi-valiolone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247569", "l": "PADI4 deiminates Histones (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64889", "l": "ATP + holo-[ACP] + tetradecanoate => AMP + diphosphate + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951951", "l": "RUNX3 binds EP300 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22149", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] => a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72312", "l": "glutathione(in) + taurocholate(out) => glutathione(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419351", "l": "PAF receptor binds platelet activating factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73860", "l": "1-methylnicotinamide(out) => 1-methylnicotinamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035597", "l": "N6-isopentenyladenosine methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53678", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41174", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O <=> 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036393", "l": "thiocyanate peroxidase activity", "d": ["Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617064", "l": "SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39133", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9660557", "l": "RAS:GTP binds RAL GDS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27942", "l": "(3R)-3-hydroxy-D-aspartate = NH4(+) + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.3.1.27", "l": "\"threo-3-hydroxy-D-aspartate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30587", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide = 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25439", "l": "(2E,6E)-farnesyl diphosphate <=> (E,R)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.7", "l": "\"cellulose-polysulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047719", "l": "indole 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: indole + O2 = 2-formamidobenzaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174963", "l": "NAT1 acetylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010314", "l": "phosphatidylinositol-5-phosphate binding", "d": ["Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75326", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) <=> chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806629", "l": "Formation of tonofilament bundles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.42", "l": "\"FMN reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35678", "l": "H(+) + L-serine + tetradecanoyl-CoA <=> 3-oxohexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27753", "l": "2'-deoxyinosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16022", "l": "oxaloacetate => enol-oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835385", "l": "DUS2 binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61499", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688884", "l": "Defective CSF2RB does not bind SFTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3777129", "l": "HDAC3 containing complexes deacetylate histone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11320", "l": "UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose", "d": [], "t": []}, {"i": "EC:5.1.3.5", "l": "\"UDP-arabinose 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373134", "l": "succinate + CoASH + ATP <=> succinylCoA + ADP + Pi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42454", "l": "H2O + kynurenate => 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64936", "l": "dGTP + H2O = dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44703", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) <=> a (2E)-enoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362416", "l": "Frataxin binds iron (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50863", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65845", "l": "ADP(out) + H(+)(out) + phosphate(in) => ADP(in) + H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77232", "l": "cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + H2O => (S)-2-hydroxypropylphosphonate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53154", "l": "H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57001", "l": "acetyl-CoA + streptothricin F => CoA + H(+) + N(beta)-acetylstreptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42030", "l": "7-oxolithocholate + H(+) + NADH => NAD(+) + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038122", "l": "C-C motif chemokine 5 receptor activity", "d": ["Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51522", "l": "(S)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13683", "l": "a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902670", "l": "carbon dioxide binding", "d": ["Binding to carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944242", "l": "Association of procollagen type XXVII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180739", "l": "Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12105", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP => 7,8-dihydrofolate + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008964", "l": "phosphoenolpyruvate carboxylase activity", "d": ["Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674529", "l": "AAMP binds to TBXA2R (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046934", "l": "1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47297", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20269", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}, {"i": "EC:4.2.2.6", "l": "\"oligogalacturonide lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53965", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin => gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199203", "l": "PANK1/3 phosphorylate PanK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836404", "l": "p-PKR dimer phosphorylates MAPT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042907", "l": "xanthine transmembrane transporter activity", "d": ["Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797090", "l": "CCNK binds CDK12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.810482623587944", "identifiers": [{"i": "GO:0051213", "l": "dioxygenase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508451", "l": "PTK2B is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28041", "l": "[thioredoxin]-disulfide + dCDP + H2O <=> [thioredoxin]-dithiol + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674550", "l": "p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36360", "l": "2 a plastoquinone + 2 H2O + 4 hnu => 2 a plastoquinol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40496", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16101", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.5", "l": "\"chondroitin 4-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53258", "l": "7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76198", "l": "UDP-alpha-D-glucose(in) <=> UDP-alpha-D-glucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13241", "l": "ATP + L-fucose = ADP + beta-L-fucose 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.52", "l": "\"fucokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72014", "l": "glutathione(in) + urate(out) <=> glutathione(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029456", "l": "RAC1 and CDC42 activate PAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60743", "l": "(S)-(-)-citronellal + H2O + NADP(+) <=> (S)-(-)-citronellate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44617", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33763", "l": "a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+)", "d": [], "t": []}, {"i": "EC:1.3.1.38", "l": "\"trans-2-enoyl-CoA reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28065", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11738", "l": "6-oxocineole + H(+) + NADH => 2-exo-hydroxy-1,8-cineole + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38053", "l": "1-butanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70241", "l": "PCK1 phosphorylates OA to yield PEP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047229", "l": "13-hydroxydocosanoate 13-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58020", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = eupatolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683325", "l": "Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797269", "l": "Expression of HSPA8, ALOX15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0120296", "l": "peptide dopaminyltransferase activity", "d": ["Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)."], "t": []}, {"i": "RHEA:66556", "l": "dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48721", "l": "aurachin B + H2O + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61500", "l": "delphinidin + UDP-alpha-D-glucose = delphinidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21516", "l": "isopiperitenone = piperitenone", "d": [], "t": []}, {"i": "EC:5.3.3.11", "l": "\"isopiperitenone Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18159", "l": "ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39837", "l": "1-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009899", "l": "ent-kaurene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169828", "l": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112434", "l": "Formation of DSIF complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17208", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28948", "l": "H(+)(out) + L-arabinose(in) => H(+)(in) + L-arabinose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42271", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] <=> 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46540", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32598", "l": "7-isopropyl-4-methyloxepan-2-one + H2O <=> 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37884", "l": "acetyl-CoA + oxalate => acetate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71869", "l": "glycodeoxycholate(in) => glycodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186786", "l": "Autophosphorylation of PDGF beta receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0032453", "l": "histone H3K4 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55849", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203977", "l": "SAR1 Activation And Membrane Binding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948027", "l": "RNASEs bind bacterial phospholipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73650", "l": "CTP(out) + IMP(in) <=> CTP(in) + IMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33942", "l": "H(+) + L-arginine + NADH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035966", "l": "Defective GGT1 does not hydrolyse GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034860", "l": "2-mercaptobenzothiazole desulfurase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156930", "l": "GTP-binding activates eEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37882", "l": "methyl aklanonate <=> aklaviketone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17614", "l": "NAD(+) + scyllo-inositol => H(+) + NADH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57090", "l": "3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+) => an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55577", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine => H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830951", "l": "NPNT from the nephric duct binds ITGA8 on the metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12529", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate => [hyaluronan](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63994", "l": "5-fluorocytidine 5'-phosphate + ADP + H(+) => 5-fluorocytidine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67527", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39572", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63167", "l": "H2O + N-tricosanoyl-taurine <=> taurine + tricosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809309", "l": "MTMR6 binds MTMR9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990002", "l": "methylglyoxal reductase (NADPH-dependent, acetol producing)", "d": ["Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55117", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40476", "l": "1,2,3-tributanoylglycerol + H2O => butanoate + dibutanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21036", "l": "2 acetyl-CoA = acetoacetyl-CoA + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.9", "l": "\"acetyl-CoA C-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807872", "l": "Active ARF recruits coatomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74068", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42468", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14655", "l": "a nucleoside 5'-phosphate + H(+) => a nucleoside 3',5'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035514", "l": "Defective ALG9 does not add the last mannose to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65055", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) <=> 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62354", "l": "H2O + NADP(+) + notoamide D => H(+) + NADPH + notoamide E + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41179", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018804", "l": "RAC3 GEFs activate RAC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51463", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate <=> (9Z)-octadecenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928600", "l": "N-WASP binds ITSN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45742", "l": "5-hydroxyectoine + CO2 + succinate => 2-oxoglutarate + L-ectoine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31285", "l": "dihydroxyacetone phosphate + FADH2 => FAD + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198813", "l": "GSTO dimers reduce DeHA to AscH- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33849", "l": "(4R)-hydroxysphinganine + tetracosanoate => H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29139", "l": "2 H(+)(in) + menaquinol-8 + nitrate = 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203774", "l": "Interaction of Csk with PAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964550", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662620", "l": "MT3 binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008454", "l": "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55695", "l": "an inositol-1-phosphoceramide + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507875", "l": "Aquaporins passively transport urea into cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051908", "l": "double-stranded DNA 5'-3' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule."], "t": []}, {"i": "EC:3.1.11.3", "l": "\"exodeoxyribonuclease (lambda-induced)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874979", "l": "ACBD3 binds GOLGB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694527", "l": "Loss of SAR1B GTPase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62671", "l": "deoxyherqueinone + H(+) + NADPH + O2 <=> H2O + herqueinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20897", "l": "ATP + hydrogencarbonate + urea => ADP + H(+) + phosphate + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28210", "l": "H2O + L-saccharopine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": [], "t": []}, {"i": "EC:1.5.3.18", "l": "\"L-saccharopine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40359", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13755", "l": "2-oxoglutarate + H(+) + L-glutamine + NADH => 2 L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12886", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) => GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354124", "l": "Phosphorylation of pPTK2 by SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40529", "l": "2 a ubiquinone + 4 H(+)(out) + 2 H2O(in) => 2 a ubiquinol + 4 H(+)(in) + O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043763", "l": "UTP:glucose-1-phosphate uridylyltransferase regulator activity", "d": ["Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853762", "l": "RET dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38955", "l": "an N-acylsphing-4-enine 1-phosphate(in) = an N-acylsphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61465", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.582265651609575", "identifiers": [{"i": "GO:0019763", "l": "immunoglobulin receptor activity", "d": ["Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102210", "l": "rhamnogalacturonan endolyase activity", "d": ["Catalysis of the reaction: H2O + a rhamnogalacturonan type I = [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9676257", "l": "Formation of the SET1A complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21189", "l": "ATP + deamido-NAD(+) + NH4(+) => AMP + diphosphate + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839114", "l": "BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37398", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34691", "l": "(R)-lactoyl-CoA = acryloyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.54", "l": "\"lactoyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57503", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13415", "l": "AMP + dTMP + H(+) => ADP + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963915", "l": "1,25(OH)2D binds VDR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60040", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate = (2E)-3-methylhex-2-enoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016402", "l": "pristanoyl-CoA oxidase activity", "d": ["Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16397", "l": "2 D-glucopyranose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate", "d": [], "t": []}, {"i": "EC:2.7.1.41", "l": "\"glucose-1-phosphate phosphodismutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49546", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29414", "l": "glycolate(in) + H(+)(in) <=> glycolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64130", "l": "L-phenylalanine + octadecanoate => H2O + N-octadecanoyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437234", "l": "Heat-Stable Antigen binds L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28013", "l": "propanoyl-CoA + succinate <=> propanoate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39350", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464822", "l": "RDH12 reduces atRAL to atROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-976801", "l": "Complement factor I complex formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53707", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63229", "l": "ATP + spectinomycin => 9-O-adenylylspectinomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627870", "l": "SLC26A4 does not transport I- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35741", "l": "4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone => cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.301331245594", "identifiers": [{"i": "GO:0003729", "l": "mRNA binding", "d": ["Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876484", "l": "NPC2 transfers CHOL to NPC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12168", "l": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.54", "l": "\"allyl-alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53150", "l": "H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679266", "l": "Beclin-1 complex translocates to the ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034893", "l": "N-nitrodimethylamine hydroxylase activity", "d": ["Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45670", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57649", "l": "S-adenosyl-L-methionine + trichosetin => equisetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033292", "l": "NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42319", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9833635", "l": "p-PKR dimer localizes to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69940", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114684", "l": "Phosphorylation of Syntaxin-4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001049", "l": "RNA polymerase V core binding", "d": ["Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031176", "l": "endo-1,4-beta-xylanase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16673", "l": "3-phosphonopyruvate + H2O = H(+) + phosphate + pyruvate", "d": [], "t": []}, {"i": "EC:3.11.1.3", "l": "\"phosphonopyruvate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218821", "l": "PDK1 phosphorylates PKC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632182", "l": "PRMT1 methylates ESRs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24232", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.127", "l": "\"2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50897", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O => (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197958", "l": "FPGS-2 transforms THF to THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73486", "l": "D-lysine(in) + L-ornithine(out) <=> D-lysine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32549", "l": "(1R,5R)-sabinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47027", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852337", "l": "GTSE1 binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49759", "l": "H(+) + O2 + protoviolaceinate <=> CO2 + H2O + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53323", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54250", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47460", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA = (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070260", "l": "5'-tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50345", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH => 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672948", "l": "MARK3 phosphorylates KSR1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943279", "l": "GGT dimers hydrolyse GSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75555", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] = erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874849", "l": "CREBRF binds CREB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944261", "l": "Association of procollagen type XIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46185", "l": "3-methylbutanoate + ATP + CoA => 3-methylbutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139920", "l": "Translocation of tBID to mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26554", "l": "angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine", "d": [], "t": []}, {"i": "EC:3.4.17.23", "l": "\"angiotensin-converting enzyme 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72053", "l": "butanoate(in) + estrone 3-sulfate(out) => butanoate(out) + estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64016", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201630", "l": "Caspase-mediated cleavage of Acinus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18062", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran => methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13478", "l": "H2O + L-tryptophan + NADP(+) => H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72248", "l": "(R)-noradrenaline + S-adenosyl-L-methionine => (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964567", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40788", "l": "H2O + tetracosanoyl-CoA => CoA + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.-", "l": "\"Amide--thiol ligases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43379", "l": "5'-deoxyinosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.123", "l": "\"[cytochrome c]-methionine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704408", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48561", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate => D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928640", "l": "PAKs phosphorylate MLC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704248", "l": "CHRM4 binds CHRM4 antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035527", "l": "3-hydroxypropionate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69452", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75078", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807872", "l": "Active ARF recruits coatomer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45323", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine <=> H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61875", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0019117", "l": "dihydroxyfluorene dioxygenase activity", "d": ["Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031735", "l": "CCR10 chemokine receptor binding", "d": ["Binding to a CCR10 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682695", "l": "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004787", "l": "thiamine diphosphate phosphatase activity", "d": ["Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate."], "t": []}, {"i": "RHEA:27998", "l": "H2O + thiamine diphosphate = H(+) + phosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17314", "l": "ATP + L-histidine + tRNA(His) => AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21908", "l": "NADP(+) + scytalone = H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}, {"i": "EC:1.1.1.252", "l": "\"tetrahydroxynaphthalene reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75066", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085992", "l": "SUMOylation of DAXX with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631885", "l": "PRDX1 overoxidizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37362", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34641", "l": "H2O + NADP(+) + neopentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015188", "l": "L-isoleucine transmembrane transporter activity", "d": ["Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35603", "l": "beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37836", "l": "aklavinone + H(+) + NADPH + O2 => epsilon-rhodomycinone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210309", "l": "Interaction of DAP12 and KIR2DS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29895", "l": "ATP + H2O + L-glutamine(out) = ADP + H(+) + L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20853", "l": "ATP + H(+)(in) + H2O => ADP + 2 H(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56210", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54060", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.187", "l": "\"(2Z,6E)-hedycaryol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44762", "l": "6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675206", "l": "PEA15 binds MAPK monomers and dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015495", "l": "gamma-aminobutyric acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)."], "t": []}, {"i": "REACT:R-HSA-428625", "l": "Vesicular inhibitory amino acid transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036127", "l": "3-sulfino-L-alanine binding", "d": ["Binding to 3-sulfino-L-alanine (cysteine sulfinate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12860", "l": "(2S,3S)-3-methyl-L-aspartate <=> L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17549", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.16", "l": "\"methylene-fatty-acyl-phospholipid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.169", "l": "\"protein O-GlcNAcase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40712", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34345", "l": "4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone => (20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814555", "l": "Integrator complex processes the 3' end of snRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70030", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13890", "l": "FAD + H2O => AMP + FMN + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50210", "l": "cortisone + H(+) + NADH => cortisol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295632", "l": "PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031774", "l": "leukotriene receptor binding", "d": ["Binding to a leukotriene receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28459", "l": "biotin(in) => biotin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473584", "l": "Collagen type III degradation by MMP15 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832850", "l": "Expression of PAX6 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1364044", "l": "PRLR:JAK2 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63110", "l": "ascofuranol => 16-hydroxy-ilicicolin A epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67321", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate => sch 210971", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45055", "l": "(2E)-butenoyl-CoA + (R)-carnitine <=> CoA + O-(2E)-butenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12306", "l": "2 H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788061", "l": "Fibronectin degradation by ADAM8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004113", "l": "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851298", "l": "GPR143 binds L-Dopa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828719", "l": "L mRNA is translated into protein L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42734", "l": "N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(527) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39503", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39231", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH = (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55787", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15999", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+) => anthraniloyl-CoA + 2 H(+) + 2 NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.157025479615683", "identifiers": [{"i": "GO:0003994", "l": "aconitate hydratase activity", "d": ["Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0016984", "l": "ribulose-bisphosphate carboxylase activity", "d": ["Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014343", "l": "IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110307", "l": "REV1 binds AP-dsDNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23576", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.66", "l": "\"berbamunine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.6", "l": "\"hydroxyacylglutathione hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31513", "l": "chenodeoxycholate + CoA + H(+) => chenodeoxycholoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70506", "l": "H2O + isopentenyl diphosphate <=> H(+) + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016971", "l": "flavin-dependent sulfhydryl oxidase activity", "d": ["Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins."], "t": []}, {"i": "RHEA:59116", "l": "[protein]-dithiol + O2 = [protein]-disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709883", "l": "BIL:ALB scavenges O2.- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13539", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106371", "l": "fluorescent chlorophyll catabolite monooxygenase (deformylase) activity", "d": ["Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite."], "t": []}, {"i": "RHEA:67172", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28824", "l": "H(+)(in) + L-galactonate(in) => H(+)(out) + L-galactonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68039", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372542", "l": "Loading of dopamine into synaptic veiscles (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32825", "l": "phosphate(out) => phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29936", "l": "cytosine(in) + H(+)(in) => cytosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51297", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66152", "l": "acetyl-CoA + noradrenaline = CoA + H(+) + N-acetylnoradrenaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53597", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35149", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419841", "l": "Light stimulates opsin receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32856", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193761", "l": "25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43717", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate => [glutamine synthetase]-L-tyrosine + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24139", "l": "3'-phosphoadenylyl sulfate + a primary amine <=> a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682863", "l": "RNF168 binds DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32462", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38330", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818495", "l": "UHRF1:DPPA3 translocates from the nucleoplasm to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24511", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.201143870267188", "identifiers": [{"i": "GO:0003682", "l": "chromatin binding", "d": ["Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.923594617603442", "identifiers": [{"i": "GO:0004096", "l": "catalase activity", "d": ["Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75015", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210805", "l": "Removal of miRNA passenger strand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.41723220320425", "identifiers": [{"i": "GO:0016881", "l": "acid-amino acid ligase activity", "d": ["Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.3.2.-", "l": "\"Acid--amino-acid ligases (peptide synthases)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912352", "l": "Galactosylation of Pre-NOTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213207", "l": "Formation of collagen networks (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31367", "l": "2 H(+) + 3 nitrite = H2O + nitrate + 2 nitric oxide", "d": [], "t": []}, {"i": "EC:1.7.6.1", "l": "\"nitrite dismutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26006", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate = beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16660", "l": "H2O + inosine <=> D-ribose + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10723", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10604", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}, {"i": "EC:3.1.4.3", "l": "\"phospholipase C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34057", "l": "6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH => festuclavine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69407", "l": "uracil(in) <=> uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5228992", "l": "ROCK1,ROCK2 are activated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864577", "l": "TFAP2C translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008447", "l": "L-ascorbate oxidase activity", "d": ["Catalysis of the reaction: 4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16917", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.10", "l": "\"2,6-dihydroxypyridine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29453", "l": "H2 + phosphate => H2O + phosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47200", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15174", "l": "H(+) + H2O2 + NADPH => 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69983", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20133", "l": "3-(indol-3-yl)lactate + NAD(+) = H(+) + indole-3-pyruvate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700154", "l": "Active ALK binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45943", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43632", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.498354445609536", "identifiers": [{"i": "GO:0043177", "l": "organic acid binding", "d": ["Binding to an organic acid, any acidic compound containing carbon in covalent linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30218", "l": "a menaquinol + 2 nitric oxide <=> a menaquinone + H2O + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010815", "l": "SLITs bind keratan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0030368", "l": "interleukin-17 receptor activity", "d": ["Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26460", "l": "acetaldehyde + FMN + 2 H(+) + H2O + nitrite => ethylnitronate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53413", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850945", "l": "Casein kinase II phosphorylates PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63669", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42824", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 = H2O + 2 NAD(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368065", "l": "Expression of NPAS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592278", "l": "Autocatalytic activation of proMMP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64481", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32923", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15554", "l": "1D-myo-inositol 1,4-bisphosphate + H2O => 1D-myo-inositol 4-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193068", "l": "CYP17A1 17-hydroxylates PREG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016979", "l": "lipoate-protein ligase activity", "d": ["Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634834", "l": "ACHEIs bind ACHE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193997", "l": "CYP11B1 oxidises 11DCORT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16538", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O => (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66508", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857686", "l": "FITM1, FITM2 bind TAGs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70653", "l": "H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein] => (9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802926", "l": "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49908", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24640", "l": "ergosteryl 3-beta-D-glucoside + H2O = D-glucose + ergosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314686", "l": "ASA- acetylates PTGS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24969", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22956", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.77", "l": "\"plasmanylethanolamine desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635848", "l": "GLI proteins bind PTCH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626928", "l": "CREBBP binds FOXO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983422", "l": "Disassembly of COPII coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419269", "l": "TSFM binds TUFM displacing GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008684", "l": "TBK1 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682626", "l": "nsp13 binds nsp12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72290", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624120", "l": "CEBPA binds CDK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2512800", "l": "SCARB1:ligand is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54729", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54736", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47061", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38840", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015351", "l": "bilirubin secondary active transmembrane transporter activity", "d": ["Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30735", "l": "1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37740", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35384", "l": "precorrin-6B + S-adenosyl-L-methionine => CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944250", "l": "Association of procollagen type XXV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68340", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56474", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37848", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 => daunorubicin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002172", "l": "high-affinity IgM receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362522", "l": "ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74707", "l": "Binding of IRS to insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67725", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) => CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444100", "l": "PROT mediates L-proline uptake (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9669893", "l": "KIT binds type I TKIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10974", "l": "alpha-D-hexose 1-phosphate + NH4(+) => D-hexose + H(+) + phosphoramidate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482772", "l": "Release of platelet cytosolic components (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690873", "l": "ACO1 binds 4Fe-4S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028260", "l": "δ12-PGJ3 spontaneously dehydrates to  15d-PGJ3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159253", "l": "MMAB adenosylates cob(I)alamin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52684", "l": "NAD(+) + pyridoxine = H(+) + NADH + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41707", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27274", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22087", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928632", "l": "ITSN1 exchanges GTP for GDP on CDC42, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0045119", "l": "azole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854981", "l": "SHC1 in the RET complex is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31282", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912396", "l": "NICD1 binds HIF1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27785", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate <=> 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72962", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) <=> (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61587", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948027", "l": "RNASEs bind bacterial phospholipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112042", "l": "Opioid binds MOR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34337", "l": "(22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12947", "l": "biphenyl-2-ol + H(+) + sulfite => 2'-hydroxybiphenyl-2-sulfinate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018665", "l": "4-hydroxyphenylacetate 1-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3782655", "l": "HDAC10 deacetylates histone (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674529", "l": "AAMP binds to TBXA2R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69408", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) = androst-4-ene-3,11,17-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624952", "l": "Assembly of the retrograde IFT train (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21135", "l": "H2O + O2 + xanthine <=> H2O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69120", "l": "glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170986", "l": "Ral-GDS binds to Ras-GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64448", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.370", "l": "\"[histone H3]-lysine(4) N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11238", "l": "propane-1,3-diamine + sym-homospermidine => putrescine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34370", "l": "acrylamide + H2O <=> acrylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36483", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050270", "l": "S-adenosylhomocysteine deaminase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O + H+ = S-inosyl-L-homocysteine + NH4."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56522", "l": "2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine => Fe-coproporphyrin III + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11229", "l": "(2S)-flavan-4-ol + NADP(+) => (2S)-flavanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714483", "l": "RAC2 translocates to the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33029", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67658", "l": "2 Fe(II)-[cytochrome c] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33953", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP => ribostamycin + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41528", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH = NAD(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22638", "l": "dCMP + diphosphate + H(+) => dCTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675417", "l": "PEBP1 binds activated RAF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022764", "l": "SGK1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16949", "l": "myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose", "d": [], "t": []}, {"i": "EC:1.1.1.18", "l": "\"inositol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61853", "l": "campesterol + UDP-alpha-D-glucose => campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869568", "l": "NPM1 binds TFAP2A homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61742", "l": "H(+) + steviolbioside + UDP => steviolmonoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090079", "l": "GLB1 hydrolyses linker chain(2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42665", "l": "alpha-L-arabinopyanose + NADP(+) => H(+) + L-arabinono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41931", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013109", "l": "RHOC GEFs activate RHOC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50704", "l": "1-propanol + NAD(+) = H(+) + NADH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65331", "l": "A + chrodrimanin F <=> AH2 + chrodrimanin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40313", "l": "(2E)-hexenoyl-CoA + H2O2 => hexanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19724", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631941", "l": "SESN1,2,3 bind AMPK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047313", "l": "aromatic-amino-acid-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035379", "l": "carbon dioxide transmembrane transporter activity", "d": ["Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45597", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18857", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.138", "l": "\"lithocholate 6beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68255", "l": "L-tryptophan(in) + Na(+)(in) <=> L-tryptophan(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004504", "l": "peptidylglycine monooxygenase activity", "d": ["Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062187", "l": "anandamide 8,9 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:53140", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20104", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] <=> AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0001058", "l": "RNA polymerase V activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42708", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.33", "l": "\"tRNA (guanine(46)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76370", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090079", "l": "GLB1 hydrolyses linker chain(2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448744", "l": "IL20RA binds IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37304", "l": "ATP + glycyl-L-asparagine(out) + H2O => ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033208", "l": "UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17551", "l": "1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952371", "l": "MDM2 binds RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33050", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635859", "l": "GLI:SUFU dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31387", "l": "(S)-2,3-epoxysqualene = alpha-amyrin", "d": [], "t": []}, {"i": "EC:5.4.99.40", "l": "\"alpha-amyrin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46955", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33337", "l": "1,2-dioctadecanoyl-sn-glycerol + phosphate => 1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28896", "l": "cadaverine(in) + L-lysine(out) => cadaverine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10518", "l": "(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH => (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28557", "l": "D-mannose 6-phosphate + H2O <=> D-mannose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665761", "l": "FMNL3 binds RHOC:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678925", "l": "NR3C1 binds NR3C1 agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48987", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28943", "l": "glycine betaine(in) = glycine betaine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031894", "l": "V1A vasopressin receptor binding", "d": ["Binding to a V1A vasopressin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33250", "l": "O2 + putrescine <=> 1-pyrroline + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34887", "l": "selenate(in) = selenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47597", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74740", "l": "Binding of SHC1 to insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29593", "l": "H(+) + NADPH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19744", "l": "formyl-CoA + H2O <=> CoA + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70375", "l": "3-oxosphinganine + dodecanoyl-CoA = CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44239", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42390", "l": "beta-D-gentiobiosyl crocetin + H(+) + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15053", "l": "(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}, {"i": "EC:2.1.2.2", "l": "\"phosphoribosylglycinamide formyltransferase 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033727", "l": "aldehyde dehydrogenase (FAD-independent) activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16338", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444661", "l": "HCAR2 binds HCAR2 ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0140272", "l": "exogenous protein binding", "d": ["Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419843", "l": "CALCA(83-119) binds CALCR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67012", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.50", "l": "\"mRNA guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9834807", "l": "ILF3 binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25124", "l": "(S)-2-amino-6-oxohexanoate <=> H(+) + H2O + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139917", "l": "tBID activates BAX protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70250", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose <=> beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.19", "l": "\"glutamyl endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626938", "l": "Beta-catenin binds SOX proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.024897738786478", "identifiers": [{"i": "GO:0060589", "l": "nucleoside-triphosphatase regulator activity", "d": ["Binds to and modulates the activity of an NTPase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22795", "l": "isonocardicin A <=> nocardicin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15660", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) <=> 3-methylcatechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4837364", "l": "Secretion of SOD3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673789", "l": "Activated JNK phosphorylates c-JUN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.25", "l": "\"carvone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29256", "l": "Ca(2+)(in) + Na(+)(out) => Ca(2+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685607", "l": "Sialic acid binds SIGLEC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167415", "l": "G-protein alpha subunit is inactivated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168038", "l": "Collagen type XV restin release (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65268", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 = chrodrimanin F + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39276", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH => (15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29388", "l": "CTP + H2O => CDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43957", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65704", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose = alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15818", "l": "H2O + O2 + pyridoxamine 5'-phosphate => H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24406", "l": "acetoacetate + acetyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55820", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31240", "l": "4 H(+) + uroporphyrinogen I => 4 CO2 + coproporphyrinogen I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381799", "l": "Synthesis of Preproglucagon in intestinal L cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62623", "l": "[thioredoxin]-dithiol + a hydroperoxide <=> [thioredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57508", "l": "H2O + NADP(+) + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.52", "l": "\"staphylopine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49364", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693478", "l": "HTR1A binds HTR1A agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52446", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43681", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766608", "l": "PRMT1 binds type I PRMT inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451461", "l": "IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964280", "l": "Active Gq binds BTK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45079", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61756", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453183", "l": "p-Y348-SYK dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0120227", "l": "acyl-CoA binding", "d": ["Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042349", "l": "guiding stereospecific synthesis activity", "d": ["The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71783", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31425", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033409", "l": "UAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165195", "l": "GTP loading by Rheb (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75232", "l": "H2O + L-galactono-1,4-lactone => H(+) + L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626938", "l": "Beta-catenin binds SOX proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56471", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684008", "l": "NBN binds KPNA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607224", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75183", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + lydicene", "d": [], "t": []}, {"i": "EC:4.2.3.210", "l": "\"lydicene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66422", "l": "ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + glutathione(in) + H2O + tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106009", "l": "(4S)-4-hydroxy-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176956", "l": "Formation of GINS complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68258", "l": "L-cystine(out) + Na(+)(out) => L-cystine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46756", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.42", "l": "\"palmitoyl-[glycerolipid] 7-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41098", "l": "H2O + sphing-4-enine-phosphocholine <=> H(+) + phosphocholine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044017", "l": "histone H3K27 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33463", "l": "episterol + H(+) + NADPH + O2 = 5-dehydroepisterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13183", "l": "ADP + H(+) + nitrate(in) + phosphate => ATP + H2O + nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31715", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602484", "l": "Activation of proMMP11 by FURIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250280", "l": "ROS oxidize thioredoxin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14515", "l": "ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate => ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28238", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12202", "l": "CO2 + mugineate + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16449", "l": "acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B", "d": [], "t": []}, {"i": "EC:2.3.1.82", "l": "\"aminoglycoside 6'-N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.26", "l": "\"peptide-tryptophan 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24160", "l": "D-galactose + O2 = D-galacto-hexodialdose + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.9", "l": "\"galactose oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41534", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2484822", "l": "Kinetochore assembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.93", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41577", "l": "dTDP-beta-L-mycarose + erythronolide B => 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19625", "l": "L-threonine = acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38225", "l": "1-O-decyl-(9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + decan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16844", "l": "precorrin-2 + S-adenosyl-L-methionine <=> H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357472", "l": "PAK1-3 autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14413", "l": "biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.39", "l": "\"biphenyl-2,3-diol 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64873", "l": "D-ribulose 1-phosphate => dihydroxyacetone phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14530", "l": "ADP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.60", "l": "\"caspase-7\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981926", "l": "RAC1 and CDC42 activate PAK3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446694", "l": "IRAK4 phosphorylates IRAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797090", "l": "CCNK binds CDK12 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37633", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179417", "l": "Multiubiquitination of Nek2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034875", "l": "caffeine oxidase activity", "d": ["Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46925", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA => 4-methylpent-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49342", "l": "2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30050", "l": "chloroacetaldehyde + H2O + NAD(+) <=> chloroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433488", "l": "Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.174417394798667", "identifiers": [{"i": "GO:0140906", "l": "halogenase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + oxygen donor = R-C-halogen +H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42440", "l": "L-aspartate + NAD(+) = H(+) + iminosuccinate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-879459", "l": "F-actin capping protein is a heterodimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102605", "l": "cyclooctat-9-en-5,7-diol C18-monooxygenase activity", "d": ["Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ = cyclooctatin + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296301", "l": "CCRL2 binds CCL19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27878", "l": "2',3'-cyclophospho-UMP + H2O = 3'-UMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.21", "l": "\"polo kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709547", "l": "ESTG binds ESR2:chaperone complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29507", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.72", "l": "\"alpha-gurjunene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008201", "l": "heparin binding", "d": ["Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69583", "l": "dGMP + inosine <=> 2'-deoxyguanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10205", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] => formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617828", "l": "TRIP11:IFT20 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17078", "l": "H2O + N,N-dimethylglycine + O2 => formaldehyde + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351948", "l": "Mitochondrial recruitment of Drp1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24172", "l": "A + a 3-oxo-5beta-steroid = a 3-oxo-Delta(4)-steroid + AH2", "d": [], "t": []}, {"i": "EC:1.3.99.6", "l": "\"3-oxo-5beta-steroid 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017174", "l": "glycine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14459", "l": "3-propylmalate + CoA + H(+) => glyoxylate + H2O + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19885", "l": "(S)-reticuline + O2 = (S)-scoulerine + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.21.3.3", "l": "\"reticuline oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53045", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34078", "l": "an acyl phosphate + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340214", "l": "CYGB binds O2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10052", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174494", "l": "Synthesis of ENV polyprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38344", "l": "(20S)-ginsenoside Rd + H2O => (20S)-ginsenoside Rg3 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718360", "l": "GNRHR binds GNRHR peptide agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69297", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51990", "l": "18S-resolvin E1 => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0020037", "l": "heme binding", "d": ["Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791235", "l": "GADD45A binds AURKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202174", "l": "Activation of ZAP-70 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156699", "l": "Inactivation of Wee1 kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047741", "l": "cetraxate benzylesterase activity", "d": ["Catalysis of the reaction: benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76067", "l": "an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine = an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15118", "l": "3'-dephospho-CoA + ATP => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11297", "l": "2,5-dioxopentanoate + H2O + NADP(+) => 2-oxoglutarate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60979", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63362", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19037", "l": "an epoxide + H2O = an ethanediol", "d": [], "t": []}, {"i": "EC:3.3.2.10", "l": "\"soluble epoxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050422", "l": "strictosidine beta-glucosidase activity", "d": ["Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59572", "l": "H2O + L-homocarnosine = 4-aminobutanoate + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42352", "l": "(R)-nicotine + A + H2O = (R)-6-hydroxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43381", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] => L-arginyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.113", "l": "\"deoxyguanosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72111", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) = L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22287", "l": "2 H(+) + H2O + N-carbamoylputrescine <=> CO2 + NH4(+) + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1810457", "l": "ZBP1(DAI) recruits RIP1 and RIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944522", "l": "miR-19a microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72245", "l": "guaiacol + H(+) + S-adenosyl-L-homocysteine => catechol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63112", "l": "A + ascofuranol = AH2 + ascofuranone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9660192", "l": "VDR agonists bind VDR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39462", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654399", "l": "Activated FGFR2 binds FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36454", "l": "ATP + glycyl-L-glutamate(out) + H2O <=> ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61151", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378952", "l": "Thyrotropin is a heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76626", "l": "(R)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51733", "l": "glandicoline B + S-adenosyl-L-methionine => H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66981", "l": "2-methylbutanoyl-CoA + H2O => 2-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48505", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69409", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) => androst-4-ene-3,11,17-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008054", "l": "IL1F10 binds IL1RAPL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785684", "l": "Fibronectin degradation by CTSG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24770", "l": "chlorophyllide b + H(+) + NADH => 7(1)-hydroxychlorophyllide a + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174551", "l": "Formation of alternative pathway C5 convertase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40905", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210430", "l": "Release of L-Glutamate at the synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23903", "l": "cis-stilbene oxide + H2O <=> (1R,2R)-hydrobenzoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33715", "l": "4-hydroxyeicosasphinganine 1-phosphate = 2-hydroxyoctadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43344", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) = [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.73", "l": "\"sulfur carrier protein ThiS adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58536", "l": "glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48462", "l": "2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55352", "l": "all-trans-retinol = 13-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062047", "l": "pipecolic acid N-hydroxylase", "d": ["Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507875", "l": "Aquaporins passively transport urea into cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944214", "l": "Association of procollagen type I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30320", "l": "H(+) + NADH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50211", "l": "cortisol + NAD(+) <=> cortisone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77261", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31974", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42565", "l": "uridine(38/39) in tRNA => pseudouridine(38/39) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30942", "l": "ATP + dIDP <=> ADP + dITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700137", "l": "ALK:MDK dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497855", "l": "Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983424", "l": "Budding of COPII coated vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0070456", "l": "galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2471842", "l": "Collagen type XXV ectomain shedding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865182", "l": "OTUD7A hydrolyses K11diUb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806974", "l": "MET dimers autophosphorylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52869", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28147", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] => 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113446", "l": "Initiation of RNA Polymerase III Productive Transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55467", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28882", "l": "H(+)(in) + L-tryptophan(in) <=> H(+)(out) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010303", "l": "limit dextrinase activity", "d": ["Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608825", "l": "DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.61", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42933", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061821", "l": "telomeric D-loop binding", "d": ["Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43842", "l": "(3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358790", "l": "RNF41 ubiquitinates ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42798", "l": "cholesteryl (9Z,12Z)-octadecadienoate + CoA => (9Z,12Z)-octadecadienoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43150", "l": "H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine => adenosine(9) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47843", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52071", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432164", "l": "Ca2+ influx into the post-synaptic cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17334", "l": "O-acetyl-L-serine + zeatin => acetate + H(+) + L-lupinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2399913", "l": "atRAL binds to RBP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12197", "l": "keto-D-fructose 6-phosphate + phosphate => acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163320", "l": "Association of mTERF with the termination sequence (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043994", "l": "histone H3K23 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.125", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72138", "l": "putrescine(out) <=> putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052897", "l": "N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59866", "l": "(indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65211", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O <=> (S)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21187", "l": "a dolichyl phosphate + GDP-alpha-D-mannose <=> a dolichyl beta-D-mannosyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247847", "l": "WLS is endocytosed to the early endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416929", "l": "PTGFR binds PGF2a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38362", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 <=> thiosulfate + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14195", "l": "2,3-dihydroxybenzoate + A + H2O => 3-hydroxybenzoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730903", "l": "Oligomerization of TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.1", "l": "\"Aspergillus nuclease S1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59825", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate => L-glutamate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130731", "l": "Formation of COPII vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62943", "l": "H2O + N(4)-acetylcytosine <=> acetate + cytosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050202", "l": "octopamine dehydratase activity", "d": ["Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62704", "l": "glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65979", "l": "7-dehydrocholesterol + hnu <=> previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39511", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA = (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41374", "l": "1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69305", "l": "(Z)-glucotropeolin + H2O => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29364", "l": "dCMP + H2O => 2'-deoxycytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34528", "l": "L-phenylalanine => (S)-3-amino-3-phenylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29094", "l": "a ubiquinone + 5 H(+)(in) + NADH <=> a ubiquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77750", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacylglycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49897", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047208", "l": "o-dihydroxycoumarin 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45280", "l": "12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46542", "l": "a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76612", "l": "H(+) + NADPH + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20487", "l": "(S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015398", "l": "high-affinity secondary active ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.63", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43406", "l": "H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP => N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237129", "l": "Acireductone is created (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50761", "l": "a quinone + H2O + sulfite => a quinol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48737", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871227", "l": "RET binds GFRA4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11800", "l": "H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71901", "l": "H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide => 3',5'-cyclic GMP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75882", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine <=> methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56147", "l": "a quinol + nitrate <=> a quinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693243", "l": "RHOD translocates to the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172666", "l": "RB1 binds condensin II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11342", "l": "4-guanidinobutanal + CO2 => 5-guanidino-2-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102405", "l": "(+)-taxifolin 5'-hydroxylase activity", "d": ["Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ = (+)-dihydromyricetin + NADP(3-) + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33152", "l": "(R)-dihydrolipoamide + acetyl-CoA => (R)-S(6)-acetyldihydrolipoamide + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23166", "l": "a flavonol 7-O-beta-D-glucoside + H(+) + UDP => a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874849", "l": "CREBRF binds CREB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.15", "l": "\"(methyl)glyoxal oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69569", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71405", "l": "2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990050", "l": "phosphatidic acid transfer activity", "d": ["Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141691", "l": "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38327", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30002", "l": "ATP + H2O + spermidine(out) <=> ADP + H(+) + phosphate + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635842", "l": "ULK3 phosphorylates GLI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:1903425", "l": "fluoride transmembrane transporter activity", "d": ["Enables the transfer of fluoride from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70071", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol = (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23351", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65661", "l": "A + calciol + H2O => AH2 + calcidiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16131", "l": "H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13616", "l": "beta-D-fructose 6-phosphate + diphosphate <=> beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66771", "l": "ATP + coproporphyrin I(in) + H2O <=> ADP + coproporphyrin I(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10073", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine => glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22787", "l": "(2R)-O-phospho-3-sulfolactate <=> H(+) + phosphoenolpyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796617", "l": "MIB2 binds CFLAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40184", "l": "O2 + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050326", "l": "taxifolin 8-monooxygenase activity", "d": ["Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19262", "l": "ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013435", "l": "RHOD auto-activates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29217", "l": "menaquinone-8 + succinate => fumarate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58763", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39458", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38487", "l": "1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60556", "l": "uridine(35) in tRNA(Tyr) = pseudouridine(35) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77059", "l": "3-methylcyclopentanamine + H2O + NADP(+) = 3-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75693", "l": "2'-deoxyadenosine(out) => 2'-deoxyadenosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72211", "l": "(+)-isoborneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782655", "l": "HDAC10 deacetylates histone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58913", "l": "ATP + H2O + iron(III) dicitrate(out) => ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74555", "l": "(S)-malate(out) = (S)-malate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66621", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709831", "l": "HSP90 binds TBK1 and IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54928", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16877", "l": "3-sulfino-L-alanine + H(+) = CO2 + hypotaurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28373", "l": "oxaloacetate + phosphate <=> hydrogencarbonate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41096", "l": "H2O + sphing-4-enine-phosphocholine => H(+) + phosphocholine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34904", "l": "4 glutathione + 2 H(+) + selenite => glutathione disulfide + 3 H2O + selenodiglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17412", "l": "(S)-coclaurine + S-adenosyl-L-methionine <=> (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221061", "l": "TDG excises 5-carboxylcytosine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48109", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61539", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62724", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide C + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69461", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine => [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951966", "l": "EP300 acetylates RUNX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68630", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47272", "l": "monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019010", "l": "farnesoic acid O-methyltransferase activity", "d": ["Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46440", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 = A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.14", "l": "\"linoleoyl-lipid Delta(9) conjugase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102753", "l": "chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate = geranylgeranyl-chlorophyll b + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27687", "l": "ATP + GDP => ADP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399711", "l": "Activation of Ca impermeable AMPA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61236", "l": "H2O + L-methionine + O2 = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202375", "l": "Recruitment of ITK to SLP-76 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389381", "l": "Gads binds CD28 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34389", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19921", "l": "D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43307", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer <=> 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708457", "l": "HM13 cleaves HMOX1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662908", "l": "Dopaquinone, cysteine form CD isomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33856", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44166", "l": "adenine + D-ribose 5-triphosphate => ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60046", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP => beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40993", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30639", "l": "(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.269", "l": "\"mannosylglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18787", "l": "AH2 + gibberellin A12 + H(+) => A + gibberellin A12 aldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454916", "l": "The ABCC family mediates organic anion transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.05410220942472", "identifiers": [{"i": "GO:0043167", "l": "ion binding", "d": ["Binding to an ion, a charged atoms or groups of atoms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36606", "l": "2-oxoglutarate + L-enduracididine + O2 <=> (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45778", "l": "(indol-3-yl)acetate + NH4(+) => (indol-3-yl)acetonitrile + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33804", "l": "H2O + L-histidinal + NAD(+) => 2 H(+) + L-histidine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685605", "l": "SLAMF7 binds SLAMF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990313", "l": "type-III cohesin domain binding", "d": ["Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12637", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.50", "l": "\"procollagen galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419011", "l": "Transhomodimerization of Nectins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17631", "l": "alpha,alpha-trehalose(out) => alpha,alpha-trehalose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56164", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35799", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624949", "l": "Assembly of the anterograde IFT train (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604954", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655843", "l": "Expression of Fatty Acid Synthase (FASN) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39475", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA = (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480378", "l": "Expression of Goosecoid (GSC) in the primitive streak (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47566", "l": "a ganglioside GA2 (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73099", "l": "3'-dephospho-CoA(in) + AMP(out) = 3'-dephospho-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30012", "l": "ATP + beta-D-galactose(out) + H2O => ADP + beta-D-galactose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708457", "l": "HM13 cleaves HMOX1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23485", "l": "A + D-cellobiose => AH2 + D-cellobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43288", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69101", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17303", "l": "ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204824", "l": "Interaction of Tie2 and Ang4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59449", "l": "dodecan-1-ol + NADP(+) => dodecanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11098", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53687", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446372", "l": "Association of  PARVA with TESK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26020", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O => beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17574", "l": "demethylmacrocin + S-adenosyl-L-methionine => H(+) + macrocin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10630", "l": "a ribonucleoside 5'-diphosphate + tRNA(n) => phosphate + tRNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139919", "l": "Translocation of BIM to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67183", "l": "ATP + glycine + L-glutamyl-[protein] <=> ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010327", "l": "acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76340", "l": "2 Na(+)(out) + urate(out) => 2 Na(+)(in) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660660", "l": "p300 acetylates RELA subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072585", "l": "xanthosine nucleotidase activity", "d": ["Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102472", "l": "eriodictyol 2-hydroxylase activity", "d": ["Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ = 2-hydroxyeriodictyol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8960973", "l": "RLBP1:11cRAL dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25987", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24018", "l": "CoA + vinorine => 16-epivellosimine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28652", "l": "inosine + O2 => 9-riburonosylhypoxanthine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229118", "l": "Defective SLC37A4 does not exchange G6P and Pi across the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729454", "l": "SARS-CoV-2 N protein binds STAT1, STAT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60304", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59974", "l": "CoA + O-decanoyl-L-seryl-[protein] => decanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11550", "l": "5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32695", "l": "(2E)-geranyl diphosphate = (-)-car-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30054", "l": "fluoroacetate + H2O <=> fluoride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54781", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165034", "l": "Rev multimer-bound  HIV mRNA:CRM1 complex associates with Ran:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163310", "l": "TFAM binds to mitochondrial promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004817", "l": "cysteine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44505", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate => a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627056", "l": "Procaspase 9 forms dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69068", "l": "RFC dissociates after sliding clamp formation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58604", "l": "FAD + 2 H(+) + NADH + O2 = FADH2-C4alpha-hydroperoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67040", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) = asnovolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177284", "l": "PKA phosphorylates PDE4B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36521", "l": "3-oxooctacosanyol-CoA + CO2 + CoA => H(+) + hexacosanoyl-CoA + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749609", "l": "BCHE hydrolyzes ASA- (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446322", "l": "PARVA associates with Paxillin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59191", "l": "L-histidine <=> D-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23471", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 <=> 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55528", "l": "H(+) + H2O + L-tyrosine + O2 = (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:4.1.1.108", "l": "\"4-hydroxyphenylacetaldehyde synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48761", "l": "L-threitol + NAD(+) => H(+) + L-erythrulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22484", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.17", "l": "\"bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804253", "l": "MDM2 ubiquitinates JMY (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684241", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68016", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)-geranylgeraniol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473596", "l": "Collagen type I degradation by MMP15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34562", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) <=> 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65125", "l": "benzoyl-CoA + ethanol => benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102287", "l": "4-coumaroylhexanoylmethane synthase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O = 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336184", "l": "GPR37L binds prosaposin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018798", "l": "RHOV binds GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47275", "l": "monoanhydrobacterioruberin <=> bisanhydrobacterioruberin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20775", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) <=> 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17231", "l": "an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12700", "l": "ATP + dGMP <=> ADP + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43144", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.217", "l": "\"tRNA (adenine(22)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017188", "l": "aspartate N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656891", "l": "OPN1SW binds 11cRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21897", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018516", "l": "2,4-dichlorobenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP+ = 2,4-dichlorobenzoyl-CoA + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54564", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.7.79", "l": "\"tRNA(His) guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75782", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O <=> (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112437", "l": "Formation of NELF complex  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36812", "l": "acetyl-CoA + GDP-alpha-D-perosamine => CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102657", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55504", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] = (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.72", "l": "\"drimenol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17239", "l": "diphosphate + FAD => ATP + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56188", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37862", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA <=> 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37418", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047038", "l": "D-arabinitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-arabinitol + NAD+ = D-ribulose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444433", "l": "Cho transports from the extracellular space to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32460", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71817", "l": "3,3',5'-triiodo-L-thyronine(in) => 3,3',5'-triiodo-L-thyronine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046409", "l": "p-coumarate 3-hydroxylase activity", "d": ["Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73550", "l": "GTP(out) + UTP(in) <=> GTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62525", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46248", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45819", "l": "(S)-lactate + A <=> AH2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59588", "l": "ATP + beta-alanine + L-ornithine = ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76159", "l": "fluoride(in) = fluoride(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1250264", "l": "TXNIP binds reduced thioredoxin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48250", "l": "CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16375", "l": "(R)-4'-phosphopantothenate + ADP + H(+) => (R)-pantothenate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76552", "l": "acetyl-CoA + D-aspartate => CoA + H(+) + N-acetyl-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43456", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296045", "l": "Activation of Potassium transport channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20219", "l": "dimethylamine + formaldehyde => H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60269", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13224", "l": "(R)-mevalonate + NAD(+) <=> (R)-mevaldate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59749", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814387", "l": "CASP14 cleaves filaggrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429767", "l": "Passive I- efflux mediated by SMCT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55034", "l": "an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N-methylornithine lipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70115", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62971", "l": "(R)-lactate + NADP(+) <=> H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691004", "l": "XPC binds RAD23 and CETN2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034530", "l": "4-hydroxymethylsalicyaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32642", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73152", "l": "CoA(out) + FMN(in) => CoA(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63786", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102821", "l": "bixin methyltransferase activity", "d": ["Catalysis of the reaction: bixin + S-adenosyl-L-methionine = bixin dimethyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11271", "l": "D-cysteine + H2O <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46996", "l": "6-hydroxy-N-methylmyosmine + H2O = 6-hydroxypseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60660", "l": "1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236970", "l": "Proteasomal clevage of exogenous antigen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26078", "l": "methanesulfonate + NADH + O2 => formaldehyde + H2O + NAD(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205321", "l": "Interaction of KIT and sSCF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050529", "l": "polyneuridine-aldehyde esterase activity", "d": ["Catalysis of the reaction: H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67929", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O => a 3'-end 3'-phosphouridine-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64908", "l": "CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50612", "l": "decanal + NADP(+) = (2E)-decenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629358", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007707", "l": "DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14290", "l": "a dicarboxylate + ATP + CoA => AMP + diphosphate + omega-dicarboxyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874080", "l": "SRC phosphorylates PTK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58278", "l": "cyclic hexaadenylate + 6 diphosphate => 6 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035180", "l": "Expression of EEPD1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10125", "l": "H(+) + NADPH + O2 + phenylacetone => benzyl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50724", "l": "(E)-4-hydroxyphenylacetaldehyde oxime = (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52090", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.-", "l": "\"Other carbon-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420202", "l": "Secretin receptor binds secretin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102200", "l": "N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity", "d": ["Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140566", "l": "histone reader activity", "d": ["A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428260", "l": "DEGS2 oxygenates dihydroceramide (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655170", "l": "RCHY1 monoubiquitinates POLH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46665", "l": "corticosterone + H(+) + NADPH => 5beta-dihydrocorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034938", "l": "pyrrole-2-carboxylate monooxygenase activity", "d": ["Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13899", "l": "prephenate => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14175", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71480", "l": "H2O + neurotensin => L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603534", "l": "Unknown caspase cleaves NTRK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928625", "l": "PAKs autophosphorylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038047", "l": "morphine receptor activity", "d": ["Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019799", "l": "tubulin N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75859", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6802973", "l": "PLK3 phosphorylates CDC25C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31076", "l": "(3S)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54198", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19445", "l": "2,3-dihydroxyindole + O2 = anthranilate + CO2 + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.23", "l": "\"2,3-dihydroxyindole 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686430", "l": "MUS81 binds EME1, EME2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27504", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine <=> 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75848", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46789", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34215", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) = 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.83", "l": "\"3-succinoylsemialdehyde-pyridine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030625", "l": "U11 snRNA binding", "d": ["Binding to a U11 small nuclear RNA (U11 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.-", "l": "\"In other compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.425240171993906", "identifiers": [{"i": "GO:0004566", "l": "beta-glucuronidase activity", "d": ["Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71937", "l": "glycocholate(in) + 2 Na(+)(in) => glycocholate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39213", "l": "(2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57535", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) <=> a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.749177222804775", "identifiers": [{"i": "GO:0071723", "l": "lipopeptide binding", "d": ["Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68711", "l": "(2E)-geranyl diphosphate + H2O <=> diphosphate + linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11859", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226979", "l": "ADD1:ADD2 binds DMTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59545", "l": "N,N'-diacetylchitobiose + O2 => H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46937", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) => ATP + H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624120", "l": "CEBPA binds CDK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840488", "l": "PSAP(195-273) forms a dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25640", "l": "H2O + NAD(+) + sulfoacetaldehyde <=> 2 H(+) + NADH + sulfoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53729", "l": "H2O + N-acetyl-D-muramate 6-phosphate => N-acetyl-D-muramate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33377", "l": "a 1-acyl-sn-glycero-3-phosphate + NADP(+) => a 1-acylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047539", "l": "2-deoxyglucosidase activity", "d": ["Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59982", "l": "8-oxo-dGDP + H(+) + phosphate => 8-oxo-dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607002", "l": "Activated protein C cleaves factor VIIIa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16782", "l": "a fatty acyl-CoA + H2O => a fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.27", "l": "\"RING-type E3 ubiquitin transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25602", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O => 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41351", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72672", "l": "The 60S subunit joins the translation initiation complex  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562541", "l": "TLR4-induced ripoptosome assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34797", "l": "alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70647", "l": "D-serine(out) + H(+)(out) = D-serine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62604", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11447", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45319", "l": "H(+) + NADPH + prostaglandin D2 <=> 11beta-prostaglandin F2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.802976799984464", "identifiers": [{"i": "GO:0015373", "l": "monoatomic anion:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381087", "l": "Dimerization of PERK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034578", "l": "limonene 8-hydratase activity", "d": ["Catalysis of the reaction: limonene + H2O = alpha-terpineol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5252001", "l": "ATP1B4 binds SNW1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21291", "l": "D-glucose + sn-glycerol 3-phosphate <=> D-glucose 6-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161293", "l": "Tropoelastin forms aggregate globules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57197", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glycolate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990738", "l": "pseudouridine 5'-phosphatase activity", "d": ["Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705926", "l": "AR binds AR agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948757", "l": "AKT phosphorylates MKRN1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977238", "l": "Activated TLR5/TLR15 homodimer recruits MyD88 adaptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688397", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67310", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374337", "l": "Apelin receptor binds to apelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209840", "l": "Two DITs combine to form thyroxine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421179", "l": "inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56652", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.70", "l": "\"glucan 1,6-alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48260", "l": "a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682010", "l": "ATG10:ATG12 binds ATG5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.850480343987797", "identifiers": [{"i": "GO:0005371", "l": "tricarboxylate secondary active transmembrane transporter activity", "d": ["Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50458", "l": "prostaglandin D3 => prostaglandin H3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49927", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11487", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) <=> a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63034", "l": "a fatty acid + NH4(+) => a fatty acylamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22712", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.62", "l": "\"adenosylcobinamide-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247847", "l": "WLS is endocytosed to the early endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72598", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) <=> H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28256", "l": "(3Z)-hex-3-en-1-yl acetate + CoA => (3Z)-hex-3-en-1-ol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19627", "l": "acetaldehyde + glycine => L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75635", "l": "(9Z)-octadecenoate + O2 = 10-hydroperoxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.116", "l": "\"glucan 1,4-alpha-maltotriohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40607", "l": "1-tetradecanoyl-sn-glycerol + H2O = glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57089", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396029", "l": "Latent TGF-beta-3 binds integrins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11107", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + hercynine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20305", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.64", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835328", "l": "NPM binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810376", "l": "ING2 binds PI5P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028598", "l": "Phosphorylation of YAP by LATS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990162", "l": "histone H3K4 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74961", "l": "(3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate => (3R)-3-isocyanylbutanoate + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705299", "l": "SARS-CoV-2 6 binds KPNA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32151", "l": "9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.99", "l": "\"labdatriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24187", "l": "4,5-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200646", "l": "Cytosolic folate export across the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11489", "l": "all-trans-retinol + an acyl-CoA => an all-trans-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626817", "l": "PKC phosphorylates NCF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024906", "l": "BDNF binds NTRK2 (TRKB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790454", "l": "SUMOylation of XPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27341", "l": "AH2 + NH4(+) + O2 = A + H(+) + H2O + hydroxylamine", "d": [], "t": []}, {"i": "EC:1.14.99.39", "l": "\"ammonia monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112429", "l": "Formation of FACT complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196929", "l": "FLAD1 phosphorylates FMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64897", "l": "2 H2O + UTP => 2 H(+) + 2 phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31373", "l": "(2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine => (2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21017", "l": "H2O + L-asparagine => L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.157", "d": [], "t": []}], "taxa": []}
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